association	dataset	threshold value	standardized value
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.981252
Prostate adenocarcinoma_PRAD_TCGA-CH-5745-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.128689
hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.269521
JDP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103636
innate immune response	GO Biological Process Annotations 2015	1.0	null
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38043
cancer	GAD High Level Gene-Disease Associations	1.0	0.295739
CRCGN017_MCF10A.TP53.M_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20279
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
GNA12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00886319
BRD-K15522385_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	2.85692
Birth Weight	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K87808996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16969
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAMTOR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523265
CRCGN012_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18831
golgi lumen	GO Cellular Component Annotations 2015	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.473936
GRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072765
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K07667918_linsitinib_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neutrophil degranulation	Reactome Pathways 2024	1.0	null
TSPAN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00939358
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glomerulonephritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
BRD-K92569554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35092
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051776
C8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00760354
BRD-A38030642_cyclosporin A_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72145393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23006
polycythemia vera	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.474877
BRD-A52530684_DOXORUBICIN_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SH3BP5L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490003
BRD-K30707190_PNU 74654_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K01877528_TL_HRAS26_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68185022_Ursolic Acid_MCF7_24.0_h_70.07_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.899
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.37
BRD-K03736784_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67658
BRD-K61370861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88895
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71563
VSIG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471702
CTCF-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
azurophil granule	GO Cellular Component Annotations 2025	1.0	null
MZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29793
BRD-K36583698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11328
PKDCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055571
GLO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00719997
BRD-K41859756_-666_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83848
Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T cell chemotaxis	GO Biological Process Annotations 2025	1.0	null
HPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00751574
CCDC122	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00853466
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.18414
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16228393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07572
SPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00373335
protein homodimerization activity	GO Molecular Function Annotations 2023	1.0	null
HCST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530403
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22873
BRD-A01717111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08141
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A60245366_AS-601245_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6286
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4559
BRD-K42191735_buparlisib_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
specific granule	GO Cellular Component Annotations 2023	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7086
PMC4858740-ncomms11473-s2.xls-HAdV-D9_cr1b_Library_1-Hit_name_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
HT29	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69969
GSE162575,GSE162609_5_v_4_tfe3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31647
Sarcoma_SARC_TCGA-DX-A3U6-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43389698_BMS-387032_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRKACG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065171
flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.132137
NAT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637156
Posterior adductor muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
DMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00917877
BRD-K08845546_FK506_NCIH1694_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACAD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566572
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49204
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.813144
BRD-K99749624_S1003_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00429942
BRD-K52075040_-666_PL21_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37392901_NSC 632839 hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055121
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.1641
Secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.809
BRD-A45333398_PERIPLOCYMARIN_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K15935639_Z-Leu3-VS_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K80575072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24021
HIST1H2AB	Pathway Commons Protein-Protein Interactions	1.0	null
CKMT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044001
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8682
BRD-K54233340_Dorsomorphin dihydrochloride_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7441
MAMSTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580706
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24511
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.076202
CHEK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618453
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.966413
CLEC12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00707393
COG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0114575
FGF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514379
TNFRSF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058963
nape	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.934054
PLCXD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0099037
APUD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.128
BRD-A84695402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2987
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16659
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.420641
GPR82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744235
PRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00774733
BRD-K13390322_AT-7519_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AMY1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648664
killing of cells of other organism	GO Biological Process Annotations 2015	1.0	null
Thrombosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
Lung squamous cell carcinoma_LUSC_TCGA-22-4609-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTNS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645817
s100a7	GeneRIF Biological Term Annotations	1.0	null
DEF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00744803
BRD-K49371609_528116.cdx_PC3_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922292
pheniramine-1492	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL18R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104047
BRD-A45349889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24904
PLCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00889824
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.808
BRD-K69852452_F1566-0341_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88573743_A443654_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065488
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
schizoaffective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.823308
BRD-K12884811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60528
BRD-A34806832_Proscillaridin A_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82145108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07878
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36938
BRD-A13122391_16-HYDROXYTRIPTOLIDE_A375_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16061
SCC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42787
HC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83324
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2426
BRD-K81418486_vorinostat_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.434882
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.966413
JVM3	DepMap CRISPR Gene Dependency	1.0	9.31268
IGHG1	Pathway Commons Protein-Protein Interactions	1.0	null
Spleen-intermediate monocyte	Tabula Sapiens Gene-Cell Associations	1.0	0.663011
CLEC10A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705517
BRD-K33379087_tivantinib_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27721098_clopidogrel_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.958681
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KU812	CCLE Cell Line Gene CNV Profiles	1.0	1.35615
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A1-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC812	CCLE Cell Line Gene Expression Profiles	-1.0	-2.34363
BRD-K96596828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16959
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUCKS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00394605
OVOL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00872456
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A20697603_T8902_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68548958_-666_SNGM_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COL7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00688455
chlorpromazine-5577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.838902
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.066342
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84583
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.57469
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
CLOCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054081
HIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00956551
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02786
BRD-K79065821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1683
BRD-K80622725_STK397047_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	7.01029
NPTX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0124014
BRD-A73909368_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LSM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00472624
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE196117_1_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0806
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29368
TKFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693243
PHTF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500139
ZNF831	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533288
KCNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504236
BRD-K02602127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.578
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849017
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53904
LGR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050216
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.20229
modification of morphology or physiology of other organism	GO Biological Process Annotations 2015	1.0	null
BRD-A55756846_EI-148_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EVI2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00902143
BRD-K49328571_dasatinib_MCF10A_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07185
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26643
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16554464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13628
CTSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00322654
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92311828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31898
CXCL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00706978
ABCD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00905204
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26084
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67352070_TC 2559 difumarate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5603
Transcriptional misregulation in cancer	KEGG Pathways 2026	1.0	null
BRD-K43389698_BMS-387032_LNCAP_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRIN2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586826
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-M64432851_S1042_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92778217_MEFENAMIC ACID_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IGHA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42361742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10895
bone marrow	HPA Tissue Protein Expression Profiles	1.0	1.89358
SPATA2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566937
BRD-K09416995_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NAE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00419376
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5161
Enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
GLRX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00280846
Extracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.777
BRD-K14888893_minoxidil_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IFI44L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542719
BRD-A28105619_curcubitacin I_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6561
BRD-K45894579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12907
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052062
GGT7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688536
BRD-K03816923_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
ventral anterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.850364
CHRNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752275
CUX1	ChEA Transcription Factor Targets	1.0	null
GSE234155_7_v_1_nfix_human	RummaGEO Gene Perturbation Signatures	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2593
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50165
COLO680N	CCLE Cell Line Gene Expression Profiles	-1.0	-2.15743
MTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536282
BRD-K68202742_trichostatin A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13390322_AT-7519_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00373568
Acute dacryocystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
BRD-K92571446_WZ-3105_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51575138_TPCA-1_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K01877528_TL_HRAS26_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45190659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09812
CPNE3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00376462
BRD-A20697603_T8902_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67844266_MLN4924_SW948_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disruption of plasma membrane integrity in another organism	GO Biological Process Annotations 2025	1.0	null
PPP6R3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00766467
NCIH2126	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80733
SF3A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00931565
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59783
REL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692977
LY9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006121
ketorolac-6489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4261
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
BRD-K02822062_CT-200783_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DYNC1LI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8316
extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
mucosal immune response	GO Biological Process Annotations 2023	1.0	null
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
resveratrol-2865	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63426
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5162-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pheniramine-4130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TP53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00804463
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051387
BRD-K37720887_SB-525334_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K23984367_sorafenib_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dropropizine-2398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-298	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K43389698_BMS-387032_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZG16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837766
RGL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493321
LGALS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474271
VPS35	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624507
BRD-K69387464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42876
DLG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00360276
BRD-K88677950_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5378
nuchal ligament	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.14033
BRD-K43389698_BMS-387032_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1112
BRD-K86574132_-666_HT115_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K25737009_-666_VCAP_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
GRIA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076239
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1039
PLD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540831
BRD-K04623885_BIBR1532_PL21_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21752
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5388
NHP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606165
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.988044
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A1A1-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.694946
POLR2A	ENCODE Transcription Factor Targets	1.0	null
FXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00363297
BRD-K12181036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11516
15902281-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
BRD-A85860691_chaetocin_HT29_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76543697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38232
BRD-K49328571_dasatinib_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-NR4A1_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
TIPIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0071715
GNG11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649449
u	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
MAST4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.015244
Vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
FGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00758687
Monocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2301
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00881525
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964019
BRD-K94012289_OSI-027_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
specific granule	GO Cellular Component Annotations 2025	1.0	null
PPP6C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00782882
BRD-K88625236_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638098
BRD-U64289953_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84595254_Strophanthidin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A85860691_chaetocin_WSUDLCL2_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K66870022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64662
BRD-A44008656_DOXYLAMINE SUCCINATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K02130563_S1030_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
metoclopramide-3728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	2.33155
Mucous cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.326
BRD-K07762753_Aminopurvalanol A_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dexamethasone-2242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26065
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6665
BATF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639343
BRD-K34069025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95808
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05744
PLA2G6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00788487
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CEP170	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00874426
BRD-K71799778_BML-259_HEPG2_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NKX2-6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534757
RNF144B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00409585
BRD-K72451865_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49865102_PD-0325901_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56343971_vemurafenib_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-M34385771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00061
HM13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535082
Pseudomonas Infection_Lung Tissue_GSE923	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.30315
famprofazone-2174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13566078_HY-10518_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22087390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54665
SERPINA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00780918
Blood-cd24 neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	-0.199739
cellular response to molecule of bacterial origin	GO Biological Process Annotations 2025	1.0	null
BRD-K04923131_3194_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.547
cellular response to lipid	GO Biological Process Annotations 2025	1.0	null
CARD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00732056
phenelzine-2319	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NTRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612289
GFER	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538793
BRD-K60623809_SU11652_H1299_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-556-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K08409548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02466
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K49865102_PD-0325901_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K32362211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59338
BRD-K72216066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24034
specific granule lumen	GO Cellular Component Annotations 2025	1.0	null
terazosin-6092	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
THNSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00813798
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4467
BRD-A00881124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.83424
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56254
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6907-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8797
BRD-K83670234_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4311
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59782
BRD-K13390322_AT-7519_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07437885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00488
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.880812
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MTHFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652529
BRD-K49371609_528116.cdx_HCC15_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.84241
IGF2BP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646279
defa4	GeneRIF Biological Term Annotations	1.0	null
SNU213	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63422
MIR122_OE_GDS3470_573_human_Embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Immune System	Reactome Pathways 2024	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	1.0	1.01502
Cystic Fibrosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19949
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
defense response to other organism	GO Biological Process Annotations 2015	1.0	null
MAST3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807198
PMC11309649-medi-103-e37185-s002.xlsx-Sheet1-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A20697603_598226_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATP8B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508092
LYST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569977
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0051
Dermatitis, Atopic	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K68202742_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
NFS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00373783
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98072
BRD-K06666320_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ENTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517977
KY821	GDSC Cell Line Gene Expression Profiles	1.0	2.56585
BRD-K72238567_656402-250MG_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61033
BRD-K48029790_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2994
KMS34	DepMap CRISPR Gene Dependency	1.0	7.12282
BRD-K15025317_Bay 11-7821_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64782
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.758226
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0702
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PDE8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623718
STK33_SKM	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02985
epidermal	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A16332958_Modafinil_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.422292
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08335
neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.979783
molindone-4784	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OSCAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697956
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-intersection_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79768278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92483
CNGA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104623
COBLL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00891666
DPP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577098
Monocyte percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.63979
CIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801684
ENPP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625971
BRD-K90519599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86176
PGRMC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00286654
BRD-A30437061_Camptothecin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76723084_isotretinoin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
response to external biotic stimulus	GO Biological Process Annotations 2015	1.0	null
DVL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583176
FCGR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617159
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836218
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934213
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5833
BRD-K52522949_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2015	1.0	null
NCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00438337
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
GDM1	CCLE Cell Line Gene CNV Profiles	1.0	1.46631
Dendrite membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539708
BRD-K63068307_ZSTK-474_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SPC25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616057
PMS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049591
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37072
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27522
