association	dataset	threshold value	standardized value
PDXK	Pathway Commons Protein-Protein Interactions	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LGMN	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA1L	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542315
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360604
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.823
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mRNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
hsa-miR-30b	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
BRD-K59670689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57777
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.24905
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59031
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0118
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23009
(+/-)-catechin-4837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MOV10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
positive regulation of cell proliferation	GO Biological Process Annotations 2015	1.0	null
H3K36me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCCC2	Pathway Commons Protein-Protein Interactions	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01442
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.215
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.97193
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.03382
Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.29924
single organism reproductive process	GO Biological Process Annotations 2015	1.0	null
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U118	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09708
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.843377
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.505187
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2478
IGHG2	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1993	DepMap CRISPR Gene Dependency	1.0	10.302
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-6609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.701025
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350059
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17026
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45759
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70448
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0973
MYO1B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MON	DepMap CRISPR Gene Dependency	1.0	3.43658
GSE139948_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34095
protein binding	GO Molecular Function Annotations 2015	1.0	null
J82	GDSC Cell Line Gene Expression Profiles	1.0	1.621
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PDIA6	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68822
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90602
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11201
KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.94888
BRD-K38350115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61166
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5232
regulation of cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K54478142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33159
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.91542
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70965
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83218
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RY-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral septal nucleus, caudal (caudodorsal) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55727
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM12	CCLE Cell Line Gene Mutation Profiles	1.0	null
EEF1A1P5	Pathway Commons Protein-Protein Interactions	1.0	null
acetylsalicylic acid-5564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
D-245MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K53257131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07653
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00742
Perturb_11901_KO_Irf8_SRP265303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39558
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K66222602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1265
hsa-miR-3923	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRRM2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03881
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62346
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.93014
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC44	CCLE Cell Line Gene Expression Profiles	1.0	1.41975
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60487
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-16	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50475
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU475	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63334
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12116
BRD-K32199799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17191
Adenoma	DisGeNET Gene-Disease Associations	1.0	null
8759_TBX5_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536712
ChIP_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
iopamidol-2732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thalidomide-7288	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RUSQ-0426-SM-47JWR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867936
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-1197	GDSC Cell Line Gene Expression Profiles	-1.0	-2.43825
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
effect	GeneRIF Biological Term Annotations	1.0	null
SQSTM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE115763_3_v_1_klf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213099
ALKBH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52623
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPI1	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900632
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5977-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MSH6	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H1T	Pathway Commons Protein-Protein Interactions	1.0	null
DCD	Pathway Commons Protein-Protein Interactions	1.0	null
aggressiveness	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06025
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31072
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840699
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4668-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.7796
Chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47103
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2ML-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21287
Perturb_3690_KD_NUF2_SRP352847	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67541
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28919392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23827
hsa-miR-140-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.936961
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11840074-41467_2025_56848_MOESM13_ESM.xlsx-Sheet1-Data_S10_Correlation_of_HIF_target_genes_with_AS-NFKB1_and_canonical_NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
NUP214	Pathway Commons Protein-Protein Interactions	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32026
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6821
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77836949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00384
KAT2B	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4453
RXF393	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TE6	CCLE Cell Line Gene CNV Profiles	1.0	1.66707
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.33524
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65415
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11216
UBE2L3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74133
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KRT14	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UA-06-UV98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317832
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81931105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16701
AKT1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09294
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73066
Silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_BOUND_BY_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.982331
PRPF38B	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153189_1_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2342	CCLE Cell Line Gene CNV Profiles	1.0	1.48176
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STRBP	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Zafirlukast	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05402
Cytochrome b6f complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.7
Prostate adenocarcinoma_PRAD_TCGA-G9-6364-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8294
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09492
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43722
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
Prestwick-1100-3880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDOST	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GM2313	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93472147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59647
BRD-K56645451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.507
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03315
rna transport	GO Biological Process Annotations 2015	1.0	null
Perturb_9209_KO_Cic_SRP076421	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.8516
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24312
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064665
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.95952
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499446
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.29395
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66465
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STK4	Pathway Commons Protein-Protein Interactions	1.0	null
SSR4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
benzylpenicillin-6839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Breast_vHMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.34792
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5635
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Microspore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
organelle part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11705
TT	CCLE Cell Line Gene CNV Profiles	1.0	1.37635
Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.636
BRD-K17751525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34774
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85611
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.188274
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905401
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3760_KD_TSG101_SRP325061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.0298
CCDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71602
transport	GO Biological Process Annotations 2015	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.0
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32906083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86466
BRD-A69110666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09497
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48594
CEP85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35077
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HB-75-KT12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262628
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Taproot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82397896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12811
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5149-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
IQGAP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918328
hsa-miR-3919	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23081
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKNAS_AUTONOMIC_GANGLIA	CCLE Cell Line Proteomics	1.0	2.11134
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883802
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.8439
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8430-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34113
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00573
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cancers	GeneRIF Biological Term Annotations	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52615
BRD-K78403457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28875
hsa-miR-544	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48922
Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.45
mephenesin-3675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Non-Small Cell Lung Cancer	DisGeNET Gene-Disease Associations	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846696
dizocilpine-6223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25725
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_8_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25042
BRD-K19776718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37616
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59680547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0691
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03813
VDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373868
MAPK1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59095205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37217
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE124304_1_v_0_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-AH-6643-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88492
KD	DepMap CRISPR Gene Dependency	1.0	2.0871
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64247
hgc-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05853
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.1958
Basket cell_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3755_KD_RNF40_ERP110773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ESS1	CCLE Cell Line Gene Expression Profiles	1.0	1.43351
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	1.8183
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60968
hsa-miR-3118	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49709
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73840377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10226
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842042
BRD-K61079130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3827
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81678
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.736
KRT6B	Pathway Commons Protein-Protein Interactions	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890666
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.750596
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04477
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6074
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_7_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95688
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.83906
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92778
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66128
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02092
AHCY	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11666_KD_PTBP1_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.97789
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4127
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376606
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64695
GTEX-RTLS-2626-SM-46MUJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23619
Carbamazepine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
haloperidol-1669	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
karakoline-2203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880479
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863516
urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.161912
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.63645
KH-CB19	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.69
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06284
clidinium bromide-2734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PPP1R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6871
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75325
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K19492738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19311
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16554464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07646
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7229-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05357297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13926
Ac-YVAD-CHO	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.48
Rectum adenocarcinoma_READ_TCGA-EF-5831-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACCMESO1	CCLE Cell Line Gene Expression Profiles	1.0	1.52653
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.483224
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24743
NCI-H358 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKCZ_KO_GDS4310_293_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
Acetazolamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NME1	Pathway Commons Protein-Protein Interactions	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328065
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863516
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
JVM-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64013
BRD-K06719105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12344
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HNRNPUL2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35418
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.91
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A268-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1906
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.337608
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.25324
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64840743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14479
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973975
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-689-7173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904159
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51265
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12007
pharyngeal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106524
Nitisinone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.19
Hypusine synthesis from eIF5A-lysine	Reactome Pathways 2024	1.0	null
pioglitazone-7528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55895
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12027
USF2_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.65853
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086817
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06512
Stage Iia Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
macromolecule biosynthetic process	GO Biological Process Annotations 2025	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1492
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K96254487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16566
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XRN2	Pathway Commons Protein-Protein Interactions	1.0	null
Rat-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.62
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z3-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931666
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleic acid transport	GO Biological Process Annotations 2015	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.803205
Hyperplasia	CTD Gene-Disease Associations	1.0	1.27626
KDM1A	ENCODE Transcription Factor Targets	1.0	null
acquisition	GeneRIF Biological Term Annotations	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893405
hsa-miR-4324	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223662
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961398
BACH1	ENCODE Transcription Factor Targets	1.0	null
GSTP1	Pathway Commons Protein-Protein Interactions	1.0	null
vanoxerine-3240	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
tranexamic acid-5762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.868
econazole-6008	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Laryngeal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.447
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10385
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus-1667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral hypothalamic area, tuberal part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.881439
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.269753
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11681
BRD-K80577041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21173
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43334
TPR	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26852477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39986
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2294
zona incerta	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00534
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Esophageal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.823
HDAC6	ENCODE Transcription Factor Targets	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.979409
BRD-K08527280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07051
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54811
H2AK5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hepatocellular	GeneRIF Biological Term Annotations	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyramidal cells of caudal CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.93739
MFE-280	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL1777 (C21orf7)	NURSA Protein Complexes	1.0	null
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.321685
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36507
CEBPB_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDST8	CCLE Cell Line Gene Expression Profiles	1.0	2.22548
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.98
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2585
PMC12508431-44319_2025_552_MOESM1_ESM.xlsx-Table_EV1-Table_EV1_EWS_FLI1_sensitive_gene_targets_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.317
Magnesium chelatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.544
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45335
H3K27me3_iPS-15b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-320b	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836159
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44260904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52283
RCN2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-NFATC3_mod_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826628
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998033
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206374
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0729
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BLOC1S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19916
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
HCC1897	CCLE Cell Line Gene CNV Profiles	1.0	1.68567
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46598
hsa-miR-106b-5p	MiRTarBase microRNA Targets	1.0	null
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91577886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42231
Grey cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
trioxysalen-5736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFON-1126-SM-4LVMA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50936
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54667
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26485
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92736140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7715
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.65208
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952453
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4740-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Iclaprim	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
JAR	DepMap CRISPR Gene Dependency	1.0	3.8659
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.555
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estrogen-receptor negative breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.36635
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43969
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38134
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54414
GSE128634,GSE128636_4_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_Fetal Heart	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.022
SUZ12-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
methyldopa-3234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39648
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56427
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03677
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
RBM22	Pathway Commons Protein-Protein Interactions	1.0	null
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07438
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14529
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04864
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_11_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
DUT	Pathway Commons Protein-Protein Interactions	1.0	null
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-6655-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1269b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85267
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
time	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4742-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51006
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513399
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Recurrent Tumor	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2145
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34998
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263327
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.33806
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.636
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55237
MAFK	ENCODE Transcription Factor Targets	1.0	null
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955727
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
LY334370	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
hsa-miR-30e	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6517-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
protein transport	GO Biological Process Annotations 2015	1.0	null
NPC	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.337
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19674
ribonucleoprotein complex binding	GO Molecular Function Annotations 2015	1.0	null
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACADM	Pathway Commons Protein-Protein Interactions	1.0	null
NC-27-AD53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253945
MAP7D1	Pathway Commons Protein-Protein Interactions	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	6.97862
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490913
Gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.452198
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305891
Ulipristal	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10475
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACSM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34952
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06173
Oral squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
LY 344864	DeepCoverMOA Drug Mechanisms of Action	1.0	0.88
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
than	GeneRIF Biological Term Annotations	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477216
Stage Iv Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63303
Eukaryotic translation initiation factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.694
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-0.969415
hsa-miR-1284	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PA-A5YG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08238
hsa-miR-580	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065756
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14421
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86128
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877541
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06342
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.461019
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skmel31	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.181
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00496
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44265418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51239
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204249
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01159
NHLF	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.76259
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02596
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNRPB	Pathway Commons Protein-Protein Interactions	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16323
GSE75976_3_v_9_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17364_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.4386
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNUC4	CCLE Cell Line Gene Mutation Profiles	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319684
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06907
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619069
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76141
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00649
USF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830102
5253409-844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0473
azlocillin-6262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5997
STBD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1612
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8261
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3425
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
died	GeneRIF Biological Term Annotations	1.0	null
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.733
stomach	HPA Tissue Gene Expression Profiles	1.0	1.50144
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.950378
EZR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_0_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4502	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SKOV-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.195
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72141
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149760_0_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.81569
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nuclear pore	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GMNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43848
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78408
BAG4	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPCL1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.837044
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.43836
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLT-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.86364
Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75I-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6474_PMF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663131
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2704
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07655
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ronidazole-3557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP1A1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88494268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08143
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chloroplast ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.995
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN_01_172	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.0381
hsa-miR-3150a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K11666748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22832
initiation	GeneRIF Biological Term Annotations	1.0	null
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.256234
GYG1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70062
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.23265
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26791
BRD-K30782795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1754
ELF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5365-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.622527
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
BRD-K95016030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64699
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209539
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974468
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KRT27	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.685147
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.795735
stimulating	GeneRIF Biological Term Annotations	1.0	null
JUN_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EXOSC2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28446462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28408
RPMI-8226	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58155
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
protein localization	GO Biological Process Annotations 2015	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39531
GEMIN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06621
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KRT71	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30077
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
GSE193993_1_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81628
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.60847
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.892051
Gall bladder cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.897033
CP-645525-01-7522	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15504
