association	dataset	threshold value	standardized value
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UQCRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07616
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255278
BRD-K75900952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24238
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323941
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE195582_2_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.50528
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20674
BRD-K00020149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49633
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurilemoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
BRD-K65597286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28559
BRD-K19567079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77874
CRCGN015_HEPG2_48H:I22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07491
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.05
BRD-K35156336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71336
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19712167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03784
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24512
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317591
BRD-K34700473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30418
BRD-K64811593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11528
IF-31-RN78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218709
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
extrinsic apoptotic signaling pathway	GO Biological Process Annotations 2025	1.0	null
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.566
BRD-K23533429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01534
BB-94-HN41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259721
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33268483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47699
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2702
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.534604
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09286
A549_Cerdulatinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123347
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7287
BRD-K81450614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60805
BRD-K90133009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00913
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.959
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.726
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192663_1_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41717
BRD-K89376690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10297
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6755
BRD-K29760532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14353
DYNLRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03039
Gimen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85284
OF-19-JH77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200266
BRD-K72646819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20591
BRD-K51972131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62525
DNLZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18409
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456961
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08006576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87681
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247462
protein complex oligomerization	GO Biological Process Annotations 2025	1.0	null
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58861
BRD-K44908610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32164
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266249
PMC10809641-DataSheet3.pdf-181-KDM2A_KDM2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79433629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19105
Mesothelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
BRD-K09261379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11031
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88720906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43818
PMC8088752__F7	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K76337122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71385
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92803674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34517
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09523238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22612
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20929
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2403
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
myopathy, lactic acidosis, and sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
BRD-K32475622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68443
BRD-K29711480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54477
BRD-K41829399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43984
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157383_6_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488177
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.303
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE208435_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70969650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1672
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8190596-mmc2.xlsx-ETV6_mut-ETV6_mut_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10182289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43001
BRD-K09473191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08845
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58037
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.539
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5939
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75999
BRD-K27881972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4821
AC-97-KP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200979
S0-EE-Y737_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202924
BRD-K19573822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31328
CENPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04409
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20466
DHRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36901
HRI-mediated signaling	GO Biological Process Annotations 2025	1.0	null
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14287
BRD-K95712112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14163
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K15280583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08456
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278844
BRD-K66559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.02036
C17orf49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2496
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12986105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.68053
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16459
BRD-K45984211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33883
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.028
A549_G007-LK_1µM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129055
BRD-K88070373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08731
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30283890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04616
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.758481
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206346
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221052
BRD-K87180723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07064
BRD-K27723822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78097
BRD-K76677554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27478
BRD-K68433511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83078
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.88215
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48962
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.807366
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.564561
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07368164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09201
BRD-K07281036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85993
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274733
CE-00-EK89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23872
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258254
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410835
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07827
BRD-K60557007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58073
regulation of mitophagy	GO Biological Process Annotations 2025	1.0	null
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35583
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333779
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315832
GSE185953_1_v_0_tlr3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7612338__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316382
DERL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70363
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-RREB1_mod_RREB1	Rummagene Transcription Factor Associations 2026	1.0	null
NUPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13497
BRD-K74873856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28703
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495401
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spinocerebellar ataxia type 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
BRD-K28545166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50755
BRD-K25675728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49802
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
RFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02152
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14638
BRD-K22599787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42741
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37827
AA-62-OC45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262841
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273376
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09354
SLC7A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00805
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236084
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302363
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258795
TE-27-FF87_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240497
BRD-K36171309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53528
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-54-FR31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216325
BRD-K40674409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03117
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.32601
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88806312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09634
CRCGN015_MCF10A.TP53.M_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03165
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.749
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96208
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4283
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323099
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.84575
BRD-K71452126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85951
PIDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90488
BRD-K17602350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51926
BRD-K44341877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71036
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15157905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16935
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24345
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321543
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.47459
B4GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03467
Intercellular canaliculus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.811
ARSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08685
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2868
BRD-K81501934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45833
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K47337578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14403
BRD-K56234278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60697
Neurofibrillary tangle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59728
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_10_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLITRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19526
BRD-K43186783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20417
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8793_TCP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582865
BRD-K86845405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17141
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0574
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377516
BRD-K76904668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28343
BRD-K36852613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79861
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7212
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5251
MAN2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20056
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brainstem glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.127
GAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19714
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23397
A549_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013977
KMS-11/TKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.685
BRD-K65598536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4849
