association	dataset	threshold value	standardized value
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATXN7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12032
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9441
Loperamide (hydrochloride)_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0129559
NCIH1793_LUNG	CCLE Cell Line Proteomics	1.0	3.62591
GSE149075_8_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
VDAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2397
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40232
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_4_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SU8686_PANCREAS	CCLE Cell Line Proteomics	1.0	2.04802
Decitabine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0137937
UPCISCC029A	DepMap CRISPR Gene Dependency	1.0	6.64629
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178340_7_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNUC2A_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.9334
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.929056
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.578081
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Angelman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
Coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
RPMI8226	DepMap CRISPR Gene Dependency	1.0	3.5396
PPP6R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12805
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.4934
SNU739	DepMap CRISPR Gene Dependency	1.0	3.50892
Autosomal dominant intellectual developmental disorder 41	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.616
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33966
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143148
GSE226285_2_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116492,GSE116495_3_v_1_stag2_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.24233
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228162_2_v_1_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Type VI protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.464
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2619
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301176
PMC11285331-cd-23-0539_table_s1_suppst1.xlsx-Lost_AR_Peaks-Unnamed_19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prospore contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
Golgi-associated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.82594
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144484
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
Ivabradine (hydrochloride)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0129642
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
regulation of smooth muscle cell apoptotic process	GO Biological Process Annotations 2023	1.0	null
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
AZD-7648_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183871
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE156033_1_v_2_sparc_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCLFUPGI0005T	DepMap CRISPR Gene Dependency	1.0	6.29599
GSE210101,GSE210114_4_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Vemurafenib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0138449
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.07372
PMC11214527-mmc5.xlsx-NFATC3-gene_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
RHOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46961
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10332_ZNF397_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520415
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.87459
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cilostazol_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0162604
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09712
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Trametinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222945
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hesperidin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192317
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.418
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Acetohexamide_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0208137
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Childhood disintegrative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7925689-41467_2021_21687_MOESM10_ESM.xlsx-A_HIF1A-Unnamed_8_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Trachea	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8626
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Golgi membrane	GO Cellular Component Annotations 2025	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6531
POLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13213
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.48278
Encorafenib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217243
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.26
Congenital muscular dystrophy-dystroglycanopathy type A12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
negative regulation of smooth muscle cell apoptotic process	GO Biological Process Annotations 2023	1.0	null
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149744
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175920_0_v_1_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08759
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Elagolix sodium_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0125768
Extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134572
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL72	DepMap CRISPR Gene Dependency	1.0	2.75283
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
positive regulation of protein serine/threonine kinase activity	GO Biological Process Annotations 2023	1.0	null
striated muscle cell proliferation	GO Biological Process Annotations 2023	1.0	null
Glycyrrhizic acid_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0169853
HeLa-MAGI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.159
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.64297
FIGLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63014
EN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34244
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.965
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPFIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04229
ZNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10262
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4823
NRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32962
GSE188774_1_v_0_hkdc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peretinoin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0179341
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO205_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.74717
USP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36158
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145029
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175920_4_v_3_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Golgi membrane	GO Cellular Component Annotations 2023	1.0	null
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.632
Variola minor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Basket cell_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.034
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF775	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06611
MCF7_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111736
Peretinoin_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0320188
Methylprednisolone succinate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260177
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149296
GSE210093_3_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Xcp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.331
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-HSLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IGSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42328
Plicamycin_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192002
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175920_0_v_2_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.583
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
LAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07713
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134682
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191986
GSE123887,GSE123888_2_v_1_hpgd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rett syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014822
MCF7_Crizotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00927364
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
SLC25A25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22216
N4BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02596
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NTS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33119
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE111035,GSE111040_10_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE67266_7_v_4_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188870,GSE188871_0_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6814198-NIHMS1538462-supplement-2.xlsx-Transitory_415genes-SNAI2_SNAI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218739
Cobimetinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242505
MCF7_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121257
9720_VENTX_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559995
GSE196671_5_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173201_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.211
YKG1	DepMap CRISPR Gene Dependency	1.0	2.54898
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COQ8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18659
RMC-6236_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0254048
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196699_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246195,GSE246305_1_v_3_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110954
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255489
TMK1	DepMap CRISPR Gene Dependency	1.0	2.54157
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_significantly_downregulated_739_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-442_common_elements_in_HIF1_peaks_and_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.5184
