association	dataset	threshold value	standardized value
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
LITAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78608
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K34985075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3291
SKLMS1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36677
Acute Lung Injury	CTD Gene-Disease Associations	1.0	1.09751
BRD-K72034681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9109
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
alteration	GeneRIF Biological Term Annotations	1.0	null
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Mammary Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.05573
BRD-K54198678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78561
ISTMES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81229
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891494
ENAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673125
Acute Myeloid Leukemia_LAML_TCGA-AB-2839-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myocardial Infarction	CTD Gene-Disease Associations	1.0	1.45141
MAPK1IP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81758
r9 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02669
Perturb_4494_KO_Ccr8_SRP293026	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.21342
PMC8942208__F3	PFOCR Pathway Figure Associations 2024	1.0	null
AFF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546154
GSE100464,GSE100465_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NUP54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37704
Perturb_10313_OE_hAPOL1_G2_SRP075245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.6344
BRD-K13839731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38913
Hearing Loss	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K68174511_torin-2_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.976093
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61317
IRS2_KO_GDS1219_304_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
sulfur amino acid catabolic process	GO Biological Process Annotations 2025	1.0	null
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48631
GTEX-WVLH-0226-SM-3MJG6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48157
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ZNF575	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29915
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	2.88009
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.905008
GTEX-TML8-1226-SM-32QON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12859
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24539
ZNF790	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54608
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21781
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954495
Pain	CTD Gene-Disease Associations	1.0	2.01227
SPRY4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77503
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.862603
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52925
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87791
SON_KD_GDS4448_35_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K74948793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50049
CERKL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674804
Perturb_227_KO_Pet1_SRP194283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.2059
WIL2-NS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59505
hsa-miR-29b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77889
BRD-K39131701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.74195
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG7-1726-SM-4LVME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994715
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51336
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8818
BRD-K71221636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07469
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypocalcemia	CTD Gene-Disease Associations	1.0	1.01625
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66508
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.911261
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
MDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05495
KPNSI9S	CCLE Cell Line Gene CNV Profiles	1.0	1.38554
DENR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580445
Root hair tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.551
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.27409
renal	GAD High Level Gene-Disease Associations	1.0	0.293278
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.14668
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
PHF8-20622853-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K08881846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90799
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Kidney Chromophobe_KICH_TCGA-KN-8435-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10319_KO_Pdk2_SRP216037	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SLR25	CCLE Cell Line Gene CNV Profiles	1.0	1.71527
ASCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00460276
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SMARCA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488324
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
FUT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739021
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-2.03825
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parabrachial nucleus, medial division, medial medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15426
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
CLOCK-20551151-293T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE169571_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954495
SUZ12	ENCODE Transcription Factor Targets	1.0	null
LMTK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524039
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41601
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
chr1_171263074_G_T_b38	GTEx eQTL 2025	1.0	1.76547
Perturb_11747_KO_Mek2_SRP321493	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.41273
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IQGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46925
HUH7	CCLE Cell Line Gene Expression Profiles	1.0	1.74997
ERCC6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24832
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06845
JAR	DepMap CRISPR Gene Dependency	1.0	2.30622
NR1H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.65388
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01798544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10497
GSE169155_3_v_7_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94999
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
FAM234B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13901
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94116
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.778155
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77320034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56568
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO Molecular Function Annotations 2015	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Granum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.701
FEV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11824
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Microcephaly	CTD Gene-Disease Associations	1.0	1.10211
CLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502684
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.008503
PYGO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635852
BRD-K47631316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85767
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Vasculitis	CTD Gene-Disease Associations	1.0	1.03678
AZIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539657
primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.16072
BRD-K14316227_7879083_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A20731954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12102
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59309
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
liver	GeneRIF Biological Term Annotations	1.0	null
RXFP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571287
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
most	GeneRIF Biological Term Annotations	1.0	null
CPLX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591259
Pollen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.148
Bradycardia	CTD Gene-Disease Associations	1.0	1.13347
GTEX-OXRP-0226-SM-3NB14	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837942
BRD-K16843478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55413
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MOB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56753
mantle zone of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06533
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.82905
anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61317
BRD-K60353472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27071
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34885
Perturb_2893_KO_Nfia_SRP077282	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.08679
NOCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07674
