association	dataset	threshold value	standardized value
Gastrointestinal system benign neoplasm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0338
HeLa-S3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
BRD-K76518272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47169
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6387
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14831
BRD-K36170758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26746
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74803
CE-09-HG76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244207
BRD-K69466030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00343
5955_OR4K1_ENST00000285600.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676756
FN3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64767
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.65623
SUM149PT	DepMap CRISPR Gene Dependency	1.0	2.01827
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53105
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92513859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66317
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0436
BRD-K66479240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23588
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDX46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02886
MCM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.276
FANCM-MHF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.528
BRD-K36134264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78956
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62589
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358282
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1691
PML body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.198
ZBTB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27654
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0393
CRKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45215
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02503
TEN	DepMap CRISPR Gene Dependency	1.0	2.38831
BRD-K16518464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04773
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81199760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12455
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5882
GSE196699_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Debio-1347	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.8
PMC7767525__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.502726
BRD-K69668461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26029
Antiviral mechanism by IFN-stimulated genes	Reactome Pathways 2024	1.0	null
Fanconi anemia complementation group E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
BLM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.113
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.17
Holliday junction resolvase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.827
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238614
Synaptonemal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
BA-75-VA57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203953
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257124
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.334
RecQ family helicase-topoisomerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.268
MRPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53724
BRD-K54317642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01643
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
Xeroderma pigmentosum group F	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.769
IRF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4221
BRD-K53241408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9963
BRD-K95443593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18968
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fanconi anemia pathway	KEGG Pathways 2026	1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37856
KRIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06462
PMC8026967__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Agammaglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
ZDHHC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3556
BRD-K45013233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19949
nb100	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.603
ITGB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10433
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06399
BRD-K31013025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64206
BRD-K67082570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07561
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27226238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37537
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.64034
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Choanomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
Organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	3.182
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8859461__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8950345__F1	PFOCR Pathway Figure Associations 2024	1.0	null
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3498
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256537
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0754
NDUFB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80207
Urogenital ridge	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21425
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439676
PMC7767525__F1	PFOCR Pathway Figure Associations 2024	1.0	null
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212392
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.71
BRD-K68884923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27218
Intestinal benign neoplasm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
GSE229344_1_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249093
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87807408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31506
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59013
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212679
d2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8616
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217414
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.53307
BRD-K24719325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79196
BRD-K93624320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06051
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
interstrand cross-link repair	GO Biological Process Annotations 2025	1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8325
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
RBM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59076
BRD-K96898856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47374
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89436979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83683
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08076
BRD-K57516590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29935
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42127
BRD-K83708664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12655
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88206
FB-33-LI31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213157
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46582
NXT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49864
R3HCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23995
BRD-K80414383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05494
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0798
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72641
Nijmegen breakage syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
GOLM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76613
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210476_2_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.261
BRD-K53540914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45856
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.976129
BRD-K13973870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0806
BRD-K91779437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23217
BRD-K79221878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33022
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACAD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01314
BRD-K51342021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49752
Zeta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.877
PMC4865030__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K94516254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07954
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
PMC6555970-40246_2019_210_MOESM2_ESM.xlsx-DRG_LF_birds_reptiles-Gene_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24907
BRD-K22065327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89596
JA-79-II25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510721
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7721
BRD-K91593159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20921
BRD-K74382273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44311
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300393
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.979
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.178
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03814
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3598
PMC2106361__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K82056353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00197
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RPS6KA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01232
XPC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.428
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.989
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2007
GPR180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4463
CRCGN017_MCF10A.WT.HP_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16015
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04377
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3064
Origin recognition complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.884
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
chromosome, subtelomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43424
Endodeoxyribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.739
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
BRD-K71339292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66651
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295275
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96641838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21434
BRD-K62148271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27272
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.850335
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30548
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21761
BRD-K87213231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12645
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12818
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03271
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
655_ATP5F1C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560913
BRD-K65598127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09492
Cell trailing edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6154
TMED8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09729
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86025005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52813
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0072
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52504
