association	dataset	threshold value	standardized value
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21273
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9396
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9351
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55G-1026-SM-48FDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848967
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.2214
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.84008
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN014_HEPG2_3H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2721
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103238
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
meclofenamic acid-1445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	0.875281
rna binding	GO Molecular Function Annotations 2015	1.0	null
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70951
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SO-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Phenylephrine (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0197113
Retrosplenial area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3249
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184767
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6411
GTEX-XMD1-0011-R1A-SM-4AT4C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843351
chr10_125911444_A_G_b38	GTEx eQTL 2025	1.0	3.55774
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34589
GTEX-S95S-0826-SM-4B64N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84177
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
NCIH1373	CCLE Cell Line Gene Expression Profiles	1.0	2.15445
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905168
BICR18	CCLE Cell Line Gene Expression Profiles	1.0	1.79614
p1 part of the substantia nigra compacta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0095
MCF7_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163116
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.958486
Perturb_10951_KO_48J19Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.35785
BRD-A53463743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30949
BRD-A44990218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39758
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KYSE450	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47232
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.07398
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833352
NCIH1435	CCLE Cell Line Gene CNV Profiles	1.0	1.79257
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.96388
BRD-K61033092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34093
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.6721
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3693_KO_GPX8_SRP353993	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.80661
Spondylometaphyseal dysplasia Sedaghatian type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
MCF7_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256095
Perturb_17618_KO_TIP60_SRP386872	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.98291
Perturb_2733_KD_BCKDK_SRP298085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.42764
TMEM168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07852
BRD-K48436333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00521
Perturb_1808_KO_Arhgef2_SRP186268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.48457
mantle zone of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22735
Perturb_10002_KD_FTO_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.17083
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83836
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R9-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU3F2	ChEA Transcription Factor Targets	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89918
Perturb_10015_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.3594
Perturb_12729_KD_INCA1_SRP221667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.82978
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328081
Perturb_14374_KD_SRF_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_3855_KD_CCL5_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0333
BRD-K08828851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72487
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040984
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03009
GTEX-QDVJ-0726-SM-48U1W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830396
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-1326-SM-4JBHR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01319
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R8-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548414
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-USF2_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851489
Perturb_11423_KD_AR_SRP324259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.72266
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.27071
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977397
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.254239
SP1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11052
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14345
GTEX-PVOW-0126-SM-2XCFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08826
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
p3 portion of the substantia nigra pars compacta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12095
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89181
Perturb_5392_KD_FOXA2_SRP019241	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.34583
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156994
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.66562
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03985
PMC7825356-8844261.f3.docx-48-IKZF5_IKZF5	Rummagene Transcription Factor Associations 2026	1.0	null
HUCCT1	CCLE Cell Line Gene Expression Profiles	1.0	1.39642
GATA3	ENCODE Transcription Factor Targets	1.0	null
Perturb_3656_KO_MTHFD1_SRP120974	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.9101
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09829
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46154
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.71007
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.971883
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.872414
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3447
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NEU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68175
MAFK_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LRCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26642
TCF3	ChEA Transcription Factor Targets	1.0	null
PIMREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4413
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887938
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.121
Acute Myeloid Leukemia_LAML_TCGA-AB-2964-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0626-SM-48TDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98764
H3K9me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
C21orf91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07102
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16783
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW-620 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	217.908
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29171
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.277
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3363-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dorsal motor nucleus of the vagus nerve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63048
JAK2_knockout_79_GSE26188	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.87144
Lung adenocarcinoma_LUAD_TCGA-44-6779-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7G-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00011
Perturb_7339_KO_TIP60_SRP386875	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.46575
Lung adenocarcinoma_LUAD_TCGA-05-4434-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-305-HOXA11-AS_HOXA11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NP-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SS-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158732
Perturb_17751_OE_Cdk8_SRP093265	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.76494
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03467
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.988128
SNU407	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58187
SDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573853
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12315_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.9654
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.908795
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829815
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269986
organelle	GO Cellular Component Annotations 2015	1.0	null
PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rna-dependent atpase activity	GO Molecular Function Annotations 2015	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93384
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40402
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAPK14_knockout_14_GDS2693	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.14848
periventricular stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14114
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.0996
A549_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159332
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040547
H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A618-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A1KZ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97525
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_12296_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.85867
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975295
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1715
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.835778
MCF7_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160121
MCF7_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164371
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06576
CRCGN014_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1699
overnutrition	GWASdb SNP-Disease Associations	1.0	0.45525
LILRB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532439
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3728_OE_Fut9_SRP242022	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.10001
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13837_KO_Mov10_SRP091426	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.68947
E2F6	ENCODE Transcription Factor Targets	1.0	null
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19712
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26016896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23443
Perturb_11814_KO_N4bp3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.98805
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.957053
clathrin-coated endocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173219
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86923
Perturb_14760_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.4964
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52449
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.098931
nuclear	GeneRIF Biological Term Annotations	1.0	null
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15052
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8304-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K56563758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22285
r2 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03388
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.964627
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202176
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DND41	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93006
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39482
Medullary reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01557
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835947
SAP30	ENCODE Transcription Factor Targets	1.0	null
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00088
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.891646
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19128
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43089
8-Hydroxyquinoline_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131011
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9435
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04665
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z1-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19231
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114971
CNR_KO_GDS2820_636_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K97487406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39863
coronary artery disease	GAD Gene-Disease Associations	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27063
Perturb_3777_KD_GLI1_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26482
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7353
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63518
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330232
PMC3500769-srep00875-s3.xls-CEBP-Time_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75576005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17203
hsa-miR-3157-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
naltrindole-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12742
BRD-K13788250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84685
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42766
Perturb_16004_OE_HOXA13_SRP107176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.41754
REST	ChEA Transcription Factor Targets	1.0	null
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45X-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10094
BRD-K67734449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01247
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
periventricular stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.36715
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.357
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3070_KO_Asb15_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.21532
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19207
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2889_KO_Mcrip2_SRP302058	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.37841
hsa-miR-4511	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
BRD-K76437403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40144
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2114_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.02621
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832074
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_7597_KO_TENT3A/TENT3B_SRP400572	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K77214724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36257
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36118
BRD-K74988798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0197
Perturb_14809_OE_Ldah_SRP282425	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.1289
Perturb_5112_KD_Med10_SRP325525	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.73004
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90382
MAFF	ENCODE Transcription Factor Targets	1.0	null
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24108193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95347
GATA3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55733
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84C-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57787
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14658
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11703
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830527
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40647
NARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11439
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197006
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12812
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054284
Perturb_7505_OE_ADARB1/ILF3_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.95408
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329569
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921007
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52369
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144385
r9 portion of vagal motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66775
Perturb_2347_KD_ELP3_ERP122258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.07407
GSE108675_2_v_1_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68262
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4726-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40251
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66988
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OB mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31228
GSE249544,GSE249637_8_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.00019
Perturb_3857_KD_COL6A1_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.52634
Perturb_7737_KD_HRSP12_SRP155278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.6474
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30569
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05692
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.77032
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65691
A549_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147264
Striatum ventral region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09523
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26716
BRD-K43375231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46346
adult testis	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14441
BRD-K28399883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05776
colon	HPA Tissue Gene Expression Profiles	1.0	0.914455
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
r7 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79951
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14247
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52136
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_5292_KO_Dgcr8_SRP137730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.34253
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49943
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31978
REST-18959480-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_7463_KD_RBM17_SRP126064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K10398797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41979
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
697	GDSC Cell Line Gene Expression Profiles	-1.0	-1.81765
BRD-K15627143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1064
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32304
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29265
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240277
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectosigmoid junction neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38797
GTEX-U3ZN-2026-SM-4DXUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00854
Perturb_8153_KD_BOP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.62325
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3303
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01524
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62004
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K36149853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87564
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155057
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3075
GTEX-VUSG-2326-SM-4KL1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06401
PMC7387553-41467_2020_17477_MOESM4_ESM.xlsx-B_LPS-stimulated_myeloid_cells-Cis-eQTLs_in_LPS-stimulated_myeloid_cells_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7157_KD_NEAT1_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.7653
BRD-K54224946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14053
BRD-K44307624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19388
AMO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_3487_KO_Kctd13_ERP112326	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.12576
superficial stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60168
BRD-K32595757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05472
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.389391
Perturb_7156_KD_ARID1B_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.4868
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17412
SNU61	DepMap CRISPR Gene Dependency	1.0	2.8122
BRD-K84994827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27238
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27092
Perturb_773_Mut_ACLY_SRP403241	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.06119
PMC11732233-mmc1.pdf-193-PLSCR1_PLSCR1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH322	CCLE Cell Line Gene Expression Profiles	1.0	1.92449
structural	GeneRIF Biological Term Annotations	1.0	null
SLC15A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19023
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21394
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	5.65439
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57879
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0941
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11998
Finding Of Mean Corpuscular Hemoglobin	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_1095_KO_ATXN1L_SRP230198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.08904
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125014
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05263
waist circumference	GAD Gene-Disease Associations	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3879_KD_TMEM164_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.40371
Motor nucleus of trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31343
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03805
MCF7_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185851
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00569
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50G-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78L-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03529
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JO-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018423
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040427
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00474
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37875
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.881392
MAFK	ENCODE Transcription Factor Targets	1.0	null
BL41	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71772
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.225647
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A267-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Clathrin coat of endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
WM115	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45855
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.078948
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82249895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63992
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044064
Lung adenocarcinoma_LUAD_TCGA-55-6975-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.23434
A3KAW	DepMap CRISPR Gene Dependency	1.0	6.96999
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.6598
Meloxicam_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123657
CMLT1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.87505
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.322
EN1	JASPAR Predicted Transcription Factor Targets	1.0	null
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225252
periventricular stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71983
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.881333
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829084
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21295
TE5	CCLE Cell Line Gene Expression Profiles	1.0	1.58742
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70264
Perturb_16923_KO_miR26a1/miR26a2/miR26b_SRP216065	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.6636
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17465
MCF7_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161765
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_8460_KO_IFNLR1_ERP121014	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.46526
NUCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29914
Perturb_3859_KD_DDR2_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.69402
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.65599
Perturb_7507_OE_ADARB1_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.85237
Perturb_10096_KD_AGO3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44799
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphnode_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.89272
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_1097_KO_CIC_SRP230198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.07737
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359511
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31927
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04945
GSE249544,GSE249637_8_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5280_KO_Ddx6_SRP137728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.74035
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77596
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.854434
Perturb_17429_KO_Rbpj_SRP110038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.7344
SIPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0666
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21605
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BI-78D3_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221962
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01715
MZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86725
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020526
Caudoputamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3221
TCF12	ENCODE Transcription Factor Targets	1.0	null
Carcinoma, Hepatocellular_Hepatic Tissue_GSE2127	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.50505
PMC9714459-DataSheet3.xlsx-Supplement_3A-1037_elements_included_exclusively_in_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
6849_PSMB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04026
IOSE80	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00163
EBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1633
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992842
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78692
ASNS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00351933
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.97659
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.978223
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522591
blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7211_Mut_MED26_SRP164752	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.51409
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
CYTH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25375
IRAK1_knockdown_115_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.05703
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.91668
MCF7_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183926
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35451051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38382
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29229
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153563
NRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04435
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.73317
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136415
GSE244199,GSE244200_0_v_1_chmp5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NEIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02214
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3106_KO_Olah_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.4994
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2813-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12681
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838931
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80945
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.35596
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT1376	DepMap CRISPR Gene Dependency	1.0	9.66486
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
LB771HNC	DepMap CRISPR Gene Dependency	1.0	3.23293
BRD-K75621129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58081
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.07745
Lung adenocarcinoma_LUAD_TCGA-62-A46O-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22985
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43672
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242051
0179445-0000-4755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K13901498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44726
hsa-miR-548aj	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
abnormality of the tongue	GWASdb SNP-Phenotype Associations	1.0	0.473486
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4267
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287635
BRD-K30053194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41068
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-NR4A2-sequence_name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938573
MCF7_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201945
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871604
ChIP_NANOG_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26577
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8433
dexamethasone_mus musculus_gpl6105_gse44208	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_11837_KO_Slc45a3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.14387
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79712504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03984
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90245
Perturb_4715_KO_Hnrnpu/Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Perturb_9907_KD_EIF2S2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.10439
Posaconazole_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0290095
Lung squamous cell carcinoma_LUSC_TCGA-60-2706-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NFYA	ENCODE Transcription Factor Targets	1.0	null
pbmc cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314046
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24031
GTEX-TMMY-0226-SM-33HBA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14094
BRD-K37331547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84094
Perturb_794_KO_Tnfaip3_SRP332632	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K95500387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14792
RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.04234
Perturb_5201_KD_Wdr43_SRP132494	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.9016
SW1990_PANCREAS	CCLE Cell Line Proteomics	1.0	3.21016
MCF7_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00972546
BRD-K67426191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41805
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977669
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB157_BREAST	CCLE Cell Line Proteomics	1.0	2.14924
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.857097
ABCB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12989
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.927888
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895862
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50497551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26392