BRD-K73540839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43892
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_13658_Mut_HMGN1_SRP164924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.6363
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
Metapathway biotransformation Phase I and II	WikiPathways Pathways 2024	1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.08783
related	GeneRIF Biological Term Annotations	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
LAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92463
NF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73419
ZNF222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36253
mainly	GeneRIF Biological Term Annotations	1.0	null
Gastrointestinal Diseases	CTD Gene-Disease Associations	1.0	1.71009
WDR73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26411
Perturb_4164_KO_Erbb4_SRP373176	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.70662
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19354
denatonium benzoate-3123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLOCK-20551151-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DGKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535244
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4195
ARHGAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89471
reproduction	GAD High Level Gene-Disease Associations	1.0	0.293278
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76842
GTEX-T6MO-0126-SM-4DM6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21332
BRD-K77953978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1329
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WYVS-1726-SM-3NMAY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75356
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PILRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00830029
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21667
PPARD_KO_GDS4320_619_mouse_Pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_12108_KD_CCND1_SRP244245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.1777
GTEX-WXYG-2026-SM-4E3IY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13079
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0969
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19031
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GUCY2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626462
Hyperglycemia	CTD Gene-Disease Associations	1.0	2.00015
BRD-K77490065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29303
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SPTBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058926
18285497-tableS1	GeneSigDB Published Gene Signatures	1.0	null
UBE3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17353
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
MAP3K19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00797695
BRD-K59207957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01254
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.8306
NADPH oxidation	GO Biological Process Annotations 2025	1.0	null
ZNF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18285
GAMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53814
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
15793299-TableC	GeneSigDB Published Gene Signatures	1.0	null
NFATC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00397751
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97663
MRTFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704265
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
BRINP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23236
LPGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89341
Kidney	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Breast Cancer_Mammary Gland Tissue_GSE1872	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.20717
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Anemia, Aplastic	CTD Gene-Disease Associations	1.0	1.3682
dependence	GeneRIF Biological Term Annotations	1.0	null
RDES	DepMap CRISPR Gene Dependency	1.0	4.36454
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6812-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3758
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04627
CDK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00481569
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877449
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90495
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03688
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NE-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QTRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68314
Prostate adenocarcinoma_PRAD_TCGA-EJ-5518-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69744558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12272
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.831534
FUT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00813042
TMIGD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594796
PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33916
ZNF572	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23744
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.07623
U031	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50143
GTEX-PLZ4-1326-SM-2S1O7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K62967214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13279
Weight Gain	CTD Gene-Disease Associations	1.0	2.14161
SLC19A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525198
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05589
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCIH716	DepMap CRISPR Gene Dependency	1.0	2.31472
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A61P-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A11130173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02029
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	Reactome Pathways 2014	1.0	null
Biological oxidations	Reactome Pathways 2024	1.0	null
BRD-K98089885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14422
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30356
SYDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02221
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77079
Type 2 diabetes (age of onset)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
C8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636709
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.499
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SE5C-0926-SM-4BRUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05924
CDY2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01231
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.159
mediated	GeneRIF Biological Term Annotations	1.0	null
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.186087
GSE183251_7_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAPRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2612
HMGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34255
BRD-K77908580_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3792_KD_MYC_SRP057613	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.63395
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_1677_KO_Jak3_SRP287984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
KCTD12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586679
ACOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31999
Perturb_13524_KD_Brd9_SRP333303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.6383
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18984
Endodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
SPIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91915
NCIH841	DepMap CRISPR Gene Dependency	1.0	2.49447
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19031
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89613
ZNF619	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05471
BRD-K65904652_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K55606442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9956
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.74777
BRD-K73582217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67379
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.06418
TNNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52374
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29W-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Weight Loss	CTD Gene-Disease Associations	1.0	2.15095
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	Reactome Pathways 2014	1.0	null
hsa-miR-512-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
loss	GeneRIF Biological Term Annotations	1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K82662168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24693
CLDN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0110077
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868969
BRD-K59045095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.16104
496100660_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18968
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68751
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06231
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84041
ACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32837
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50691
Cerebellar Diseases	CTD Gene-Disease Associations	1.0	1.21791
