association	dataset	threshold value	standardized value
Encysting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347634
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.30476
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H510A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K35004659_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J4-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO Molecular Function Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-7273-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM34_02_141	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.58496
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18921
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.265038
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IMR32	CCLE Cell Line Gene Expression Profiles	1.0	1.49696
ARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81667
BRD-K75775113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52829
SNU478	CCLE Cell Line Gene CNV Profiles	1.0	2.00261
BRD-K05002317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40435
hsa-miR-4732-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
BRD-A43126523_NCGC00183690-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852292
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dendrite terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.048
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.922105
HMGN3	ENCODE Transcription Factor Targets	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90928
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72984
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42812
PMC7825356-8844261.f3.docx-48-IKZF5_IKZF5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2855_Mut_SPOP_SRP404927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.35115
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17627
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2863-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33979719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62977
BRD-K11476310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47135
acetylsalicylic acid-4428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trichostatin A-7499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06412
hsa-miR-4488	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE202434,GSE202438_3_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
7472_RPL3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.73088
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15891
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04147
CDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1797
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54166
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051847
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58141
TPRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24504
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322058
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13068347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44322
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20863
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280494
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.09751
EZH2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
PMC7161353-supp_073353.119_Supplemental_Tab_S8.xlsx-BRCA_HRGs_correlation_to_MBNL2-gene_name_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02953
SBC-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25111
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04469
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14874
ChIP_SOX2_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900599
PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268644
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08569
BMI1-19503595-MEFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K26738018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31436
EIF3J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7752
trichostatin A-7324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_RXRA_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.15958
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
9829_WDR55_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34198
TTC642	DepMap CRISPR Gene Dependency	1.0	5.4717
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52543
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78195641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18154
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.489447
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.693393
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
doxorubicin-5671	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861074
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.12328
CCFSTTG1	CCLE Cell Line Gene Expression Profiles	1.0	1.40536
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45728
TASK1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98142
tooth enamel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297447
BRD-K04704273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49929
HC toxin-909	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
n1e-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.656648
BRD-K97867712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24436
GTEX-XMD1-0526-SM-4AT4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837136
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09031
Enamel epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.009
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897856
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.168148
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859064
r9 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9455
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-2426-SM-4LMI6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12707
PMC5414054-ncomms15013-s11.xlsx-SupplementaryData10-Supplementary_Data_10_Genes_differentially_expressed_due_to_infection_in_IRF5-_-_compared_to_parent_KOLF2_cells_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040346
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.439728
GSE204832_0_v_1_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100345_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06023
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18911
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06372
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4143_KO_Bcl11a_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.2549
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64777
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200867
16417408-Figure4	GeneSigDB Published Gene Signatures	1.0	null
Calu-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
1898_CSNK1A1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.66984
PMC3672751-bcr3403-S15.XLS-Sheet1-BCL11B_BCL11B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE132759_4_v_5_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SJXC-0226-SM-2XCDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877493
MCM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05806
VMRC-LCD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K21466747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30984
HNF4A	ChEA Transcription Factor Targets	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0544
valproic acid-6999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MZ1-PC	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94944
TDRD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86172
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79523
KPNYS	DepMap CRISPR Gene Dependency	1.0	5.75801
trichostatin A-3979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53106
MMP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04803
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRSK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90723
DB-18-UF01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219976
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2866
Acute Myeloid Leukemia_LAML_TCGA-AB-2830-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-USF2_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
2,6-dimethylpiperidine-3806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATM_knockout_74_GSE23116	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.51856
BRD-K72675584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31591
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.17615
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15527
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10492
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864178
BRD-K52872067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05565
dicoumarol-3423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4308	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42337
AF-80-GK24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294959
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71504
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A267-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10042887-41419_2023_5742_MOESM4_ESM.xlsx-Table_S4-Table_S4_Overlap_genes_of_HOXB3_vs_HOXB3-_and_APC-KO_vs_APC-intact_HOXB3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72310865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29978
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.969664
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.630676
intermediate stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70966
BRD-K59984972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63061
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
BRD-K11404512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30622
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277577
PMC4122406-pone.0104158.s010.pdf-22-DLX5_DLX5	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853174
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4225-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZI-1426-SM-3NB1T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18208
UOK101	CCLE Cell Line Gene CNV Profiles	1.0	1.3659
BRD-K11631766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30047
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18559
Apical dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.982
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hematuria	CTD Gene-Disease Associations	1.0	1.19737
FES	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29888
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.286983
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16809
mediodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05387
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1321
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S12-Table_S12_MR_resluts_of_brain_pQTL_and_any_ischemic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
REST_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STARD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00433
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31142
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178312_0_v_1_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
alveolar bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223662
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZB-72-PE17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353704
CCRF-CEM	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65987
SEMA3A	Pathway Commons Protein-Protein Interactions	1.0	null
JAK1_knockdown_160_GSE37012	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63424
GTEX-S4Q7-0626-SM-4AD5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15592
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30949
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365764
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72885
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7951
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.7041
TNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27655
intermediate part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42894
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58604
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21469
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03434
PHF8	ENCODE Transcription Factor Targets	1.0	null
Perturb_11575_OE_YAP_SRP273175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.68039
YY1	ENCODE Transcription Factor Targets	1.0	null
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.573616
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942933
Ascites	CTD Gene-Disease Associations	1.0	1.08126
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13089873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38489
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06702
BRD-K43992612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13568
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97688
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.911593
7437_RPL13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.76715
Perturb_13_KO_Pbx1/Pbx2_ERP125157	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-3157-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46765
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.558982
GSE184133,GSE184137_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.407
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.568286
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
trichostatin A-7179	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chr10_132188644_C_T_b38	GTEx eQTL 2025	1.0	3.56673
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.687625
1129_SPOUT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06418
norethisterone-2383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21894
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242432
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28743
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.063923
MED14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64826
4116_INCENP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54488
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4892
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35303
system development	GO Biological Process Annotations 2015	1.0	null
BRD-K80888333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33257
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25330450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11863
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937637
ChIP_KLF4_19030024	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37691127_Hinokitiol_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.669193
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059559
PMC7161353-supp_073353.119_Supplemental_Tab_S8.xlsx-LUAD_HRGs_correlation_to_MBNL2-gene_name_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11493601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35222
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18259
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377661
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T8-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442144
hsa-miR-548v	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.86668
GSE219274,GSE219276_3_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.50639
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.80548
Neurosphere_Cultured_Cells_Cortex_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.06566
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.41655
trichostatin A-6879	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
autonomic nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.652484
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73762
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Superior colliculus, superficial gray layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27164
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829676
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.780232
BRD-K34700473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04546
trichostatin A-5511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4697-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Infertility, Male	CTD Gene-Disease Associations	1.0	1.59826
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24695
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.48998
Rectum adenocarcinoma_READ_TCGA-G5-6572-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC2245955__F5	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K20644549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22454
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5199-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22435870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09753
hif1a_16565084_mcf7_lof_human_gpl2507_gds2761	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.758496
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487461
clozapine-6988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COR-L23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-3332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hel	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
GTEX-R55G-1026-SM-48FDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963056
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0019
Thymus gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
PMC6766969-PATH-249-90-s005.xlsx-S1_b-Supplementary_Table_S1_b_Top_100_upregulated_and_downregulated_genes_in_TAF15-NR4A3_vs_EWSR1-NR4A3_EMC_NR4A3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98115
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.11673
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898243
BRD-K40565784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.073
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41868
hsa-miR-342-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKAG3_KO_GSE4063_389_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59916
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26509
GDM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.08266
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AA-92-NW83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216536
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal temporal lobe morphology	MPO Gene-Phenotype Associations	1.0	null
ADCY7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503162
AURKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00818427
NEDD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42472
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5048
DPYSL5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-24-KQ98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229942
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32256
IFNA16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589979
filamin binding	GO Molecular Function Annotations 2025	1.0	null
fascicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.487886
TPSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46552
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.78
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59855
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19372
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HSPB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03576
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K20259776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51543
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17714
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35954
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976582
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.51735
Granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.405
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4322
Liver Failure, Acute	CTD Gene-Disease Associations	1.0	1.13007
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859408
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.07429
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52C-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU840	DepMap CRISPR Gene Dependency	1.0	2.45787
MBD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5938
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
NCI-H747	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.22956
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35809
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17614
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63303
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863068
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KQ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20117
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0626-SM-4LVLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966671
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4576
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.11673
MEF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7546
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26156
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.668904
Enamel knot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_6_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
CEP350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67728
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854294
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
MARK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19005
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13546
CAL-148	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50521
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-449a	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
SLC25A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12559
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35836
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05899
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10352
trichostatin A-4954	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-4112	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
naringenin-3278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05622
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999442
tooth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.17506
Perturb_14539_KO_Kras_SRP311976	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65438
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80753
axon guidance	GO Biological Process Annotations 2015	1.0	null
Superior central nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04996
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216097
hsa-miR-125b	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
BRD-K25147028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00422
CHP126	CCLE Cell Line Gene Expression Profiles	1.0	2.49033
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260267
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	GO Molecular Function Annotations 2023	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
CRMPs in Sema3A signaling	Reactome Pathways 2014	1.0	null
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pyrimidine nucleobase metabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15455
Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p53	GeneRIF Biological Term Annotations	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62591
PMC5787431__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869156
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17573
GE-98-ZI68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482482
3599_GUCD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20002
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09434
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03014
SLC43A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03391
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57946
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_8_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864354
GCIY	CCLE Cell Line Gene CNV Profiles	1.0	1.55832
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106491
hsa-miR-1255b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
4499_LAMB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25002
Lung squamous cell carcinoma_LUSC_TCGA-21-5786-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
vorinostat-6939	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07063
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51804
trichostatin A-6910	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04221
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.26374
intermediate stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25662
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969261
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
Chlorodiphenyl (54% Chlorine)	CTD Gene-Chemical Interactions	1.0	null
PMC10869968-jcav15p1568s1.pdf-3-ANKZF1_ANKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
ECC12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE158834_1_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
biperiden-4684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23929
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39016838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10203
CEPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12015
BRD-K72238567_656402-250MG_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21164
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6171
BRD-K69396470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09681
Cell body fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.613
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267596
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32826
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_16425_KD_APP_SRP187586	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.44244
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5046
7460_RPL32_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28709
JUND	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02913
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33597
BRD-K27049948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61723
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	191.722
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
valproic acid-989	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K00697836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01365
trichostatin A-6993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	3.97068
NGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537233
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JO-01B-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208373
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29289
OUMS23	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67538
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.0297
dihydropyrimidinase	GeneRIF Biological Term Annotations	1.0	null
MOB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99871
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31706
BRD-K24848743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06639
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07453
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60563
BRD-K22610244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16082
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.875629
hsa-miR-449b	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.889249
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIMY7	DepMap CRISPR Gene Dependency	1.0	4.84838
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-2.31206
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hESC_Derived_CD184+_Endoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.877174
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Retrosplenial area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54697
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JEG-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28742
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31836496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46053
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.69433
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07768
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.665529
Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379875
1841_INTS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09883
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.89732
harman-4584	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trichostatin A-5209	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34243
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4233
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6045
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52696
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98321
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.07482
developmental process	GO Biological Process Annotations 2015	1.0	null
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51774
KP2	DepMap CRISPR Gene Dependency	1.0	5.17774
6871_PSMD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	6.53191
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50685439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05573
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29876
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02462
7504_RPS15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.396
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48483
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91897
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
estradiol-7000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Actin filament bundle of actin-based cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
7498_RPS10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21375
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1943