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MutLalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.477
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
MROH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4145
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SERPINE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49886
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARPC5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19459
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SPC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20121
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37584
PMC6604281__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC10420029__F11	PFOCR Pathway Figure Associations 2024	1.0	null
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
smc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.147
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
BRD-A77697958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19763
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
N6022	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
NB6	DepMap CRISPR Gene Dependency	1.0	2.76621
BRD-K15775306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09245
CRCGN015_HEPG2_48H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1376
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.56956
GSE67266_5_v_1_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH226	DepMap CRISPR Gene Dependency	1.0	2.23853
BCAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11316
GSE211286_4_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89333198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00601
BRD-K67898193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06679
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610148
BRD-K52932858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80877
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240407
PMC1852792__F6	PFOCR Pathway Figure Associations 2024	1.0	null
PMC3678388__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.761744
RHOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21277
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.754
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87808996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29953
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.146
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42472
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K43435656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14936
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4444
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316888
MCEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.31634
Ku70:Ku80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
TAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71659
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79497053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12398
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alogliptin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
Lateral element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.98
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05261
pre-replicative complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.729
PMC4573851__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K52075209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59403
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
BRD-K36575696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11871
BRD-K11671824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06748
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7897
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUM1315MO2	DepMap CRISPR Gene Dependency	1.0	3.28532
BRD-K69248736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04417
BRD-K84794783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29758
A253	DepMap CRISPR Gene Dependency	1.0	2.64505
BRD-K50291875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52489
BRD-K67430561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54622
BRD-K90157100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11
PDRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04426
Swi5-Sfr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61687409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14857
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88836117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71945
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
PMC7821388-DataSheet_3.xlsx-MYBL2_DDR_ChIPseq_Analysis-Gene_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2715236__F6	PFOCR Pathway Figure Associations 2024	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
OTOL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85083
CHCHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5569
BRD-K65910757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22899
BRD-K69408624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29492
BRD-K74651253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59567
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584523
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
BRD-K46726368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04235
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22443456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11468
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
PNMA6F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2159
Synaptonemal structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.281
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217748
Progeroid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
RBM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42644
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Red blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.815
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38789
GSE180982_1_v_0_mlst8_human	RummaGEO Gene Perturbation Signatures	1.0	null
FANCM-MHF complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
TAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67514
BRD-K93159873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81101
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.690752
SCH 58261	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
PCI6A	DepMap CRISPR Gene Dependency	1.0	2.68205
Heart	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MKN28	DepMap CRISPR Gene Dependency	1.0	2.57178
FKBP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08932
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27578003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07349
BRD-K73500713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.859
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39062
SIGIRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71598
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33764
BRD-K25773863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00853
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.707
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37207
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08733
BRD-K35413741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24841
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267905
BRD-K79347397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00706
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.964
BRD-K80819226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06794
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18904
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216227
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62705
Trichothiodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
NHLRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20928
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A14424697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92381
CE-15-DU45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209361
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591487
BRD-K19009595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28366
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.15903
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30789
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.3062
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2245
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.56468
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1864
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10648
Cell type benign neoplasm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_6_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CTCF_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22582
BRD-K37120019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09705
BRD-K60430317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47899
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.8437
C18orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11421
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69687
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2336
BRD-K87343552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10311
KB-78-BE93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226364
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
P31FUJ	DepMap CRISPR Gene Dependency	1.0	2.53302
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402541
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.806263
1br3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
BRD-K73681382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3876
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39613696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23114
PMC3108053__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37780492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70634
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.67
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74540252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18286
BRD-K73364700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19894
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K92891227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4418
CST complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04655
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.69384
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39966
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500042
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241175
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.16383
HDMYZ	DepMap CRISPR Gene Dependency	1.0	2.13792
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.18925
Telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
PMC7244323-elife-55325-supp3.xlsx-This_paper_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43293
BRD-A14842104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01516
GSE103372_0_v_3_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	2.37288
BRD-K77518191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19333
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.786514
GADD45GIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01914
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223609,GSE223610_0_v_2_kdm6a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.989
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542074
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230705
MutLgamma complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
MEST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40076
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
PMC4123742__F7	PFOCR Pathway Figure Associations 2023	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446593