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-397-SIX3_AS1_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181966_0_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LIN28B_01_153	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.09432
G3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	90.0128
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56147
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Phosphatidylinositol 3-kinase complex, class IB	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.711
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50626
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.504575
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25239
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227014
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968997
BRD-K50177754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51603
Medulloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.149
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03813
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32718856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95691
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2304
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
pore complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-3566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06457
hsa-miR-192	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
EIF2S3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46815
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83028
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.57311
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913683
GFAP	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR22	CCLE Cell Line Gene CNV Profiles	1.0	2.74316
RIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13489
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
Papillary thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53768630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85268
terbutaline-3202	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
molecular	GeneRIF Biological Term Annotations	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
Olodaterol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02583
SW-1116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366376
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ALDH3A2	Pathway Commons Protein-Protein Interactions	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.966417
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
rosiglitazone-6192	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30922
TMEM160	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.38552
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ML-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
Somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68131
SERPINB13	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5495-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFEB-21752829-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
cd8 cells	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
PMC3910540-725780.f1.xlsx-Table_S5-MYC_target_genes_in_human_ES_cells_Ji_Wu_et_al_2011_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38912
cc81	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84726
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-561	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.892873
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-30d	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-25-3p	MiRTarBase microRNA Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3786
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303559
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26932
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25983
organelle part	GO Cellular Component Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5701-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13456
anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.91725
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863516
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07878
GABARAPL1	Hub Proteins Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826521
hsa-miR-382	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
translation	GO Biological Process Annotations 2023	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.06501
PMC7481169-277_2020_4194_MOESM7_ESM.xlsx-RUNX1_R139G-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.951139
RPS20	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11389666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27061
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26655
primary auditory cortex (core)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.842574
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03182
Perturb_492_KO_LITATS1_SRP363523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042544
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
pridinol-7214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
stomach	GTEx Tissue Gene Expression Profiles	1.0	0.953785
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.887157
clobetasol-6835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Squamous Cell Carcinoma Of Esophagus	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32023
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.19194
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913557
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67866
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100369_PCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50518
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08818
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04609
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941642
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03513
Eukaryotic translation initiation factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.656
BRD-K01606969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57822
EIF2S2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H727	GDSC Cell Line Gene Expression Profiles	-1.0	-2.159
BRD-A47137250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3174
epirizole-7292	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.882778
BCKDHA	Pathway Commons Protein-Protein Interactions	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.042
BRD-K37457040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88136
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
latter	GeneRIF Biological Term Annotations	1.0	null
GSK-LSD1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
alfadolone-7262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IMR32	DepMap CRISPR Gene Dependency	1.0	3.04226
Bradyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31782
GTEX-X4XY-0326-SM-46MVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9226
PRPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4103
hsa-miR-4670-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
r3 part of the trigeminal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15691
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991548
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57935
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18208
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37667
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-20a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4553
Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06173
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55977
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.85388
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BQ-788	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.60161
ARID1A_01_108	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.92895
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.56057
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17482
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zeta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
PSMB2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A47416464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07462
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05350978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22242
BRD-K61213827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55421
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.852426
nuclear part	GO Cellular Component Annotations 2015	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83371
HCC1569	CCLE Cell Line Gene Mutation Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
GSE130401_4_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
EE-77-XO60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259832
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CALR	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY-294002-1652	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06641
aminophylline-5395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PABPC4	Pathway Commons Protein-Protein Interactions	1.0	null
RXF393	GDSC Cell Line Gene Expression Profiles	1.0	1.57646
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63985
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82382
Perturb_12233_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Activin AB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.985
olfactory tubercle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36553
u698	HPA Cell Line Gene Expression Profiles	1.0	0.86155
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28555
MUC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66956
PF-04620110	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
SRRT	Pathway Commons Protein-Protein Interactions	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.196
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.214636
NB1	DepMap CRISPR Gene Dependency	1.0	5.45842
LY-294002-6995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891303
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07437
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.996883
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11633_KD_IFNA17_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7402
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53074
Lung squamous cell carcinoma_LUSC_TCGA-18-4721-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.682833
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17236
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.904728
CHEMBL383736	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
translation elongation factor activity	GO Molecular Function Annotations 2015	1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414609
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53715
ALDH9A1	Pathway Commons Protein-Protein Interactions	1.0	null
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
MERO14	DepMap CRISPR Gene Dependency	1.0	6.69702
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IGKV1-5	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mianserin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458905
Perturb_12701_KO_Anxa5_SRP379319	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.71737
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.014
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.910691
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25818
exon-exon junction subcomplex mago-y14	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
hsa-miR-20b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE149760_3_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IRS4	Pathway Commons Protein-Protein Interactions	1.0	null
gelsemine-2162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DYRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07089
current	GeneRIF Biological Term Annotations	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
pimasertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75102
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATG4B	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJC10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46841
BRD-K18930370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15162
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4117-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7083
GSE217685_0_v_1_ddx20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.2463
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epithelial ovarian cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34252
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	2.2716
hsa-miR-130a	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Triple-Negative Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-S4UY-1626-SM-4AD55	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2348
MAP1B	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.17912
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
trigeminal	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46788
hydrochlorothiazide-4970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NEK9	Pathway Commons Protein-Protein Interactions	1.0	null
SK-OV-3	GDSC Cell Line Gene Expression Profiles	1.0	1.70675
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sulfamethoxypyridazine-3409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79946769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39732
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55988
BRD-K73768826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17189
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
UMUC13	DepMap CRISPR Gene Dependency	1.0	4.09842
macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K9me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K16479784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25846
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06173
MYH14	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.509813
Chromoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
Acute Myeloid Leukemia_LAML_TCGA-AB-2808-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF2B4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4204_KO_Top1_SRP072888	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.11403
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052573
Tongue	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.998006
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
F8	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DOCK7	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23522
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Reactome Pathways 2024	1.0	null
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057938
EKVX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36614
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6580320__F1	PFOCR Pathway Figure Associations 2023	1.0	null
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53505
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28681
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991184
BRD-K53643174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19971
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RASA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16272
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
R-atenolol-4841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SRSF10	Pathway Commons Protein-Protein Interactions	1.0	null
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8182
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23846
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52549
BRD-K90675978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09635
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTAP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8843_KD_PPARGC1B_SRP254908	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
thapsigargin-7053	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-30c	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATG4A	Pathway Commons Protein-Protein Interactions	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
Extrachromosomal circular DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.051
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.997604
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PKP1	Pathway Commons Protein-Protein Interactions	1.0	null
peptidyl-amino acid modification	GO Biological Process Annotations 2015	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960838
DLAT	Pathway Commons Protein-Protein Interactions	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
contains	GeneRIF Biological Term Annotations	1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K55044152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22242
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
BRD-K03331449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88914
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261135
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254146
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
mephentermine-3685	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0372
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29563
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.767
Perturb_3706_OE_Hif2a_SRP316426	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.4089
Perturb_14541_KD_MTHFD2_SRP287895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
dohh	GeneRIF Biological Term Annotations	1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
iobenguane-7299	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.029271
hsa-miR-218	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15275
hsa-miR-4419b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26297
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
ATG7	Pathway Commons Protein-Protein Interactions	1.0	null
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	2.42333
GSE192771_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14183
GTEX-XMK1-0008-SM-4GICF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05909
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32474
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91387865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20234
5720_NMT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501211
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16971
BRD-K29509140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32653
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
ANK2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.02638
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12234_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49655
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Autosomal dominant distal hereditary motor neuronopathy 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
3-isopropylmalate dehydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7501-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.53279
BRD-K94962942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39415
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.890237
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF3A1	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11746
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.128
mechanisms	GeneRIF Biological Term Annotations	1.0	null
ciprofibrate-5740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD320	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19729
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAJC7	Pathway Commons Protein-Protein Interactions	1.0	null
Ralfinamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
Perturb_12196_KD_ERCC5_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30695
NFKB1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4256
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08714
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PPP4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10971
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cysmethynil	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
ribosomal	GeneRIF Biological Term Annotations	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6848-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
SNRPG	Pathway Commons Protein-Protein Interactions	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
r3 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16971
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13586
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urothelial	GeneRIF Biological Term Annotations	1.0	null
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
lateral portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.898424
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09225
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46539
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC10623707-13148_2023_1590_MOESM5_ESM.xlsx-S5A_EW-GE_MR-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
esophageal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.151114
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
RARRES1_KD_GDS4818_314_human_SUM149	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ChIP_SALL4_18804426	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.681894
EGFR_druginhibition_82_GSE27638	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.49523
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264988
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.53346
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2995
BRD-K59709341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15154
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.63035
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21975
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
estradiol-5238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outcome	GeneRIF Biological Term Annotations	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.6663
CREM	ChEA Transcription Factor Targets	1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9473
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.979502
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57436
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4776-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
lateral medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.986569
S107	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
RAB30	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
core of nucleus accumbens	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22937
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-628-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
HCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89149
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248683
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.896
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
establishment of rna localization	GO Biological Process Annotations 2015	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9039
GTEX-T8EM-0526-SM-4DM64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07073
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.419623
PMC11376028-13578_2024_1300_MOESM1_ESM.xlsx-CCF_2nd_round-SYMBOL_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
SW1573	CCLE Cell Line Gene Expression Profiles	1.0	1.72652
PSMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44909
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.993503
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06632
JMSU1	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K78162975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37142
GSE210682_0_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
trichostatin A-4458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5516-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endosperm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44O-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12207_Mut_TP53_SRP287851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.38288
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15179_KD_AIM2_SRP404341	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.39981
SW1990	CCLE Cell Line Gene Expression Profiles	1.0	1.36981
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
S100A9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971713
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77536
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.83376
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39316
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
GSE199874_3_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOP92	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
ATF3	ENCODE Transcription Factor Targets	1.0	null
translational frameshifting	GO Biological Process Annotations 2015	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.867
GSE189859,GSE189861_3_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.488
common	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2901-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2_Deficiency_GDS4853_322_human_AZ-521 gastric cancer (GC) cell line - 24 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
r3 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23185
SKRC31	CCLE Cell Line Gene Expression Profiles	1.0	1.47204
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996026
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25567
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Laryngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62N-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPAN-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33587
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.938071
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lung adenocarcinoma_LUAD_TCGA-69-7978-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF2	ENCODE Transcription Factor Targets	1.0	null
Chlorenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08339
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085959
CUL4B	Pathway Commons Protein-Protein Interactions	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.84563
Gigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02261
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15169
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49373
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88890050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84074
Nthy-ori 3-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
M14	GDSC Cell Line Gene Expression Profiles	1.0	1.79633
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99561
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.680748
Pith	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19429
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_3-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.85303
POSTN_01_293	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58497
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15504
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02344
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	1.58392
HIST1H1A	Pathway Commons Protein-Protein Interactions	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
esr1_21299862_mcf7_lof_human_gpl570_gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.149797
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66671
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12209
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.626195
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K74251295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05679
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29157
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240878
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979603
vitamin c_mus musculus_gpl6246_gse19378	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HEL	DepMap CRISPR Gene Dependency	1.0	3.66016
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257997
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44336
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
regulation of translational termination	GO Biological Process Annotations 2015	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SNU423	CCLE Cell Line Gene Expression Profiles	1.0	1.59865
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08656
MYO1C	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Methyl coenzyme M reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.684
NCIH23	CCLE Cell Line Gene CNV Profiles	-1.0	-2.78744
triamterene-7307	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K82224868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40323
Inflammation	CTD Gene-Disease Associations	1.0	1.54281
advanced	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3671	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
GSE51684,GSE51741_2_v_4_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal stromal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04862
BRD-K35196805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20187
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350743
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
methotrexate-6654	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2843
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3761_KD_VPS28_SRP325061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.35753
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975702
Perturb_14123_KD_Fus_SRP182046	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.49151
NCCLMS1C1	DepMap CRISPR Gene Dependency	1.0	2.67287
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Amplified_upregulated_genes_B_identified_as_synthetic_lethal_with_gene_A_deletion_downregulation_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42641
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165174,GSE165175_0_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
DIFI	DepMap CRISPR Gene Dependency	1.0	2.85163
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38248920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18974
hsa-miR-548n	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47419
KRT6C	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19699893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39383
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
stratum pyramidale of caudal CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28439
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.08455
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957269
Eukaryotic translation initiation factor 4F complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.324
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079977
GPR150	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46097
SNU387	DepMap CRISPR Gene Dependency	1.0	4.10696
FYCO1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41116634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58725
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EM-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78571
icSARA deltaORF6_7Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.68234
BHLHE40_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cmyc	GeneRIF Biological Term Annotations	1.0	null
DLD	Pathway Commons Protein-Protein Interactions	1.0	null
SW480	CCLE Cell Line Gene Expression Profiles	1.0	1.37265
hsa-miR-3647-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97423
eif5a1	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7868
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.909055
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09005
transition	GeneRIF Biological Term Annotations	1.0	null
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6989-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03593
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
myosmine-2199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3	ChEA Transcription Factor Targets	1.0	null
U2OS	CCLE Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5370-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65538
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-7-5p	MiRTarBase microRNA Targets	1.0	null
RPL27	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_16944_OE_Snca_SRP280164	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.843
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7952
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03808
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58977196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.324
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Nasopharynx epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mesoridazine-7017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75527
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19973
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0032
Rectum adenocarcinoma_READ_TCGA-DC-4745-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.188274
Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT76	Pathway Commons Protein-Protein Interactions	1.0	null
posttranscriptional regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37613
nucleolus	LOCATE Curated Protein Localization Annotations	1.0	null
radical	GeneRIF Biological Term Annotations	1.0	null
PMC10592962-media-4.xlsx-OC2_genes-gene_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
18413728-Table2a	GeneSigDB Published Gene Signatures	1.0	null
trichostatin A-2993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell property	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06954
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JA-26-YQ32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284725
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUP210	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98891210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44553
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9132
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00771
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25239
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
SLAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45114
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02301
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
aceclofenac-7029	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
mkn-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.54343
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.44905
hsa-miR-4496	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35006
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CW9019	DepMap CRISPR Gene Dependency	1.0	3.57104
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
bezafibrate-2630	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TD-69-UA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.413914
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34588
BRD-K90877053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06532