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06149
lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.285086
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
betamethasone-valerate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1574
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anethole trithione_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0252231
CHD2	ENCODE Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2980-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166769
unknown	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5494-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126005
BRD-K96284156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6618
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525847
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3162
GTEX-XUW1-0426-SM-4BOOT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951638
temporal muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30823
Mean corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66289
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08258
Perturb_16697_KO_70L02Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.48774
purine ntp-dependent helicase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904069
Perturb_11922_KD_CD73_SRP197630	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.97699
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15526
Perturb_11927_KD_SMARCB1_SRP127642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.28882
Posterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41375
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_4525_KO_Chaf1a_ERP006640	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.9062
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65053
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013712
MCF7_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133605
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213938
MAZ	ENCODE Transcription Factor Targets	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
thymus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227186
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.8697
Perturb_14873_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.675
Childhood Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889391
Perturb_8923_KD_SMARCA4_SRP267639	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.3979
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
magnocellular superficial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16917
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NRL_Deficiency_GDS2936_629_mouse_Retinas - 2 days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CGTH-W-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_9969_KD_WDR3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.59326
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13693_OE_HEPACAM2_SRP257754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.28324
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149696
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-1.90828
LS-174T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.191
Clonidine (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145889
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
SNU478	CCLE Cell Line Gene CNV Profiles	1.0	1.93225
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042233
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.982389
HPAFII	CCLE Cell Line Gene Expression Profiles	1.0	1.40717
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42960858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33882
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3639_KO_BRD3_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.17769
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Perturb_3854_KO_ITPR3_SRP332879	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.08487
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23083
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45058
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Berberine (chloride hydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0218891
Perturb_12338_KD_TFEB_SRP226507	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.68368
BRD-K74660272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15054
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04531
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839999
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38605
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_14606_OE_NUSAP1_SRP407652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.07651
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33636
JUND_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920184
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32199
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.04648
CRLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28002
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909536
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13515
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54360306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.122
CASKIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05396
artery disease	GWASdb SNP-Disease Associations	1.0	0.112464
MDST8_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.07212
BRD-K21254338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22728
PRPF4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048014
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585212
SUM185PE	DepMap CRISPR Gene Dependency	1.0	3.69054
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238517
TBP	ENCODE Transcription Factor Targets	1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19875
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.695
OVKATE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32736
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.838172
ADAMTS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03083
Lung squamous cell carcinoma_LUSC_TCGA-66-2763-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
TCF12/HEB-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901912
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84573
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.171036
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75380271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50574
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09667
SNUC5_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.72586
Lung adenocarcinoma_LUAD_TCGA-78-7158-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14759
USF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56846
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21535473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99412
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77971
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166498
GTEX-S4UY-1626-SM-4AD55	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60027
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166366
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Parasubthalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30201
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.73272
GSE252857_2_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54901
Perturb_11774_KO_48J19Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.53101
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3404
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15515
Perturb_16357_OE_Ant1_SRP217849	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.50166
FGFR3_knockdown_173_GSE41035	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.08178
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11408861-mmc2.pdf-11-DDIT3_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.107
BRD-K82102352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88246
Coronary Artery Disease	dbGAP Gene-Trait Associations	1.0	0.084201
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.2036
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-A4WN-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9362_KO_FAT1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.64743
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170857
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10002
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FGFR1_activemutant_58_GSE17916	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.47712
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A690-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p3 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00566
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548x	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
MCF7_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143662
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841714
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285734
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17794
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
R3HDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07462
Perturb_17748_KO_Drd2_SRP238905	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.27006
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24148
leukemias	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AI-0826-SM-48TZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10039
central subpallium (classic basal ganglia)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03441
BRD-K06148713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06946
GTEX-NPJ8-0011-R4a-SM-2HML3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879446
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15998
STAT3	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9406_KD_GATA6AS_SRP279802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60144
BRD-K46014293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34768
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040775
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1923
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37936
GTEX-S341-0526-SM-4AD5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88179
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
a431	HPA Cell Line Gene Expression Profiles	1.0	1.10839
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A196-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chaperon	GeneRIF Biological Term Annotations	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Expressive language disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01087
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Trametinib (DMSO_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204919
TEAD4_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29736
MON1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08917
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861979
Perturb_13007_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.42778
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35434
acute	GeneRIF Biological Term Annotations	1.0	null
NOTCH_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048515
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79458
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFC3H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73452
kasugamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00542
Perturb_2331_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.67922
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15870_KD_NRAS_SRP328367	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.58924
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62066
BRD-K96493283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42029
DnaB helicase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.765
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118607
Perturb_11776_KO_Abca8b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.34002
Perturb_4989_KO_Ythdc1_SRP212677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.41868
MCF7_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138756
JHU022	DepMap CRISPR Gene Dependency	1.0	2.56224
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU478	CCLE Cell Line Gene Expression Profiles	1.0	2.14588
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20916
Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39064
NFIC	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FA-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224969,GSE224971_3_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7242-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07477
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205638
GSE137144_2_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70883,GSE71179_0_v_1_pbx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015302
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867038
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.881285
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976242
GTEX-WRHU-1326-SM-4E3K7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889715
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3411-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-0626-SM-3NB1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839919
Perturb_6891_KD_PIRIN_SRP375440	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.8184
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10989
Perturb_8354_KD_PtenTraf3_SRP337419	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.31086
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66314
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51471
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8159
Perturb_16589_KO_Mx_SRP133673	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.12541
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79836
NAMALWA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47276
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7293
Sympathetic nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
hsa-miR-548aj	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GPANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34049
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.03217
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BXPC3_PANCREAS	CCLE Cell Line Proteomics	1.0	7.94141
FGFR3_knockdown_174_GSE41035	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.12381
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.988055
BRD-K08075712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1043
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain	GTEx Tissue Gene Expression Profiles	-1.0	-0.996602
SUDHL6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.21726
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20871
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122225
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5004_KO_Rinf_SRP200002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.94647
mantle zone of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52066
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83535
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88332
HCFC1	ENCODE Transcription Factor Targets	1.0	null
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	2.77346
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7006
Thymic medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.68
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40582
MCF7_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228443
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159273
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93874059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31965
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.87019
ChIP_REST_18959480	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
r9 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94428
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14786
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10443_KO_miR29a_SRP075398	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.35933
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.825122
NCIH2066	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47691
CRX_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96093221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36285
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37278
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0552
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28221
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61189
BRD-K25583354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12044
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19093
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043973
superficial stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01937
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ND-15-RC31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202867
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Oocyte_Embryo_Human	CellMarker Gene-Cell Type Associations	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
helicase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853172
Perturb_2395_KD_TRIM28_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204616
ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.051941
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A463-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4196
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74035
GSE130401_4_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09432998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0856
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33921
CAOV4	DepMap CRISPR Gene Dependency	1.0	2.04129
A549_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149994
OCEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31833
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09356
BRD-K82793574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07201
hl-60 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.296013
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151677
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08719
Sinomenine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0180521
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23451
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179697
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871604
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078765
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98899
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54526
BRD-K67096634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6512
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017048
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79674
YKG1	DepMap CRISPR Gene Dependency	1.0	2.50477
normal	GeneRIF Biological Term Annotations	1.0	null
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268393
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051521
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19197
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942514
A549_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016786
chr10_125918693_A_G_b38	GTEx eQTL 2025	1.0	3.27172
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_11547_KD_PRKAA1/PRKAA2_SRP303942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.37585
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTBP2-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-01A-32R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biomarker	GeneRIF Biological Term Annotations	1.0	null
MCF7_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184005
17880687-TableS3	GeneSigDB Published Gene Signatures	1.0	null
HHV8_72Hour-BEC_20080955_GSE16354	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.41845
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929943
ER-23166858-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27549
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14723
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1711
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99722
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Belzutifan_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0321542
Perturb_12539_KO|OE_FBXO11|FBXO11_SRP278534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.8691
Perturb_709_Mut_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.097
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWN1-1426-SM-48TDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02954
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.674135
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16668
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parasubthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16064
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182578
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244371
hsa-miR-548am	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43325
medial part of r2B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10414
A549_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187356
ZC3H4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2449
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06693
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196354
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844954
Perturb_1838_KO_Phlpp1_SRP151389	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.48678
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16047
BRD-A42536341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46183
GSE126762_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23639
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93075
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-6.74067
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
u937	HPA Cell Line Gene Expression Profiles	-1.0	-0.986264
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3691-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23195
molecular	GeneRIF Biological Term Annotations	1.0	null
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32976
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11488
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998529
BRD-K76899562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28846
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12301
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01228394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46829
A549_Aurora A Inhibitor I_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149672
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38265
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06219
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.37763
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78574
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15537
Perturb_12412_KO_PSMD14_SRP344246	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.88497
EP300_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25926
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03444
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01473
putative	GeneRIF Biological Term Annotations	1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.9157
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.919211
BRD-K12342133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77118
KMS20	DepMap CRISPR Gene Dependency	1.0	3.09426
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.908
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219751
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.31472
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88814
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.84123
GSE148692,GSE148695_5_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.4125
lead	GeneRIF Biological Term Annotations	1.0	null
Perturb_11772_KO_18O10Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.03831
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1387
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8349_KD_MACROH2A1/MACROH2A2_SRP293365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.32283
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.72762
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.202
rna metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	1.0	null
C32	DepMap CRISPR Gene Dependency	1.0	2.5145
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14741_OE_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.57333
Perturb_14588_KD_TCF7L1_SRP094619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.12531
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05617
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19862
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.85791
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260419
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27992
CHTF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13308
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14351
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
u	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
BRD-K95729740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02131
NANOG-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.43225
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133177
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.24837
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKNFI	DepMap CRISPR Gene Dependency	1.0	2.07309
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40663
HEC251_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	7.00078
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04532
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_2-Methoxyestradiol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138123
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22245
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37633
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.972236
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_448_KO_RPA_SRP158719	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.29502
Perturb_9835_KD_GCN2_SRP248465	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.2616
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.949846
BRD-K03141963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72473
Perturb_11407_KD_HNRNPM_SRP143499	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.72803
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rectum	HPA Tissue Gene Expression Profiles	1.0	1.45332
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49391
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309958
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040281
HCC56	CCLE Cell Line Gene Expression Profiles	1.0	1.69664
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5243-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_10097_KD_CNOT8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.34665
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07801
SLC4A1AP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603747
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5147
GTEX-UPK5-0426-SM-3GAEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70586
Perturb_2844_KD_FOXA1_SRP288463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.93772
LY2090314_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0239429
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02467
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19J-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.5025
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23752
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.58068
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52579
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50771
REST	ENCODE Transcription Factor Targets	1.0	null
Docetaxel_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0196919
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138672
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926307
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938017
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38967
u698	HPA Cell Line Gene Expression Profiles	-1.0	-0.824302
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7213
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23781
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228049
SARS-CoV_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67562
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10589
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12723_KD_ARID4B_SRP152296	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.5258
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9592
A549_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203755
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Ellagic acid_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186796
Necrosis	CTD Gene-Disease Associations	1.0	1.1437
GSE112174_5_v_7_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4497_KO_Hnf4a/Hnf4g_SRP139365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.09471
BRD-K60861976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2335
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30575
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8282_KD_BCCIP_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.39537
GSE145323,GSE145324_9_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23502
17880687-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K91683342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17247
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.03235
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73814
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OS252	DepMap CRISPR Gene Dependency	1.0	5.3193
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21184
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859782
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13482
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
OB inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16166
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2518
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
Perturb_13753_KD_EP300_SRP233218	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.14881
Perturb_4908_OE_SNCA_ERP129142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	0.881302
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.905292
BRD-K57293986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03628
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154611
lymphopoiesis	GeneRIF Biological Term Annotations	1.0	null
blood	GeneRIF Biological Term Annotations	1.0	null
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.871133
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.982188
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151836
MHH-PREB-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84669
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63038
promoter	GeneRIF Biological Term Annotations	1.0	null
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299201
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506392
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
periventricular stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56539
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skin	GTEx Tissue Gene Expression Profiles	1.0	0.979911
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922189
changes	GeneRIF Biological Term Annotations	1.0	null
BRD-K63061929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7611
BRD-K37790543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08348
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17338
Lung adenocarcinoma_LUAD_TCGA-50-5072-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.5367
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.950831
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral hypothalamic area, mammillary region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98326
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09359
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07497