LATS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05165
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24070365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19215
UTP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08538
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fanconi anaemia nuclear complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Immune System	Reactome Pathways 2024	1.0	null
TNRC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84361
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39191
HS729	DepMap CRISPR Gene Dependency	1.0	3.02274
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOV-21G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45621617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55339
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284317
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U2OS	DepMap CRISPR Gene Dependency	1.0	2.35355
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.808035
DA-27-BW40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202654
BRD-K03308716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11052
VA-48-TW80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215171
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.402
BRD-K92927161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87231
Late recombination nodule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74978191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33953
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25669
Dinoflagellate epicone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.101
BRD-K14251637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27934
BRD-K65561930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37448
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8039
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.045
BRD-K52047843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30904
PMC11003700-pbio.3002240.s011.xlsx-MYCN-IMR32_RawData-Unnamed_2_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.751384
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE141624_3_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385283
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COV362	DepMap CRISPR Gene Dependency	1.0	2.21117
BRD-K92212152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40079
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91406875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20645
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3962
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
A549_AICAR_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167811
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3591
BRD-K25387295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40812
PMC6279925__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Fanconi anemia complementation group I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
BRD-K51054674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53916
BRD-K17840858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46389
LC-57-RH78_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223107
BRD-K40378743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03659
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08249
BRD-K08929846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00751
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Seckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.831
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323831
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K73227539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03639
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55044
BRD-K78873216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06366
JHOS4	DepMap CRISPR Gene Dependency	1.0	3.00857
GSE143643,GSE143644_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUDT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8732
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.854303
GRHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.033
CRCGN016_MCF10A.WT.HP_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14612
BRD-K33597325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47647
GTEx Blood 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-3.09313
BRD-K95153427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36585
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PPIP5K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46245
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02762
9847_WDR82_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556498
BRD-K70042405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95359
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280634
BRD-K34024207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03755
CRCGN009_HEPG2_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08264
Cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6015
PMC2715236__F6	PFOCR Pathway Figure Associations 2023	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	3.40771
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.750255
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hi-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20657
TRAPPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12555
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_DDR_Genes_NOT_HNSCCHNSCC_DDP_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.763
7471_RPL39_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.710597
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25295
BRD-K82967678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09365
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97574
BRD-K50117485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29757
Indapamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
BRD-K17956418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12574
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31309
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Serous adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
2613_EMC3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578426
MERO83	DepMap CRISPR Gene Dependency	1.0	2.01028
BRD-K64329997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83085
BRD-K70357895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06214
KE39	DepMap CRISPR Gene Dependency	1.0	3.13427
Common variable immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
NMB	DepMap CRISPR Gene Dependency	1.0	2.93282
CE-15-YU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256874
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24072
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1429
BRD-K28351377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94132
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5786
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.902855
BRD-K47200630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23272
UBC13-UEV1A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.024
BRD-K88128293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50875
PMC7553775-elife-61287-supp1.xlsx-Muller_2014_DREAM_bound_genes-Genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506669
BRD-K14163107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10727
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08406395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22814
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13257316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39663
BRD-K79997957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05768
Epstein-Barr virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.607578
Autoimmune lymphoproliferative syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
BRD-K33891642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87144
BRD-K02839126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47365
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21787
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2868
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33166
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K18176829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0531
BRD-K21841771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28725
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70118
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoproliferative syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZE-14-BN99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222407
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99226
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1611
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20682
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8332
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ORC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59256
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.836739
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.52079
CAL78	DepMap CRISPR Gene Dependency	1.0	3.2468
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-832-ENSG00000160321_ZNF208	Rummagene Transcription Factor Associations 2026	1.0	null
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72258
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7610648__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.13495
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05724
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.810651
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253851
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28543
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7774
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.494
BRD-K07928699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14616
URGCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28122
BRD-K61698250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08933
SRSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1735
BRD-K98720112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.314
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUPM2	DepMap CRISPR Gene Dependency	1.0	2.2057
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562301
SETD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.33677
GSE248045,GSE248046_0_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DNA repair complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.217
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.34372
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.31049
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204818
Condensed chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.568
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28714
JD-00-TT75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291385
Condensed nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.39
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4806
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221276
Rad6-Rad18 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.568
BRD-K75311902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12338
BRD-K84362145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2661
Leukoplakia of penis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
BRD-K97707303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23936
RAB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02947
Lynch syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
SREBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00505
PMC4390530-NIHMS667786-supplement-1.xlsx-Sheet1-Supplementary_Table_2_Genes_closest_to_AR_induced_ASH2L_peaks_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83085
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55174
BRD-K45044525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41188