Perturb_7494_KD_DICER1_SRP186271	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.7115
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02657
GOSR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRL-0626-SM-3NM9C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91104
LATS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645511
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2273
DHX40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0255
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9475
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
sirolimus_rattus norvegicus_gpl1355_gse19366	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K19220233_JNK-9L_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23481525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35174
OGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61438
CCDC92B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50248
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40834
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
intermediate (interpositus) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59705
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2962
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
Nucleus of the solitary tract, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23111
pioglitazone_mus musculus_gpl2897_gse8806	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07651
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3499080__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.453
INHBE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72965
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POSTN_01_293	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.69936
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26539
PRR14L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462209
Perturb_15393_KD_CHKA_SRP050331	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.11434
ALVA31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.16415
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SP-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15968_KO_Gata3_SRP357829	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K83895653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34632
GTEX-X4EO-2926-SM-4E3JH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30197
FEZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73834
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47901
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22058
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-XXEK-1626-SM-4BRUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11304
GTEX-SN8G-0226-SM-4DM6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11579
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15706
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A84481105_thioridazine_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899687
Hair medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
BRD-K24671931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59035
Plasma membrane light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.815
GDM1	CCLE Cell Line Gene Expression Profiles	1.0	1.45098
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22322
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1075
OPM1	CCLE Cell Line Gene CNV Profiles	1.0	1.49554
sunitinib_rattus norvegicus_gpl1355_gds3109	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
BRD-K88597074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34108
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11561
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58901
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8572
Pancreatic adenocarcinoma_PAAD_TCGA-YH-A8SY-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68974
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6946
BT-474	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00979
NCIH441	DepMap CRISPR Gene Dependency	1.0	3.12548
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
variation	GeneRIF Biological Term Annotations	1.0	null
Catalytic cycle of mammalian flavin containing monooxygenases FMOs 	WikiPathways Pathways 2024	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EFEMP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686227
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953965
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.64822
Water	HMDB Metabolites of Enzymes	1.0	null
CKS1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589335
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RIOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4741
MAPKAPK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6722
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13967
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9848
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15106
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
CTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60521
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.06483
thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Stroke	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1897	CCLE Cell Line Gene CNV Profiles	1.0	2.09206
FASN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00393668
POR_DELETION_GDS1093_240_mouse_Liver from male 3 month old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MOLP8	CCLE Cell Line Gene CNV Profiles	1.0	1.58668
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.925907
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.32765
BRD-K50891186_GR 103691_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rheaume et al.Nat Commun.2_Retina_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
RPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02867
STK39	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624726
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0702
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56411643_-666_SKMEL1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Male inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68592
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12876
BAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95795
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15106
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24108193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5919
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6518
FECH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626515
TINAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25456
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47681
TAL1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33403
r8 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42609
BRD-K90475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2912
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83935370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51971
MYF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06452
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Defective FMO3 causes Trimethylaminuria (TMAU)	Reactome Pathways 2014	1.0	null
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852019
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
PTDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9319
PCCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44838
NCBP2AS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5464
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824782
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.69129
z85	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62491
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.976093
GSE175920_0_v_1_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PKBalpha_KO_GDS1784_194_mouse_Embryonic fibroblasts (MEFs) - 2h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A35511923_L-803,087 trifluoroacetate_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE200352_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ4-1626-SM-3P618	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16601
BRD-K97276563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06756
SST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513355
Systemic scleroderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
Lung adenocarcinoma_LUAD_TCGA-50-5946-02A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44594
Photosystem II oxygen evolving complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.34739
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.971947
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	1.06999
EVI5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49461
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4384
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE88819_6_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IRS4_KO_GDS1219_306_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KCNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547826
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11538
GTEX-XLM4-1026-SM-4AT51	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935759
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.55908
YOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87353
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_5448_OE_Vegfa_ERP109687	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.8207