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_17673_OE_PGRA_SRP252069	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.58414
7427_RPF2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.19014
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-5484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA2_156_TCF7_rep1_sorted_peak-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
r9 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52749
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30194
BRD-K58586013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78571
BRD-K22949587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60087
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.54459
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.49003
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10718
MB21D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08444
Medial group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54545
abnormal telencephalon morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72773309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43151
Multiple Organ Failure	CTD Gene-Disease Associations	1.0	1.01814
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-6276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4602
BRD-K89742282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23487
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38189757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16513
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59013
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988124
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KCNQ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29352
BRD-K23232542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76723
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364886
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hearing Loss	CTD Gene-Disease Associations	1.0	1.09541
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0526-SM-3P61C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960402
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58884
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29806
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83099
rhombomere 10	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23525
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67669
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36801
SW1417	GDSC Cell Line Gene Expression Profiles	-1.0	-1.9022
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49005
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
5196_MRPL13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75307
parahippocampal gyrus, right, bank of the cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.971184
RDES	CCLE Cell Line Gene Expression Profiles	1.0	1.70036
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.3126
FZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58912
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89573
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31762
GSE186112_1_v_0_med23_human	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370794
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274757
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.861834
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33001
trichostatin A-3395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21946
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961396
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84078
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S13-Table_S13_MR_resluts_of_brain_pQTL_and_large-artery_atherosclerotic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278511
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SUZ12-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DOID:11575	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.141
REV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21975
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05973
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.30727
trichostatin A-4388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883199
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217357
PMC6438015-13148_2019_651_MOESM7_ESM.xlsx-Sheet1-Table_S2_Genes_exhibiting_both_significantly_increased_promoter_methylation_and_significantly_lowered_expression_in_CRISPR_TET2-KO_cells_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.540657
BRD-K35004659_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8377_KD_MAGEA3_ERP120445	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NEUROG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33508
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15163
GSE193624_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08249
Cellular metabolism and vesicular transport regulation	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15016
L-363 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NPIPB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76841
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.48864
GTEX-P4QS-2026-SM-3NMCG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859869
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30031
BRD-K95763144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69669
apical dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.487307
EGR2_01_243	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67208
BRD-K58445641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70638
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2125
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42017
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
ZFPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24259
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0511
Genomic Instability	CTD Gene-Disease Associations	1.0	1.35934
rectum_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.935825
GSE229698_1_v_2_traf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-491-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K92291448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05855
rectum_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.834778
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229279
BRD-A04975445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22307
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855316
BRD-K08533345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09108
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTHrP_KD_GDS1664_71_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
abnormal synaptic plasticity	MPO Gene-Phenotype Associations	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971075
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Anteroventral nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28531
GSE232631_0_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5732_NOL10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.76935
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6213
Perturb_3016_KD_SNHG1_SRP313438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1478
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0367
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196540,GSE196542_4_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-UNCX_UNCX	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978859
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02462
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15548
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_NR0B1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.854089
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05915
Perturb_11574_KO_miR375_SRP273175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.57269
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915047
cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.916069
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
trichostatin A-6434	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
oligodendroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.602088
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_15576_KD_ETS1_SRP044013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.6708
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
Cystic Fibrosis_Lung_GSE3100	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.49877
trichostatin A-6493	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16472
BT474	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94752
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07235
r9 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87624
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0873
SUZ12	ChEA Transcription Factor Targets	1.0	null
embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.444676
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.826168
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.978865
superficial stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1085
EIF1AD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4499
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3E-AAAZ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF2	ChEA Transcription Factor Targets	1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.407
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263952
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.39353
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994349
trichostatin A-5950	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
leflunomide-6102	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.907484
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33956
NOXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89008
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.38045
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK5R1	Pathway Commons Protein-Protein Interactions	1.0	null
Medial habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41355
9172_TONSL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30587
craniofacial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286736
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68168
BRD-A51777634_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955316
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3966
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.52708
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08436
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23449
RNF2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41524
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_downregulated_RRHO_list-CREB1_opposite_genes_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222134
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6158
PMC8755441-mmc3.xlsx-IRF7-Up-SUZ12_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.12564
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.46567
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.503861
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5347
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06372
abnormal nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469896
abnormal forebrain morphology	MPO Gene-Phenotype Associations	1.0	null
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K17315445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15208
VU-0418933-1	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04517
GSE119978,GSE180930_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.846281
medial part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0784
ECC10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1999
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.996953
SOX2-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_10235_KD_EXOC5_SRP187300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83485
abnormal synaptic transmission	MPO Gene-Phenotype Associations	1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.774434
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
cytosol	GO Cellular Component Annotations 2015	1.0	null
ADK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00473277
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81175414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18225
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939166
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.4977
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26744
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	1.0	3.35606
trichostatin A-4821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12706
PMC7587013-GLIA-68-2613-s005.xlsx-ASCL1_Putative_Targets-Overlapping_Genes_ChIP-seq_8791_ASCL1_Assoc_Genes_vs_TCGA_RNA-seq_2136_Top_10_ASCL1-positively_Correlated_Genes_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
KLF4-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1072-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.636111
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S14-Table_S14_MR_resluts_of_brain_pQTL_and_cardioembolic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08038
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11356
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968719
7513_RPS24_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22968
mRNA_REST_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Actin filament bundle of filopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.688
PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
medial portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.921795
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3179
VPS26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47881
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5077-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82271
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96485138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37294
BRD-K14019014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17132
NCIH226	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32319
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZB-16-BR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.437052
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
trichostatin A-2881	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2BBE1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87627
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SYK_druginhibition_154_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.68742
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A824-06A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
impaired synaptic plasticity	MGI Mouse Phenotype Associations 2023	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.09791
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77694
PCDHB15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71108
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.33245
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0291
enamel epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.627485
GSE210682_0_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5855
LATS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05902
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.744214
BRD-K71857815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98117
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nervous system development	GO Biological Process Annotations 2025	1.0	null
trichostatin A-5260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48046422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11553
BRD-K45916030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37285
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K90881556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00224
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05081
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	171.138
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_SOX15_CUT_Tag_top_10k_peaks_Related_to_Figure6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.407
BRD-K02061146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14572
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12690_KD_GRASLND_SRP192895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.129
r8 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41154
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51416
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.479312
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P5-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MERO41	DepMap CRISPR Gene Dependency	1.0	2.60873
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10883
palmatine-2795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944581
16455954-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59087082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97581
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.917101
Lung squamous cell carcinoma_LUSC_TCGA-21-5783-01A-41R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_REST_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29916
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62219570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23934
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	0.86795
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal hippocampus pyramidal cell layer	MPO Gene-Phenotype Associations	1.0	null
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357628
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92274
GSE195568_2_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DE-82-SC55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205466
Coma	CTD Gene-Disease Associations	1.0	1.254
ESPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49004
Lung squamous cell carcinoma_LUSC_TCGA-60-2724-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ5-0926-SM-3TW8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1345
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06616
MAX	ENCODE Transcription Factor Targets	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_3Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.41827
abnormal ammon gyrus morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11653
Headache	CTD Gene-Disease Associations	1.0	1.12082
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CEBPG_CEBPG	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-5945	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bepridil-4613	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K08307026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34412
5162773-892	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	177.348
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5901
TUHR10TKB	CCLE Cell Line Gene Expression Profiles	1.0	1.42748
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34833
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04408
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE80098,GSE80366_0_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.371619
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50049
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pyridoxine-7171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-0726-SM-48TCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09146
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64977
Nicotine addiction_Ganglioneuroblastoma_GSE11208	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.0931
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31637
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38347
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10160_KD_TNFAIP8_SRP271403	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91589
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26503698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01327
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430526
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.83845
TEAD4	ENCODE Transcription Factor Targets	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2394
superficial stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16856
BRD-K89402302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34795
ciclopirox-3317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_1236_KD_RBMX_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.2149
GSE203429_0_v_1_angptl8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90744477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32773
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04714488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35688
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.514236
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.726097
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.252
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CCK81_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.08056
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41124
BRD-K10564128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03648
TMEM221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31419
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19Q-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.10246
hsa-miR-4802-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4859-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65598536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28996
ACC3	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.10252
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31955163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36255
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15569
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19785
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.68041
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213908
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42832
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34099
trichostatin A-6932	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845904
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
BRD-K21620541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36174
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990895
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4684_KD_Plag1_DRP005364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.5658
SLC7A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17493
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8277-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55088
SEC62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14138
ECT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25683
trichostatin A-2330	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LIVF001-002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64972
REST_Panc1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r8 part of the paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27676
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
erythromycin-1510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SK-N-SH	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07902
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YW-3026-SM-3MJHI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976577
RARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00475
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2893_KO_Nfia_SRP077282	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.2033
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49469
BRD-K58041870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21941
Ataxia	CTD Gene-Disease Associations	1.0	1.32428
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28873
BRD-K87062384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21339
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.059
clindamycin-7172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17602
INTS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73994
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
r7 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43054
MAZ	ENCODE Transcription Factor Targets	1.0	null
Perturb_2154_KD_SPRY1_ERP114848	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.77352
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX1-22343733-PBMC-HUMAN-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16605
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.59041
ChIP_REST_18959480	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
chr10_132186587_G_A_b38	GTEx eQTL 2025	1.0	1.31036
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.26841
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55299
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11386
18535662-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1339
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.92523
ciclacillin-4536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847125
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80926
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26037
NACC1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Vomiting	CTD Gene-Disease Associations	1.0	1.3385
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
villus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.194126
DIFI	DepMap CRISPR Gene Dependency	1.0	3.39545
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47583
BRD-K09432998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29917
BRD-K47865468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57076
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS79	CCLE Cell Line Gene Expression Profiles	1.0	1.6162
BRD-K03849840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47477
LCLC103H	DepMap CRISPR Gene Dependency	1.0	3.09424
CHP-126	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.22364
FBXO28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00106
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69903018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06158
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.8757
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66218
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05254
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6602
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08036
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TF-29-QU48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290704
Sarcoma_SARC_TCGA-DX-A6B8-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.944807
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835566
profenamine-3038	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K01022714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42104
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.97841
KLF4-18264089-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organic cyclic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12374
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
H4K20me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41524
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.94045
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
RB1_KD_GSE50532_657_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95295
Secondary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72359187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02915
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8156
Bmi-1_KD_GDS2724_102_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.98014
GCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01919
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K88806312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49994
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Weight Loss	CTD Gene-Disease Associations	1.0	1.80961
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K97470305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28638
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394176
bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.553546
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9992472-41467_2023_36735_MOESM6_ESM.xlsx-Late_SOX11_gene_signature-Unnamed_1_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
medial part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16825
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08993
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35742
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4158
medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262645
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.646509
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500678
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27624
intracellular part	GO Cellular Component Annotations 2015	1.0	null
solasodine-4305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
damage	GeneRIF Biological Term Annotations	1.0	null
down	GeneRIF Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0376
Contractile vacuole pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.101
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838725
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K91784140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08952
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.29073
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27107
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965346
SUZ12-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09333
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1795
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890956
MDAMB361	DepMap CRISPR Gene Dependency	1.0	4.34571
SUIT2	DepMap CRISPR Gene Dependency	1.0	3.1028
Perturb_16435_KD_APP_SRP187586	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.604
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.76764
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7479_RPL7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.72291
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03483
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_NR2F2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
Basal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.011
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32454