Perturb_2318_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62607
TOV21G	CCLE Cell Line Gene CNV Profiles	1.0	1.59756
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4566-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29964
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Red Blood Cell Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02063
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12018
BRD-K82202634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63434
GSE228106_3_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PX3G-0926-SM-48U12	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838151
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.02396
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14983
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40165
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209073
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2167
TCF3-18467660-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
DHRS11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631523
CRCGN015_MCF10A.WT.HP_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01232
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833352
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
hsp60	GeneRIF Biological Term Annotations	1.0	null
Perturb_7376_KD_RBM39_ERP105778	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.68552
serve	GeneRIF Biological Term Annotations	1.0	null
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907196
Perturb_3873_KD_OR10A5_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45814
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_12337_KD_TFEB_SRP226507	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.75849
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU1272	CCLE Cell Line Gene CNV Profiles	1.0	1.76878
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.923947
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10276_KO_31O21Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.69159
MCF7_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127024
GTEX-OOBJ-1526-SM-3NB1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32943
Perturb_433_KO_SLC2A5_ERP118840	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38751
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02855
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15132
MCF7_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164664
dilazep-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78981
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.587514
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.43
HCC38	CCLE Cell Line Gene Expression Profiles	1.0	2.79117
TRIM28	ChEA Transcription Factor Targets	1.0	null
SALL4-18804426_ESC-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Perturb_10095_KD_AGO2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.87045
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17623_KO_PTPN14_SRP153109	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.57445
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7385_KO|KD_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922189
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0912
FOXA2	ENCODE Transcription Factor Targets	1.0	null
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
AKIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7062
BRD-K52842821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31184
Perturb_9837_KD_GCN2_SRP248465	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78549
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
pyramidal cells of rostral CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934746
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148927
HNF1B	JASPAR Predicted Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.953034
BRD-K80593371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08268
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016345
GSE73381,GSE73382_0_v_1_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16372
TRIM28	ENCODE Transcription Factor Targets	1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5847
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40957
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65944
Sarcoma_SARC_TCGA-IE-A4EJ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23944
Perturb_6827_KO|KD_SAM68|NORAD_SRP119826	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.38273
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.132971
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36478
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.44986
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111378
SSR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11232
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4053969-gb-2013-14-7-r81-S3.XLSX-YB1-targeted-genes-gene_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JUND_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9221
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39894
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.093661
RKN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7021771-41467_2020_14684_MOESM8_ESM.xlsx-CASZ1_specific_peaks-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44694
XRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31283
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.034546
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834997
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961735
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.82141
NCIH82	DepMap CRISPR Gene Dependency	1.0	3.05381
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161596
MCF7_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183408
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08805
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.994709
BRD-K22668950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62228
A549_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194697
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NFIC_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67572
NCI H322M	BioGPS Cell Line Gene Expression Profiles	1.0	1.63039
MXI1	ENCODE Transcription Factor Targets	1.0	null
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.8534
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01171
BRD-K24561725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71623
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25242
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06176
Perturb_5649_KD_MYBL2_SRP161768	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.1331
Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10982_KO_Fads1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.74252
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.363
detected	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8291
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72183
r2 part of prepontine raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47474
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.669814
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880581
PMC7021771-41467_2020_14684_MOESM8_ESM.xlsx-CASZ1_specific_peaks-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HEC50B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83615
r10 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.12188
PMC11551338-pnas.2411189121.sd01.xlsx-AHR-Unnamed_0_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16964
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Precursor B-Cell Lymphoblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
Perturb_3649_KO_MTF2_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.69432
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.464
GTEX-XBEW-1326-SM-4AT63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944809
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111276
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141174
DJM-1	GDSC Cell Line Gene Expression Profiles	1.0	1.53348
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VK-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922189
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7383_KO_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.17924
acute myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.243294
Perturb_11228_KO_Srf_SRP050501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.66109
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.12729
Perturb_3842_KD_NUAK1_ERP105460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.98824
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
core part of DTg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64958
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143301
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.0435
Medullary reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07819
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.81903
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.13225
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33142
PMC3500769-srep00875-s3.xls-PAX2-Time_4_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104685
Benztropine (mesylate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206718
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28779
NCIH2052_PLEURA	CCLE Cell Line Proteomics	1.0	3.20021
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05629
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52718
CC2D2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675657
MCF7_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124908
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07069
Perturb_6346_KO_Raptor/Mtor_SRP402130	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.25126
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.942645
BRD-K45400577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03802
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88294
Teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157462
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35076
PMC5059470-ncomms12992-s6.xlsx-CRS-NOCRS-Supplementary_Data_5_Integration_Frequency_in_cirrhotic_CRS_and_non-cirrhotic_no-CRS_Tumor_Samples_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29Q-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DOK	GDSC Cell Line Gene Expression Profiles	1.0	2.14862
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.169616
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12018
FOSL1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63228
Perturb_2325_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.85407
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9037_KD_FOSL2_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50651
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.981885
BRD-K17339982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23473
NUFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30513
Perturb_3866_KD_MEF2D_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.64626
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18796
H3K36me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K32272500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17051
Perturb_7159_KD_ACTG1_SRP385887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.29113
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25779
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_14320_KD_CD95L_SRP111532	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.07621
STAT3-18555785-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152834
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170293
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40636
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87126
reticular formation of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01359
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60211
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0842
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.18178
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01614
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10224
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60306319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04995
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24109
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12678
Perturb_2716_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.02014
REH	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49485
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
MFSD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79961
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2353
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26012
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.68355
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nfat	GeneRIF Biological Term Annotations	1.0	null
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPD - Chronic obstructive pulmonary disease_Lung Tissue_GSE1650	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.14062
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01089
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193685_2_v_3_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172144
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-548x	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC12784616-12711_2025_1028_MOESM2_ESM.xlsx-TableS5-Table_S5_Summary_of_significant_MR_associations_in_blood_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989205
stimuli	GeneRIF Biological Term Annotations	1.0	null
Perturb_9328_OE_PIK3CA_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.85777
THOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72321
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Supratrigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04425
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07137
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-U4B1-0826-SM-4DXTW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91034
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.864844
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46637
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11205
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7155_KD_ARID1A_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.12259
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38952
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71696
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38791044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02119
Perturb_3104_KO_Nudt14_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.47578
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.12381
Perturb_17338_KO_Mageb4_SRP259999	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.19956
7473_RPL41_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612395
Perturb_8885_KD_FOXM1_ERP109084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.49772
SNX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12273
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15842
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203369
Lung squamous cell carcinoma_LUSC_TCGA-77-7140-01A-41R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20061970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74184
PMC3500769-srep00875-s3.xls-PAX2-Time_1_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
RH28	DepMap CRISPR Gene Dependency	1.0	2.80316
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38755
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.92482
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2323
KMH2	CCLE Cell Line Gene CNV Profiles	1.0	2.02788
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128671
Pretectal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03441
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-11A-01R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
P-loop containing nucleoside triphosphate hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565232
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D2-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198165,GSE198166_7_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.61932
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16331
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47927
GTEX-T8EM-1226-SM-4DM5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10301
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8213-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.95096
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353271
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.034459
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Manchette	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
Perturb_9841_KD_KDM6A_SRP254623	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.3484
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157555,GSE157556_5_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128251
r7 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14331
OE33	GDSC Cell Line Gene Expression Profiles	1.0	2.89374
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PDSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669656
Perturb_12031_KD_EFEMP1_SRP213615	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73753
UM-UC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881216
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.37958
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70002
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38055
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04474
Striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02863
GATA4-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.982643
Perturb_2416_KD_MIR193BHG_SRP268862	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73643
T24	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.32518
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857549
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
343_ANKRD52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577353
Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Lenalidomide (hemihydrate)_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165133
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7863_KD_METTL3_SRP226173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.22323
Perturb_6481_KD_SERBP1_ERP118886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.29791
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	135.833
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130843
GTEX-U3ZH-2026-SM-3DB78	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987001
Perturb_13009_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.06016
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141534
Perturb_4718_KO_Hnrnpu/Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
NANOG	ENCODE Transcription Factor Targets	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06025
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17619_KO_MLLT6_SRP245883	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2429	DepMap CRISPR Gene Dependency	1.0	3.75423
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.1166
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.07054
BRD-K87500884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49612
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170865
an3ca	HPA Cell Line Gene Expression Profiles	1.0	0.959358
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.78
OE33	CCLE Cell Line Gene Expression Profiles	1.0	2.2563
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195632
Liver hepatocellular carcinoma_LIHC_TCGA-2V-A95S-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11716_KD_GATAD2A_SRP194625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1434
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960923
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NFK9-1126-SM-3LK78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08165
OV90_OVARY	CCLE Cell Line Proteomics	1.0	2.55013
BRD-K01667746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78627
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.579281
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2885
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889161
km3	HPA Cell Line Gene Expression Profiles	-1.0	-0.992124
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33979
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WM88	DepMap CRISPR Gene Dependency	1.0	5.50276
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-18.0691
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	2.4979
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06023
STAT3	ChEA Transcription Factor Targets	1.0	null
TDRD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11477
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94561
periventricular stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13848
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06563
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9212
ChIP_TCF3_18467660	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2206
NDUFAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3419
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.17753
BRD-K21652416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85682
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.876965
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.882082
ABHD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94672
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931058
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Poisoning	CTD Gene-Disease Associations	1.0	1.17235
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041233
BRD-K47001624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40631
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lymphoblastic	GeneRIF Biological Term Annotations	1.0	null
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Raji	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71558
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NHEK	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.05647
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358662
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.830247
Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61905
BRD-K87865520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01446
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047771
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17465
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22745
rna splicing, via transesterification reactions with bulged adenosine as nucleophile	GO Biological Process Annotations 2015	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35828
Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82658
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43186
MHHCALL4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25412
Perturb_3637_KO_BLVRB_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.0212
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.5498
GSE178560_0_v_1_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brimonidine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180626
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28395
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46038
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26409
GTEX-PWCY-0926-SM-48TD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976583
Auranofin_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0320246
BRD-K80150641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25096
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135617
dorsomedial tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1106
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EN-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12572_KD_MSI1_ERP124202	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.5855
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040531
BRD-A52377240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47757
FTI-277	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08904
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.0407
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02061
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040505
PMC8185471-mmc4.xlsx-hESC-DEGs_between_SOX15_KO_hESCs_and_WT_hESCs_cells_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GR-ST	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70683
SW948	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68317
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8138
GTEX-QDVJ-1426-SM-48U1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63073
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879434
GATA2	ChEA Transcription Factor Targets	1.0	null
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.983719
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48233
TCF12_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
subthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2027
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0352
NCIH1651	CCLE Cell Line Gene CNV Profiles	-1.0	-2.55868
Perturb_825_KD_REST_SRP093671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.4299
ALL-PO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80983
BRD-K25710391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54557
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02593
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.88824
GSE224004,GSE224005_0_v_6_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LOUCY	GDSC Cell Line Gene Expression Profiles	-1.0	-2.61663
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
MOLP8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7718
CNIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05472
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39633
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.58282
FE-61-DL94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247225
OVK-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054867
Perturb_6435_KD_HOXA10AS_ERP131886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.4854
Autonomic nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
ARL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79443
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67215
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76472
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K49313348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82728
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
poly(a) rna binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1824
Sunitinib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.011437
7785_SEPTIN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745375
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.914412
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925558
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15361
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.913812
Perturb_4326_KO_Zcchc8_SRP187429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.32833
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33973
BRD-K93219845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20025
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-2026-SM-2XCB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16319
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00746185
FAM110A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26368
GTEX-QDVN-0426-SM-48TZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03816
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCABER	DepMap CRISPR Gene Dependency	1.0	2.54941
Perturb_3121_KO_Slc45a3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.86703
GSE202434,GSE202438_2_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_10282_KO_Phpt1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.7077
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.3653
Perturb_11757_KD_Gatm_SRP330646	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.87252
LOUCY	CCLE Cell Line Gene Expression Profiles	-1.0	-2.31945
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
studies	GeneRIF Biological Term Annotations	1.0	null
corticoid layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35014
Perturb_7381_KO|KD_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
FOSL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199687
Rectum adenocarcinoma_READ_TCGA-EI-6882-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cystic Fibrosis_Lung_GSE3100	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.36874
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49357
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3667_KO_FASTKD_SRP277516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.065
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44356
Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07623
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02176
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10971
FOSL1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K75717096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50928
Acute Myeloid Leukemia_LAML_TCGA-AB-2833-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
JUN_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9009_KD_RELA_SRP061289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.84009
BRD-K59957369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04668
Perturb_9354_OE_PIK3CA_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.18241
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179998
colorectal	GeneRIF Biological Term Annotations	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47517065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38178
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160466
atpase activity, coupled	GO Molecular Function Annotations 2015	1.0	null
nucleus incertus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.69859
r8 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13795
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.949924
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09092
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903371
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05646
BRD-K56761719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66325
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
striatal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20909
spleen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.21883
BRD-K12441550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66216
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35432283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43658
RL952	CCLE Cell Line Gene Expression Profiles	1.0	1.43712
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909108
LUC7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26933
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90399
K562_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197031
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colonrectum_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.16408
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18298
Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
POU5F1-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10304
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40822
AMO1	DepMap CRISPR Gene Dependency	1.0	2.60707
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.7808
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61843
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997875
abamectin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20643
superficial stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16544
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55176
Perturb_8840_KO_AKIRIN2_SRP281428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.32614
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MG-63	COSMIC Cell Line Gene Mutation Profiles	1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.52028
A704	GDSC Cell Line Gene Expression Profiles	1.0	1.76145
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32328
ALLSIL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88573