BRD-K99545815_HY-10459_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD160	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00730659
hsa-miR-651	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02758
KLRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704372
BRD-A34806832_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00460116
MEG01	CCLE Cell Line Gene Expression Profiles	1.0	1.63187
MKN7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33712
prilocaine-2314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K76534306_ENROFLOXACIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1766
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2498
UNC119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00912641
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09358
SNU620	CCLE Cell Line Gene CNV Profiles	1.0	1.39088
PSS008	DepMap CRISPR Gene Dependency	1.0	4.4162
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7828
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K78659596_MLN2238_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07292
BRD-K96084870_DMBI_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cytoplasmic vesicle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CELSR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710226
BRD-K15834839_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11297155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36525
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3632
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82864
BEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85483
BRD-K02822062_CT-200783_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Leukemia, Myeloid, Acute	HuGE Navigator Gene-Phenotype Associations	1.0	null
Small intestine cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
IRAK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702357
ileum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.335968
leukaemia	GeneRIF Biological Term Annotations	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918384
cervical epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565232
HTR5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0087531
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05581
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.072551
IHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652136
BRD-K52924481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24594
ADCY3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00956393
S1PR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103964
BRD-K15087476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09478
Specific granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.873
RFK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00755488
BRD-K49371609_528116.cdx_COV644_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCL2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00461961
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
PMC10318747-12864_2023_9472_MOESM2_ESM.xlsx-OCI-AML3_30min_vs_Control-Unnamed_1_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
HIVEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00761457
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anchored component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	0.947445
SW1116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46151
CRCGN014_HEPG2_3H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1803
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet3-SJIA_KD_RNAseq_array_overlap_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.973159
RTP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493813
BRD-K05236810_Luteolin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46424862_Hymecromone_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69840642_HDAC6 inhibitor ISOX_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TSLP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0111146
BRD-K93747373_HG-5-113-01_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06666320_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A52886023_A8674_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68257399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0066
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43396
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09375
PPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00389571
BRD-K71944493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55035
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.15314
Lung adenocarcinoma_LUAD_TCGA-91-6830-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051259
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4474
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2062
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00296
PMC3382229__F4	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K85493820_KM 00927_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DGKE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00965487
PRR14L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665601
BRD-K81608755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28359
BRD-K25504083_C8273_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5069771__F2	PFOCR Pathway Figure Associations 2024	1.0	null
significant	GeneRIF Biological Term Annotations	1.0	null
ENPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100213
SUPT7L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00803422
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702927
BRD-K10207760_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.3665
BRD-K15935639_Z-Leu3-VS_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86858124_Paclitaxel_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045681
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.230801
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
BRD-K68202742_trichostatin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectum adenocarcinoma_READ_TCGA-AH-6547-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BTNL10P	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615546
GATA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582316
Periodontal ligament cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
CYP2C19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066295
BRD-K36740062_HY-70044_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYD88	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655775
KRR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558553
LTF	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12087065-12887_2025_5752_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_The_COVID-19-related_KD_hub_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HL60	CCLE Cell Line Gene Expression Profiles	1.0	3.03862
HT1080	CCLE Cell Line Gene Expression Profiles	1.0	1.39705
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.255241
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855673
FCER1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554876
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.795701
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19220233_JNK-9L_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD180	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655762
BRD-A79768653_sirolimus_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PSG6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647352
CCL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620274
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.72733
BRD-K73200916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3852
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet4-array_SJIA_KD_up_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.349
GSU	CCLE Cell Line Gene CNV Profiles	1.0	1.45662
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04527
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.115
BRD-K64800655_HY-11001_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DCST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00801286
BRD-K18208847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18695
HIST1H2BL	Pathway Commons Protein-Protein Interactions	1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.8525
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59978
GBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560993
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
EZH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536917
myeloid	GeneRIF Biological Term Annotations	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.696172
BRD-K99749624_S1003_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LY75	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569922
BRD-K91271834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0603
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.901787
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.202009
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
BRD-K01182779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29578
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72071
SLC30A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105777
OR5F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106144
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01436366_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MGP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106442
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
NOMO-1	GDSC Cell Line Gene Expression Profiles	1.0	2.25932
GRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781861
mexiletine-2324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00870539
Alpha-defensins	Reactome Pathways 2024	1.0	null
BRD-K54997624_BYL719_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A28105619_curcubitacin I_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K18812295_Chrysene-1,4-quinone_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JK-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96254487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04355
BRD-K34092021_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12198
BRD-K68548958_-666_SW948_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARFGEF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00821269
LHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00928615
BRD-K29441085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07104
BRD-K13390322_AT-7519_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRDM14-20953172-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K50387473_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67462
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12847
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-11A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02072
APOBEC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00824888
DAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558884
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1588
LHCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709827
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AU-01A-32R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13566078_BMS-345541_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40621224_Pentetic acid_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532225
P2RY13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633792
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05625
tropicamide-3619	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prednisolone_homo sapiens_gpl570_gse32962	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.417718
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8883
SW480	CCLE Cell Line Gene Expression Profiles	1.0	1.79965
BRD-K43186783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07026
BRD-K79090631_CGP-60474_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ANKRD22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658725
NMRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770809
HIST1H2BH	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88418404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.86343
BRD-K14812927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06178
CRCGN014_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0062
FLT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044489
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Corticosterone	HMDB Metabolites of Enzymes	1.0	null
BRD-K82091397_HY-11068_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0117248
FZD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741664
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31647
BRD-K20278539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60125
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K54362440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05678
ADAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00907299
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99749624_S1003_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HIST1H2BK	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS571T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9959
HNRNPAB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666535
BRD-K65182930_NVP-AUY922_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37147
BRD-K24132293_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86171
Severe congenital neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
THERAPEUTIC CYTOKINE	DGIdb Drug Targets 2026	1.0	4.07169
saquinavir-3549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HLA-DPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0071865
BRD-K88710727_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CAL78	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99426
nitrofurantoin-2303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K39224209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30062
NCI-H187	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K99545815_PF-562271_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DMPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104941
Kidney disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
PDLIM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00784283
TTI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100943
PYGM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0105911
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.042769
BRD-K79321447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28775
BRD-K70057550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69298
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964019
decrease	GeneRIF Biological Term Annotations	1.0	null
GPM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571875
BRD-K06765193_5663823_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nimodipine-6480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A55594068_VINBLASTINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051555
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4442
BRD-K68548958_-666_MDST8_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A25736793_everolimus_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ETV7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00863834
crystal	GeneRIF Biological Term Annotations	1.0	null
BRD-K53959060_Indirubin-3-oxime_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CPOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573263
BRD-K48912618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21232
BRD-K57080016_selumetinib_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75252192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88483
18338247-SuppTable4B	GeneSigDB Published Gene Signatures	1.0	null
hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061924
BRD-K87909389_S1230_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A23290232_westcort_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13551
GK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00448073
TNFRSF10C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0081733
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1498
IL36G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522897
MMUT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519546
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7265
SLC25A22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575419
BRD-K72774661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32018
hsa-miR-3137	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17377
Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654825
BRD-K39987650_BISACODYL_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NECTIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697387
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3622
KYO1	DepMap CRISPR Gene Dependency	1.0	5.58393
HIV Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
Basophil count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.0699
TMEM158	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595398
Autoimmune disease of gastrointestinal tract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K07755570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22463
biological_process	GO Biological Process Annotations 2015	1.0	null
BRD-A02333338_C3393M50_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82899
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42453497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08932
cobalt chloride-383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51559
PIKFYVE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684925
BRD-U82589721_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04736
BRD-K83270526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40805
ARHGAP31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499029
SMS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.011935
BRD-A34806832_Proscillaridin A_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K66413698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.66663
BRD-A36318220_Necrostatin-1_U937_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K76861469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20408
Cough variant asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
VNN3P	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00847611
BRD-K70685307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28569
KCNN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593433
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.208
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CSDC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516003
BRD-K86268010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31575
iohexol-2461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06543683_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.34205
BRD-K39987650_BISACODYL_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
BRD-K54233340_Dorsomorphin dihydrochloride_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30277
ARIH2OS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0098812
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.899
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
BRD-K87230984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09803
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
innate immune response in mucosa	GO Biological Process Annotations 2025	1.0	null
GABRA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0084054
BRD-K06765193_5663823_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76723780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04822
CDC42	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526485
MEST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00411335
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845561
COLO783	CCLE Cell Line Gene CNV Profiles	1.0	2.12117
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2737
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27454
lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094619
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TEX101	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065144
BRD-A43155244_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Meningococcal Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K21680192_mitoxantrone_MCF10A_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
Polymorphonuclear neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
BRD-K37906141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01753
BRD-K77554836_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K00824317_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDC25B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583527
ornidazole-2272	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54660148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31737
defense response to bacterium	GO Biological Process Annotations 2015	1.0	null
tiaprofenic acid-2492	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4509
BRD-K42191735_buparlisib_BT20_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EFNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645687
CD151	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536232
MAPK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00360945
PCGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00767278
MLKL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576707
GLYATL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740847
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R7-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF3C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502433
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
BRD-K94247332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64911
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7479
defense response to symbiont	GO Biological Process Annotations 2025	1.0	null
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53902
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18914
BRD-K43978949_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A16478930_amcinonide_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K48735772_PD 158780_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K29415052_NVP-BGT226_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42436189_AZ20_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PTGDR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063942
BRD-K94452277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51386
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.80361
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39621
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3621
IL1RAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00803665
20460173-ImmPortAntimicrobials	GeneSigDB Published Gene Signatures	1.0	null
KP-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71173
GSTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00760569
integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042703
BRD-U51024685_HG-6-64-01_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPP2R2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00862768
MIF_DEPLETION_GDS3626_95_human_HEK293 kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K67458784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26001
Interstitial lung disease 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
CRCGN015_MCF10A.TP53.M_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3946
MMP27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617756
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76938712_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K76534306_ENROFLOXACIN_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434906
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21245
inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122562
Systemic lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04546108_JAK3 Inhibitor VI_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A49680073_Cucurbitacin I_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TGM2_KD_GSE23702_713_human_NB4 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
mRNA_SALL4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5041
MAGI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603045
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04988
TPBGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592697
BRD-K87316858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03257
response to bacterium	GO Biological Process Annotations 2015	1.0	null
BRD-A77216878_manumycin A_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAVER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063728
sulfadimethoxine-3702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12019
BRD-U60236422_WH-4-025_BT20_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
response to fungus	GO Biological Process Annotations 2015	1.0	null
Innate Immune System	Reactome Pathways 2014	1.0	null
BRD-K85972696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43368
BRD-K05104363_PD-184352_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21151
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1633
NAGLU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712039
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.478923
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15466
BRD-K64606589_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MANSC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00742221
BRD-K79090631_CGP-60474_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K61431055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23777
pyrroline-5-carboxylate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.125
DAUDI	CCLE Cell Line Gene Expression Profiles	1.0	1.54746
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41457
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08929846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47935
BRD-K74710236_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
S100A9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.871
Rad51C-XRCC3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
FCAMR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625876
BRD-K21937603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09606
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
initiation	GeneRIF Biological Term Annotations	1.0	null
NQO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459691
POLR3A_01_139	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.70229
BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79997957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02409
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.855555
MTA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547886
THRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837568
migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.347511
Chronic obstructive pulmonary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
identify	GeneRIF Biological Term Annotations	1.0	null
CXCL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00916839
TOB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00816506
GSU	DepMap CRISPR Gene Dependency	1.0	2.17134
CMPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00894085
YRDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541904
BRD-K90049800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.9679
combination	GeneRIF Biological Term Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.78382
FDCSP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522521
BRD-K01554997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37443
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069342
JHOS-4	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.05196
monastrol-610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A16820783_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IFT172	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577429
CHST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430004
pempidine-2172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A25337146_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92571446_WZ-3105_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92571446_WZ-3105_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04349
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.5046
BRD-K48059443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1384
BRD-K02822062_CT-200783_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.13216
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00733737
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8823
ARSG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055789
WNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789545