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10158
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860086
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
alprostadil-7358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13677_KD_DHX9_SRP018815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.14931
Perturb_7543_KD_HSF1_SRP275505	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SNU1544	DepMap CRISPR Gene Dependency	1.0	4.22724
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GCT	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.69353
BB-65-SY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40623
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	128.565
r9 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42055
ELK1	JASPAR Predicted Transcription Factor Targets	1.0	null
NAXE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07289
RAJI	DepMap CRISPR Gene Dependency	1.0	2.39779
ciclopirox-5023	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7220_KO_EED_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-z_e_o_To_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7787
GSE102675_2_v_1_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
trichostatin A-6579	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36582
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.14716
A3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
451Lu	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.08425
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_2572_KD_HIF1A_ERP004269	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.56115
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
3446_GNL3L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01004
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303762
Epithalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63316
BRD-A89441445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15145
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48342
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27514
BRD-K73689413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31925
BRD-K31554491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11518
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.81259
hsa-miR-4721	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15236
C32	DepMap CRISPR Gene Dependency	1.0	7.06493
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.31617
zonal layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18867
trichostatin A-7043	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4647
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
metamizole sodium-2175	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874627
trichostatin A-5693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HIV encephalitis_frontal cortex_GSE3489	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.37591
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240192
Transnitrosylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40709
Perturb_78_KD_BAP18_SRP074464	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.18814
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00521
BRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75604
fetal	GeneRIF Biological Term Annotations	1.0	null
RTRAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86635
SKMEL31	CCLE Cell Line Gene CNV Profiles	-1.0	-2.50924
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00216
BRD-K89093471_VU0418934-2_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893887
7968_SLC16A5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52904
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.882509
telmisartan_rattus norvegicus_gpl4135_gse29445	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ5-0426-SM-3P612	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924257
MHH-NB-11	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.2716
BRD-A77941182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42157
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22343
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H520	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.00469
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69653
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07044
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06668
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883478
abnormal hippocampus morphology	MPO Gene-Phenotype Associations	1.0	null
S100A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34321
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49382
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4426
ZNF501	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29559
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
17699775-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37445
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-1.30476
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93537
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11356
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0813
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	3.19384
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941969
trichostatin A-6951	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal hippocampus region morphology	MPO Gene-Phenotype Associations	1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211305
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.48048
Perturb_2982_KO_TP53_SRP287851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.3591
19168792-TableS3	GeneSigDB Published Gene Signatures	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61032
INA6	DepMap CRISPR Gene Dependency	1.0	2.65073
Perturb_6752_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.4927
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77P-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05060234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56893
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.8557
deferoxamine-573	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.392629
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5568-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL5RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561224
7459_RPL31_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70531
CDK5	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S5-Supplemental_Table_S5_Genes_commonly_downregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09036
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02307
JNK_KO_GDS3001_531_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12754
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.52558
ZRANB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39771
estradiol_homo sapiens_gpl571_gds4063	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11631946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15536
BRD-K52956006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08837
Dentate granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
REST	ChEA Transcription Factor Targets	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3728595-srep02327-s1.pdf-1629-ZNF181_ZNF181	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38979
MKN45	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.37624
BRD-K19770687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19005
NANOG	ChEA Transcription Factor Targets	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.645563
BRD-K14875480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68525
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
pancreas	HPA Tissue Protein Expression Profiles	-1.0	-1.06544
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A88381870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15079
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211894
BRD-K84956158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47153
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1797
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63264
trichostatin A-2777	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HuH-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
V-79-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.05107
valproic acid-433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27397
Perturb_2551_KD_BRD4_SRP040136	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CA46	CCLE Cell Line Gene CNV Profiles	-1.0	-2.38854
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223934
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
nucleobase-containing small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84388444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14532
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.648854
DNAAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31535
BRD-K56884305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23289
BRD-K65860773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49078
PRKAG3_KO_GDS1398_703_mouse_gastrocnemicus muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245359
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17958
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060237
Perturb_2424_KD_SHARPIN_SRP068943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NB1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.89475
BRD-K18801549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03847
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45561
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.603
1458_CDT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12508
OVMANA	DepMap CRISPR Gene Dependency	1.0	2.48056
NCI-H2122	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07992
prazosin-5416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0612
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
r3 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16856
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2433
daunorubicin-7507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
Orbital area, ventrolateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35565
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1139
7442_RPL18A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22592
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10613
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50827
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
site of polarized growth	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.764072
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45858
USF1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8279-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238451
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39343
vorinostat-5580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055853
IPC298_SKIN	CCLE Cell Line Proteomics	1.0	2.83559
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.946126
BRD-K58576935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60427
Developmental Biology	Reactome Pathways 2024	1.0	null
16166195-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.23754
BRD-K14719962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1218
SYK_KD_GDS3609_440_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52452
SMC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09311
GSE114272_0_v_1_clk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UCHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44216
7474_RPL4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	4.44843
GTEX-S33H-0826-SM-4AD5Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998226
hydrocotarnine-4489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852704
C3A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GPR108	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34765
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2605_OE_SEPTIN9_SRP159553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.82925
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal hippocampus layer morphology	MPO Gene-Phenotype Associations	1.0	null
Dendritic growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.373
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8261-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_259_KD_PBRM1_SRP358304	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.528
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_14699_KO_TET1_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.73083
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66312
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9388
RNF2	ChEA Transcription Factor Targets	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3023
Orbital area, medial part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84778
PMC6078853-molce-41-7-695-suppl2.xlsx-Sheet1-Table_S1_Genes_exhibiting_two-fold_changes_in_expression_between_WT_and_CTCF_KO_otocyst_with_FDR_less_than_0_05_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29165
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.849413
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33645
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11319
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.54235
BRD-K81795824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02732
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Growth cone filopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5595
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.977475
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23278
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00745
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25236
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40021
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416688
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rifabutin-4349	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8898_THUMPD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09091
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HY-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163111
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36849
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
controlled	GeneRIF Biological Term Annotations	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH524	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40487
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	198.376
trichostatin A-1659	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epiphysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.653807
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32897
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.978865
chr10_132178433_G_GA_b38	GTEx eQTL 2025	1.0	1.73114
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3273
Trolox C-1734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7521_RPS29_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08595
NRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07128
COLO205	DepMap CRISPR Gene Dependency	1.0	2.69347
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
CDK5RAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4274
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6199
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.162
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BMI1	ChEA Transcription Factor Targets	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.867574
Anemia, Hemolytic, Autoimmune	CTD Gene-Disease Associations	1.0	1.03084
BRD-K62621376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57923
RC-52-AC88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28629
trichostatin A-1637	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32370845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61758
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579879
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842907
BB-69-YQ35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224958
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13735
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dihydropyrimidinase activity	GO Molecular Function Annotations 2025	1.0	null
18245496-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25402
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S15-Table_S15_MR_resluts_of_brain_pQTL_and_small-vessel_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.984189
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02913
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5457
Perturb_6849_KO_PRE2_SRP273076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.45223
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Enamel organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
BHT101	DepMap CRISPR Gene Dependency	1.0	2.21728
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.41035
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832776
trichostatin A-7005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881536
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03938
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062529
SYK_KD_GDS3609_441_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02782
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327952
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_28_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Thymoma	DisGeNET Gene-Disease Associations	1.0	null
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21035
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
trichostatin A-2835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trichostatin A-5987	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.36582
BRD-K20549184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15107
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851221
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.9951
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QB-42-MC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293958
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22442
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06372
BRD-K95653016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00734
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.27966
ChIP_KLF2_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
carbamazepine-835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28767
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38194
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36593
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.848132
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73722
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.07206
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28008
Osteosarcoma	CTD Gene-Disease Associations	1.0	1.06008
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7525_RPS3_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.83117
INHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48002
cranium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288158
BRD-K82768815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27369
GSE207728,GSE207808_2_v_1_c646_human	RummaGEO Drug Perturbation Signatures	1.0	null
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01705
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900191
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.931671
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-7173-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.88532
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00638
A549_Fluorouracil_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00731659
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953503
SUV39H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12255
Aflatoxin B1	CTD Gene-Chemical Interactions	1.0	null
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18644
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66753
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_19_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CORL279	DepMap CRISPR Gene Dependency	1.0	2.79514
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49256
fluocinonide-4314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92712671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37186
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.7872
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216416
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07547
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-ARGFX_UP-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_up_to_an_FPKM_of_at_least_2_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369268
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896946
HEL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63475
SRSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20501
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.01549
prostate_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.961741
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46928
PMC6718408-41467_2019_11884_MOESM9_ESM.xlsx-YAP1_RELA_DEGs_mice_human-Human_Gene_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	0.857074
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5501-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61717269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00806
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42013
abnormal limbic system morphology	MPO Gene-Phenotype Associations	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08288
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	199.538
rifabutin-4527	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44579
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.544329
SIN3B	ChEA Transcription Factor Targets	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.929767
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866258
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48831
NCI-H2444	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PSMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44909
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.830661
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219875
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
DEL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81779
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55242
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895839
Limbic encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873746
STK746869	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.973876
myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.259591
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19593
SMARCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07004
pyrimidine nucleobase metabolic process	GO Biological Process Annotations 2023	1.0	null
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.631205
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	0.949119
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC2694838-1471-2164-10-241-S3.xls-Sheet1-Commonly_altered_genes_by_ZNF191_overexpression_and_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Arrhythmogenic Right Ventricular Cardiomyopathy_Myocardial tissue_GSE4120	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.43914
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848334
Endometrial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
icSARA deltaORF6_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.37905
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2087	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69807
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885498
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-5940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chr10_132183527_C_T_b38	GTEx eQTL 2025	1.0	1.29849
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-7503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7443_RPL18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.9322
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064311
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.683371
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.715528
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.978865
GTEX-S95S-0426-SM-4B64I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875985
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-5231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system development	Reactome Pathways 2024	1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JO-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.028
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972313
Ciliary neurotrophic factor receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.919809
Lung adenocarcinoma_LUAD_TCGA-50-6591-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dihydropyrimidinase activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831145
KP-N-YN	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.44501
r2 part of median raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13733
4780_MAK16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.78625
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.583592
KMS21BM	CCLE Cell Line Gene Expression Profiles	1.0	1.54525
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
5637	GDSC Cell Line Gene Expression Profiles	-1.0	-2.76284
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14397
BRD-K00685640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04959
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.2876
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Semaphorin interactions	Reactome Pathways 2014	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.83528
PANC0504	DepMap CRISPR Gene Dependency	1.0	2.7439
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.99229
Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21108
BRD-K77591784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86361
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.406
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4803-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202368
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75253
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0431
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27488
SH3GL1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_18400_KO_Wnk1_SRP247391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.31504
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876913
chr10_132204497_G_A_b38	GTEx eQTL 2025	1.0	4.95465
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961558
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04809
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05336
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34485
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02196
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.898781
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10145
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17834
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267544
7469_RPL38_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.08677
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49039
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.431
BRD-K33697018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33197
GSE166004_3_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889524
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02525
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02053
BRD-K93268593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49116
NCI-H1651	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Semaphorin interactions(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
DTYMK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00319858
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90451
8271_SON_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24944
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37028
BRD-K75293299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00919
trichostatin A-3428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K20437312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48304
SAMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79697
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6018
BRD-K71505729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47823
Memory Disorders	CTD Gene-Disease Associations	1.0	1.34227
GTEX-POYW-1126-SM-48TCI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841289
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SE5C-1126-SM-4BRWZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958734
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46899
BRD-K34506374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08777
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825598
trichostatin A-992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
kdm5a_17320163_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse6945	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.073716
Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF5-18264089-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
gabexate-7357	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocytic patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAGE_knockout_268_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.54404
NCI-H740	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.03137
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44797874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18151
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.98625
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8726
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6212
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.828348
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0688
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44997
PL4	DepMap CRISPR Gene Dependency	1.0	7.64261
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81501
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C1QTNF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04982
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53309