HOXB7-26014856-BT474-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4249-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306238
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62271
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GSE103297_1_v_0_glis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.699444
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173483
CRCGN011_HEPG2_24H:I09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4711
Perturb_10112_KD_FXR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.56304
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24984
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADP	HMDB Metabolites of Enzymes	1.0	null
EI24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6335
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52363
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.68326
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873138
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.992371
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19735
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906911
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27961
PMC7887593-ADVS-8-2003526-s002.xlsx-TT_AR_vs_BR-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875848
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949594
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132016
NCI-H1437	GDSC Cell Line Gene Expression Profiles	1.0	1.50593
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181926
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06399
KARPAS299	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37375
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.307832
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55619
BRD-K14266419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95095
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15849
Perturb_8920_KD_P300_SRP256204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.63698
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-1226-SM-4AT5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22753
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	3.61933
fragment	GeneRIF Biological Term Annotations	1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.135
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1224
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45115014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62147
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.93292
Perturb_12379_KO_SMARCA4_SRP324802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79071
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015838
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWCY-1726-SM-48TD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835424
Hypoglossal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0941
BRD-K83115435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06058
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.938413
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159674
HAL-01	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35866
Perturb_2696_KO_SET1B_SRP089784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.32345
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.963783
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838727
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63641
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14331
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.86609
GTEX-T6MO-1226-SM-4DM5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25934
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13998_OE_MIR1271_SRP256886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.52906
NELFE	ENCODE Transcription Factor Targets	1.0	null
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19708
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829244
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.940471
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23354
UBE2W	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29174
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12281
SMAD2-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54621976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1015
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6187
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
Perturb_11692_KD|OE_SF3A3|MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CCRF-CEM	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61489
GSE152032_3_v_2_s1pr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.860691
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0712
Beare-Stevenson cutis gyrata syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
Leading edge membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
MOLT4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6036
BRD-K72219469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06663
Perturb_3386_KO_Irf4_SRP112534	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.08906
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54534
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01058
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-CRX_DN_V1_DN-Ensemble_gene_ID_CRX	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82087
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89715
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44778
H3K36me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86242
POLR2A	ENCODE Transcription Factor Targets	1.0	null
atpase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955185
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOSL2	ENCODE Transcription Factor Targets	1.0	null
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11068
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37512
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56233
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212752
BRD-K55841827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86512
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5151-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977223
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4169-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ribonucleoprotein complex	GO Cellular Component Annotations 2015	1.0	null
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19281
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.602207
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12916
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17771
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.347
Prostate adenocarcinoma_PRAD_TCGA-J4-A83M-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17465
NCI-H1581	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8186-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08932
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KB-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.12649
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31899
CRCGN016_MCF10A.TP53.M_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07839
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7425-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
huh-7	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.0001
KNS81	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33049
Adrenocortical carcinoma_ACC_TCGA-OR-A5JM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	3.04189
GTEX-RM2N-0826-SM-48FD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39752
EIF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19792
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHAGO-K-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.11998
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4645
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28508
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.889744
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Mocetinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159891
RNA binding	GO Molecular Function Annotations 2023	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.917286
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15943
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.60079
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF3-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187445
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18422
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0472
Striatum dorsal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3221
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08599
BRD-K97921950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08048
Perturb_15146_KD_CUX1_SRP343012	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.05587
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-71-YF45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289632
hsa-miR-4800-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964618
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-1726-SM-4E3IF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905167
Exudative vitreoretinopathy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9831
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922189
DLST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29282
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68933
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.61769
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Helicase superfamily 1/2, ATP-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3644_KO_EIF2AK3_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.70746
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164017
Perturb_738_KD_MBNL1_SRP139891	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.78453
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16372
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15037
GTEX-WFON-0826-SM-4LVMI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08334
A549_Belinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00930073
A549_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156729
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4343
GTEX-QDVN-1226-SM-48TZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829925
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82493
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79437066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64921
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	182.869
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151266
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.991295
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136747
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95674
Perturb_12722_KD_KMT2C_SRP110043	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.62876
Perturb_10310_KO_3110043O21Rik_ERP013119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.57678
Sarcoma_SARC_TCGA-DX-A8BT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77472
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31541
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71499
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829904
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12569
BRD-K85908443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.59501
Perturb_1094_KO_ATXN1L_SRP230198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.8671
BRD-K70648728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11683
BRD-K35727710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35911
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2323_KD_RBMX_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87213
BRD-K44401329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21883
BRD-K85044233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38793
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147044
UMUC9	DepMap CRISPR Gene Dependency	1.0	5.52243
ISLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17251
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934937
Perturb_14903_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.05959
Perturb_7384_KO|KD_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SOX2	ChEA Transcription Factor Targets	1.0	null
FOXB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5145
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050436
Perturb_4720_KD_Tp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
NCIH226	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34003
Weight Loss	CTD Gene-Disease Associations	1.0	1.06625
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thymic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14659
BRD-K79529972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42551
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E7-01A-31R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3913-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-SJXC-0126-SM-2XCFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14708
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1489
Perturb_12935_KD_CDK9_SRP340404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.35834
Perturb_9084_KO_NSUN2_SRP400807	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.85936
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-WW-A8ZI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18535662-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
SALL4-18804426-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08122
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38776
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.773501
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE244072_4_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Balsalazide (sodium hydrate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132785
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30844
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
K5	GDSC Cell Line Gene Expression Profiles	1.0	1.51858
BRD-K95941120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27412
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13873_KD_ELF4_SRP182698	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.97059
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.95955
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_PRDM14_20953172	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
A549_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188651
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132444
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04017
WSB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18401
ChIP_SALL4_18804426	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877693
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40947
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12648
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86409
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73971
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S3XE-1026-SM-4AD4O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9803
MCF7_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316475
GTEx SalivaryGland 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-3.72295
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923734
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856522
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49851
BRD-K04363234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90571
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.295
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2426
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061373
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73591
pterigoid muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3201
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
OTS514_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0225425
superficial stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16864
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19347
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20765
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hsa-miR-4764-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015118
FGFR3_knockdown_34_GDS4454	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.08208
Perturb_3875_KD_PLK4_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.52958
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06619
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192673
A549_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175811
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363679
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.4903
rectum_8d	HPA Tissue Sample Gene Expression Profiles	1.0	1.25411
BRD-K80945184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23022
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977187
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24112
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24798
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01531
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M9-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14207
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	2.37158
BRD-K66641352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13965
SAAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29006
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216667
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU5F1	ChEA Transcription Factor Targets	1.0	null
GTEX-REY6-1326-SM-48FDO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874777
organelle part	GO Cellular Component Annotations 2015	1.0	null
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.2736
Perturb_7494_KD_DICER1_SRP186271	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.68241
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73039
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5384
dorsal part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22476
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7328_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2082
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843053
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847406
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158408
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.962067
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3130-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Perturb_2319_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.45351
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22103
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16566
Perturb_14889_KO_H14_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.85704
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60726
Perturb_17620_KO_MLLT6_SRP245883	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.8153
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0178066
AZD2858_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0227637
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141007
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42561
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-4745-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_24Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.7313
BRD-K85007671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17517
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12567
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145064
stomach	HPA Tissue Gene Expression Profiles	1.0	0.838854
GTEx Muscle 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-9.3869
Perturb_11788_KO_Ccl8_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45436
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inner SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943386
BTAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02778
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.04094
MYOG	ENCODE Transcription Factor Targets	1.0	null
4158_IP6K1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533563
cellular process	GO Biological Process Annotations 2015	1.0	null
Sympathetic chain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.963
polymorph layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08226
JURKAT	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.3495
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14331
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.697808
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23161
increased body weight	GWASdb SNP-Phenotype Associations	1.0	0.701431
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	1.0	null
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_7158_KD_circFAM120A_SRP259913	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.39694
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.18356
BRD-K40776502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36875
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33061098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7851
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.1582
Squamous cell carcinoma of mouth_Oropharynx Epithelium_GSE3524	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.65355
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08941
Perturb_3072_KO_Caskin2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.46002
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39675
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61605
KIF3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448635
EB2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78516
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.896017
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837141
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900389
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5961
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77472
Rdw - Red Blood Cell Distribution Width Result	DisGeNET Gene-Phenotype Associations	1.0	null
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MOLM6	CCLE Cell Line Gene CNV Profiles	1.0	1.3942
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10109
Perturb_8924_KD_LINC01133a_SRP320645	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.57676
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.06393
periventricular stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66823
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018144
BRD-K39013648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01464
11142_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534754
Perturb_2906_OE_MACROH2A2_SRP333362	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.18912
Finasteride_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237794
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23541
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12386
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915379
MTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60048
BPH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
IFITM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22802
Perturb_3065_KO_Abca8b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.71116
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160995
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59658
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VM-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.69898
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1439
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017586
mrna metabolic process	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97839095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03193
Acute Myeloid Leukemia_LAML_TCGA-AB-2915-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308325
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142001
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.51843
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42523
Perturb_7298_KD_PCIF1_SRP162223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.76857
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.63722
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02397
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613144
lateral medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23425
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKN74	CCLE Cell Line Gene CNV Profiles	1.0	1.34322
Perturb_10852_KO_Smyd3_SRP057101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.29173
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9341_OE_PIK3CA_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.28736
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87015
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67709
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20029
Perturb_9351_OE_HCRED_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87934
BRD-A89554862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.19671
Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE133516_5_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Adult Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
Perturb_9325_OE_HCRED_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04169
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFON-1126-SM-4LVMA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86894
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CBX3_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977397
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02456
intermediate stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35014
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_6_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28048
Perturb_14737_OE_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.06193
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63954
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_3093_KO_H1foo_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.19664
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964754
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7925689-41467_2021_21687_MOESM10_ESM.xlsx-A_HIF1A-Unnamed_8_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_8_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214077
Oligospermia	CTD Gene-Disease Associations	1.0	1.10104
H6PD_KO_GDS3195_603_mouse_Skeletal muscle - Tibialis anterior	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.112
nuclear part	GO Cellular Component Annotations 2015	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
Minodronic acid_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0105411
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1913
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3865_KD_ITPR3_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.8595
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35049
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192873
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.882878
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41882
RPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15284
MUTZ5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70437
BRD-K67336565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21754
GTEX-QV31-0626-SM-447C5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58878
KINGS1	DepMap CRISPR Gene Dependency	1.0	3.08711
NCI-H1781	COSMIC Cell Line Gene CNV Profiles	1.0	2.14116
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30859
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03551
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899417
CRCGN017_MCF10A.TP53.M_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1078
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.170789
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68085
hsa-miR-3942-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.915173
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.039308
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48908
Perturb_6711_KD_STAU1_SRP266909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.71088
periventricular stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36687
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137318
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Glaucoma_Retina_GSE3554	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.81748
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21133
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6605
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06999
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69113
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0287505
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979539
TCF3/E2A-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_17765_KO_Prdm16_SRP238935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.63768
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_547_KO_SA1_SRP201842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.42263
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U4-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4316_KO_Ror2_SRP292420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.037
protein binding	GO Molecular Function Annotations 2015	1.0	null
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75756
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.74368
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02039
CTBP1-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.42321
Acute Myeloid Leukemia_LAML_TCGA-AB-2963-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171971
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.082
colon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38901
GSE242083,GSE242098_3_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13562
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23021
Fatty Liver	CTD Gene-Disease Associations	1.0	1.39535
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_15457_KO_GPRC5A_SRP165862	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.88779
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13087600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19352
Ramos-2G6-4C10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58713
Brain Lower Grade Glioma_LGG_TCGA-DU-6394-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6953-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11809_KO_Klf14_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.14123
Perturb_14662_KO_Ogt_SRP198294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.00847
Perturb_3749_KD_NORAD_SRP149071	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.11338
Perturb_9290_OE_KRAS_SRP172671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62585
Colonic epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
BRD-K62714735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85545
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17144
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92952
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234987
Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q9-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Perturb_3393_KO_Cblb_SRP347245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.46523
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3133	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
RPS6KA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515446
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186201
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6825-01A-21R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15213_KD_BRD4_SRP255722	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.3341
Perturb_4719_KO_Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K64976146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18445
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K26237438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87309
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PXYLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55586
6446_PLEKHJ1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.730727
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GSE249544,GSE249637_9_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
LINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10411
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1396