BRD-K88510285_B675700.cdx_SKM1_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00796963
HSP90AB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531258
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HS729	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81382
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1967
BRD-K27049948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36506
MHC class II protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
BRD-K04548931_EPIRUBICIN HYDROCHLORIDE_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GPR132	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477359
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.0182
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040328
BRD-K87909389_HY-10005_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BE-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K99749624_S1003_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5358
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434906
SPRED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567423
Gastrointestinal endocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
CCM2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681649
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.82647
17571080-SuppTable2a	GeneSigDB Published Gene Signatures	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5357
BRD-K98490050_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585157
BRD-K95672029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03288
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9612
BRD-K76353834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26939
TP53RK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656077
D-336MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64742
EW-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-U74615290_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DOV13	DepMap CRISPR Gene Dependency	1.0	2.06121
Acute Myeloid Leukemia_LAML_TCGA-AB-2834-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-6689-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
fulvestrant-7490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DEFA3	Pathway Commons Protein-Protein Interactions	1.0	null
Sperm glycocalyx	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
Prostate adenocarcinoma_PRAD_TCGA-KK-A8I4-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70714754_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79090631_CGP-60474_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K30326216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9016
EPSTI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059721
CDK18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00729435
SLC25A10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564558
BRD-K93662118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23419
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.901432
496100671_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.3184
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
NUAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00919141
Crohn's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
BRD-K95901403_S1118_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KAP1-22055183-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041507
Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6666-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIV encephalitis_frontal cortex_GSE3489	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.20828
CI1	CCLE Cell Line Gene Expression Profiles	1.0	1.55022
BRD-K64800655_PHA-793887_HS578T_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53903639_480743.cdx_HA1E_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADAMTSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00743856
sirolimus-402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PSMA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00803528
TRIM24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00794363
TRIP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480446
Granulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.221
solasodine-3749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
antimicrobial humoral immune response mediated by antimicrobial peptide	GO Biological Process Annotations 2025	1.0	null
AGMAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613132
BRD-K23984367_sorafenib_HME1_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36778976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57867
BRD-K70487031_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mucosal immune response	GO Biological Process Annotations 2025	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11168234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3733
hsa-miR-3670	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-U82589721_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K26304855_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet4-RNAseq_SJIA_KD_up_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13566078_BMS-345541_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76293260_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15146
GIMAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442308
HIST1H2BM	Pathway Commons Protein-Protein Interactions	1.0	null
Vesicle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K54233340_Dorsomorphin dihydrochloride_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVOL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615872
UFSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00704934
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.5683
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16315
STK39	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0087887
BRD-K74402642_Chemistry 2804_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AKR1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00398543
SP110	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501356
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.3436
CSF1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00685531
response to external stimulus	GO Biological Process Annotations 2015	1.0	null
NDUFA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585841
defense response to Gram-positive bacterium	GO Biological Process Annotations 2025	1.0	null
SIN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0112038
TMIGD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640419
bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K90655269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67335
PIK3R4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066886
BRD-K64559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40595
BRD-K88510285_B675700.cdx_HCC515_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838858
MAP3K2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545633
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864327
COL4A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00902177
TMEM163	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488995
BRD-K30298864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47983
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06402
BRD-K93229898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05476
BRD-K22915992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65031
LMCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705385
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5378
BRD-K11636097_S1249_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MS4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663842
PITPNM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725779
TXNRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669119
Lung adenocarcinoma_LUAD_TCGA-55-1592-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522792
GABRR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506382
BRD-K04546108_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92571446_WZ-3105_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00996621
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.37611
Golgi lumen	GO Cellular Component Annotations 2025	1.0	null
BRD-K00615600_AG14361_NCIH1836_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
faecalis	GeneRIF Biological Term Annotations	1.0	null
BRD-A98203122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44507
who	GeneRIF Biological Term Annotations	1.0	null
extracellular space	GO Cellular Component Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-K1-A3PO-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.986925
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100310_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.55559
PRMT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608201
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A83P-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A57474391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.093
SZT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00802232
BRD-K52321331_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Specific granule lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
COLO-668	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K50045638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79802
iocetamic acid-3022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STAMBPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828379
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.087227
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3913
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17140735_-666_CL34_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
innate immune response in mucosa	GO Biological Process Annotations 2023	1.0	null
VHLL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00831436
PMC8601278__F3	PFOCR Pathway Figure Associations 2024	1.0	null
SLC5A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00354514
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039914
Rostral migratory stream	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065444
GAL3ST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635072
SETDB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522071
BRD-K00615600_AG14361_PL21_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53547009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.0502
BRD-K64800655_HY-11001_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2653
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8055
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.161922
BRD-A52530684_DOXORUBICIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colon mucinous adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
BRD-K64800655_PHA-793887_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CYP2B6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0078757
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42333
BRD-K83670234_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	1.41279
PRM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0095052
BRD-A18497530_EI-293_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17609687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13115
bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.121379
NKX2-5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0140178
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041028
BRD-K92431275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95932
FJX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601704
BRD-K85606544_neratinib_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43389675_DAUNORUBICIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-ID_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.76022
OCILY3	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
BRD-K91011325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25015
DNAJC5G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682444
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
response to biotic stimulus	GO Biological Process Annotations 2015	1.0	null
496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.87908
RNASEH2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664665
BRD-K42918627_GSK-2126458_MCF10A_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.839737
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38209615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62506
BRD-K78659596_MLN2238_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
defa13	GeneRIF Biological Term Annotations	1.0	null
BRD-K05649647_-666_HA1E_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655541
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.38377
P2RY11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00814146
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99545815_HY-10459_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFE2L2_01_60	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.15222
CASR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487297
INSRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00734194
BRD-K79090631_CGP-60474_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12502280_TG101348_NCIH1836_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87909389_alvocidib_HS578T_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A88461048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23725
P2RY2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741438
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.089456
CD74	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00953963
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113689
BRD-K23192422_L-6307_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
probenecid-4185	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88510285_B675700.cdx_A375_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5851-01A-13R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUCLG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622312
BRD-K15803157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0391
BRD-A52886023_A8674_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93747373_HG-5-113-01_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22533
BRD-K00259736_Colchicine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26375
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05976
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.335864
PTPRO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00906783
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067858
BRD-K47599758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63588
ENTPD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0126111
HAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500407
CACNB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621167
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.462
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04988
BRD-K36397874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18046
corn silk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
KDM4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459249
BRD-K19687926_lapatinib_SKBR3_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A41250203_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17561142_AMIODARONE HYDROCHLORIDE_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23963854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11323
hsa-miR-330-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
IGLC6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83213911_PF 750_LOVO_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adult respiratory distress syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
BRD-K87023633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15213
BRD-A75301702_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92093830_Doxorubicin hydrochloride_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68041793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20677
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880634
3-acetamidocoumarin-4426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC3382229__F5	PFOCR Pathway Figure Associations 2023	1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
Agammaglobulinemia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
GJB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722255
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6999
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838858
BRD-K78658063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12839
CASP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00376917
PMC3852967__F3	PFOCR Pathway Figure Associations 2024	1.0	null
primary lysosome	GO Cellular Component Annotations 2023	1.0	null
BRD-K71799778_BML-259_EFO27_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041654
golgi apparatus part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NCAPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447959
BRD-K83670234_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1245
tocilizumab_homo sapiens_gpl6244_gse25160	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K98548675_Parthenolide_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Leukemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
SRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066802
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.78059
IRAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558849
BRD-K47998973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13014
being	GeneRIF Biological Term Annotations	1.0	null
JHH4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59446
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108348
cellular_component	GO Cellular Component Annotations 2015	1.0	null
VPS45	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670573
CYP24A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100516
IRF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00728229
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64291
Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
Myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.399
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
IDH3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00973289
RECQL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643856
BRD-A91461229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.31716
HL-60	GDSC Cell Line Gene Expression Profiles	1.0	1.8797
AAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674471
NDUFS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00836074
HEXIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521176
ZNF365	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590146
antimicrobial humoral response	GO Biological Process Annotations 2023	1.0	null
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075709
SASH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0105295
endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.239197
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88288
BRD-K08547377_irinotecan hcl )trihydrate)_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PARVG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00402851
BRD-K00907050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02637
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K18619710_Digoxigenin_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42145213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63029
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14021
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A18497530_EI-293_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
NCIH647	DepMap CRISPR Gene Dependency	1.0	2.90905
DLG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635306
BRD-K09499853_KU 0060648 trihydrochloride_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052772
BRD-A41692738_TGX-221_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.74272
RNASEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051715
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.266
SCABER	DepMap CRISPR Gene Dependency	1.0	3.4051
ULK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065321
promazine-2173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SETBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058888
VEGFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629935
ORAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744742
HIST3H2A	Pathway Commons Protein-Protein Interactions	1.0	null
CSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0080952
ALDH18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00380872
BRD-K53192330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08209
hyoscyamine-2108	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F8-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20312
NDUFB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609812
BRD-A07861932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69226
CDR2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602665
DVL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490368
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00022
EP300	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519154
BRD-K88625236_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K20416270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58374
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46755
crypt	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.965928
NQO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00806138
BRD-K13390322_AT-7519_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1578
BRD-K82928847_rocilinostat_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTSG	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K99122228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23812
HMOX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539024
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
17597811-SuppTable7	GeneSigDB Published Gene Signatures	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_H1299_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33098168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51455
CRCGN017_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16219
ITPKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512323
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99749624_linifanib_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IDH3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00823959
BRD-A19633847_PERHEXILINE MALEATE_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K31222955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.057
mrc5sv2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02365
BRD-K13387373_Thonzonium bromide_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CBR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00410072
BRD-A22783572_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28165749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5469
NEK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00481147
CRCGN015_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08545
BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
BRD-K90241462_Chlormadinone acetate_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Senescence_frontal cortex_GSE1572	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.82078
lumicolchicine-4195	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KE37	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94794
coli	GeneRIF Biological Term Annotations	1.0	null
17785550-SuppTableS2	GeneSigDB Published Gene Signatures	1.0	null
antibacterial humoral response	GO Biological Process Annotations 2025	1.0	null
BRD-K64890080_BI-2536_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.547
PL21	CCLE Cell Line Gene Expression Profiles	1.0	2.40871
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71726959_N9-isoproplyolomoucine_HA1E_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K09460582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39298
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51905
dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054206
CHD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576403
GRB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676454
PAPSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609337
Basophil percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.80969
BRD-K66733186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27904
BRD-K75076471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27055
BRD-K88485670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40619
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
BRD-K78126613_MENADIONE_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
against	GeneRIF Biological Term Annotations	1.0	null
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HCC1171	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6552
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611297
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15619
THADA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561908
BRD-K28184331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08724
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.570443
BRD-K13566078_BMS-345541_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34595193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2965
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9989
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38537
BRD-K29163534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11294
BRD-A94756469_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
interleukin-23 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.821
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70875
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5370-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WSU-DLCL2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
RELT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656472
TMEM82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00820957
JAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00700043
BRD-K06666320_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595461
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.43885
BRD-K66270896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11359
BRD-K68495784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10066
mRNA_MYCN_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NEK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619926
BRD-K31660953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51982
MAPK14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476451
upregulated	GeneRIF Biological Term Annotations	1.0	null
RARRES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562996
STYK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00796643
BRD-K74148702_curcumin_VCAP_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A60513937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11746
IL36RN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725963
Gynostemium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
FOXN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2786
DANG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35842
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
HIST2H2AC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A72703248_SKF 96365 hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16802067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19195
BRD-K78126613_MENADIONE_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26711
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17696
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48566
VSTM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00857102
PAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0078813
RGS7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00743638
BAX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00398877
AKR1B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633099
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37914
BT549	CCLE Cell Line Gene CNV Profiles	1.0	1.7166
BRD-A36630025_-666_NCIH1836_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99545815_PF-562271_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
LMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557869
CHAGOK1	CCLE Cell Line Gene Expression Profiles	1.0	1.48133
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RNF123	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697069
BRD-K39688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34251
Vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.547
RARA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655206
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
response to lipopolysaccharide	GO Biological Process Annotations 2025	1.0	null
