association	dataset	threshold value	standardized value
BRD-K81110981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5279
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PDS5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78285
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.78
RPS6KA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39633
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50718861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48421
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09124
BRD-K22071228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10245
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08508
PMC10247733-41408_2023_863_MOESM2_ESM.pdf-288-MESP2_MESP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63813316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59108
BRD-A50701104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58388
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8138
C5orf22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67329
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.772
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41029
Superior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.814
RHOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0241
BRD-K24825509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34546
FEM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62015
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54063
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.6758
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202484
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31136
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2869
BRD-K77727343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89946
BRD-K09863466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27546
BRD-K36237864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21213
BRD-K80225716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51156
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72059
BRD-K82145108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44798
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.824
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06565
BRD-K83820627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81768
BRD-K90311252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68173
LRP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75388
DERL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19376
BRD-K52731672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22238
pipenzolate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87821
RAB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11339
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.369
BRD-K09460582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1422
BRD-A77164655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12362
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TOB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16466
BRD-K25791914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77959
BRD-K48994888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23398
BRD-K75067815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28585
CRCGN015_MCF10A.TP53.M_24H:C13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20235
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7504
BRD-K83752863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94318
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.46644
BRD-K37532736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95345
BRD-K24312231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65876
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ZNF671	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42833
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05015
PMC3253802-pone.0029922.s001.pdf-107-FKHL18_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A39521712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29605
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34624391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05827
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC12079334-ADVS-12-2501734-s002.pdf-130-ENSG00000123411_IKZF4	Rummagene Transcription Factor Associations 2026	1.0	null
ATP5PB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82158
PMC3371315-NIHMS350140-supplement-13.xls-MCF7-T47D-SK-453_Up_Common_xls-Supplementary_Table_6_Luminal_Signature_Genes_increased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99331869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66494
ANKRD13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66777
BRD-K60932633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0745
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-A93436351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61796
BRD-K32240435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04846
BRD-K10011427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28387
BRD-A98795688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34929
BRD-K51608472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51798
BRD-K23997756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08643
BRD-K89194869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60177
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.7704
PMC3435504-msb201237-s2.xls-Supp_Table_4b-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
Centrosome	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.425
BRD-K92479346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83792
ATP2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49988
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08835
MED6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64455
BRD-K99412981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02219
BRD-K22778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06004
BRD-K84990603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33623
Centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26274
BRD-K46298577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01799
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WRAP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72278
BRD-A02612852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64017
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25646
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5165
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ASCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33685
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1452
BRD-K06451913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28228
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31211
PMC7687904-41598_2020_75770_MOESM1_ESM.xlsx-SP2-ENSGID_SP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89719122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40489
GNA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72808
CKAP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13783
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7598
BRD-K92644013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40184
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1455
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18461
BRD-K30963311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10499
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
NRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30231
BRD-K58534227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92404
BRD-K34942615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24774
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1513
ZM-226600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43561
Cytoskeleton organization and intracellular signaling	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.787
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tRNA (m7G46) methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.42
SUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2306
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.49847
SUCLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.084
TYRO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1514
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41248
BRD-K69348766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32532
BRD-K49529874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34127
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EVA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04746
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CEP350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95702
BRD-K45904718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62872
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83667863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41845
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27713
BRD-K22474245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11606
BRD-K04468899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11631
EYA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50267
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55072060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47306
CX3CL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00015
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39299
BRD-K39244231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11008
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95007662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44982
BRD-K76197651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18456
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K13445266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28531
BRD-K23535862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04594
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K30467307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.97366
BRD-K11662217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51106
TGDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09959
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29883
BRD-K45058172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19478
CLDN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14031
Developmental dysplasia of the hip	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7963
BRD-K91410469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54173
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83270677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.094
BRD-K16330310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05523
PMC7687904-41598_2020_75770_MOESM1_ESM.xlsx-SP2-Gene_SP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A17687311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42815
BRD-K90092568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50709
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.917
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85294251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58869
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79402882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16224
496100646_TCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21456
BRD-K31874013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07106
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56488
BRD-K53343197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18152
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3239
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65304
CRCGN011_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2455
NOP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01264
GSE124048,GSE124067_1_v_0_irf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89175823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52343
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.5434
CEP135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9248
t69-brown-adipose_female_4w	MoTrPAC Rat Endurance Exercise Training	-1.0	-6.6187
DCTN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.999
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91454
PMC7176284-pcbi.1007753.s008.xlsx-2_MYCN-NA_NBL_Multimodal_Genes-gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07740919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50388
BRD-K10189430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10719
BRD-K69453385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19702
BRD-K90316899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02021
