association dataset threshold value standardized value FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null OVCAR-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.884 Intracellular anatomical structure COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.754045 FOXJ2::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.7837 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6942-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null BRD-K64904523 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35259 BRD-K30910725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37225 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24509 SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49592 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.911659 Lung adenocarcinoma_LUAD_TCGA-55-8206-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061248 BRD-K46715415 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03095 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43045 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.40998 APP Pathway Commons Protein-Protein Interactions 1.0 null BRD-K47349225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9858 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39008 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06951 CHD1 ENCODE Transcription Factor Targets 1.0 null CRCGN013_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44112 CRCGN015_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48784 Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.2764 BRD-K99127896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0975 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6389 regulation of cellular process GO Biological Process Annotations 2015 1.0 null BRD-A85231803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39506 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.18039 MUTZ5 CCLE Cell Line Gene CNV Profiles -1.0 -2.00401 CRCGN013_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9042 DANG CCLE Cell Line Gene CNV Profiles -1.0 -1.33368 BRD-K19712135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2715 PSS008 DepMap CRISPR Gene Dependency 1.0 2.45901 negative regulation of protein metabolic process GO Biological Process Annotations 2015 1.0 null A3KAW CCLE Cell Line Gene Expression Profiles 1.0 1.37501 NCIH1651 CCLE Cell Line Gene CNV Profiles 1.0 1.4152 hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.408292 BRD-K05753543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36627 BRD-K14375790 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7156 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null ICC10 DepMap CRISPR Gene Dependency 1.0 2.17074 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4098-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.2259 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04534 CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.81258 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3087 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null regulation of cell communication GO Biological Process Annotations 2015 1.0 null CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.36112 BRD-K89638177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16527 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2636 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7254 UACC257 DepMap CRISPR Gene Dependency 1.0 5.43627 TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 ESRRA_01_115 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.67925 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.898574 FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4825 CHD7 ENCODE Transcription Factor Targets 1.0 null caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.89025 BRD-K92725027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09341 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OC-314 GDSC Cell Line Gene Expression Profiles -1.0 -1.96363 regulation of phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.WT.HP_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6737 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09721398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2444 BRD-K56520977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22047 BRD-K95218317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33656 JVE127 DepMap CRISPR Gene Dependency 1.0 2.55913 BRD-K13673722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55858 Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.939 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.581 central part of CEl Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42763 HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03456 BRD-K79067166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55157 EPCAM_OE_GDS4887_343_human_IL-28B GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null LN18 CCLE Cell Line Gene Expression Profiles -1.0 -1.48132 NB1 CCLE Cell Line Gene Expression Profiles -1.0 -1.78817 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TT CCLE Cell Line Gene CNV Profiles -1.0 -1.49319 BRD-A05823365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49999 KDM5B ENCODE Transcription Factor Targets 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.37617 BRD-K43782839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1769 RBBP5 ENCODE Transcription Factor Targets 1.0 null Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30897 BRD-A38359809 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76519 BRD-K86953192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47971 cellular_component GO Cellular Component Annotations 2015 1.0 null MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K44131977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53925 BRD-K13781734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15875 Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.993985 negative regulation of metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K80009401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42679 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.4073 CRCGN011_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.736 Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.89899 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LS411N DepMap CRISPR Gene Dependency 1.0 4.02744 HCFC1 ENCODE Transcription Factor Targets 1.0 null GSE140322_3_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null SK-OV-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.41689 BRD-A46778020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.67328 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4588 BRD-K72278003 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37727 Prostate adenocarcinoma_PRAD_TCGA-CH-5750-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K11095218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31267 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051576 hsa-miR-26b-5p MiRTarBase microRNA Targets 1.0 null BRD-A35871558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13359 macromolecule modification GO Biological Process Annotations 2015 1.0 null BRD-K14037093 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.019 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K68985225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82928 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5933 protein tyrosine/serine/threonine phosphatase activity GO Molecular Function Annotations 2015 1.0 null Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.9616 BRD-K05475322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05737 TBP ENCODE Transcription Factor Targets 1.0 null BRD-K83547183 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20187 PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3237 BRD-A67697194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00389 BRD-K17482709 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47534 496100646_TCx_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 6.54982 BRD-K46623934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82579 BRD-K23292451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64852 hsa-miR-4255 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5384 EBV-B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.293 THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11415 BRD-K46015322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61582 CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.95857 UMUC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.35061 CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8298 protein modification process GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84O-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K87942399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41389 primary motor cortex (area M1, area 4)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18952 BRD-K17120673 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84611 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.848516 BRD-K02987495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63215 ventrolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22682 SHSY5Y CCLE Cell Line Gene Expression Profiles -1.0 -1.47123 BRD-K18070214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03639 VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10404 CRCGN010_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21595 BRD-K83898111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23443 protein dephosphorylation GO Biological Process Annotations 2023 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922066 hepatoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.412771 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PI-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phosphatase activity GO Molecular Function Annotations 2015 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.84989 CMK CCLE Cell Line Gene CNV Profiles 1.0 1.52812 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.00696 MAX ENCODE Transcription Factor Targets 1.0 null sustaining GeneRIF Biological Term Annotations 1.0 null liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.405678 BRD-K29246335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53604 salivary gland GTEx Tissue Gene Expression Profiles -1.0 -1.01387 NCI-H64 GDSC Cell Line Gene Expression Profiles 1.0 1.46885 CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4684 EFM192A CCLE Cell Line Gene Expression Profiles -1.0 -1.60018 EZH2 ENCODE Transcription Factor Targets 1.0 null CHK2_KD_GSE54268_668_human_MCF-10A GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.954167 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K27331198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.21302 BRD-K34256721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75642 BRD-K03221986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02127 MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1012 BRD-K77733130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11761 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.08484 regulation of primary metabolic process GO Biological Process Annotations 2015 1.0 null A204 GDSC Cell Line Gene Expression Profiles 1.0 2.34121 BRD-K59399000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14937 CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33585 GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6277 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 58.1081 BRD-A49544621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59014 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1387 BRD-K35639494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17452 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.971496 BRD-K37865854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91705 BRD-K32444429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48435 BRD-K41709602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40668 CRCGN011_HEPG2_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0831 CGTHW1 CCLE Cell Line Gene Expression Profiles -1.0 -1.49627 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47W-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular protein modification process GO Biological Process Annotations 2015 1.0 null striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.865641 BRD-K78249980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28211 ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.4676 JVM-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.64846 BRD-K88292241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33915 CRCGN015_MCF10A.WT.HP_24H:B04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13761 hsa-miR-548ai TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.33815 CRCGN014_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21785 CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5881 BRD-K62942008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56691 SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.41069 IGROV1 DepMap CRISPR Gene Dependency 1.0 2.29632 BRD-K10705624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34023 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CJUN-26792858-CHIP-SEQ-BT549-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.68557 FOXO1::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1047 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9614 PRPF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28571 BRD-K47966145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44447 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null negative regulation of protein kinase activity GO Biological Process Annotations 2015 1.0 null mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.885543 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19152 SUM229PE DepMap CRISPR Gene Dependency 1.0 2.43958 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45925 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Idiopathic fibrosing alveolitis_Lung Tissue_GSE21369 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.82865 