peripheral	GeneRIF Biological Term Annotations	1.0	null
BRD-K92991072_PAC 1_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30256
BRD-K83963101_MLN-8054_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A79465854_auranofin_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10597
BRD-K58930048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64934
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6903
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.798
Azurophil granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
antibacterial humoral response	GO Biological Process Annotations 2015	1.0	null
BRD-K24132293_piperlongumine (HPLC)_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.988952
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5157
IgA glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
SLC39A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00886042
RPL17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0114928
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48761
BRD-K61323504_sb 225002_PL21_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.0989
ALDH3B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055916
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.917396
BRD-K43389698_BMS-387032_MCF10A_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Promyelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.42
LIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679662
BRD-K60483981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34341
BRD-U33728988_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HIPK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00867299
NCAPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061433
BACE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544429
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
BRD-K06666320_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNFSF13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744391
SLC5A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539633
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.14732
SAA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00716548
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.896724
HLA-DOA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00761832
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	7.41611
BRD-K30436657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75287
BRD-K99749624_S1003_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13390322_AT-7519_MDAMB231_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JNK_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GJB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00771723
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.08595
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
BRD-K80786583_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622702
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18565
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K79090631_CGP-60474_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CMTM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0112045
BRD-K81418486_vorinostat_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
naloxone-5243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76703230_YM-155_HEC108_6.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92241597_CHR 2797_HCC515_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058894
BRD-A43331270_niguldipine hydrochloride_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00697169
BRD-K00835182_Betamethasone_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72048
BRD-K74402642_Chemistry 2804_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCOA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501749
BRD-K05886700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34879
TLR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521152
ZNF668	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0120362
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22523
BRD-K94109423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20125
IL17D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00827557
LOXIMVI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06666320_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRKG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506262
TNKS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0115178
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.978241
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57665
BRD-K65752097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50397
BRD-K68174511_torin-2_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K00615600_AG14361_SKLU1_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03562091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01145
CCDC181	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00990914
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.613
granulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.892648
peptide	GeneRIF Biological Term Annotations	1.0	null
IL2RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520419
BRD-K18812295_Chrysene-1,4-quinone_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27050140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46512
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.844888
PDE7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727428
BRD-K15620114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61938
BRD-K49669041_HY-11005_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34519525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13403
biological regulation	GO Biological Process Annotations 2015	1.0	null
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2904
BRD-K79090631_CGP-60474_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HIST1H2AJ	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5275-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00865018
BRD-K34489277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14421
Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837365
displays	GeneRIF Biological Term Annotations	1.0	null
AFD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00919425
EB2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61326
BRD-K49371609_528116.cdx_NCIH1694_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GYPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0175614
IFNA17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00996978
gynoecium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.259591
lytic vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.139785
BRD-K79090631_HY-11009_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10705233_GW405833 hydrochloride_RMGI_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TAAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646728
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42157
BRD-K60230970_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACVR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560269
PM20D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00954626
CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PIGW	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615679
CDKN1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645017
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.5
PIGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057713
HLA-A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574249
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JD-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2244
BRD-K89574562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92872
cytoplasmic membrane-bounded vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
Dental plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.960216
PDE6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070334
CH25H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657727
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.03132
BRD-K05197617_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD59	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502505
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
leukoplakia	GeneRIF Biological Term Annotations	1.0	null
HT1197	DepMap CRISPR Gene Dependency	1.0	2.62427
ETS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.003802
BRD-K11636097_S1249_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685013
HUS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596882
ACSM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548916
Golgi lumen	GO Cellular Component Annotations 2023	1.0	null
T cell migration	GO Biological Process Annotations 2025	1.0	null
LY-294002-5576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MASP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624343
hsa-miR-2276	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K02371763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14038
EVSAT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48188
monorden-493	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
infection	GAD High Level Gene-Disease Associations	1.0	0.298214
CTLA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574402
Perturb_14161_KD_BZW1/BZW2_SRP316321	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.93224
IL12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084597
MCMBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477977
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15929
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9321
BRD-K18909381_CGS 12066B_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00766318
BRD-A64774838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37755
BRD-K48803730_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84320538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4208
Central element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.678
Secretory granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.084
BRD-A06352508_SB 218078_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KCNQ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395276
BRD-K64165176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02177
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
BRD-K50836978_Purvalanol A_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GIMEN	DepMap CRISPR Gene Dependency	1.0	4.08829
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28412
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00994419
GJB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665752
Specific granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NPC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00444553
mRNA_GADD45A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MPIG6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492806
BRD-K05649647_-666_HA1E_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GJA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501087
PSMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547112
LOXL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00355924
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GLUL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0111399
LDHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778155
Leukocyte adhesion deficiency 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
SLC25A37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.012614
ESRRG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586057
KIF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733297
Obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-A20213616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.15759
BRD-K45631723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0122
BRD-K70549064_EI-156_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K25075258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05558
BRD-K79090631_CGP-60474_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PACSIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689957
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.638
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15414
brinzolamide-6670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CFHR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680598
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30617
BRD-K94176593_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36575476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41436
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
BRD-K64634304_Retinoic acid_SKM1_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Jejunal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
cell part	GO Cellular Component Annotations 2015	1.0	null
BL70	DepMap CRISPR Gene Dependency	1.0	2.50396
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56424158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15095
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.665
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.861575
immune system process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1016-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q0-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dengue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56854
BRD-K83988098_S1142_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDKN2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502803
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38533
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
CGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536345
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49602
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.6069
MTX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580138
BRD-K54906270_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VEGFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00886261
BRD-K27305650_LY-294002_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K26664453_-666_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A23955117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34881
defense response	GO Biological Process Annotations 2015	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
MDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495864
response to lipopolysaccharide	GO Biological Process Annotations 2023	1.0	null
FCRL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663155
IL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588654
saos-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328628
BRD-K74402642_Chemistry 2804_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IGLC1	Pathway Commons Protein-Protein Interactions	1.0	null
GAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484271
MXRA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487674
BRD-K46121327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68147
BRD-K81322049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11382
extracellular region	LOCATE Curated Protein Localization Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDKN1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649163
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K77634326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70267
BRD-K99545815_HY-10459_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ileocecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.264696
ETNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054115
BRD-K18190982_COT-10b_SKLU1_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CXCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615632
BRD-K46306993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19257
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5795
HRH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642836
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042438
style	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.299242
methylergometrine-6704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
RIOK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00735707
KCL22	CCLE Cell Line Gene CNV Profiles	1.0	1.92033
SLC16A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613615
BRD-K81418486_vorinostat_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
defense response to bacterium	GO Biological Process Annotations 2025	1.0	null
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.505
BRD-K57080016_-666_HT115_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12343256_trametinib_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RIDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624987
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.185016
BRD-K91900765_VX-745_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDUFB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00865553
BRD-K07368164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51421
RUNX2	ChEA Transcription Factor Targets	1.0	null
CDK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00841276
SNU245	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
IFNA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637917
BRD-K86472598_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488719
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K82135108_elesclomol_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_753_KD_ABAT_SRP385901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.16268
TAPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00811555
SKNMC	CCLE Cell Line Gene CNV Profiles	1.0	2.11916
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582552
Specific granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.678
KCNH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625517
BRD-K35852282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08517
bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178682
BRD-K09875820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28717
18425577-TableS3a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K60623809_SU11652_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Immune System	Reactome Pathways 2014	1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.41469
BRD-A36630025_-666_A549_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EW-22	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41833
PTPRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00901236
TNFRSF18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548495
BRD-K34776109_glimepiride_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.028036
BRD-K08679933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29734
LYPD6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550483
PMC5069771__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045899
HTR2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00880806
BRD-K64800655_PHA-793887_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.821393
PPIP5K2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00814055
Urinary system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
used	GeneRIF Biological Term Annotations	1.0	null
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.940628
ATP2B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048187
ZNF141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733174
Staphylococcus aureus infection	KEGG Pathways 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8479
BRD-K98824517_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTGIR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626779
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22096
SCN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809299
CEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00765244
BRD-K64862162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10272
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24703
BRD-K78431006_HY-50878_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09185
AVPR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524189
BRD-K21450593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83578
YY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632942
IgA glomerulonephritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
BRD-K63068307_ZSTK-474_LNCAP_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCI6A	DepMap CRISPR Gene Dependency	1.0	5.09747
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20508
ZBED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517714
BRD-K41859756_-666_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNFAIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00736144
BRD-K54256913_-666_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39396484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17529
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SYK_knockdown_279_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.66563
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2ME-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63970901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48665
hsa-miR-544	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
DPP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675372
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00946
bone marrow	HPA Tissue Gene Expression Profiles	1.0	2.21936
FTCD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049871
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45592
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.92198
PDE6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491354
BRD-K64857848_XMD-885_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21672174_Ro 28-1675 ?_SKLU1_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dental caries (decayed and filled deciduous teeth)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
ETS1_01_244	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.76212
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Meningioma	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K77290793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17572
TRIM27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677181
XCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504378
CDC42BPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505496
SNAI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00810061
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACNA2D2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773241
BRD-A19037878_trichostatin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Immunodeficiency 38	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-K05002317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11435
cellular response to lipid	GO Biological Process Annotations 2023	1.0	null
ERGIC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104396
SUFU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629052
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15493
FLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00846899
iv95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.328
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03234
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04016
BRD-K04757670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45577
CHRND	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063736
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35427
CDK17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00723646
BTBD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696703
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53259
chronic	GeneRIF Biological Term Annotations	1.0	null
IL21R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504938
CRCGN009_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16095
BRD-K74512976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11261
HHLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584365
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IGF2BP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555659
SNU119	CCLE Cell Line Gene Expression Profiles	-1.0	-2.14984
antimicrobial humoral response	GO Biological Process Annotations 2015	1.0	null
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.873694
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4248
Lassa Fever Virus_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.94192
BRD-K92059157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07637
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15706
BRD-K49371609_528116.cdx_HT115_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5163-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0557
BRD-K13390322_AT-7519_MCF10A_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05635176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40354
KMS21BM	CCLE Cell Line Gene Expression Profiles	1.0	1.75348
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4817
20436685-ST5-2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K92571446_WZ-3105_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Microscopic Polyarteritis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09468
NCF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611059
FXYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0151302
BRD-K53417444_OTSSP167_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL18RAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0118752
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1429
NOMO1	CCLE Cell Line Gene Expression Profiles	1.0	2.6951
PDPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564576
dihydrostreptomycin-2237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49371609_528116.cdx_OV7_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCAR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644568
CTNNBIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617122
POU1F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578118
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07561
SPATS2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00749768
LYZ	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP140	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679989
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9786
CFLAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00420998
SYNCRIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595884
SVEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614862
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8632
Ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
SLAMF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100548
BRD-K62533881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3241
GLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0118288
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060986
SYK_knockdown_280_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.58671
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7595190-41598_2020_75453_MOESM6_ESM.xlsx-MLL_EFS_groups_DEGs-Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
MKN7	CCLE Cell Line Gene Expression Profiles	-1.0	-2.21574
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
BRD-K17349619_HLI 373_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K90259198_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23478508_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A11350423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.899
ACOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605477
BRD-K98772859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88442
BRD-K51290057_Ch 55_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ML-2	GDSC Cell Line Gene Expression Profiles	1.0	3.60177
KDM4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00474795
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8271
cytoplasmic vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K55187425_ON-01910_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37601439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13084
LY-294002-401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-WK-A8XY-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPY5R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499127
NME8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00732004
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87304
blood	GeneRIF Biological Term Annotations	1.0	null
NDUFB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00869991
SPG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00922322
BRD-K64634304_Retinoic acid_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUSP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106611
Tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
BRD-K13390322_AT-7519_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TICAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078648
DACH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00866023
EDA2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545462