GSE120336_0_v_2_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LRRC45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64237
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85500722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22161
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RAB2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29713
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.709
XPNPEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10252
BRD-K55939029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62272
BRD-K05086663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00319
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2925
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88263
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6628
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EBV-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4834
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7304
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8925
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33759
BRD-K81181894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96294
BRD-K63401627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47696
BRD-K78119702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24002
BRD-K18435317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57283
BRD-K12106433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09536
BRD-K34282646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73345
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29111485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51176
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K16268355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93176
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNRF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86652
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22734
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6089
BRD-K95927760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04444
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ALPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70237
BRD-K69350885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42331
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0178
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7731
WNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25312
SLC5A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76638
BRD-A12372458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85866
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3646
EYA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19193
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09994
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09802
BRD-K98374711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19011
TLCD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80406
protein methylation	GO Biological Process Annotations 2025	1.0	null
CRCGN015_MCF10A.WT.HP_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27083
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21201014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12256
RLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55566
SHARPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50295
NR1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16972
BRD-K03312699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19897
CHGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34995
Hypophosphatemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
PUS7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15679
ASB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09976
BRD-A25993094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00716
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K19752998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57772
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26355
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44126416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78056
relapsing-remitting multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10555
EIF4E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98274
BANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2063
BRD-K12524104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72676
Secondary progressive multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K83553001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38405
BRD-K98890753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36291
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35909757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0855
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K59386816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06595
BRD-K96250732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71523
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0964
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7279
BRD-K00243272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55565
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0076
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51461946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.062
BRD-K18523456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06316
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69826976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21018
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36974
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09774
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19155
SELENOI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85847
BRD-A96334094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51694
BRD-K19040998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42584
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03348
PMC6078963-41467_2018_5311_MOESM9_ESM.xlsx-PPARD_CHIP_vs_RNA_CD34-PPARD_macrophages_Vs_RNA_CD34_OE_DEGs_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00206
BRD-K63354944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17976
BRD-A65592966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16976
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7192
CENPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62546
BRD-K14470344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03941
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34753
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30548577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14737
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr12_57802664_G_A_b38	GTEx eQTL 2025	1.0	1.45881
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64301
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAB4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13948
PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A55020151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13583
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9468
GSDMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1181
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13337
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25434
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.668
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.597
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7459
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0857
BRD-K35848924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70946
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24895
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40985
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96845170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37123
TBCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77542
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75207324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13435
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNF168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1983
BRD-K54198678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20768
BRD-K98408574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75568
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2635
BRD-K00808919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74768
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7695
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68497273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33201
MAP7D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50631
CRCGN015_MCF10A.WT.HP_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4847
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91421454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79322
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94951
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3171
BRD-A12822115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88615
496100659_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35362
BRD-K07384081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51078
BRD-A03182941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02592
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30735
BRD-A94698726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21828
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16702
LAMTOR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04416
BRD-K30310008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05705
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.709
Gimen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44267
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
IMPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17728
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3884
BRD-K23481525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2978
BRD-K01045229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10645
BRD-K04371719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39606
GSE166004_1_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57544
FOXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06901
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19814
PD-128907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06957
BRD-K68558540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04545
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5646
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.20123
BRD-K44713204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27208
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K57443386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65294
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38757
BRD-K22875057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16902
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36689
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03647
BRD-K01951210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43937
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
C3orf18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31023
BRD-K54660148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11148
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1576
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92700781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32345
BRD-A71590475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38905
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.03373
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6594
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2112
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0588
BRD-K37144511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08413
BRD-K96596828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05045
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49507197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44658
BRD-K10171338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04375
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
DUSP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18479
protein-lysine N-methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54875
BRD-K89432538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80488
PMC10081388-media-2.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172020_1_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24166534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15403
BRD-K88362336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12979