GATA2 ENCODE Transcription Factor Targets 1.0 null FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8891 BRD-K88080911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13991 BRD-K86155080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38348 BRD-K60719499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05459 intracellular organelle lumen GO Cellular Component Annotations 2015 1.0 null BRD-K26399271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05429 PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3663 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 BRD-K52335877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39561 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.586 KRAS.600.LUNG.BREAST_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null BRD-K13888422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21372 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04102 imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02087489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06558 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066392 protein tyrosine phosphatase activity GO Molecular Function Annotations 2025 1.0 null mitochondrial matrix GO Cellular Component Annotations 2015 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6262 MDA-MB-415 COSMIC Cell Line Gene Mutation Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.7222 BRD-K73994499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.01573 MKN45 CCLE Cell Line Gene CNV Profiles 1.0 2.21602 KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K12431811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69887 BRD-K28429328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30368 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060798 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100445_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 7.62448 mitochondrial membrane part GO Cellular Component Annotations 2015 1.0 null NCIH1581 DepMap CRISPR Gene Dependency 1.0 2.42102 BRD-A14842104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18236 negative regulation of biological process GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17062 cytoplasm GO Cellular Component Annotations 2015 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K69521416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60689 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.987792 PC14 CCLE Cell Line Gene CNV Profiles -1.0 -1.57548 HMEL CCLE Cell Line Gene Expression Profiles 1.0 1.81681 BRD-K28803288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30396 CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.71546 BRD-K41603100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24333 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04824 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922781 digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080984 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.72047 extrinsic component of organelle membrane GO Cellular Component Annotations 2015 1.0 null binding GO Molecular Function Annotations 2015 1.0 null FU97 CCLE Cell Line Gene CNV Profiles 1.0 1.65214 BRD-K40494117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06233 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58196 Lung squamous cell carcinoma_LUSC_TCGA-43-2581-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KPNYN DepMap CRISPR Gene Dependency 1.0 3.62932 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17542 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23859 BRD-K57937572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66773 Acute Myeloid Leukemia_LAML_TCGA-AB-3008-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K05335635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68871 dicoumarol-2561 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.10855 HCC2157 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 negative regulation of phosphate metabolic process GO Biological Process Annotations 2015 1.0 null RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5993 Mitotic spindle pole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.668 786-0 GDSC Cell Line Gene Expression Profiles 1.0 1.5841 protein dephosphorylation GO Biological Process Annotations 2015 1.0 null BRD-K37019305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35651 BRD-K76309489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63184 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71171 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5273 Bladder Urothelial Carcinoma_BLCA_TCGA-MV-A51V-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.98964 TE11 CCLE Cell Line Gene CNV Profiles -1.0 -2.20278 Normoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.781 BRD-K27120020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47313 BRD-K09468701 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74964 BRD-K01793276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93986 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1599 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.699 BRD-K38111331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.16063 Brain Lower Grade Glioma_LGG_TCGA-DB-A75K-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mexiletine-3781 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08199068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0936 BRD-K45909830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56192 Sperm flagellum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.741363 SH4 CCLE Cell Line Gene CNV Profiles 1.0 1.3428 regulation of intracellular signal transduction GO Biological Process Annotations 2015 1.0 null mitochondrial part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10352 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4884-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00084 OCILY19 DepMap CRISPR Gene Dependency 1.0 2.02934 Craniofrontonasal syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 CRCGN015_HEPG2_48H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4471 BRD-K75440064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80879 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41345 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-K96969336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49882 BRD-K53617314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02783 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35106 Motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.71465 BRD-K24170552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64494 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.61415 Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8353 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.25204 GSE88819_7_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0879 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.45987 BRD-K02329600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3434 Phosphoric acid HMDB Metabolites of Enzymes 1.0 null BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5132 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K76680796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0607 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K77518191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99324 BRD-K95922469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91003 mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5406 BRD-K12239796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3112 BRD-K16479784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20705 BRD-K23430114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48839 protein metabolic process GO Biological Process Annotations 2015 1.0 null ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.1507 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3417-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23162004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78898 BRD-A36774080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08276 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null MLX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8649 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60453579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36585 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.138 PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70135 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.84722 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81262 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56231 BRD-K14706855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05649 BRD-K87754766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08143 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.354643 biological regulation GO Biological Process Annotations 2015 1.0 null BRD-A05828965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56853 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2968 CRCGN017_MCF10A.TP53.M_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.55544 BRD-K25176380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10264 outer CP in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.864182 BRD-K58432332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01008 BRD-K33891642 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16892 BRD-K38558166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07465 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null POU1F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9192 BRD-K69780027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08132 BRD-K23204256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10272 CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.93568 regulation of cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057042 ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.8452 CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.15985 BRD-K25761766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19381 BRD-K56258950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01855 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08629 liver cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.589234 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-K11428617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06063 BRD-K16852474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71455 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03588 Sperm principal piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.311 BRD-K25187028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.59072 BRD-K34741587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10089 Brain Lower Grade Glioma_LGG_TCGA-DB-5276-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21284411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3651 GSE176008_7_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2339 FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4142 ETS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6988 Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHK1_KD_GSE54267_672_human_U2OS GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32037 primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.944023 BRD-K80921954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56545 Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cystadenoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.432 negative regulation of signal transduction GO Biological Process Annotations 2015 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.26459 CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7414 Brain Lower Grade Glioma_LGG_TCGA-HT-7858-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9369 GM2493 BioGPS Cell Line Gene Expression Profiles 1.0 1.57766 BRD-K05357297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94961 BRD-K37527074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12127 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.12133 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.62014 Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.75 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845376 BRD-K24178822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90839 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66889 OLIG2-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 THP-1 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 SYNCRIP_02_10 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58854 BRD-K11672894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55195 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.909626 BRD-K56591923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02057 BRD-K59130962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2592 BRD-K16717067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08021 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.20757 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858825 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18888 BRD-K86774687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40677 GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58285 BRD-K84062787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.26052 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02858 NOZ DepMap CRISPR Gene Dependency 1.0 4.95893 BRD-K74677971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0658 ETS1-21867929-TH2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K31521981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07842 Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3155 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K47028303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13098 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.49652 BRD-K21635266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77194 WSUDLCL2 CCLE Cell Line Gene Expression Profiles 1.0 1.3524 BRD-K12782513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06116 E2F1-17053090-MCF7-human ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K57650037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11313 