TTBK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050182
BRD-K37687095_AZD-8330_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
BRD-K80577041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33825
GALK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591059
BRD-K93537437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52392
BRD-K52075040_-666_HA1E_24.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A37704979_SB-203580_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCI30	DepMap CRISPR Gene Dependency	1.0	4.08576
ALDH6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00750672
BRD-K64890080_BI 2536_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
oral	GeneRIF Biological Term Annotations	1.0	null
CRCGN013_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19779
VPS4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00378366
BRD-K19220233_JNK-9L_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUTM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067941
HPAFII	DepMap CRISPR Gene Dependency	1.0	5.29794
IL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444843
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
secretory granule lumen	GO Cellular Component Annotations 2023	1.0	null
NDUFV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00761424
BRD-K20853228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12849
THP1	CCLE Cell Line Gene Expression Profiles	1.0	1.91981
PNU-0230031-4291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K00615600_AG14361_PC3_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paneth cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.24
carpel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261284
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11977
JL1	DepMap CRISPR Gene Dependency	1.0	5.07596
BRD-K23984367_S1040_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02108
Lung squamous cell carcinoma_LUSC_TCGA-22-5472-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00927721
BRD-K92571446_WZ-3105_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DICER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774005
guaifenesin-3814	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518115
NHLH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00833191
CD19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058153
KCNJ12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524297
BRD-K36883526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04286
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.64453
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69903018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40394
BRD-K32882942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52675
BRD-K66254772_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.1641
BRD-K53414658_-666_H1299_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MPZL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00456523
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
IZUMO4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006228
SLC4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104829
IPPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00474395
BRD-K48593237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56378
MRPS18A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719706
defa	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2023	1.0	null
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0357
BRD-K17210248_S1216_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29678
COLO684	CCLE Cell Line Gene CNV Profiles	1.0	1.62669
osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079797
BRD-K49371609_528116.cdx_PL21_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FKBP11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575929
Golgi lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.694
Secretory granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.825
BRD-K38615104_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93788137_PF-431396_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CARD14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627149
BRD-K98005735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62789
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.932583
BRD-K13169950_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular response to oxygen-containing compound	GO Biological Process Annotations 2025	1.0	null
yy1_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.025454
BRD-K27915221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82758
BRD-K79877849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08766
BRD-K11636097_S1249_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet3-array_SJIA_KD_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
butoconazole-2427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MKN28	DepMap CRISPR Gene Dependency	1.0	5.63365
secretory granule	LOCATE Curated Protein Localization Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92638
Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62096
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.975255
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34509
BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sputum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
PPP2CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809834
SLCO1B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619917
MARK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0125671
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40576
IKZF1_01_138	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.48897
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6041
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054477
JMJD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067739
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.638
Tertiary granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.48
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85162396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.097
before	GeneRIF Biological Term Annotations	1.0	null
orphenadrine-2318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K47366416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.16094
BRD-K12539581_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.542764
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
UBOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574896
BRD-A28746609_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
niridazole-5682	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC35C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00858419
antifungal humoral response	GO Biological Process Annotations 2025	1.0	null
BRD-K50140147_HY-10192_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525311
CDK11A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00428307
BRD-K54233340_Dorsomorphin dihydrochloride_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYO5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587888
ZC3H7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564096
LDHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0037848
prilocaine-3624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FCSK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772107
SLAMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00799853
BRD-K37940862_NCGC00185684-02_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K13390322_AT-7519_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70301876_Escitalopram_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22602
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.127654
Calprotectin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.155
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT1-17558387-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98157055_SIB 1757_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00921984
ZFHX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593273
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89978
BRD-K72414522_AZD-5438_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HIST1H2BF	Pathway Commons Protein-Protein Interactions	1.0	null
TRAF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521576
BRD-K85101688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25865
BRD-K52157065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37081
Primary lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MCAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87795
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0935
IDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721231
KDM1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00929078
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.88385
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050839
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3258
HIST2H2BF	Pathway Commons Protein-Protein Interactions	1.0	null
PRTN3	Pathway Commons Protein-Protein Interactions	1.0	null
GPRC6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523516
TMEM255A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0109849
WDR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780796
SW780	GDSC Cell Line Gene Expression Profiles	1.0	1.43056
BRD-K13566078_HY-10518_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489892
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43396
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.552
BRD-K99545815_PF-562271_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYBBP1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570293
SLC18A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100097
SRMS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567261
KNS-81-FD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LIPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511216
BRD-K61662457_CAY10594_A673_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K59369769_HY-10161_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K97183783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79324
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05763
RAB39A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00815601
BRD-K56700933_PEITC_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IKZF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00746469
BRD-A19037878_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gastrointestinal system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
LAMB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605569
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2278
EOMES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571664
BRD-K54233340_Dorsomorphin dihydrochloride_OV7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K81651477_Parthenolide_PL21_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.690451
GMPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477665
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3063
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6232
membrane-enclosed lumen	GO Cellular Component Annotations 2015	1.0	null
BRD-A04618830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.89071
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7747
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96263742_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40733000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18253
NOL4L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719014
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31230200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51471
tetramisole-2489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSC39	DepMap CRISPR Gene Dependency	1.0	2.88248
BRD-A52024592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34446
Mucoepidermoid carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
tanespimycin-432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Night sleep phenotypes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
defense response to fungus	GO Biological Process Annotations 2025	1.0	null
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.349
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.120175
DKK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605898
BRD-A20314546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05153
BRD-K91701654_70970_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51535
Myelofibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0574
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17307
BRD-K79090631_HY-11009_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLAIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00774084
SLC26A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442336
Sarcoma_SARC_TCGA-WK-A8XO-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00456903
SELE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00993454
CD300LG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626195
KLRC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667662
BRD-K13169950_NSC 3852_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64763786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09583
BRD-K72296840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36334
BRD-K83270677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66179
BRD-K47794327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07466
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05982
BCL2L14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006626
MDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055196
BRD-A89434049_SARMENTOGENIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VNN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078284
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TNFRSF13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597862
BRD-K65242613_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37687095_AZD-8330_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
multi-organism process	GO Biological Process Annotations 2015	1.0	null
BRD-K80622681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24287
BRD-K20142115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79721
MAP4K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491358
NCIH1693	CCLE Cell Line Gene Expression Profiles	1.0	1.42125
BRD-A59985574_T542500_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76694128_DCC-2036_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71726959_N9-isoproplyolomoucine_SW948_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75331656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25956
HIST1H2BN	Pathway Commons Protein-Protein Interactions	1.0	null
JUN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00420247
econazole-2396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37507671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83521
BRD-K47109712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77225
BRD-K13566078_BMS-345541_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.73736
bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.547
haptoglobin-hemoglobin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.988
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02547
BRD-K10906552_7887507_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31647
BRD-K37206356_RHAMNETIN_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GLRA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060576
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041032
mesentery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.166571
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6087
P3H1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508778
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4925
SPINK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683832
UACC893	CCLE Cell Line Gene Expression Profiles	-1.0	-2.64523
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2087
KDM2B-26808549-CHIP-SEQ-DND41-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC2814	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57635
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
not applicable_asthma_GSE43696_369_mouse_bronchial epithelial cell	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.178277
BRD-K93747373_HG-5-113-01_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.634093
BRD-A67788537_Salermide_RMGI_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03185
BRD-K12035825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34645
BRD-K91039552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20827
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6318
BRD-K25504083_C8273_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A20697603_598226_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OCIAML2	CCLE Cell Line Gene Expression Profiles	1.0	1.70127
BRD-A20697603_T8902_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13684_OE_JMJD3_SRP151752	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ADPGK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590646
TGM2_KD_GSE23702_716_human_NB4 cells, 72h ATRA-induced differentiation	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K35347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42315
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-A60245366_AS-601245_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94012289_OSI-027_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FFAR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00857454
APAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660737
BRD-K46124507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19376
PCSK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00888223
stigma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.461078
ALAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00307502
BRD-K31883758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44813
BRD-K78599730_manumycin A_SKLU1_6.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.071873
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92334
IL4I1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712948
BRD-A61825514_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNASET2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623577
PFKFB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597817
defense response to fungus	GO Biological Process Annotations 2015	1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041988
BRD-K19269952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4077
BRD-K01877528_TL_HRAS26_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AADAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00678718
BRD-K42150052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01509
WDR72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00859312
ZNF280B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00954132
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.558
HIST2H2AA4	Pathway Commons Protein-Protein Interactions	1.0	null
BIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698504
sulfafurazole-5622	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21064560_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51978501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95986
ZFHX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713887
SLC29A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00723172
MS4A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640731
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Differentially_expressed_genes_of_RORC_cluster_RORgt_DC_compared_to_other_clusters_in_each_dataset_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
PRAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00764256
BRD-K28377013_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TEAD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0075461
HIPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661759
GABRA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502395
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TMEM52B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0120173
QPRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00341266
NOTCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00415181
decreased	GeneRIF Biological Term Annotations	1.0	null
GNMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00826739
EZH2	ENCODE Transcription Factor Targets	1.0	null
TESK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603735
BRD-K49371609_528116.cdx_SNGM_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58547240_7856827_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	1.33935
BRD-K05137000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.88827
SLPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576883
BRD-K54606188_(+)-JQ1_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZC3H12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564268
mbl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
cell killing	GO Biological Process Annotations 2015	1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068894
BRD-K99369265_S1039_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Developmental and epileptic encephalopathy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
azurophil granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.573828
specific granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.4608
BRD-K08799216_pelitinib_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A79768653_sirolimus_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PADI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00813532
KCTD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051499
COL4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528934
BRD-A58280226_Y27632_SKMEL28_6.0_h_4.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233446
SKGI	DepMap CRISPR Gene Dependency	1.0	3.96675
lymphocyte chemotaxis	GO Biological Process Annotations 2025	1.0	null
UBQLN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708276
BRD-K21680192_mitoxantrone_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ALDH3B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586821
SGK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00786913
ECC10	CCLE Cell Line Gene CNV Profiles	1.0	1.78687
P31FUJ	CCLE Cell Line Gene Expression Profiles	1.0	1.95587
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40576
20418243-SuppTable1a	GeneSigDB Published Gene Signatures	1.0	null
496100382_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04893
BRD-K37486644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26235
BRD-A14878925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03261
IL2RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591725
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83428
BRD-K14599588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05894
Vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.743
PITX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693606
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6268
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet3-RNAseq_SJIA_KD_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FOSL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696511
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.96
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47017
KCND2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00893361
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38576
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24385
BRD-K38477985_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20332
BRD-K45746021_CC-401_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99545815_PF-562271_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.653807
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18619710_Digoxigenin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94W-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VPS37B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581835
myelofibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.428891
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47498351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21924
BRD-K54233340_Dorsomorphin dihydrochloride_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GUCY2F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494844
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.547
ARHGEF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521033
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
BRD-K00300115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11552
GCT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
16140871-SuppTable7	GeneSigDB Published Gene Signatures	1.0	null
MORN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00724596
BRD-K39858575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64671
SNU81	DepMap CRISPR Gene Dependency	1.0	3.20072
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17223
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36385
adenomas	GeneRIF Biological Term Annotations	1.0	null
Innate Immune System	Reactome Pathways 2024	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04736
SUPT11	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49685
BRD-K21025364_NVP-TAE226_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043928
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD48	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665517
BRD-K25842662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19898
HTR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551452
CTRC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00952142
20371479-TableS2	GeneSigDB Published Gene Signatures	1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9497
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	6.30272
AIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546925
BRD-A94756469_DIGOXIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDH6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475521
SBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0106328
BRD-K92795658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16865
PRDX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613967
haloperidol-1539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72292
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36511
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.901432
KIRREL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00948296
tonsillitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.17421
GZMM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475357
HCC202	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36538
BRD-K99198579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18823
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910514
COX7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00859587
PMC8567035-CTM2-11-e578-s001.xlsx-transcription_misregulation-RUNX1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
20038735-TableA3	GeneSigDB Published Gene Signatures	1.0	null
therapy	GeneRIF Biological Term Annotations	1.0	null
BRD-K88890050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23892
BRD-K71726959_N9-isoproplyolomoucine_A549_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ICC2	DepMap CRISPR Gene Dependency	1.0	8.66885
malignant	GeneRIF Biological Term Annotations	1.0	null
Alpha-defensins	Reactome Pathways 2014	1.0	null
cSARS Bat SRBD_30Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.58463
ACTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625044
HDAC6	ENCODE Transcription Factor Targets	1.0	null
ANKRD44	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00721625
ANO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589886
BRD-K92317137_-666_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ANXA1	Pathway Commons Protein-Protein Interactions	1.0	null
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60873
BRD-A90643929_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32927008_7021926_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IGHG2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51503
HT-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22956
BRD-K13390322_AT-7519_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86638309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09909
496100371_TCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38383
risk	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21672
BRD-K49075727_nintedanib_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40293
BRD-K50345393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.5082
BRD-K49371609_528116.cdx_HA1E_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64800655_HY-11001_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3158-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K08799216_pelitinib_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPHN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0114883