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MALSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77489
COV318	DepMap CRISPR Gene Dependency	1.0	2.56995
NFATC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407319
OLANZAPINE	DGIdb Drug Targets 2026	1.0	0.518941
Prostate adenocarcinoma_PRAD_TCGA-CH-5739-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JK-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32522654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51821
Pollen wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838833
FMR1_KD_GDS4759_333_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K08996393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23484
Familial thyroid dyshormonogenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41656
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
N,N-Dimethylaniline	HMDB Metabolites of Enzymes	1.0	null
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.73319
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834803
nicotine	GeneRIF Biological Term Annotations	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
BRD-K64763803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30151
CRCGN016_MCF10A.TP53.M_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00427
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41519
GOS3	CCLE Cell Line Gene Expression Profiles	1.0	1.67721
MYBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79108
BRD-K55815187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0869
LTBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51711
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918852
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.01252
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Stoma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.11052
GSE113106_3_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18416
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NCIH1666	DepMap CRISPR Gene Dependency	1.0	2.81559
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46288
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.084741
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.44181
Adenoma	CTD Gene-Disease Associations	1.0	1.28333
496100486_PCx_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.0165
CASP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702017
HMG20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91977
BRD-K39773004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52181
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.978907
UBE2L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045198
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2614
PCTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563518
GSE191138_2_v_4_fmo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4125180__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01713
Acute Myeloid Leukemia_LAML_TCGA-AB-2867-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sulfur amino acid metabolic process	GO Biological Process Annotations 2023	1.0	null
CAOV4	CCLE Cell Line Gene CNV Profiles	1.0	2.87041
Encephalomyelitis, Autoimmune, Experimental	CTD Gene-Disease Associations	1.0	1.20295
TXNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36776
GSE226397_0_v_1_cystine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32608
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.25525
BRD-K92571446_WZ-3105_MCF7_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.73536
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10464
TE-441-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.76405
GSE180525,GSE180528_2_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29802952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00656
PFKL_OE_GDS4410_75_human_Biceps muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KYSE410	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45979
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Precancerous Conditions	CTD Gene-Disease Associations	1.0	2.02641
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.921312
Cardiomyopathy, Hypertrophic	CTD Gene-Disease Associations	1.0	1.16236
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Phosphomannomutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.004
Mammary Neoplasms, Animal	CTD Gene-Disease Associations	1.0	1.30881
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
TE4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83857
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
LU65	DepMap CRISPR Gene Dependency	1.0	2.99155
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.46712
Consciousness Disorders	CTD Gene-Disease Associations	1.0	1.33375
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.078
Ischemia	CTD Gene-Disease Associations	1.0	1.19014
Cerebrovascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80999
Pruritus	CTD Gene-Disease Associations	1.0	1.59849
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2015	1.0	null
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03497
GGT7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00797021
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23592
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Thrombophilia	HuGE Navigator Gene-Phenotype Associations	1.0	null
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K16554956_PTB1_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3125	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07916
CBX6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00428882
BRD-A19500257_geldanamycin_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-24	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73B-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brn3a_KO_GDS1651_248_mouse_Embryonic (day 13.5) trigeminal ganglia - homozygous	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_13742_KO_Nfib_SRP096738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.64455
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYBS-0626-SM-3NMAS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16068
TUHR4TKB	DepMap CRISPR Gene Dependency	1.0	2.37933
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77051
Perturb_3914_KD_CTNNB1_DRP003300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.63803
TMBIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605259
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
SUDHL4	CCLE Cell Line Gene Expression Profiles	1.0	1.5736
Perturb_12080_KO_Ezh2/Stat5_SRP060232	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.3334
BT474	CCLE Cell Line Gene CNV Profiles	1.0	1.55263
ZNF708	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64904
cell part	GO Cellular Component Annotations 2015	1.0	null
Artery disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.60272
BRD-K40206099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17369
IL4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79493
ALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55622
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4599
hsa-miR-1251	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Perturb_8500_OE_RAS_SRP150620	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.1879
BRD-K73145196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20851
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4446
BRD-A75409952_wortmannin_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD302	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487553
ARL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33745
Perturb_6839_KO_EIF5A_SRP199981	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.51963
Voriconazole	DrugBank Drug Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A83P-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Flavin monooxygenase-like	InterPro Predicted Protein Domain Annotations	1.0	null
16151515-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_15563_OE_TLR3_SRP341542	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.57494
GTEX-X585-1026-SM-46MW6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07448
GSE160373_5_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99672
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
taurine metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K90697693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19956
nucleus subcoeruleus, r1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74404
Lethargy	CTD Gene-Disease Associations	1.0	1.04574
GTEX-QDVN-0426-SM-48TZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06715
Root quiescent center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11301
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94401
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EB2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T5JW-0326-SM-4DM6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30873
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39123
MMP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18616
t70-white-adipose_male_1w	MoTrPAC Rat Endurance Exercise Training	1.0	1.31929
CD180	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554036
PMC6469946-aav1472_Data_file_S3.xlsx-PPARG_targets_UP_RNA-Seq_Diet-Supplemental_Table_3_PPARG_targets_up_regulated_in_dKO_vs_CONTROL_RNA-Seq_Diet_FDR_0_1_n_290_PPARG	Rummagene Transcription Factor Associations 2026	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39483
KLRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628623
BRD-A04618830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0226
CBX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466274
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159445
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9786
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.0345
endoplasmic reticulum lumen	GO Cellular Component Annotations 2025	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
OLIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23616
Adult liver stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
other	GAD High Level Gene-Disease Associations	1.0	0.293278
Premature ejaculation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.803
Stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.42
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
PC3	CCLE Cell Line Gene CNV Profiles	1.0	1.45464
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23959
GTEX-PLZ4-0226-SM-2S1NW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914469
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27435
Perturb_9258_KO_Mr1_ERP107271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.59914
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40408
GOT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646388
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.2937
endoplasmic reticulum part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-VP-A87C-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30218
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11137
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514644
r7 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39254
Drug Eruptions	CTD Gene-Disease Associations	1.0	1.21951
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.41884
pulmonary edema	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.771661
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
mantle zone of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03871
BRD-K61520618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0601
sod1	GeneRIF Biological Term Annotations	1.0	null
IL17RE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563184
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BZ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p2 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11026
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K19507340_Megestrol acetate_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
QKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594894
variants	GeneRIF Biological Term Annotations	1.0	null
BRD-K50140147_S1108_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP63_01_196	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.34351
GTEX-TKQ2-1826-SM-33HB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875218
Blindness	CTD Gene-Disease Associations	1.0	1.01212
BRD-K73261812_-666_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRPM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609573
t30-blood-rna_female_2w	MoTrPAC Rat Endurance Exercise Training	-1.0	-17.8956
PMC10202654-mmc3.xlsx-MSC_markers-COMMON_MSC_MARKERS_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5403
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11712
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00626
BRD-K75081836_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R53T-1526-SM-48FEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931223
IL23R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600749
BRD-K51575138_TPCA-1_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Jaundice, Obstructive	CTD Gene-Disease Associations	1.0	1.48633
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19031
HCC-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cholestasis, Intrahepatic	CTD Gene-Disease Associations	1.0	1.86907
SBK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21598
Locus ceruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58165
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18392
TOP2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631276
Erep	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.794
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cholestasis	CTD Gene-Disease Associations	1.0	2.08344
16611858-FLUSetTable	GeneSigDB Published Gene Signatures	1.0	null
BRD-K95152807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30298
BRD-K70057550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10139
Perturb_11255_KO_Nr5a2_SRP131036	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.47454
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
Anemia	CTD Gene-Disease Associations	1.0	1.51657
17952122-GeneList	GeneSigDB Published Gene Signatures	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Liver Failure	CTD Gene-Disease Associations	1.0	1.90076
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99104
KATOIII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931437
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
YY2_KD_GDS3788_490_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8219
GSE239457_1_v_0_rasa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.984219
CUX1	ChEA Transcription Factor Targets	1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04992
17970077-Table5	GeneSigDB Published Gene Signatures	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03726
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31815
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC3665348__F8	PFOCR Pathway Figure Associations 2024	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.9584
ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
OTC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525435
Trimethylaminuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.34
r8 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06836
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18116
BRD-K30145193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2854
SLC23A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79878
intermediate stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02669
TMEM209	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1705
RELT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00764318
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73F-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLT4	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.977086
Mesophyll cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.776
document	GeneRIF Biological Term Annotations	1.0	null
GTEX-XV7Q-0626-SM-4BRV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84443
BICR18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37857
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.83775
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	1.00766
hsa-miR-767-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MMP13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00337963
response to lipid	GO Biological Process Annotations 2015	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.979134
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K10684867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60386
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42931
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.219
GSE169155_3_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
sulfur amino acid metabolic process	GO Biological Process Annotations 2025	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
GSE143316_0_v_6_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PrPC_KO_GDS4352_359_mouse_Developing hippocampus from adults (3-mo-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Muscle Weakness	CTD Gene-Disease Associations	1.0	1.49148
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72785
Perturb_11579_KO_QPC_SRP166848	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-18.2757
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
DMTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97516
PRKAR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504105
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07956
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48694
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03815
BRD-K72484719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37974
GTEX-VUSG-2326-SM-4KL1U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966687
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.28814
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K13417398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01098
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
NDUFAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27963
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6966
15895078-Table2	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Neutropenia	CTD Gene-Disease Associations	1.0	1.17034
IOMMLEE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51742
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SACS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94904
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.898
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.67549
NB17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ACTR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02221