CAMA1 DepMap CRISPR Gene Dependency 1.0 2.0409 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19902 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.16886 HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39656 NCIH1573 CCLE Cell Line Gene Expression Profiles -1.0 -2.11959 IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7473 phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K20171002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21966 BRD-K90460185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33894 LB1047RCC DepMap CRISPR Gene Dependency 1.0 2.184 BRD-K18178356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61026 CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN013_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6713 GSE248634_1_v_0_gnas_human RummaGEO Gene Perturbation Signatures 1.0 null OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828214 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.959114 BRD-K56716645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08671 AU565 CCLE Cell Line Gene CNV Profiles 1.0 1.53596 HCC38 CCLE Cell Line Gene Expression Profiles -1.0 -1.76964 BRD-K03849840 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08841 UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1387 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K48691065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34205 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.47795 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50869 deferoxamine-3936 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K62807053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84348 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null negative regulation of catalytic activity GO Biological Process Annotations 2015 1.0 null inactivation of mapk activity GO Biological Process Annotations 2015 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null BRD-K45097650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22627 dorsolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22549 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38467 digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RL CCLE Cell Line Gene Expression Profiles 1.0 1.58287 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-AB2P-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4309 GSE201309_1_v_0_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null C10 DepMap CRISPR Gene Dependency 1.0 2.47146 BRD-K60898929 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20646 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885335 HUH1 CCLE Cell Line Gene CNV Profiles 1.0 1.79836 CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.64406 mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 ATF1 ENCODE Transcription Factor Targets 1.0 null BRD-K73394628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82421 PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PLC-PRF-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.944 BRD-K74382273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31911 BRD-A96536816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21491 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.20476 COR-L311 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 phosphoric ester hydrolase activity GO Molecular Function Annotations 2015 1.0 null BRD-K77032979 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.21614 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62093 c-MYC_KD_GDS2526_110_human_BT-474 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE201309_1_v_2_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null MES-SA COSMIC Cell Line Gene Mutation Profiles 1.0 null CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.04622 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13611 CRCGN008_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5739 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48155 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8666-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K22139757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37366 Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6506-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOS CCLE Cell Line Gene CNV Profiles 1.0 2.35332 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.92453 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.952889 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05781 CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3272 CRCGN014_HEPG2_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24844 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5676-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1966 HUT102 CCLE Cell Line Gene Expression Profiles 1.0 1.64277 BRD-K95111937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17988 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.94476 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K90429860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29968 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4504 CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.488 FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5639 BRD-K68980973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23193 trovafloxacin_homo sapiens_gpl96_gse9166 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3654 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null negative regulation of intracellular signal transduction GO Biological Process Annotations 2015 1.0 null BRD-K23670243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2716 BRD-K06177900 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05732 regulation of molecular function GO Biological Process Annotations 2015 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:L11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.84159 ventrolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.853334 inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.15055 Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.4652 Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRTA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9081 outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.959034 SOX4 MotifMap Predicted Transcription Factor Targets 1.0 null layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18575 BRD-K53257307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07745 Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K81939454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41814 BRD-K75900952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02473 BRD-K78813464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43913 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RJ-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MKN1 CCLE Cell Line Gene Expression Profiles -1.0 -1.49849 GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K07502463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03779 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0476 BRD-K37544873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06908 BRD-K62547690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27611 BRD-K45073068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07766 liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.384822 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05857 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-K60192542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11122 CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.57102 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.879731 BRD-K96389533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18833 GSE140322_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.910209 negative regulation of map kinase activity GO Biological Process Annotations 2015 1.0 null BRD-K93023309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22793 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03341 layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13537 BRD-K69594935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66061 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.53494 GATA3-21867929-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-1323 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adenoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null EEF1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -7.82121 MIAPACA2 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 BRD-K91490997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00131 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF4-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K64535513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0767 BRD-K22988729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12815 negative regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null GSE76425_0_v_3_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51063 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEL270 DepMap CRISPR Gene Dependency 1.0 3.49656 WHSC1 ENCODE Transcription Factor Targets 1.0 null BRD-K42582718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08327 OV90 CCLE Cell Line Gene Expression Profiles 1.0 2.15964 PSIP1_Deficiency_GDS2883_633_human_T-cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07231 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.25723 NCI-H1770 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K79318338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01906 Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null 496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 7.70741 BRD-K65780164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13527 BRD-K05616059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33631 BRD-K75869048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66908 lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.825151 BRD-K22447639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22296 BRD-K90675978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16575 KMBC2 CCLE Cell Line Gene CNV Profiles -1.0 -2.3514 metacetamol LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60466 BRD-K13844473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3901 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.11309 GCT CCLE Cell Line Gene Expression Profiles -1.0 -1.77113 CRCGN017_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81147 BRD-K15393664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.0549 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15349 496100574_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.67171 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JA-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:O23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05565 BRD-K27154831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41615 BRD-K38118226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49629 NCI-H650 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.22235 BRD-K78866450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17006 CAL51 CCLE Cell Line Gene Expression Profiles 1.0 1.66132 BRD-K56188108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80191 BRD-K01639343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23097 BRD-K12955049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07733 HCC38 CCLE Cell Line Gene CNV Profiles -1.0 -1.76093 E2F1-17053090-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.1129 BRD-K54751293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13597 18537972-TableS4 GeneSigDB Published Gene Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.76407 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26725 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7452 NCI-SNU-5 GDSC Cell Line Gene Expression Profiles -1.0 -1.81511 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39132 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13303 LC1SQSF CCLE Cell Line Gene CNV Profiles -1.0 -1.67734 OVCAR3 BioGPS Cell Line Gene Expression Profiles 1.0 0.90015 cellular metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K96652989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09206 Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.127 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8819 map kinase tyrosine/serine/threonine phosphatase activity GO Molecular Function Annotations 2015 1.0 null negative regulation of signaling GO Biological Process Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-01A-31R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of phosphate metabolic process GO Biological Process Annotations 2015 1.0 null MLXIPL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7853 CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.0199 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26777 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057075 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CMK115 DepMap CRISPR Gene Dependency 1.0 2.80605 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2819 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 small intestine GTEx Tissue Gene Expression Profiles 1.0 1.68617 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 2.2267 Calcium HMDB Metabolites of Enzymes 1.0 null BRD-K31204557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28422 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23155 BRD-K06220918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.34498 BRD-K86237035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50831 CMK115 CCLE Cell Line Gene CNV Profiles 1.0 1.92692 HDAC1 ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null Dual specificity phosphatase, subgroup, catalytic domain InterPro Predicted Protein Domain Annotations 1.0 null SNU119 CCLE Cell Line Gene Expression Profiles -1.0 -2.31857 786 BioGPS Cell Line Gene Expression Profiles 1.0 1.04709 SIX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4449 bladder GTEx Tissue Gene Expression Profiles -1.0 -1.01387 BRD-K45732260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0216 SW403 DepMap CRISPR Gene Dependency 1.0 