association	dataset	threshold value	standardized value
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.995
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539768
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03205
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843367
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465566
KLRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00816
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.805142
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.89762
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00562
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.865882
KYSE-220	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20991
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Purvalanol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GTEX-U3ZM-0926-SM-4DXSW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32073
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221655
GE-84-VZ24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220323
Cytoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.392
SK-LMS-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.65767
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
1483_CENPJ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529468
GTEX-U3ZH-0226-SM-3DB7B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851423
PACS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40676
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YE-55-YX75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.75548
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05477
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U4B1-1426-SM-4DXTX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13644
DDX42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35432
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.904613
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478219
GTEX-PWOO-0926-SM-2I3EC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20891
WNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02162
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.861197
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.746171
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400137
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0109
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0091
7426_RPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.740646
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.617522
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583962
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231384
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601756
NFRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35993
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03871
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74108
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515553
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.714002
GTEX-T6MN-0726-SM-32PML	GTEx Tissue Sample Gene Expression Profiles	1.0	2.6229
GTEX-XXEK-1326-SM-4BRV1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838362
AE-04-SN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278396
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	1.0	2.0461
2225_UTP25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593037
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12999
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906977
GTEX-VUSG-2226-SM-4KKZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10394
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55495
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10616
5673_NIP7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529316
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01945
5602_NEMF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502754
lm7	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.849459
9212_TPRKB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.802237
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951016
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47921
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38446
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858422
IF-31-RN78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19273
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2906
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
16_AATF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.646146
H3C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08637
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8744_TBRG4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621714
7539_RPS9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.596606
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03463
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.15
GTEX-PWOO-2526-SM-2S1PG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898729
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827154
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06211
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06369
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21353
GSE155031_5_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.0682
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.903406
9839_WDR74_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622302
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93456
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311303
5733_NOL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.613556
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12695
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2973
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29781
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26371
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546391
GTEX-XGQ4-0126-SM-4AT4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13208
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4116
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18039
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06337
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.644272
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5163
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
4472_KRR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.639934
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07173
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849502
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.766914
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79559
CPSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92679
TDRD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15664
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839919
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23963
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19576
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235819
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.801105
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.937297
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532714
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7398
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-850-ENSG00000181894_ZNF329	Rummagene Transcription Factor Associations 2026	1.0	null
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246314
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75428
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20356
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.665456
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268242
10016_ZBTB9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52544
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657002
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642627
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49378
Adult T-cell lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.427
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.93879
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1381
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852691
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95311
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31278
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00846
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04347
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.327
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591975
GTEX-WH7G-1726-SM-4LVKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87486
2051_DCAF13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.766033
GRINA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33552
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33795
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
C15orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01809
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21747
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.761582
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.771258
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1442
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.89702
11294_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.781121
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930221
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63442
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980794
CHAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15286
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.72076
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252916
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943836
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.572222
CCNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13559
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.772453
NFE2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38377
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936063
2580_EIF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724243
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.770757
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09685
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899528
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92995
TSEN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35136
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35991
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00244
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904607
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23119
8653_TAF12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0053
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.961264
DCAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87788
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382472
ZNF746	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33093
TSC22D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06099
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.716322
GTEX-OHPK-2626-SM-2HMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981799
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16332
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ABHD17C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10669
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03999
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.883605
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03546
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.039
3395_GLIS1_ENST00000312233.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.711318
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.85632
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	1.0	3.02904
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.698289
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.790776
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96803
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950019
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16191
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.86803
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221738
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40938
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37677
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19432
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04735
GTEX-SJXC-2026-SM-4DM6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40234
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04847
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01635
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62326
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933451
GTEX-S95S-1026-SM-4B64M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37683
KYAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01961
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.485423
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722706
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516746
Ocular melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.9838
ZSWIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57121
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392488
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74997
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205986
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20166
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.98666
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959059
QF-00-CY91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261391
EIF4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10225
GTEX-XUZC-1026-SM-4BOPY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863545
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05675
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.968177
1365_CD3EAP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568632
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52784
6221_PET117_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505852
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09685
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37548
GTEX-SNOS-1026-SM-4DM4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847329
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04696
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.40456
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04375
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04945
U2AF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6929
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10118
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32872
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.711601
GNA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05858
2544_EIF3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.560753
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.540395
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894704
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.71066
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89373
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.915716
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6024