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	Reactome Pathways 2014	1.0	null
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BUB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62777
TPM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74428
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040589
GTEX-Q2AG-0326-SM-48U1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.349
tissue	GeneRIF Biological Term Annotations	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TRPC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00755883
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA10	CCLE Cell Line Gene Expression Profiles	1.0	1.4896
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8219
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5863
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K72936860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5857
Succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838421
CYB5D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00888849
Medullary reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1318
GTEX-W5X1-2626-SM-4LMI8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50095
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
early	GeneRIF Biological Term Annotations	1.0	null
GSE129811_5_v_0_niacin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92825
BRD-K21409337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33815
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
TP53BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36172
BRD-U86922168_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88903
ATF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11884
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE148692,GSE148695_1_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K17065706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06608
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25669
IRF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1051
mRNA_OTX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ADPGK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662702
PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_1_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
PPP1R35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82052
GSE186065_0_v_1_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX2-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K02708799_GSK-1059615_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K35098144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30098
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NACAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85549
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43411
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
NSUN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64496
Spinal nucleus of the trigeminal, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05877
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NTF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69082
NCIH526	DepMap CRISPR Gene Dependency	1.0	2.69533
linked	GeneRIF Biological Term Annotations	1.0	null
Perturb_8045_KD_ST18_SRP062868	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.97693
MAPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00414759
inner SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.867573
Pancreatitis	CTD Gene-Disease Associations	1.0	1.68062
APP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00290456
BRD-K25485483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43139
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37619
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37661
JHH2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93493
CA46	CCLE Cell Line Gene Expression Profiles	1.0	1.54572
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NOX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607465
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.90229
Root apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
Apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
Plant stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.786052
CDKN2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00779858
BRD-K20026212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.20504
NADPH oxidation	GO Biological Process Annotations 2023	1.0	null
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.34869
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
absent	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864392
PMC12178937-mmc6.xlsx-L_MAFF_KDvsL_C_deg_all-gene_id_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
TOP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.539
SLC22A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8467
pathological	GeneRIF Biological Term Annotations	1.0	null
GSE169155_3_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIM21	Hub Proteins Protein-Protein Interactions	1.0	null
Lung-mesothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.128974
LN215	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72617
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538688
CEBPE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00741645
GTEX-NFK9-1026-SM-2HMK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14635
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.5675
Perturb_8409_KO_Yap1/Wwtr1_SRP143461	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.85092
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HS-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9765
BRD-K52017042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59685
esculin-3052	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23199
mantle zone of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25188
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
Spinal nucleus of the trigeminal, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19478
BRD-K44100512_KIN001-043_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHOS4	DepMap CRISPR Gene Dependency	1.0	2.03965
BRD-K70183558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26609
GPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64885
Heart Diseases	CTD Gene-Disease Associations	1.0	1.99135
HEATR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529848
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.63721
Hydronephrosis	CTD Gene-Disease Associations	1.0	1.052
PLA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570261
Prostatic Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
SKMEL31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97762
CRCGN017_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8484
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.57688
HCC95	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4763
GSE96991,GSE97117_3_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ6-0426-SM-2I5FG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840143
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42F-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8513
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01819
TRIM28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684931
Perturb_10280_KO_Mid1ip1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.0358
GAB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547184
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SNU182	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75373
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864049
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NADP	CTD Gene-Chemical Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19W-06A-41R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Integrin alpha10-beta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
implicate	GeneRIF Biological Term Annotations	1.0	null
BRD-K28296557_Akt inhibitor IV_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
tightly	GeneRIF Biological Term Annotations	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	2.39394
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A23345137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15485
BRD-K83846772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51587
RXRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69695
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42822
Keloid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.199
GPR183	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00771367
BRD-K78866630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40129
Tamoxifen N-oxide	HMDB Metabolites of Enzymes	1.0	null
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Auxin efflux carrier complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
KDM5A	ENCODE Transcription Factor Targets	1.0	null
Perturb_15543_KD_Map3k7/Chd1_SRP201304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
HOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05563
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8843
Ventricular Fibrillation	CTD Gene-Disease Associations	1.0	1.27533
TAMOXIFEN	DGIdb Drug Targets 2026	1.0	0.76713
PRRT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46675
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Eccrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.71
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.62036