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3R1-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16711_KO_Phtf1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.83103
Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0153
SKNMC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49221
Sarcoma_SARC_TCGA-DX-A7EF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80858297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33982
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21125
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
GSE148692,GSE148695_2_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XA-A8JR-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
REST-18959480-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
UOK101	CCLE Cell Line Gene CNV Profiles	1.0	1.43877
J82	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Superior central nucleus raphe, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08143
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896684
GSE140965_2_v_3_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22103
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06563
Perturb_3253_KD_RPS19_SRP092068	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.52298
Perturb_3862_KD_GPR56_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.11318
BRD-K92210988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61186
BRD-K40982265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2621
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31159
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32866
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17642_OE_YAP_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.13085
atp-dependent helicase activity	GO Molecular Function Annotations 2015	1.0	null
TAL1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K03852663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31681
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41767
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.18766
MCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.095
anterior pretectal nucleus, dorsal superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02964
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20757
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325454
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	0.908379
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PH-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196731
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293094
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23717
NCIH1573	CCLE Cell Line Gene Expression Profiles	1.0	1.98391
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU626	DepMap CRISPR Gene Dependency	1.0	5.41329
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DKMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57218
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.880422
Lipoic acid_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0256015
intracellular part	GO Cellular Component Annotations 2015	1.0	null
BRD-A93236127_DIGITOXIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_9367_OE_PIK3CA_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.08404
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84104
GSE232944_1_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.75254
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SOX11	ChEA Transcription Factor Targets	1.0	null
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11954
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.77066
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81255
PC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE130401_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21266
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5642
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05739
BRD-K31960013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59017
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KOSC-2	GDSC Cell Line Gene Expression Profiles	1.0	1.71918
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5794
Perturb_11785_KO_Btnl1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.9091
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	168.281
CAL-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987425
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07063
Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A172_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.04267
FLI1	ChEA Transcription Factor Targets	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159225
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.32651
Perturb_3877_KD_RELB_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.13502
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37548
Perturb_10099_KD_HNRNPU_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.89984
Phosphoric acid	HMDB Metabolites of Enzymes	1.0	null
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.88319
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211912
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961924
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17642
Perturb_4860_KD_BAF47_SRP188516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.33101
Adrenocortical carcinoma_ACC_TCGA-OR-A5J7-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_342_KD_GDF6_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SARS-CoV_24Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.98194
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
stomach	GTEx Tissue Gene Expression Profiles	1.0	1.05304
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63805
TC-66-CI47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24324
lymphnode_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.49748
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915499
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.970025
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.99814
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZP-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108344
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18728
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19864
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42397
JUN	ChEA Transcription Factor Targets	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61705
H4K20me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_10120_KO_RNH1_ERP021688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3052
CEBPB	ENCODE Transcription Factor Targets	1.0	null
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16903
atp-dependent rna helicase activity	GO Molecular Function Annotations 2015	1.0	null
PXMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44497
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5248-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16712_KO_Ppbp_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.08854
SUDHL10	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88366
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
putamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37022
GSE252857_2_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QCQG-0526-SM-48U2A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48723
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JURKAT	CCLE Cell Line Gene Expression Profiles	-1.0	-3.67768
mantle zone of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35053
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23610423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00569
SLC25A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48329
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20759
MYOD1	ENCODE Transcription Factor Targets	1.0	null
Perturb_6897_KO_TP53/ZNF84_ERP125489	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.14343
Perturb_4767_KO_Kap1_SRP065215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.37185
DGKK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92534
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.16182
Perturb_7379_KD_SMG5_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.65518
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927786
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
WM88_SKIN	CCLE Cell Line Proteomics	1.0	3.34647
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0166
BRD-K26130452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18456
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110485
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23604
Perturb_9353_OE_NRG1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.17149
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840712
NCOR-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162789
Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.31974
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.573577
redistribution	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-7547-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04257723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00457
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34944
hsa-miR-4326	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
SUPT1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45757
BRD-K50300854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10533
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.046988
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219884
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4827-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.9931
hsa-miR-4530	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10993
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51628
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62474
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24073
697	CCLE Cell Line Gene Expression Profiles	-1.0	-2.21296
raphe nuclei of medulla	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45211
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.997214
Perturb_2826_OE_BAD_SRP064353	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01099
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01436
GSE249544,GSE249637_9_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A561-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184081
SNU398	CCLE Cell Line Gene CNV Profiles	1.0	1.57613
Perturb_9971_KD_BCCIP_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183255
PLXNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02603
SZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.936332
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051067
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
chr10_125948937_A_G_b38	GTEx eQTL 2025	1.0	1.72746
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24635
MCF7_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165874
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4676
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146941
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.970814
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	3.39725
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825032
GTEX-PWN1-2526-SM-48TDS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987983
Perturb_17585_KO_Nubpl_ERP016523	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.5978
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88858
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SHP-77	GDSC Cell Line Gene Expression Profiles	1.0	1.66103
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
ILF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471965
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20404
GTEX-V1D1-1726-SM-4JBHB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866434
Perturb_11949_KD_NRF2_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00907
Perturb_14847_KD_PEG10_SRP055517	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.48115
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14205
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.674412
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65272
yet	GeneRIF Biological Term Annotations	1.0	null
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58635
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979694
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24235
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC12784616-12711_2025_1028_MOESM2_ESM.xlsx-TableS8-Table_S8_Summary_of_significant_MR_associations_in_liver_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201072
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15729
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132766
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32928
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245176
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146409
Perturb_9890_KD_HNRNPM_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.13064
chr10_125893653_C_T_b38	GTEx eQTL 2025	1.0	5.26702
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.15635
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10637
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998037
GTEX-SUCS-0726-SM-4DM7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03279
GTEX-VJYA-1026-SM-4KL21	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970544
BRD-K04710685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20812
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00083
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06338
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849283
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840522
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
T-lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765179
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15904
FOS_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
TSHZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03661
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
apoptotic	GeneRIF Biological Term Annotations	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59588
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7596_KO_PRPF39_SRP389969	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.14925
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2734_KD_BCKDK_SRP298085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.00063
reticular formation of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04247
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5374
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15447_KD_HDAC5_SRP273298	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.16108
Perturb_11691_OE_MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4204
Brain Lower Grade Glioma_LGG_TCGA-S9-A7QW-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161001
Perturb_2723_KD_HOTAIR_SRP172688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.58555
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16969
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.46674
pre-t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251606
GSE81193_3_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Roxadustat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146634
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36453
SLC35A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13375
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Hydroxyfasudil_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0172848
Perturb_7423_KD_DKC1_SRP045222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.41148
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924703
sw1463	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
A549_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173575
RXRA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259444
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02793
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200125
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6458_KO_MTF1_SRP212065	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.22579
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56113
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13302_KO_Tet2_SRP338315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.81448
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876139
Acute Lymphocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
Perturb_7623_KD_UPF1LL_SRP295982	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.82905
bed nucleus of the stria terminalis, laterocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15159
CHD1	ENCODE Transcription Factor Targets	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141993
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989327
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7758
BRD-K47878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33064
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6470-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.74221
leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057123
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7177-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7304_OE_SF3B1_SRP286876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.71698
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10988_KO_Gnpda2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.43904
RIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57873
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.851214
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFJO-0826-SM-4LVM5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909795
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.107588
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4076-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48994888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48411
GSK3A_KD_GDS4305_182_human_THP-1 acute myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_14853_KD_TEAD4_SRP247403	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.44909
Perturb_10001_KD_FMR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.02854
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17356
BRD-K45058329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72804
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.92021
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.32122
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_937_KD_Smndc1_SRP337256	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61717
POU5F1-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_66_OE_Zscan4_SRP252595	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.51792
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37983
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.63745
GSE148695,GSE167281_0_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
BT20	CCLE Cell Line Gene CNV Profiles	-1.0	-2.10846
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79661
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JUN_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140359
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151873
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0298
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34162
STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.924914
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monastrol-614	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Cervical ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08778
BCL3	ChEA Transcription Factor Targets	1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Red blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
MCAS	CCLE Cell Line Gene CNV Profiles	1.0	1.67091
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r2 part of median raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43227
BRD-K35527855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80393
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942792
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MS751	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42551
PMC12433928-12672_2025_2985_MOESM1_ESM.pdf-33-ZNF671_ZNF671	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013327
BRD-K18447546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22686
Perturb_2341_KD_BRCA2_SRP153058	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.67639
BRD-K56214240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06583
SMAD2	ChEA Transcription Factor Targets	1.0	null
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220673
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829036
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309637
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876771
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82444
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.112562
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03805
K562_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015463
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938445
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70382
Perturb_3114_KO_Rabl6_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.01033
GSE100464,GSE100465_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7161353-supp_073353.119_Supplemental_Tab_S8.xlsx-LUAD_HRGs_correlation_to_MBNL2-gene_name_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10022_KD_PSIP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94826
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09885
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29543
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32683
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133285
K562_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184527
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the coronary arteries	GWASdb SNP-Phenotype Associations	1.0	0.296587
atp binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996572
TCF3-18467660-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17959
A549_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167781
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3431
ETS1	ENCODE Transcription Factor Targets	1.0	null
different	GeneRIF Biological Term Annotations	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10994
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78978845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10631
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.06225
Perturb_15178_KD_NR037661_SRP394097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.7454
dysregulated	GeneRIF Biological Term Annotations	1.0	null
Perturb_14589_KI_LAMC2_ERP136718	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.78381
Obesity_Adipose tissue_GSE4692	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.84543
CCDC86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22626
Anterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23125
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.773501
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00952
BRD-K49635910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23058
Generalized dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TIMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07816
SF539	DepMap CRISPR Gene Dependency	1.0	2.90092
BRD-K21180458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08388
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.874367
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0598
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23604
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825435
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877174
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49445
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.49542
Inflammation	CTD Gene-Disease Associations	1.0	1.19835
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04293
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10153
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145434
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85502
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_8928_KD_CHD4_SRP350011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.30186
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16365
HCC1395	DepMap CRISPR Gene Dependency	1.0	2.1699
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	2.41276
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00094
K562_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192581
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
MCF7_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148456
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.281821
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01492
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02263
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5089
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322495
transcription	GeneRIF Biological Term Annotations	1.0	null
BRD-K94317551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01425
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10275
Lung adenocarcinoma_LUAD_TCGA-78-7146-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.45383
GSE228106_0_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Canagliflozin (hemihydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0119628
MCF7_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119759
Perturb_2666_KD_JUN_SRP357624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.62938
liminal part of the r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35008
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29246
LY411575	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
CHLA57	DepMap CRISPR Gene Dependency	1.0	2.30113
regulating	GeneRIF Biological Term Annotations	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71956
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Cloxacillin (sodium)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.035135
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23582
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143882
involvement	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961172
GTEX-S7SF-1426-SM-4AT5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10071
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.484
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23319
hsa-miR-4328	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168956
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.01212
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55984
GSE207471_2_v_0_btla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214308
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63805
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14884_KO_H12_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.12066
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8636-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70766
salivary gland	GTEx Tissue Gene Expression Profiles	1.0	0.907374
Perturb_11511_KD_Fbxo22_SRP170074	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.22791
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Omeprazole (sodium)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0108643
mantle zone of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15159
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.150898
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Superior cervical ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3751
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VMCUB1	DepMap CRISPR Gene Dependency	1.0	4.4645
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28914
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267889
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859863
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WXYG-2026-SM-4E3IY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03904
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07857
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.00592
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25247
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167082
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic	GeneRIF Biological Term Annotations	1.0	null
BRD-K01142063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10583
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85757
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55076
GTEX-OHPK-1526-SM-3MJGM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25738
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91866516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16218
KLF4	ChEA Transcription Factor Targets	1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52974
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65E-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49999779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26301
peripheral	GeneRIF Biological Term Annotations	1.0	null
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.31762
USF1	ENCODE Transcription Factor Targets	1.0	null
Liver cancer stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A856-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2119_DDX3X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.816509
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14367
Perturb_18496_KD_LINC00881_SRP362016	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.06856
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00855
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_14118_KD_RPS6KB2_SRP187713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.30999
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21077
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71665
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90317
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00039
BRD-K93800933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13979
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.904303
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
rna splicing	GO Biological Process Annotations 2015	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.786079
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191453
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-0826-SM-447B3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0751
Gefitinib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0252151
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE86507,GSE86509_7_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198223
caudal putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.0348
ROCK1_knockdown_156_GSE34769	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.3505
BRD-K50201262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21059
BRD-K88996418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24877
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03497
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.91
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262519
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01915
BABAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44636
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30832
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24146
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7855_KD_E2F7/E2F8_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.84163
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907319
Perturb_3622_KO_SMARCC2_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.24852
Perturb_14605_KD_NUSAP1_SRP407652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.46196
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09402
Perturb_7177_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76458
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134491
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus of the optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36738
periventricular stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14167
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137931
GTEX-PWCY-0726-SM-48TCS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04785
Perturb_7502_KD_PHF12_SRP194754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.21671