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3108
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26345
BRD-K35308744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41029
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205939
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cellular responses to stimuli	Reactome Pathways 2024	1.0	null
abnormal vertebral arch morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K58445641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27996
BRD-K89402302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84982
DE-97-IV02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249284
CTDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12767
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40583
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646939
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24719
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.889657
BRD-K52310606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35074
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38386
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73899967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94573
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230912
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.6848
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.89194
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16888
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377944
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9624
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39713
BRD-K25485483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19727
GSE134986_2_v_0_oma1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66207462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02616
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.635
BRD-K98264372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08171
B95-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
BRD-K69031148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13756
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32844
BRD-K44652223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66128
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anammoxosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.06
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12202458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78263
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00823
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16604405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.125
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
enhanced contextual conditioning behavior	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K34519313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35641
BRD-K26026745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30383
GSE121198,GSE129779_3_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34595193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12394
BRD-K24235529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1612
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59087082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37384
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323036
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.503034
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58762810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04952
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
BRD-K59149254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32342
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-51-FB60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.609824
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHLPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1411
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70039231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24736
SLC66A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33752
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3395
BRD-K16940345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16197
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2571
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96440230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01576
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3861
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46369
BRD-K31363949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30487
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217991
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41199
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28255
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44322
BRD-K83294522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61744
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K66572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04996
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Leber hereditary optic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
496100369_PCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27891
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.522
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.766
BD-15-VR68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219822
SNAP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00327
YJU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14673
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K36627718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1513
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59078001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60561
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NPFF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15035
BRD-K50941255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41611
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24615
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.548915
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05756
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92114
BRD-K63964208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62645
PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Combined malonic and methylmalonic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74754874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43655
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45608
FA-52-OO58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301842
GSE141624_3_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57038
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49432
GSE130396_8_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332939
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06291
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.994334
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.13735
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63421
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39336
ENKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10153
GSE147240_3_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41834
BRD-K04269696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08344
BRD-K55478267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11729
TERF2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3689
sw13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275066
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370285
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99462197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57872
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6693
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44505
BRD-A84923154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34539
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50328
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-29-MQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266893
ISOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07183
SW-626 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A88381870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34434
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331137
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.37451
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TC-95-IR96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442191
BRD-K01554997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08228
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
response to iron ion starvation	GO Biological Process Annotations 2025	1.0	null
BRD-K67042874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00149
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.2749
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39516553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43664
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17768
GSE222103_0_v_1_ybx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular signaling cassette	GO Biological Process Annotations 2025	1.0	null
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06177900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11522
BRD-K29420358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30444
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.544
BRD-K85977749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05903
GSE131649_2_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504107
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517251
BRD-K69740275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52006
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.910927
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Combined oxidative phosphorylation deficiency 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
BRD-K95573463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27942
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64923
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25718630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.8732
BRD-K88421348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87101
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.452
GTEx Blood 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	12.817
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.873
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02486
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68421
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.969644
BRD-K79521948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02811
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00852
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.715
BRD-K95160020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68805
MRPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26721
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18381
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26987
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29673910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3759
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K32947579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09685
BRD-K36566880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3507
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422156
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341692
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19852577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15928
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1813
BRD-K72561299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01375
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13929
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0264
BRD-K36196444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26547
QA-07-KC40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21112
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9519
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492117
HFE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00487
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294634
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49087
NT5C3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02436
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03176
EXOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06469
BE-17-CS60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235548
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23051691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00671
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
GSE151782_4_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_2_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.661868
BRD-K03937692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08185
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20268
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2106
BRD-K67609710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04576
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K56783915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72871
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
BRD-K49368687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15619
BRD-K24700188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81992
KLHL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30452
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304485
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86898
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13977555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53551
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2532
BRD-K60107240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83827
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.860543
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
French Canadian Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8485
BRD-K12886565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57172