C5orf24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89222
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58825
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CDH24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86187
17875932-Table5	GeneSigDB Published Gene Signatures	1.0	null
gill	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248683
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.334
first	GeneRIF Biological Term Annotations	1.0	null
ASIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0026
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.9064
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36503
Acute Myeloid Leukemia_LAML_TCGA-AB-2863-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32392
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANTXR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00800179
IER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59873
CAL148	CCLE Cell Line Gene CNV Profiles	1.0	1.53163
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19756
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3468
BRD-K73478880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05737
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.3058
INCENP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691958
TNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608843
TLR10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535173
HFE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00487
Lower epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.66809
Nicotine Dependence	DisGeNET Gene-Disease Associations	1.0	null
CKAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18241
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30417
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
PHGDH_KO_GDS2874_125_mouse_embryonic head tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859075
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879319
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53857
XRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.86358
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11712
Leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.391
Perturb_11403_KD_CPT1A_SRP076884	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.8916
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.04687
KMS-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71159
Obesity	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64544
GTEX-X15G-1626-SM-3NMB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1412
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47806
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYO3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632654
BRD-K76742876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2664
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72419
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81726
nadp binding	GO Molecular Function Annotations 2015	1.0	null
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12435
SCN4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666247
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Forearm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2C2_02_77	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.6477
BRD-K03599766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1921
HEC59	DepMap CRISPR Gene Dependency	1.0	2.32119
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MARCHF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1057
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Merocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
BRD-K10775155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16954
LS1034	DepMap CRISPR Gene Dependency	1.0	3.6373
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2897
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14761
GSE160373_1_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228125_0_v_3_ptafr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.605709
isthmic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04601
DYNC2I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55305
CDK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649362
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.399
pontine raphe nucleus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.56555
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K42145213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11836
MDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10535
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.08783
PMC9204954__F2	PFOCR Pathway Figure Associations 2024	1.0	null
E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_5707_KO_Abcc8_ERP119268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
VPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47563
BRD-K02241673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83477
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.16084
BRD-K51844455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19697
Catalytic cycle of mammalian FMOs(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15141
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954495
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4G_HNF4G	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31143
OVMANA	DepMap CRISPR Gene Dependency	1.0	2.30605
Abdominal Pain	CTD Gene-Disease Associations	1.0	1.19835
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26225
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19228
BRD-A01717111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.2407
RELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6076
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1734
GIGYF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41535
Perturb_10927_KO_Mettl3_SRP363782	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.71749
cyp3a4	GeneRIF Biological Term Annotations	1.0	null
SOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64977
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CALB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39675
N-methyl-4-aminophenol	CTD Gene-Chemical Interactions	1.0	null
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85765
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K10923439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47942
BRD-K60474245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44426
BRD-K29975122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03173
NCI-H1048	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.926919
Sarcoma_SARC_TCGA-DX-A8BS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.941
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-58-A46L-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
SPTLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70369
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69723
Cerebral arterial disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.4633
fetus	GeneRIF Biological Term Annotations	1.0	null
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893585
colon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
examples	GeneRIF Biological Term Annotations	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
CXCR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053976
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)	Reactome Pathways 2014	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83761
PMC4698384__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Rheumatic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878683
Hypertension	CTD Gene-Disease Associations	1.0	1.9717
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
C2CD2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51731
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11581
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575715
TPRG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21875
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rosette	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.219
BRD-K61753872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68916
Perturb_17409_KO_Kat7_SRP346204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.92111
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8989
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EDS1 disease-resistance complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.172
TBC1D15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52284
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03156
LN382	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12902
ZIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01984
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Abnormalities, Multiple	CTD Gene-Disease Associations	1.0	1.14166
ELAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61482
Perturb_5695_KO_Tug1_SRP176442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.85546
cofactor metabolic process	GO Biological Process Annotations 2015	1.0	null
TMED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20703
ZNF548	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24361
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44491
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6658
PLCB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482861
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41512
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.940451
