association dataset threshold value standardized value substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11115 Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.48 TSTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59125 COLO783 CCLE Cell Line Gene CNV Profiles 1.0 1.53977 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100444_HIP_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.34829 PMC11185762-media-2.xlsx-ATAC2wk_KD_V337M_intersect_peak-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.848417 SW626 DepMap CRISPR Gene Dependency 1.0 3.0323 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4961-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54565 UNKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38826 GSE94814_2_v_0_reck_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66328 IZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.827666 KCTD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07083 Peak expiratory flow GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4859-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64492 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35663 UDSCC2 COSMIC Cell Line Gene Mutation Profiles 1.0 null caudal putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23367 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DPH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44535 COLO205 DepMap CRISPR Gene Dependency 1.0 3.33298 GNB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71648 display GeneRIF Biological Term Annotations 1.0 null C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.917252 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852168 496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.7118 Brain Lower Grade Glioma_LGG_TCGA-EZ-7264-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null TBX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7189 MZ in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13441 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89588 PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null IZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968198 H3K36me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 68.8283 TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4126 NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 HDAC1 ENCODE Transcription Factor Targets 1.0 null YY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9946 MOLM13 CCLE Cell Line Gene CNV Profiles 1.0 1.62576 extracellular region GO Cellular Component Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29B-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100465_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76295 496100613_TCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00161 GSE61117_0_v_1_trim24_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100569_TCx_possible Alzheimer's disease_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.70185 RBBP5 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YO-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.4386 496100666_HIP_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00328 BT549 CCLE Cell Line Gene CNV Profiles 1.0 1.70085 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29065 FOSL2::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.478 ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.0179 BC3C CCLE Cell Line Gene CNV Profiles 1.0 1.45632 SW1417 CCLE Cell Line Gene CNV Profiles -1.0 -1.62751 496100356_TCx_probable Alzheimer's disease_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.14177 DOV13 DepMap CRISPR Gene Dependency 1.0 2.62538 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66631 MCAS CCLE Cell Line Gene CNV Profiles -1.0 -1.91549 PMC11030494-media-2.xlsx-ST12-Unnamed_9_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null CAOV4 DepMap CRISPR Gene Dependency 1.0 9.35529 NDUFA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5554 C16orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05009 ALDOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56273 Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3349-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null GSE139975_3_v_0_rnf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.5826 SERBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70989 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44708 SNU182 DepMap CRISPR Gene Dependency 1.0 5.04224 NEU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5921 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0297 GSE235644_1_v_0_fasn_mouse RummaGEO Gene Perturbation Signatures 1.0 null upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899383 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9353 Lung squamous cell carcinoma_LUSC_TCGA-21-1082-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10003 MCF7 DepMap CRISPR Gene Dependency 1.0 3.3711 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21228 SJSA1 CCLE Cell Line Gene CNV Profiles 1.0 1.34653 ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.1081 YIPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2497 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16184 496100411_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.79036 Thap11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.3833 NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15853 Intrinsic cardiomyopathy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.556 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.997771 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12629 KYO1 DepMap CRISPR Gene Dependency 1.0 2.63272 cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26495 COLO684 CCLE Cell Line Gene CNV Profiles 1.0 1.67434 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56146 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02028 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 496100546_TCx_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.72317 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89588 GATA1 ChEA Transcription Factor Targets 1.0 null GSE199034_1_v_0_pirfenidone_mouse RummaGEO Drug Perturbation Signatures 1.0 null TKT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54736 GSE112761,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE164508_1_v_0_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08503 ESO51 DepMap CRISPR Gene Dependency 1.0 2.48281 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.29912 KDM5A ENCODE Transcription Factor Targets 1.0 null POU6F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8226 Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954527 BC3C DepMap CRISPR Gene Dependency 1.0 2.32988 Cardiomyopathy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.556 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null TMEM37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34728 DANG CCLE Cell Line Gene CNV Profiles 1.0 2.84447 outer SZ in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.883988 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4 Rummagene Transcription Factor Associations 2026 1.0 null RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.1511 SNU475 CCLE Cell Line Gene CNV Profiles -1.0 -1.75408 Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.8467 RCCFG2 DepMap CRISPR Gene Dependency 1.0 3.60447 SW1116 CCLE Cell Line Gene CNV Profiles -1.0 -1.41797 SNU1076 CCLE Cell Line Gene CNV Profiles -1.0 -2.5869 GSE130956_2_v_1_icaritin_human RummaGEO Drug Perturbation Signatures -1.0 null prostate GTEx Tissue Gene Expression Profiles 1.0 1.45248 Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.3247 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06911 GSE174383_6_v_7_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null CDR2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43382 GSE87862_0_v_1_mov10_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH2023 DepMap CRISPR Gene Dependency 1.0 4.86229 REST ENCODE Transcription Factor Targets 1.0 null RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.8863 JHH-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90037 Innate Immune System Reactome Pathways 2014 1.0 null Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary bacterial infectious disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.671 SP in perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22026 Rfx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.7736 NCIH209 CCLE Cell Line Gene CNV Profiles 1.0 2.18119 496100383_HIP_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.36816 MED27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70863 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60438 20460173-ImmPortAntimicrobials GeneSigDB Published Gene Signatures 1.0 null SW954 DepMap CRISPR Gene Dependency 1.0 3.17033 SNTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99942 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.07629 outer CP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0692 496100456_TCx_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2823 T3M4 DepMap CRISPR Gene Dependency 1.0 2.15653 CNN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90845 PIP4K2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.555 WM88 CCLE Cell Line Gene CNV Profiles -1.0 -1.34034 ATOH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43052 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 96.1634 THP1 CCLE Cell Line Gene CNV Profiles 1.0 1.35142 antimicrobial GeneRIF Biological Term Annotations 1.0 null inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01545 extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 WSU-DLCL2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18 Rummagene Transcription Factor Associations 2026 1.0 null TP53INP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4926 NECTIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50243 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37492 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07747 Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.9774 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55073 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9353 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18383 HAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35932 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.84874 Nkx2-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.77 defense response GO Biological Process Annotations 2015 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43708 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5963 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33208 SW579 DepMap CRISPR Gene Dependency 1.0 2.86738 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8341 496100602_TCx_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.45704 496100422_TCx_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.78427 GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100561_PCx_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.06683 ZNF169 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12441 SSTR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53084 Peritonitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.015 COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13105 SRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5487 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50021 GSE112761,GSE112767_2_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null SKNMC CCLE Cell Line Gene CNV Profiles 1.0 2.06503 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977513 PC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.53188 NCIH2052 DepMap CRISPR Gene Dependency 1.0 3.70887 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07826 defense response to Gram-negative bacterium GO Biological Process Annotations 2025 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.853063 medial intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.85852 G292CLONEA141B1 CCLE Cell Line Gene CNV Profiles 1.0 2.68623 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95625 PMC4858740-ncomms11473-s2.xls-HAdV-D9_Cr1b_Library_2-Hit_name_CENPX Rummagene Transcription Factor Associations 2026 1.0 null SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890269 BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4307 496100388_HIP_probable Alzheimer's disease_no TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38479 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149442_1_v_0_gdpd3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE112761,GSE112767_2_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100283_PCx_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.56181 EP300_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100549_FWM_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.17311 496100332_HIP_possible Alzheimer's disease_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76434 PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18 Rummagene Transcription Factor Associations 2026 1.0 null RASA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33124 GSE168676_0_v_1_dach1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60438 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07663 SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.916622 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.556 Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null H3K27me3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100410_TCx_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.5055 TVP23B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00833 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01365 pyramidal cells of rostral CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.945589 RAF1_overexpression_220_GSE42964 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.52533 BRCA1 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07826 L33 DepMap CRISPR Gene Dependency 1.0 2.25915 ELK1::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7539 Disease by infectious agent DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.671 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null encoded GeneRIF Biological Term Annotations 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.12658 GSE180951_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Heart disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.556 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.556 SUZ12_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NB10 DepMap CRISPR Gene Dependency 1.0 4.1541 TO14 DepMap CRISPR Gene Dependency 1.0 3.09206 496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76394 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.848286 