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887412
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08649
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06535
i10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01295
GSE207301,GSE207303_1_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
2553_EIF3I_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61357
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881454
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.531855
GTEX-QXCU-0626-SM-2TC69	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976412
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.11831
TRIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03206
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33194
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24302
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.831252
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.617707
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19267
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15648
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35423
3445_GNL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569837
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21499
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557011
NKTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3035
1192_CARF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554741
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06191
GTEX-XBED-1626-SM-47JYN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830999
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80519
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.64414
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27861
8622_SYNCRIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514825
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0735
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527397
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886674
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.936043
ZDHHC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02264
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551434
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_5_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49295
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564387
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
COQ5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21688
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59826
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30131
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.518654
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TENM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28239
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09685
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95037
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.83384
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51831
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.909329
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.872581
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
P005091	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2947
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.036
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253492
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9974
ELAVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21414
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245338
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08999
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DMXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17363
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75277
GSE246335_4_v_5_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2767
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01381
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.660535
ZNF616	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87961
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.44125
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57491
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562407
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10221
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78953
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83386
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.997864
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.61373
PMC11216188-peerj-12-17616-s013.pdf-332-ZNF154_ZNF154	Rummagene Transcription Factor Associations 2026	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52042
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53445
9816_WDR36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598823
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15578
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18046
OVCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00897
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02015
GTEX-RWSA-1126-SM-2XCAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892367
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622363
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.406
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.820869
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
AASDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47636
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24833
GTEX-POYW-0426-SM-2XCEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829889
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25024
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840774
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.680035
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.288
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.64815
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2328
GSE174701_5_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80236
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272693
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.33079
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.571744
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.828561
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59453
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682602
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPATS2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20491
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.905246
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4889
Alfuzosin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293311
Rosiglitazone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14453
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.935604
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.4513
GTEX-QESD-0626-SM-2I5G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53741
PRKCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11655
4110_IMPA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622986
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531668
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.722614
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.874455
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09749
3385_GLB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51644
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3843
5365_MYBBP1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564406
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2139
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5319
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9546
ARHGAP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16646
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13723
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.981172
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0081
AC-92-HS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00103
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.626153
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881972
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307902
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73793
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.806499
7713_SDAD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534852
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
2789_EXOSC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.816306
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25059
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49505
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.03979
SAR7334	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6904
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02502
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.999
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42681
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952117
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228973
7723_SDHAF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.631021
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04555
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885327
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909643
PCI-15A	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.23385
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590921
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5039
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.449
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7108
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76096
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.632563
GART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03097
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875001
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.82882
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Basimglurant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2745
Bexarotene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.892096
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43175
8656_TAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614339
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262663
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3916_HOXC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528221
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36811
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92934
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14364
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981195
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29199
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.710424
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489377
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.922349
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.469026
9364_TSR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519395
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.960767
20077526-TableS4	GeneSigDB Published Gene Signatures	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15578
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50577
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45615
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.18484
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518506
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60273
chr19_58315168_A_G_b38	GTEx eQTL 2025	1.0	1.05723
9820_WDR43_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503204
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927737
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21976
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10598
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955467
PMC10679653-mmc2.xlsx-ISL1_KO_Markers_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64176
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10305
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09021
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.844846
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3505
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0245
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.82906
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09949
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533754
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.740281
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57956
AGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20013
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29531
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7844
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
HINFP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21853
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02039
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.903125
REXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00783
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.22428
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624812
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49837
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23516
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31079
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348521
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06638
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
3797_HIVEP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563541
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48711
GTEX-Q2AI-1126-SM-48U19	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91668
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06294
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19537
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50095
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42064
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.783695
GTEX-RWSA-0826-SM-2XCBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3814
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233981
4384_KIF20A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533642
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3152
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78524
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.776906
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96313
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923573
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15013
5702_NLE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574592
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02431
Rolapitant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11733
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.84257
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.72692
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.789462
GTEX-U4B1-0526-SM-4DXTK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06959
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36708
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.65429
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.988815
ZBTB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88295