BRD-K69903198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25273
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RTRAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86635
QDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21212
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207687
BRD-K64860662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06256
BRD-K36764343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50018
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68732617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00584
PMC7338542-41389_2020_247_MOESM6_ESM.xlsx-BRN2_2_of_3_DOWN_48_h-Symbol_POU3F2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88000297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66678
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF529	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3817
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SEC23IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47641
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3985
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.05296
BRD-A02927672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08028
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15759
BRD-K45732260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54954
BRD-K94306568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31439
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5638
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K84459640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81726
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.512
S100A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71805
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Eukaryotic translation elongation factor 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.557
HESX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03131
CRCGN015_MCF10A.WT.HP_24H:K17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63482
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479836
BRD-K10638173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10424
TSPYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47657
GPR108	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42444
BRD-K22510845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12311
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32313
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
NEXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67691
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K66708851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04263
BRD-K98088240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71799
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ADCK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37457
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09355
BRD-K99380757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1102
CDKN1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56889
BRD-K37433647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22907
PAGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41439
BRD-K73689413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8153
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02199
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22384464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01829
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.20958
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZSWIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37109
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94618
BRD-K48299239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1416
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.986
ZNF558	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74371
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30855
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.533
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6569
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.19707
BRD-K15123815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49907
BRD-K75588273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20903
BRD-K62068620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58117
chr12_57776552_A_G_b38	GTEx eQTL 2025	1.0	3.25091
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56076
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36468214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26913
GSE206870,GSE206872_4_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NB-1691 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Parathyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
Extrachromosomal DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
Muscle myosin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3247
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49672
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59626557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00063
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5678
SETD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22654
peptidyl-lysine modification	GO Biological Process Annotations 2025	1.0	null
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.962
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1069
BRD-K03546460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67551
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25757224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48399
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LRP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28133
BRD-K95852319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49056
Ovary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.19159
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68605096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.017
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
DENND10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95531
BRD-K19302998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11773
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64522
CWC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14796
BRD-K26680822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61766
BRD-K61753872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04248
BRD-K95688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88766
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88446
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50815029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16266
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27021
BRD-A36171447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15623
Brain morphology (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0699
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLFN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60104
BRD-K15174326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29915
BRD-K30013451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67602
GSE174383_6_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.20366
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229003
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	1.0	1.94211
CAPNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0212
BRD-K27543887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07805
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HBS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67484
BRD-K26232524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11256
Chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K13817284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10556
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BLTP3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4366
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6137
BRD-K23957028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5636
BRD-A77328129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98222
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6077
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22426
BRD-K01371603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0802
BRD-K99131664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99046
BRD-K60936953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44161
GSE164087_0_v_1_jmjd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86966177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63544
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
A-61603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07763
BRD-K64182862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82061
496100647_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26868
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54005
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74606
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13062
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03269
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53005
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91348
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43656
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-OVOL2_OVOL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01103048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14387
BRD-K01263144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14211
BRD-K85418917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37899
BRD-K14925361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11325
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A89354030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1236
TMTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20795
BRD-K92059157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21332
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82734
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5655
CRCGN015_MCF10A.TP53.M_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37875
POMGNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91306
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25976
GSE116299_4_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Chondroblastic osteosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
CRCGN017_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45095
TXNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17026
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72258
BRD-K63887881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18737
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.035
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242854
small-subunit processome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7466
BRD-K01734019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25747
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4603
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53552465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36433
BRD-K77875023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47186
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38916
chr12_57775578_T_C_b38	GTEx eQTL 2025	1.0	3.62198
BRD-K27406233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93191
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.36606
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25097691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38987
BRD-A48478073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32048
BRD-K45592944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10203
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K48717228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57634
BRD-K32199799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14684
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37893
BRD-K58498516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30286
BRD-K94385157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20012
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29355
PLAUR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03198
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.776
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1558
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.854
BRD-K54067431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24264
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0683
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2913
BRD-K86998514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13835
BRD-K15282144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0989
