association	dataset	threshold value	standardized value
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.66174
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9078
CRCGN014_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13854
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-DREAM_target_genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08235
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:H20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14507
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6163
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.79071
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132408_0_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-32-RXRG_RXRG	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01945
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59182
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9746
K562_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167242
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1667
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42108
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54459
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.20345
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95421
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144455
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133555
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.16735
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOVA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00119
POLR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35935
GSE64513_0_v_1_foxd3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.67642
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SEZ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33896
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.52767
GSE241108_1_v_0_sulfasalazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68326
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6720_PRDM10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.588017
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83405
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42761
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10134
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5926
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06785
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143944_1_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6433297-pbio.3000178.s012.xlsx-DREAM_targets-BUB1B_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7378
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566128
PMC11949941-DataSheet1.pdf-44-GCM2_GCM2	Rummagene Transcription Factor Associations 2026	1.0	null
10875_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543212
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.98393
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80604
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SEPHS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02459
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.25872
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153855
CRCGN014_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27926
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530258
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151806
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7946
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01851
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7527
PMC10645393-jci-133-169200-s102.xlsx-Table_S14_AR-V_DNA-PK_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DNA Repair	Reactome Pathways 2024	1.0	null
A549_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109112
CRCGN009_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21431
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0491
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_3_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_5_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139261
CRCGN013_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04922
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23954
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44755
Cardiac Troponin-T levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3506
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215086_3_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13442
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.75686
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010466
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00564292
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27545
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61379
Resolution of D-Loop Structures	Reactome Pathways 2024	1.0	null
GSE148658_1_v_0_six6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.36758
CRCGN015_MCF10A.TP53.M_24H:N20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1908
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284545
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170499
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.84474
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54128
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145184
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7583
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4019
DNA repair	GO Biological Process Annotations 2025	1.0	null
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.267
CRCGN017_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28343
PMC8052288-mmc4.xlsx-PAF-DREAM-Lung_Poor_Survival-Unnamed_2_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4703
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.55455
CDC42EP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19656
KMT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70005
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140937
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute anterior uveitis in ankylosing spondylitis	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.622185
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1006
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219684
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9155
GSE148262,GSE150691_3_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.48138
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33868
CRCGN015_HEPG2_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87457
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7123
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.590532
UBTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17873
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.54485
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.71793
CRCGN016_MCF10A.TP53.M_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73601
CRCGN016_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03188
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF540	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92402
CRCGN014_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40134
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158506
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171341
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2585
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15352
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZDHHC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67478
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02373
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0589
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.94613
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19805
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5936
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158892
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
DMRT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5936
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7492
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DIXDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07604
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.60022
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215871
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540628
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
M Phase	Reactome Pathways 2024	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.641694
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149839
CRCGN010_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36429
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2114
K562_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0272287
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3395
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.237
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3125
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12454715-13555_2025_1471_MOESM1_ESM.pdf-119-ZNF687_ZNF687	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86116
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
EIF2B5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04947
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9193
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61487
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13913
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59783
K562_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157074
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.94968
PTDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1686
CRCGN015_HEPG2_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7327
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80102
MCF7_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0077133
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03898
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69661
IGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63573
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.3199
CRCGN014_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03951
MCF7_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177492
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140595
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134896_0_v_7_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41079
CRCGN017_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39715
1298_CCDC84_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02898
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79008
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72071
CRCGN016_MCF10A.WT.HP_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6455
PMC6459557-pbio.3000201.s012.xlsx-Sheet1-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49254
4129_INO80E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552644
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2699
TRIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19039
7524_RPS3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.711856
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02503
CRCGN008_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0979
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3469
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3961
A549_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119206
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64231
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.531163
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23766
GSE211128_3_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_2_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.77198
CNPY4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36673
CRCGN015_MCF10A.WT.HP_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21049
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1755
GTF2H5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.205
QSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00873
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28714
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60028
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.22489
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125694
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9787
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174057
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9116
RIMS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1308
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.49488
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162368
B9D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27574
PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4247
DNA Double-Strand Break Repair	Reactome Pathways 2024	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09939
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1619
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195568_2_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1564
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00978112
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17032
PMC4608010-srep15184-s1.xls-uniqGenes_UP_DN_Targets-HAN_SATB1_TARGETS_UP_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF354B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04828
K562_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166901
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123511
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155404
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10788
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20678
GSE214382,GSE214383_5_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89461
LYPLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08684
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14861
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.23182
CRCGN016_MCF10A.WT.HP_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01093
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23179
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3767
Reproduction	Reactome Pathways 2024	1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7727
CRCGN015_HEPG2_48H:I22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20963
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47785
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164179
CRCGN015_HEPG2_48H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.10343
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155681
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68655
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015031
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4146
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B_2-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5707
PMC7397849-supp_gad.338681.120_Supplemental_Table_S2.xlsx-S2B_in_vivo_shared-Suppl_Table_S2B_shared_genes_between_RCAS-YAP1-MAMLD1-dR3R1_RCAS-YAP1-FAM118B_RCAS-YAP1-TFE3_in_vivo_tumors_RCAS_mouse_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:I03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88285
CRCGN017_MCF10A.WT.HP_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01834
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.91729
CRCGN008_HEPG2_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30765
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-TPRX1_UP-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_up_to_an_FPKM_of_at_least_2_TPRX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82925
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.90695
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.889
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14804
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.982312
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12716
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22796
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Meiosis	Reactome Pathways 2024	1.0	null
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8362
GSE146982_4_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00947171
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8185
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180882
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.84981
PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6358
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1813
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42839
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99735
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8523
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66172
GSE165548_2_v_4_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1981
CRCGN017_MCF10A.TP53.M_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27225
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.54547
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.87855
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7942
CRCGN015_HEPG2_48H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22875
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.40408
Basophil percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.91549
MT-ND4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23404
APAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22077
8890_THOC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736442
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169408
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-5_Comparisons-E2F2_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0594
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1054
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53734
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-481-ENSG00000143171_RXRG	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.88952
CRCGN014_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16035
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8364
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43317
CRCGN015_MCF10A_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4256
Homology Directed Repair	Reactome Pathways 2024	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25735
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6372
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8787
GNPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18926
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12165
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46475
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6239_PFDN4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518797
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0133
PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_6_MAF_and_E2_downregulated_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9034
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8688
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158979
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138496
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04976
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20247
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2375
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8411
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164726_0_v_1_phf10_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.614033
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CTCF_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.27301
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02902
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3987
BRD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23126
Mitotic Prometaphase	Reactome Pathways 2024	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7594
SLC7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23686
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-2_E2F1-Gene_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97575
CRCGN015_HEPG2_48H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7803
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Down_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65452
GSE130401_4_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:N20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12463
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
496100537_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06114
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05944
ZNF384	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20175
K562_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213152
PMC7794364-41540_2020_161_MOESM3_ESM.xlsx-U87MG_Unique_-_PPH2_predictions-Gene_Sym_SMAD9	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.86195
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165836
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1_high-signal_selected_bound_promoters_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE181492_1_v_0_chrysin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0627
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09232
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.7666
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00898083
GSE178340_7_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Resolution of Sister Chromatid Cohesion	Reactome Pathways 2024	1.0	null
CRCGN010_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0151
A549_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136781
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65414
CRCGN015_MCF10A_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0682
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.08023
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161158
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7068
METTL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.097
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63436
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTNNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30021
USP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27105
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3657
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8204
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165518
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47725
CRCGN015_MCF10A.TP53.M_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68021
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.88382
PMC7927818-AAC.01755-20-s0002.xlsx-Supplemental_Table_1-Supplemental_Table_1_List_of_significantly_altered_genes_in_MDMs_differentiated_in_the_presence_of_PrEP_FTC_v_No_Drug_TDF_v_No_Drug_FTC_v_TDF_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72666
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.441
GSE160817_3_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3947
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013574
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.061
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.52227
CRCGN012_HEPG2_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11674
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.65815
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2645
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4242
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8008
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133261
GSE125219,GSE125221_5_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240386,GSE242143_1_v_5_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195568_6_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.46454
PMC3470785-NIHMS377161-supplement-12.pdf-421-PRDM5_PRDM5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66291
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100352
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81185
CRCGN011_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13295