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung adenocarcinoma_LUAD_TCGA-MP-A5C7-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFPAC1_PANCREAS	CCLE Cell Line Proteomics	1.0	2.09117
Perturb_14339_KD_CTCFL_SRP306444	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.8921
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845491
Perturb_14515_KO_Esrrg_SRP331239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.78485
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0065
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.686
BRD-K16791544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.62493
MEC1	DepMap CRISPR Gene Dependency	1.0	4.02272
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.003
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88163
hsa-miR-4789-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
containing	GeneRIF Biological Term Annotations	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.43412
CRCGN009_HEPG2_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10662
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53904
BRD-K61485947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11624
SP1	ENCODE Transcription Factor Targets	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.75679
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207421
intermedioposterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09908
Perturb_163_KD_RAC1_SRP387923	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.048
r2 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04979
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992793
Prostate adenocarcinoma_PRAD_TCGA-HC-7075-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
3639_HAUS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563852
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846236
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
hsa-miR-140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
MCF7_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180662
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48579
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8047323-Table_3.xlsx-Venn_581_LPS_T24_vs_LPS_T0-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.23074
RS11846	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.922214
Perturb_7900_KO_FOXM1_SRP345649	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.61623
BRD-K33951208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12575
TP63	ChEA Transcription Factor Targets	1.0	null
2907_FAM216A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513304
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04054
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CEBPB_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75337
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2326_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.43034
MPDZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17316
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26577
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64708
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02378
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10863
VSIG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463549
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.761718
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K19645475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63897
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30058
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.939559
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47861
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95751
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSF1_01_178	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.00194
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32717
BRD-K06577881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33507
BRD-K78249980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04079
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.003
PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154496
RUNX1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S4Z8-0126-SM-4GICC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916208
BRD-K84935903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39624
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255062
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rectum_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.70772
Perturb_9785_KD_EPS15_SRP339484	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.63448
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Table_S6_Overlap_of_differentially_expressed_genes_in_Tg_HSP_EWS-FLI1_embryos_and_human_EWS-FLI1_signature_from_Smith_et_al_2006_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04217
PMC3500769-srep00875-s3.xls-PAX2-Time_24_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4418-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209927
Perturb_7950_KO_BAZ1A_SRP100570	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.62122
hsa-miR-548ae	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2913
4star	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.11657
Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2122	COSMIC Cell Line Gene Mutation Profiles	1.0	null
helicase	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3500769-srep00875-s3.xls-CEBP-Time_24_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.009672
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87663
BRD-K82784817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96118
POLR1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2518
downregulated	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-593	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
SMAD3-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
pyrophosphatase activity	GO Molecular Function Annotations 2015	1.0	null
A549_Barasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192907
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17317
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29954
SNUC4	DepMap CRISPR Gene Dependency	1.0	2.09731
BRD-K21193980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30665
Perturb_10651_KD_Syncrip_SRP065017	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6764
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.46681
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148200_1_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3500769-srep00875-s3.xls-GATA3-Time_24_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	2.54425
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49117
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02201
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217156
proximal	GeneRIF Biological Term Annotations	1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71944426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29821
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176663
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140815
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.908
Perturb_11835_KO_Scarf2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.14974
Perturb_7965_OE_MPL_SRP287959	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.13799
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02674
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
t-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315135
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015029
Lung squamous cell carcinoma_LUSC_TCGA-85-8584-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7854_KD_CCNF/E2F7/E2F8_SRP212181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.9376
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01221
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29383520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5151
HCT-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
LU99	CCLE Cell Line Gene CNV Profiles	1.0	2.19276
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.02601
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.86526
Perturb_7367_KD_H2BC21_SRP308810	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.31063
Perturb_9324_OE_FGFR1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.70209
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310574
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3009-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177778
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012912
WARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31016
TEAD4_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tirabrutinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321739
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.918544
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
andor	GeneRIF Biological Term Annotations	1.0	null
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015897
RXRA	ENCODE Transcription Factor Targets	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989529
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.695
Fostamatinib (disodium hexahydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249161
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161942
r8 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48866
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184874
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03223
BRD-K61555339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16086
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0486
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1541
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18331
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.71372
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Clathrin coat of coated pit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889391
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76351
peripheral blood mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186943
SNU1033	DepMap CRISPR Gene Dependency	1.0	3.08777
BRD-K84792324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51932
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36454
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843648
dexamethasone_rattus norvegicus_gpl1355_gse29912	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.82438
U251	GDSC Cell Line Gene Expression Profiles	1.0	1.43811
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	2.1959
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163809
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7805
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1928
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28513
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40446
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_EED226_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0108317
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0473
NCI-H2227	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.2703
GSE86507,GSE86509_3_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214867
jurkat cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.448731
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173748
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.057237
GTEX-XQ8I-2026-SM-4BOOL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15464
Perturb_6857_KD_CNOT7/CNOT8_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.96262
TCF3-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11567
BRD-A85028244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73272
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280025
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35783
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6869_PSMD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12403
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00773
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K35792251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49239
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115652
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAPLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0361
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-0126-SM-4DXSN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845697
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00757
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828915
Perturb_9093_KD_SMARCA4_SRP293297	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.656
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40226
largeintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.06126
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.168854
Acute Myeloid Leukemia_LAML_TCGA-AB-2890-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179868
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2253
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.80711
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151482
PMC7161353-supp_073353.119_Supplemental_Tab_S8.xlsx-BRCA_HRGs_correlation_to_MBNL2-gene_name_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05891
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132421
HERC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2938
BRD-A77181042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08086
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67399222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51299
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2145
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.918177
Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265819
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24993
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9364_OE_HCRED_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.1734
AP-2 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90089
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE254526,GSE254528_0_v_1_phf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303294
sites	GeneRIF Biological Term Annotations	1.0	null
CFPAC1	CCLE Cell Line Gene Expression Profiles	1.0	1.56953
MUTYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11968
GSE184902_3_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.6493
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054738
Larotrectinib sulfate_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262679
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rna splicing, via transesterification reactions	GO Biological Process Annotations 2015	1.0	null
Perturb_11867_KO_1810027O10Rik_ERP013119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.52077
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.887728
oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.067893
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937294
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.234827
Perturb_13921_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.44102
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826257
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146917
Perturb_3651_KO_RIPK1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.70635
Nucleus of the solitary tract, commissural part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81511
JUND_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184902_3_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.05335
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959511
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleoside-triphosphatase activity	GO Molecular Function Annotations 2015	1.0	null
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0307699
CAL-78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870616
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963414
Tranilast_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0109298
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-63-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965287
mrna processing	GO Biological Process Annotations 2015	1.0	null
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865945
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.953341
TCF3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6434_KD_HOXA10AS_ERP131886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.83225
GTEX-S4Q7-0626-SM-4AD5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35975
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153708
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505286
teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K26708780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1704
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.52544
Perturb_9407_KD_GATA6AS_SRP279802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.74418
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.905959
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.967321
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GGTLC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01056
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.07556
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64704925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23441
GSE174383_2_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AMO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67071
zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.595853
Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42084
Perturb_11789_KO_Ccl9_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.34128
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43815
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12947
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150056
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100609_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11763
Exodeoxyribonuclease V complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.546
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012921
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO Molecular Function Annotations 2015	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77795_0_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tetracycline (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0143637
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4176
SLC18A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477306
Perturb_10874_OE_LIPA_SRP328944	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.51376
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r10 part of vagal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.36818
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282303
CEBPB_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848391
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116672
Perturb_7160_KD_ACTG1_SRP385887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.47219
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45O-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39227064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68591
ChIP_PRDM14_21183938	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_3712_KO_PIWIL1_SRP188921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.76655
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0226-SM-4DM6V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829789
Perturb_12945_KD_METTL3_SRP106608	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.46404
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01867
SP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824121
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SP-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K47314501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34231
Perturb_9339_OE_NRF2_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.94576
acute myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101708
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 pontine raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02332
Perturb_11780_KO_Apof_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.88595
Subthalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10848
Lung squamous cell carcinoma_LUSC_TCGA-34-5241-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51297
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BE-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K41355839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02097
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55333
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Red Cell Distribution Width Determination	DisGeNET Gene-Phenotype Associations	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.884702
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.891511
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857696
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152734
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3500769-srep00875-s3.xls-GATA3-Time_1_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF326	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09259
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.08701
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12951_KD_ALKBH5_SRP247667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.13886
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56254
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24978
USP47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62424
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161827_2_v_3_ertugliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RBM39_02_151	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60039
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19103
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FOSL2_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1436	CCLE Cell Line Gene CNV Profiles	1.0	1.59835
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841741
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38038
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82579
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11446
BRD-K17482962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00449
Mean corpuscular hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.50458
GTEX-SE5C-1126-SM-4BRWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1558
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K38558166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13113
ventral striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16418
Perturb_7382_KO|KD_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20928
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
P12-ICHIKAWA	GDSC Cell Line Gene Expression Profiles	-1.0	-1.81475
KNS42	DepMap CRISPR Gene Dependency	1.0	2.20442
LIVF001-008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05442
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09199
KARPAS422	DepMap CRISPR Gene Dependency	1.0	4.09979
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179538
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.872414
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160579
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0467
SMAD1-26771354-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
GSE149075_6_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
outer SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976472
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62444
MOLT4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.83421
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_28_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
KMS21BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90677
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1481
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267655
mitochondrial	GeneRIF Biological Term Annotations	1.0	null
rna helicase activity	GO Molecular Function Annotations 2015	1.0	null
957_C11ORF74_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597944
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050254
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24445
GOTO	GDSC Cell Line Gene Expression Profiles	-1.0	-2.10184
rna	GeneRIF Biological Term Annotations	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12433
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.342777
MCF7_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030727
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.831349
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10080_KD_IGF2BP3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76311
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13415
ZFX	ChEA Transcription Factor Targets	1.0	null
ZNF771	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33431
TE-16-VT54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204154
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30441
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21000135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41665
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1278
CB-44-RT90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208022
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1495
Perturb_10962_KO_Arl10_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6233
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244027
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042463
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864197
Carbidopa (monohydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0406884
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21326
SP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.900141
BRD-K63806140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15975
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.863068
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11442
ATF3	ENCODE Transcription Factor Targets	1.0	null
Perturb_5261_KO|KD_Mir290a/Mir290b/Mir291a/Mir292/Mir292/Mir291b/Mir293/Mir294/Mir295|Tfap4_SRP326984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.07086
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199949
Nucleus accumbens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21954
characterization	GeneRIF Biological Term Annotations	1.0	null
CRCGN008_HEPG2_24H:J14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02325
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48805
BT474	CCLE Cell Line Gene CNV Profiles	-1.0	-2.33583
SSB_02_107	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59352
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45005
Helicase-associated domain	InterPro Predicted Protein Domain Annotations	1.0	null
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94331
BW-B70C-1132	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35335
striatum (corpus striatum)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29019
Perturb_9327_OE_NRG1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.74776
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02934
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884078
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.854136
DDX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84613
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26264
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K82823857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94125
PMC9691391-7945884.f3.pdf-214-ENSG00000183621_ZNF438	Rummagene Transcription Factor Associations 2026	1.0	null
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.6077
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212697
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Erythromycin_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271368
ventral claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845872
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17440_Mut_Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.03387
Perturb_398_KD_WTAP_SRP039397	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.22532
PMC3500769-srep00875-s3.xls-CEBP-Time_0_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59514
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A538-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_15777_KO_Nmnat1_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.88137
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4083
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03663
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.933316
Perturb_3514_KD_RNPS1_ERP130704	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.54698
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.125
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0684
Perturb_11891_KO_Arg2_SRP198795	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.75926
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37493
Perturb_15463_OE_BHLHE22_SRP380212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.85868
Perturb_12046_KO_Eed_SRP327420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.7719
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29799
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.956843
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09651
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9994
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38595
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10005_KD_METAP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.85952
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205302
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966365
4EGI-1_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0327743
Perturb_4714_KO_Hnrnpu/Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-XAJ8-0826-SM-47JY6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45372
FOXA2	ChEA Transcription Factor Targets	1.0	null
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.984351
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58288
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Perturb_9999_KD_BOP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.57933
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_282_KD_IMPDH1_SRP251285	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.699
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00207
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.131248
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33472
SNUC2A	CCLE Cell Line Gene Expression Profiles	1.0	1.51206
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29023
PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_24_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83189379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30053
Perturb_9326_OE_NRF2_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.6311
GTEX-T6MO-0526-SM-4DM6R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973768
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.874102
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6082
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Main olfactory bulb, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21822
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15460_KD_CSN5_SRP316687	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.90229
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00528
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02977
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14286
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
Clotrimazole_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0190785
colonrectum_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.21166
MCF7_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190915
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-5.25078
MCF7_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015454
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_8919_KD_ARID1A/P300_SRP256204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.02156
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46301
CTV1DM	DepMap CRISPR Gene Dependency	1.0	7.47618
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.907542
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85776
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.83047
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01139
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30433