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43568
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09888
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57415
GTEX-V1D1-0926-SM-4JBHQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853064
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9837
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16286
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.832535
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09685
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68067
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WRHU-0926-SM-4E3IG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30094
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18702
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.848
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35074
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.8636
8658_TAF1C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544208
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19786
Fevipiprant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7719
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.802647
GTEX-PWN1-2626-SM-2I3FH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18268
MMACHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68544
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67078
SB-09-JU93_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478996
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00093
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCFC1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00701
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.802466
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17874
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24778
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6114
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07746
CENPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09431
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20109
6576_POP5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.756561
8405_SRFBP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540626
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981536
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856413
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886981
Pyrene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3068
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21891
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42207
1301_CCDC86_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.758736
ATF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51094
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46798
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.039
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963193
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.24759
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30113
7480_RPL8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.796959
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24946
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.675211
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10959
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20166
DCPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64007
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0643
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.608614
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207439
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2593
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882085
Astrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938118
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.690869
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04188
7481_RPL9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.707797
GTEX-QCQG-0226-SM-48U28	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42555
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977806
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.78161
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834792
SB-222200	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262959
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887152
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22634
NUDT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44053
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
KM-H2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
DAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41067
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41719
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32747
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33746
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830951
GTEX-SNMC-0926-SM-4DM5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76506
4921_MDN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589101
7460_RPL32_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545456
GTEX-T5JC-2126-SM-32PMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89935
GSE120612_6_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.90257
6509_POGK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528144
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20431
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.44175
PMC12079334-ADVS-12-2501734-s002.pdf-198-ENSG00000171425_ZNF581	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.995826
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.657683
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896058
5074_MIIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.908644
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375032
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3948
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.1367
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.737938
3882_HOOK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532077
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847613
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32731
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39176
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.728216
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91361
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49059
GTEX-X4XX-0926-SM-46MV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2367
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
1129_SPOUT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552901
ZNF524	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51606
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03783
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16561
LSM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57843
GTEX-S33H-1826-SM-4AD65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47595
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.796284
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01891
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2IS-0626-SM-32QP6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860946
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.1393
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.910002
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298099
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02185
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5682
MPHOSPH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47613
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8947
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504354
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8864
DPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6713
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27318
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425104
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50557
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08673
1614_CINP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.632267
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8284
GK01981	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698301
PMC9229595-Table_2.xlsx-LPS_subset_IX-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
2129_DDX54_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61249
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.735754
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474573
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471163
PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
2546_EIF3CL_ENST00000380876.4,ENST00000398943.3,ENST00000398944.3	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.56247
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12218
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3662
7559_RRN3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.770295
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0916
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.24502
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03436
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926312
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33383
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00615
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34604
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867549
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915754
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00741
GTEX-X4LF-0426-SM-3NMB5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942629
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502246
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20398
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302569
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696627
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HEY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03144
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850535
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71792
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.44738
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844179
GSE157894_2_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02438
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29985
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04764
GTEX-OIZH-0626-SM-3NB1L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888848
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71807
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79157
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97708
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917357
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3106
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7460_RPL32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555068
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36054
7521_RPS29_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545738
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.18484
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20449
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20166
6793_PRPF31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519823
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891049
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95123
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0018
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.902718
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207647
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2614
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09303
Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.641356
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2865
GTEX-OXRP-0326-SM-33HBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870955
GSE135514_8_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467222
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.832639
9798_BUD23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630721
DA-58-LZ09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222868
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88108
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835762
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09032
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02438
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0924
2556_EIF3L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.573566
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965922
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70902
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24462
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556727
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36421
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834416
C2CD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08412
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.806381
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01767
GALNT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05693
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04341
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13597
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.688937
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8001
HIPK2_defectivemutant_29_GDS4233	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.29493
XB-22-LI07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232034
2550_EIF3F_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.801822
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00653
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36634
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06006
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.610638
MC-51-BT07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203313
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHMP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55008
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6506
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76098
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
wehi164	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878748
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLITRK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22792
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45364
1148_CACTIN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.555353
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862135
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880742
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.21714
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11412
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2422
ZRANB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39771
Glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.971
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624058
GTEX-XYKS-2526-SM-4BOPX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01544
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05321
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504814
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10587
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952117