GSE88819_5_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88538240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04081
BRD-K62157654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05466
BRD-K53725468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84795
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A_48H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.037
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K63987422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25966
PMC6172027-elife-38795-fig2-data2.xlsx-XBP1_RNASeq_only-Gene_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49707067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60636
BRD-K90094729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60475
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25856
BRD-A01403444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43541
496100488_TCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11294
PMC10534007-Table_2.xlsx-S1_overlap_MSC_up_B_V-438_common_elements_in_BFTC905_MSC_up_and_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03141963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24816
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00005
BRD-K84541452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77539
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5684
BRD-K68916730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17205
BRD-K80679698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6651
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86638309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07971
TRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29216
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08649
BRD-K05251963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41983
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN016_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02325
BRD-K18620798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42086
ZFYVE16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34811
BRD-K06203116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12596
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05166
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr12_57779665_C_CCT_b38	GTEx eQTL 2025	1.0	3.09134
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A47166394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0252
BRD-K06020071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06505
BRD-K71592817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6167
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3536
PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80087
BRD-K84517695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40681
SIRT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73302
BRD-A96183603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7236
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
C10orf95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22291
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77665
BRD-K24333636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01481
BRD-K13164804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24217
EIF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19318
BRD-K69294714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93993
BRD-K29542628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07387
BRD-K96979108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81473
TXNL4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16932
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32357
NUDT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25812
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16095
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95595
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.2974
SF3B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89064
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5104
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0527
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.32
GSE116299_6_v_1_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K14375485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32392
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38148
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44622259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14721
BRD-A67697194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01147
CRCGN015_MCF10A.TP53.M_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9096
BRD-K42976515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09276
BRD-K55884477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37415
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25621
BRD-K14732209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29243
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07627
BRD-K30530468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35836
BRD-K29543978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27892
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204774
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1995
FDPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57522
BRD-K79494396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82273
PISD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17435
BRD-K13844473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45599
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205556_2_v_0_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1851
BRD-K32960568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98163
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
PWWP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04328
BRD-A67787745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87014
BRD-K14589361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1147
BRD-K78074905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29275
BRD-A23955117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42517
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
PDLIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83479
ARL6IP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1015
BRD-K22069962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54929
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SKIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44809
BRD-A55025683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16719
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54839
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33925
NAIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69
NRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32044
Microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K90769476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.188
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.6938
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47887272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05711
CTSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03232
BRD-K74107343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26683
BRD-K24471810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54133
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K66032509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17455
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4114
BRD-K56381552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8958
BRD-K38694430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.25215
BRD-K81288338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63615
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ARHGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37029
GSE203429_0_v_1_angptl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25081075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01769
BRD-K89837874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02275
BRD-K57042334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57725
COPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46957
TMEM229A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85702
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24125
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
BRD-K07473245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26586
RASL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14089
BRD-K07365255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86051
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.2677
BRD-K18600476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24614
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00627
dilazep-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39867
BRD-K84478344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33401
BRD-K71213946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31005
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50206
ERCC6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14064
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE208254_4_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BMAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6874
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF451	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32297
BRD-K62965224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33731
UNC5CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18209
BRD-K36737730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77306
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50603
KMT2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45417
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF653	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31701
BRD-K07534805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26426
BRD-K40057256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9537
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36554
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6153
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K46742113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07853
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71713
BRD-K54132860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09373
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1063
RBM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2319
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39567
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09858
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29567
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1374
BTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5642
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01224
BRD-K44705560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0799
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
BRD-K98201103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09349
WHRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31902
BRD-A55574211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45375
PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PAICS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29784
PMC8744330-13024_2021_507_MOESM2_ESM.xlsx-Table_S5-Supplementary_Table_5_The_conserved_3-layer_neighborhood_of_TP53_in_the_co-expression_networks_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39499927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84697
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26734
BRD-K97842654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82858
BRD-K58336011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58419
BRD-K03154735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56439
BRD-K34277236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44407
Primary progressive multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PAQR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26407
BRD-K62572662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54403
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM236B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47945
BRD-K30382953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1865
BRD-K78697404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29116
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K83276573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93773
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PCID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84639
ADISSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22793