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06365
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956742
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839419
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45620289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67987
esophageal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.667622
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gliquidone-7301	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
encode	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-27a	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5597
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16635
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057982
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4122406-pone.0104158.s010.pdf-24-EHF_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70756
BRD-K08881846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42573
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881701
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SARS-CoV MA15_Day4-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.90804
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADGRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04875
r7 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14072
BRD-K47620421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18071
HCC827_LUNG	CCLE Cell Line Proteomics	1.0	5.05811
cefotaxime-5830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11054031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28877
regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08293
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81905
KRT13	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0426-SM-3NM9H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953722
Lung squamous cell carcinoma_LUSC_TCGA-33-4586-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858003
non-small cell lung adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.545739
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
cinchocaine-4068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50269
lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.38439
man	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4728-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
piperacetazine-7191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skpndw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
POLR3A	ENCODE Transcription Factor Targets	1.0	null
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ribosome binding	GO Molecular Function Annotations 2015	1.0	null
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.87
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0501
Infertility, Male	HuGE Navigator Gene-Phenotype Associations	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
interleukin-23 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.175188
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058968
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19658
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	157.261
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51641
RUNX3	ENCODE Transcription Factor Targets	1.0	null
ncih1650	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.905
Bladder carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65538
overexpressed	GeneRIF Biological Term Annotations	1.0	null
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
ovarian	GeneRIF Biological Term Annotations	1.0	null
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76664579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05602
Ovarian Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Nasopharyngeal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.49735
isoxicam-1820	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GRB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02321382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33675
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66045
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	2.25556
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5966-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05868
BRD-K54650634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.13542
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089595
Liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.914
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4314_KDELR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609573
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.621
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.939
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_3H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03997
cyclopenthiazide-7325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44944875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55804
MTF2	ChEA Transcription Factor Targets	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977765
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6879-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TALDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64945
gamete generation	GO Biological Process Annotations 2015	1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chloroplast ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.869
carcinomas	GeneRIF Biological Term Annotations	1.0	null
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24774
BRIX1	Pathway Commons Protein-Protein Interactions	1.0	null
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
HULC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVSAHO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.946
Medial amygdalar nucleus, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25707
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.999852
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.60824
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0085
ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.43941
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38082
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRPX	Pathway Commons Protein-Protein Interactions	1.0	null
YTHDC2	Pathway Commons Protein-Protein Interactions	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56248
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08738
RRP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-76-HU27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255348
BRD-K19011391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73657
hsa-miR-215	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF254_01_127	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61886
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GSE138024_2_v_3_rgs4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4538-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_7Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.30879
Acute Myeloid Leukemia_LAML_TCGA-AB-2867-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
YLPM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07770425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17598
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13257
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0396
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06878
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907705
hsa-miR-31	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
group	GeneRIF Biological Term Annotations	1.0	null
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SETDB1-19884255-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Unnamed_2_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
lysergol-3261	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
GTEX-OOBJ-1526-SM-3NB1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39893
Bosentan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.65
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70886
metastasis	GeneRIF Biological Term Annotations	1.0	null
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5041
posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18522
5928_OGFOD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593402
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943371
OCILY10	CCLE Cell Line Gene Mutation Profiles	1.0	null
Thiazole synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.966
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13445
PRRC2C	Pathway Commons Protein-Protein Interactions	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11848
LC1F	CCLE Cell Line Gene CNV Profiles	1.0	1.50941
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18574
ChIP_TCF3_18467660	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03352
fluphenazine-1662	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61138
PMC3639976-pone.0063011.s017.xls-DataFrame-Dataset_S3_Microarray_analysis_of_HeLa_cells_treated_with_si-PPARD_in_the_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07475
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383769
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961677
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04748
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
peptidyl-lysine modification	GO Biological Process Annotations 2015	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041974
PMC10591836-NIHMS1933909-supplement-6.xlsx-Fig_6C_overlap_between_KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9576445-IJG2022-9264555.nxml--Potential_targets_of_hsa-miR-16-5p_AND_hsa-miR-184_NOT_hsa-miR-15b-5p_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
pore complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13959
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-387 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941725
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44714
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
127_ADAM10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604757
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
colecalciferol-2436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4659a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
PMC4224449-pone.0112193.s009.xlsx-PPI_MODULES_CLEAN_MAP_merg_OUT-Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83708628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44568
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49217
LIME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06424
atractyloside-3435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916155
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09758
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
genistein-6952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27095
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8089-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE236815_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.5817
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
tanespimycin-1631	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880479
RBMXL2	Pathway Commons Protein-Protein Interactions	1.0	null
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092855
XPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72455
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03526
Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BASP1	Pathway Commons Protein-Protein Interactions	1.0	null
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-570	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840989
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995058
GSE96991,GSE97117_5_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0396
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	47.6745
Ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82882
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
azathioprine-1528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WDR11	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
RPL13A	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PWP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2109
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382506
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-221	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9301
BRD-K86373784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28921
PMC6283862-41388_2018_370_MOESM14_ESM.xlsx-NANOG-NANOG_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.033228
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84724
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35037
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5524-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29086754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08437
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Prestwick-685-4705	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
dobutamine-3206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nasopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225642
Perturb_16637_KO_Drd2m_SRP377988	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.84881
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CSNK2A2	Pathway Commons Protein-Protein Interactions	1.0	null
SPINT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19458
BRD-K76210487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06917
hsa-miR-9	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983364
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eif5a	GeneRIF Biological Term Annotations	1.0	null
BRD-K44078665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78452
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
Prestwick-1084-7125	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKT2_knockdown_44_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.52365
HSPE1	Pathway Commons Protein-Protein Interactions	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2163
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040195
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.85942
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_N1-GOPC_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_4_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3173-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246576,GSE246826_0_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839974
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22189453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22447
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1706
SFT2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03196
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
JA-88-IO52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298196
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QB-34-NU46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216608
REST	ENCODE Transcription Factor Targets	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74681
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_30Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.56765
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48602
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06093
MAX_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97553
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67391
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
other	GeneRIF Biological Term Annotations	1.0	null
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
SNU503	CCLE Cell Line Gene CNV Profiles	1.0	1.6657
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446917
KRT2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60166659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53628
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22678
artemisinin-7007	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.119
lomefloxacin-3723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
F5	DepMap CRISPR Gene Dependency	1.0	4.56145
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A89554862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41221
WM88	DepMap CRISPR Gene Dependency	1.0	2.05248
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961398
RBBP6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45350681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25918
hsa-miR-571	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
Kidney Chromophobe_KICH_TCGA-KN-8424-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
terfenadine-6823	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25943
BRD-K16621460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00871
translational elongation	GO Biological Process Annotations 2015	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.860729
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K47881755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35337
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7468
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11263
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78958
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stage, Cervical Cancer	DisGeNET Gene-Phenotype Associations	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.23666
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.03595
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LYAR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6496
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6023-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MB-49-LL22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22642
haloperidol-6163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ8I-2026-SM-4BOOL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959236
NCOA5	Pathway Commons Protein-Protein Interactions	1.0	null
SP in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.953365
u2197	HPA Cell Line Gene Expression Profiles	1.0	1.29997
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_49_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
HEC251	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45563993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00897
EGFR_drugactivation_20_GDS2146	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63475
rearrangement	GeneRIF Biological Term Annotations	1.0	null
CAL-39	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5591-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35035851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09776
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
Tezacaftor	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
11-deoxy-16,16-dimethylprostaglandin E2-7519	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_287_KD_JMJD6_SRP334376	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.97449
hsa-miR-4252	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
NCI-H1299 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
SEC24B	Pathway Commons Protein-Protein Interactions	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.868217
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11338
PSMA6	Pathway Commons Protein-Protein Interactions	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37615
SETDB1-19884255-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.123
MM1S	DepMap CRISPR Gene Dependency	1.0	3.79259
GSE103124_2_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CKB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940776
hsa-miR-1304	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
RBM34	Pathway Commons Protein-Protein Interactions	1.0	null
RAB33B	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40322
BRD-K66511507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89058
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5958
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MKN-45 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
BRD-K60905563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26578
hsa-miR-4439	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
beta-escin-2194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-TFAP2A_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966725
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3568013-1471-2105-13-128-S6.xls-NME2-Unnamed_15_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17405
sample	GeneRIF Biological Term Annotations	1.0	null
BRD-K65399214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05632
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.859708
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54691
KDM4A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5025
BRD-K32723442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32608
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.64148
SNU-449 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.882
PMC8802127__F7	PFOCR Pathway Figure Associations 2024	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14002
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.78493
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07397
DAOY cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.319
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ncoa_22072566_ly2_lof_human_gpl570_gds4095	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	2.22133
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26854
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16308
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6771_PRKRIP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.569631
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUP	Pathway Commons Protein-Protein Interactions	1.0	null
difenidol-7447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8323-01A-21R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.18952
hsa-miR-4319	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
BRD-K41700289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13155
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06373
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16089
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKCO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39701
Perturb_9657_KD_NKX25_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HSP90AB2P	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
esculin-5411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WW-01A-22R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19764912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34308
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32205
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CBR3	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.829604
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9807
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51227
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RH-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
gastric adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.285802
332_ANKRD17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605566
hsa-miR-93	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3876
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.965964
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.882465
liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.504207
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8052
NR3C1	ENCODE Transcription Factor Targets	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06173
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.873491
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853605
Hypopharyngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85813125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.03322
Lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20315
Translation elongation factor, IF5A, hypusine site	InterPro Predicted Protein Domain Annotations	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341648
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGAM2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20739
Perturb_15241_KD_ERCC6L2_SRP349996	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.84661
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44402256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.301
gastric cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.259254
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13011
GAMG	CCLE Cell Line Gene Expression Profiles	1.0	1.38758
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_chimp_DRSG_higherRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232039
ribostamycin-7123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFG	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
thioridazine-1655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11031937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49342
BRD-K35588268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48754
Mesothelioma_MESO_TCGA-LK-A4O0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Perturb_123_KD_Fto_SRP314220	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.7592
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
19139136-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21127
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.371467
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
astemizole-4471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Post-translational protein modification	Reactome Pathways 2014	1.0	null
betulin-3513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SRP9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42317
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
ovarian carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.442418
Nasopharyngeal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11757577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20096
protophloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179259
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.871597
GTEX-QDVJ-0726-SM-48U1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843393
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51511
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3KJ-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83597
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4461	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251187
pilocarpine-2438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3950_KD_BTF3_SRP288228	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.95691
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVJ-0626-SM-48U1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881499
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896241
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15656903-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
PMC10828394-41698_2024_509_MOESM1_ESM.pdf-55-EBF4_EBF4	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09842
GYS1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nuclear matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.112
BRD-K21423050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14008
TALL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39658
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70636
GSE90821_3_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09027
BRD-K96969336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09677
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-1227	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
PDCD6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878972
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vidarabine-3445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232039
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.352
isoniazid-7197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01727
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
USF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGAM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96459367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94013
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72164
Lung squamous cell carcinoma_LUSC_TCGA-58-A46M-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3143	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00955
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_14_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
vigabatrin-2452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPH	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16308
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.64061
TAF7	ENCODE Transcription Factor Targets	1.0	null
HNRNPUL1	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850166
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45121
BRD-K97617600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94259
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6293
NCIH3255_LUNG	CCLE Cell Line Proteomics	1.0	2.36244
intracellular organelle part	LOCATE Curated Protein Localization Annotations	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11623_KD_DUSP11_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.5103
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02529
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
vegetative cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.234016
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
High vocal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
WTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59571
Pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
GABARAPL1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSII associated light-harvesting complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.972
colorectal	GeneRIF Biological Term Annotations	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242769
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6992-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
significant	GeneRIF Biological Term Annotations	1.0	null
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40061857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34819
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255069
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297771
Prostate adenocarcinoma_PRAD_TCGA-EJ-5507-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42721
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921663
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
FAM96B	Pathway Commons Protein-Protein Interactions	1.0	null
Leukoplakia	DisGeNET Gene-Disease Associations	1.0	null
tretinoin-1636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intestinal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118903
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.19777
Esophageal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77987907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2557
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CAVIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03777
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2755
PTK2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47284
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K57969360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25942
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
TF	Pathway Commons Protein-Protein Interactions	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8283
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20133
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.419
PCMT1	Pathway Commons Protein-Protein Interactions	1.0	null
induce	GeneRIF Biological Term Annotations	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.574126
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.732691
NCIH2029	CCLE Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6595-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL15	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44253
RISC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_4_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.906565
Sarcoma_SARC_TCGA-DX-A1KU-01A-32R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31047
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41392
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-RUNX3_mod_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77290793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54749
TBP	ENCODE Transcription Factor Targets	1.0	null
colon_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.825912
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41363
ZNF384_02_203	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.66856
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.866666
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51887
Pharyngeal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.242
nicergoline-5775	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMPD1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6814
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238145
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4933
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05607
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62128
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.976576
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961292
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894425
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.97256
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
norfloxacin-5985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4781-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17338
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360888
SETDB1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
VCaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
FLCN	Pathway Commons Protein-Protein Interactions	1.0	null
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084652
inducing	GeneRIF Biological Term Annotations	1.0	null
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02336
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.75567
FAM91A1	Pathway Commons Protein-Protein Interactions	1.0	null
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.191
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
hiv1mrnas	GeneRIF Biological Term Annotations	1.0	null
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
GSE130690,GSE130692_2_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cytosolic large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.026
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22964
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845898
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
MAP1LC3A	Pathway Commons Protein-Protein Interactions	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.943
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
groups	GeneRIF Biological Term Annotations	1.0	null
oxybutynin-3168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.659139
ATF3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87276
dacarbazine-4480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61462
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09324