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
PLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02633
BRD-K74096348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22443
BRD-K94518115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07573
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86923998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40927
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21553
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184408
NAGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41101
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Heart_GSE2596_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83818372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18933
BRD-K35240878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06261
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258183
Eukaryotic translation initiation factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.49
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157585
BRD-K08000110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6787
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61984
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213057
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGTRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0551
DCAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88447
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11843
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62329160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0243
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78493876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2737
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHCHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20336
BRD-K83185986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64987
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02210445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81496
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.765
A549_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145402
positive regulation of mitophagy	GO Biological Process Annotations 2025	1.0	null
GA-16-IU17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301741
BRD-K15907840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81498
Outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K43918582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07281
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367505
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM50A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08183
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
at1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
BRD-K87982677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66067
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
SMARCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15812
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.94165
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1073
BRD-K62369921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34544
EE-32-EY37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253378
BRD-K74963702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11182
BRD-K19969409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34751
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241949
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.603
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00412
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30413
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62175
BRD-K47865468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42349
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.674662
DD-28-MZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240811
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89466
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240625
GSE169590_6_v_5_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mpk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
protein kinase binding	GO Molecular Function Annotations 2025	1.0	null
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11383
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02122
AA-87-EI21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405698
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.589
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292557
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01108
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2184
HSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59047
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3419
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K41192068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.57125
BRD-K92460921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.07116
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K96382853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25568
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.589625
AFDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4395
BRD-K59938516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41514
BRD-A26640795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22583
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59444
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.756
BRD-K31644794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05258
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.20003
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393553
BRD-K35517098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74932
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06392309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87246
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3728595-srep02327-s1.pdf-27-VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55885
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68961
BRD-K89832379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94018
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00611
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_6_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20119884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09663
BRD-K59099886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63597
BJAB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.877
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03607
BRD-K86711517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33432
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2857
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653705
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
Behr syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WDR76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40052
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29623
Organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K88996011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60322
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281296
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72216066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99997
ARVCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62396
BRD-K10404799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09285
BRD-K60905563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06494
BRD-K72071403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24177
PMC9314667-Table_1.xlsx-Regulons-FOSL1_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378148
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222725
LYSP100-associated nuclear domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31317
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.516
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421289
BRD-K29713418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00505
BRD-K40300525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28369
496100659_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23556
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
Zygotene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
mitochondrial outer membrane	GO Cellular Component Annotations 2025	1.0	null
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32739
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76755163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.048
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207438
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2069
Endometrial mixed adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.468963
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285142
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90797575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7841
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628371
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.815847
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.03603
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89461
BRD-K79555196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2212
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.988
GSE126127_2_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26620362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02788
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRE1-TRAF2-ASK1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.529
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07235
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62555617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93743
BRD-K17910820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06949
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30538
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140651,GSE140653_3_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MACIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14362
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.58637
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11448
BRD-K78748401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64077
BRD-K18101567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14915
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254877
BRD-K21332842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43529
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52272
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6306
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
4158_IP6K1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.726796
BRD-K36725646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4921
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
C10orf82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21457
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378411
BRD-K95735693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44161
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489204
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17731
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04074
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64303
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.468214
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.3394
GSE110341_1_v_0_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of macroautophagy	GO Biological Process Annotations 2025	1.0	null
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.86944
CPSF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44956
Cellular responses to stress	Reactome Pathways 2024	1.0	null
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15327
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85775326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02163
BRD-K45307863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59197
BRD-K12853587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1266
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290099
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04154
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51339
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4234
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
4499_LAMB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548005
integrated stress response signaling	GO Biological Process Annotations 2025	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8263
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.4688
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11839
BRD-K91696235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13165
AB-85-YK41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323327
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.01
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98245381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15942
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
BRD-K02802091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12842
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17545
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0834
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0134
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K19161227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21467
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01039
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499101
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12649
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425041
BRD-K03562091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.17109
BRD-K97717496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0153
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.715
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.641
GSE86507,GSE86509_7_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15290974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02132
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93063
ZNF592	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0729