BRD-K73831263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6157
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9133
AGAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10457
BRD-K37219127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30122
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73499
BRD-K75772626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28986
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	9.0061
BRD-K76829357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87674
BRD-K64859133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33447
BRD-K02473319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17096
BRD-K61388138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05119
RINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25799
UPF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86941
BRD-K39688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40684
HPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26922
CHAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21214
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.7976
GSE165174,GSE165175_0_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.009
BRD-K47599758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19846
BRD-K92444813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42205
BRD-K53199675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32291
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A99990159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36048
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66516
BRD-K72591075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86001
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LOXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34545
SLC25A34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69026
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.2182
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC12486367-Supplementary_Data2.pdf-182-TOPORS_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3571
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40919
RAB20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41139
BRD-K59955428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08724
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1242
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83885
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16484
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44289
HSPB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02094
BRD-K44103530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39072
MLLT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67673
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NR2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51023
BRD-K56106571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81721
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K88467167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06272
BRD-K78202004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28636
BRD-K83307202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20508
BRD-K43979194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46486
RARRES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18534
BRD-K86981519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15965
BRD-K09699976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01541
BRD-K62226454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27489
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
tRNA methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.863
BRD-K10705624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44815
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2542
drofenine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92216
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5095
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPIN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40965
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64571715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36319
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15582
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63936
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24350933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82505
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4071
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.2025
ZSCAN25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52128
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05109
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60484506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96099
NECTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15783
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3644
CRCGN015_MCF10A.WT.HP_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0647
BRD-K39476596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0081
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85357344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44609
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.0886
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5068
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
lysine N-methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16800391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39282
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4151
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Lsd1/2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67424
BRD-K28247259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30702
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
USP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37989
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48565
WBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36262
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.103
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16886
BRD-K83189379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19301
GBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92675
ZFPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51232
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70568
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44520987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85855
BRD-A42433574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39395
BRD-K16937802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9078
BRD-K95735171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16186
BRD-K24565713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67556
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34531548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28218
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0029
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.7447
BRD-K16542972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01768
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8142
FOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22387
STC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54158
MED27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70863
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5078
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K66879977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51724
BRD-A44046220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01397
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63800697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20614
BRD-K29661539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.62461
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03601
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GNPDA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08449
BRD-K05561348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21477
GSE164529_0_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17420784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10857
CSTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69405
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29131
BRD-K23664196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84182
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42636
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16861
GSE211128_9_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19106
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16357911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47192
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.42422
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22045035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21397
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7387553-41467_2020_17477_MOESM4_ESM.xlsx-B_LPS-stimulated_myeloid_cells-Cis-eQTLs_in_LPS-stimulated_myeloid_cells_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ABCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73351
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78305
BRD-A08820802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11319
LRRC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32714
STRADA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02117
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93734
BRD-K99971319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85077
BRD-K31372389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41001
GSE180304_3_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96604
BRD-K36884445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31751
BRD-K00804254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32449
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5199
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1827
FOXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81068
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.962
BRD-K66841501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1052
BRD-K59131688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78896
SETD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0742
BRD-K35923751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70595
PSMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25904
BRD-K36764776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07946
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01894
PSMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44909
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96995
BRD-K80816131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14355
BRD-K66145389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16721
BRD-K21927299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06565
GPALPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28686
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12132
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33861
BRD-K61053165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11775
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3639
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06444
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5513
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.01895
DENND4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35256
BRD-A48228341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21103
GALNT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15793
PMC8370976-41467_2021_24932_MOESM7_ESM.xlsx-Annotation-Supplementary_Data_5_GO_and_metascape_analysis_of_the_genes_upregulated_in_U87_cells_upon_ZNF768_knockdown_ZNF768	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52731958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07906
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81537454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36583
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327481
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31751
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KCNK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00196
496100382_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19777
FBXW9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.383
COQ5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3237
BRD-K20016759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10583
BRD-K62957665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04519
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.9744
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36135420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16477