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9340_OE_NRG1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.83684
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311819
GTEX-XQ3S-0126-SM-4BOO9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895275
Perturb_11717_KD_MBD2_SRP194625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.3063
Perturb_4383_KO_PRMT5_SRP149386	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.33731
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7795
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97795
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.234827
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.908
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.35469
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.70719
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DAUDI	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47027
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0047
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_11175_KD_ZNF529_SRP201912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ANXA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66927
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.547571
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2291	CCLE Cell Line Gene Expression Profiles	1.0	1.56381
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34162
M059J	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23544
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHCHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13092
PMC5029704-oncotarget-07-24326-s006.xlsx-Sheet1-Genes_that_are_downregulated_in_low_TET1_compared_to_high_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23617
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54839019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08179
PMC8047323-Table_1.xlsx-FC_LPS_T24_Vs_LPS_T0_P_0_05_FC-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56765
BRD-K06094529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68608
Perturb_7165_KD_FTH1_SRP385887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.10974
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01842
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935641
Perturb_16303_KO_Esr1_SRP115139	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.0969
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016539
BRD-K44984558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04418
PMC4989457-13073_2016_339_MOESM9_ESM.xls-MITF_Q1_vs_Q4-Gene_id_HUGO_ID_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7103
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20367
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3ML-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01864
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.904531
GTEX-P4PP-0626-SM-3NM9X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868545
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HCV JFH-1_18Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.88843
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47052
MAPRE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06489
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12728
GRK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538825
Perturb_9816_KD_ARID5B_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.07997
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146745
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.607746
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959511
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12698
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r2 part of the trigeminal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16385
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10403
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015326
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD3	ChEA Transcription Factor Targets	1.0	null
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03944
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02934
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hMPV_24Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.81974
HCC1395	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10054
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884318
SK-MEL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164443
A549_SRT2104_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133369
SKMEL19	DepMap CRISPR Gene Dependency	1.0	6.0052
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130135
abnormality of the oral cavity	GWASdb SNP-Phenotype Associations	1.0	0.134618
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24956
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	1.42087
abnormality of the mouth	GWASdb SNP-Phenotype Associations	1.0	0.125592
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864731
Perturb_11818_KO_Nudt19_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82761
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMAD2-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4758-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016903
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.195713
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02717
Pravastatin (sodium)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244938
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872733
STAT5B-24692510-EPITHELIUM-MOUSE-MAMMARY	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-128	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3279
abnormality of taste sensation	GWASdb SNP-Phenotype Associations	1.0	0.473486
BRD-K86792405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22173
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980923
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0100102
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05412
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5871
A549_Tazemetostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139421
CRCGN015_MCF10A.WT.HP_24H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12955
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013298
15489886-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
subcuneiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22218
LYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70012
Tetracycline (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0153323
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04521490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3106
Spliceosomal tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.874
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Olanzapine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132304
MCF7_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139048
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19268781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04247
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.951
Perturb_17640_OE_WWTR1_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.9462
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.174
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05608
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_14573_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0498
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.965029
Perturb_4003_OE_HMGA2_SRP125952	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.80075
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43594798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42511
SKMEL2_SKIN	CCLE Cell Line Proteomics	1.0	3.02097
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZH-1326-SM-3NB1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03444
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99039
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50763
PTGER2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650857
Perturb_4717_KO_Hnrnpu/Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05585
Perturb_3573_KD_JAB1_SRP222371	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
AD-43-EQ11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271341
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152967
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
MDAMB415	CCLE Cell Line Gene CNV Profiles	1.0	1.92066
PELI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21991
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.971027
OCIP5X	DepMap CRISPR Gene Dependency	1.0	2.36084
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.947666
MCF7_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013928
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1619
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44566
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48875630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03616
IFNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590417
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178277
TT	GDSC Cell Line Gene Expression Profiles	1.0	1.45465
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.971809
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86504
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_17027_KD_HAND2_SRP274025	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.63631
Perturb_7164_KD_FTH1_SRP385887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.08756
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RRP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17833
BRD-K39913135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19232
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51873
Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MD MB231	BioGPS Cell Line Gene Expression Profiles	1.0	0.972689
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107159
MCF7_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0297473
BRD-K99783492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57499
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20281
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.284962
superficial stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21167
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.846199
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_741_KD_KDM4A_SRP181840	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.25673
hydrolase activity, acting on acid anhydrides	GO Molecular Function Annotations 2015	1.0	null
Perturb_3017_KD_Ttn_SRP222910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.96665
PANC1	CCLE Cell Line Gene Expression Profiles	1.0	2.85794
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Domain of unknown function DUF1605	InterPro Predicted Protein Domain Annotations	1.0	null
GSE158632_2_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.97742
GTEX-XXEK-0826-SM-4BRWG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24546
Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-499a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34509
K562_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153607
Lens fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.3998
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K17889110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25505
Perturb_14188_OE_BCL7A_SRP258290	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.32395
BRD-K12524715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14751
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.6861
Perturb_2340_KD_BRCA2_SRP153058	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.50504
valproic acid_mus musculus_gpl1261_gds3002	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RENBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45652
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23256
obesity	GWASdb SNP-Phenotype Associations	1.0	0.701431
hsa-miR-642b	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42597
r9 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36461
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7C-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_KO_TESTES_627_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1437	CCLE Cell Line Gene Expression Profiles	1.0	1.45192
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07731
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K66207462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02502
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35823
rostral putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.864583
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124328
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.68319
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922189
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36671795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01551
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.396
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041762
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88634
GSE254770_3_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.30606
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDUFA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11786
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1273g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ET-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925466
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20196
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.99834
TCF4-32651957-PLC/PRF/5-HUMAN-LIVER-HEPTOMA	ChEA Transcription Factor Targets 2022	1.0	null
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168897
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KARPAS-45	GDSC Cell Line Gene Expression Profiles	-1.0	-3.21997
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09874
A549_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154512
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42464
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4SW-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
peripheral blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.300679
BRD-K95014129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06183
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42009
NANOG-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13267
Perturb_15419_KD_RNF2_SRP116142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.4947
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388091
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25653
SMAD3-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.985553
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848361
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59967
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31867
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.38054
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38718
BRD-K62184784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08127
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LEFTY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044802
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
cloned	GeneRIF Biological Term Annotations	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.09018
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85015
PMC3500769-srep00875-s3.xls-GATA3-Time_0_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CHST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05862
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28601178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03522
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78742
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11105
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-1626-SM-4DXTY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6659
Prostate adenocarcinoma_PRAD_TCGA-CH-5745-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893608
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.09271
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81919
MSL complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35674
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.15717
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116957
Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K54212583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07231
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.886084
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05326
BRD-K17285234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31673
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174003
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.12805
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66013
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_11790_KO_Cd109_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.56204
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0203
hsa-miR-3122	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21939
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144491
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178624
JHU-011	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154651
BRD-K94058780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39342
investigation	GeneRIF Biological Term Annotations	1.0	null
RHOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05595
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31772
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14474
MET_knockout_252_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.88343
BRD-K56351525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05627
A549_Rucaparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133637
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881349
MFSD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30161
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.65206
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113946
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2043
RAD21	ENCODE Transcription Factor Targets	1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174299
GTEX-RM2N-0726-SM-48FD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21115
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08258
P2RY14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563033
BRD-K90881556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37964
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-CRX_DN_V1_DN-Gene_name_CRX	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51919
lymphocytes	GeneRIF Biological Term Annotations	1.0	null
Ewing's family tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
after	GeneRIF Biological Term Annotations	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94931
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4252
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.262
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO679	DepMap CRISPR Gene Dependency	1.0	2.57343
Perturb_9337_OE_FGFR1_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.30815
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72868
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.078948
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIVF001-007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89385
GTEX-SNOS-0826-SM-4DM5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842212
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1424_KD_RUNX3_SRP159180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.36782
mrna splicing, via spliceosome	GO Biological Process Annotations 2015	1.0	null
ZNF43_01_125	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59528
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0811
USP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62768
MCF7_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169207
GABPA	ENCODE Transcription Factor Targets	1.0	null
ACY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06148
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.90324
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908977
Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.95731
EP300_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9969
NFYB	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12318_KD_NRDE2_SRP161520	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.22941
pheniramine-1992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_3102_KO_N4bp3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.83776
Perturb_10286_KO_Ypel3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.72409
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_4280_KO_Smchd1_SRP134966	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.3971
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Blood Protein Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76501
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145203
Perturb_337_KD_MYC_SRP301562	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.8417
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.915802
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HL-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
chr10_125908027_C_T_b38	GTEx eQTL 2025	1.0	2.99893
GTEX-XUJ4-1226-SM-4BOPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964239
Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE474	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.4535
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15978
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.4723
Perturb_7374_KO_MGA_ERP067388	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.64619
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.7567
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.555273
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19915
Perturb_7180_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.17008
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04274
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3185	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
K562_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172384
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOSL2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548ae	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.093784
testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138852
BRD-K56778317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24536
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131992
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	2.41561
Perturb_12671_KO_Bptf_SRP191908	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.03331
ventral entopeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16703
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.538343
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03954
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
RXRA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MONOMAC1	DepMap CRISPR Gene Dependency	1.0	2.06261
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873716
Perturb_2291_OE_TBX3_SRP184219	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.09407
nadh dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.328708
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358269
MAP3K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38076
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04474
Perturb_17241_KD_IRF1_SRP337933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.28024
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37656403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71168
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13281
r9 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17662
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17054
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NLRC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713406
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.824998
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
rna processing	GO Biological Process Annotations 2015	1.0	null
GTEX-P78B-1826-SM-3P5YX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98762
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.91237
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14263
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22103
MYC	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ELF3-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7021771-41467_2020_14684_MOESM12_ESM.xlsx-CASZ1_ChIPseq_in_Ctrl_cells-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
WNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433772
NCI-H2029	GDSC Cell Line Gene Expression Profiles	1.0	1.61063
Perturb_5630_KD_EWSFLI1_SRP340258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.31264
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97066
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.20022
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.921135
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.261559
Perturb_12200_KO_CBFB_SRP159005	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.6203
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9338_OE_HCRED_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.772
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170554
PMC4823079-oncotarget-07-2889-s007.xlsx-Feuil1-Supplementary_table_6_AEU_events_shared_by_WT1-expressinf_cells_and_fresh_AML_samples_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13526
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36437
BRD-K49409947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13249
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fhm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.38891
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
NGDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20402
r10 part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74459
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0351
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10025_KD_TIAL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.16933
BRD-K83013052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12359
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.896017
Ribociclib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0183677
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3638
Spliceosomal complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01881
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07811
Perturb_7508_OE_ILF2_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.38898
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
SW1116	CCLE Cell Line Gene Expression Profiles	1.0	1.36392
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020875
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24792
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7895
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311086
manifested	GeneRIF Biological Term Annotations	1.0	null
PF382	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22709
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85839
CRCGN014_HEPG2_3H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01166
Lung adenocarcinoma_LUAD_TCGA-75-6207-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7233-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137025
Spastic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Perturb_11775_KO_83F24Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.67779
Perturb_15527_OE_CPT1A_SRP292168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.62057
GSE68229_0_v_1_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869495
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462581
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384326
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200371
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.06872
BRD-K54484272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03251
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877446
PMC3500769-srep00875-s3.xls-PAX2-Time_0_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2741
JUN	ENCODE Transcription Factor Targets	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26311
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13793
CRCGN014_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.398
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25574
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906656
SALL4	ChEA Transcription Factor Targets	1.0	null
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899646
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12648
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
Balsalazide (sodium hydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0257225
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92882
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17959
OE21	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K21450593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08304
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59423
Perturb_8449_KD_LETN_SRP230777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.83241
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.754288
intermediate stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00344
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67398
Perturb_7506_OE_ADARB1/STRBP_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.39686
Perturb_14485_OE_Tp73_SRP134969	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.30393
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23604
Perturb_14627_KO_OGT_SRP146064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.3766
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.107
supragenual nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41399
colonrectum_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.992086
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06672
myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08666
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02734
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36743230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90648
GTEX-P4QT-1326-SM-3NMD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06021
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.393
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32144
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.950831
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4994_METTL16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522661
BRD-K03953354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20399
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150023
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PeBoW complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.693
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096628
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.699246
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.908
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446807
MARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10855
OST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02232
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27728
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.11639
BRD-K51573654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40449
Perturb_16937_KO_An_SRP287147	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.08924
BRD-K76175734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46307
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30828
CTCF	ENCODE Transcription Factor Targets	1.0	null
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5293_KO_Dgcr8_SRP137730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.20141
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22895
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U2SURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21749
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.25
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32497
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ofloxacin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191313
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12160_OE_TCF7_SRP144189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.07804
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948807