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Orlistat_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182196
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50495
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4872073-supp_gkv1528_nar-02930-x-2015-File004.xlsx-Table_S2A-CREB1_Target_Genes_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133854
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123033
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209582_1_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Torkinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300222
Zinc levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC8285542-41467_2021_24656_MOESM4_ESM.xlsx-Sheet1-The_genes_positively_or_negatively_correlated_with_TP63_in_SCC_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUIT2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.73874
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO Biological Process Annotations 2025	1.0	null
GSE145323,GSE145324_9_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228125_2_v_1_ptafr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARL6IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44229
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0579
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
496100537_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15237
PMC6683136-41598_2019_47363_MOESM4_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202473
Periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.551
H3118	DepMap CRISPR Gene Dependency	1.0	4.20373
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.577934
NAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0574
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of protein kinase C activity	GO Biological Process Annotations 2023	1.0	null
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0644
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06556
9-ING-41_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0333048
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Niclosamide (olamine)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.026473
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41639
Tooth germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.627
Selinexor _HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0118635
TMEM50A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08323
GSE102870_5_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5431
DNMT3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63104
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Benproperine (phosphate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.011972
PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
ADO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49979
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9176
Aliskiren_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0151731
SPTBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34497
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109164
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	3.80752
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7068
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162977
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE149075_3_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34861
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.9248
Zileuton_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132259
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143675
Filgotinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0150069
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE30_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.27378
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4319
BB30HNC	DepMap CRISPR Gene Dependency	1.0	7.89948
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Berbamine (dihydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0254328
MCF7_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117882
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DTP3_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241799
MCF7_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171169
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29903
Fulvestrant_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0351223
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SDHAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57854
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr3_143988009_C_T_b38	GTEx eQTL 2025	1.0	1.57327
ANKRD13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17699
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100572_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.42252
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Smith-Magenis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
PRKAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59541
BLZ-945	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.84427
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.8177
KIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07376
PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TTI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72537
Belinostat_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.029656
Olanzapine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0165187
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.8327
NDUFB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63739
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.614946
DNAJC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16389
GSE196540,GSE196542_2_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dorzolamide (hydrochloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255123
cardiac muscle cell proliferation	GO Biological Process Annotations 2023	1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.502
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3878
PMC9174176-41467_2022_30924_MOESM6_ESM.xlsx-OC2-SYMBOL_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
Pimitespib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0277231
regulation of protein kinase C activity	GO Biological Process Annotations 2023	1.0	null
BTBD18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11087
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.84385
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Trimetrexate_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294277
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9167
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
MKN45_STOMACH	CCLE Cell Line Proteomics	1.0	2.26764
ZNF544	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30054
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0017
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29125
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209307
MCF7_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158434
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8218_SNRNP27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617986
Basimglurant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2612
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COPI vesicle coat	GO Cellular Component Annotations 2023	1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.1656
COPI-coated vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
PCSK1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5533
TMEM242	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03056
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-29-ZFHX2_ZFHX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134191_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4728380-ncomms10153-s11.xlsx-Seitz_Burkitt-SEITZ_MYC_TARGETS_BURKITT_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Idoxuridine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0158723
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAP1L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13119
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.8678
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NKTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19885
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7021771-41467_2020_14684_MOESM8_ESM.xlsx-CASZ1_specific_peaks-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.16986
GSE109285_5_v_4_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47669
MAP3K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10533
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181966_0_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Methylprednisolone succinate_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226327
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carbidopa (monohydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0375251
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.86643
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233667
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vesicle coat	GO Cellular Component Annotations 2023	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.670779
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HA1E	DepMap CRISPR Gene Dependency	1.0	2.46676
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4873
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.02
Sonidegib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0259603
Type IV secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.223
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57334
GSE149075_2_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11165526-ADVS-11-2310146-s002.pdf-30-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-ZNF43_ZNF43	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13442
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0136
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0726
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3977
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0529
Specific language impairment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
MCF7_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155029
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Multiple synapse bouton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115395_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744274