BRD-K82791632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57703
BRD-K22584556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34932
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60161601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01575
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
BRD-K99807388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84166
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.728353
BRD-K76980944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12735
PMC6555970-40246_2019_210_MOESM2_ESM.xlsx-DRG_LF_fishes-Gene_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
JHOS2	DepMap CRISPR Gene Dependency	1.0	3.18642
HLA-DRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17571
DHX37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56519
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71177762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38909
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14969
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.664
STK38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83814
Ovarian serous adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14195
H3118	DepMap CRISPR Gene Dependency	1.0	3.04742
BRD-K71472853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72183
Xeroderma pigmentosum variant type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.656
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97595801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49161
Li-Fraumeni syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
NCCMPNST1C1	DepMap CRISPR Gene Dependency	1.0	2.72048
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NEIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1794
PIGW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17457
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21736
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76765
BRD-K66973998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73645
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7766
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77504251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1186
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PKN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66674
BRD-K01916633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02062
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.53457
BRD-K97393725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12599
DNA recombinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MutLbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
CLDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16414
PMC12079334-ADVS-12-2501734-s002.pdf-191-ENSG00000168813_ZNF507	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248151
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.798
Nuclear telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.29
Early recombination nodule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.779
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6879
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49181
Nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.061
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31204
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69482343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10749
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.537369
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	2.75988
NR2C2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19271
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fanconi anemia complementation group T	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3452
MYLA	DepMap CRISPR Gene Dependency	1.0	2.14686
DDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03533
Colorectal adenoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
PMC4573851__F1	PFOCR Pathway Figure Associations 2023	1.0	null
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.2686
BRD-K36643302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07486
BRD-K80424876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52674
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JMURTK2	DepMap CRISPR Gene Dependency	1.0	2.51448
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
Osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.544
MAU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0599
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52231251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27995
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36732
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.743
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28571
PMC4521181-oncsis201520x8.pdf-131-SETBP1_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85532500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08563
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46855
PTPRCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4672
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MEIOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52313
BRD-K00773626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22785
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03219
BRD-K27945483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18305
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.670597
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3707
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261117
2114_DDX27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535842
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531075
PMC4865030__F1	PFOCR Pathway Figure Associations 2023	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594579
GSE166914_1_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53-32428506-HUMAN-LIVER-HEPTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58044926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27373
PMC5858900__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K03470412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4538
KAT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32994
BRD-K26156776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15938
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RACK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92807
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2619
ATP13A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38859
BRD-K02614439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04867
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0924
AB-12-PP61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25694
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01024
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69939
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02013
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22197
BRD-K73849129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77633
PMC6433297-pbio.3000178.s012.xlsx-DREAM_targets-BUB1B_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36197756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42843
Cellular anatomical entity	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	3.182
TRIM24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68928
PMC3108053__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51498205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05378
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fanconi anemia complementation group V	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
BRD-K34721572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85538
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-58-LZ09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208217
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K94184760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0164
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.23872
BRD-K82509605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51265
PMC4865030__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K89108431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6305
BRD-K87418665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57573
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
PMC2106361__F1	PFOCR Pathway Figure Associations 2023	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.86473
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.936253
RPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23394
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.73565
STX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18251
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
TF-77-DW08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20605
BRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60949
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Adenoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.45997
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5687
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61623863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48359
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24318
BRD-K11781871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31705
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_2_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68936
BRD-K55584718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66355
BRD-K96968070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94119
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13207
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273445
X-linked lymphoproliferative syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
EEF1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18941
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.48414
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61645
Hereditary breast ovarian cancer syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95068765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61831
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.342
BRD-K35001076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13276
DNA Repair	Reactome Pathways 2024	1.0	null
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467791
BRCA1-Rad51 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
ZNF99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00658
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66272
BRD-K39715006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70933
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PPRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51199
GSE214823,GSE214824_4_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	3.182
BRD-K85659077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09757
BRD-K45628030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46554
DPPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54405
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04188
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1349_CCT5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549057
NXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11591
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.847
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12249
GEMIN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7697
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.633889
DNA repair pathways full network	WikiPathways Pathways 2024	1.0	null
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95563
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00718
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02374
DOV13	DepMap CRISPR Gene Dependency	1.0	2.40704
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.59521
BRD-K91624805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05682