BRD-K20624967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23104
Cecal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
SIRT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00842053
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
remoxipride-6503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKM1	CCLE Cell Line Gene Expression Profiles	1.0	2.13763
SLITRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416367
BRD-K76703230_YM-155_RMUGS_6.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A05883068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03514
Mammalian defensins	InterPro Predicted Protein Domain Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OX-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dermatitis, atopic;	GAD Gene-Disease Associations	1.0	null
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7439
BRD-K78659596_MLN2238_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73858940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38816
RHOBTB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060866
SLC12A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00940596
ARHGAP24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00683812
CNR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00381849
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
BRD-K48935217_S1364_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.880858
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02036
STAT1	Pathway Commons Protein-Protein Interactions	1.0	null
HSD17B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677531
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.110096
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.36955
HIST1H2AH	Pathway Commons Protein-Protein Interactions	1.0	null
SLC4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693756
PTGFRN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728721
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.09982
BRD-K88378636_withaferin-a_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EHBP1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00942055
CLCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511671
PDE4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00843325
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9473
FAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00301527
RGS13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007143
SST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650946
SAMSN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650196
BRD-K13390322_AT-7519_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K18307373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13857
ICOSLG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067252
BRD-K97462883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26501
STAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00755059
BRD-K41859756_-666_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16543
Prestwick-675-2187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.203361
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FNTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00909508
BRD-K13566078_BMS-345541_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PDE1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524282
BRD-K75130046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70124
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20917
Specific granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.842
S100A8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.956
PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84595254_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K74797618_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857927
NOD-like receptor signaling pathway	KEGG Pathways 2026	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_PC3_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100482_PCx_no dementia_TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00028
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K92138166_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A93236127_DIGITOXIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696253
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K53561341_KIN001-220_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
peritoneum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.137542
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6369
BRD-A71459254_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PCTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590817
MPO	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A11605036_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CUL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00897678
BRD-K91810283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69976
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4064
CHMP2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0107113
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045106
Dengue hemorrhagic fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
cervical epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.794375
BRD-K66580188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89603
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09017
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617934
SET2	DepMap CRISPR Gene Dependency	1.0	3.14248
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ETNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593813
POLR3H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00749978
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.786
Golgi lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CCNE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00381988
BRD-K24132293_piperlongumine (HPLC)_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UACC893	DepMap CRISPR Gene Dependency	1.0	4.66342
BRD-K14907323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11636
MAP3K12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514559
BRD-K13390322_AT-7519_LNCAP_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular response to lipopolysaccharide	GO Biological Process Annotations 2023	1.0	null
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1399
BRD-K55696337_Topotecan_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU61	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55443
BRD-K88573743_A443654_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PNU-0230031-3629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88008216_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32131036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28932
BRD-A79465854_auranofin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CYP20A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00435251
MAK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588666
riluzole-3666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MSMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627755
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60625
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
phagocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.31596
BRD-K85401814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46161
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QC-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
azurophil granule	GO Cellular Component Annotations 2023	1.0	null
BRD-K60762818_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.246
BRD-K61388138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02119
Brain Lower Grade Glioma_LGG_TCGA-HT-7693-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MUC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516793
FGFR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650619
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5813
immune	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98092
BRD-A68930007_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
BRD-K21680192_mitoxantrone_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93788137_PF-431396_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99749624_S1003_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LAMA84	CCLE Cell Line Gene CNV Profiles	1.0	1.43027
HCC70	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.05196
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3179
BRD-K21680192_mitoxantrone_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	1.0	1.38293
AKT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00289062
EPHA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00915588
BRD-K05979026_NCGC00241726-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1727
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
WNK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00443308
CRCGN014_HEPG2_3H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04357
BRD-A02481876_Importazole_HEC108_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
transformation	GeneRIF Biological Term Annotations	1.0	null
BRD-A36630025_-666_HCT116_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45569026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27312
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC11A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706125
IFNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658803
BRD-K31542390_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A27844016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4073
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3724
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.917396
BRD-K88573743_A443654_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A43575461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12007
BRD-K06543683_Ro 31-8220 mesylate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71262871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64182
BRD-K49075727_nintedanib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CMTM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805836
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55615
SOX10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0071014
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.13098
BRD-K13094524_PFI-1_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSG	BioGPS Cell Line Gene Expression Profiles	1.0	1.41726
golgi lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053366
BRD-K64052750_gefitinib_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CAMK2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638115
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49865102_PD-0325901_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65719
REG1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0068609
BRD-A43330902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26813
GPAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532549
acute	GeneRIF Biological Term Annotations	1.0	null
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.78678
JM1	DepMap CRISPR Gene Dependency	1.0	3.9391
KPNA3	Pathway Commons Protein-Protein Interactions	1.0	null
Gingiva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
BRD-K02078126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66127
VPS9D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00734858
BRD-A93206962_L 755507_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFP90	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00902168
BRD-A41451487_PK-11195_HA1E_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A23723433_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AOC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00816063
TBCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00770076
NCIH2126	DepMap CRISPR Gene Dependency	1.0	3.49246
CBX3	Pathway Commons Protein-Protein Interactions	1.0	null
496100373_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21719
BRD-K53417444_OTSSP167_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07877311_7811943_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GJB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00769359
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24507
BRD-K78633253_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MS4A4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0088551
BRD-K54233340_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64147309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09122
CBLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052469
Nephritis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
BRD-K24132293_piperlongumine (HPLC)_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49040541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70648
BRD-K54233340_Dorsomorphin dihydrochloride_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLK2_knockdown_87_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.73432
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8019
BRD-K92571446_WZ-3105_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83438939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85757
B4GALT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502325
BRD-K70914287_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
characterize	GeneRIF Biological Term Annotations	1.0	null
BRD-K31688005_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PELI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537661
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0831
IRF7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530175
BRD-K04548931_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K09366011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04189
BRD-K01436366_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PINK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0116547
PRKCZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00897184
SK-MEL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RHOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603399
BRD-K28907958_-666_RKO_6.0_h_11.1000003815_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABRR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507636
BRD-K50075939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11027
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17464
BRD-K71726959_N9-isoproplyolomoucine_AGS_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6502
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31989
BRD-K95760042_2512-0754_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NADK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00723066
ULK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551689
SLC29A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600584
Ileal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
BRD-K04623885_BIBR1532_A673_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10753
BRD-A39996500_radicicol_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874593
BRD-A54927599_KF 38789_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TUBA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757512
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5646
PMC11732233-mmc1.pdf-336-TCF3_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
polycythemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.389281
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.27556
Colonic epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.285
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
XCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00899361
Mixed Salivary Gland Tumor	DisGeNET Gene-Disease Associations	1.0	null
BRD-K88569143_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.0794
skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043011
BRD-A35588707_TENIPOSIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28742
BRD-K88388723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59123
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0115543
IFI27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0042527
A704	CCLE Cell Line Gene Expression Profiles	1.0	1.53213
CRCGN013_HEPG2_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06199
BRD-K96354014_-666_HT115_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LTA4H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673931
tiabendazole-2479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
spiradoline-3818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71566411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27632
BRD-K23478508_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HIST1H2AI	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28932578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1885
INHBC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570724
BRD-K07615667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20637
TIAL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620557
BRD-K88510285_B675700.cdx_SNGM_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCD-8Lu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
alpha-estradiol-403	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW1417	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53249
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02337
PMC11461876-42003_2024_6975_MOESM5_ESM.xlsx-Supplementary_Data_3-Supplementary_Data_3_Differentially_Expressed_Genes_HSE_THP1_UV_Vs_HSE_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
MYRF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103688
BRD-K71823332_S1297_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_WSUDLCL2_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
GPR179	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00323766
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.69091
BRD-K61323504_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Severe COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
velnacrine-6651	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ipf	GeneRIF Biological Term Annotations	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32205
BRD-K57080016_selumetinib_MCF10A_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K29198371_JAS07_003_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATP2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00734298
mRNA_MYBL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
level	GeneRIF Biological Term Annotations	1.0	null
SLC47A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00886894
TP53I3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589021
BRD-K06666320_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
CARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067476
PRKACB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549537
BRD-A23723433_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1111
BRD-K52911425_GDC-0941_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.20098
lymphoid follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306805
BRD-K64800655_HY-11001_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05014
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14106
potency	GeneRIF Biological Term Annotations	1.0	null
NCIH2342	CCLE Cell Line Gene CNV Profiles	-1.0	-2.06599
BRD-K66254772_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618636
RSL1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499068
outer SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908482
Azurophil granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.049
cellular response to molecule of bacterial origin	GO Biological Process Annotations 2023	1.0	null
CTH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010397
ATR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00767022
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06066
NFKBIZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101553
SLC36A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00904622
KYNU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623614
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67769
CYP11A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689849
BRD-K03816923_Rottlerin_VCAP_6.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KCNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467489
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.115
phagolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.52675
intracellular part	GO Cellular Component Annotations 2015	1.0	null
MPP-89	GDSC Cell Line Gene Expression Profiles	-1.0	-1.92667
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K12502280_TG101348_H1299_6.0_h_11.1000003815_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Azurophil granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
albicans	GeneRIF Biological Term Annotations	1.0	null
BRD-K73319967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02289
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.901432
BRAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0126174
NFATC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00719556
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6957
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0868
BRD-K83670234_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAPSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569369
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75365
EEF2K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056947
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hiv	GAD Gene-Disease Associations	1.0	null
BRD-K96263742_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RSL24D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691988
CRCGN009_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06106
BRD-K42125900_S1148_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN014_HEPG2_3H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84541
USB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00782229
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A85860691_chaetocin_SKLU1_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRMT7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00904467
BRD-K30318008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86151
BRD-K13514097_S1120_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE183327,GSE183328_3_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
OSBPL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575431
Gingival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
BRD-A18328003_GDC-0980_MCF7_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.868264
Z chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
BRD-K91966436_Daunorubicin hydrochloride_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K80359388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32745
BRD-K88642841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27017
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04497
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZL-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846701
BRD-K02130563_S1030_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03353
clofazimine-5277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K24337237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30063
BRD-K28820796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47051
KCNJ4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00889994
CLCNKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637659
VPS72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633228
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837365
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.88352
BRD-K40175214_torin-1_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49165
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25454
VMRCRCW	DepMap CRISPR Gene Dependency	1.0	2.58856
PAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00875196
orciprenaline-4831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14098
BRD-K89853033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10668
FCGR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00741806
BRD-K12057390_APIGENIN TRIACETATE_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051634
tooth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
nifurtimox-2908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A54927599_KF 38789_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PROX1_01_06	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.97982
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CDH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555069
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
JAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432797
Acute Myeloid Leukemia_LAML_TCGA-AB-2808-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52552873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83331
Myeloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Human_RORC_DC_signature_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
TGFBR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0128777
KURAMOCHI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35189
ADRA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00418583
organelle lumen	GO Cellular Component Annotations 2015	1.0	null
BRD-A39996500_radicicol_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102239
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4581
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.230801
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44855
HSC2	CCLE Cell Line Gene Expression Profiles	1.0	1.36689
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898491
BRD-K04546108_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
doc1	GeneRIF Biological Term Annotations	1.0	null
EMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676028
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.947291
BRD-K02130563_S1030_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.953984
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21629
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.589
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6474-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061234
CRCGN015_MCF10A.TP53.M_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2484
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989015
JHOM2B	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0177
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049189
BRD-K37433647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09757
CS1	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.05196
AIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698133
METTL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070585
ZGPAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00878812
krt7_21596846_megakaryocyte_progenitor_bone_marrow_lof_mouse_gpl6105_gse24969	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.201552
HCRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598921
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09961
BRD-K08759542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37705
BRD-K50168500_canertinib_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
antibacterial humoral response	GO Biological Process Annotations 2023	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
SRM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712925
humoral immune response	GO Biological Process Annotations 2015	1.0	null
palatine tonsil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.953409
thrombocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.389281
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.926942
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42773
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5244
CYP4F2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504708
ADH1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674182
Prostate adenocarcinoma_PRAD_TCGA-HC-A8D0-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEL9217	DepMap CRISPR Gene Dependency	1.0	4.64463
BRD-K42098891_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K93296644_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8562
MFSD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462322
Juvenile rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04466
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05331
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09449
MEL270	DepMap CRISPR Gene Dependency	1.0	4.2624
PIP5K1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00419977
defense response to bacterium	GO Biological Process Annotations 2023	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.917396
MAP3K21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502781
BRD-K18619710_Digoxigenin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040716