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MSTO-211H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NME3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30761
abnormal ovary morphology	IMPC Knockout Mouse Phenotypes	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424881
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
t69-brown-adipose_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-1.40546
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208567
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.191
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50836
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24138
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38508
BRD-K65464642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17413
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.749
BRD-K18763924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13736
CRCGN015_HEPG2_48H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32977
ORAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86882
BRD-K68162101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3811
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.81924
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6619
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12948
JF-84-QZ64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212644
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.377
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.05924
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3448
BRD-K79159743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30266
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296479
GSE130217_0_v_2_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159206_1_v_3_drd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09416
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79904333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03065
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244956
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321672
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02967
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
TCTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14703
BRD-K34595206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07293
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06539
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.492
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.699378
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40066
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7321
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21777
INTS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12027
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.608
MGAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27684
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235579
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16417
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18942
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2011
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.787951
PMC9134960-aging-14-204042-s001.docx-0-ATF4_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8835964__F8	PFOCR Pathway Figure Associations 2024	1.0	null
LBH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73709
BRD-K12930517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15791
BE-36-FY37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621016
Aerial root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.181
CSRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21659
BRD-K99824630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30894
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
BRD-K09078201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.69505
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84662
Mitochondrial encephalomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
BRD-K89742282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10993
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52631
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366953
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414135
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33748896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39722
MTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00373
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.813055
BRD-K68595406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24216
BRD-K24929039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37621
BRD-K33979719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8333
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04352
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23531
BRD-K32079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91518
BRD-K99482176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80391
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317326
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.588821
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532623
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318257
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73124
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20365
Lysosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
BRD-K80443236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1939
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7614
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
BRD-K52414345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84375
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68853384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66202
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96133500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0749
PDCD6IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03572
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.32979
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.377
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.587144
BRD-K82504878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04257
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.0477
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mesothelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
BRD-K05635176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49259
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61354976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54398
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.91
BRD-K82909038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27112
GSE165174,GSE165175_0_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252281
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05173
d5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
NRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05884
BRD-K41009039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13369
CB-38-AW77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220945
BRD-K55852567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18989
TUBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26837
BRD-K48634117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11275
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207243
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359765
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01558
Cellular response to mitochondrial stress	Reactome Pathways 2024	1.0	null
Mitochondrial complex I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rtg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.687528
BRD-K11726285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19369
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210798
BRD-K71452779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3213
UPK3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10656
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07168
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277352
FST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62047
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LTV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89453
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258736
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34802
1269_CCDC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526543
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267657
NELFCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63997
BRD-K36170758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07748
RBM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4278
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A53463743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52752
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.639853
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27638063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03668
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736683
BRD-K95010912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06745
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4648
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_3_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30392
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27663
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5939
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7054
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33719
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13472
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16976
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.493
protein serine/threonine kinase activator activity	GO Molecular Function Annotations 2025	1.0	null
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MELAS syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365939
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85513726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4491
RIMOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02179
BRD-K94480039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32571
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50593511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0414
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.362
BRD-K77519898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02802
BRD-K64393896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6541
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.50458
MLE-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12841150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13252
BRD-A57594599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06173
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.64309
Neuromast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
Cyanelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.917
BRD-K38946705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45666
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33075
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.89404
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-71-PH39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249907
629_ATIC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.68085
PMC10203545-Table_4.xlsx-LM7_underrepresented-DMRTA1_DMRTA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34095226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18297
BRD-K31836496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24583
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255615
BRD-K77535986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30884
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42791
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352955
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22907
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59560948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25465
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.44
NR2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46747
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70339
BRD-K33098168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29856
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58286708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47525
BRD-K50045741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02612
CRCGN008_HEPG2_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05115
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15559
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247545
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03125
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227336
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CARD8 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.544
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
BRD-K43435656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20428
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20107
BRD-K94647035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78024
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78441
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75775113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30187
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32383
BRD-K15609977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61777
BRD-K42663371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0738
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.559402
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78517
BRD-K94913575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01783
ZC4H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43441
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232469
PMC11639743-mmc2.xlsx-LIN28B-gene_name_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19893
BRD-K04407772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16243