RPL37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13134
BRD-K08702524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03359
g2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.196
FOXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68254
BRD-K66838288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97739
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481161
CRCGN012_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10261
CRCGN011_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3606
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ANAPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96648
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14637
BRD-K61912055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4728
BRD-K84802956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62716
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
PMC11216188-peerj-12-17616-s013.pdf-320-ZNF681_ZNF681	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3874167-supp_gkt849_Supplement_Table_S1.xls-DREAM_-_unclear_TSS_affiliation-Gene_name_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.75518
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7253
GSE135514_8_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fanconi Anemia Pathway	Reactome Pathways 2024	1.0	null
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0707
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40612
Slx1-Slx4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.815
7091_RANBP10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.691207
BRD-K85410924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12115
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7244323-elife-55325-supp3.xlsx-Noordermeer_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organ system benign neoplasm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
Rucaparib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
BRD-K11423211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42743
SEC61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53421
OSTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00893
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04192407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2113
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAPRE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57876
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Uropod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.607
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426497
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410162
BRD-K27372445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69476
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RIOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4741
Chromatin	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CF-42-OS28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247351
AB-97-BI36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261627
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
PMC3398238__F7	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03730976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87139
SLC6A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6123
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04584
ZNF774	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52865
BRD-K79318338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39648
Labial palp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
LPS853	DepMap CRISPR Gene Dependency	1.0	2.87481
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ENG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1051
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.9637
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.25
BRD-K79627231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80514
Transverse filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
SALL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35984
NAPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5844
Bloom syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.121
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63201
BRD-K64066545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73942
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354158
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548206
BRD-K78439758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06461
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:B04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06918
BRD-K82852523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25331
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.7087
BRD-K05057860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06388
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.797
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.696
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
CSE1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54766
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30375
Werner syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9649
BRD-K70379342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17799
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
BRD-K37071891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07582
BRD-K90284572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38316
PMC8626541__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17249
BRD-K48679006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07446
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.543
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301462
BRD-K93846199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22506
BRD-K81006490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07038
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2717
RHEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86248
PMC3779140__F5	PFOCR Pathway Figure Associations 2024	1.0	null
SNU13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8138
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20917
MutSalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.518
BRD-K69080049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37774
METTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38318
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100354_PCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49789
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
BRD-K98408839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39859
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.63
CRCGN015_HEPG2_48H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17997
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16266179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24812
OSC19	DepMap CRISPR Gene Dependency	1.0	2.31148
BRD-K26443253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82471
BRD-K89724519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09221
GSE71468,GSE76476_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36034
HUS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90663
BRD-K02602127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35366
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3958
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30936
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.964
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27021
BRD-K67200393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11326
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303771
PMC7778457__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3594
BRD-K51446586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00513
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9109
BRD-K71251432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93353
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
ZC3H13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13866
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
BRD-K62188824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16287
6324_PIBF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538692
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270173
BRD-K61124142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45868
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K56563145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1814
UAMC00039	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346833
BRD-K73792260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6641
JA-79-II25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353298
BRD-K84118789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.73354
TIMMDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01924
BRD-K37848780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92558
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82145108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25793
PMC6433273-pone.0214296.s009.xlsx-Table_C-S3_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_6_hours_of_LPS_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3398238__F7	PFOCR Pathway Figure Associations 2023	1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317955
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.71192
BRD-K80196706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66292
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05281
BRD-K28764680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17781
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69149
NANOGP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54514
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71544970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84634
Cetrorelix	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.68373
BRD-K64770897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50367
Hematopoietic stem cell_Bone marrow_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K41729242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01725
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.812736
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14745
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77519898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67266
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9594
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9828
U2-OS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.669
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.91
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08646
BRD-K32000549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83101
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370976
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4623
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33054
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30433551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00462
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557479
253J cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
SYS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42194
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34957967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1593
Interferon Signaling	Reactome Pathways 2024	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.13012
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350554
PMC4865030__F1	PFOCR Pathway Figure Associations 2024	1.0	null
RIMOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54441
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.969339
BRD-K24752397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1907
BRD-K48541282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0208
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71087
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	3.182