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7533
ascorbic acid-3225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A19962819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60292
BRD-K13390322_AT-7519_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.322414
BRD-K54256913_-666_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64800655_HY-11001_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GAS2L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577998
BRD-K44100512_KIN001-043_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC3382229__F4	PFOCR Pathway Figure Associations 2023	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03449891_foretinib_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SERPINI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586948
BRD-K03449891_foretinib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04719
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40773
PMC12804025-mmc2.xlsx-LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Beta defensin/Neutrophil defensin	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K80232129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41653
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64857848_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67834
Defensins	Reactome Pathways 2024	1.0	null
BRD-K08799216_pelitinib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-DX-A23T-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FCRLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00938295
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04825
defense response to Gram-negative bacterium	GO Biological Process Annotations 2025	1.0	null
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
UHMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640266
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05982
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37822
BRD-K38538662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02083
AML193	CCLE Cell Line Gene Expression Profiles	1.0	2.25277
UBE2D3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00849455
cellular response to oxygen-containing compound	GO Biological Process Annotations 2023	1.0	null
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7695
cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.165217
NCIH1573	DepMap CRISPR Gene Dependency	1.0	6.81874
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69932463_AZD-8055_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056345
CLEC1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.010927
ZFP36L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.013035
BRD-K02708799_GSK-1059615_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K00615600_AG14361_HCT116_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79090631_CGP-60474_HME1_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057825
BRD-K19526797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14267
tenascinc	GeneRIF Biological Term Annotations	1.0	null
ZNF276	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00426044
BRD-K04325154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21895
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-A19037878_trichostatin A_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8283
vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.130538
NREP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00726055
Apical cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.66
BCPAP	GDSC Cell Line Gene Expression Profiles	1.0	1.88315
TMEM117	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416094
Spleen-hematopoietic stem cell	Tabula Sapiens Gene-Cell Associations	1.0	4.20717
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMP23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637947
496100667_TCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.42158
IGF2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00405736
BRD-A19500257_geldanamycin_SKBR3_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LTB4R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00880898
BRD-K21680192_mitoxantrone_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92778217_MEFENAMIC ACID_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
HSD17B7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530696
secondary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.381199
BRD-A18579359_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78659596_MLN2238_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69512
BRD-K30217326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76951
DOLK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00384431
BRD-K79090631_CGP-60474_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOLM13	CCLE Cell Line Gene CNV Profiles	1.0	1.68982
CDK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00877544
YWHAG	Pathway Commons Protein-Protein Interactions	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.014
Bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.852
BRD-K71799778_BML-259_OV7_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07662722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42961
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
1321N1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.642
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02884
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN011_HEPG2_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1332
DNAAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569558
hiv infections	GAD Gene-Disease Associations	1.0	null
BRD-A19037878_trichostatin A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.468
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32246
Glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
BRD-K49669041_HY-11005_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
TRIB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528711
PMC3382229__F5	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K53802078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29849
BRD-K18109695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15762
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43535
CD55	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451859
upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.554791
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-EGR3_EGR3	Rummagene Transcription Factor Associations 2026	1.0	null
EHMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396724
BRD-K05649647_-666_JHUEM2_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02407574_Parbendazole_MCF7_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bacterial sepsis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
BRD-K24132293_piperlongumine (HPLC)_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41895714_AS-605240_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876891
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02722
BRD-K56653679_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86998514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19549
BRD-K85606544_neratinib_BT20_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K30993697_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_MYOD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4257
PMF1-BGLAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00737511
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	1.67015
APOBEC3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00759951
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21235
BRD-A47598013_citalopram_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K00615600_AG14361_VCAP_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92201
BRD-K88510285_B675700.cdx_SKLU1_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03697080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38367
BRD-K79131256_albendazole_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702174
LYAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00950178
Meningeal Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.03
BRD-K12833024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08549
BRD-K53402320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01122
TAL1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74236984_UNC0321_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100451_TCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58824
proxymetacaine-6332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51643438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15237
BRD-K04853698_LDN-193189_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606145
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHT-101	GDSC Cell Line Gene Expression Profiles	-1.0	-1.72116
BRD-A69110666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09489
BRD-K13566078_HY-10518_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.189
IL11RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00782649
BRD-K98164803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32964
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6168
mRNA_T_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WU-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697074
BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1902
TBRG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064681
Azurophil granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.719
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31354
CYP21A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757202
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0775
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
FCAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00761185
BRD-K92571446_WZ-3105_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vesicle	LOCATE Curated Protein Localization Annotations	1.0	null
HLA-DQB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552065
ITPKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00876564
SLC7A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070367
BRD-K37328981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96789
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
IL13RA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591296
BRD-A15798299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50467
BRD-K59955428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6876
BRD-A50675702_FIPRONIL_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57795803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35958
antimicrobial humoral response	GO Biological Process Annotations 2025	1.0	null
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01511
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.47775
Leukopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
CP-319743-7486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A80705936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66504
Secretory granule lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41607
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619888
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8512
Prostate adenocarcinoma_PRAD_TCGA-J4-A6G1-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97764662_P2499_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lung	GTEx Tissue Gene Expression Profiles	1.0	0.941662
PLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00660308
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A51Y-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Defensin propeptide	InterPro Predicted Protein Domain Annotations	1.0	null
PIP	Pathway Commons Protein-Protein Interactions	1.0	null
neck	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101396
BRD-K42757676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01625
PRKAR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00808723
RCSD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599588
organelle part	GO Cellular Component Annotations 2015	1.0	null
BRD-K79983625_DC-45-A2_SNUC5_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028053
BRD-K81814927_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040175
SLC2A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563906
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.82647
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.934829
MFM223	DepMap CRISPR Gene Dependency	1.0	8.901
BRD-A07214340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04979
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC23A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00787492
Ileocecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.64
BRD-K48488978_YM-201636_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GADL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528884
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6139
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56226
Brain Lower Grade Glioma_LGG_TCGA-DU-7299-01A-21R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02708799_GSK-1059615_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K06117861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76318
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49204
CACNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670915
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pleomorphic adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
DGKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066412
Alpha-defensin	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K98161738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3315
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.741327
BRD-K43389698_BMS-387032_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650879
UBE2Q2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675213
BRD-K73723329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65332
SCARB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00478169
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9665
antimicrobial humoral immune response mediated by antimicrobial peptide	GO Biological Process Annotations 2023	1.0	null
CTHRC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689447
azathioprine-5262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561905
TNFRSF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00728196
UBA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655161
defense response to Gram-positive bacterium	GO Biological Process Annotations 2023	1.0	null
BRD-K51313569_palbociclib_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K13390322_HY-50940_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07485
BRD-K25906698_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75857911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56752
ATP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574017
BRD-K83125173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04455
BRD-K78659596_MLN2238_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fat body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K24132293_piperlongumine (HPLC)_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-YC-A8S6-01A-31R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IFNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535947
CREM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00716103
Goblet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.339
BRD-K53780220_N-((1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03549232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60874
BRD-K34254821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41856
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.25166
ZBTB16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00697376
BRD-K57080016_selumetinib_MCF10A_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09699976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03859
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31367
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-A07029265_IPRATROPIUM BROMIDE_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-AAQO-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KPNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0102953
BRD-K99545815_PF-562271_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
XPOT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663624
CD70	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646708
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26323
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.66
Osteogenesis imperfecta type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
BRD-K88510285_B675700.cdx_HCC515_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548906
BRD-K88278225_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1849
BRD-K97332312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01312
antimicrobial	GeneRIF Biological Term Annotations	1.0	null
methocarbamol-2274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CSNK1G1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00715374
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05104363_PD-184352_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SOX4_KD_GDS2193_37_human_adenoid cystic carcinoma derived cells ACC3	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEP83	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0115864
BRD-K78074905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47215
BRD-K42191735_buparlisib_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00944785
ABI3BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104811
imatinibresistant	GeneRIF Biological Term Annotations	1.0	null
NDUFB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00872647
BRD-A29082194_GITOXIGENIN_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25455
CHRNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573117
BRD-K13514097_S1120_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88573743_A443654_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A10417568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44183
STRADB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616982
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831926
BRD-A19633847_PERHEXILINE MALEATE_TYKNU_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-U64521890_XMD16-144_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50140147_HY-10192_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
polymorphonuclear neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.279307
MCM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617933
BRD-K26373865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28836
ioxaglic acid-3528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NSD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576794
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	0.900121
IDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624363
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79142
BRD-K17743125_S1085_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60430111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18021
SIGM5	CCLE Cell Line Gene Expression Profiles	1.0	1.84954
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1017
ITPKC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00795305
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04097
RPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566649
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
ELANE	Pathway Commons Protein-Protein Interactions	1.0	null
tonsil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.644884
BRD-K50140147_NVP-TAE684_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540765
thiamazole-4372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430318
LIPC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00737075
STC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577046
K5	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59398
oncogene	GeneRIF Biological Term Annotations	1.0	null
TSHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00857557
BRD-K49371609_528116.cdx_NCIH2073_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CKB	Pathway Commons Protein-Protein Interactions	1.0	null
IL1RL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00779756
BRD-K76803075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10901
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879862
NKRF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541943
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.047
BRD-K29905972_S1005_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92191804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85034
Lung adenocarcinoma_LUAD_TCGA-55-6969-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCKBR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511335
BRD-K12343256_trametinib_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062393
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.72597
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.5678
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90514
VSIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107403
Prestwick-972-6511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN011_HEPG2_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1955
SALL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00438792
CHRNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601838
BRD-K49371609_528116.cdx_SKLU1_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00782256
BRD-K36176133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02048
POU2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0117672
IEC-18 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WX-01A-22R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68407802_KIN001-055_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU475	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71114
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60028
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HAMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454904
BRD-K88189489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33405
response to other organism	GO Biological Process Annotations 2015	1.0	null
IL1RAPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673678
MDAPCA2B	CCLE Cell Line Gene CNV Profiles	1.0	1.56917
KIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0174402
immune response	GO Biological Process Annotations 2015	1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.862
Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE441T	CCLE Cell Line Gene CNV Profiles	1.0	1.37796
mesenteric lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.274744
BRD-K19220233_JNK-9L_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLFN11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104556
CRP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104883
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.881
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0332
mRNA_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SIMA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67133
GANC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470775
CRCGN008_HEPG2_24H:D02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0013
Interferon regulatory factor 5 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
azathioprine-5627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colon adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
BRD-A75144621_digoxin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K44432556_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00898183
MAP3K14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710178
PAPA syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
Cerebrovascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.547
adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.321181
BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATP1B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0080031
BRD-K45628030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11605
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
fenbufen-3618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
atopic dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.256652
ADAM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00616577
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8467
ATF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484976
SSTR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0038881
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00341
AFG3L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512013
BRD-K81418486_vorinostat_RKO_6.0_h_11.1000003815_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628831
Striated muscle myosin thick filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.256
BRD-K24132293_piperlongumine (HPLC)_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A47109850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25682
dexamethasone_homo sapiens_gpl3921_gse28896	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K52123365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49943
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00239
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47041
BRD-K53903639_480743.cdx_A673_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K89687904_PKCbeta inhibitor_HCT116_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64424704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95395
CAL851	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32762
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF573	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512981
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054783
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K38358574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0485
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07725
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GPR119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602649
BRD-K23363278_CYT997_HA1E_24.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HIST1H2BD	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37213205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18097
BRD-K36460699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01733
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13551
BRD-K54233340_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FDXR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470253
NLRP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00847449
POU2F2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00763991
GSK3B_KD_GDS4305_179_human_HL-60 acute myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13677
Crypt	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.024
ALDH1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396815
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5668
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042169
BRD-K18726304_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC52A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00881753
CRISPLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0089246
SEM	DepMap CRISPR Gene Dependency	1.0	2.70132
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
BCHE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00988692
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.509021
BRD-K50140147_HY-10192_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15291808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05484
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15118
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12155
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34718
FES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00858708
PILRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660314
mRNA_WHSC2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-A17635048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16203
BRD-K19220233_JNK-9L_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNFRSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544308
COPG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772913
BRD-K24133999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09432
BRD-A52530684_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Glioblastoma	HuGE Navigator Gene-Phenotype Associations	1.0	null
HEK 293T	BioGPS Cell Line Gene Expression Profiles	1.0	1.07396
SFXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00977565
Hepatic Cirrhosis_Liver_GSE6764	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.43171
DMBT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12538
ACADSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00975285
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56291