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224904
BRD-K08311368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85622
BRD-K87159315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06353
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67572910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54314
BRD-K43926323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03504
BRD-K89394474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38757
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.655548
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.206
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302927
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428566
BRD-K56915252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74923
Mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.75
BRD-K04462989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58502
BRD-K63754039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25602
TFDP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2262
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.860404
PMC10290283-biol-2022-0622-sm3.pdf-108-MSX1_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01166365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3702
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0083
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K14812927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4771
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.75674
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96485138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17862
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86935536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64005
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.854853
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.671
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19549
BRD-K10459843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35077
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336337
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WDR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14371
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2273
BRD-K18136154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18889
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248442
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11806
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20318
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.8834
BRD-K90060707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04959
BRD-K56857396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16168
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73858940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08365
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8727
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54007898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02733
ZNF722	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30134
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69453266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45677
Isolated mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5119
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511486
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02866760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06345
BRD-K73042446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06343
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14557
BRD-K54836449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49169
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.815982
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95294904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24227
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74896637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34631
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3839
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.752236
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UF-28-DW05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.795151
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein kinase activator activity	GO Molecular Function Annotations 2025	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05123945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1304
BRD-K74987024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53441
BRD-A78125048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63855
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9565
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.4483
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
increased circulating potassium level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42964
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06933
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7808
HAUS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15307
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58154
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Alveolar mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40452322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42009
YE-55-YX75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322311
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25521
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.600186
BRD-K90205159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31638
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07614
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29808
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436611
GATB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45407
GSE86507,GSE86509_3_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71427375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07329
PMC3470785-NIHMS377161-supplement-4.pdf-3-JRK_JRK	Rummagene Transcription Factor Associations 2026	1.0	null
Ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
BRD-K87878529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6535
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79768278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35017
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.583184
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2135
BRD-K17245631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12237
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248471
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13342
BRD-K02395808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49782
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00346
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4052
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136392
BRD-K92180676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48045
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3371
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96209756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25246
FCSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54359
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.781684
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.562659
BRD-K93017276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21447
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EYA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3908
BRD-K52854560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08068
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9861
BRD-K87920761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04071
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55573
DNA damage response	GO Biological Process Annotations 2025	1.0	null
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54769228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10948
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24517
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84586608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49818
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39793
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
BRD-K26361872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16476
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46569
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76921877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0617
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08940439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16619
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32776
BRD-K45916030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00898
PDZD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05189
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66598
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04737
AD-07-YF79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303293
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01337
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358835
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.360051
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1393
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7191
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4121
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64836
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K80690345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19237
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6384
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249631
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.529084
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76899562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22626
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35697
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564236
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37446
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-36-TF52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.614916
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46394
GSE160817_2_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27635
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91426044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65294
PMC7761891__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.2154
BRD-K91239327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03661
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416672
RAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15189
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95558029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04765
BRD-K94018786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13424
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A22502289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65931
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459941
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01972
BRD-K77892972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1264
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15772
CB-69-DJ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33319
BRD-K90902537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04288
BRD-A84695402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51939
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72997741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20855
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0155
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.665
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1165
CRCGN017_MCF10A.TP53.M_24H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16043
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHOP-ATF4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.425
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01085
BRD-K36460699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33447
BRD-K95653016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26322
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Core mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.189
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.599608
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23278
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353191
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217452
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K73859343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17716
TMEM221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0562
BRD-K87812655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12252
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229908
LIN7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26829
BRD-K04325154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52587
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9179
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08607
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41378
CD-16-KY17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494421
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48439
6771_PRKRIP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721506
enlarged ovary	IMPC Knockout Mouse Phenotypes	1.0	null
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74131
abnormal vibrissa morphology	IMPC Knockout Mouse Phenotypes	1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.33042
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67729
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357698
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32882942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5027
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00336
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65135171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20005
PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_1_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ishikawa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.492