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0577
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96991,GSE97117_5_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.28145
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.921837
hsa-miR-146b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19498
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75239
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
hsa-miR-320c	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
EE-08-SZ54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239241
POF1B	Pathway Commons Protein-Protein Interactions	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.154
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.863493
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2414
BGC823	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59514
clemizole-2301	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
activin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.668992
BRD-K27723822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79798
phenotypic	GeneRIF Biological Term Annotations	1.0	null
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2603
PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A20463452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28691
TM31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54967
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PLZ6-0526-SM-3P61C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987317
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4075
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-PCM-NR1H2_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25194
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15359_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.75729
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54935
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
epithelialmesenchymal	GeneRIF Biological Term Annotations	1.0	null
BRD-K92712671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42461
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19236
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
highly	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.625869
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226268
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445733
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.46476
independent	GeneRIF Biological Term Annotations	1.0	null
AGO2	Pathway Commons Protein-Protein Interactions	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
C18orf32	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19228
cefapirin-3471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.14345
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.836095
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.572
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07391
PTK7_KD_GSE50138_675_human_H2009	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	102.625
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880622
hsa-miR-4528	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
Indapamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRA2A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE190186,GSE190188_8_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44236
only	GeneRIF Biological Term Annotations	1.0	null
GSE151612_0_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5930_KD_MBD3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.89859
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-0926-SM-48FEP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852574
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BEND5	Pathway Commons Protein-Protein Interactions	1.0	null
Spinal nucleus of the trigeminal, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00272
Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
LMO2	ChEA Transcription Factor Targets	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21224
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09505
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76847
tenoxicam-4182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S341-0626-SM-4AD5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866392
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09108
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EPDR1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-54-ZNF615_ZNF615	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06763
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22545
7651_SAP30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657012
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54351101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.03759
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22534
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.486829
CALU1_LUNG	CCLE Cell Line Proteomics	1.0	3.94774
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4926
PMC12255818-41467_2025_61448_MOESM1_ESM.pdf-51-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35245
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.872931
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72226
urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.346409
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NXF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
metaphloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.183816
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21883
H3K9me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09096
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32752
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.483596
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
saquinavir-5770	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092855
CAL51	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39148
LRSAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79541
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27623
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.972
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.80936
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mebendazole-2300	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
male gamete generation	GO Biological Process Annotations 2015	1.0	null
ATF3_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4719	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8305
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
KRT82	Pathway Commons Protein-Protein Interactions	1.0	null
E2F1-21310950-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32779
hsa-miR-27b	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.98
Stoma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.043
PDCD6IP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11640_KD_ITCH_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.96866
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372497
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15504
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84435
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZCCHC8	Pathway Commons Protein-Protein Interactions	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.866874
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CP-319743-7491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38305
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28081
sulfachlorpyridazine-2191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.872931
hsa-miR-4668-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical Cancer	DisGeNET Gene-Disease Associations	1.0	null
PTPLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3285
339_ANKRD39_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57273
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7911
BRD-K58323923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26751
SIN3B	ChEA Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07013
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LA-31-YT57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208425
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76817
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61E-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.29051
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986658
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00485
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86834
KRT77	Pathway Commons Protein-Protein Interactions	1.0	null
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
angiogenesis	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931921
SAFB2	Pathway Commons Protein-Protein Interactions	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374358
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mebendazole-3671	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-548u	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7868
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48969
5155877-6544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
18056454-Table2	GeneSigDB Published Gene Signatures	1.0	null
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18768
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31802
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23542
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clomipramine-3182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04731
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3678-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Colorectal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.651
regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72081
hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.528449
MARCKS	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chlorpromazine-6176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78816149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61428
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Translation protein SH3-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
ARF1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2126	DepMap CRISPR Gene Dependency	1.0	5.31761
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Flemming body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.55
MYOG	ENCODE Transcription Factor Targets	1.0	null
GSE148066,GSE157787_2_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.523
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7379-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.24051
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.638282
Lung squamous cell carcinoma_LUSC_TCGA-L3-A524-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.440914
A388	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
LC4-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48893
PTK7_KD_GSE50138_674_human_H1299	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thylakoid light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.952
eif4d	GeneRIF Biological Term Annotations	1.0	null
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.703413
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30908
HSPA4L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42306
Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gallbladder Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32203
GATA1	ChEA Transcription Factor Targets	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88252
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4712-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.219
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8058
norethisterone-7414	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07728
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27991961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20905
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.827706
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.402901
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09593
GBAS	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881889
BRD-K64836560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07224
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60664
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.953
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886631
BRD-K71672234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60727
GBM-8401 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.121
BRD-K76729384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39605
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213367
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27663
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342851
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C-reactive protein levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3127
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38825
sw837	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
hsa-miR-491-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
HuH-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
extracellular region part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.063445
dihydroergocristine-7034	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853804
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retinitis pigmentosa 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A-2058 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
knowledge	GeneRIF Biological Term Annotations	1.0	null
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55842
BRD-K60701773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39946
primary motor cortex (area M1, area 4)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42789
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877501
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7741
HIST1H2AB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08711
SAMHD1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4775-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK4	JASPAR Predicted Transcription Factor Targets	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.197
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916758
hsa-miR-4766-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
(S)-Selisistat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
ETS1	ENCODE Transcription Factor Targets	1.0	null
PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202295
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
BRD-K50893227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30071
MERO25	DepMap CRISPR Gene Dependency	1.0	3.81314
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73378
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20868
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44071
Perturb_4595_KD_Trp53_SRP372551	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
DSG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15128331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53444
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
ChIP_SUZ12_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32532
6603-0104	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
DOK1	Pathway Commons Protein-Protein Interactions	1.0	null
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32674
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.863666
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84145
BRD-K84178323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21845
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08727
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZINC6198410	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.4392
TBC1D2B	Pathway Commons Protein-Protein Interactions	1.0	null
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
stat3	GeneRIF Biological Term Annotations	1.0	null
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.831568
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23725
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89402302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20055
GSE85302_0_v_1_kat6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decitabine-920	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237831
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pollen tube tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60937
DDX20	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96705
proxyphylline-5993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38627
SRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34889
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10406
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pharyngeal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11156
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09932
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.86778
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6421
SRRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85347
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex binding	GO Molecular Function Annotations 2015	1.0	null
Stage Iib Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.96462
hecogenin-2716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07152092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10699
BRD-K34028745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0925
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
tgfbeta1	GeneRIF Biological Term Annotations	1.0	null
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
Rabies CVS-11_7day-Spinalcord_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58225
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Oropharyngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.551
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90673
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94457
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4327	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.2984
hydroquinine-5789	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-R-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-3114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SA-A6C2-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BMI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15887
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31976
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26906
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.54715
phenylpropanolamine-5298	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18974
hsa-miR-4659b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5004-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Buspirone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
S117	CCLE Cell Line Gene Expression Profiles	1.0	1.7339
OAT	Pathway Commons Protein-Protein Interactions	1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.545
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-125b	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_18014_KO_miR19a/miR19b1_SRP050491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.85995
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08954
FTSJ3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06184
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13538
positive regulation of translation	GO Biological Process Annotations 2015	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	1.25785
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-518d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
CTNNBIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01801
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRSF9	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
squamous	GeneRIF Biological Term Annotations	1.0	null
Perturb_5789_KO_Tnfrsf11a_SRP103818	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.94666
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A92357389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34964
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14035
JUN	ENCODE Transcription Factor Targets	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-MEL-28	GDSC Cell Line Gene Expression Profiles	1.0	2.19645
regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900065
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.9963
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-2.06309
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
albendazole-7164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A21524347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10034
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.06068
hsa-miR-3136-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949152
equilin-3039	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.911123
glioblastoma	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
peptidyl-lysine modification to peptidyl-hypusine	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16209
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20324
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_18607_Mut_Chek1_SRP299085	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.49106
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06173
PPA1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4526	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
NFKBIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57394
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0107
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
naftidrofuryl-5287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48681
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02297
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21332
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
melatonin-2431	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-0926-SM-48TD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871212
Nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
EPPK1	Pathway Commons Protein-Protein Interactions	1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ondansetron-5796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64692525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05418
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850943
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.894597
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
laminin-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.856
simvastatin-4828	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NEK1	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.837949
Perturb_16312_KD_SF3B4_SRP349464	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
DHPS	Pathway Commons Protein-Protein Interactions	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.43146
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PRDX2	Pathway Commons Protein-Protein Interactions	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.8197
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenylpropanolamine-3217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sirolimus-1646	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
marker	GeneRIF Biological Term Annotations	1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12334
eukaryotic	GeneRIF Biological Term Annotations	1.0	null
CB-24-FA25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238376
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965469
binds	GeneRIF Biological Term Annotations	1.0	null
GTEX-VUSG-1226-SM-4KKZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16549
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-203	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_chimp_DRSG_higherRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98477
PSMC3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207855
18959789-Table4	GeneSigDB Published Gene Signatures	1.0	null
POFUT2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04929
CYP4Z2P	Pathway Commons Protein-Protein Interactions	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37281
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4859
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09241
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213471
tremorine-6273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
saquinavir-6246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MRPS22	Pathway Commons Protein-Protein Interactions	1.0	null
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-STAT4_mod_STAT4	Rummagene Transcription Factor Associations 2026	1.0	null
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243677
hsa-miR-4501	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
CRCGN014_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14259
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947247
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16888026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95982
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UMUC11	DepMap CRISPR Gene Dependency	1.0	2.93684
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCC2	Pathway Commons Protein-Protein Interactions	1.0	null
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15072
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.838444
Sapropterin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
Perturb_9240_KD|OD_ENL|ENL_SRP074134	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.38471
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.0088
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.029271
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70479
H-1299	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06809
hsa-miR-4678	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.30484
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8815
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12857
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19413
KYSE70_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.45735
rosiglitazone_mus musculus_gpl7202_gse19896	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IOSE-29 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.037
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35332
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEP-3B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.416
CREB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897122
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959684
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59201
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88492
streptozocin-7193	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PITX1-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.96
hsa-miR-146a	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
CE-18-CG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241594
Perturb_9132_KD_Epas1_SRP049514	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.60141
PSMB1	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18393
Male inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20X-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT6A	Pathway Commons Protein-Protein Interactions	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Carcinoma Of Urinary Bladder, Invasive	DisGeNET Gene-Disease Associations	1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983787
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59943
Root pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88822
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
SW-480 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.357
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF7_01_340	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60785
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1432
patient	GeneRIF Biological Term Annotations	1.0	null
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25047
ALDOA	Pathway Commons Protein-Protein Interactions	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.337808
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE134191_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3985
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958212
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.914
r5 part of the oral Sp5 subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09842
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77006
A-704 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
BRD-K77108448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11597
azacitidine-4010	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8191
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27138
Secondary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
Plant cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
m4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
seneciphylline-2797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nidopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
PRKAR2A	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
resveratrol-5509	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.882555
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP1S	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899377
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.916323
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12109
SNB75	DepMap CRISPR Gene Dependency	1.0	2.92581
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.32999
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07681
mesenchyme	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.613361
pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068886
BRD-K37480258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00458
colistin-2491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ribonuclease III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
H3255	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07441
GADD45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23761
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49065
pimozide-3178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervix Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4764-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ABHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17397
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K97886487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52059
hsa-miR-4272	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
enzymes	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Perturb_14497_KD_BCLIN25_SRP326142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03617
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1841
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
asiaticoside-3504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF384	Pathway Commons Protein-Protein Interactions	1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67325
Perturb_11644_KD_KCNQ4_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.81695
PSMB5	Pathway Commons Protein-Protein Interactions	1.0	null
NZOV9	DepMap CRISPR Gene Dependency	1.0	3.54943
anterior digastric muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07129
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HCC1359	CCLE Cell Line Gene Expression Profiles	1.0	1.7452
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tongue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152399
MYL12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07719
Perturb_446_KD_FOXP1_SRP127520	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319244
EXOSC9	Pathway Commons Protein-Protein Interactions	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09863
LY-294002-6987	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_1727_KO_Mdmx_SRP301763	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.47161
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12288
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20743
hsa-miR-3929	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12155
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.361
CHO-MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
BRD-K42776812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55523
TCF3-18467660-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CDC5L	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
NPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51951
BRD-K93800933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0966
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830844
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Elaioplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
SUIT-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01413
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19555
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.07572
RASSF5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42455150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25014
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1399
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.878028
FLI1	ChEA Transcription Factor Targets	1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NSMAF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90464
nasopharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124211
OCIM2	DepMap CRISPR Gene Dependency	1.0	2.6415
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.926788
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.882
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_14496_KD_BCLIN25_SRP326142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SNRPC	Pathway Commons Protein-Protein Interactions	1.0	null
EXOSC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25352
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
betulinic acid-3281	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43472
BRD-K76426411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26661
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15713
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
triamterene-1697	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Microgametophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31275250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02592
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43571
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.46621
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.625
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CYP2C8	Pathway Commons Protein-Protein Interactions	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12737
Pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
Gastric adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096171
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Tumor Angiogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
propoxycaine-3583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.531
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.896894
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06936
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876477
SIRNA_EIF4GI	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994417