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11881
BRD-K48922193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13486
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
interstrand cross-link repair	GO Biological Process Annotations 2023	1.0	null
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC1852792__F6	PFOCR Pathway Figure Associations 2023	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303494
BRD-K75038114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33706
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210323
BRD-K86721033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51603
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-383-ZNF208_ZNF208	Rummagene Transcription Factor Associations 2026	1.0	null
UMUC11	DepMap CRISPR Gene Dependency	1.0	2.51201
BRD-K48864953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15486
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3336
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429514
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37791
ADAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34231
Pachytene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
PMC12347849-mmc1.pdf-37-ENSG00000213347_MXD3	Rummagene Transcription Factor Associations 2026	1.0	null
UV-sensitive syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HS-766T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581134
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25941
SH-4-54	DeepCoverMOA Drug Mechanisms of Action	1.0	0.19
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
TUHR4TKB	DepMap CRISPR Gene Dependency	1.0	2.53716
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Golgi apparatus	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.536601
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:I09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06625
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35676
BRD-K56661847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83095
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.38235
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.823219
Cavum septum pellucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
BRD-K02361314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70812
BRD-K88559334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55673
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Rothmund-Thomson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
BRD-K62152527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30716
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Torasemide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.6809
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GLB1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28118
BRD-K53988836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32603
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7202
PMC6604281__F1	PFOCR Pathway Figure Associations 2023	1.0	null
MutSbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.745
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.73648
ZNF595	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2207
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5861
Fanconi anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.208
PMC3348545-NIHMS263168-supplement-3.pdf-384-ZNF626_ZNF626	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73337367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57012
BRD-K96449536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30119
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14094
EW7	DepMap CRISPR Gene Dependency	1.0	3.37241
IQCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63099
SPRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52363
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46308
ERCC4-ERCC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.711
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448786
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26736
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE245407,GSE245412_0_v_1_smurf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28159131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71001
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90155857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14618
PMC9453478__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K08759542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10495
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.311
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DNA polymerase III, clamp loader complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.37
single-stranded DNA-binding protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
TYKNU	DepMap CRISPR Gene Dependency	1.0	2.50955
BRD-K56276074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07376
9521_UBE2V2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519048
Cytokine Signaling in Immune system	Reactome Pathways 2024	1.0	null
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81973
TNFRSF12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80938
RET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62166
ARHGAP21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29668
RSL24D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58768
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5166
Replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.803
Replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.021
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AP4M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21111
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255859
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4064
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309338
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.16265
BRD-K21296995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6066
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K65086352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03752
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4412
PTCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05848
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67099
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223907
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54968
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SEC14L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38426
EYA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0353
BRD-K85362541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50967
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chromosome, telomeric repeat region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.658
BRD-K95651150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23382
BRD-K89014570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07653
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5045
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41492504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40427
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73611
Fanconi anemia complementation group D1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.024
BRD-K97638135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21852
Antropyloric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
Y79	DepMap CRISPR Gene Dependency	1.0	2.6276
PMC7672319-mmc3.xlsx-DREAM_MSigDB62-FISCHER_DREAM_TARGETS_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19645475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97928
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207035
clone81	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.271
WDR45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81835
BRD-K10871135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64173
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Shelterin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
BRD-K53026281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56548
SLR23	DepMap CRISPR Gene Dependency	1.0	2.24913
BRD-K67526257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01316
Xeroderma pigmentosum group A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56797
DNA ligase III-XRCC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
BRD-K26734305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53124
GSE148066,GSE157787_9_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0654
10123_ZIC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518106
BRD-K35671498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6007
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.99767
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3768
BRD-K49042040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11406
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LY2365109	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
BRD-K02393180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92321
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A64374397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06054
BRD-K20203758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26832
FKBP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05938
BRD-K37269981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52915
HCST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16578
MutSgamma complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.228
ZNF804A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35622
BRD-K63859730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39059
BRD-K11804865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4667
BRD-K87082948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45315
BRD-K38248167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47428
Hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
BRD-K62072978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01534
BRD-K42849858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27673
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.264
DNA repair	GO Biological Process Annotations 2023	1.0	null
BRD-K88997070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83677
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PGGT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04225
BRD-K69337311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5808
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200023
BRD-K09146396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12482
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3999
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08982
AA-67-TF79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.479761
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70118
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30062
DNA-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.323
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07228
Bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.535
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486482
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04562
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.724
PMC5027689__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09056
Isoproterenol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
b95.8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
BRD-K37929710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88276
PMC11101335-41417_2024_748_MOESM1_ESM.pdf-43-ZNF569_ZNF569	Rummagene Transcription Factor Associations 2026	1.0	null
OB-61-XZ91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204338
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5502
HB1119	DepMap CRISPR Gene Dependency	1.0	3.25824
BRD-K16885048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22696
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6133