5.65099 CRCGN015_HEPG2_48H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.26554 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9275 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2672 SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.929706 BRD-K84048601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08418 HOXB2::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1218 Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 BRD-K81035073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27087 Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02920459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41046 BRD-K66865641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43187 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K54622858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0802 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20402 hepatocellular GeneRIF Biological Term Annotations 1.0 null thus GeneRIF Biological Term Annotations 1.0 null BRD-K17536501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4848 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78217087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03928 RCOR1 ENCODE Transcription Factor Targets 1.0 null negative regulation of transferase activity GO Biological Process Annotations 2015 1.0 null GATA3-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.644 BRD-K93176491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.49204 KDM1A ENCODE Transcription Factor Targets 1.0 null BRD-K59922784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00447 HDQ-P1 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFATC3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.533 Manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.788 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20214 BRD-K45893504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33834 BRD-K19766710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33383 CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4904 membrane-enclosed lumen GO Cellular Component Annotations 2015 1.0 null hsa-miR-4477a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 therapeutic GeneRIF Biological Term Annotations 1.0 null CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74909 BRD-K44042747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15993 membrane part GO Cellular Component Annotations 2015 1.0 null extrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null peptidyl-tyrosine dephosphorylation GO Biological Process Annotations 2015 1.0 null H3K36me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63504496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71488 SUIT-2 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79555196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26087 BRD-K23203419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27194 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26465 KE39 CCLE Cell Line Gene CNV Profiles -1.0 -1.43213 Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rge TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.599 SNU5 CCLE Cell Line Gene CNV Profiles 1.0 1.7496 negative regulation of protein modification process GO Biological Process Annotations 2015 1.0 null KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922066 X-linked cleft palate with or without ankyloglossia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.51 Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10881763-DataSheet_1.pdf-5-DOT1L_DOT1L Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7788-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 BRD-K67484361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19445 GSE140322_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-01A-12R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:B11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69267 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null negative regulation of cellular process GO Biological Process Annotations 2015 1.0 null BRD-A13210451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.316 BRD-K61795707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96177 BRD-K66841501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12156 regulation of protein modification process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56572 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18408 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06782 BRD-A14098586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06993 BRD-K81001899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05791 T47D CCLE Cell Line Gene CNV Profiles 1.0 1.71265 18713946-TableS3 GeneSigDB Published Gene Signatures 1.0 null BRD-K22944782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3869 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6783 CRCGN015_HEPG2_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.086 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.19252 BRD-A15454510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85997 BRD-K96384208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45124 CRCGN016_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.51777 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.227 MAP2K1_knockdown_134_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.00237 BRD-K17107214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.47229 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8626-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95810752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68092 BRD-K59667434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15049 EJM CCLE Cell Line Gene Expression Profiles 1.0 1.45229 VMRCRCZ CCLE Cell Line Gene Expression Profiles -1.0 -2.03143 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.0392 CDK4_knockdown_133_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.48842 BRD-K98731550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40638 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.19184 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5183-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23336 PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13 Rummagene Transcription Factor Associations 2026 1.0 null Mesothelioma_MESO_TCGA-TS-A7OY-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.853847 BRD-K94469522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57812 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43581 BRD-K72098698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34776 BRD-K80546581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28885 chloroxylenol LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84418 CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3533 SMAD1-26771354-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0217 COV362 CCLE Cell Line Gene CNV Profiles 1.0 1.55915 organelle lumen GO Cellular Component Annotations 2015 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055393 protein tyrosine phosphatase activity GO Molecular Function Annotations 2015 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CRCGN015_MCF10A.TP53.M_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9879 CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.51469 SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07101 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.848 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null BRD-K88447092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35318 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9909 42-MG-BA COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15800236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52581 negative regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of mapk cascade GO Biological Process Annotations 2015 1.0 null BRD-K67931592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87626 CRCGN015_MCF10A.WT.HP_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08249 JVM2 CCLE Cell Line Gene Expression Profiles 1.0 1.38053 NCIH1355 CCLE Cell Line Gene CNV Profiles 1.0 1.47787 TGBC24TKB GDSC Cell Line Gene Expression Profiles 1.0 2.00384 SNU119 CCLE Cell Line Gene CNV Profiles 1.0 1.41919 Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60758969 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45641 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.7371 NR2F2 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8104-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of transferase activity GO Biological Process Annotations 2015 1.0 null CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0791 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.601178 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.674 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Protein-tyrosine phosphatase, active site InterPro Predicted Protein Domain Annotations 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.93141 primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.851954 ventral anterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08559 Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.593 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A57536034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35961 BRD-K58028568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76284 TYK2_KD_GDS4754_158_human_JURKAT GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null myclobutanil LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45605 BRD-K51787437 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8762 CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.4382 HCC2218 CCLE Cell Line Gene Expression Profiles 1.0 1.45408 BRD-K12396271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09598 BRD-K50859531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24066 BRD-K21363211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43445 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19902 hsa-miR-4287 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 regulation of protein kinase activity GO Biological Process Annotations 2015 1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A6XA-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85908443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1363 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null liver TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.4 E2F1 ChEA Transcription Factor Targets 1.0 null BRD-K96713984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72827 MIA-PACA-2 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 proliferation GeneRIF Biological Term Annotations 1.0 null BRD-K13110695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44859 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.6188 ZNF211 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.6096 BRD-K12633506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10926 CRCGN017_MCF10A.TP53.M_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03304 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48317 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80196706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08129 SNU308 CCLE Cell Line Gene CNV Profiles -1.0 -1.38325 BRD-K27335290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24842 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16944 IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32996 BRD-K05414181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.95312 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47964 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16284 BRD-K50716325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30772 BRD-K06403738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74319 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4557 CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.68805 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.72541 BRD-K35441510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71557 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1993 DepMap CRISPR Gene Dependency 1.0 2.46861 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22818 BRD-K84636055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.46813 BRD-K17765399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29828 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45715 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K73929798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14797 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054119 BRD-K63420290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23742 BRD-K31215362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51414 CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91196 CCK81 DepMap CRISPR Gene Dependency 1.0 5.03853 cell part LOCATE Predicted Protein Localization Annotations 1.0 null FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7265 Bcl11b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5577 SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 BRD-K64132098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.46013 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null CRCGN013_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22524 BRD-K28545166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17003 BRD-K49490091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15297 BRD-K31407552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38882 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colon GTEx Tissue Gene Expression Profiles 1.0 1.1315 BRD-K19734887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09474 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALVA31 BioGPS Cell Line Gene Expression Profiles 1.0 1.09198 CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.3974 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null protein tyrosine phosphatase activity GO Molecular Function Annotations 2023 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4390-01A-02R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K55638368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08233 