association	dataset	threshold value	standardized value
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2246
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.7697
Katanin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.917
NFATC2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56375
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80874
PMC8044433-mmc4.xlsx-Sheet1-Acute_LPS_Microglia_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DDIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36933
Outer dynein arm docking complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.546
KIF1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15866
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXJ3_FOXJ3	Rummagene Transcription Factor Associations 2026	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.7356
CCT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29895
LIPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02675
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10104
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Manchette	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.268
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9274
496100480_HIP_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.53335
PAX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16391
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
LRPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23569
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
METTL25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43681
GSE240258_0_v_1_prmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4681
Bardet-Biedl syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
TRAFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34273
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C9orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15602
PA2G4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07652
TAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29306
SLC52A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.06141
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6117
ED-31-AA47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.595638
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7631
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
AGPAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50836
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Septin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.785
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12075
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ciliary vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61736
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1454
Cauda epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.602
C6orf141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74672
POLR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7805
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.456
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8624
LUC7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.122
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08215
NOP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82855
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.85381
TSEN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69025
Outer dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.913
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14956
9+0 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.582
LRRC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73517
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1594
RAPGEFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52986
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6086
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75522
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07245
ZNF737	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92852
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoplasmic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.677
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9993
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ING3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94745
PARP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8285
s117	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.603
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.87092
HSPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32775
APBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25344
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary cap	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.311
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.751
SMCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92338
Right atrial isomerism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
Spermatozoon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.267
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92482
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8058
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.502
WRAP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67093
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.52202
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63305
NDUFS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0298
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF5AL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60724
GSE210885_3_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8355
PRIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82182
PSMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61534
ESPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49004
SCAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20757
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7795
RCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20589
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72022
TAS2R5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88722
SEMA3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44718
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15163
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1724
PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_AsPC1-Nearest_Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34554
GSE156115_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55404
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27015
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SLC16A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16747
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5188
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.01
DHPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17742
ZNF860	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07978
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11045
DHRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35349
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03247
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary rootlet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SAGA-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.179
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33139
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0524
ZIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01984
Annuli extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.897
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8333
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6077
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34562
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45307
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50924
GSE188870,GSE188871_1_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77441
GSE140200_2_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5872
CRCGN017_MCF10A.WT.HP_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14231
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34365
AASDHPPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42178
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8656
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31799
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34184
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57051
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43957
PTPN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35036
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.5931
ZFP69B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1582
Otitis media	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
DSEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28092
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45432
CORO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55715
EIF3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55363
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31829
PRDM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75604
DPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56941
GBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01794
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ELK3_ELK3	Rummagene Transcription Factor Associations 2026	1.0	null
Sperm flagellum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88951
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40751
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24526
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.6672
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14288
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
496100372_HIP_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34386
NR1H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20108
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Inner dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.026
MFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96321
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
LRRC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35512
RFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92393
ZFP64	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34184
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0155
Cell septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.609
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12661646-dmm-18-052290-TableS8.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8339
TMEM191C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52781
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2736
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.089
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8303
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18147
LRRC8D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43495
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2208
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0593
ARL5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39783
Hsf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11395
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
HNRNPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33537
PMC12661646-dmm-18-052290-TableS9.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46681
CRCGN016_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20184
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0088
TPCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.185
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
DRAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63368
Chromosome 2q37 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8217
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18502
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.422
TM9SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21421
cilium	GO Cellular Component Annotations 2025	1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7645
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88779
OSBPL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00918
GSE128076_2_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.2971
Intraciliary transport particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VAMP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28897
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rootlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
RANBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80757
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46896
YIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40583
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22713
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CLPSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61877
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Nose disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MNT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5617
Waist-hip index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Ciliary shaft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
CPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09701
FAM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72398
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.2044
9+2 motile cilium	GO Cellular Component Annotations 2025	1.0	null
PRDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25571
Axonemal outer doublet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.862
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.426
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59639
SLC45A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20552
SEC63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94623
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
TNNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49116
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92138
SIPA1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08154
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25335
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPATA2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18249
Coronary artery disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
FAM222B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47419
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.0011
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1661
LARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45171
SLIK (SAGA-like) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.546
Motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.989
CPSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25078
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16667
PMC4141782-pone.0105522.s006.xls-NFATC3-Unnamed_1_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.6774
COQ9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29454
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7137
GSE102598_1_v_2_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95518
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
UTP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.012
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.617
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.5559
TUBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13382
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.061
MREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80848
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-Metabric_Sparse_KM_976-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
UGP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12118
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9932
CCND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52206