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07348
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.31416
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88804
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878973
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NZM42	DepMap CRISPR Gene Dependency	1.0	2.85622
CHP-134	GDSC Cell Line Gene Expression Profiles	1.0	1.8569
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900689
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-67-PV87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207364
SNU685	CCLE Cell Line Gene Expression Profiles	-1.0	-2.09533
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pain	CTD Gene-Disease Associations	1.0	1.07553
BRD-K48557872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39943
NEK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00417995
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14692
POLR2G_02_09	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61667
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.0319
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81418486_vorinostat_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.728975
15150091-Table4	GeneSigDB Published Gene Signatures	1.0	null
OD-09-LH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256574
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24491
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.895048
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256736
GAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43037
lisuride-1545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49215099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38108
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67097
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
Anterior group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20583
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30884
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6200_KO_Firre_SRP076940	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.22953
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45484
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26735
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871422
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL70	DepMap CRISPR Gene Dependency	1.0	6.09705
Rhabdomyosarcoma	CTD Gene-Disease Associations	1.0	1.17464
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.19131
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
18535662-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.984019
BRD-K96547094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67369
Calu-6	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.10534
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-1126-SM-3LK78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10993
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.339
L-363	COSMIC Cell Line Gene Mutation Profiles	1.0	null
rosiglitazone-5593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.52187
NCI-H929	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02923
ZNF723	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32996
Cholestasis	CTD Gene-Disease Associations	1.0	1.08726
BRD-K25596713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08273
LYRM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70355
RHBDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50831
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27983
GTEX-O5YT-0426-SM-3MJHD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977903
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.913942
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29588
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43915
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46498
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41793
PMC2245955__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Retrosplenial area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96392
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03142
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54891
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G8-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.06544
Polyradiculoneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
QSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16104
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7510_RPS20_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40557
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0137
KASUMI2	CCLE Cell Line Gene Expression Profiles	1.0	2.153
Postsynaptic Golgi apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491029
BRD-K45223163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19746
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336476
BRD-K18688395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12442
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
thiamine-7479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-2.09944
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MT4	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59369
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.26629
BRD-K09615275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13986
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863535
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.482817
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08081
15886297-Table1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25262
SLC7A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00345441
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.26041
Perturb_16910_KO_Ezh2_SRP314053	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.95765
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43447
Trichocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
EIF2AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29306
tanespimycin-1006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05701
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.65352
movement of cell or subcellular component	GO Biological Process Annotations 2015	1.0	null
Thrombocytopenia	CTD Gene-Disease Associations	1.0	1.01437
SIMA	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.27607
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306783
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877676
acepromazine-4494	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.943659
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ML-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.738854
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K84054400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08407
PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91277
H3K9me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
19377508-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93223696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14303
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08828
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969208
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948991
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
trichostatin A-1014	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06819
S1PR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467927
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.24024
pyrimidine nucleobase metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1615
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ADCY7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1731
POU5F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27062
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.3162
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06416
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-1226-SM-4BRWV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.15783
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39872
GTEX-U3ZN-0926-SM-4DXTU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19544
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K27885385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00076
ANKRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39644
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.82631
6154_PDCD2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13899
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K51577368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10763
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.40176
7499_RPS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30299
filamin binding	GO Molecular Function Annotations 2023	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.45269
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Actin cortical patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33759
BRD-K92317137_-666_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K97377031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73116
superficial stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0554
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
BRD-K59670689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91508
r9 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27495
ELK1	ENCODE Transcription Factor Targets	1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32014
DCAF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75728
periventricular stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11331
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851919
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848537
BRD-K11566982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80072
BRD-K76551930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32656
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10025
abnormal cerebrum morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K79347397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30022
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SMURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36033
Perturb_8671_KD_PKP2_SRP035559	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08828
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.902683
LTK	MSigDB Cancer Gene Co-expression Modules	1.0	null
Subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.717
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85453
peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.36704
medullary hindbrain (medulla)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15827
KLF4-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50136
Katanin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
BRD-K16686330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.79713
NDUFA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66123
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.857995
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.34923
BRD-K94452277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36837
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229604
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94592
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0601
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	184.691
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.52743
KYSE-450	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327527
subiculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.90307
BRD-K76904668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02795
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3335-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K60188481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49576
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal hippocampus pyramidal cell morphology	MPO Gene-Phenotype Associations	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.3752
DYNC1LI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57239
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.996
BRD-K17367110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27575
Perturb_4306_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.65098
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230845
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78328
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44804
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior cingulate area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23198
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40233
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.82716
ATP6V1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42236
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K73610817_NCGC00183371-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
single-organism catabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_4144_KO_Bcl11a/Bcl11b_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Perturb_13213_KO_Yap1_SRP059253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.02733
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64248
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062923
TCF12	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-2.33201
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.37661
ARID3A	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NB69	GDSC Cell Line Gene Expression Profiles	1.0	1.67084
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057567
PEX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10549
BRD-K32403186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10586
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SCC-15	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44232
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04878
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KURAMOCHI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.85081
vorinostat-6980	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053346
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_KLF5_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TCFL5_TCFL5	Rummagene Transcription Factor Associations 2026	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.530963
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94498
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07287
hsa-miR-423-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
FAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39256
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35852
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.56879
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GAK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2829
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10285
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1651	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13617
UE-90-AA63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207572
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06845
Perturb_278_KD_ZHX2_SRP343502	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10963
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.41
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393704
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89788
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.8046
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25254
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.274439
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14501_KO_Tgfb3_SRP020224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.71354
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.57516
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17553
BRD-K13211285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29264
7445_RPL21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.91628
BRD-A52377240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12936
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
SKNBE2	CCLE Cell Line Gene Expression Profiles	1.0	1.99476
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054928
DGUOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49457
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876565
BRD-K75545951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25153
KLF2-18264089-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063017
SRSF9_02_134	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.70044
RRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63911
SKNMC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38621
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81795824_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77711
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00246
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF4-18264089-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-670	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.2318
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71302
trichostatin A-5417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.02709
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241934
pyrimidine-containing compound catabolic process	GO Biological Process Annotations 2025	1.0	null
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859947
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.8315
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4201
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RH-1	GDSC Cell Line Gene Expression Profiles	1.0	1.43724
HDAC1	ENCODE Transcription Factor Targets	1.0	null
trichostatin A-5594	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040539
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32905
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24429
GSE195568_2_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-94-ZA83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.788283
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865749
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03685
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60072
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935829
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.437205
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14221
BRD-K84170953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44709
lmo4_17452977_mcf7_lof_human_gpl570_gds2789	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.05342
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62839
BRD-K37262603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11351
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48665080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35713
Superior colliculus, zonal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92021
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Alternating esotropia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
NR0B1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
OAW42	DepMap CRISPR Gene Dependency	1.0	4.03464
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857043
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40364
apoptosisinducible	GeneRIF Biological Term Annotations	1.0	null
METTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09713
MYOG	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8005-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
EMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00894
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936582
TSPAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62487
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879916
M059K	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3327
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K85546819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42432
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93501
BRD-K76907295_VU0418947-2_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	1.0	null
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267874
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-SJXC-0126-SM-2XCFF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13327
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A_CA_04_2009_7dayMOI-10^5_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58549
GTEX-PLZ6-1326-SM-3NB24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884117
vorinostat-1645	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045706
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524764
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1815
synapse part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.068807
Developmental Biology	Reactome Pathways 2014	1.0	null
Perturb_17486_KO_Otub2_SRP314435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.30137
GBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59871
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33646
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25112
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51984
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11963
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.666809
VC-19-YG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277105
BRD-K20030272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10072
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.57402
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00411
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41909
trichostatin A-6454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
Nausea	CTD Gene-Disease Associations	1.0	1.30421
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.825193
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262103
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951058
PMC7617265-EMS137094-supplement-Supplementary_Tables.xlsx-ST12-eQTM_Gene_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
cefmetazole-6086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.22987
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77596
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951782
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07804
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.910735
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.33523
BRD-K44921931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90019
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82781769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1884
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSK3B_knockdown_206_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.81031
JB-75-NC66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311246
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.959
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5826
PATU8988S	DepMap CRISPR Gene Dependency	1.0	3.62135
1022_C19ORF53_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12554
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06473
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20036
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.586361
PMC12311512-mmc3.xlsx-OE_VS_NC2-Gene_Names_DR1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52310606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10744
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44921
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04216
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39079
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43889
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.552
trichostatin A-5572	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.06544
SVGp12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
BRD-K76609014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01754
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339075
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.33532
KLF4	ChEA Transcription Factor Targets	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.94161
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980797
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	176.105
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56357
hsa-miR-4664-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.837274
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10653
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164884_2_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EI-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12116
cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.616312
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47429
mantle zone of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16916
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989783
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	263.255
CRMPs in Sema3A signaling	Reactome Pathways 2024	1.0	null
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327854
bicuculline-2796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BF-10-IO69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269635
GTF2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22265
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Protozoan Infection_Intestinal Epithelium_GSE2077	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45071
hydroflumethiazide-7019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.246
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_7_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
PORCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619835
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
17880687-TableS1	GeneSigDB Published Gene Signatures	1.0	null
OVK18	CCLE Cell Line Gene CNV Profiles	1.0	1.45027
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45504
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20809
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-4083-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3499
BRD-K77273085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02692
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46707
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914688
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.974479
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53008
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52126
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54792
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
scriptaid-6919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99824630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08296
EZH2	ChEA Transcription Factor Targets	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15035
AM-38	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	2.00667
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.949207
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36149853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4226
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.622
MDST8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45733
BMI1-19503595-MEFC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stellate reticulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.068
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0437
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31806
OV56_OVARY	CCLE Cell Line Proteomics	1.0	14.6685
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TWIST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88418
18614019-TableS4d	GeneSigDB Published Gene Signatures	1.0	null
MTF2	ChEA Transcription Factor Targets	1.0	null
SLC10A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24207
SIN3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K36196444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12253
BRD-A46317335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01558
GSE151829,GSE151831_7_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32201
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29007
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-2268	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5642521-oncotarget-08-69847-s004.xls-Sheet1-List_of_down_regulated_genes_in_NRF2_KD_A549_cells_FC_1_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.07804
Mitochondrial Diseases	CTD Gene-Disease Associations	1.0	1.05349
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0967
nucleobase catabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.473
RSL24D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55011
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870101
RNF126	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11025
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33066
IL21_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2614
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11262
PPP2R5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22347
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909517
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.173165
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
betonicine-3745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
xylometazoline-7020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.898135
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retina	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1611
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-0226-SM-2I5FV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879304
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JAK2_knockdown_192_GSE54645	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.99286
WC-89-JT40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2761
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PQ-0626-SM-3NMCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02818
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
KP-N-RT-BM-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.39032
Poisoning	CTD Gene-Disease Associations	1.0	1.62246
IRF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11848
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fourth ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.295297
LS180_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.91481
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07968
KLF5-18264089-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-4770	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20756