MS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null yy2_20215434_hela_lof_human_gpl570_gds3788 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.072978 HMGN3 ENCODE Transcription Factor Targets 1.0 null KMS26 CCLE Cell Line Gene CNV Profiles -1.0 -1.54659 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2934 BRD-K19523037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2206 xylometazoline-2107 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072413 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2081 BRD-K11844807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31345 NKX3-1 JASPAR Predicted Transcription Factor Targets 1.0 null homatropine-methylbromide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37092 IZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.924478 CRCGN009_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6851 Adrenocortical carcinoma_ACC_TCGA-OR-A5K1-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13939 BRD-K97122937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21942 BRD-K49530286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12407 protein dephosphorylation GO Biological Process Annotations 2025 1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.1013 BRD-K03937692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27639 BRD-K72580121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74973 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K33102216 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27303 Brain Lower Grade Glioma_LGG_TCGA-HW-8319-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K47415214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.48571 BRD-K44483161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1 membrane LOCATE Predicted Protein Localization Annotations 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null phosphoprotein phosphatase activity GO Molecular Function Annotations 2015 1.0 null amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.35979 phosphate-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null MG63 DepMap CRISPR Gene Dependency 1.0 2.33367 BRD-A83387524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39262 NCIH727 CCLE Cell Line Gene CNV Profiles 1.0 1.54694 mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_1_v_6_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null negative regulation of mapk cascade GO Biological Process Annotations 2015 1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.911659 Husk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.527 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.893 BRD-K84348716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46123 OCUG1 DepMap CRISPR Gene Dependency 1.0 2.0356 MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0175 BRD-K38966099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34521 WSU-NHL GDSC Cell Line Gene Expression Profiles 1.0 1.61437 496100284_FWM_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.76178 BRD-K28029070 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02004 BRD-K18031793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27822 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.0249 NCIH2085 CCLE Cell Line Gene Expression Profiles 1.0 2.19554 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34459 BRD-K78119702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04895 ERMES complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.624 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -1.85777 RPMI7951 CCLE Cell Line Gene CNV Profiles 1.0 1.74232 Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.1433 MFM-223 COSMIC Cell Line Gene CNV Profiles 1.0 2.15822 CUX1 ENCODE Transcription Factor Targets 1.0 null layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14395 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.9936 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-01A-31R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K69389910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10452 BRD-K16621460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16002 BRD-K19089958 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54772 breast GTEx Tissue Gene Expression Profiles 1.0 0.864961 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0476 Brain Lower Grade Glioma_LGG_TCGA-DU-6542-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K55852567 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13602 ZNF157 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6063 PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1 Rummagene Transcription Factor Associations 2026 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07925 BRD-K40923781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09159 pyramidal layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02691 RGS2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K25868508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00023 ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.0029 BCAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27404 Brain Lower Grade Glioma_LGG_TCGA-DU-7010-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBX1 ChEA Transcription Factor Targets 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K52139780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07471 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4039 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14993 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839674 imatinib_homo sapiens_gpl96_gds3048 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K01225247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29733 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96187 BRD-K43901257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10409 496100629_HIP_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.68579 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.91641 POLR3A_01_139 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.16012 TUHR10TKB CCLE Cell Line Gene Expression Profiles -1.0 -1.45977 BRD-K82504878 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48693 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.995613 BRD-K73227372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82561 BRD-K57343972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06368 BRD-K69468381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35431 JK1 CCLE Cell Line Gene Expression Profiles 1.0 1.83342 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3994 BRD-K58193973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17491 BRD-K28455914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20491 POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 65.843 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877222 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23864 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null Plant cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.8 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45695 capsaicin-5673 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81537454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04928 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IP-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUGC-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.54896 BRD-K42873980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32731 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.1003 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.05183 BRD-K27137352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43312 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 58.8812 Mecom JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.5185 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null treatment GeneRIF Biological Term Annotations 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-8648-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hepatoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.60249 CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.54184 hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04196 GSE140322_3_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041222 peptidyl-tyrosine dephosphorylation GO Biological Process Annotations 2023 1.0 null SQ1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44463 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.89762 Sarcoma_SARC_TCGA-FX-A3RE-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hcc GeneRIF Biological Term Annotations 1.0 null IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68956 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 CCLE Cell Line Gene Expression Profiles -1.0 -2.07433 Enterovirus 71_4Hour_None_GSE15323 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.5213 regulation of kinase activity GO Biological Process Annotations 2015 1.0 null BRD-K62909525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45414 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15703 Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.42089 Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5 Rummagene Transcription Factor Associations 2026 1.0 null AML193 CCLE Cell Line Gene Expression Profiles 1.0 1.52181 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.97328 RBM34_02_141 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.7101 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K57059449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22758 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839674 BRD-K75869095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59891 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51F-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 119.925 GSE76425_0_v_10_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96284156 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27598 CRCGN015_HEPG2_48H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30321 BRD-K83466873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15876 CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57285 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42758 organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 negative regulation of phosphorylation GO Biological Process Annotations 2015 1.0 null KU-812 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.601 BRD-K50623282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23221 Protein phosphatase 4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.778 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.967457 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5201-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.98877 BRD-K35671498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26794 CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.94193 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054173 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QH-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUGC4 CCLE Cell Line Gene Expression Profiles 1.0 1.92913 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RO-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32185628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07764 nucleus GO Cellular Component Annotations 2015 1.0 null MKN74 CCLE Cell Line Gene Expression Profiles 1.0 1.72256 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T98G COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6756 Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KQ-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-A4WN-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K22534934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66715 BRD-A95207036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57031 OVK18 CCLE Cell Line Gene Expression Profiles -1.0 -2.08671 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.948894 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53773 BRD-K52119965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97524 DMS-273 COSMIC Cell Line Gene Mutation Profiles 1.0 null 143B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66566 BRD-K98008739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14916 BRD-K10748141 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02188 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-27129775-CHIP-SEQ-CORNEA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K14868348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20163 Kabuki syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 EP300 ENCODE Transcription Factor Targets 1.0 null TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5287 STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7426 BRD-K89724519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26575 LU-135 GDSC Cell Line Gene Expression Profiles 1.0 1.46865 BRD-K47707657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3336 CRCGN015_HEPG2_48H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9974 Ankyloglossia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 PFEIFFER CCLE Cell Line Gene Expression Profiles 1.0 1.70669 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83125173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.69695 BRD-K03995743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07902 BRD-K96295480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71287 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922066 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K41746201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98085 ZXDC_KD_GDS5070_504_human_U937 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K29802952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3256 BRD-A26343863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3259 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.2333 BRD-K83645749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38489 Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6602 CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66405 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1976 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.69457 CH157MN CCLE Cell Line Gene Expression Profiles 1.0 1.93057 Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13351 SNU840 DepMap CRISPR Gene Dependency 1.0 2.97139 BRD-K11700411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14057 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.233162 BRD-A33119430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27483 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.897613 BRD-K74056311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09731 negative regulation of protein serine/threonine kinase activity GO Biological Process Annotations 2015 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.19286 BRD-K06830450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20947 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00708 BRD-K27754030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21581 BRD-K44643967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.50742 BRD-K47143916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49769 ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3865 SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922066 ZXDC1_KD_GSE45417_686_human_U937 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05737 GSE201309_4_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.6046 peptidyl-tyrosine dephosphorylation GO Biological Process Annotations 2025 1.0 null BRD-K10092312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5139 Lung squamous cell carcinoma_LUSC_TCGA-22-4604-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55386 TEAD4 ENCODE Transcription Factor Targets 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKBR3 CCLE Cell Line Gene CNV Profiles 1.0 1.61222 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.872267 BRD-K99833695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09905 hsa-miR-4685-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.61042 Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSC3 CCLE Cell Line Gene Expression Profiles 1.0 1.51178 CRCGN015_MCF10A.WT.HP_24H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.03825 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061526 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K93126086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47325 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K54939987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38418 BRD-K18142082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28384 GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MedullaOblongata BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.17953 BRD-K97569931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04352 CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.69875 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.61894 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2393 Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.081 BICR18 CCLE Cell Line Gene CNV Profiles 1.0 1.44865 BRD-K95121261 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0193 BRD-K42465630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46175 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.891774 BRD-K35588268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55497 NONO_02_65 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61386 RAC3-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUIT2 CCLE Cell Line Gene CNV Profiles -1.0 -2.0931 CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33692 Axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.668 GATA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8945 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SL-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4697-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01561 BRD-K34602185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32084 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.847309 map kinase phosphatase activity GO Molecular Function Annotations 2015 1.0 null CRCGN016_MCF10A.WT.HP_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70675 Phosphate HMDB Metabolites of Enzymes 1.0 null G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24509 cervix uteri GTEx Tissue Gene Expression Profiles -1.0 -1.01387 CRCGN010_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5943 cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K46620987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48557 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38178 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.381003 DU-4475 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13611 BRD-K04667232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37192 BRD-K68683482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64818 CRCGN015_HEPG2_48H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.60467 HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25842 EFO21 CCLE Cell Line Gene CNV Profiles -1.0 -1.6071 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09975619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27671 BRD-K18562847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39102 GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null KMH-2 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50379 ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.3962 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928825 BRD-K65399214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31726 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.913279 BRD-K50210179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6099 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.928768 cellular process GO Biological Process Annotations 2015 1.0 null regulation of protein metabolic process GO Biological Process Annotations 2015 1.0 null sperm flagellum GO Cellular Component Annotations 2025 1.0 null PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63 Rummagene Transcription Factor Associations 2026 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles -1.0 -1.64084 primary motor cortex (area M1, area 4)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60869 fallopian tube GTEx Tissue Gene Expression Profiles -1.0 -1.01387 liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.103014 TE-11 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.261 Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.373 OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928825 ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0358 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MHHES1 CCLE Cell Line Gene Expression Profiles -1.0 -1.78363 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00076 SYK_druginhibition_154_GSE34176 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.54996 GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null extrinsic component of mitochondrial inner membrane GO Cellular Component Annotations 2015 1.0 null plc-prf-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.29444 BRD-K09819684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97238 OCIM1 CCLE Cell Line Gene Expression Profiles 1.0 3.40791 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null BRD-K14309706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79763 BRD-K41604824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56841 NCCSTCK140 CCLE Cell Line Gene CNV Profiles 1.0 2.00702 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21544 H3K27me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56896 BRD-K20735575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55249 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78P-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07484899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47124 BRD-K26461918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00696 BRD-K22957824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38244 Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.081067 negative regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5808 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78451 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17537 Acute Myeloid Leukemia_LAML_TCGA-AB-2979-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null negative regulation of cell communication GO Biological Process Annotations 2015 1.0 null regulation of signaling GO Biological Process Annotations 2015 1.0 null CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.40171 inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.832159 Kidney Chromophobe_KICH_TCGA-KO-8407-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.6006 9+2 motile cilium GO Cellular Component Annotations 2025 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039468 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.04959 regulation of protein serine/threonine kinase activity GO Biological Process Annotations 2015 1.0 null BRD-K27050140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21244 Mitochondrial alpha-ketoglutarate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.806 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null act GeneRIF Biological Term Annotations 1.0 null G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.71171 PR, GR MotifMap Predicted Transcription Factor Targets 1.0 null Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Caput epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.706 ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.832972 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1_DEPLETION_GDS2189_121_human_MCF10A mammary epithelial cells (MECs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K31479652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12522 BRD-K85532500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08077 negative regulation of phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 JASPAR Predicted Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IV-01A-22R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0945 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.5751 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9063 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839073 Kidney Chromophobe_KICH_TCGA-KO-8415-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66245 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7615 NCIH2228 CCLE Cell Line Gene Expression Profiles -1.0 -1.82878 BRD-K02681754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04568 BRD-K05228434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85078 Protein-tyrosine/Dual specificity phosphatase InterPro Predicted Protein Domain Annotations 1.0 null BRD-K68364310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83915 regulation of catalytic activity GO Biological Process Annotations 2015 1.0 null BRD-K41009039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73289 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.90699 BRD-K05940224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.76437 BRD-K34519525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23376 CRCGN017_MCF10A.WT.HP_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08723 BRD-K80306055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50374 MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.0266 BRD-K94196749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26155 CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.05337 BRD-K09373762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26579 IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72278 CRCGN016_MCF10A.WT.HP_24H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5837 GM97 BioGPS Cell Line Gene Expression Profiles 1.0 2.09968 organelle part GO Cellular Component Annotations 2015 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K02839126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58148 parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.836564 BRD-K32000549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46212 THP1 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 CRCGN011_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.99025 9+2 motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 CRCGN017_MCF10A.WT.HP_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40888 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5489 GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null 19567819-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915589 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.9845 NFYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5677 BRD-K67715154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83141 LIM1215 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.169 CRCGN014_HEPG2_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.58029 Lung squamous cell carcinoma_LUSC_TCGA-21-1076-01A-01R-0692-07,TCGA-21-1076-01A-02R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null liver cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.091666 BRD-K50272743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36733 CRCGN008_HEPG2_24H:I21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4684 BRD-K52383401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16534 FOS ENCODE Transcription Factor Targets 1.0 null BRD-K09972656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27497 BRD-A82976259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05058 NCIH650 CCLE Cell Line Gene CNV Profiles -1.0 -1.80972 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K33734659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85797 BRD-K31721388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24561 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.407453 BRD-K43637338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.784 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6234 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20829034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78406 SUIT-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.41069 CRCGN008_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.618 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30269 MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 2.5998 