ZFAND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09372
Anthranilate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
Rhabdomere	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.942
S-layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
PMC11615365-41467_2024_54246_MOESM5_ESM.xlsx-RT112-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
1541_CGGBP1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539046
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.491126
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-down-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.853
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223303
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4476
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
496100345_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01609
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7004
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44617
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463714
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46345
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542862
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175920_0_v_3_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAD2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74112
GSE115363_3_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VPS33A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12119
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TE11_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	3.35309
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of smooth muscle cell apoptotic process	GO Biological Process Annotations 2025	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	83.4585
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NAPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23136
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0843
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221004_1_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569541
Pierpont syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
ZNF562	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29499
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ST6GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63463
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHLA90	DepMap CRISPR Gene Dependency	1.0	2.19136
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227698_5_v_3_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6599263-13073_2019_654_MOESM2_ESM.xlsx-CAR1_tsv-gene_name_NR1I3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7373278-pone.0236187.s013.xlsx-T47D_genes_overexpressed_in_AR-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4860404-Table2.XLSX-MR_unique-Table_S2-7_DEG_unique_in_mouse_and_rat_SCI_at_3_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8283158-mmc2.xlsx-TCF4_Glut-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112995,GSE132079_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of muscle cell apoptotic process	GO Biological Process Annotations 2023	1.0	null
SCH	DepMap CRISPR Gene Dependency	1.0	3.80625
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.958
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7071
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cinacalcet_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248589
CCLP1	DepMap CRISPR Gene Dependency	1.0	3.32686
chr3_144870385_A_T_b38	GTEx eQTL 2025	1.0	1.95304
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
BI-78D3_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0219223
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1471
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.7778
GSE196699_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
Dorsal lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
m9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.939
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VMRCRCW_KIDNEY	CCLE Cell Line Proteomics	1.0	2.74461
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525035
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.202
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.2566
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6413
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
PMC9046280-41467_2022_29963_MOESM5_ESM.xlsx-ASCL1_motif-Gene_Name_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
GSE129389_0_v_7_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Phelan-McDermid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3514_GPR89B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54239
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.878821
Roxadustat_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0351505
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.7536
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pyridoxine (hydrochloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0235754
positive regulation of protein kinase C activity	GO Biological Process Annotations 2025	1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.9577
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04244
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145035
Ciclopirox_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0277784
ACTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28071
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Raltitrexed_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268315
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00912222
PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vinblastine (sulfate)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321846
SHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03631
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.0
GSE127970_1_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200404
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15663
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Miz_KD_up_Myc_KD_up_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF460	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71463
GSE148066,GSE157787_2_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE84678,GSE93902_3_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.866
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Triamcinolone_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.022375
Silodosin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0283271
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_3_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100582_HIP_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63774
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136206
Ataluren_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0436284
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hexylresorcinol_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0390661
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3599
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217405_0_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nde	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.294
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49047
Periodontal ligament	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
MCF7_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135081
AURKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24883
Outer membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.455
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Talc_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155295
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE67266_5_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152637_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
GSE143782_7_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cabozantinib (S-malate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0389883
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23216
MERO83	DepMap CRISPR Gene Dependency	1.0	5.41177
PCI6A	DepMap CRISPR Gene Dependency	1.0	7.85682
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6482
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28828
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-RREB1_mod_RREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Golgi membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.3925
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5735185-41467_2017_1200_MOESM4_ESM.xlsx-Table_S1-Choi_et_al_2016_DUX4_up-regulated_targets_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Tranilast_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171649
Asperger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.2297
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3315
Quinestrol_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260216
PARP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41659
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207914_4_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of intracellular signal transduction	GO Biological Process Annotations 2023	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	1.11297
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123147
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETC-206_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0254955
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.5859
Tetrindole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
Alate adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98755,GSE98756_1_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45579
GSE203308_1_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
toxin-antitoxin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.185
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEL270	DepMap CRISPR Gene Dependency	1.0	2.54229
LB771HNC	DepMap CRISPR Gene Dependency	1.0	6.53818
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00837549
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab5_KDM5C-KD-down_genes-Table_5_Down_regulated_genes_in_KDM5C-KD_KDM5C-KD1_Control_overlap_KDM5C-KD2_Control_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE161771_0_v_1_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.818529
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.739045
RHOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16687
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TERB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27957
AGRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04448
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.094
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.548361
GSE231648_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bubonic plague	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
Macrolide transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
ZBTB49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03667
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Total body bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.709691
Multiple synapse bouton, contacting single dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.574
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
Captopril_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0372443
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128939
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016653
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_6_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Membrane coat	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TENT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59281
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21362
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11043338-41523_2024_637_MOESM1_ESM.pdf-133-DDIT3_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434025
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7837
AZD1390_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00876582
C16orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08275
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	3.73291
AU565_BREAST	CCLE Cell Line Proteomics	1.0	2.9334
GSE196540,GSE196542_4_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.969
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_SMC_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Right nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
Asi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
GSE129772_2_v_3_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1345
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180951_6_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CFAP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31297
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTDSPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25517
MCF7_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115264
PC14_LUNG	CCLE Cell Line Proteomics	1.0	2.70039
PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KP2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.14285
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7088
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10771438-41598_2023_51082_MOESM1_ESM.xlsx-Day14-Supplementary_Dataset_1_List_of_genes_differentially_expressed_during_NS_PC_differentiation_between_ROR2_KD_cells_and_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11408861-mmc2.pdf-11-DDIT3_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170926
GSE227698_5_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_increase_in_MLL-AF4_ChIP-seq_signal_371_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AT9283_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112776
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37292
MCF7_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183718
Coated membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Roxadustat_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206711
Ponatinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0314105
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_2_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oxaliplatin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0177025
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Potocki-Lupski syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
MSL complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.403
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240111
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
vesicle coat	GO Cellular Component Annotations 2025	1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8157
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YH13	DepMap CRISPR Gene Dependency	1.0	5.53299
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178340_7_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2243
Vesicle coat	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11415
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195786_3_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016038
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-2_E2F1-Gene_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218171_1_v_0_foxn3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Vandetanib_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0105315
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.19888
General risk tolerance (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_RORC-Logfold_change_threshold_1_0_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3333
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207012
IFIT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87327
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of muscle cell apoptotic process	GO Biological Process Annotations 2025	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Afatinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0340929
Fluvoxamine_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00831471
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Nafamostat (mesylate)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0279709
PMC9546828-41389_2022_435_MOESM5_ESM.xlsx-Table_S4-Table_S4_Upregulated_genes_upon_ZNF148_knockdown_P_adj_0_05_Fold_change_1_5_ZNF148	Rummagene Transcription Factor Associations 2026	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346619
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Indacaterol (maleate)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0309841
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.766
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
NP8	DepMap CRISPR Gene Dependency	1.0	2.60265
Conjunctival UV autofluorescence (CUVAF)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.639794
Posaconazole_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.026937
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9236
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-RREB1_mod_RREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
olaparib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237788
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01305
GSE226285_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180200,GSE180201_3_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tadalafil_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.044993
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160138
GSE223008_6_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237475
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Finasteride_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0314673
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Irinotecan (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282068
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.735921
Dexmedetomidine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217326
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Multiple synapse bouton, contacting multiple dendrites	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217405_0_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.1785
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	3.63485
Squamous cell lung carcinoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23581
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Inhibitory synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
COPI-coated vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
ATP7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24084
PMC4860404-Table2.XLSX-MR_specific-Table_S2-9_DEG_specific_for_mouse_rat_SCI_at_3_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6408
WASL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61824
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.5693
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269688
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DCAF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01527
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-TM_KO_vs_WT-Supplementary_Table_S2-2_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_TM_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175920_4_v_2_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
CHL1DM	DepMap CRISPR Gene Dependency	1.0	12.9294
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cementum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2977
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-29-ENSG00000136367_ZFHX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Fedratinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138244
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675959
GSE149075_8_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bisoprolol (hemifumarate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0207396
Abiraterone acetate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206165
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13204
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.819361
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.722631
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59513
Alveolar bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.488
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240137
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.0543
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Harringtonine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00942072
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340171
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
H357	DepMap CRISPR Gene Dependency	1.0	3.35971
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC7A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05597
Neratinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219164
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08582
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anastrozole_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0316222