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J7-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4652-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15021
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98915
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.895
Fingolimod	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83435
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85615
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8164
(+)-chelidonine-2779	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839934
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.898756
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
samples	GeneRIF Biological Term Annotations	1.0	null
TTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10331
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHTOP	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07839
COV-644	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
carbamazepine-952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.811
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-7	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Plastid ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.057
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063968
ZFX_01_157	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.81531
6629_PPIL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524994
BRD-K36340167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22259
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22327
there	GeneRIF Biological Term Annotations	1.0	null
HNF4A-19761587-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251272
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65406
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-STAT4_mod_STAT4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13412_KD_Ppp3cc_SRP193770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.7695
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.14567
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.78423
GSE139975_3_v_1_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ribosomal protein L2 domain 2	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SP1	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909768
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55576
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.873418
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1028
TBCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77542
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Aprepitant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
PMC6293073-LSA-2018-00153_TableS3.xlsx-C_KD_Tr_4_genes-66_genes_upregulated_upon_knockdown_of_Tr_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GMDS	Pathway Commons Protein-Protein Interactions	1.0	null
LETM2	Pathway Commons Protein-Protein Interactions	1.0	null
transport	GeneRIF Biological Term Annotations	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04056
VD-14-CD80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239148
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCB000038-7547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALEXANDERCELLS	CCLE Cell Line Gene Expression Profiles	1.0	2.0233
benserazide-5322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	2.1595
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7854
hsa-miR-3666	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
dhs	GeneRIF Biological Term Annotations	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL36A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83282
cefaclor-2843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
TIA1	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523554
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
ESR2_01_229	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.3
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29118
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386988
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
HSD17B4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06519
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-628-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39713
hypusineforming	GeneRIF Biological Term Annotations	1.0	null
tetrahydroalstonine-6209	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GLC82	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41078
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.82413
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE192771_2_v_1_mt1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01317
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FaDu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
AC-97-KP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256402
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN_KO_GDS4205_294_mouse_B lymphoid cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
methylergometrine-5303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.70604
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PFSK-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60388
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANXA1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.12357
Perturb_5821_KD_Pcbp1_SRP324137	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45016
Oral squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
hsa-miR-130b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12669
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28969
periventricular stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01634
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06284
Ovarian Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-dORF6_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.76263
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82928
APOBEC3B	Pathway Commons Protein-Protein Interactions	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45114
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06891
DOHH	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66558
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33744
GABARAP	Pathway Commons Protein-Protein Interactions	1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.923
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.398
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.91
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
propoxycaine-6803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932886
Stage Iii Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
anterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01548
asiaticoside-7004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ovary cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070963
OV90	CCLE Cell Line Gene Expression Profiles	1.0	1.96532
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.64436
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59524
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
folic acid-7201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.47366
BRD-K96652989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40767
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
NCIH2052	CCLE Cell Line Gene Expression Profiles	1.0	2.18753
HNF4A-19761587-HUMAN INTESTINAL CELL LINE CACO-2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BACH1_01_59	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.86686
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91923
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.019
Cytosolic small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.204
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.378514
Translation elongation factor IF5A	InterPro Predicted Protein Domain Annotations	1.0	null
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
Hypusine synthesis from eIF5A-lysine	Reactome Pathways 2014	1.0	null
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22061
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29765
stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.203275
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868557
PMC3435504-msb201237-s2.xls-Supp_Table_4b-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.8066
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
Uridine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-1626-SM-3P618	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02607
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43343
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10607
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15647573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17656
Anthranilate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.568
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55973
BRD-K30298864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57099
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08507
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.857029
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30605
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Compound leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5204
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE-270	GDSC Cell Line Gene Expression Profiles	1.0	2.92502
hsa-miR-4253	TargetScan Predicted Conserved microRNA Targets	1.0	0.029271
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03864
scriptaid-6896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5562
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
translation elongation factor activity	GO Molecular Function Annotations 2023	1.0	null
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.447192
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
no abnormal phenotype detected	MGI Mouse Phenotype Associations 2023	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PLOD3	Pathway Commons Protein-Protein Interactions	1.0	null
LTBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08911
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212791
SW-1736 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.156
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HSPA7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01554997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52956
higher	GeneRIF Biological Term Annotations	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.319863
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07009788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20019
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048033
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0696
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0358
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SEC61A1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.836095
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20068109-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
positive regulation of protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
nordihydroguaiaretic acid-6983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Infratentorial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959037
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
smallintestine_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.59138
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.15739
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.90448
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974445
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59956
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22352
Ovarian cystadenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SDHB	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF526	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88796
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00845
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2969
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55362
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.519961
PMC2694838-1471-2164-10-241-S3.xls-Sheet1-Commonly_altered_genes_by_ZNF191_overexpression_and_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDC25C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27982
BB65-RCC	GDSC Cell Line Gene Expression Profiles	1.0	2.10508
CTSD	Pathway Commons Protein-Protein Interactions	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.884432
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reproductive process	GO Biological Process Annotations 2015	1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	2.70934
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.52521
BRD-K80239721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8378
COG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16669
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
albendazole-3164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.65884
phenindione-7289	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09631
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337432
GSE96641_3_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
7275_RGS14_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.782978
mefenamic acid-1821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36613
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66392
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tretinoin-3165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
HIST2H2BE	Pathway Commons Protein-Protein Interactions	1.0	null
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.95299
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.54988
BRD-K84054400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13976
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
shortened	GeneRIF Biological Term Annotations	1.0	null
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17171
hsa-miR-130b	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0989
FSCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40048
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17171256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16413
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26083
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VU-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4261	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
RPL10L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WM3772F	DepMap CRISPR Gene Dependency	1.0	3.39359
Prestwick-967-4833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52817
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17532_KD_C1QBP_SRP270881	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
minor	GeneRIF Biological Term Annotations	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239307
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.51162
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
S-117	GDSC Cell Line Gene Expression Profiles	1.0	1.78671
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48372955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00736
BRD-A22502289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03012
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26349
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89954
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912197
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.966075
Pancreatic Ductal Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE249146_2_v_3_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8824_KD_DDX60L_SRP313537	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51534
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88146
TCF3-18467660-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
well	GeneRIF Biological Term Annotations	1.0	null
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17192
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.024
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02509
MYC	ENCODE Transcription Factor Targets	1.0	null
chemical homeostasis	GO Biological Process Annotations 2015	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
similar	GeneRIF Biological Term Annotations	1.0	null
EIF5A	Pathway Commons Protein-Protein Interactions	1.0	null
butacaine-6225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CAT	Pathway Commons Protein-Protein Interactions	1.0	null
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_2-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
cefoxitin-3477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02706
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05759
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsalrootganglion	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09811
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04253
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Polysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.274
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-6843-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.77744
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32843
YWHAG	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89339
Ovary cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH2170	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53474
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70901
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.37278
papaverine-6245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00833
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KRT4	Pathway Commons Protein-Protein Interactions	1.0	null
GATA1-19941827-MEL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_17244_KO_Klf3_SRP029447	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.51149
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
COR-L23	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47716
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550105
T-24 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.028
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984248
hsa-miR-335	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
hsa-miR-548aa	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.3794
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31988
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reproduction	GAD High Level Gene-Disease Associations	1.0	0.293278
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79148
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.892969
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR3A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FHC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938537
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4726-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ALDOC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.191
Perturb_6654_KO_Kdm4a/Kdm4b/Kdm4c_SRP190031	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.58086
FU97	CCLE Cell Line Gene Expression Profiles	1.0	1.47841
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08065
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22016
DMS-53	GDSC Cell Line Gene Expression Profiles	-1.0	-2.58982
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.73589
BRD-K56427898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6202
CJM	CCLE Cell Line Gene Expression Profiles	1.0	1.55205
NCIH1437_LUNG	CCLE Cell Line Proteomics	1.0	2.36244
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPOTS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.925
hsa-miR-765	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249977
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_374_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08561
hsa-miR-2278	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTN1	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A68323834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47852
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
hsa-miR-153	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
hexestrol-6252	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.916
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88737
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.983
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07035
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34699
Ivabradine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
Sinomenine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.016855
hsa-miR-520a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5022
cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ANXA4	Pathway Commons Protein-Protein Interactions	1.0	null
phenotype	GeneRIF Biological Term Annotations	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77109
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	1.77481
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1-19941827-MEL-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21272
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.48517
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.99657
OPTN	Pathway Commons Protein-Protein Interactions	1.0	null
RPS17	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-1322	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80273
BRD-K13211285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27143
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4514	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.511496
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858097
DSC2	Pathway Commons Protein-Protein Interactions	1.0	null
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7272
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0043
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gf95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
19808871-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hep-3b cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34963
EP300	ENCODE Transcription Factor Targets	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920698
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148514_0_v_1_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cefalotin-6819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.0175
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88996011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32636
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01109
medial amygdala, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25332
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38873
homatropine-1806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85586
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40085
CTPS1	Pathway Commons Protein-Protein Interactions	1.0	null
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16776
staining	GeneRIF Biological Term Annotations	1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31676
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
hypusine	GeneRIF Biological Term Annotations	1.0	null
SERPINB3	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.3914
coralyne-6317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967882
liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.525746
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34873
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H1C	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.061
monorden-953	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEX10	Pathway Commons Protein-Protein Interactions	1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.46685
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.975802
rac1	GeneRIF Biological Term Annotations	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-1178	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LGALS7B	Pathway Commons Protein-Protein Interactions	1.0	null
RNF2	ChEA Transcription Factor Targets	1.0	null
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.961424
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.42851
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970436
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09444
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227181
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.917961
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_20_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4495	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
PMC4122406-pone.0104158.s012.pdf-6-HOXA13_HOXA13	Rummagene Transcription Factor Associations 2026	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01629
peptidyltransferase	GeneRIF Biological Term Annotations	1.0	null
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.488
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT-112	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61188
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76908
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.996829
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90444258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54661
SETDB1	ENCODE Transcription Factor Targets	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06173
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1CB	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61964
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897626
u251mg	HPA Cell Line Gene Expression Profiles	1.0	1.18276
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.980477
KDM5A	ENCODE Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.864065
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.98475
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sulfamethoxazole-2296	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BICR22	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24059
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7196
BRD-K61223323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30531
Mesothelioma_MESO_TCGA-TS-A7OY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06284
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
SF295	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00345
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25551
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.869212
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837416
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
polyamine homeostasis	GO Biological Process Annotations 2015	1.0	null
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54276
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4197
MFE280	CCLE Cell Line Gene CNV Profiles	1.0	1.9655
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.015
BRD-K47584662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55666
PMC5577301-in-17-237-s001.xls-AR_upregulated_DEGs-Liver_GSE13440_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.545093
RCOR1	ENCODE Transcription Factor Targets	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0926-SM-4AD4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0342
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
PPARD	ChEA Transcription Factor Targets	1.0	null
TECR	Pathway Commons Protein-Protein Interactions	1.0	null
flufenamic acid-5478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09349
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XBED-0726-SM-4GIAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08096
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02405
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34671
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292645
CALML5	Pathway Commons Protein-Protein Interactions	1.0	null
tridihexethyl-3526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.8517
blood vessel	GTEx Tissue Gene Expression Profiles	1.0	0.959923
HDAC2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16079077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8301
BRD-K71486304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85259
Urinary bladder carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.06
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840222
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943947
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11716045-peerj-13-18816-s007.xlsx-Sheet1-ZNF440_ZNF440	Rummagene Transcription Factor Associations 2026	1.0	null
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.15574
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_12Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.97309
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20685
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26009
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11545
ovary cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48535
RDX	Pathway Commons Protein-Protein Interactions	1.0	null
HSP90B1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71893034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06547
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B-CPAP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.855
Oral cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSNK2A1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163361
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11368
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.945
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
benzonatate-1801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K86884344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26694
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30004
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25298
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0294
TTF2	ChEA Transcription Factor Targets	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85977749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22146
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44272
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4706
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
BRD-K15290974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69675
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RH00511	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
ovary	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41305
LY-294002-1239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67832115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2329
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
icSARS-Cov_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.16412
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87579
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53308
BRD-K09117810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16914
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Leupeptin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87961
strophanthidin-7182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K96440230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48872
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35872
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.846605
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19549
Hypusine	HMDB Metabolites of Enzymes	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.679074
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PML_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914365
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Nanotubes, Carbon	CTD Gene-Chemical Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35956
SPI1	ChEA Transcription Factor Targets	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.600348
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07312
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00856
hsa-miR-3935	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Adult Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71994
GSE133516_0_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESS-1	GDSC Cell Line Gene Expression Profiles	1.0	1.47545
STL304557	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03368
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38538
CANX	Pathway Commons Protein-Protein Interactions	1.0	null
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
IPC298	CCLE Cell Line Gene CNV Profiles	-1.0	-2.30379
8645_TACC3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613879
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.882525
cinoxacin-3463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.768814
GABARAPL2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.829881
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30501
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04404
LC1SQSF	CCLE Cell Line Gene Expression Profiles	1.0	2.23493
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.539656
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A40504327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35943
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64975
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.178
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4847
WDR45B	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8593
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6678_KO_PMVK_SRP255872	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.8326
H3K9me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
786-O	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36745
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901886
bupropion-6256	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40468
ENO2	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.8885
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
SET	Pathway Commons Protein-Protein Interactions	1.0	null
YAE1D1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A655-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0948
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6707
RAD51AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79956
intermediate stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18495
GART	Pathway Commons Protein-Protein Interactions	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04218
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217776,GSE217829_2_v_0_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48596
16912175-SuppTable3a	GeneSigDB Published Gene Signatures	1.0	null
TEAD4-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78813464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90269
primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.845622
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.898218
GBC-SD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288661
HSPA4	Pathway Commons Protein-Protein Interactions	1.0	null
Triple Negative Breast Neoplasms	DisGeNET Gene-Disease Associations	1.0	null
THOC6	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCK81_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.81168
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-520c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
selegiline-2465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72801
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14782
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.906721