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K91952416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03837 ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8862 CRCGN015_HEPG2_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.15363 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.87265 POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.1967 regulation of protein phosphorylation GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.TP53.M_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.83781 CRCGN015_HEPG2_48H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.54875 BRD-K56427898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13553 CRCGN013_HEPG2_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19846 CAL78 CCLE Cell Line Gene CNV Profiles 1.0 1.87868 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.41069 CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35992 BRD-K86925685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93947 BRD-K24226959 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74461 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4775 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00643 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28929 Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null BRD-K97624648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38741 CRCGN010_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60447 CTCF ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12671 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928825 CRCGN013_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33118 BRD-K95035301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09486 HL60 BioGPS Cell Line Gene Expression Profiles -1.0 -1.40719 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4358 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UT7 CCLE Cell Line Gene Expression Profiles 1.0 2.65492 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0779 HDAC6 ENCODE Transcription Factor Targets 1.0 null HS944T CCLE Cell Line Gene Expression Profiles -1.0 -2.50225 ES5 GDSC Cell Line Gene Expression Profiles 1.0 1.50879 BRD-K69901388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20937 X-linked intellectual developmental disorder 109 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.457 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1I3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4091 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K68086276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05876 Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.041 A498 GDSC Cell Line Gene Expression Profiles -1.0 -1.96563 molecular_function GO Molecular Function Annotations 2015 1.0 null CRCGN017_MCF10A.WT.HP_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7612 BRD-K37454185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54362 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.89745 ZNF384_02_27 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62099 CRCGN012_HEPG2_24H:N19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26336 GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.0978 BRD-K06313694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2035 ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0418 CRCGN010_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81723 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null mitochondrial part GO Cellular Component Annotations 2015 1.0 null Intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KM12 BioGPS Cell Line Gene Expression Profiles 1.0 1.47284 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.914886 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29031 BRD-A30962679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37431 BRD-K64180195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18416 MZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13114 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.3273 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67387 intracellular organelle GO Cellular Component Annotations 2015 1.0 null CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59595 TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.6263 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03979 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K76713298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63507 CRCGN013_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01052 medial nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.940056 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04515 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.651476 TAL1 ENCODE Transcription Factor Targets 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.997624 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atypical dual specificity phosphatase, subfamily B InterPro Predicted Protein Domain Annotations 1.0 null dephosphorylation GO Biological Process Annotations 2015 1.0 null NCIH747 CCLE Cell Line Gene CNV Profiles -1.0 -1.48353 CRCGN010_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.87938 RFX1 MotifMap Predicted Transcription Factor Targets 1.0 null Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 63.0477 CRCGN017_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0876 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041502 negative regulation of protein phosphorylation GO Biological Process Annotations 2015 1.0 null CRCGN012_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.44585 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01827055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83434 KYSE270 CCLE Cell Line Gene Expression Profiles -1.0 -1.50711 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051761 BRD-K05057860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37459 BRD-K56086519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13586 Tcf21 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.9909 CEBPD_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12336887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03913 PATU8988T DepMap CRISPR Gene Dependency 1.0 2.20655 BRD-K97263385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27226 regulation of biological process GO Biological Process Annotations 2015 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30799912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71648 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.932617 BRD-K40602242 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23161 BRD-K87080232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04531 Dual specificity phosphatase, catalytic domain InterPro Predicted Protein Domain Annotations 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04515 organelle GO Cellular Component Annotations 2015 1.0 null MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8122 496100450_HIP_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.45122 BRD-K19501975 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05058 BRD-K66253165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66697 YY1 ENCODE Transcription Factor Targets 1.0 null BRD-K08389897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43032 BRD-K74701308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41492 Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82882121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39036 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.092 Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42575648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00075 BRD-K81758631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44059 CCC5 DepMap CRISPR Gene Dependency 1.0 3.80914 SAP30 ENCODE Transcription Factor Targets 1.0 null BRD-K91593159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8242 PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07101 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04515 CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34203 SNUC1 DepMap CRISPR Gene Dependency 1.0 11.0013 metabolic process GO Biological Process Annotations 2015 1.0 null IGR1 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 MYC ENCODE Transcription Factor Targets 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548ag TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K24443173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26991 BRD-K17395396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32036 BRD-K15827385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0473 ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.5433 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.94705 ERF::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0785 biological_process GO Biological Process Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14524 HPAC CCLE Cell Line Gene Expression Profiles -1.0 -1.71853 FOXP1_01_208 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.75596 MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.41069 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5106 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5489 Oc cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.805 BRD-K59709341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55597 BRD-K26063034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54707 Lymphnode BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.65537 BRD-K47410882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28446 HUH7 CCLE Cell Line Gene CNV Profiles 1.0 1.33597 BRD-K96560179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66493 CRCGN015_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2888 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20665 Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NN-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDST8 DepMap CRISPR Gene Dependency 1.0 16.332 BRD-K98355012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78078 BRD-K08939002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17953 BRD-A25537246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4763 Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 64.2319 organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30142 Lung squamous cell carcinoma_LUSC_TCGA-85-A512-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K67591072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.658 TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 1.0 7.21239 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839073 BRD-K78755361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2771 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.59014 CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null NUDUL1 CCLE Cell Line Gene CNV Profiles 1.0 1.3695 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 71.5799 HCC2279 CCLE Cell Line Gene CNV Profiles -1.0 -1.40286 SETDB1 ENCODE Transcription Factor Targets 1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.95587 BRD-K15378071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24176 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.61272 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of signal transduction GO Biological Process Annotations 2015 1.0 null mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 negative regulation of kinase activity GO Biological Process Annotations 2015 1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060497 Adrenocortical carcinoma_ACC_TCGA-OR-A5LR-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78445 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30395 hsa-miR-548o TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 OCUBM DepMap CRISPR Gene Dependency 1.0 8.18674 BRD-K74971765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04018 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.972194 Intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 139.363 496100291_TCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.3282 BRD-K60653414 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27932 CRCGN016_MCF10A.WT.HP_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.1255 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47964 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.31675 BRD-K99971319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38331 SF539 BioGPS Cell Line Gene Expression Profiles -1.0 -1.15825 JHOS2 CCLE Cell Line Gene CNV Profiles -1.0 -1.8646 TR146 DepMap CRISPR Gene Dependency 1.0 4.94101 CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.61871 CRCGN016_MCF10A.WT.HP_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1563 CRCGN014_HEPG2_3H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48225 EBV-PBL cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.073 CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6112 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0178 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24509 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2561 BRD-K14414396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36983 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00842 U2OS CCLE Cell Line Gene CNV Profiles 1.0 2.09604 BRD-K02793474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24361 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053958 BRD-K01039605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08732 BRD-K17840858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01323 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.5923 BRD-A52893269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09684 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K50066702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17204 CRCGN015_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1977 BRD-K82785545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79124 regulation of phosphorylation GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7605 MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 1.00901 BRD-K48195722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02629 Sarcoma_SARC_TCGA-DX-A8BV-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69095 Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8478 