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37238
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15422
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31683
MDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13754
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180982_1_v_0_mlst8_human	RummaGEO Gene Perturbation Signatures	1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10943
PWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3914
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2206
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03469
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100411_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07677
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_1_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0594
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34234
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54021
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0795
PMC9237085-41467_2022_31238_MOESM4_ESM.xlsx-Table_4_MYC_BC_signature-HGNC_symbol_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.119
CRCGN013_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01519
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Resolution of D-loop Structures through Holliday Junction Intermediates	Reactome Pathways 2024	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3573
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64205
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0698
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of kinase activity	GO Biological Process Annotations 2025	1.0	null
CRCGN014_HEPG2_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47723
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101507
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09312
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.64775
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41918
GSE188458_2_v_3_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195782
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.5303
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10119
RIPK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15559
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr1_169862549_CTCTT_C_b38	GTEx eQTL 2025	1.0	3.42015
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23164
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00087
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Monocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149838
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9817
CRCGN014_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05552
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525113
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18145
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.15955
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
KIF18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15214
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46816
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11661
CRCGN017_MCF10A.WT.HP_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23295
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF329	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25489
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_11_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.168
CRLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52615
FZR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73085
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21423
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.57035
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01835
GSE211128_9_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4091
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04639
ECH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24605
MCF7_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145054
GTF2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13037
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CPNE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60217
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59855
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Eosinophil percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.02218
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05015
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.4651
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45631
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06839
ELP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74978
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7078
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7672319-mmc3.xlsx-DREAM_MSigDB62-FISCHER_DREAM_TARGETS_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.59555
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46935
PRXL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55296
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96523
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169617_1_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016852
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8153
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.7675
MCF7_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137167
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05361
CRCGN015_MCF10A.WT.HP_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06768
MCF7_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146262
CRCGN009_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19639
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.5558
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4748
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.488
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60959
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.45844
nucleolus	GO Cellular Component Annotations 2025	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93385
NPRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20001
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
2777_EXO5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50193
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.65055
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9796
RARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36481
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8337
CRCGN015_MCF10A_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.76666
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48421
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MED26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52995
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.7357
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.05
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1731
CRCGN009_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17601
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.33641
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Meiotic recombination	Reactome Pathways 2024	1.0	null
A549_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161476
CRCGN013_HEPG2_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05872
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57302
CRCGN017_MCF10A.TP53.M_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34355
chr1_169881233_T_C_b38	GTEx eQTL 2025	1.0	1.98512
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	Reactome Pathways 2024	1.0	null
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119312
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61934
PMC8616957-41467_2021_27270_MOESM4_ESM.xlsx-Sheet1-Supplementary_Data_1_Differentially_expressed_genes_FDR_0_05_edgeR_exact_test_in_MLL-AF4_infant-ALL_vs_MLL-AF4_childhood-ALL_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4441
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75357
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16675
CRCGN015_MCF10A_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04328
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16486
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60209
ZFYVE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34998
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45132
PMC3435504-msb201237-s2.xls-Supp_Table_4c-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_4_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF211	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13517
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-5_Comparisons-FOXM1_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50778
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.77999
GSE128730_3_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214212_3_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34616
CERS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22819
CRCGN017_MCF10A.TP53.M_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48213
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10082046-41467_2023_37049_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_Genes_upregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9836
CRCGN015_HEPG2_48H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65229
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCARB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28597
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.21116
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.2127
496100345_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21137
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68907
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.03546
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22125
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1117
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1846
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3496
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25125
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.027
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1-bound_promoters_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.57413
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112202_5_v_2_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
1175_CAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524579
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7633
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04601
CRCGN016_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25175
PUS7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08744
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-5_Comparisons-E2F8_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50873
GSE126463_1_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56485
CRCGN012_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19192
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11961801-12672_2025_2262_MOESM2_ESM.xlsx-Sheet_1-WGCNA_AND_DEGs_NOT_CSGs_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
interstrand cross-link repair	GO Biological Process Annotations 2025	1.0	null
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00077
BAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54388
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein kinase binding	GO Molecular Function Annotations 2025	1.0	null
YEATS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36007
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
CEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66982
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERGIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35944
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.69655
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7026
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1277
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.606
CDC45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09278