BRD-K81669067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24594
NPIPA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17256
GSE157049,GSE157051_6_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37098
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44494
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82115725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46671
BRD-K76618080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85772
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59556
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
BRD-K99962919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0685
TRAPPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04908
protein homooligomerization	GO Biological Process Annotations 2025	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546247
BRD-K60631127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04476
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00562490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68298
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84956158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18001
BRD-K49215099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64425
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46322281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87887
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.807
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274431
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SETSIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8712
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-25-OV46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249298
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.715
BRD-K20199304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48594
BRD-K26423054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77818
BRD-K83801418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43262
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358422
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
extrinsic apoptotic signaling pathway via death domain receptors	GO Biological Process Annotations 2025	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538795
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32087
BRD-K25525067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75135
BRD-K09367542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.401
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79562803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11621
BRD-K57748937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2969
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142388
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6461
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322104
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CPXCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42708
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9341_TSG101_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501846
VMAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01387
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56507
GSE218060_1_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293951
BRD-K05060234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79151
BRD-K67448189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08414
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11516
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-51-WE27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239773
SFXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10601
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52194153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68228
BRD-K78944047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93005
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86584551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3049
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52958
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42662
BRD-K90744477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.5337
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2V2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68714
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69520171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20306
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36706
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13922961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85435
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23405
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274229
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59626557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85283
DUSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53481
JC-24-MC69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253998
BRD-K12115687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46312
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500883
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85235446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17458
GSE53538_1_v_0_cd2bp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02793
BRD-K34425773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03319
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75742
BRD-K41878930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32865
GSE113267_0_v_1_rfx7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8629
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64135153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82922
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.722
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201973
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1909
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225883
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99939085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52834
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264584
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5789
BRD-K60716223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31809
BRD-K50477983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22341
SNPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20967
ODAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52931
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.18
CCF-STTG1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35449
BRD-K71486304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60146
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.936008
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6473
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273187
BRD-K43359161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2943
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28164
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22189
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516123
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00799
BA-66-BL56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281676
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PBXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90603
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211845
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97452545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55345
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47405
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.51
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
Chela	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
BRD-K07489055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04606
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
BRD-K66352426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28856
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-RREB1_mod_RREB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04808
BRD-K58756877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59019
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33697018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49388
COPG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85248
TAF6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02908
AFF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01912
BRD-K50247051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.7767
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.535755
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235550_1_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
LHFPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03722
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32966
BRD-K88437756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87742
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08353229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11548
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0286
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281676
GSE205316,GSE205317_2_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2934
CRCGN017_MCF10A.WT.HP_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02705
BRD-K49203165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00065
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326331
BRD-K69175109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44175
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257594
GSTO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09788
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55227
BRD-K19862308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83098
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1041
BRD-K44833533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23582
BRD-K72034944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06618
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38648
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55921
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261263
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45859834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26653
BRD-K88485670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21088
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.702806
PMC9720390-Table_2.xlsx-Supplementary_Table_2-Supplementary_Table_2_Modulation_of_differentially_expressed_genes_in_groups_receiving_different_doses_of_FTC-TAF_and_FTC-TDF_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88836117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01112
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52094743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14031
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298476
BRD-K85912419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24577
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45341
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93747042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07529
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3745
GSE167546_1_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22412
Cheilitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
BRD-K78907463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58794
BRD-K17259076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66818
OSBPL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04368
GSE201217_2_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SH3BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08537
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chelate leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532481
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585301
GSE206779_4_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62219570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4919
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.802201
BRD-K98474331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28959
BRD-K36557327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57803
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
Superior vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3414_GM2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52016
positive regulation of autophagy of mitochondrion	GO Biological Process Annotations 2025	1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.484379
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03935681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52295
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.50813
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296589
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_11_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36504
death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285131
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29886
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.69
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265601
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88119862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08641
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48327
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13672060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97832
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.382
KRBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16935
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24948
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8817
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34896
BRD-K72194126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06042
GSE142210_11_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF239	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04194
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
kinase binding	GO Molecular Function Annotations 2025	1.0	null
BRD-K39037393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03029