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2227	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Perturb_8158_KD_HNRNPLL_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.26252
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.104353
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77162
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.42669
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01715
Perturb_362_KD_RAC1_SRP387923	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.6845
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48851
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198038
Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spastic diplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
Waist Circumference	dbGAP Gene-Trait Associations	1.0	0.166776
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26181
Perturb_4256_KD_NCOR2_SRP326059	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.74278
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330523
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.985869
FOXP1	ChEA Transcription Factor Targets	1.0	null
widespread	GeneRIF Biological Term Annotations	1.0	null
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188317
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
atherosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.296587
HCE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4174
Perturb_2717_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1608
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53099
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132973
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04474
MONOMAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48792
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.413
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325447
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40894
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66968
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20105
EB2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.3307
JUND_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
abnormal	GeneRIF Biological Term Annotations	1.0	null
RPMI8402	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94897
Perturb_13886_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.4886
Perturb_6837_KD_TGM2_SRP194250	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.45708
hsa-miR-548am	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197393
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.961686
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
external globus pallidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18722
Perturb_4904_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05155
PTTG1IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90686
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1506
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04497
Water	HMDB Metabolites of Enzymes	1.0	null
Perturb_9402_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.59092
Perturb_11842_KO_Stra6l_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.31465
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.855829
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5975
Hypertension_Adrenal gland_GSE1674	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.03414
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149079
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Temuterkib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0152435
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Malotilate_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0234083
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A3M1-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29019
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040437
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Perturb_10444_KO_miR29b_SRP075398	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.11595
Adenosine triphosphate	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906089
PMC5195898-NIHMS825571-supplement-6.xlsx-Sheet1-267_CIC_response_genes_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90345
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rectum_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.878289
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175261
NSMAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08083
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13958_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.06912
RL7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.961484
CREM	ChEA Transcription Factor Targets	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833024
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21322
ChIP_TCF3_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843058
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14508
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3638_KO_BRD2_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.8851
PMC3500769-srep00875-s3.xls-AP1-Time_0_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H0-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
periventricular stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74296
anion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.255
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2721_KD_YAP1/WWTR1_SRP115100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.9598
t-lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.365633
BRD-K55142307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04509
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.938902
Acute Myeloid Leukemia_LAML_TCGA-AB-2912-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.125
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2617
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77609
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48102
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FD-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3500769-srep00875-s3.xls-AP1-Time_24_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15769_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.4651
Perturb_5306_KO_Tet1/Tet2/Tet3_SRP101434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.93579
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05586
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17121
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76680796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13615
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1227
BRD-K07526417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09757
RFX5	ENCODE Transcription Factor Targets	1.0	null
BRD-K58836556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21895
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20093
A549_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212872
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMAD3-22036565-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3500769-srep00875-s3.xls-GATA3-Time_4_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880077
P31-FUJ	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52509
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09524
U4/U6 x U5 tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.982
NCI-H322M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE220520_3_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56283
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.824473
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41656
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88286
Perturb_9035_KD_FOSL1_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.78267
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.984889
GSE239844_7_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Malignant tumor of pancreas_saliva_GSE14245	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.24859
Astrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874342
Perturb_6856_KD_CNOT1_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.88475
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.67923
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.334865
anterior digastric muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20891
Kidney Chromophobe_KICH_TCGA-KN-8431-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50864
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.39869
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
Prostate adenocarcinoma_PRAD_TCGA-EJ-5511-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GIMEN	DepMap CRISPR Gene Dependency	1.0	4.11696
MHHCALL3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46671
Body Mass Index	dbGAP Gene-Trait Associations	1.0	0.058228
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665869
HuH-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
BRD-K93933512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78042
Perturb_5660_KO_ID2_SRP336141	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.8409
Perturb_3937_KO_DBC1_SRP371865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.87416
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248155
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85614
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.3982
Perturb_5289_KD_Rpl10a_SRP064202	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40881
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11955568-41467_2025_57429_MOESM9_ESM.xlsx-Data_S7-JUN_OIS_Martinez2020_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.051941
Perturb_17612_OE_MYC_SRP301619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.87706
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016197
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81686
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Perturb_12704_KO_LIPA_SRP310406	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.9339
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20686
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27885839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6495
E2F1	ChEA Transcription Factor Targets	1.0	null
SERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56965
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76394
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K79753227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33815
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12894
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
activated	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-548n	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03323
p2 portion of the substantia nigra pars compacta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04592
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.14454
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53141
CLCNKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486299
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ixazomib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169153
myeloid leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31335
BRD-K35520972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32017
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72569
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_2391_KD_PRKDC_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.68976
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.395
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874624
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03904
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54844
MCF7_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168286
Perturb_6788_KD_NUDT21_ERP122260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.88604
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.53106
HEL9217	DepMap CRISPR Gene Dependency	1.0	2.09319
Perturb_9061_KD_NANOG_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.683
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19891
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
FOSL1	ENCODE Transcription Factor Targets	1.0	null
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042993
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92675
BRD-K66581298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.86176
Perturb_6408_KD_LINC00152_SRP134387	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.80517
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207763
Sarcoma_SARC_TCGA-X6-A8C3-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00233837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24059
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871604
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2865-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1669
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.971667
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956297
SH2D2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006103
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20914
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-1.48835
BRD-K59683187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02732
FDXR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452323
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306964
Perturb_4928_OE_KLF17_ERP131959	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.524
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941003
BRD-K35429561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4119
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05094
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201432
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TALL1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24053
Superior central nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16811
periventricular stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03219
Perturb_15751_KO_Zfp36l1_SRP285762	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.59924
BRD-K40189164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.32636
TOLEDO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.873266
Kidney Chromophobe_KICH_TCGA-KM-8477-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_Activation - 8 hours_GDS2025_725_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48905
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05689
chr10_125909657_G_A_b38	GTEx eQTL 2025	1.0	1.3905
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06322
ACHN	GDSC Cell Line Gene Expression Profiles	1.0	1.7652
Perturb_9289_OE_KRAS_SRP172671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.7079
CRCGN016_MCF10A.TP53.M_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2066
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05293
BRD-K00191683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30894
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	1.75147
GTEX-S341-0626-SM-4AD5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78492
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
obesity	GWASdb SNP-Disease Associations	1.0	0.805638
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832177
KPNYN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78788
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VC-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eNoSc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.855
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73318
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_1267_KD_Prmt7_SRP279352	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.55045
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144024
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.30117
Perturb_17316_KO_Tardbp_SRP321767	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.99105
BRPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25776
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40505
HCT116	CCLE Cell Line Gene CNV Profiles	1.0	1.48931
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34781
GSE148066,GSE157787_2_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LDLRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15296
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126305
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52633
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33693
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOSL2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
17880687-TableS2	GeneSigDB Published Gene Signatures	1.0	null
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196423
KE37	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55236
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86518
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	1.0	1.41514
GSE182179_0_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUN_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94789179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02465
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KOPN8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46768
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179676
Perturb_9288_OE_KRAS_SRP172671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.85302
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65791
granular layer of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11954
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20518
additional	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOSL2_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99950451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49851
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301134
H1_BMP4_Derived_Mesendoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.863481
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endometriosis_Endometrium_GSE7305	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.72286
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MIF_DEPLETION_GDS3626_95_human_HEK293 kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K05000526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19635
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2695_KO_SET1B_SRP089784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.57844
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154996
lateral part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01821
MCMBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485635
Perturb_15477_OE_MYC_SRP218384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.48282
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239976
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dhx32	GeneRIF Biological Term Annotations	1.0	null
BRD-K81706364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71632
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15849
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223379
GSE102870_1_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lymph node	HPA Tissue Gene Expression Profiles	-1.0	-0.995816
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10999
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.99675
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
FOXA1-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TE-5	GDSC Cell Line Gene Expression Profiles	1.0	1.88879
YY1	ENCODE Transcription Factor Targets	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.21191
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
coronary artery disease	GWASdb SNP-Phenotype Associations	1.0	0.608153
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47304
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN74	CCLE Cell Line Gene Expression Profiles	1.0	1.45611
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.899121
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
MHH-CALL-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3496
MITF	ChEA Transcription Factor Targets	1.0	null
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LU-99A	COSMIC Cell Line Gene CNV Profiles	1.0	2.14116
MCF7_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175827
EP300_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.080662
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.031089
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.14703
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144753
BRD-K48835953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65793
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
MCF7_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171667
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EVPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76926
Perturb_16698_KO_83F24Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.54679
Perturb_4531_KD_Senp6_SRP060878	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38321
ChIP_POU5F1_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054736
KLF5-20875108-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142336
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_4488_KO_Rnu11_SRP309496	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63609
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320253
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890718
cell part	GO Cellular Component Annotations 2015	1.0	null
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.86461
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.907308
Perturb_8870_KD_PNN_SRP063860	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.8017
BRD-K03056434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16093
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06147
Perturb_7397_KD_DHX38_ERP132987	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.94142
NCIH524	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68674
HCC202	CCLE Cell Line Gene Expression Profiles	1.0	1.41696
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25133
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Myeloid leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2013
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30607
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900946
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856977
Main olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15664
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23594
homeostasis	GeneRIF Biological Term Annotations	1.0	null
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28592
KIF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40654
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65932559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23346
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.253
Furosemide_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0128742
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9949
peripheral blood lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301398
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OVK18	CCLE Cell Line Gene CNV Profiles	1.0	1.52516
Lung adenocarcinoma_LUAD_TCGA-78-7536-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5517-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT3-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PK-01A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7312_KO_CASC3_ERP118046	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.84496
r1 part of dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64523
Abiraterone acetate_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0321732
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22839
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.27126
COR-L321	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
TMEM203	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09591
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29915
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1806	CCLE Cell Line Gene CNV Profiles	1.0	1.32949
Sympathetic ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3147
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07172
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.847266
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36821
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875922
BRD-K24748087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22324
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ewing's sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
Ciclopirox_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0184935
PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29R-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08713
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10201
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68867
Lung adenocarcinoma_LUAD_TCGA-55-8087-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27278
GTEX-VUSG-1226-SM-4KKZF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61391
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039409
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280783
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44027
leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Ouabain (Octahydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0120951
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.40178
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.28057
GSE214382,GSE214383_0_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.345
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4672	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26745
GSE187005_5_v_2_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.828503
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R7-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.13667
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4462
Perturb_15692_KD_SLFN5_SRP051401	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60018
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_3586_KD_KHSRP_SRP250831	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.72959
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.964657
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70351
AHSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46305
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tyrphostin AG-1478-1141	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.378
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B5-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00213
RNF128	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057072
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144134
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PSG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00458387
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.6446
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.41582
GTEX-UJHI-0826-SM-4IHLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42237
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.33182
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.20182
REC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.46577
Perturb_12946_KD_METTL3_SRP106608	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.91307
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.173314
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109329
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76296
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3500769-srep00875-s3.xls-AP1-Time_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18177
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142598
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12158
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07313
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.413332
OTS514_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0205517
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244461
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5266_KD_neg_SRP331021	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.11446
spliceosomal complex	GO Cellular Component Annotations 2015	1.0	null
specifically	GeneRIF Biological Term Annotations	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0984
TCF7	ChEA Transcription Factor Targets	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K90366266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09122
Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958141
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.853199
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	70.462
SMC3	ENCODE Transcription Factor Targets	1.0	null
BRD-K36144252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30518
periventricular stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15032
BRD-K39016838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39196
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COGAR359	DepMap CRISPR Gene Dependency	1.0	3.59597
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012056
Perturb_11782_KO_Asb15_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.66711
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6737
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956334
short	GeneRIF Biological Term Annotations	1.0	null
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155285
Arsenic	CTD Gene-Chemical Interactions	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985154
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02895
CRCGN015_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21048
SNU668	CCLE Cell Line Gene CNV Profiles	1.0	2.00838
MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.89518
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.952181
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271986
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39215
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02964
Sigmoid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
BRD-K44814060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39316
correlation	GeneRIF Biological Term Annotations	1.0	null
CTXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26356
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43170571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04508
Perturb_7202_KD_DHX9_SRP080966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.3678
binding	GO Molecular Function Annotations 2015	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHOS-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHLDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7461
cflip	GeneRIF Biological Term Annotations	1.0	null
Perturb_3864_KD_INSR_SRP333146	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6845
KIAA2013	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39389
tcell	GeneRIF Biological Term Annotations	1.0	null
Perturb_10279_KO_Lyplal1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.95909
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31437957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10123
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EWSR1_KD_GDS4962_468_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_2598_KD_PRMT6_SRP131294	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.06251
UQCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31473
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNMC-0626-SM-4DM6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991148
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40936
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.13141
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4899
BRD-K10105458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68698
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08746
metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-A00522887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08691
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11156
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05682
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MYOD1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3532_KD_PTBP1_SRP310663	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.258
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154811
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10666_OE_HSPB2_SRP288471	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.154
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null