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91803
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.31205
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.179
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23265
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04749
EGR1	ChEA Transcription Factor Targets	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73978
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832053
CTBP2	ENCODE Transcription Factor Targets	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.521465
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6213
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13031
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00632
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77275
ASPC1	DepMap CRISPR Gene Dependency	1.0	3.33438
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.15271
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149096_4_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.65358
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
Giant cell tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
A2058	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.13321
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30418
H3K9me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978859
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K64165176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56461
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32142
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18433
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05336
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.634
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16509
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
brain	GeneRIF Biological Term Annotations	1.0	null
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05137
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11462941-CAS-115-2947-s001.pdf-147-THAP9_THAP9	Rummagene Transcription Factor Associations 2026	1.0	null
7458_RPL30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.72866
mantle zone of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42023
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CXCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0043903
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875572
BRD-K23694339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18918
Perturb_6233_KO_Ugt8_SRP073495	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.85957
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834405
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06357
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85024
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-5128-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5109870-904	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal hippocampus pyramidal cell morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50435683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51587
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0344
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961396
autonomic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.715618
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32644
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.28341
Lung squamous cell carcinoma_LUSC_TCGA-34-5928-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59854
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72216066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05104
GTEX-T6MO-0526-SM-4DM6R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5612
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30586
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36278687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44324
NANOG-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10002
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238527
7511_RPS21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04195
BB65-RCC	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.34731
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1477
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499301
pyrimidine-containing compound catabolic process	GO Biological Process Annotations 2023	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.8545
r4 part of descending trigeminal sensory nucleus, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05657
Sarcoma_SARC_TCGA-HB-A3L4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52934
r3 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02746
trichostatin A-6972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AB-74-VK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248715
intermediate stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18459
Sarcoma	CTD Gene-Disease Associations	1.0	1.05648
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.312
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08112
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857781
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0283
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.166
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15893
BRD-K91577886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82342
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52405
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992936
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7439_RPL15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.13174
scriptaid-6901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
GTEX-NPJ7-1326-SM-3MJHO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866727
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-8_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04256
Axonal growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.3078
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.749579
RBBP8	MSigDB Cancer Gene Co-expression Modules	1.0	null
RPS4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60627
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K34028745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92445
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23907
Trophoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.172838
BRD-K65913831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86269
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.483
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661573
SOX2-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Mediodorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7055
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67893
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.72406
BRD-K44576681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48656
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GS-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal long term potentiation	MPO Gene-Phenotype Associations	1.0	null
Perturb_7865_KO_SDE2_SRP239880	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.78759
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59221664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0153
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ncoa_22072566_ly2_lof_human_gpl570_gds4095	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.207619
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Movement Disorders	CTD Gene-Disease Associations	1.0	1.01663
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932431
anterior paraventricular nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1969
caco2	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.507
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
GTEX-WFG7-1126-SM-4LMK3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71786
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cefotaxime-7186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.891506
GSE94011_2_v_1_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COX6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02392
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8547
7476_RPL6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.78238
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0935
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15963
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.523
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87691
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22318
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-27-MSX1_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
15744745-Table2a	GeneSigDB Published Gene Signatures	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K62555617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50728
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49332
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915866
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04296
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07531
Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040426
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.03084
PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal neuron morphology	MPO Gene-Phenotype Associations	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26129
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15635
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.763
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14025
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10193
hsa-miR-125a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17749779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02651
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08522
LS-123	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47342
KYSE-150	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48179
769-P	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94959
PMC7925689-41467_2021_21687_MOESM10_ESM.xlsx-A_HIF1A-Unnamed_8_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	1.0	1.34018
GTEX-WFG7-2426-SM-3GIL2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01176
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dpysl4	GeneRIF Biological Term Annotations	1.0	null
EMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0065
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K65725294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08879
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989427
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216243
3-Benzotriazol-propionic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3015_KD_SNHG1_SRP313438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.962522
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
nervous system development	GO Biological Process Annotations 2023	1.0	null
GSE154246_2_v_0_haspin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51774
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33569
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24984
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26293
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-TPRX1_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_TPRX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	1.0	1.34358
BRD-K18101567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21147
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K25844701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01502
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08215
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28360340_TW 37_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22492
LACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01559
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.66964
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050406
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16886
BRD-K29628221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01865
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.18159
4389_KIF23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.06207
Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valproic acid-6969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC45A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69662
cellular nitrogen compound catabolic process	GO Biological Process Annotations 2015	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.47941
6533_POLR1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.78571
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906007
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-2247	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3856
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K98451611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85148
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.13116
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.692144
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01124
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.06544
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40261
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20479
zalcitabine-7352	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_16_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-3868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K85525164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28592
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943271
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32649
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72837
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64425085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13004
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SRSF7_02_133	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.45943
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95294904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76112
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26518
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.882
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829728
RA-03-RQ19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349752
Secondary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50316
Retrosplenial area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27234
pyrimidine nucleobase catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2983_Mut_TP53_SRP287851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.0641
binding	GO Molecular Function Annotations 2015	1.0	null
pyrimidine-containing compound catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832121
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10209
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.917077
BRD-K93023309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44267
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.846602
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7255-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0554
BRD-K81795824_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998185
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41604
heterocycle catabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tooth germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315498
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66695
columnar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.529508
EEF1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47438
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.7768
mRNA_SALL4_19060217	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.853614
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91359
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062025
BRD-K12223973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40258
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S11-Table_S11_MR_resluts_of_brain_pQTL_and_any_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.974704
Perturb_10683_OE_hURI_SRP026667	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.0628
Perturb_13678_KD_DHX9_SRP018815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.2247
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.761008
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuron projection guidance	GO Biological Process Annotations 2015	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.46284
occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.321685
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52651
RAGE_knockout_267_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.43428
Down Syndrome	DisGeNET Gene-Disease Associations	1.0	null
KYSE30	CCLE Cell Line Gene CNV Profiles	1.0	1.93679
inner dental epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.886286
HCC70	DepMap CRISPR Gene Dependency	1.0	2.24149
BRD-K60905563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09586
proteins23	GeneRIF Biological Term Annotations	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10605
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.891896
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227056
Hepatitis	CTD Gene-Disease Associations	1.0	1.07269
Proteinuria	CTD Gene-Disease Associations	1.0	1.45723
GSE210580_3_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
NUFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13282
TUBB2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26306
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6839
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
YAPC	CCLE Cell Line Gene CNV Profiles	1.0	1.72591
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.949399
1771_COPB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34497
GTEX-QMRM-0626-SM-447BQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19114
BRD-K61431055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5759
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860131
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.15391
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1756
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873709
Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLXNA4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33698
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36676
GSK3B	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_7362_KD_KDM5A_SRP325972	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Retina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.667
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Tegmental reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0468
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46942
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7863-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.6582
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.49609
Quisinostat	DeepCoverMOA Drug Mechanisms of Action	1.0	2.1
ChIP_KLF4_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67961
Contractile vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.926
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82652
BRD-K08307026_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.916445
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.454698
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978859
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041706
trichostatin A-5441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pyrimidine-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7480_RPL8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.23908
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.3918
BRD-K61551681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00399
hsa-miR-3184	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335063
BRD-K18768055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22265
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
colchicine-3213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82399478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39321
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04491
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.973829
ameloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.478145
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23417
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	235.63
DMS-114	GDSC Cell Line Gene Expression Profiles	1.0	1.76699
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.654451
BRD-K32491833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20675
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56706
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892156
PC-18-VX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224701
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874398
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914854
r8 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49313
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SHISAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63327
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8820_TERF2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32555
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02046
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54554
MCAS	CCLE Cell Line Gene CNV Profiles	1.0	1.57199
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.56014
beclometasone-4580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
clorsulon-7025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
Limbic Encephalitis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K80239721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03873
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SLVL	DepMap CRISPR Gene Dependency	1.0	2.08276
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18908
BRD-K96096022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57437
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00546
MAFK_02_183	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.35755
RTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67511
APOBEC3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3924
SNU81	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22067
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07921
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29221
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.745441
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
diphenhydramine-6020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
U251	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.847209
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.6777
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1915
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Paragigantocellular reticular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64216
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.987483
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.887
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19951
SF539	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57246
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07145
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264556
REST	ENCODE Transcription Factor Targets	1.0	null
Perturb_4209_KO_Dmrt3/Dmrt5_SRP127681	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.50371
Secondary motor area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17065
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26124
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.13404
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10737
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
JHH-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.47627
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-0226-SM-4DXU8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966222
SH3GL2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
trichostatin A-2794	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872984
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
an3ca	HPA Cell Line Gene Expression Profiles	1.0	1.03697
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.33316
GTEX-PLZ6-0326-SM-3P61J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34375
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43543979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6778
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.917101
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.90921
Depression_Cerebral cortex_GSE12654	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.78894
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CREB1	ENCODE Transcription Factor Targets	1.0	null
GSE147535_2_v_0_lyz2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
isoxicam-7028	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AH-1226-SM-48TZL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27332
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
UNC93B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06379
BRD-K56437119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66047
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.38393
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.407
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.71501
GTEX-WEY5-1926-SM-3GIL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952587
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
related	GeneRIF Biological Term Annotations	1.0	null
TEAD4_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20523
Paragigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37523
DD-73-IP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374472
GTEX-O5YW-0526-SM-2YUMX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931454
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14248
PBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31073
NH6	CCLE Cell Line Gene Expression Profiles	1.0	2.221
TE15	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08976
A3KAW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65984
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.727
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26805
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11608
GSE213588_10_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.0494
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91006
9936_YJEFN3_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18394
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214936
nervous system development	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959894
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00059
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20209
BRD-K29711480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5532
Azotemia	CTD Gene-Disease Associations	1.0	1.03715
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844495
spiramycin-4319	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350074
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.831636
SUZ12-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.938704
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.953003
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-8121-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ACTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60119
trichostatin A-5625	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AF-12-IW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422507
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00989
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66110520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12701
RTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62458
trichostatin A-4072	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryonal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.476393
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263949
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.03175
WNT_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528739
EP300	ENCODE Transcription Factor Targets	1.0	null
LY-294002-5576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01537
Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_NANOG_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.981108
5279552-843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
7434_RPL12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39892
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911971
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
PMC8755441-mmc3.xlsx-IRF3-signif-Symbol_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
ZDBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62143
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98431828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00259
SIRT1_KO_GDS3666_295_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
VPRBP_KD_GDS4829_90_human_DU145 prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
ZBTB38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29242
CDKN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41053
BRD-K88936403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01252
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5893-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175883_0_v_1_dis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RELB_01_294	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.92453
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041465
NONO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01331
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879715
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88M-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23674
POLR2G_02_130	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.32193
Perturb_7518_KD_TRDMT1_SRP217219	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.3352
Mediodorsal nucleus of the thalamus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23795
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50643
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.58698
trichostatin A-7236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
SPINT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64265
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459034