dirithromycin-2863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45073068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00266
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864579
bromovanin	CTD Gene-Chemical Interactions	1.0	null
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23839
KMRC1	CCLE Cell Line Gene Expression Profiles	1.0	1.58504
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965111
C1orf131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30722
RAB39A	Pathway Commons Protein-Protein Interactions	1.0	null
promotes	GeneRIF Biological Term Annotations	1.0	null
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46825
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612555
Translation repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.58352
CHD2	ENCODE Transcription Factor Targets	1.0	null
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.795336
Childhood Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-1326-SM-4AT63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924401
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.1267
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9796
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47169
CYP20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33233
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.65911
CRCGN009_HEPG2_24H:C16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1993
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89983
GSE154577_6_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CF-97-AV07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267053
clofazimine-5642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP1LC3A	Hub Proteins Protein-Protein Interactions	1.0	null
Translation elongation factor, IF5A C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08156
TBCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59519
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GSE126345_11_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
10442_ZNF554_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513862
Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
16288205-GeneTable3	GeneSigDB Published Gene Signatures	1.0	null
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.899443
H3K9me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.839326
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.8834
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18313
Thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.897297
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.627479
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869014
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-WK-A8XS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trimethoprim-4701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.143457
RNPS1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13122526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75437
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3993
hsa-miR-3614-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
CP-319743-7537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.599007
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12138
Dexrazoxane	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07438
NCIH661_LUNG	CCLE Cell Line Proteomics	1.0	5.64061
BRD-K44908610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74161
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17033
NCIH226	CCLE Cell Line Gene CNV Profiles	-1.0	-2.70528
malignant	GeneRIF Biological Term Annotations	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36875
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04470135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19721
BRD-K48827674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1005
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
CORO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06832
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35648
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05625
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980705
hsa-miR-586	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
PMC6089552-oncotarget-09-31018-s004.xlsx-compound_targets_chip_rnaseq-Chip-seq_derived_EWS-FLI1_targets_Bilke_et_al_2013_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12076
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958418
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFEB-21752829-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
shikonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07107
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07298
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.62966
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865312
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07882
5252917-944	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
invasion	GeneRIF Biological Term Annotations	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8495
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.886613
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29858
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64564
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.438
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.8696
RCC2	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A64Z-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rilmenidine-3133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCBTB1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.90301
BRD-K72156149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12736
H1FX	Pathway Commons Protein-Protein Interactions	1.0	null
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
EFO-21	GDSC Cell Line Gene Expression Profiles	1.0	1.55048
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946489
PMC7062471-elife-52504-supp6.xlsx-TEAD4_motif_in_OCR_around_DEGs-Gene_ID_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975003
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z1-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39648
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21002
theophylline-4812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	2.85832
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29929
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30472
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCB000040-7493	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Medulloblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE172494_2_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STK11_knockout_278_GSE34866	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.74683
377_AP2M1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591188
hydrastinine-2119	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ACD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12779
TRIM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03621
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Linagliptin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
r4 part of pontine raphe cell population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02826
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38912
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12414
hsa-miR-4701-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
BRD-K75989234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10166
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
METTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01901
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12841
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
differences	GeneRIF Biological Term Annotations	1.0	null
SCN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87244
U2OS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53244
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gallbladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
hsa-miR-889	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223812
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1295
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2241
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851703
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10385
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53651
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PCBP3	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
bladder	GeneRIF Biological Term Annotations	1.0	null
SUZ12	ChEA Transcription Factor Targets	1.0	null
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCCSUP	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46167
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
efo21	HPA Cell Line Gene Expression Profiles	1.0	1.12651
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66045
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.1922
VTN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37515
Lung squamous cell carcinoma_LUSC_TCGA-18-3417-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55697
RPL37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31268
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23213
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9969
PIK3CA	Pathway Commons Protein-Protein Interactions	1.0	null
prochlorperazine-1640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6277
Squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Bladder Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
MTHFD1L	Pathway Commons Protein-Protein Interactions	1.0	null
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02776
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95352
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3309
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15829
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6961-01A-21R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11868582-41423_2025_1264_MOESM4_ESM.xlsx-Table_S15-Table_S15_List_of_the_genes_commonly_regulated_by_AhR_and_OVOL1_in_TSB-treated_NHEKs_OVOL1	Rummagene Transcription Factor Associations 2026	1.0	null
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85996308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33206
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979288
rhoa	GeneRIF Biological Term Annotations	1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834714
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881889
cefalexin-2628	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSP90AA2	Pathway Commons Protein-Protein Interactions	1.0	null
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.44455
TUBB1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_9005_KD_GATA6_SRP014027	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.62444
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43691
hsa-miR-17	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.60117
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
upregulating	GeneRIF Biological Term Annotations	1.0	null
inhibited	GeneRIF Biological Term Annotations	1.0	null
SUZ12-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4531
YWHAH	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-578	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961297
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32008
BRD-K40887375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13137
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880479
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10761381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11929
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21824
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26757
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.2099
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37901
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_228_KO_Lmx1b_SRP194283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.71291
esophagus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.134485
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K38557431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05489
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282331
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44404
Carcinoma, Transitional Cell	DisGeNET Gene-Disease Associations	1.0	null
CRCGN015_HEPG2_48H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6505
BRD-K86545229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47683
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Esophageal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.633
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218737
ERI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39134
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60536
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27444
BRD-K95537020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1707
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
valproic acid-5206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3573
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8145
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3476
PPP1CC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41532285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06277
PF-00875133-00-5928	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35037
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AAMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84187
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
increases	GeneRIF Biological Term Annotations	1.0	null
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7423-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9338313-41467_2022_32034_MOESM4_ESM.xlsx-Control_HS_0-Table_S1_HSF1-interacting_proteins_enriched_upon_heat_shock_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2503
S100A8	Pathway Commons Protein-Protein Interactions	1.0	null
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11585
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47578
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-8500-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972318
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47765
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30676
BRD-A61014366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07535
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DHX8	Pathway Commons Protein-Protein Interactions	1.0	null
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269296
hsa-miR-374c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303559
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13852
JHH6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6913
Urinary bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.06
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0911
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98433
gastric cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.271952
BRD-K57938735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31891
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38912
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4477b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05132
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Gastric cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.222
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
KRT3	Pathway Commons Protein-Protein Interactions	1.0	null
Tubastatin A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93594
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
translation factor activity, nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
NCIH747_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.48612
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.268
BRD-K01286616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29224
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-FERNANDEZ_BOUND_BY_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8851354-Table_2.xlsx-Genes_reg_by_FUS-DDIT3-Supplementary_Table_2_Genes_significantly_regulated_by_FUS-DDIT3_expression_in_HT1080_cells_adjusted_p-value_0_05_and_log2_Fold_change_1_or_-1_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11075
20081105-Table4	GeneSigDB Published Gene Signatures	1.0	null
PLOD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.751339
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5255
F7	Pathway Commons Protein-Protein Interactions	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851963
acetylsalicylic acid-5201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC25A32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46489
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.871446
cefuroxime-5787	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-519b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.88801
HUG1N	CCLE Cell Line Gene Expression Profiles	1.0	2.52338
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05526
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
Cardiomyopathy_Myocardial tissue_GSE1869	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.10379
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02528
primary auditory cortex (core)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34752
NIF3L1	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23499378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14959
U20S	BioGPS Cell Line Gene Expression Profiles	1.0	0.830554
hsa-miR-340	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	2.00384
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27895
BRD-K30625175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23184
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13257
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cotinine-1511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K02934881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68884
Bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.738
PFDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29991
RBM12B	Pathway Commons Protein-Protein Interactions	1.0	null
TRAFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04043
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A4AC-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SALL4-18804426_ESC-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850815
5928_OGFOD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556588
oxytetracycline-3170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
josamycin-1534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.051472
Lung squamous cell carcinoma_LUSC_TCGA-77-7338-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.615138
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PRMT5	Pathway Commons Protein-Protein Interactions	1.0	null
LoVo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC31A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25749
mepacrine-3179	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548o	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE140284_0_v_1_hhex_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34035
PANC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.195
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06515
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38045
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13408
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
gastric adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.512957
infertility	GeneRIF Biological Term Annotations	1.0	null
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30667
vinpocetine-3174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUDT1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4429	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CLINT1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.759914
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02392
esophageal	GeneRIF Biological Term Annotations	1.0	null
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54763
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-224	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9171
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QPCT	Pathway Commons Protein-Protein Interactions	1.0	null
oc316	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
mantle zone of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23185
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840393
Adrenocortical carcinoma_ACC_TCGA-OR-A5JQ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of translational elongation	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EC-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithelialmesenchymaltransition	GeneRIF Biological Term Annotations	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081207
Epithelial to mesenchymal transition in colorectal cancer	WikiPathways Pathways 2024	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46377
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	4.36937
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50435683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00879
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24004
Hypopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
regulation of protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31787
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66669
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A632-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P31-FUJ	GDSC Cell Line Gene Expression Profiles	-1.0	-2.01604
PLAUR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50701
Piccolo NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
IOSE80	BioGPS Cell Line Gene Expression Profiles	1.0	0.980223
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TTA-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529582
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFA4	Pathway Commons Protein-Protein Interactions	1.0	null
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18941
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61696
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
survival	GeneRIF Biological Term Annotations	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mecamylamine-7263	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.884916
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-0626-SM-4BRV5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826841
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06781
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.72257
ebselen-2717	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92185
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02766
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
AGL	Pathway Commons Protein-Protein Interactions	1.0	null
AGO3	Pathway Commons Protein-Protein Interactions	1.0	null
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.454
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33951
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
Ovary cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.637
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.857392
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5361-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K59093791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19383
BRD-K73899967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19583
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
major	GeneRIF Biological Term Annotations	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29748
Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06639
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5599
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43984
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3405
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54954
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC39A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42361
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16891
RANBP6	Pathway Commons Protein-Protein Interactions	1.0	null
Sporophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K28932578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64679
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01795
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.17151
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01296372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07413
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.343
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03825
BRD-K56354139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36223
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN_01_291	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.03898
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27199
hsa-miR-222	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Asarone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
17683518-813GeneTable	GeneSigDB Published Gene Signatures	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33103
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.857
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01012
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57795
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.882572
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HGC-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.11
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31327
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053404
translational elongation	GO Biological Process Annotations 2023	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84B-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10817
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15613
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_SOX17_20123909	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
EIF5AL1	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2457
BRD-K61943321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01438
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23031
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.628557
BRD-K00381858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19322
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIK3R2	Pathway Commons Protein-Protein Interactions	1.0	null
KEAP1	Pathway Commons Protein-Protein Interactions	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SALL4	ChEA Transcription Factor Targets	1.0	null
Adult Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930185
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88806312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75643
Photosystem II oxygen evolving complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
PDIA3	Pathway Commons Protein-Protein Interactions	1.0	null
PRKCI	Pathway Commons Protein-Protein Interactions	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ERH	Pathway Commons Protein-Protein Interactions	1.0	null
TBX5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959478
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99482
SAFB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892555
HUNS1	DepMap CRISPR Gene Dependency	1.0	2.2838
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular non-membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
translational elongation	GO Biological Process Annotations 2025	1.0	null
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
treated	GeneRIF Biological Term Annotations	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05922
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.971455
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02221
Esophageal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dinoprostone-6547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94277689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33524
Medulloblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.312
TBX5	ChEA Transcription Factor Targets	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.999
Urate levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.839794
NFYB	ENCODE Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LJ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H1_BMP4_Derived_Trophoblast_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.31052
deoxyhypusine	GeneRIF Biological Term Annotations	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.945
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.51011
SFN	Pathway Commons Protein-Protein Interactions	1.0	null
HSFX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95359
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF217_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586504
PMC3574814__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K60437668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64108
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.6932
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12824706-BLOOD_BLD-2025-028441-mmc3.xlsx-Fig4B_genes_inc_expr_NRF1-gene_name_NRF1	Rummagene Transcription Factor Associations 2026	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40801
KOSC2	DepMap CRISPR Gene Dependency	1.0	3.23959
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BxPC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-2.66168
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
procambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143449
SETDB1	ChEA Transcription Factor Targets	1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529724
Ebolavirus(EBOV)_6day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.5732
FNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPL-3026-SM-3MJGS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974458
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1768
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.76737
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
Hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.935
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
HO-8910 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261643
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041957
NCOA7	Pathway Commons Protein-Protein Interactions	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.71295
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8334-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93561
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310336
BRD-K67399222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24979
Ovary adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.235
cefalotin-4482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AA-79-SX47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288861
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01495
USF2	ENCODE Transcription Factor Targets	1.0	null
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribostamycin-2705	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LTV1	Pathway Commons Protein-Protein Interactions	1.0	null
suramin sodium-7529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
8458_SSRP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45835
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKN1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42331
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.970241
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908632
a-549 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.546929
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918495
hsa-miR-30a	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
NR2F2_01_90	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61553
rpmi8226	HPA Cell Line Gene Expression Profiles	-1.0	-1.68688
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058209
RARB-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7890-01A-12R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3568013-1471-2105-13-128-S4.xls-NME2-HGNC_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K21284411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01248
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
BRD-K63401195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28098
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.914819
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87338
pituitary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.901928
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880305
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054526
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.976241
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
cystectomy	GeneRIF Biological Term Annotations	1.0	null
BRD-K58077750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3495
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88143
PF-04418948	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12712
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50710722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29068
hsa-miR-1827	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.4341
Perturb_18610_KO_Btnl2_SRP324170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.73688
ZNF326	Pathway Commons Protein-Protein Interactions	1.0	null
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44594
CCNT2	ENCODE Transcription Factor Targets	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hydrastine hydrochloride-7309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03074
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30935
Pulvinus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
hsa-miR-3660	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.099471
BRD-K42123500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31377
hsa-miR-4711-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Indomethacin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938538
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0501
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
r6 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07972
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997784
Translation preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.733
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Childhood Medulloblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D542MG	DepMap CRISPR Gene Dependency	1.0	2.10407
BRD-K10031593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10144
RBM15B	Pathway Commons Protein-Protein Interactions	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.947767
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97493608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58637
MRPS11	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19767
MAFF	ENCODE Transcription Factor Targets	1.0	null
BRD-K58888361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24185
PTBP2	Pathway Commons Protein-Protein Interactions	1.0	null
PGAM4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81272
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.991488