BRD-K15202679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95616 BRD-K96280720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40746 Colo-320 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.585 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null stratum pyramidale of rostral CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29304 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.653 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839073 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K29547381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1615 VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31629 Sarcoma_SARC_TCGA-MB-A5Y8-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06146578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00843 CRCGN015_MCF10A.WT.HP_24H:P17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08199 BRD-K11113009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42026 K562 CCLE Cell Line Gene Expression Profiles 1.0 2.18276 Barrett Esophagus_Esophageal Tissue_GSE1420 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.61497 BRD-K74968522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34454 FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8937 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 A3KAW CCLE Cell Line Gene CNV Profiles 1.0 1.34005 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.70527 RKO GDSC Cell Line Gene Expression Profiles -1.0 -1.7019 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32021110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55723 HCC2157 CCLE Cell Line Gene CNV Profiles -1.0 -1.92896 SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03972 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null negative regulation of cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null negative regulation of molecular function GO Biological Process Annotations 2015 1.0 null GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0854 MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0686 Atypical dual specificity phosphatase InterPro Predicted Protein Domain Annotations 1.0 null BRD-K19710723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09185 colo320dm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.71 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles -1.0 -0.830021 BRD-K03730976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99253 BRD-K17285234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36084 Prostate adenocarcinoma_PRAD_TCGA-X4-A8KQ-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null kidney GTEx Tissue Gene Expression Profiles 1.0 0.85313 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928825 E2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0251 BRD-K41649962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00836 E2F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7315 primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9455 BRD-K53387776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15744 BRD-K78252315 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0461 JUND ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66922 BRD-K03602135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41286 BRD-K43029808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25153 hydrolase activity GO Molecular Function Annotations 2015 1.0 null EP300_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17713 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.885335 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13455 LPS510 DepMap CRISPR Gene Dependency 1.0 3.20798 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.900859 HS939T CCLE Cell Line Gene Expression Profiles -1.0 -2.02385 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839674 BRD-K10232513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08003 CP in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.866916 OLIG2-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K19536737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47807 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.21125 SLR23 CCLE Cell Line Gene Expression Profiles 1.0 1.54646 HDAC2 ENCODE Transcription Factor Targets 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-02A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Protein-tyrosine phosphatase-like InterPro Predicted Protein Domain Annotations 1.0 null CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88075 MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.31668 CUX1 ChEA Transcription Factor Targets 1.0 null organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K11487484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10758 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MQ-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Water HMDB Metabolites of Enzymes 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29115 SU-DHL-16 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04791118 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20163 IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.9914 Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.46093 23132-87 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K34445094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05352 BRD-K09454191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34239 BRD-K64567246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04517 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K19817946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34893 CRCGN008_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9303 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.74664 FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null H3K9me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051761 gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.192971 GATA1 ENCODE Transcription Factor Targets 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN017_MCF10A.TP53.M_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.23712 COV318 CCLE Cell Line Gene CNV Profiles -1.0 -1.35082 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.11 Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85776843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.969 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K53662389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.03211 RAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2309 BRD-K57502201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53538 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.870746 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.91166 BRD-K31081052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25635 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055657 BRD-K54576503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11927 CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.17245 BRD-K62000282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44537 GSE76425_0_v_5_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.3062 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14808 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41345 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K64317863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06468 CEBPB ENCODE Transcription Factor Targets 1.0 null BRD-K64862162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17942 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3596 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.884107 CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.40045 OVCAR8 BioGPS Cell Line Gene Expression Profiles -1.0 -1.11309 UBTF ENCODE Transcription Factor Targets 1.0 null SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.9693 CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.59685 CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85205 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6325-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K84199148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62574 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33852 STAT3 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05887 AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.847499 regulation of map kinase activity GO Biological Process Annotations 2015 1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.18177 PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K14942405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48679 BRD-K73874262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25885 HCC1599 CCLE Cell Line Gene CNV Profiles -1.0 -1.71686 BRD-K86677819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13203 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19958 BRD-K02230174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74587 CRCGN015_MCF10A.WT.HP_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20542 Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 80.3203 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14519 HCC1395 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.08463 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K73494324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01185 SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.78426 BRD-K91895574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02701 SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24509 BRD-A04231641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14152 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040689 MCF7 DepMap CRISPR Gene Dependency 1.0 4.96004 BRD-K93223696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23266 TDRD3-21172665-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.998708 hsa-miR-4698 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Brain Lower Grade Glioma_LGG_TCGA-P5-A5EU-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2342 CEBPG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9651 CTCF_02_185 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61298 Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 hydrolase activity, acting on ester bonds GO Molecular Function Annotations 2015 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80836 BRD-K28916436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17611 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dual specificity phosphatase InterPro Predicted Protein Domain Annotations 1.0 null BRD-K89632963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52409 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.863345 NCIH2126 CCLE Cell Line Gene Expression Profiles -1.0 -2.34785 CRCGN016_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.24726 496100625_FWM_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 8.61918 OLIG2 ChEA Transcription Factor Targets 1.0 null BRD-K25165359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0323 MAFF ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9091 BRD-K82927098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28994 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.717 IRF1 ENCODE Transcription Factor Targets 1.0 null BRD-K00363054 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1155 CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35993 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12542 CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.815 nucleus GO Cellular Component Annotations 2023 1.0 null CRCGN016_MCF10A.WT.HP_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.21877 BRD-K56408846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17436 CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.20299 BRD-K54478142 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14105 Ebolavirus(ZEBOV)_6day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.439762 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13611 FAM156B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02947 MAFK ENCODE Transcription Factor Targets 1.0 null BRD-K61821542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29051 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48187 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5701-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00791 BRD-K74694052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34829 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22633587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08227 ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.987792 BRD-K22475995 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00948 BRD-K11054031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85706 CHLA266 DepMap CRISPR Gene Dependency 1.0 2.80423 BRD-K99048639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61113 EN1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K12665145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47079 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79064 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31354 nucleus GO Cellular Component Annotations 2025 1.0 null NCI-H3122 COSMIC Cell Line Gene CNV Profiles -1.0 -2.85574 BRD-K08618283 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11235 BMI-1_DEPLETION_GDS2445_115_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K82432417 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0749 BRD-K17675814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88446 CRCGN015_HEPG2_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.1481 HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -2.14819 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 139.569 BRD-K73337367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07739 BRD-K23703519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03503 BHT-101 GDSC Cell Line Gene Expression Profiles -1.0 -1.92631 CRCGN010_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9678 TYKNU DepMap CRISPR Gene Dependency 1.0 3.72123 BRD-K19139070 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63606 GSE201309_1_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K03935681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20873 BRD-K61354849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31855