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20028734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91848
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247662
hif2a_16565084_mcf7_lof_human_gpl2507_gds2761	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.309071
BRD-K54332342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05664
nucleobase metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15931098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00047
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.117878
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.928242
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53431
GSE100464,GSE100465_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KPNRTBM1	CCLE Cell Line Gene Expression Profiles	1.0	2.52827
7466_RPL36_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.36187
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22295
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11563
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.615317
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69796
4921_MDN1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07377
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08596
PMC12624014-41419_2025_7799_MOESM1_ESM.pdf-36-DOT1L_DOT1L	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24231
skin	HPA Tissue Protein Expression Profiles	-1.0	-1.06544
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33734659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00543
trichostatin A-3510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	1.40836
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58825
Hydantoinase/dihydropyrimidinase	InterPro Predicted Protein Domain Annotations	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2462
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7314-01A-31R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-2_E2F1-Gene_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134608,GSE134609_2_v_6_dlx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0741
SOX2-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
GTEX-XUW1-1126-SM-4BONZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05487
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03051
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.18279
BRD-K32862555_NCGC00183412-01_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78764
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.2208
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94892
Lung squamous cell carcinoma_LUSC_TCGA-77-8153-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59046641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53616
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.993251
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24322
7833_SF3A2_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31931
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29094
TJP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61827
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.82552
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855965
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
PRPF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9343
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.831598
1349_CCT5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16102
GULP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25546
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.407
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0975
r7 part of the basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25728
mRNA_RHOX6_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K91239327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78302
ERBB2_knockdown_232_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77721
Perturb_610_KO_SLFN11_SRP233181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.12867
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1184	CCLE Cell Line Gene Expression Profiles	1.0	1.97796
reduced long-term potentiation	MGI Mouse Phenotype Associations 2023	1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HHV8_72Hour-LEC_20080955_GSE16354	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.70359
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7717
valproic acid-1020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.35838
SNU626	DepMap CRISPR Gene Dependency	1.0	7.98026
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07818
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	1.73256
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CK-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6547
BRD-K37656403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24786
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.11401
KP-1N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ChIP_PRDM14_21183938	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
isocorydine-2780	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86531
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6024-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Foreskin fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01838
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
trichostatin A-1672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1921
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.47619
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r7 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25617
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.18025
PMC5787431__F2	PFOCR Pathway Figure Associations 2023	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31884
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.30353
MIA-PaCa-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43807
BRD-K96758498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54851
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.623
MDAMB415	CCLE Cell Line Gene CNV Profiles	1.0	1.98302
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29737
KNS81	DepMap CRISPR Gene Dependency	1.0	2.28611
BRD-K43981353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00782
Perturb_13409_KO_Zeb2_SRP066910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
trichostatin A-5065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Obesity	DisGeNET Gene-Disease Associations	1.0	null
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77976
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3706
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848237
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
habenula (old epithalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36511
Perturb_15818_KO_NRF2/PINK1_SRP343083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.70722
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040487
BRD-K92398088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00926
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_bone_marrow_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ZDHHC22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20164
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58136
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_18_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-646	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
endometrium_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.20261
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00063
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69338
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1255a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72887
SNU-C2B	GDSC Cell Line Gene Expression Profiles	-1.0	-2.09267
NCIH1993	DepMap CRISPR Gene Dependency	1.0	9.59448
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865948
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.397
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40228
Lung adenocarcinoma_LUAD_TCGA-97-7553-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72398
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23411
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330555
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.18915
Growth cone lamellipodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.734
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89259
POLR1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81553
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.978865
ID-70-SM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303825
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.64811
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
trichostatin A-6891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23942
hycanthone-5691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54712090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14587
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS-68 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903512
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10647
HIF1A_DEPLETION_GDS2760_642_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40177
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270991
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296396
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.166095
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0004
Prelimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39957
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54545
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.96304
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
7461_RPL34_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19503
TMED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08972
Rectum adenocarcinoma_READ_TCGA-DC-6156-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40544
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3B-Up_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27684
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314417
NANOG-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A491-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50272743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36803
Vorinostat	DeepCoverMOA Drug Mechanisms of Action	1.0	1.86
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33675
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.33909
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926924
BRD-K54351101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80748
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10678
ZFX_02_172	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6052
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76726
PMC9019027-42003_2022_3332_MOESM3_ESM.xls-Table_S1_HUVEC_MED23-KD_DEGs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.460129
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H526	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NA-16-OJ70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272954
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SART1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60364
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960143
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68083
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A204	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.02779
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1791
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03379
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20889
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.3712
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6517-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830486
ALOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454794
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957834
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28932578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36815
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290495
GTEX-PWCY-0426-SM-48TCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833374
hsa-miR-2861	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.127302
GTEX-PSDG-1326-SM-48TD2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932134
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45376
cellular process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11963
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063886
CC-84-JQ48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235512
BRD-K49472569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67044
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC16A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6208
trichostatin A-7550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.141
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.837992
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77452
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-04-AN21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448675
lateral part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41993
cyclocytidine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26863
SLC45A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70849
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49393
SUZ12	ENCODE Transcription Factor Targets	1.0	null
GSE211128_2_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4836-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ameloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.18915
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0698
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8534
HJURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12
XRCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04991
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCT116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45136
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Magnocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73887
chr10_132175614_C_T_b38	GTEx eQTL 2025	1.0	2.69385
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal hippocampus neuron morphology	MPO Gene-Phenotype Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4765-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40726
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64303
MDAMB453	DepMap CRISPR Gene Dependency	1.0	2.31393
hsa-miR-4722-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914854
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4958
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80661
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94888615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0142
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
BRD-K92991072_PAC 1_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87627
syndrome	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13354
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31347
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.928245
Kidney Neoplasms	CTD Gene-Disease Associations	1.0	1.06297
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MHH-NB-11	GDSC Cell Line Gene Expression Profiles	1.0	1.93548
KPNYN	CCLE Cell Line Gene Expression Profiles	1.0	1.38054
KLF2-18264089-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Calpain complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.574
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr10_132186626_C_T_b38	GTEx eQTL 2025	1.0	2.82336
SH-EP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
GSE226355,GSE226357_1_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26925
Autoimmune Diseases	CTD Gene-Disease Associations	1.0	1.36019
BRD-K51791049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.148
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982736
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2429
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57355
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.918032
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206401
Fatty Liver	CTD Gene-Disease Associations	1.0	1.60384
GSE238116_3_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBC1D24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27542
GSE158834_1_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
RMGI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38929
PLXNA2	Pathway Commons Protein-Protein Interactions	1.0	null
SP2509	DeepCoverMOA Drug Mechanisms of Action	1.0	1.08
SF3B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32694
GHDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04698
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.919229
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14666
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20644
TET2_KO_GDS4287_430_mouse_CMP - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.603284
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832575
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.325
BET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62185
NFIC	ENCODE Transcription Factor Targets	1.0	null
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05796
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18915
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
trichostatin A-6085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.732371
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZJ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27561
thioperamide-4675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PC-68-DU31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415387
LU99	CCLE Cell Line Gene CNV Profiles	1.0	2.34339
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205931
5190_MRGBP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39878
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62383
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC15	CCLE Cell Line Gene CNV Profiles	1.0	1.94215
cinchonine-2789	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMRC1	DepMap CRISPR Gene Dependency	1.0	2.07172
trichostatin A-6916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56343202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06535
SNU213	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78574
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.20066
BUD31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01085
BRD-K44415466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39933
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53396
GTEX-T6MN-1126-SM-4DM71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990217
5151277-903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K47337578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55461
BRD-K65315551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48953
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.885388
granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.890525
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4305_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.40683
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.234533
PMC6941881-mmc4.xlsx-IR_only_down_DEGs-List_of_DEGs_that_are_downregulated_upon_PRMT5_KD_only_in_IR_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25211
Retinitis Pigmentosa_Retina_GSE128	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.5372
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FOLD_CHANGE_1_5_RELB-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04599
BRD-K71554049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08156
BRD-K33953218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03066
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264585
BRD-K27864398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22657
HCC-33	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.24687
BRD-K83370434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03518
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.843972
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03895
GTEX-U4B1-0826-SM-4DXTW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49206
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833296
BRD-K35451051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0248
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48222
Fibrosis	CTD Gene-Disease Associations	1.0	1.47064
PTPRO	Pathway Commons Protein-Protein Interactions	1.0	null
trichostatin A-873	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99099
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	1.679
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958464
BRD-K00010082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00077
SLC35C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63704
pyrimidine nucleobase catabolic process	GO Biological Process Annotations 2025	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	4.95022
GSE134375_0_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982736
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.8098
BRD-K51207618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38711
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Distal axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.778
PANC-10-05	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46268
Inner dental epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.282
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.732204
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05832
Perturb_14846_KO_Zfp36l3_SRP055206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.62889
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223126
periventricular stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50604
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-1026-SM-43V6X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07962
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	187.693
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58286708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83454
KLF5	ChEA Transcription Factor Targets	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23115
LOUNH91	DepMap CRISPR Gene Dependency	1.0	3.16698
BRD-K57821544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90024
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3769
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.896013
Gigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24331
trichostatin A-2639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
flumetasone-3410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trichostatin A-7453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A56909893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70443
Venous Thrombosis	CTD Gene-Disease Associations	1.0	1.04051
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82092
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
pancuronium bromide-7329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06627
BRD-K69528787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20561
BRD-K56024445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52495
BRD-K73395020_ARP 101_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13038935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22952
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48213
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88156935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44911
BRD-K05465626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15634
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37288
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
18786252-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06305
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052595
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961423
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LU-139	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC5985538-mmc2.xlsx-Selected_2X_in_2_exp_SALL1_275-Gene_names_SALL1	Rummagene Transcription Factor Associations 2026	1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.635
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216933
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_17304_KO_Tug1_SRP176442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.81149
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.913
BRD-K85567359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03945
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09006
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924088
NCIH1573	DepMap CRISPR Gene Dependency	1.0	4.38219
SK-N-DZ	GDSC Cell Line Gene Expression Profiles	1.0	1.82689
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BT20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72324
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F9-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54384984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72581
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-IE-A4EH-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
18593951-TableS3	GeneSigDB Published Gene Signatures	1.0	null
PMC10828394-41698_2024_509_MOESM1_ESM.pdf-54-DPF1_DPF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961879
BRD-K87159315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09595
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5504_NCL_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01614
pyramidal cells of rostral CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885293
GTEX-OOBK-0625-SM-3LK5P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990367
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577801
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
streptomycin-7194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.862878
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.9741
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374393
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30932
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.9762
Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AN3CA	CCLE Cell Line Gene Expression Profiles	1.0	3.39306
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.960094
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271388
Auxin efflux carrier complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
19621087-Table1d	GeneSigDB Published Gene Signatures	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.978865
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70M-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3173-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22123421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13185
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04639
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.45054
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04725
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00377
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62855
FTSJ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01127
Brain Lower Grade Glioma_LGG_TCGA-DU-A76O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49I-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORVET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JZ-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954797
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02074
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266505
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7554
7441_RPL17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.90554
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040248
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.39401
HS2ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22264
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.91048
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13042
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30146
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.3454
BBOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00434129
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REL	JASPAR Predicted Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.530925
BRD-K80945184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54398
SH3GL3	Pathway Commons Protein-Protein Interactions	1.0	null
SOCS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.561
SRF	ENCODE Transcription Factor Targets	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57169040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04715
Anemia	CTD Gene-Disease Associations	1.0	1.23424
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872683
leflunomide-2539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ChIP_RNF2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-PLZ4-1626-SM-3P618	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978629
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913104
GTEX-PW2O-0426-SM-48TCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32796
Infertility, Female	CTD Gene-Disease Associations	1.0	1.2208
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5686-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5152487-896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869968
KMS21BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57304
growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.787817
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DPYSL2	Pathway Commons Protein-Protein Interactions	1.0	null
trichostatin A-3462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
vorinostat-5217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34465
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215508
rt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.90492
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9434
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-5017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Superior colliculus, sensory related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31198
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42637
CD-49-HJ53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280895
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59665
SNRPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45633