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66088 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4960-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9085 Prefoldin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.298 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853081 CDCA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87035 inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.967579 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885494 ALOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85915 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03409 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877092 GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7423 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leprosy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.671 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.63154 Monocyte count GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.852288 Brain morphology (MOSTest) GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.5301 ONCODG1 DepMap CRISPR Gene Dependency 1.0 2.022 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28739 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null SOX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21902 FTC-133 COSMIC Cell Line Gene Mutation Profiles 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.5061 DAN-G COSMIC Cell Line Gene CNV Profiles 1.0 2.15465 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 60.6789 NME3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59519 NCI-H1793 COSMIC Cell Line Gene Mutation Profiles 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.671 BARHL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0655 496100498_PCx_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.71099 BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.97 GSE150349_0_v_1_msx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.513 NB1 DepMap CRISPR Gene Dependency 1.0 2.37336 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21666 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02028 Sarcoma_SARC_TCGA-WK-A8XO-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Beta defensins Reactome Pathways 2024 1.0 null GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4794 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32362 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.873615 Cervical mucus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.352 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11182 RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7353 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE100528_1_v_0_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SW1271 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 HECTD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84278 RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14944 Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.4548 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22046 GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 59.4822 TBX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7123 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 69.5536 NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4532 RUNX1_01_47 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.95167 paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08582 GATA2 ENCODE Transcription Factor Targets 1.0 null LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03324 Beta defensins Reactome Pathways 2014 1.0 null HCC2814 CCLE Cell Line Gene CNV Profiles -1.0 -1.71071 GSE244072_10_v_8_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null CAL851 CCLE Cell Line Gene CNV Profiles -1.0 -1.52365 GSE193588_1_v_0_pax3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100654_HIP_no dementia_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.93621 antifungal innate immune response GO Biological Process Annotations 2025 1.0 null OSC20 DepMap CRISPR Gene Dependency 1.0 4.91767 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42908 EHF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3032 Signal peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.022 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null JHH4 CCLE Cell Line Gene CNV Profiles -1.0 -2.00688 ELK1::HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9326 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sox3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8127 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.7694 IAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41639 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15853 Prostate adenocarcinoma_PRAD_TCGA-M7-A720-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.94 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2228 GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6575 PMC7940623-41467_2021_21725_MOESM11_ESM.xlsx-Extended_data_table_9_regulons-POU4F1_extended_POU4F1 Rummagene Transcription Factor Associations 2026 1.0 null response to biotic stimulus GO Biological Process Annotations 2015 1.0 null GSE137144_2_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4902-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE130864_0_v_1_tincr_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE65617_0_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01107 MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7091 Foxo3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.4551 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18845 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null response to other organism GO Biological Process Annotations 2015 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977895 GSE150215_1_v_0_etl4_mouse RummaGEO Gene Perturbation Signatures -1.0 null LAMA84 CCLE Cell Line Gene CNV Profiles 1.0 1.36727 FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2424 JM1 DepMap CRISPR Gene Dependency 1.0 2.76134 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3149 GSE247764_3_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100516_FWM_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.72362 HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3255 defense response to fungus GO Biological Process Annotations 2025 1.0 null PGR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7762 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04284 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.935695 ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9636 KCL22 CCLE Cell Line Gene CNV Profiles 1.0 1.9239 MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00752 HIKESHI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24025 RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.6035 Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BACH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.0772 Waist-to-hip ratio adjusted for BMI GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45488 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.952378 antibacterial innate immune response GO Biological Process Annotations 2025 1.0 null OVCA420 DepMap CRISPR Gene Dependency 1.0 6.03692 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.78436 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0581 