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617979
PPP1R14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50857
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480645
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968328
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242083,GSE242098_3_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963196
7311_RIOK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609624
GTEX-U8XE-1026-SM-4E3HM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848759
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186440,GSE186443_6_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AH-0226-SM-48U1I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09063
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556093
H4 neuroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GPRC5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06428
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.646707
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14753
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.773291
6575_POP4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677894
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.12914
Turofexorate	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
SERTAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22074
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54013
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.61702
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73344
ZNF789	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91925
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539121
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14741
RNF170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15186
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.660635
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0649
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.25112
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05257
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.731318
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61444
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.798786
BMS-911543	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
1667_CLNS1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520506
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.966
ATP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00089
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.987253
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39936
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15578
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01798
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
3504_GPN3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623927
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.752276
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17012
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38511
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55711
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962853
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.600646
5707_NMD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.678836
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.708514
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.80434
GSE159678_4_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-02-BO83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222595
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.07598
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76709
AA-39-BD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.615358
5730_NOC3L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500816
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6666
SPTLC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30836
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STK832240	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GTEX-QDVN-2226-SM-2S1PM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859883
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85331
Pituicytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206612
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18357
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.824503
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72484
GTEX-XMK1-1026-SM-4B65H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835432
GTEX-SN8G-1526-SM-4DM79	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985084
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982289
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26534
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280326
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155031_6_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03682
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.681621
AA-79-SX47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220775
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04021
Korean hemorrhagic fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06515
NU-DUL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98459
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF211	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01698
UA-39-TN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300084
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.62026
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08947
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89398
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41628
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1474
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41651
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52315
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43609
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91726
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.90629
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58167
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46986
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898725
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918528
Pineocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.13201
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226892
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979351
GTEX-N7MS-2326-SM-2HMLD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34723
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92468
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887922
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.92946
5487_NCAPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51062
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840811
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.711909
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.04305
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12553
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873742
GTEX-XLM4-0726-SM-4AT64	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950909
C6orf136	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20065
GSE217541,GSE217543_3_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270797
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2462
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.776563
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42371
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55058
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.539123
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831245
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-401-ZNF329_ZNF329	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971966
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1296
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.986011
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374357
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81077
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.865216
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999411
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_1_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
b95.8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303662
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.067
GTEX-SIU7-1126-SM-2XCDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03895
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.977768
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238514
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BTN3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7059
2114_DDX27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.622744
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03152
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924013
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845166
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20287
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.935604
AZ505	DeepCoverMOA Drug Mechanisms of Action	1.0	3.3
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.774711
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30833
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904321
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.118
7433_RPL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.553079
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982493
6642_PPM1G_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.720703
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.731364
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44473
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25986
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.554471
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966913
GSE161302,GSE161304_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TNFAIP8L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20293
2129_DDX54_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581296
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95123
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09685
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75127
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318605
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07835
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1529
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30625
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432499
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19272
GSE158438_4_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5112
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30207
Oligodendroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
ERVK3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50502
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46821
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
10755_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.505278
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39254
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59468
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14936
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.83241
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
UF-28-DW05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262897
SK-N-DZ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49312
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218091
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981981
9629_ATP5MD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541901
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23726
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.733753
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244108
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1424
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505084
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16682
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4898
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7437_RPL13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.622301
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.816517
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.674833
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
608_ATF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560446
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53294
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66649
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580017
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01377
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.93879
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63534
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904991
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Meningioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66372
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0333
Bestatin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.846243
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04173
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868838
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396766
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9501
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523652
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84411
PPP1R16A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42513
STK410283	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.73
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Defactinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.56
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30977
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08673
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449177
DMAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08522
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00638
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3927
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09063
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37403
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.528649
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57514
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.35862
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4637
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
7497_RPS10-NUDT3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609737
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.77244
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35016
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.641646
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.973816
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.62316
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17625
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57346
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345943
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983012
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.51437
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970507
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370428
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397502