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40503
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11354
TGW	GDSC Cell Line Gene Expression Profiles	1.0	2.17112
BRD-A18825024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47497
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.344
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207933
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21329
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.855206
DKMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52221
DANG_PANCREAS	CCLE Cell Line Proteomics	1.0	2.39416
Fever	CTD Gene-Disease Associations	1.0	1.29657
HIF1A_NULL MUTATION_GDS1648_764_mouse_Hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_4360_KO_CEP83_SRP379856	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.42658
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.526546
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ED-91-LY45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380018
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897856
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61393
ChIP_NACC1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0809
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02211
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_4181_KO_Foxp1_SRP107214	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.70621
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.49023
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.3989
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9174_TOP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39464
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219047
MOLP8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47313
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97526
BRD-K61717269_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	GO Molecular Function Annotations 2015	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93409
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20337
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.889973
Paraventricular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13135
SKNDZ	CCLE Cell Line Gene Expression Profiles	1.0	1.67749
Metal-dependent hydrolase, composite domain	InterPro Predicted Protein Domain Annotations	1.0	null
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.13275
MOLT-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77355
CLCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45207
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.576087
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K25645002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02093
Brain Lower Grade Glioma_LGG_TCGA-R8-A6YH-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85765
GSE76425_1_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44432556_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93459372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58288
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NRP1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CW-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE108500_1_v_0_foxp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ADAM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69176
Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
r8 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63534
Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.81565
4960_MEF2A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07286
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0698
PMC9174260-41467_2022_30960_MOESM6_ESM.xlsx-S3-RAS2_unique_GATA2-Gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
ITGA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03701
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23437
Sarcoma_SARC_TCGA-IE-A4EJ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5555-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_NANOG_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949786
NCIH526	CCLE Cell Line Gene Expression Profiles	1.0	1.36369
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11343
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56973599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03405
RBBP5	ENCODE Transcription Factor Targets	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.02093
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922072
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370637
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27117
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924491
Perturb_616_KO_SLFN11_SRP233181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.89285
PLXNA1	Pathway Commons Protein-Protein Interactions	1.0	null
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2078
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60806
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16879
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.74569
BRD-K09117810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01407
BRD-K23533429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38945
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25254
intermediate stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49389
trichostatin A-4153	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.56205
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16884266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16638
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45673
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.966894
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088881
Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PKNOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96867
GSE109140_2_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10252
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95591068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23048
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45007
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.919809
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6914-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-4768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
BRD-K76755163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16325
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05551
pyrimidine nucleobase catabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lateral habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54621
QF-00-NO42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219348
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.854269
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866318
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.94171
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE80222_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31601
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.423
MFH-INO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53912
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23887
SMAD3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50119
BRD-K39020351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25142
PMC9046280-41467_2022_29963_MOESM5_ESM.xlsx-ASCL1_motif-Gene_Name_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.584
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086475
ARRDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0055
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.02635
intermediate stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00305
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06105
MTCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00299
dorsal part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36801
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0726-SM-4BRWF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11141
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981569
Site of polarized growth	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.97
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05077
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39603
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61579
5733_NOL11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.66484
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.84159
BRD-K34318928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23168
Perturb_2984_Mut_TP53_SRP287851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.63383
MIS18BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08338
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52959
PMC12826982-mmc5.xlsx-Table_S4-Supplementary_Table_S4_Differentially_Bound_Down-regulated_Peak-Related_Genes_in_Flag-SOX3-HSV-1_vs_Flag-SOX3-Mock_SOX3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13788250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11325
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549034
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17069664-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77259
organonitrogen compound catabolic process	GO Biological Process Annotations 2015	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26278
Parallel actin filament bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
A388	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K04886976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04488
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03434
NB(TU)1-10	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.25107
BRD-K05535086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26342
Thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842613
rhombomere 9	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20279
GTEX-XLM4-0226-SM-4AT4N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0963
MAFG_02_189	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.70044
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31221
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891015
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.833015
hsa-miR-339-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
9629_ATP5MD_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00613
reduced long term potentiation	MPO Gene-Phenotype Associations	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846545
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897856
abnormal hippocampus ca1 region morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-XGQ4-1826-SM-4AT6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860291
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD4_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14781_KO_Kansl2_SRP225948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.27886
JA-85-SW39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213551
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24937
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
G0S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82582
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NACC1	ChEA Transcription Factor Targets	1.0	null
SU8686	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265876
MAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50381
VU-0410183-2	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09197
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	277.102
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.55108
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430771
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.892006
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.12878
EIF3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24985
Perturb_16911_KO_Ezh2_SRP314053	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.15389
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41524
Brain Lower Grade Glioma_LGG_TCGA-CS-4943-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61416283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44686
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	0.862621
ZNF143	ENCODE Transcription Factor Targets	1.0	null
BC-84-BQ58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322204
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866318
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32454
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32956
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-8298-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44833533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30279
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A39193201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24984
GSE171401_1_v_2_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57535
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982736
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.78522
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25098
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
prostate	HPA Tissue Gene Expression Profiles	1.0	0.850109
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NANOG-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A896-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27404
7450_RPL23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.13994
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31976
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.931
GMPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66493
nes	HPA Cell Line Gene Expression Profiles	1.0	0.952803
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71106
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-1471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33775409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05593
aberrant	GeneRIF Biological Term Annotations	1.0	null
AE-14-NN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234206
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3888
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-2.33201
NCIH1975_LUNG	CCLE Cell Line Proteomics	1.0	3.58281
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6848-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70986
ERRFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33874
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Osteolysis_Leukocyte - Lymphocyte - B-Lymphocyte - Plasma Cell (MMHCC)_GSE755	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.78928
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.87727
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16568
Hyperplasia	CTD Gene-Disease Associations	1.0	1.17695
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30117
GTEX-WRHU-1326-SM-4E3K7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879748
BRD-K83916197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02478
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09255
pirenperone-4679	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06616
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_17_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235550_1_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73051782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3375
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488018
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.286983
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.858046
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MLST8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77196
BRD-K77892726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22546
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06318
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49573242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14998
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
DMS153	CCLE Cell Line Gene Expression Profiles	1.0	1.34727
NB4	DepMap CRISPR Gene Dependency	1.0	3.82334
r8 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55406
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4881-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08766
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908899
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01669
1828_CPEB1_ENST00000568128.1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04915
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	0.894141
Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4P3-0326-SM-4AD6P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34092
BRD-K61438422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3008
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Oculodentodigital dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
5748_NOP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.30888
7438_RPL14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.74226
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19402
parathyroid gland	HPA Tissue Protein Expression Profiles	1.0	0.978865
Secondary enamel knot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.316
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38668
SUV39H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55038
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00269
visual cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412011
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03336
Auditory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.35191
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16632
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32434600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67849
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13432
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96637144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05448
km3	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
Perineurium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33865
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61998
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.949714
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61032
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19163
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
PIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20218
trichostatin A-5903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_14436_OE_Cyp17_SRP340317	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.90335
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7453_RPL26_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42852
CB-30-KN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211175
SLC1A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23566
rhombomere 8	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25166
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16337
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K76812105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23776
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16008
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03366
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0824
kidney_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.909713
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932431
NCI-H1648	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.5713
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6928
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Prostate adenocarcinoma_PRAD_TCGA-HC-7077-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74251295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20931
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08081
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HOXD4_HOXD4	Rummagene Transcription Factor Associations 2026	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3204
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32757
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8576
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21876
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906043
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PPARG	ChEA Transcription Factor Targets	1.0	null
Axon guidance mediated by semaphorins	PANTHER Pathways	1.0	null
BRD-K97576000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71362
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.63044
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914505
9682_UTP15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4325
chr10_132197789_G_T_b38	GTEx eQTL 2025	1.0	5.87925
Anterior cingulate area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50625
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75543
DUSP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04034
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94797
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_14_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Oral apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.609
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174058
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.623351
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11953091-12035_2025_4695_MOESM1_ESM.xlsx-s5-Supplementary_Table_5_Results_of_the_2-sample_pQTL_MR_on_insomnia_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4098
FAM171A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69833
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.9032
enoxacin-4655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318883
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE175683_3_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.3031
ChIP_NANOG_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38856
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281482
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87053028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10772
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09681
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828536
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.979832
STX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08879
Main olfactory bulb, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30848
Brain Diseases	CTD Gene-Disease Associations	1.0	1.31416
dna	GeneRIF Biological Term Annotations	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11356
BMS 303141	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
OB mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07549
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
trichostatin A-4710	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02746
GTEX-U3ZN-1626-SM-4DXTZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67958
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062923
intermediate part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32682
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33295
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_7_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PRELID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.08686
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
chr10_132196539_G_A_b38	GTEx eQTL 2025	1.0	5.25966
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01619
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299779
nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.244962
mantle zone of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32663
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086552
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47126
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04566
SIMA	CCLE Cell Line Gene Expression Profiles	1.0	1.90647
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59457
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lateral habenular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60218
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1477
MYC	ENCODE Transcription Factor Targets	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-SIU7-1126-SM-2XCDW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882199
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00241
JHUEM2	CCLE Cell Line Gene Expression Profiles	1.0	1.46117
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.14713
BRD-K36445086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01884
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAS-1	GDSC Cell Line Gene Expression Profiles	1.0	1.92924
BRD-K87654551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80312
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36191
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83034
NACC1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
trichostatin A-6551	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53443165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35515
SJSA-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
protein binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K79887735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34885
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03318
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
Retina	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LANCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55063
DC-84-CJ21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436435
Tooth germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.971
hsa-miR-4319	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.487886
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335167
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
C32	CCLE Cell Line Gene Expression Profiles	1.0	1.38285
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5855
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13922961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14886
medial part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17128
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
REST_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94292
Learning Disorders	CTD Gene-Disease Associations	1.0	1.7418
AP3S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00098
NFE2L2_KO_GDS514_699_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70427
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1301_CCDC86_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29861
estradiol-6957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
moracizine-6000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2790-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS578T	CCLE Cell Line Gene Expression Profiles	1.0	1.78809
USF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20484
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19314
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216421
ZNF384_02_203	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63743
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05946
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01885
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964419
CEP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94155
HEC50B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51876
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060804
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.621714
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43712
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13I-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376146
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.657
COGN305	DepMap CRISPR Gene Dependency	1.0	3.55382
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302146
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970269
SIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11525
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.66757
rectum	HPA Tissue Protein Expression Profiles	1.0	0.978865
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18494
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15569
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08001
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041585
ES4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Mediodorsal nucleus of the thalamus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7055
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.835169
BRD-K95323025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52471
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04142
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.751
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44253
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10465
Retrosplenial area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1956
TOV21G	CCLE Cell Line Gene CNV Profiles	1.0	1.52015
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11823
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35652
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5664
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-6064	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	0.978865
BRD-K47707657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83739
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78363521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04914
BRD-K16276539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02204
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51018
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
EZH2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K44828787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93014
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13683
Diarrhea	CTD Gene-Disease Associations	1.0	1.08091
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33443
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41106
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06605
NCIH146	CCLE Cell Line Gene Expression Profiles	1.0	1.59971
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71486304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_1W_vs_LS_1W-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2972
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01663
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.694
oligodendrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.62991