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.881117
MutS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.419
BRD-K51364219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34151
GD-73-ZF64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30728
SYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9831
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCM8-MCM9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.012
PMC3779140__F5	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K27248268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18657
AD-28-GJ71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337207
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7608
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62522
BRD-K57620855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10846
pg13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.855
PMC7244323-elife-55325-supp3.xlsx-Haapaniemi_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38446773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07812
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230907
BC-75-CK91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370876
BRD-K30799912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77921
BRD-K65320638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08744
V-79-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
nuc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
BRD-K11399565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58953
Shwachman-Diamond syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.43058
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534985
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07867
BRD-K61029307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75712
Recombination nodule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542334
Carbamazepine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70048
BRD-K65361030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10096
BRD-K61168987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03854
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CEP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94155
PMC7483256__F2	PFOCR Pathway Figure Associations 2024	1.0	null
A549_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153271
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20_vs_D1_815_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09895564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01413
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37184
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7753
PMC10796137-cc9-6-e1030-s001.pdf-115-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
HINT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80528
PMC5027689__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17528
SAOS-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27449
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25325
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535715
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CYLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61687
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.40716
BRD-K81277520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25045
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.70514
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82686
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546979
SCGB3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13466
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27335290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09562
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266489
ZNF75D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18053
PKR-mediated signaling	Reactome Pathways 2024	1.0	null
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361379
BRD-K41207293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8529
MORF4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87502
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5783
UWB1289	DepMap CRISPR Gene Dependency	1.0	3.29564
Atypical autism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.700218
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5581
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K35341092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56283
Benign neoplasm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-A71833059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10155
ENSG00000230707	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21585
Lymphoproliferative syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
HF-57-QB74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281345
SKN3	DepMap CRISPR Gene Dependency	1.0	2.50299
BRD-K10784927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09667
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.499
BRD-K83569804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33358
CSRNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38312
Diamond-Blackfan anemia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.25
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SAOS2	DepMap CRISPR Gene Dependency	1.0	2.8685
BRD-K58219783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57481
HC-38-KI38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315867
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25881
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ct96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3425
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597021
BRD-K59522787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93948
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6202
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.749
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9183
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8709
BRD-K45520793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09253
PMC5436301__F2	PFOCR Pathway Figure Associations 2024	1.0	null
NCIH2286	DepMap CRISPR Gene Dependency	1.0	2.05895
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03325
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8018
SKNMM	DepMap CRISPR Gene Dependency	1.0	2.31223
Rad51B-Rad51C-Rad51D-XRCC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.227
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205813
BRD-K43611837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43489
HC-48-BS22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202445
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNA replication factor A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.577
RASA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94826
PDCD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04088
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8358
CRCGN015_HEPG2_48H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01067
PMC10915192-ab-23-0304-Supplementary-Table-S6.pdf-11-SOX6_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17885598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6657
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30823
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05756
BRD-K32406588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32733
fleroxacin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68104
HS578T	DepMap CRISPR Gene Dependency	1.0	2.26423
CRCGN014_HEPG2_3H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75408
BRD-K58996625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24916
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16916
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20643
Antral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
BRD-K01910220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08283
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55985
PPM1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22435
Zosuquidar	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
BRD-K83562499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66419
TTC21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30677
SLC23A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41848
BRD-K44086628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1077
BRD-K48358706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44489
RB-48-AN54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255273
BRD-K29806938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02882
MMUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71986
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.37781
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385979
BRD-K83872468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10191
Xeroderma pigmentosum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.93
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214255
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.894
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDST8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LPIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.687
BRD-K80766355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02842
BRD-K45471346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95168
wi38va13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324374
B cell deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
BRD-K91796483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33833
BRD-K29264158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40828
Spinocerebellar ataxia with axonal neuropathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71699
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77082178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86272
CRCGN014_HEPG2_3H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34704
BRD-K25876174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36138
PI4KA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14342
BRD-K35230457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40596
Microphthalmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
BRD-K33016067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40541
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.826985
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00259
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rad51C-XRCC3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
1351_CCT7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591286
BRD-K52532740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26085
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.5481
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.43445
PMC7932549__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20428189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45082
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.651
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
PMC3678388__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K12340493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1799
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00642
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68869896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47082
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.705438
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70717477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21045
Nonhomologous end joining complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355857
PPP1R12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.69088
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208588
Epsilon DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
CRCGN008_HEPG2_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05725
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24733