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NUP214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38092
ZNF221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38987
UQCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12695
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S100A16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30154
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
MAP7D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0673
RAD9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27453
Situs inversus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
Ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.456
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SAMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79697
PREPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4406
Charcot-Marie-Tooth disease type 1A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
URM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04559
CRCGN011_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0022
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63919
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.108
S0-EE-XNAL_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20492
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36725
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
RBM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77608
CRCGN015_MCF10A.TP53.M_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17595
Mature stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0217
MKKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25097
MOCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43707
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
Metabolic dysfunction-associated steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.41595
ELL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2628
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.6681
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE2Q2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10969
Cytoplasmic region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE154961,GSE154963_4_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SERPING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03341
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.972
GART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32471
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.814
TRIM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39102
CD2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13047
RPL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73105
CRCGN011_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3304
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
GATA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28351
CHMP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55008
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.5923
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82734
NOL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2754
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11505
RBM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94831
RPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66306
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9243
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.54275
ZBTB49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32947
Acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
AP1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20651
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
DA-33-IZ67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.523422
HNRNPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38489
496100294_HIP_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22146
PMC12661646-dmm-18-052290-TableS7.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Lumbar spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.168
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Axonemal central pair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
Trachea	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RNF215	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90538
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3801
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARL8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21627
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4563
CPSF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39563
ZNFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19589
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
ADAMTS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74245
ARFGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10512
ANOS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25881
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35418
Axonemal dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.806
KAT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.02246
COA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87957
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC43A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38521
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2409
CRCGN015_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0508
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49423
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF841	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82788
HNRNPA2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18439
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1332
PCBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16224
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13095
Ciliary membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
Psmb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.438
496100388_HIP_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53667
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.4877
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4455
9+2 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.98
OXNAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43967
Sinusitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
ITPKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39955
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
HIR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.827
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2454
sperm flagellum	GO Cellular Component Annotations 2025	1.0	null
Craniometaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
Anterior commissure	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
Sperm flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.233
RAMAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26649
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63717
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2986
Radial spoke head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.632
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28115
STAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55882
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6927
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2251
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TOR1AIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25874
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RAB40C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24398
ATG14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1745
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68672
NR5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.47136
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.901
Intraciliary transport particle A	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.122
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77459
Y-shaped link	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54101
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Outer dense fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.507
MRPL45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.95001
RBM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46152
GSE86507,GSE86509_3_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SLC35A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44162
l35	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34958
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24465
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	9.0061
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9421
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Axonemal central apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.244
CRCGN015_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3867
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.07622
GSE222500,GSE222501_1_v_0_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACAD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03574
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
Vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.7854
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Reading disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
SEC14L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19325
Axonemal microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.682
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12275
PCDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00961
Smad4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.757
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32762
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sperm head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.034
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.316
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4196
ZDHHC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03509
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
GTEx Heart 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-8.89418
Tracheal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.219
9+2 motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.51085
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CIDEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46264
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAP3K14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46558
FBXO28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2558
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.751
Kenny-Caffey syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
WHRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99069
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.339
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CSPG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01293
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55097
TBRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44643
NXPE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30472
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.30233
CRCGN016_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24371
Waist circumference adjusted for body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.6265
Smith-Magenis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.09
SKIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31651
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9033
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4786
Lysosomal storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
TADA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26973
CHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43074
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33024
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3007
TYW5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10133
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.4127
PIK3C2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50242
SMIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18389
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68596
Waist-to-hip ratio adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.930103
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.2749
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
MANSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00812
APPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82387
PPP4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05833
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.1894
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77196
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ciliary plasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Intramolecular phosphotransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.026
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.996
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.711
Axoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.05
NUTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23342
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
SLC2A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64662
Myocardial infarction	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
TSC22D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52783
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3675
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-AsPC1_KLF5_activated_H3K27ac_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03541
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-encode-consensu_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
RING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61569
Lipid storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
MIER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35569
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20741
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cortical layer of collagen and cuticulin-based cuticle extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.897
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9664
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100671_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.72806
DLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.11717
Charcot-Marie-Tooth disease type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
TDRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94854
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
TMBIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69329
TRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13194
IGFBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03973
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Cytoplasmic microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
STX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71861
VIPAS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30656
Hyperphosphatasia with impaired intellectual development syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
DCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90521
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.5076
Artery disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
TBCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77542
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61323
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.2936
LAMTOR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5642
MPV17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37317
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70716
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.751
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17251
HDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52891