SPI1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
medial portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88092
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215839
CIRBP	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
SR	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48508
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10035
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45018
BRD-K75252192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01089
Hypopharyngeal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
Perturb_1788_KO_Irf8_SRP265303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317722
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18443
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900946
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38147
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12558_OE_Aire_SRP033579	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE151494_10_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
GSE152441,GSE152442_1_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LC-1-SQ	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
acquired	GeneRIF Biological Term Annotations	1.0	null
Cystadenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19968
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.983156
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39461
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21192
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RB1_KD_GSE50532_593_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07501326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86687
3634_HAUS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.881849
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.879
DCC	Pathway Commons Protein-Protein Interactions	1.0	null
lamellipodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.227752
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3204
PMC10534007-Table_2.xlsx-S1_overlap_MSC_up_B_V-438_common_elements_in_BFTC905_MSC_up_and_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
ovary cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.544946
BRD-K55510118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12099
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.665
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66503
elk1_23426362_lncap_lof_human_gpl570_gse34589	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.590521
CRKL	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-106a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
eif5ai	GeneRIF Biological Term Annotations	1.0	null
HER2_KO_GDS4056_567_human_breast biopsies	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
conessine-4777	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Melanocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
medial habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26087
Perturb_12199_KD_XPC_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.0765
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.967474
synthase	GeneRIF Biological Term Annotations	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15691
Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADAR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE205332_2_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74091626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11337
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
Thyroid follicular epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
represent	GeneRIF Biological Term Annotations	1.0	null
BRD-K36798110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63947
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-125a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
RPTN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949349
positive regulation of translational elongation	GO Biological Process Annotations 2015	1.0	null
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus-1022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.892873
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K92365616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06064
15466190-Table1	GeneSigDB Published Gene Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-543	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054723
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220314
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863516
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
EIF2B1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07734
vorinostat-1220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MPP6	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17656
r3 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10878
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.025
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51335814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12031
pempidine-2172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUPT16H	Pathway Commons Protein-Protein Interactions	1.0	null
9400_TTK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.783088
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04145
CRCGN015_MCF10A.TP53.M_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45295
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56405
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.8967
SRSF4	Pathway Commons Protein-Protein Interactions	1.0	null
CDK4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7219_KD_RNF2_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28224
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
pontine nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19967
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-1269	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20533
NCI-H1304	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95062
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32989
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39716
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.31941
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11769652-EHF2-12-250-s001.xlsx-Sheet1-ZEB1_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
vorinostat-4444	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80752
delsoline-5858	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52762
hsa-miR-589	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20867
NBR1	Pathway Commons Protein-Protein Interactions	1.0	null
nasopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.243605
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62573
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32192
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00312
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51123
nordihydroguaiaretic acid-1061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
stage	GeneRIF Biological Term Annotations	1.0	null
BRD-K30821056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02219
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12442
Spinal nucleus of the trigeminal, oral part, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02503
BRD-K31121304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10364
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948808
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13578
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2057
CLIC1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A28153253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02269
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hFOB 1.19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.953612
GSE146070_1_v_0_edem3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.956742
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865156
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.495701
TROVE2	Pathway Commons Protein-Protein Interactions	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	1.45734
TFEB	ChEA Transcription Factor Targets	1.0	null
RPL10A	Pathway Commons Protein-Protein Interactions	1.0	null
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02297
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4423-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22537
gastric cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267102
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03847
RFX5	ENCODE Transcription Factor Targets	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.995497
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.993727
E2F1	ChEA Transcription Factor Targets	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831361
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26208451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15418
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
BRD-K27109474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58854
hsa-miR-3613-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-A41916216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32696
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
EB-66-IH06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283722
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288796
CRCGN013_HEPG2_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83787
ANKRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12956
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62909525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2814
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.980886
BRD-A05883068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61283
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NR3C1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02712
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03941
superficial stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09926
H3K9me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HT115	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SRSF7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4478	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Perturb_15192_OE_LEF1_SRP406316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.2774
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.30589
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19181
MORN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06576
hsa-miR-301a	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225097
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clotrimazole-6207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SERPINB2	Pathway Commons Protein-Protein Interactions	1.0	null
GPC6	Pathway Commons Protein-Protein Interactions	1.0	null
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04752
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Boc-4mesyloxypiperidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
Growing cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226833
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PURA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
meteneprost-7500	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861752
predictor	GeneRIF Biological Term Annotations	1.0	null
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_U2OS_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.827323
20421987-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27197
RSL24D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31333
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.836
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517705
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.9337
within	GeneRIF Biological Term Annotations	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.736301
BRD-K02299361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64469
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.652576
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10342
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH2405	CCLE Cell Line Gene Expression Profiles	1.0	1.63742
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47325
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE40_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIP	Pathway Commons Protein-Protein Interactions	1.0	null
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07567566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32079
hsa-miR-454	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
years	GeneRIF Biological Term Annotations	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
clonidine-6814	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-DX-AB2Z-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311016
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.85768
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79182
8317_SPAG7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575232
translation	GO Biological Process Annotations 2025	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.84023
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56188108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27242
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200916
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22421
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33063
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.892275
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41045
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867353
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K96713984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07167
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23044
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833541
Cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CIZ1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.508242
Perturb_15015_KO_Irf8_SRP265130	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
multicellular organismal reproductive process	GO Biological Process Annotations 2015	1.0	null
BRD-A73590800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01269
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884173
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.3453
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.532
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleic acid-binding, OB-fold	InterPro Predicted Protein Domain Annotations	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964693
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fulvestrant-1205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58953
12734205-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKUT1	DepMap CRISPR Gene Dependency	1.0	3.72521
KYSE180	CCLE Cell Line Gene CNV Profiles	1.0	1.42767
isoconazole-5857	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2278
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965469
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897592
Pancreatic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043746
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05606
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37416
duodenum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182435
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374592
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.03552
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT24	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040669
uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.588031
GSE143212_0_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.742
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10536
Lung squamous cell carcinoma_LUSC_TCGA-56-8308-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14217_KO_Mecp2_SRP061339	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.7016
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
PEF1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06284
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
TNRC6B	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eif5a2	GeneRIF Biological Term Annotations	1.0	null
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08298
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
Perturb_12324_KD_PHF20L1_SRP188318	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hsa-miR-134	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
BRD-K04163641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45481
SMC3	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863516
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4251	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
16232197-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915422
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
flunixin-4273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07361992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12165
RDES	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66599
Perturb_8699_KD_FTO_SRP213118	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.1643
Interstitial cell of Cajal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
sulfathiazole-4769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CARM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87053028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.67156
GSE132948,GSE132949_2_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65452
PGK1	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926894
updating	GeneRIF Biological Term Annotations	1.0	null
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAFAH1B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50807
BRD-K15393664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08026
TNNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45934
TBX5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71738
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09472
monastrol-596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848169
BRD-K00797068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00639
HPRT1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Tazarotene2	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
positive regulation of translational termination	GO Biological Process Annotations 2015	1.0	null
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.83444
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.158
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73485
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21907
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49005954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6079
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299227
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876916
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443948
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLCPRF5	CCLE Cell Line Gene Expression Profiles	1.0	1.40044
BRD-K70262646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00109
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36733
BRD-K24538875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46631
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K23085156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26436
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40878
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5019-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
r7 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14605
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-8_DEGs_RUNX1-OE_vs_control-Gene_Symbol_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10531
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.99432
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239077
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45114
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193027_1_v_0_krt19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85359206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69001
IRF1	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293474
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4421	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19138
hsa-miR-519c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
PCDHB15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71108
PHF8	ENCODE Transcription Factor Targets	1.0	null
Ripasudil	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
NCI-H810	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53161
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3165
QA-14-AU91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202865
focus	GeneRIF Biological Term Annotations	1.0	null
RAB15	Pathway Commons Protein-Protein Interactions	1.0	null
Malignant Tumor Of Cervix	DisGeNET Gene-Disease Associations	1.0	null
ionomycin-979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AGO1	Pathway Commons Protein-Protein Interactions	1.0	null
PTMA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF2-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
ATF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mrna transport	GO Biological Process Annotations 2015	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57907671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56387
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47143
CFPAC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.095
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2139
TGOLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00259
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279554
EKLF-21900194-ERYTHROCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.80753
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.943485
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350145
MYO9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24346
smooth muscle	HPA Tissue Gene Expression Profiles	1.0	1.3349
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17882
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227562
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7719
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARID1A_01_109	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.78255
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45503385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20773
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.859773
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03847
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26435104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07292
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36714
HOP-62	GDSC Cell Line Gene Expression Profiles	1.0	1.47315
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SHROOM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46946
PF-01378883-00-6368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
CCBL2	Pathway Commons Protein-Protein Interactions	1.0	null
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318506
NIPSNAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inferior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.877144
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
MYCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
GOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07777
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.776164
Lung adenocarcinoma_LUAD_TCGA-38-4629-01A-02R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11636880-41408_2024_1041_MOESM6_ESM.pdf-2-EGR2_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29016
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14493
BRD-K14589361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27025
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4627-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spermatogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06268
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
KRT75	Pathway Commons Protein-Protein Interactions	1.0	null
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1205	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4032
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08639
hsa-miR-4255	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.33406
SW-620 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.087
RET_knockout_270_GSE32093	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6847
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.980501
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2693-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Papillary thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
nuclear part	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K50510710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65328
GSE151612_0_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.294
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EF-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-655	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
duodenal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.50942
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51189
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.93211
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863516
Paragigantocellular reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11225
NMuMg cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
NCIH1755	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3968
Gall bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
SARS-CoV MA15_Day7-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.27908
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8473
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Motor nucleus of trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05379
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32052
BRD-K97445906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06939
uterus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.930809
H3K9me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NEDD4	Pathway Commons Protein-Protein Interactions	1.0	null
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35921
DSH1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.66625
GRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8041-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.934911
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223573
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961398
eldeline-2171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-320a	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5ML-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56437119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0306
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30581008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.44796
BFTC-905	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
RMUG-S	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKHEP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.546
nucleobase-containing compound transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
kanamycin-3224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-519d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
butein-607	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SF295_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.2295
ELF1	ENCODE Transcription Factor Targets	1.0	null
EIF4E3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03608799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00808
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.385143
hsa-miR-4513	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35753
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27186
BRD-K92725027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69199
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24457
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89376690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15927
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STK3	Pathway Commons Protein-Protein Interactions	1.0	null
nasopharyngeal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141234
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938923
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3805
hsa-miR-3133	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
hsa-miR-549	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
HNF4A	ChEA Transcription Factor Targets	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DV90	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77573
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943294
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.08022
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064698
Adrenocortical carcinoma_ACC_TCGA-OR-A5K5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prochlorperazine-995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92985
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4504	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
elevated	GeneRIF Biological Term Annotations	1.0	null
isotretinoin-6017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nocodazole-6793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulated	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4727-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Perturb_12529_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.1093
KLHL12	Pathway Commons Protein-Protein Interactions	1.0	null
PLS3	Pathway Commons Protein-Protein Interactions	1.0	null
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD4	ENCODE Transcription Factor Targets	1.0	null
rostral putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951004
LGALS3BP	Pathway Commons Protein-Protein Interactions	1.0	null
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.869981
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastric cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.599
GTEX-RM2N-0826-SM-48FD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14379
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.3878
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
M040416	DepMap CRISPR Gene Dependency	1.0	2.2606
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23514
Gallbladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
Pharyngeal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.222
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UPCISCC152	DepMap CRISPR Gene Dependency	1.0	2.62644
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_NK_cells-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kmoe2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.08
PMC6580320__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
DGAT2L7P	Pathway Commons Protein-Protein Interactions	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830241
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368872
A549	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46843
homeostatic process	GO Biological Process Annotations 2015	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.36524
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8851354-Table_5.xlsx-FUS-DDIT3_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_FUS-DDIT3_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
cell leading edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.16298
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24909
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Stage 0 Gallbladder Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-526a	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23151
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A53850583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19034
cell part	GO Cellular Component Annotations 2015	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274261
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17468
Perturb_14960_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.58662
Eltrombopag	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51121
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.439786
STK416816	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
Arnt::Hif1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2212
Gamma carboxylation, hypusine formation and arylsulfatase activation	Reactome Pathways 2014	1.0	null
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Mutation Profiles	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936667
meteneprost-7504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pretectal nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93415
NFYA	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
hexylcaine-5768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	2.1428
non-membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
KCTD17	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H510A	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
CRCGN015_MCF10A_48H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68249
Perturb_17359_OE_CREB_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.27607
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13783
Gastric cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.216
H2731	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3157-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
COGN278	DepMap CRISPR Gene Dependency	1.0	2.16921
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGHM	Pathway Commons Protein-Protein Interactions	1.0	null
PCBD1	Pathway Commons Protein-Protein Interactions	1.0	null
smoothmuscle_8c	HPA Tissue Sample Gene Expression Profiles	1.0	0.953224
meclozine-2424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75424
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29298
hsa-miR-1279	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14621
TRIM21	Pathway Commons Protein-Protein Interactions	1.0	null
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31554491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0769
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.624
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75293299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26873
colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.271952
BHLHE40_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79517375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76117
adenosine phosphate-5359	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SERPINB4	Pathway Commons Protein-Protein Interactions	1.0	null
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
RXRA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912613
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.325916
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825003
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06936
HCFC1	ENCODE Transcription Factor Targets	1.0	null
r6 part of spinal trigeminal nucleus, pars oralis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07212
Perturb_4217_OE_Hoxa2_SRP092451	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.7146
BRD-K22093396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1222