BRD-K83090041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79912
G402	DepMap CRISPR Gene Dependency	1.0	2.47699
BRD-K13402127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75698
G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.717
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219917
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89051
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31203610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27704
PTPN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69448
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10638_ZNF789_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591614
DU145	DepMap CRISPR Gene Dependency	1.0	2.06623
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	2.50451
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.961055
PMC6555970-40246_2019_210_MOESM2_ESM.xlsx-Gene_relative_rate_R_to_LF-TREX1_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
chromosome, telomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.535
BRD-K69158240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7761
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.12099
BRD-K69259014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37358
ZFP69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77277
BRD-K82638914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19742
Cerebrooculofacioskeletal syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.786
QE-18-WG07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253373
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08988
BRD-K44027058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08404
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82815
RNA polymerase I upstream activating factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.398
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01577807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27397
BRD-K66016089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16302
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.78355
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531042
fibro-adipogenic progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
TOMM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0723
RH4	DepMap CRISPR Gene Dependency	1.0	2.96657
Telomerase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.69
GNPTG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17151
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30310320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47258
LRRC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52738
OVK18	DepMap CRISPR Gene Dependency	1.0	2.86345
PMC4123742__F7	PFOCR Pathway Figure Associations 2024	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6404
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-DREAM_target_genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
1200_KNL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594972
BRD-K10048365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23696
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B_2-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GINS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31882
BRD-K58284640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03138
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2149
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	3.182
STMN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30293
H4/H2A histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.723
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251618
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.81369
PMC5436301__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC5858900__F1	PFOCR Pathway Figure Associations 2024	1.0	null
LS513	DepMap CRISPR Gene Dependency	1.0	2.10978
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3254
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06676
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.38563
PALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56303
Karyomegalic interstitial nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
BRD-K96448434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14974
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.548823
BRD-K43326597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00098
BRD-K26767874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18747
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.719884
RFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92393
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8165
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18178
S0-EE-YRH3_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267239
CRCGN016_MCF10A.TP53.M_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2039
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0261
BRD-K14868348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08242
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340548
BRD-K43548664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67021
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123423
Olaparib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
RIDDLE syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
Checkpoint clamp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
BRD-K90163297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16026
BRD-A79884839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11861
PI4KB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24686
MV411	DepMap CRISPR Gene Dependency	1.0	2.00293
BRD-K11846531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02741
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08133
BRD-K81804676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3057
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0233
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43700313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39696
BRD-K68463857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08117
Eplerenone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
PMC6279925__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cockayne syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.82
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203631
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.745
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58876832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05058
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3909
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
BRD-K71775851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74598
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.627
BRD-K40419401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19705
BRD-K87131514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26104
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284862
BRD-K78907873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60671
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00645
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271203
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
PMC2945811__F1	PFOCR Pathway Figure Associations 2024	1.0	null
HC-63-SV27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245453
CDK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01926
BRD-K91235484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32502
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PSMD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19927
hr5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
BRD-K09460582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28097
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2971
PMC11938024-ADMA-37-2413413-s001.xlsx-Table_S1a_DE_Genes_analysis-Table_S1a_Differentailly_expressed_genes_Control_vs_NPs_treated_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Zygotene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
BRD-K64434200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42233
496100534_FWM_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38022
Revesz syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556827
BRD-K60905390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07021
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225546
CALM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06492
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16502264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33655
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5231
BRD-K79067166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73027
Pancytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
PMC8026967__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100459_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18069
PMC7932549__F2	PFOCR Pathway Figure Associations 2024	1.0	null
XY body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
BRD-K77548697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16195
PMC2945811__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K99331577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26921
BRD-K53900606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0005
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Punctate palmoplantar keratoderma type I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67344
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.339
2-iodomelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18541
PMC6555970-40246_2019_210_MOESM2_ESM.xlsx-DRG_LF_mammals-Gene_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
VAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22527
95T1000	DepMap CRISPR Gene Dependency	1.0	2.89132
Autosomal recessive cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.564
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435183
BRD-K67409155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59502
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28188
BRD-K32251128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65736
PMC7610648__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.237
BRD-K28937085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16559
BRD-K66623602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06016
BRD-K84974041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24231
BRD-K23614490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14041
Ataxia telangiectasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.635
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.535
ZCRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03706
GSE199189_1_v_0_creld2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36697652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39256
BRD-K17514980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75477
Chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11041
CAL27	DepMap CRISPR Gene Dependency	1.0	2.41853
BRD-K65959331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59557
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DNA repair	GO Biological Process Annotations 2025	1.0	null
GSE124014_0_v_1_nnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0676
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51049
BRD-K56261053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59995
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.93005
NUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79997
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
BRD-K01162126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83804
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100443_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13435
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67779
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
PSMB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19405