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7661-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154767_1_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null Triglyceride levels x short total sleep time interaction (2df test) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.839794 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45123 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5102-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100461_PCx_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.63285 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.2294 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.88115 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45103 response to external stimulus GO Biological Process Annotations 2015 1.0 null Innate Immune System Reactome Pathways 2024 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null COLO800 DepMap CRISPR Gene Dependency 1.0 4.95965 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82649 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.978137 GSE154767_4_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8222 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837321 HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6597 DUX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5201 GIMEN DepMap CRISPR Gene Dependency 1.0 2.93505 ZNF677 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.432 PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Immune System Reactome Pathways 2014 1.0 null OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954527 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.830309 HCC1171 CCLE Cell Line Gene CNV Profiles -1.0 -1.85552 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21039 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.73616 Lung function (FEV1/FVC) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.3301 ZNF37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23222 NCOA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59186 MFE280 DepMap CRISPR Gene Dependency 1.0 3.24715 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0448 OCIMY5 DepMap CRISPR Gene Dependency 1.0 3.06488 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34481 ELF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4709 Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.2353 GSU CCLE Cell Line Gene CNV Profiles 1.0 1.59225 Bacterial infectious disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.671 GSE158285_0_v_1_ddx5_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10055465-media-2.xlsx-ST15-Supplementary_Table_15_Bonferroni-significant_results_of_MAGMA_gene_based_association_analyses_EA_-_p_2_67e-06_0_05_18702_genes_AA_-_p_2_63e-06_0_05_18976_genes_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null ECC10 CCLE Cell Line Gene CNV Profiles 1.0 1.63018 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55019 TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 KLF13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.1758 NCI-H740 COSMIC Cell Line Gene Mutation Profiles 1.0 null Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2081 NB17 DepMap CRISPR Gene Dependency 1.0 5.91792 GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null multi-organism process GO Biological Process Annotations 2015 1.0 null Refractive error GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.4 NCI-H661 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDAPCA2B CCLE Cell Line Gene CNV Profiles 1.0 1.4501 dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48715 H3K27me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26567 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.6694 Medication use (thyroid preparations) GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.35229 JHOS-4 COSMIC Cell Line Gene CNV Profiles -1.0 -3.05196 BECN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10751 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15808 UMUC14 DepMap CRISPR Gene Dependency 1.0 2.47485 TECPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20374 GSE151782_4_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null UBE2L6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68787 Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 128.25 ES8 DepMap CRISPR Gene Dependency 1.0 2.98474 Mastitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.242 HCC1419 DepMap CRISPR Gene Dependency 1.0 2.97694 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32316 thought GeneRIF Biological Term Annotations 1.0 null GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.976972 Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A3EE-01A-11R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100645_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53462 SNU620 CCLE Cell Line Gene CNV Profiles 1.0 1.39221 GSE191174_0_v_1_ccdc92_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null Dilated cardiomyopathy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.556 GSE169697,GSE169725_0_v_5_prrx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC2157 CCLE Cell Line Gene CNV Profiles -1.0 -1.42671 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TDOTT DepMap CRISPR Gene Dependency 1.0 2.12928 NKX2-3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80208 Defensins Reactome Pathways 2024 1.0 null H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43659 GATA3 ENCODE Transcription Factor Targets 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.910866 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.952927 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95625 SCNN1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63805 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.865671 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XI-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atrial fibrillation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.516 MM485 DepMap CRISPR Gene Dependency 1.0 4.41431 GSE234340_12_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 VPS26C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44212 496100493_TCx_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2695 NCIH2342 CCLE Cell Line Gene CNV Profiles -1.0 -2.30817 GSE123022,GSE123030_2_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH2087 DepMap CRISPR Gene Dependency 1.0 6.30566 MYC ENCODE Transcription Factor Targets 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null TBX20 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4763 RPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93882 PSMD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24113 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.224 IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9558 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.856781 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20P-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6115 Electrocardiogram morphology (amplitude at temporal datapoints) GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.03979 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48501 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.925588 SP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04138 CLDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61987 NCIH226 DepMap CRISPR Gene Dependency 1.0 2.66869 response to stress GO Biological Process Annotations 2015 1.0 null Heart conduction disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.516 SNU475 DepMap CRISPR Gene Dependency 1.0 2.36482 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.41305 GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -2.08705 EP300 ENCODE Transcription Factor Targets 1.0 null GSE248858_4_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.154 HT29 CCLE Cell Line Gene CNV Profiles -1.0 -1.75185 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28739 Mecom JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.7407 ZFP57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90916 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20996 HPAFII DepMap CRISPR Gene Dependency 1.0 6.90284 PMC10290283-biol-2022-0622-sm3.pdf-244-ZNF787_ZNF787 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4SY-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4819-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100327_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4836 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56146 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO680N CCLE Cell Line Gene CNV Profiles -1.0 -1.42164 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.14939 FAM156B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02947 extracellular region LOCATE Predicted Protein Localization Annotations 1.0 null MZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.937768 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67655 MCC26 DepMap CRISPR Gene Dependency 1.0 2.4987 Immune System Reactome Pathways 2024 1.0 null CCLFPEDS0003T DepMap CRISPR Gene Dependency 1.0 2.3962 Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.3253 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43708 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.07689 HCC202 CCLE Cell Line Gene CNV Profiles -1.0 -1.61592 Prostate adenocarcinoma_PRAD_TCGA-G9-6356-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833666 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GO-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9066 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56915 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.7155 GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837321 Pou5f1::Sox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0076 SNU1077 DepMap CRISPR Gene Dependency 1.0 2.95931 T3M3 DepMap CRISPR Gene Dependency 1.0 2.30649 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC70 COSMIC Cell Line Gene CNV Profiles -1.0 -3.05196 FEV1 GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.05229 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4973-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.6075 PMC5770158-elife-31706-supp3.xls-ISL1_target_regions-Nearest_gene_2_ISL1 Rummagene Transcription Factor Associations 2026 1.0 null NCIH2023 CCLE Cell Line Gene CNV Profiles 1.0 2.34645 MEIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0653 TBX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0987 GSE92614_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1836 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100598_PCx_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42764 Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.733 GSE127790_4_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null KCTD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10243 EEF1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -7.82121 CBX8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDST8 DepMap CRISPR Gene Dependency 1.0 2.62874 response to external biotic stimulus GO Biological Process Annotations 2015 1.0 null NME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09511 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36606 defense response to bacterium GO Biological Process Annotations 2025 1.0 null MDAMB361 CCLE Cell Line Gene CNV Profiles -1.0 -1.42671 ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7041 SNU245 CCLE Cell Line Gene CNV Profiles 1.0 1.71173 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null KINGS1 DepMap CRISPR Gene Dependency 1.0 3.10628 HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.938462 GSE197686,GSE197688_2_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18 Rummagene Transcription Factor Associations 2026 1.0 null ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3051 layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947645 496100593_TCx_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 6.13528 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.958208 PTK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38169 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null CCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52076 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48501 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20019 MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.04813 limitans nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.839554 SW1271 COSMIC Cell Line Gene CNV Profiles -1.0 -3.05196 IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.959696 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03324 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956586 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919807 NFIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57125 496100503_HIP_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.82276 ID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70678 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.861165 NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 CCDC142 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54606 Prostate adenocarcinoma_PRAD_TCGA-CH-5744-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0058 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.1852 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE127790_6_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45127 HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15675 GSE186483_1_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE176093_0_v_1_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.91265 TP63 ChEA Transcription Factor Targets 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null defense response to other organism GO Biological Process Annotations 2015 1.0 null H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPATA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96548 CTCF ENCODE Transcription Factor Targets 1.0 null GSE100316_0_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1178 SLC39A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40268 MSH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25366 8p23 1 copy number variation syndrome WikiPathways Pathways 2024 1.0 null ANKRD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34717 KURAMOCHI CCLE Cell Line Gene CNV Profiles -1.0 -1.41246 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37492 Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UHRF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23322 ST6GALNAC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05547 CBX8 ENCODE Transcription Factor Targets 1.0 null Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.7532 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14296 GSE174383_2_v_7_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.34021 