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K54233340_Dorsomorphin dihydrochloride_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FABP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552008
16174304-Figure2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K81931105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15158
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17570530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0038
CHRNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00730212
BRD-K59317601_INK-128_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NELFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00806542
skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065426
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
blood	GTEx Tissue Gene Expression Profiles	1.0	1.91218
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.22625
hemorrhagic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.084777
CSNK1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00408093
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054598
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WW-01A-22R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSD3B7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693323
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98803
BRD-A28105619_curcubitacin I_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BYSL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00956062
structure	GeneRIF Biological Term Annotations	1.0	null
LIMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527281
BRD-K92571446_WZ-3105_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A770-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598656
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.850392
ELOVL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065561
AATK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113446
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
BRD-K12879624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26436
diclofenamide-3366	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO320	DepMap CRISPR Gene Dependency	1.0	2.3763
POLR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663922
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.948148
NRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614208
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IFI16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569402
IMPDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056204
WNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656395
BRD-K90562751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74148
BRD-K82115725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82688
BRD-K92093830_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
except	GeneRIF Biological Term Annotations	1.0	null
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00818942
tumours	GeneRIF Biological Term Annotations	1.0	null
PRKCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641387
BRD-K54095730_CMPD-1_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56653679_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51153795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27582
DDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715161
specific granule lumen	GO Cellular Component Annotations 2023	1.0	null
hydroxyzine-6660	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GEO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.06182
BRD-U00779237_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39649723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5044
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.689226
Blood-neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	5.14688
KPNA4	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREBBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00700562
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K12184916_-666_SNGM_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Antimicrobial peptides	Reactome Pathways 2024	1.0	null
TRPC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0076434
Sarcoma_SARC_TCGA-3B-A9HO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TREM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102105
Lung adenocarcinoma_LUAD_TCGA-38-4625-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFM-223	COSMIC Cell Line Gene CNV Profiles	1.0	2.15465
all	GeneRIF Biological Term Annotations	1.0	null
LYRM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00750917
PTGIS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00805152
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33357
KIJK	CCLE Cell Line Gene Expression Profiles	1.0	1.37166
BRD-K66792149_-666_VCAP_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
15(S)-15-methylprostaglandin E2-7489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SISO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
defense response to Gram-negative bacterium	GO Biological Process Annotations 2023	1.0	null
BRD-U74615290_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-U64521890_XMD16-144_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pre-eclampsia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.158778
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.73115
HIST1H2AD	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19731191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84347
G6PC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521616
meningococcal disease	GAD Gene-Disease Associations	1.0	null
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72485
S100Z	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645589
SYNPO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705176
BRD-K87669982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44128
OC314	DepMap CRISPR Gene Dependency	1.0	2.88439
BRD-A52794651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08412
Lung Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
SRPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0088391
BRD-K30488928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5142
BRD-K52075715_OXIBENDAZOLE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.008378
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.904183
BRD-K40219231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16515
BRD-K87343924_wortmannin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular response to lipopolysaccharide	GO Biological Process Annotations 2025	1.0	null
BRD-K11927976_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIK3R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00948138
PPIG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515302
BRD-K74402642_Chemistry 2804_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00379491
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
STAT2	Pathway Commons Protein-Protein Interactions	1.0	null
SKAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573684
Platelet alpha granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
CYP19A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773311
BAZ1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00840997
Enterovirus 71_4Hour_None_GSE15323	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.06033
BRD-K14673075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50708
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.761
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
BRD-K30707190_PNU 74654_AGS_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
NCIH2141	CCLE Cell Line Gene Expression Profiles	-1.0	-3.29565
BRD-A59145032_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5112
BRD-K96799727_-666_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDLM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.22668
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19129
BRD-K34044309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1919
BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PUM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00732611
VSTM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00850451
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49028
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U8-11A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DEFA1	Pathway Commons Protein-Protein Interactions	1.0	null
Interstitial lung disease 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.425344
GLRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00881933
defense response to fungus	GO Biological Process Annotations 2023	1.0	null
diphtheria	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.434148
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.19158
BRD-K50836978_Purvalanol A_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69328504_L-690,488_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07825644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30328
PMC12198892-pi-2025-0101-Supplementary-Material.pdf-14-DDIT3_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19894101_MST- 312_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SGF29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00760015
BRD-K50704115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60393
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21040167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76989
BACE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532673
BCOR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719706
BRD-K29509140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45058
AURKC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517572
CCL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0086359
STAT3	ENCODE Transcription Factor Targets	1.0	null
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88627
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
response to stress	GO Biological Process Annotations 2015	1.0	null
H2AFJ	Pathway Commons Protein-Protein Interactions	1.0	null
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PPM1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554647
Placenta	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05313
RKO	CCLE Cell Line Gene Expression Profiles	1.0	1.51272
pleomorphic	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.41811
BRD-K00615600_AG14361_SNGM_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AU565	DepMap CRISPR Gene Dependency	1.0	3.13471
BRD-K71512533_S1154_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1172
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.895779
Hemolymph vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
GSPT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052438
NB4	CCLE Cell Line Gene Expression Profiles	1.0	2.04754
MYBPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772611
BRD-K54143708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26692
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HJ-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITGB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639788
Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09991945_GSK-3 Inhibitor II_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.34949
primary lysosome	GO Cellular Component Annotations 2025	1.0	null
CHRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054658
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.795284
Egg white	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.196
DCAKD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482721
BRD-A48631911_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
S100A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681569
BRD-K78599730_manumycin A_SKMEL1_6.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CACNA1F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667683
MST1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00894246
SPCS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00797912
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.271824
BRD-A46747628_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.140855
BCAS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563918
BRD-A55153871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39007
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
Ileum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.631
BRD-K47292239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17271
LILRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705799
MOB3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0112188
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
secretory granule lumen	GO Cellular Component Annotations 2025	1.0	null
Intestinal perforation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27975
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6484
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Unnamed_0_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PTK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725441
CD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004714
Neutrophil extracellular trap	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.78
exacerbation	GeneRIF Biological Term Annotations	1.0	null
CSRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667182
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7098
NR0B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648598
BRD-K68407802_KIN001-055_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2922
IZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.840973
BRD-K91701654_70970_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRGN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00688032
PDK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490317
GSS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.008863
Bruck syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
BRD-K81647657_3-methyladenine_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K89333198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15475
CXCR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00796584
BRD-A20208638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22187
DUSP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00939364
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	1.0	2.66844
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4498
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5581
santonin-3795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_11923_OE_JMJD3_SRP110517	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7857
paneth cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.51902
SLC6A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558906
BRD-K72238567_656402-250MG_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43389698_BMS-387032_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87947369_VX-680_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34640380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00524
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34692
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24614
BRD-K94833531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26434
CLCNKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00464268
Glioma	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K19776718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09463
ARPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430774
BRD-K03015355_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A85860691_chaetocin_SNGM_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH2110	DepMap CRISPR Gene Dependency	1.0	2.00069
C2CD4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691392
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5016
BRD-K13390322_AT-7519_HME1_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96969336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04272
Pyelonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67566344_KU-0063794_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6138
PMC11813851-12672_2025_1910_MOESM3_ESM.xlsx-Sheet1-Table_S2_Results_of_two-sample_drug-target_MR_analyses_for_pancreatic_cancer_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DNMT3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00865849
PELO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00919743
RETREG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604302
disruption of cells of other organism	GO Biological Process Annotations 2015	1.0	null
HIST1H2AC	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5241-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.20574
EPHA10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0102144
diphenylpyraline-2205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39997
BRD-K58853583_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78082598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58317
Primary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.043
BRD-K06792661_Narciclasine_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MMP19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604232
BRD-U51951544_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69496360_7831785_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RHD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070975
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5923
BRD-K74797618_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IGLC2	Pathway Commons Protein-Protein Interactions	1.0	null
CBX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00421821
BRD-K60511616_Pravastatin sodium salt_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K45609222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.16174
ITGB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00938479
16818636-TableS3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K12906962_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
benzathine benzylpenicillin-2939	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88378636_withaferin-a_A549_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
CCDC85B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00378087
BRD-K70154746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14298
BRD-K99749624_S1003_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577508
gingiva	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.503141
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
RNASE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00756031
PMC3852967__F3	PFOCR Pathway Figure Associations 2023	1.0	null
CFTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551254
DCLK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00817698
Vasculitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
BRD-A19500257_geldanamycin_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94409042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14289
TLR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060882
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KAT6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437966
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.75
ITPRIPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638078
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15466
BRD-K09900382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21757
inner CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01717
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92721
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064702
disease	GWASdb SNP-Disease Associations	1.0	0.023626
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7077
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2699
tolbutamide-2320	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56301217_ABT-737_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K09186807_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.123949
BRD-K23957028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08811
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5325
BRD-K33204113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0581
FHL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00374593
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03752
MMAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694954
protein homodimerization activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K77892972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45927
BRD-K93788137_PF-431396_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAVE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.921
BRD-K67036882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06186
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17568
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NPY2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633186
Tertiary granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.551
KCNJ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00683152
OR10V1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00819224
extracellular region	GO Cellular Component Annotations 2015	1.0	null
GNAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555908
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K23831817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29958
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.494378
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1708
GAPDHS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618491
PMC7802183__F7	PFOCR Pathway Figure Associations 2024	1.0	null
20436685-ST4-2	GeneSigDB Published Gene Signatures	1.0	null
AFF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603511
GPR65	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00730288
BRD-K69852452_F1566-0341_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IL3RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00926237
GLYCTK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0083625
Acute pyelonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
BRD-K46599443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64777
IL15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637691
BRD-K35573744_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21680192_mitoxantrone_BT20_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K27354087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55852
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63719
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66322
GPR25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0112211
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29678
RAB11FIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667132
ARIH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581299
BRD-K24471810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41402
BRD-K42098891_PROTRYPTYLINE HYDROCHLORIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GMS-10	GDSC Cell Line Gene Expression Profiles	-1.0	-2.35638
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.067353
BRD-K60839995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89231
IGKC	Pathway Commons Protein-Protein Interactions	1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5311
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92571446_WZ-3105_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bonemarrow	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34852
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5531
SIGMAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103889
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04591
promethazine-6477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37392901_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MR-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARHGAP15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580556
CELA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00982594
HCLS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503337
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K13566078_BMS-345541_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11636097_S1249_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3867
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9513
BRD-K56057104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12578
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.848463
BRD-K74402642_Chemistry 2804_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K20755323_-666_MDST8_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neutrophil_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
Lymphopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
BRD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615682
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
RPS27A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00790484
BRD-K95016030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07722
BRD-K23118252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00155
BRD-K44227013_ponatinib_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CXCL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561013
IL12RB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047597
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.901432
BRD-A87325732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77694
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Right colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.839
PGAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565407
BRD-K49865102_PD-0325901_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
ACTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592287
RGL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044488
BRD-K15694916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11844
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0516
BRD-K67868012_PI-103_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49865102_PD-0325901_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BTN3A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547742
JAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00839464
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1753
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PI4KA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549269
metoclopramide-2315	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52761
Defensins	Reactome Pathways 2014	1.0	null
Respiratory syncytial virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16106
CCNH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00324993
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854696
BRD-K54233340_Dorsomorphin dihydrochloride_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C1S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00927613
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979718
rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.634093
BRD-K75308990_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39997
Nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
periodontium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408212
BRD-A25170757_1-(4,5-bis(benzyloxy)-2-fluorophenyl)-2-(methylamino)ethanol KLK-33_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TSC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00723765
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861475
BRD-A18419789_Etoposide_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CFL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809426
BRD-K45819372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19938
BRD-A19037878_trichostatin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64840743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06341
BRD-K37687095_AZD-8330_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859411
enilconazole-6518	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAL51	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19432
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
A-Vietnam-1203-2004(H5N1)_7Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.96582
antifungal humoral response	GO Biological Process Annotations 2023	1.0	null
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.917363
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9615
BRD-K90059152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34506
MBD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570475
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04047
ZNF263	ENCODE Transcription Factor Targets	1.0	null
ALOX15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677429
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067777
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9016
REST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00475942
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04347
BRD-K50068274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.269
MZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.983971
PTEN_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A52729710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52695