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0649
Ascidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Dimethyl fumarate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258161
Prefoldin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
GSE77108_3_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138818_1_v_3_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243951
VASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00973
MKN7_STOMACH	CCLE Cell Line Proteomics	1.0	3.0796
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
venetoclax_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0286216
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210526
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.301
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
Larotrectinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0150481
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119564_2_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Automobile speeding propensity	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Radotinib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255826
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39649
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NDUFS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10811
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Fragile X syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
Altretamine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027448
Compound-1a	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16497
GSE158182_3_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9019027-42003_2022_3332_MOESM3_ESM.xls-Table_S1_HUVEC_MED23-KD_DEGs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
F36P	DepMap CRISPR Gene Dependency	1.0	2.30393
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.367
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5673
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
bacterial-type flagellum hook	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21514
MCF7_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018033
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.831
PMC11615365-41467_2024_54246_MOESM5_ESM.xlsx-RT112-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MK-3903_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192805
cardiac muscle cell proliferation	GO Biological Process Annotations 2025	1.0	null
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171401_1_v_2_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132645
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.592785
SLC35A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63444
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6933
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3649
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Larotrectinib sulfate_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240532
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SEC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1225
Dental follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.864
PSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30458
Coated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSKH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55992
Fingolimod (hydrochloride)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146805
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.751664
KDM3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29372
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.20168
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	133.992
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COPI vesicle coat	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	5.49208
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.916834
XRK3F2_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.015498
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305345
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3932
PMC7918644-LSA-2020-00974_TableS2.xlsx-6_SAd2_D_BD-SOX2_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_3_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SBI-0640756_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0316379
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.92977
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488286
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132528
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39529
WM3211	DepMap CRISPR Gene Dependency	1.0	8.83677
HNRNPUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4441
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Trametinib (DMSO_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0417877
LGI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04568
PMC11923864-ADVS-12-2413713-s002.xlsx-Fe3O4_SiO2_NP_of_LTF_spike-in-Unnamed_0_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bacterial-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE100102_4_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tirabrutinib (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184387
PRRC2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60985
Tirabrutinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0313066
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229698_1_v_2_traf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of intracellular signal transduction	GO Biological Process Annotations 2025	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11285331-cd-23-0539_table_s1_suppst1.xlsx-Lost_AR_Peaks-Unnamed_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
olaparib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0276985
Vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC6617737-13059_2019_1747_MOESM1_ESM.xlsx-Table_s9_OLIG2_DEG-Gene_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
U2OS	DepMap CRISPR Gene Dependency	1.0	3.57799
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FYTTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18903
PMC11056319-43018_2024_736_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_PRMT9_KD_signature_used_for_ICB_response_clinical_trial_analysis_FC_2_p_0_05_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
XRK3F2_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0280103
MFE296	DepMap CRISPR Gene Dependency	1.0	2.40488
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SKMEL30_SKIN	CCLE Cell Line Proteomics	1.0	2.91027
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Niclosamide (olamine)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00847965
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319819
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3617
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
EXOSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00618
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
GJA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21422
GSE245407,GSE245412_0_v_1_smurf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.924
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112709
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218512
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JMSU1	DepMap CRISPR Gene Dependency	1.0	5.90469
Bromfenac	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
PROSER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2535
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8681
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
TAK-733_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0128554
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9266
HNRNPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68752
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48015
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acral lentiginous melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3253
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270174
GSE158100,GSE158101_1_v_0_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1566
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138899
GSE111035,GSE111040_3_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54577
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111660_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.668474
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2426
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC29A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3939
DNAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4652
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6431
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bosentan (hydrate)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0217394
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
Granulosa cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Riluzole hydrochloride_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0179243
ZBTB16-27035670-HESC-HUMAN-ENDOMETRIAL	ChEA Transcription Factor Targets 2022	1.0	null
Infigratinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265391
Rhabdomere membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.011
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2566
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133516_5_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brimonidine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0282854
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
COPI-coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206312
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Canagliflozin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203524
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx BloodVessel 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-9.82582
positive regulation of protein serine/threonine kinase activity	GO Biological Process Annotations 2025	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.054
Erlotinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0382082
Tirabrutinib (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0141174
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
SNU449_LIVER	CCLE Cell Line Proteomics	1.0	3.92041
Gingival fibromatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type V protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.678
GSE175920_4_v_1_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Darolutamide_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0124462