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22949587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25885
regulation of translation	GO Biological Process Annotations 2015	1.0	null
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941218
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964331
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
root	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.110771
PFN2	Pathway Commons Protein-Protein Interactions	1.0	null
EMTOKA	DepMap CRISPR Gene Dependency	1.0	4.70772
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30243
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904661
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7501_KD_EP300/YAP1_SRP193326	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.23878
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75699
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Spinal nucleus of the trigeminal, oral part, rostral dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11493
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.98478
BRD-K21996934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1195
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE141624_3_v_6_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	2.73402
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.935907
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.867
vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44317
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.88004
Lung squamous cell carcinoma_LUSC_TCGA-21-1071-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE222500,GSE222501_1_v_0_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXK2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.174
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19100834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04711
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41436
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HT-01A-61R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5242
isoforms	GeneRIF Biological Term Annotations	1.0	null
BRD-K45537529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39784
SKMEL28	CCLE Cell Line Gene Expression Profiles	1.0	1.85699
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.012
GTEX-WFJO-0826-SM-4LVM5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09012
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36294
Nasopharyngeal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
PRDX4	Pathway Commons Protein-Protein Interactions	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38138
CRCGN016_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15727
hsa-miR-1206	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3695
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22225
Perturb_8696_KD_Sam68_SRP373391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.87751
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10039
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.032
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS14	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19036
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79374
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.839857
WDR77	Pathway Commons Protein-Protein Interactions	1.0	null
GSE244199,GSE244200_0_v_1_chmp5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20626
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BICR22_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	5.82358
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51571
H3K27me3_iPS-20b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062006
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VHL	Pathway Commons Protein-Protein Interactions	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF217	ENCODE Transcription Factor Targets	1.0	null
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02665
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ticlopidine-1475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF7L2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17509_KO|OE_TP53_SRP316424	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54382
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849416
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
skin	HPA Tissue Gene Expression Profiles	-1.0	-1.06021
Small intestine cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08281
tranexamic acid-2085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74324157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84358
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19918
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRIM41	Pathway Commons Protein-Protein Interactions	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic ductal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.02
NUP88	Pathway Commons Protein-Protein Interactions	1.0	null
GSE195559_8_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61796560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15488
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961398
BRD-K44212150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08819
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45062933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15346
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
N6022	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A25537246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96137
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cochlear nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43673
WBP2	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-DX-A8BS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00698280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61307
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.913
RCOR3	ChEA Transcription Factor Targets	1.0	null
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.557263
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of parvicellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00588
doxepin-2384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT17	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_167_KO_Itgb3_SRP305656	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.61513
ubiquitous	GeneRIF Biological Term Annotations	1.0	null
BRD-K86586698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06524
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2
ptma	GeneRIF Biological Term Annotations	1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02785
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecule biosynthetic process	GO Biological Process Annotations 2023	1.0	null
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08922
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24586
Perturb_10308_KO_Pkd1_SRP128475	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.40994
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.0458
SW-780 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
2-PMPA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
suramin sodium-7524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HIST1H2BL	Pathway Commons Protein-Protein Interactions	1.0	null
exportins	GeneRIF Biological Term Annotations	1.0	null
ACTN1	Pathway Commons Protein-Protein Interactions	1.0	null
clozapine-1009	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nuclear pore	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12691
napelline-6824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SKNEP1	DepMap CRISPR Gene Dependency	1.0	4.97162
MDM2	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525955
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
isoetarine-2711	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ACOX1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49011
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.868834
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29032
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39101
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28435
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RASSF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63134971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85958
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04356
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.553944
GSE166536_0_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
GSE133213_10_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.655
BRD-K22875065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52316
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26701
KBTBD6	Pathway Commons Protein-Protein Interactions	1.0	null
Liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.11
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
overexpression	GeneRIF Biological Term Annotations	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAPAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
18535662-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
CTSA	Pathway Commons Protein-Protein Interactions	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401629
intracellular part	GO Cellular Component Annotations 2015	1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
positive regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10342
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42127
BRD-K91620436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46461
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL28	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3065-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.840931
SKMEL5_SKIN	CCLE Cell Line Proteomics	1.0	6.72574
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95737
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM3	Pathway Commons Protein-Protein Interactions	1.0	null
E2F1-21310950-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92364
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999052
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.668192
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24223
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
causes	GeneRIF Biological Term Annotations	1.0	null
T47D	CCLE Cell Line Gene CNV Profiles	1.0	1.50409
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57555
FOXK1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72773
hydrocotarnine-6827	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
indapamide-4335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
S100A16	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21124684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24946
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19513
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081858
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KNS-62	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
Sarcoma_SARC_TCGA-SI-A71O-06A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD4_druginhibition_224_GSE50865	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.32763
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Photosystem II reaction center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.019
Tumor Vasculature	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_1310_KO_Cntnap4_SRP387040	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.87207
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.228
BRD-K37253893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28336
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.491
Perturb_3399_KO_Tcf7_SRP077563	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.47244
hsa-miR-3908	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
km3	HPA Cell Line Gene Expression Profiles	-1.0	-1.68688
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242541
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_2_vs_Type_3-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bacitracin-7448	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21001
hsa-miR-1283	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11394_KD_USP7_SRP292689	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perindopril	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.6
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885324
786-0	GDSC Cell Line Gene Expression Profiles	1.0	1.82634
moracizine-7297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DENND3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ANXA7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83122599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19885
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269889
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90473
BRD-K09779858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94509
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111348
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.381755
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857959
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4269	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17852428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0552
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07996
r2 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2504
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12863
Maraviroc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
TENM3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38946705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.761
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557359
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4919
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41903
BRD-K74056311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24232
Extrachromosomal DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.999
Perturb_7046_KO_miR19a/miR19b1_SRP050491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.77134
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.978276
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01292
PRDX6	Pathway Commons Protein-Protein Interactions	1.0	null
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.652994
SEC24A	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABHD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44663
TE-6	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296405
ZNF580	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10826
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18932
ZNF605	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24377
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1662
PPP2R2B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7399786__F7	PFOCR Pathway Figure Associations 2023	1.0	null
EIF2B2	Pathway Commons Protein-Protein Interactions	1.0	null
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07634
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-106b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.7401
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064024
Starch grain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.703
GSE239844_1_v_12_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLG2	Pathway Commons Protein-Protein Interactions	1.0	null
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06176
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JHUEM7	DepMap CRISPR Gene Dependency	1.0	10.9978
ACTBL2	Pathway Commons Protein-Protein Interactions	1.0	null
TRIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60204
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2811
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1323	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Anophthalmia And Pulmonary Hypoplasia	DisGeNET Gene-Disease Associations	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16917
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
ELK1	ENCODE Transcription Factor Targets	1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3879
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11179
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22434
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.960182
SP4	ENCODE Transcription Factor Targets	1.0	null
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3450-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
metformin-1694	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66898
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSN	Pathway Commons Protein-Protein Interactions	1.0	null
PCI-34051	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442986
CAL-85-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.283
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5946
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08345
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04061
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZK-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.9276
cytoskeleton	GeneRIF Biological Term Annotations	1.0	null
BRD-K74500173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08219
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724505
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spinal nucleus of the trigeminal, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01942
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22725
hsa-miR-588	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
Quetiapine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09287
Lung squamous cell carcinoma_LUSC_TCGA-46-3768-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Plasmodesma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
tranexamic acid-6238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51015
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Carcinoma, Ovarian Epithelial	DisGeNET Gene-Disease Associations	1.0	null
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
hsa-miR-649	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
MPP1	Pathway Commons Protein-Protein Interactions	1.0	null
Glyoxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.684
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
Malignant ovarian surface epithelial-stromal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
Esophageal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.585
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A86F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
FU97	DepMap CRISPR Gene Dependency	1.0	2.57012
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR1H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54466
hsa-miR-2278	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
ARID3A	ENCODE Transcription Factor Targets	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06284
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0315
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2423
STOCK1N-35874-6561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
hsa-miR-3662	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.978
hsa-miR-4692	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
rna binding	GO Molecular Function Annotations 2015	1.0	null
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
mycophenolic acid-2857	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hif1alphamediated	GeneRIF Biological Term Annotations	1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	1.0	2.76235
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03615
adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.260184
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22928
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23303
BRD-A20314546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31618
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8702
Lung squamous cell carcinoma_LUSC_TCGA-66-2800-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF638	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11703
SRSF5	Pathway Commons Protein-Protein Interactions	1.0	null
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_17533_KD_C1QBP_SRP270881	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
LY-294002-5587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27126
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metabolism of proteins	Reactome Pathways 2014	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889258
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10393
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87167435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13645
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36119
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828799
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6925
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AA-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tongue cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.843706
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
TBK1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15434
TNFAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0219
BRD-K81001899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44807
BRD-K79768278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59639
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43399
hydroxylase	GeneRIF Biological Term Annotations	1.0	null
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.99643
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059906
clomipramine-6825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095946
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07143
mta1	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid gland anaplastic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
aminoglutethimide-2390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAPK1_knockdown_45_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.86984
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90618
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.023
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.877125
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863619
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.53431
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.94664
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93023309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27335
PMC7399786__F7	PFOCR Pathway Figure Associations 2024	1.0	null
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4892
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39495
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09838
CLTCL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76861469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6974
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6859
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
activin ab complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.67463
MYC_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.1473
BUB3	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837211
REST_01_337	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59838
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10791
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15504
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88635
ATG3	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18299
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.2911
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.680374
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962335
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4295	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
stomach_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.33693
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_13664_KD_WIPI1_SRP299893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Acute Myeloid Leukemia_LAML_TCGA-AB-2912-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.7713
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KYO1	DepMap CRISPR Gene Dependency	1.0	2.62226
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208799
HSPA6	Pathway Commons Protein-Protein Interactions	1.0	null
PTP4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90411
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81974
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0595
PMC5749161-supp_gad.305813.117_Supplemental_Table_S2.xlsx-CLOCK_DEG_database-Supplemental_Table_S2_Differentially_expressed_genes_database_and_gene_set_intersections_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.05275
eif5aii	GeneRIF Biological Term Annotations	1.0	null
496100351_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41459
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
NCIH2172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89061
MAT2A	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.143
BRD-K24848743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59632
5637 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
8505C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.258
hsa-miR-301b	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3686	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
noretynodrel-7471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
MYCN	ChEA Transcription Factor Targets	1.0	null
IQCB1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.006367
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8502-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.75198
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-369-FOXF2_FOXF2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-7643-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
17952126-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
MAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73723329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14261
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916631
CSTB	Pathway Commons Protein-Protein Interactions	1.0	null
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260406
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36516
RPL18A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVUS-0626-SM-447CC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873877
NCI-H2052	GDSC Cell Line Gene Expression Profiles	1.0	1.93224
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04079
KLF1	ChEA Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colo320dm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
clinical	GeneRIF Biological Term Annotations	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
aminophylline-6295	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.592444
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GM133	BioGPS Cell Line Gene Expression Profiles	1.0	1.62772
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.902864
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30333
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.931457
CBX3	ENCODE Transcription Factor Targets	1.0	null
GATA2_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDK1_knockout_265_GSE42187	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.52198
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pirenzepine-5872	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26011
hsa-miR-4717-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DNAJB1	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of cell proliferation	GO Biological Process Annotations 2015	1.0	null
Perturb_15120_KD_LSD1_SRP331013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.5915
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
HN-30 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
PMC7338542-41389_2020_247_MOESM5_ESM.xlsx-BRN2_2_of_3_UP_48_h-Symbol_POU3F2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-494	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K78828094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2962
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950553
BRD-K58753007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40268
stimulates	GeneRIF Biological Term Annotations	1.0	null
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
lys	GeneRIF Biological Term Annotations	1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.534251
SAP30	ENCODE Transcription Factor Targets	1.0	null
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.874168
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
H3K9me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_4000_OE_LIN28A_SRP096196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.91935
PRPF39	Pathway Commons Protein-Protein Interactions	1.0	null
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39710695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11593
NFE2	ENCODE Transcription Factor Targets	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21842
BRD-K47754225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13434
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.703127
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05399
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241662
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981666
feature	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21996189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04646
CWR22-Rv1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
EEF1A2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QXCU-1926-SM-48FE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11406
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61856
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.49808
ATP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48925
esophageal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565232
Perturb_146_KD_Mettl3_SRP033779	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.36196
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29879
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852905
Carcinoma Of Bladder	DisGeNET Gene-Disease Associations	1.0	null
primary visual cortex (striate cortex, area V1/17)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50155
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11349
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10574
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-599	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SALL4-18804426-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06609
H3K9me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Urothelial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.97093
GSE174383_1_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3571
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-RUNX3_mod_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40241022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12648
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47690679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08082
Perturb_6672_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
valdecoxib-6378	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ALDH2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02448
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.931515
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10318
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	1.0	0.917002
metastatic	GeneRIF Biological Term Annotations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6060_KD_RBMX_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.52989
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
none	GeneRIF Biological Term Annotations	1.0	null
BRD-K34942615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29563
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47389
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.883418
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
17724462-TableS2	GeneSigDB Published Gene Signatures	1.0	null
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967029
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323744
GTEX-VJYA-1026-SM-4KL21	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910393
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
RNAi effector complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.326
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHU-011	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331251
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.94
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TUBA3C	Pathway Commons Protein-Protein Interactions	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5750_NOP58_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539522
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate (interpositus) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00743
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.344
Perturb_11631_KD_HSPC182_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.73954
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12712
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-615-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6009
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15368
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75478
USP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68338
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IQSEC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amplification	GeneRIF Biological Term Annotations	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.987198
ALB	Pathway Commons Protein-Protein Interactions	1.0	null
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20681
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318281
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.849265
CALU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64952
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
DU-145	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44145
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896576
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-320d	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
ECH1	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096281
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S100A11	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
post-translational protein modification	GO Biological Process Annotations 2015	1.0	null
PMC11185762-media-2.xlsx-ATAC2wk_KD_V337M_intersect_peak-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05663
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12415
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU5F1-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.69316
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2828
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23018
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4E-Supplemental_Table_S4E_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_MCF-7_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
bethanechol-3537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-770-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369717
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29793