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5494-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Huntington's Disease_CNS - Brain - Cerebellum (MMHCC)_GSE3248	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.09572
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.5093
PMC6487024-13148_2019_658_MOESM2_ESM.xlsx-S10-Pr_intrc_ADNP-1-Unnamed_1_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
2105_DDX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.78506
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-27-ENSG00000163132_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74963702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04381
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05183
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27643
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85326
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7503_RPS15A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37584
rostromedial tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07659
CL1-0 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
trichostatin A-1072	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-661	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K27723822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77068
18310659-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145323,GSE145324_1_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
trichostatin A-7407	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37863
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98571
20860821-TableS5	GeneSigDB Published Gene Signatures	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55795
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407624
JUN	ENCODE Transcription Factor Targets	1.0	null
BRD-K74378303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06298
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14043
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1435	CCLE Cell Line Gene CNV Profiles	1.0	1.84083
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859491
AMPK gamma-3_KO_GDS1938_163_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04636
DPYSL complex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
PTHrP_KD_GDS1664_438_human_MDA-MB-231	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K42987166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9614
Lung squamous cell carcinoma_LUSC_TCGA-22-5485-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.788791
estradiol_homo sapiens_gpl6947_gse27375	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2919-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypoglossal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
BRD-K34297711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13594
trichostatin A-981	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Muscle Weakness	CTD Gene-Disease Associations	1.0	1.01587
intermediate stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43115
r8 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6494
diclofenac-2756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63996931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34668
Perturb_4413_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Choreatic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1263
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13607
Perturb_15223_KD_FOXC1_SRP276213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.9316
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76829
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370928
ZR75_1	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.917354
CBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38413
trichostatin A-1535	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.078524
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11925
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85281
TP53_01_38	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.15
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.02339
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
PTBP1_02_07	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62149
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ECHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28919
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60627
BRD-K93990956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07399
Semaphorin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IGFBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82788
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.323874
8605_SURF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4374
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI8226	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97363
colon_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.82627
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07972
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20923
lateral part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51324
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436874
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.978865
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6870-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951421
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_downregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04457
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62985
Axon guidance	Reactome Pathways 2024	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00197
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12959
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TYK-NU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03233
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73084
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-5336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC_Activation - 21 days_GDS2025_727_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.92751
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.79491
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
r2 part of prepontine raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06363
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876913
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20468
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66641
293n3s	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.271
NANOG-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC10679662-mmc2.xlsx-NC-D3-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.936622
Growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.992
chr10_132187458_G_A_b38	GTEx eQTL 2025	1.0	1.47227
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7828
oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.596862
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.5
Pauciarticular juvenile arthritis_Peripheral blood mononuclear cell_GSE1402	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.72531
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
KDM4A	ENCODE Transcription Factor Targets	1.0	null
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86444
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45273
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A703-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.503
Main olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27983
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41861
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A84923154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13341
9974_ZBTB17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0626
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.346
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
NR0B1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A_48H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24863
toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.196139
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830644
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40356
CGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37626
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13757
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00198
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042294
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4823-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36289678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65663
trichostatin A-4344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56822
COLO775	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83197
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.26423
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.77774
BRD-K41504921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12058
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEW-1326-SM-4AT63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34118
BRD-K83715372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02759
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Nutlin3a	DeepCoverMOA Drug Mechanisms of Action	1.0	1.02
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54205
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.831129
Caspase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.539
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050774
BRD-K84601599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01388
PSAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04956
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114553_0_v_1_lhx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
separase-securin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
BRD-K01452910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45561
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-68-7755-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vorinostat-1000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
ceftazidime-1721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849789
superficial gray layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09968
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.815233
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.22019
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13135
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943287
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10144
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16185
ChIP_SOX2_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_12630_KD_SIRT5_SRP311327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
impaired synaptic plasticity	MPO Gene-Phenotype Associations	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77102
FYN	Pathway Commons Protein-Protein Interactions	1.0	null
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60603
CDC25B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23738
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_9_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72842
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.86066
KLF4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908078
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902262
nucleobase catabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K16279128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3708
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLXNA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833742
SNB19	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.71403
BRD-K04426746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11728
ambroxol-5319	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64001
RNF2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19505326-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55474
SHSY5Y	CCLE Cell Line Gene Expression Profiles	1.0	1.61069
GSE174406_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_15_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS12BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86227
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936712
AN3-CA	GDSC Cell Line Gene Expression Profiles	1.0	2.02008
KLF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500503
MJ	DepMap CRISPR Gene Dependency	1.0	3.72855
NR0B1	ChEA Transcription Factor Targets	1.0	null
7729_SDR39U1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17275
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44122
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06372
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02275
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36347
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358613
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59093
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.9715
18387200-Genes	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02381
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53384
SNU478	DepMap CRISPR Gene Dependency	1.0	2.99697
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2823
astrocytes	BioGPS Cell Line Gene Expression Profiles	1.0	1.20792
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06033
GSE180525,GSE180528_2_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pruritus	CTD Gene-Disease Associations	1.0	1.10246
Perturb_1060_Mut_Esr1_SRP087718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.7168
1483_CENPJ_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17232
EFR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04844
abnormal hippocampus CA1 region morphology	MGI Mouse Phenotype Associations 2023	1.0	null
LU-99A	COSMIC Cell Line Gene CNV Profiles	1.0	2.15316
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.95209
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HS578T	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977277
Amidohydrolase 1	InterPro Predicted Protein Domain Annotations	1.0	null
hsa-miR-3937	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08793
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25278
BRD-K44908610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83961
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Stratum lucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
GTEX-QMRM-0826-SM-3NB33	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71879
BRD-K54769228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47134
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02049
BRD-K12077693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52604
7471_RPL39_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.65706
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
levomepromazine-7399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943256
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974484
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.43782
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04075
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TE441T	CCLE Cell Line Gene Expression Profiles	1.0	1.66291
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832053
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
trichostatin A-7047	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11117868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02798
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00981
CRYZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0436
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_19_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98313
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55682
loperamide-4672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03192
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-WFON-0826-SM-4LVMI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56682
Dermatofibroma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
SPTLC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30836
nucleobase catabolic process	GO Biological Process Annotations 2023	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48115
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17383
thiamine-responsive megaloblastic anemia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
LY-294002-996	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913588
abnormal brain morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K74506886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43663
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12495274-mmc1.pdf-44-LHX9_LHX9	Rummagene Transcription Factor Associations 2026	1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	4.25304
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075479
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-1.05471
SNU1272	CCLE Cell Line Gene CNV Profiles	1.0	1.71654
abnormal cns synaptic transmission	MPO Gene-Phenotype Associations	1.0	null
outer SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06894
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00998
BRD-K02395808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81562
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TARDBP_02_129	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.39232
PMC6411037-NIHMS981149-supplement-4.xlsx-Table_S3E-Table_S3E_Result_of_GSEA_with_human_ST-EPN-RELA_gene_set_DEGs_in_PDGFA_tumors_relative_to_RELA_fusion_tumors_are_listed_in_the_table_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964813
Semaphorin interactions	Reactome Pathways 2024	1.0	null
7422_RPAP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06264
901_BRIX1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04658
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
F36P	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4187
BRD-A51777634_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
metyrapone-5667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6464-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.74993
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860912
hypoglossal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.849165
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO684	CCLE Cell Line Gene Expression Profiles	1.0	1.60498
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RXRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29298
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.949954
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15426_OE_TRIB1_SRP176423	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18834
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03562091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20297
UBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50443
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04296
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29863
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14217
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9697
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03133
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.91874
Lung adenocarcinoma_LUAD_TCGA-MP-A4T7-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28634
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865856
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
periventricular stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39225
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84953
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7193
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26553
HCC33	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.750405
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824099
mantle zone of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5962
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06511
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56053
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anemia, Aplastic	CTD Gene-Disease Associations	1.0	1.0869
RPUSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66019
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55529
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61853
SNU398	CCLE Cell Line Gene CNV Profiles	1.0	1.49883
Axon guidance	Reactome Pathways 2014	1.0	null
21220101-FigureS6	GeneSigDB Published Gene Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07878
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16628
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09795
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.568628
trichostatin A-3243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1758
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83485
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27536
trichostatin A-5308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.48017
BRD-K82837433_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
conivaptan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237987
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.3399
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08098
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-34a	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.530438
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.38641
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892682
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
IB-33-TE51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383118
BB-42-FF52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230897
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062363
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09964
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434851
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927897
NCIH209	CCLE Cell Line Gene Expression Profiles	1.0	1.42483
SNU668	CCLE Cell Line Gene CNV Profiles	1.0	2.12523
Lung squamous cell carcinoma_LUSC_TCGA-33-4532-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.13449
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.43892
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12385
YWHAB	Hub Proteins Protein-Protein Interactions	1.0	null
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874565
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST-18959480-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951298
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33058
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E0-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.960797
MXI1	ENCODE Transcription Factor Targets	1.0	null
Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.17848
BRD-K68595406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27357
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19964
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15117
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09969
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978029
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.994458
e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.48607
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1685
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3445-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89442
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06683
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.71902
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.657851
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18087940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25822
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836622
BRD-K58129723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17891
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0431
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04323
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7834_SF3A3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10194
5738_NOL9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06652
BRD-K44224150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42022
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	1.11091
heart	GTEx Tissue Gene Expression Profiles	1.0	1.16858
Perturb_8654_KO_ESRRA/ESRRG_SRP304242	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BT16	DepMap CRISPR Gene Dependency	1.0	2.24386
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.65145
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.20372
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888368
abnormal hippocampus pyramidal cell layer	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_261_KD_PBRM1_SRP358304	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KYSE30	DepMap CRISPR Gene Dependency	1.0	3.38078
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200243
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055873
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850456
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.262
PMC7608835-aba3058_Table_S5.xlsx-RING1B_EWS-FLI1_ACTIVATED-RING1B_EWSR1-FLI1_activated_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
JSC-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.68299
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35173
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01084
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55628
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00013
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00524
PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_B_BNC1	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76677
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09776
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58492
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitotic spindle midzone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.875
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27652
Heart Diseases	CTD Gene-Disease Associations	1.0	1.29103
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03127
mantle zone of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51241
7527_RPS5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50877
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03492
BRD-K63800697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08566
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1711
KPNYN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48087
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.531
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-34c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NB(TU)1-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
terminal bouton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250389
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14241
enamel organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.375368
Brain Lower Grade Glioma_LGG_TCGA-E1-5304-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0818
EZH2	ENCODE Transcription Factor Targets	1.0	null
BRD-K85977749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90842
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57499
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	GO Molecular Function Annotations 2025	1.0	null
PMC12555112-Supplementary_Data.pdf-15-ZNF16_ZNF16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04959
HCC-44	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PRSS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20176
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.1588
7522_RPS2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1549
BRD-K65445351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82462
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QVUS-0626-SM-447CC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952942
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21254
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77436
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66795
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.324
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV31-0326-SM-447BM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18403
Arteriosclerosis	CTD Gene-Disease Associations	1.0	1.12495
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
WAOSEL	DepMap CRISPR Gene Dependency	1.0	2.00207
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.19758
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.80887
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.902701
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87566
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84848
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19645
H-EMC-SS	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.77871
7509_RPS19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.31717
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Stratum intermedium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.14
Neoplasms	CTD Gene-Disease Associations	1.0	1.24338
17880687-TableS5	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31936306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19698
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055334
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mesopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
GEM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39144
BRD-K90103010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31252
GSE138818_1_v_3_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
REST-18959480-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
trichostatin A-5976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K74918080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20946
CAL-54	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77353
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832053
Prostate adenocarcinoma_PRAD_TCGA-VN-A88L-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Seizures	CTD Gene-Disease Associations	1.0	1.08833
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999618
BRD-K90951880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21771
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K05041614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24066
Oligospermia	CTD Gene-Disease Associations	1.0	1.61529
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP-N-YS	GDSC Cell Line Gene Expression Profiles	1.0	1.63938
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null