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8242
TERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42904
ZNF491	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24396
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4614
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2949
Monocyte percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0956
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3401
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06385
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell Cycle	Reactome Pathways 2024	1.0	null
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00770695
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6208
ZNF783	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25002
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0142
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151639
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10175786-Table4.XLSX-Sheet_1-GSE9750_AND_GSE7410_AND_GSE63514_NOT_Ferrotosis_genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4997
CRCGN017_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33447
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-5_Comparisons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GOLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07372
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8762
CRCGN008_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11635
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131565_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53421
CRCGN016_MCF10A.WT.HP_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15549
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8370976-41467_2021_24932_MOESM6_ESM.xlsx-Annotation-Supplementary_Data_4_GO_and_metascape_analysis_of_the_genes_downregulated_in_U87_cells_upon_ZNF768_knockdown_ZNF768	Rummagene Transcription Factor Associations 2026	1.0	null
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DLG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33618
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69832
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41185
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SSH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27676
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.35775
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0844
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28866
496100581_TCx_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21196
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2379
IL6ST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02767
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3219
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31227
PMC12408274-DataSheet3.pdf-10-THAP2_THAP2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13526
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6023
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
HDR through Homologous Recombination (HRR)	Reactome Pathways 2024	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.813
Cell Cycle, Mitotic	Reactome Pathways 2024	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0224
CRCGN009_HEPG2_24H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11803
kinase binding	GO Molecular Function Annotations 2025	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8226
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562963
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.892
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218638
GSE207301,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFATC2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45089
PMC10534007-Table_2.xlsx-S2_overlap_MSC_down_B_V-395_common_elements_in_VM-CUB1_MSC_down_and_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6682
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60815
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.661565
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48113
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190965
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7333
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1832
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
RNFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08252
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24592
CRCGN016_MCF10A.TP53.M_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43839
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6865
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95135
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11823
GSE130401_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48102
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8851
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120266
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3648
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4158
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.63975
GSE130401_6_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1224
PSMD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2771
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NHERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07414
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.6277
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02373
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217353
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.06897
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3447
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03629
GSE210476_9_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34926
DHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73829
CRCGN015_MCF10A_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39733
MAPKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28425
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.773819
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2275
INPP5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12005
CRCGN015_HEPG2_48H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14164
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5375
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19714
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.48006
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_2_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280271
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164964
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45292
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F7_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.89623
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35002
CRCGN015_MCF10A_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.16445
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of protein phosphorylation	GO Biological Process Annotations 2025	1.0	null
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12004
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2398
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13871
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2135
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11236
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04749
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07703
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.32725
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35529
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6145
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515037
PMC4608010-srep15184-s1.xls-geneSets_HAN_SATB1_TARGETS-HAN_SATB1_TARGETS_UP_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48626
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.07183
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.36707
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5548
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4025
CRCGN010_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07635
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GDAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38578
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.08036
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9714
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89143
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12309
PMC11185845-NIHMS1996282-supplement-Table_S1.xls-TableS1_txt-Kasumi_miR130_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18208
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1991
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.27619
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04121
CRCGN015_MCF10A_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21997
TNFAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7159
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11218
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21038
CRCGN015_MCF10A_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93438
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276025
regulation of protein kinase activity	GO Biological Process Annotations 2025	1.0	null
CRCGN013_HEPG2_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06078
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6065
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7889611-41467_2021_21346_MOESM10_ESM.xlsx-High_TSA_score_correlations-Supplementary_Data_6_Genes_with_expression_that_positively_correlate_with_a_high_TSA_score_in_AIRE_and_corneocyte-like_mTECs_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71954
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.37344
PMC8052288-mmc4.xlsx-PAF_DREAM_targets_H1792-Unnamed_1_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135514_2_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112219
GSE150557_1_v_0_dnmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRIO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15943
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29808
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2426
CRCGN015_MCF10A_48H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03943
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_CVGBM-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75374
VAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02724
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3173
GSE210101,GSE210114_11_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11225427-13058_2024_1861_MOESM2_ESM.xlsx-Supplemental_Table_S4-Supp_Table_S4_AR_mediated_PGx-eQTL_genes_and_associated_with_all_GWAS_traits_from_GWAS_catalog_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98779
ATP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48925
GSE210476_2_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31525
PCDHB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04912
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89813
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00893739
CRCGN015_HEPG2_48H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.76041
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3524
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3478
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28436
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5932012-41467_2018_4180_MOESM18_ESM.xlsx-Table_19-GSEA_Gene_lists-Zuber_Myb_KD_DN_HUMAN_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11519602-41418_2024_1333_MOESM3_ESM.pdf-76-GLYR1_GLYR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130367
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TUBA1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13072
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.19102
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6471
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.16078
MTFP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06561
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null