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.417
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_PanPC_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
4EGI-1_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.022029
MCF7_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171029
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149096_2_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.0016
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2164
NCIH2052	DepMap CRISPR Gene Dependency	1.0	2.26334
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GAMG	DepMap CRISPR Gene Dependency	1.0	5.37552
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180185_4_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195786_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Radotinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.023666
RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
SW579	DepMap CRISPR Gene Dependency	1.0	4.96483
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2784
regulation of phosphatidylinositol 3-kinase signaling	GO Biological Process Annotations 2023	1.0	null
GSE226091,GSE226092_3_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.286
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNRPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21039
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96057_1_v_2_oma1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Darinaparsin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0225604
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
CP21R7_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00868245
GSE184133,GSE184137_1_v_9_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109285_3_v_4_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2994
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Selinexor _SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00972792
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYBBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02143
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.62313
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Golgi-associated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Spreading_targets_gene_names_163_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Osimertinib (mesylate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0373707
Type IC spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Epothilone A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113665
PMC3985196-317853.f1.pdf-40-ZNF528_ZNF528	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-Veh_KO_vs_WT-Supplementary_Table_S2-1_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_Vehicle_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Omeprazole_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231123
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139307
Gefitinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196281
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.11827
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235682_1_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Planktonic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.14
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9516
8742_TBR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511392
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
H2BC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46903
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Artesunate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0395763
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
COPI-coated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.024
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHRDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24296
HEC6_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	4.61604
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striated muscle cell proliferation	GO Biological Process Annotations 2025	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.1256
Polyphosphate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.749
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157381
OSC19	DepMap CRISPR Gene Dependency	1.0	2.19908
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ligustrazine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0263778
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dexamethasone_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245298
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-ZNF43_ZNF43	Rummagene Transcription Factor Associations 2026	1.0	null
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH1581_LUNG	CCLE Cell Line Proteomics	1.0	2.17215
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Golgi-associated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.154
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
5-Azacytidine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162259
BIRC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19487
YD8	DepMap CRISPR Gene Dependency	1.0	2.70251
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COPI vesicle coat	GO Cellular Component Annotations 2025	1.0	null
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HI-TOPK-032_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0154807
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Atazanavir (sulfate)_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145747
Extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
AR-35413990-HUMAN-ARPOSCRPROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012588
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100316_3_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of smooth muscle cell apoptotic process	GO Biological Process Annotations 2025	1.0	null
Pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
AZD2858_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00815409
MCF7_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130303
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.28255
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACBD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.044
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5406
Pyridoxine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0110592
GSE148066,GSE157787_3_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30697
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111895
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EPHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18018
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162199
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Syndromic X-linked intellectual disability Turner type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
PMC10203545-Table_4.xlsx-LM7_underrepresented-DMRTA1_DMRTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endothelial cell_Liver_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143944_1_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.8977
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225949
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-LPS_VS_LPS_PDLSC-CM_776-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
Dexamethasone_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179705
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
CAS1	DepMap CRISPR Gene Dependency	1.0	2.7875
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
METTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04404
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215428
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Estrone sulfate (potassium)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0265572
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.60902
GSE199543,GSE239447_0_v_6_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of protein kinase C activity	GO Biological Process Annotations 2025	1.0	null
11078_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556908
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129772_2_v_1_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_12_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Docetaxel_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123719
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C16orf86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03507
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0110703
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.818504
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160346
COLO684	DepMap CRISPR Gene Dependency	1.0	2.24865
Type III protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.091
L363	DepMap CRISPR Gene Dependency	1.0	2.55703
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Flumatinib (mesylate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0376198
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.41808
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102870_11_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fetal serum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
Cepharanthine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0282211
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146872
PMC9174176-41467_2022_30924_MOESM5_ESM.xlsx-OC3-SYMBOL_ONECUT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132017
PMC7021771-41467_2020_14684_MOESM8_ESM.xlsx-CASZ1_specific_peaks-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309016
MCF7_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00935575
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143296
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Muscular dystrophy-dystroglycanopathy type C12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LJI308_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0356302
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pralsetinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0127908
Bestatin (hydrochloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181117
ZNF652	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00858
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dental plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
SETD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54374
8666_TAF5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01842
Retinoic acid_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0092298
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.791