GTEX-XXEK-0126-SM-4BRVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45651
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36353
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08911
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21313
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.589089
2111_DDX21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529923
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29199
8325_SPATA5L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503676
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22529
NEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38589
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896986
CSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01652
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.50381
hdlm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.44
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946894
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.26381
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.49838
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03627
990_MOSMO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52807
GSE157557,GSE157559_1_v_0_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30182
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825444
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834992
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-2826-SM-4B65I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86585
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23765
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828289
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49548
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06893
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04212
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878638
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NFK9-0726-SM-2HMJW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999569
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.53168
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.613193
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10959
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40934
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95123
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52257
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12381
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03704
6980_PYURF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560124
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8249
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30566
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.62649
LCLC-103H	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.81977
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91361
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1569
GTEX-XUZC-0126-SM-4BOO6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13317
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3312
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26865
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0322
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868829
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952117
STK368746	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0324
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996541
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.666581
9679_UTP11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662631
FOXD4L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76748
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35464
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824096
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897616
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05739
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7209
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846628
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642944
8660_TAF1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.691677
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.35333
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.689343
G118	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58596
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213739
Rifampicin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intraventricular meningioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47067
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67078
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53262
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38239
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963799
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.915442
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.895569
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.678501
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07547
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.91957
RFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49919
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.741344
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.934453
GTEX-WYJK-1326-SM-3NB2T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25109
608_ATF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.629365
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7872
EC-GI-10	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.13121
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-74-HM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289795
POU1F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09351
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.629179
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.68551
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09685
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675164
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54396
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38729
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98792
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924004
l540	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.698
GTEX-OXRO-1226-SM-48TDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14125
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.79463
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.797446
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940065
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77422
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207927
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06384
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.63113
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559679
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18497
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.97876
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.64149
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907602
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880351
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09296
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9033
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435174
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.71465
GTEX-X4EP-0726-SM-3P5YJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18947
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82061
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839919
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.975748
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15672
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951518
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585333
GTEX-R55F-1726-SM-2TF4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04386
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.767134
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35217
Odanacatib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3359
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597631
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49087
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11821
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960628
BeWo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.512466
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.952117
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39995
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.619739
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23294
8898_THUMPD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588655
7465_RPL36A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501301
BEC	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.743759
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7614
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hodgkin lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.234
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36132
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22531
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883045
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.598307
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02111
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959103
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.866377
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562756
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897449
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594766
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PTPMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14909
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512842
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12063
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20166
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906284
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.039
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535775
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29199
TRAPPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22175
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67892
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41522
prostate	GTEx Tissue Gene Expression Profiles	1.0	1.1078
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7497_RPS10-NUDT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.59109
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269572
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44302
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910828
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456034
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10757
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527089
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551108
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13286
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.20662
ZNF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43261
GTEX-RUSQ-0126-SM-47JWV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849854
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.83306
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2127_DDX51_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.618429
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524704
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.889017
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12528
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980794
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984114
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37274
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446186
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955715
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7527
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06972
SPECC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17933
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20583
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64985
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.857039
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551586
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23272
DE-97-IV02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280746
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473933
2113_DDX24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521302
LIPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68898
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426518
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.929485
TAF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3456
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887197
MOLT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26836
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58082
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.052
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.84388
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436165
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84516
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222364
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02137
Epristeride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.955945
BMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85035
2557_EIF3M_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623606
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.91118
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42608
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960512
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894867
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.97876
ZINC8945	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505308
7443_RPL18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.863429
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95371
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14778
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27703
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950057
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64155
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.806653
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304702
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.823935
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17916
STK772817	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.80859
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17339
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.82697
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0601
MIX23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05784
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68303
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542365
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3841
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18749
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02857
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	1.0	3.01714
GTEX-NPJ8-2526-SM-2HML8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51309
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63534