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14778436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55264
BRD-K25638876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20396
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29732
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66409
TOR1AIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93333
NFE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58932
SPINDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03698
BRD-K04092807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59653
BRD-K21753319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27161
BRD-K71391283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77733
chr12_57782831_T_C_b38	GTEx eQTL 2025	1.0	2.81818
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21467089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09696
BRD-K66717300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21054
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25297
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5951
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42095
LAMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53817
BRD-K53319404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24372
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100660_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09867
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86600397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26848
BRD-K99221119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01676
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3308
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83805
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61544
BRD-K05409106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81114
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100663_TCx_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.96662
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A63759745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3201
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K81124412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20248
BRD-K98598055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12595
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239989
chr12_57750882_C_T_b38	GTEx eQTL 2025	1.0	3.24343
BRD-K23556321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39918
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-402-CCDC79_TERB1	Rummagene Transcription Factor Associations 2026	1.0	null
YJU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08257
BRD-K09521953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10093
Viral RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
PROM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14905
BRD-A90249268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29995
BRD-K91225366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0869
BRD-K96101240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57829
PMC10055465-media-2.xlsx-ST15-Supplementary_Table_15_Bonferroni-significant_results_of_MAGMA_gene_based_association_analyses_EA_-_p_2_67e-06_0_05_18702_genes_AA_-_p_2_63e-06_0_05_18976_genes_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31465
BRD-A20242387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13761
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94145457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38024
BRD-K30172718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75352
BRD-K25954314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29404
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36005
BRD-K31908823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3191
PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7584
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95941120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49881
RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.792
SOCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64157
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69119
RXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68812
BRD-K73872184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42918
BRD-K83966071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07589
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.533
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8298
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.18605
BRD-K46619710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85548
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K85664064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61075
BRD-K16214172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59063
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2958
ATR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15701
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03645
CRCGN017_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8838
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14675
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44917
BRD-K92776249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40387
EXOSC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95032
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28135
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5793
SURF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24453
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13352
BRD-K89320330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26239
GSE162015_1_v_0_nfkb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.417
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9729
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76725
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	2.27999
colo320hsr	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7699
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216859
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218043
BRD-K81751970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06089
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K81522184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34837
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27554804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39404
BRD-K78939372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30852
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26341
BRD-K84846130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19487
BRD-K29246335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39314
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21748
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74733
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06743
BRD-K63568016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13522
ATPAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48247
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00765
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.993
BRD-K23166347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82315
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GAL3ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42247
IL18BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2053
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86368
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6592
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9286
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF420	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35694
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1808
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7704
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98964
BAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61507
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8495
BRD-K59399000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90952
BRD-K28017317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99665
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30605
BRD-K05796207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16505
YTHDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13891
BRD-K86158100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55481
VEGFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32147
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3136
peptidyl-lysine methylation	GO Biological Process Annotations 2025	1.0	null
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2134
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91882
BRD-K18313650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41897
BNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78836
BRD-K06577881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.023
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1165
BRD-K16843478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27613
BRD-A60877539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45566
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9404
BRD-K91655763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09308
BRD-K61485947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00917
BRD-K04513994	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0379
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.22615
ARHGEF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87788
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.709
HSPBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23845
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chromosome	GO Cellular Component Annotations 2025	1.0	null
PMC11133462-41467_2024_47218_MOESM5_ESM.xlsx-IL-10_SBNO2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KLHL42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55057
Chondroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14589
BRD-K23062575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26604
BRD-A17741195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94284
PSKH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4165
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-A64523751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26456
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39578
BRD-K89853033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05162
BRD-K14269958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75355
SMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08495
OLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41588
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26314798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3318
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.0172
BRD-K23825243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07785
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.24692
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0477
BRD-K51363316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94428
BRD-K86358396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00734
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7111
UCHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25574
CNNM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0052
BRD-K37831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60283
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SERF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37184
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
BRD-K78311779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27146
MCM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51506
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.69397
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57388326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50904
TMEM130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50525
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15557
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28154
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6858
BRD-K18494310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62465
BRD-K83775558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19214
Transient neonatal diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3749
ZNF503	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37714
BRD-K39206254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03345
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81608755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49123
BRD-K32018176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38091