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11030494-media-2.xlsx-ST12-Supplementary_Table_12_Genes_identified_by_MAGMA_as_being_significantly_associated_with_the_internalizing_spectrum_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01001 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03236 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 46.0459 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03992 response to bacterium GO Biological Process Annotations 2015 1.0 null medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25809 LU99 CCLE Cell Line Gene CNV Profiles -1.0 -1.41077 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.910866 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34481 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null MEG01 CCLE Cell Line Gene CNV Profiles 1.0 1.52176 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977513 PMC8192774__F3 PFOCR Pathway Figure Associations 2024 1.0 null Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 51.9917 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.72735 Fish- and plant-related diet GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.1699 GSE188870,GSE188871_1_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZB-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.40949 SNU-449 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89588 SNU61 CCLE Cell Line Gene CNV Profiles -1.0 -1.44255 MCCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69236 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.7221 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F5-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02866 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null HDAC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03569 GSE112761,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAS COSMIC Cell Line Gene Mutation Profiles 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66631 Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13226 HCC70 CCLE Cell Line Gene CNV Profiles -1.0 -2.22975 GATA3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9577 Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 50.5124 CHK1_KD_GSE54268_666_human_MCF-10A GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34962 Triglyceride levels x long total sleep time interaction (2df test) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.2981 496100499_PCx_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.95341 TBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7713 GSE244072_10_v_9_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210885_2_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27541 PBX1 ChEA Transcription Factor Targets 1.0 null Rumen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.005 GATA1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26022 EVSAT CCLE Cell Line Gene CNV Profiles -1.0 -1.58312 Triglyceride levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.609691 SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36606 GSE225141,GSE225143_2_v_3_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null VPS37D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95311 GSE148692,GSE148695_5_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100537_FWM_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.956 496100492_TCx_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38589 Waist-hip index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.822185 defense response to Gram-positive bacterium GO Biological Process Annotations 2025 1.0 null GSE65617_2_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3506 GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EOMES JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6438 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null RNF26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21284 DTYMK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83299 GSE178560_0_v_1_irf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE142232,GSE142234_0_v_2_gcgr_mouse RummaGEO Gene Perturbation Signatures 1.0 null defense response to bacterium GO Biological Process Annotations 2015 1.0 null response to stimulus GO Biological Process Annotations 2015 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5434 GSE210885_2_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE174383_2_v_0_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAN2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49433 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4841 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 AP2M1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0248 PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Number of sexual partners GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.730103 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148692,GSE148695_5_v_4_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE174586_0_v_1_slc4a11_mouse RummaGEO Gene Perturbation Signatures -1.0 null inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40928 TRIM47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21098 Defensins Reactome Pathways 2014 1.0 null DDIT4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59285 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877092 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21039 PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Downstream_NAME_MSC Rummagene Transcription Factor Associations 2026 1.0 null TBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7046 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10204 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5637 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.884353 PMC11906354-41588_2025_2087_MOESM4_ESM.xlsx-ST12-Unnamed_3_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Antimicrobial peptides Reactome Pathways 2024 1.0 null 496100341_TCx_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.80813 ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4217 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.910866 deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52595 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43534 GSE100102_0_v_6_cgas_mouse RummaGEO Gene Perturbation Signatures -1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89588 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J5-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Waist circumference adjusted for body mass index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 GSE240027,GSE240030_5_v_0_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null WSUDLCL2 CCLE Cell Line Gene CNV Profiles 1.0 1.44412 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.86763 EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS81 DepMap CRISPR Gene Dependency 1.0 4.21641 GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null DDRGK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.471 CNOT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82637 496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.80725 TGBC52TKB DepMap CRISPR Gene Dependency 1.0 4.74908 496100463_FWM_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.74798 STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0719 H3K27me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null METTL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84647 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.8428