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889389
GTEX-WXYG-0226-SM-3NB2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922495
Berzosertib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.39
Syncytium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910438
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0311
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10616
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922855
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89848
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24991
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.979186
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648973
7537_RPS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551956
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10757
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2127_DDX51_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528858
UF-98-OM26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421075
8791_TCOF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.575156
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949386
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580768
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8687
Hs-746T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.25692
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.559128
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58437
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEP170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04892
RABGGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65945
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11712
GTEX-NFK9-2226-SM-3MJGP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68927
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_SOX6_TrsFib_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01498
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337236
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11168
CSDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06216
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831016
HERPUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28924
VRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00662
RDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10394
RAD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45562
10703_ZNRD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674509
RET_druginhibition_184_GSE49414	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.57829
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0265
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32214
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563732
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840811
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72596
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31878
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8462_SSX2IP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570998
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6138
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.28853
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02356
5550_NDUFAF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500758
1489_CENPP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545399
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3924
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857298
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843527
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15677
GTEX-VUSG-1226-SM-4KKZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971595
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309161
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3973
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0802
RTCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46327
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46362
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.934286
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5144
9916_YAE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502943
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952514
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.95858
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547977
10738_ZWINT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.502559
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22944
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.835343
Mrsv	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.33
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304844
Gbm cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GTEX-WYBS-1926-SM-3NM8N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902765
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.828377
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349107
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02341
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34769
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13846
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46298
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66855
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54205
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHPG-0226-SM-3NMB9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951239
2102_DDX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724613
MAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20456
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3391
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.173
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37714
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14571
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.57324
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31132
9684_UTP20_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696913
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44467
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98014
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.581308
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.039
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.29966
10163_ZNF131_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.684792
2169_DFFA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539197
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8048
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63477
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12851
GTEX-UTHO-2726-SM-4JBH9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2224
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.670759
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539692
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911262
FAM86B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59314
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989333
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844179
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930221
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29403
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.981982
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00615
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.780804
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71634
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526201
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.15056
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.751941
GTEX-RWSA-2026-SM-47JX8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50179
GSE243199_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291746
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963388
GI-ME-N	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85765
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31244
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.497507
AMN 082	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563756
6261_PGM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555948
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371639
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998203
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28782
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.792297
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397318
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3579
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.856436
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597751
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274126
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.933527
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05312
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36093
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.669781
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.628027
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.703
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35332
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17031
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286913
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543117
FUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14234
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982752
L-428 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.539
GSE148010,GSE148120_3_v_2_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.644891
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.79737
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8954
TRIM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0174
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60474
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45788
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887952
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236853
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954783
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29123
AF-01-FE42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325012
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.816282
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29373
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901702
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.71417
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28905
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925739
6215_PELP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532623
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51341
AR-C155858	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
PELO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05586
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925404
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349225
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1433
GTEX-QEG5-0826-SM-2I5GF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87827
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314364
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.729406
RBMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03703
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10889
2128_DDX52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500627
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05443
5738_NOL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.83722
5733_NOL11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594308
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.783643
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.968897
PAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20662
8791_TCOF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531088
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39986
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19099
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949674
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.90461
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5396
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67289
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43351
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.955426
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
501_ARL14EP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525047
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406152
LNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23598
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
9174_TOP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604206
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-0626-SM-3MJG7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35936
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895747
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985217
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0027
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.501108
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0867
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71126
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682116
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193541_0_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.560717
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1529
AIF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07914
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64227
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40798
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19596
Choriocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406482
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06269
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903209
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61382
Retigabine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.873064
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.730767
7503_RPS15A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.619184
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13082
6574_POP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650296
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3493
Tacrolimus	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05291
MRTO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57102
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AGS	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.55838
AA-62-HP31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222893
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36069
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147240_3_v_1_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.824503
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285573
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202587
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978363
A-172 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.498
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490792
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45928
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941273
7502_RPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551347
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20046
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null