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLCCI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40894
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
C17orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39327
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26321
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KRI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15389
Sperm flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.08
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.1431
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.60708
MAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25607
PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_2_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
RGPD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56549
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3389
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47003
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2226
STAT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13654
HOMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53684
CWC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14796
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9375
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.251
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
AP3S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9643
USP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29302
RLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55566
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SART1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7607
HERPUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25873
Middle ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
FERD3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23206
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.789
CCDC61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90336
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00005
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.664
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20539
Intraciliary transport particle B	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
MIER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56844
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF790	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31933
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Collagen and cuticulin-based cuticle extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
Cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.85
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	342.436
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15312
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01754
Visceral heterotaxy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32051
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
C3orf80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12223
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9834
SPDEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16375
BA-66-BL56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224435
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.517
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PADI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40118
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CDK2AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48942
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40307
CENPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62373
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
SRP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41333
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
KBTBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65355
PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.91847
TUFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51092
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MED24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27873
CRCGN011_HEPG2_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.206
ANGEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56338
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.3392
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TAFAZZIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07956
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SPATS2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29273
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2972
PMC4467436-oncotarget-06-6267-s002.xlsx-140527_cd44Cutoff_txt-PAX6-M_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.692
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41605
TGIF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10113
Auditory capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24628
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202628
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7458
Primary ciliary dyskinesia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.04
CLCN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26183
Palatine uvula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99675
GALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13094
CRCGN017_MCF10A.TP53.M_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1644
ANAPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20126
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.469
496100433_HIP_probable Alzheimer's disease_TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12884
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58515
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22519
TMEM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37366
WBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80491
GSE195568_2_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.75205
chr17_17972697_A_G_b38	GTEx eQTL 2025	1.0	2.57135
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.0466
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.555
PMC3023804-pone.0016344.s008.xls-S3_High_Confidence_PPAR_Peaks-Primary_Gene_ID_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.168
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08155
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
COX6B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15321
HELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53669
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49547
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0192
MED27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70863
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NSUN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.777
COX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24052
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RASA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94826
DPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7036
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7479
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9756
Ciliary plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.05
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2611
ZFP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26981
MRPL43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06962
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
MRTFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32766
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IER5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66352
JAK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9371
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
ECT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3968
Axoneme	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC12661646-dmm-18-052290-TableS6.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6258
TMED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05903
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31985
ACAD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29374
UBE2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33165
Potocki-Lupski syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.712
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6012
LCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34664
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.4587
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60592
GPR153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82721
LDAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24833
CENPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09777
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50315
Deuterosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
CRCGN014_HEPG2_3H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14106
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21975
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48865
PLA2G4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23469
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18436
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Radial spoke stalk	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.412
SNRPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17661
Dyslexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7699
Chronic purulent otitis media	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8815
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1023
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MTHFD1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69258
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2279
CRCGN016_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1258
GSE202744_1_v_0_toyocamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZSWIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41537
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.582
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68595
MRPL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26972
TMEM243	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69898
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
RPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07444
Paranasal sinus disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43024
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13919
GSE200673,GSE200691_2_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
PNKP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59046
PTGES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16037
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1368
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90635
SDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79693
PDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25968
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100464_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06728
GOLM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0827
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14287
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
HBEGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39421
RBM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3714
Phosphomannomutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.027
NDUFAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91648
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72591
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
ACBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00683
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.8785
Ependymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.476
PMC3023804-pone.0016344.s008.xls-S3_High_Confidence_PPAR_Peaks-Primary_Gene_Name_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
METTL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36771
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6873
ATP13A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72391
GSE83145_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LRSAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98469
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48772
OSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37936
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8706
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1814
LRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41808
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42045
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
JADE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4205
RBM38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32681
RPS6KL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96463
LYRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35075
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ISL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42698
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.49477
MAML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18939
PMC12661646-dmm-18-052290-TableS5.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
MEF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25857
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Phragmoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.768
Ciliary base	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.168
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08335
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEP152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09932
CRCGN009_HEPG2_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23847
Middle ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PODXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36712
Dynein axonemal particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.024
RAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57031
Pyrenoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.315
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2735
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1491
TMEM234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9067
retromer, cargo-selective complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4544
CRCGN015_HEPG2_48H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02829
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1153
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_41_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
WDR81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74198
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.751
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0182
Radial spoke	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.026
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.177
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81113
CTR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46435
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.22957
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GOLGA6L9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10916
POLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14542
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.96443
TKFC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00459
TMED8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43746
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ciliopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
PAQR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41274
CSTF2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05404
MCM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17309
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.49676
HEXIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56813
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null