chr1_171372697_A_G_b38	GTEx eQTL 2025	1.0	1.03582
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
SLC24A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618659
vitamin c_mus musculus_gpl6246_gse19377	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
salivary gland	HPA Tissue Protein Expression Profiles	1.0	0.996274
BRD-K37790543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47084
BCL2L10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84519
BRD-K56761719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57036
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856808
DUSP26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6928
mediodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07321
QPCT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547544
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.81
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5145
RILP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11794
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZM-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H6PD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625219
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4455
hsa-miR-3192	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
EP300-20729851-FORBRAIN_MIDBRAIN_LIMB_HEART-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78691
alkanesulfonate biosynthetic process	GO Biological Process Annotations 2025	1.0	null
BRD-K43389698_BMS-387032_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4141
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38033
Splenomegaly	CTD Gene-Disease Associations	1.0	1.03789
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057987
RSL1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496145
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Coma	CTD Gene-Disease Associations	1.0	1.52287
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.20728
ZDHHC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98873
HNE-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
NADP+	MW Enzyme Metabolite Associations	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Immune system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SYCE1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16282
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.64771
BRD-K80851151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40275
BOKU	DepMap CRISPR Gene Dependency	1.0	2.12978
BRD-K58985886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62123
G361	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64172
Lung squamous cell carcinoma_LUSC_TCGA-66-2781-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nuclear envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.190175
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078628
JM1	CCLE Cell Line Gene CNV Profiles	1.0	1.33154
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Puberty, Precocious	HuGE Navigator Gene-Phenotype Associations	1.0	null
ATP1A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638822
NCIH2009	DepMap CRISPR Gene Dependency	1.0	2.01953
CACNG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00730928
LYZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00371584
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04507
TMEM266	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634956
mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.38111
DAUDI	CCLE Cell Line Gene Expression Profiles	1.0	2.65491
BRD-K51290057_Ch 55_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14608
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02365
SUCLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65753
CHIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540423
Tachycardia, Ventricular	CTD Gene-Disease Associations	1.0	1.35299
ENTPD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070415
SPOUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38274
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871819
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6968
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02676
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056733
GNA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70579
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920303
PROZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00422312
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4141
BRD-K12539581_NOCODAZOLE_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49192
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	0.895183
titanium dioxide_mus musculus_gpl1261_pregnant_gds2878	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
susceptibility	GeneRIF Biological Term Annotations	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055039
PCDH18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79598
SEMA3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56923
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040406
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUCLG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570039
TK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HMCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524772
ZFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93053
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.51506
metabolism	GeneRIF Biological Term Annotations	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K19315592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18137
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832299
TBC1D20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04308
Hypospadias	CTD Gene-Disease Associations	1.0	1.29287
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840255
ASH1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0042678
MAMSTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489818
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890531
heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
STAT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22646
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.88425
CDCP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0095758
Perturb_18120_KO_Tfap2b_SRP196877	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38825
chr1_171256895_T_C_b38	GTEx eQTL 2025	1.0	2.33864
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.53289
CDK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535145
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50098
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SEPSECS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596272
RIOK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635425
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6621
B9D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663052
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Arrector pili muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.246
BRD-K94801143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18514
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-29c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
RAX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12917
AIF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622559
CDC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441698
GSE221004_3_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QRICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27235
BTN3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7059
Seizures	CTD Gene-Disease Associations	1.0	1.97757
t30-blood-rna_male_4w	MoTrPAC Rat Endurance Exercise Training	-1.0	-4.60757
MTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37415
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84935903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.93283
BRD-K28733696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4083
DDX19A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81524
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K45519638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04085
Perturb_13506_KD_Rrp1b_SRP013709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.4515
Sodium Chloride	CTD Gene-Chemical Interactions	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27417
18497862-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Delirium	CTD Gene-Disease Associations	1.0	1.24781
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K71253424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90423
19605494-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_5503_OE_Hras_SRP026484	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PLXND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22114
hypotaurine monooxygenase activity	GO Molecular Function Annotations 2025	1.0	null
PMC11178536-jci-134-173702-s125.pdf-2-SOX2_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51270604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04974
BRD-K71935468_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040563
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08726
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K52551495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06149
PMC5097440-12864_2016_3198_MOESM4_ESM.xlsx-Adipose_ind-INDEPENDENT_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
HP-163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10927
where	GeneRIF Biological Term Annotations	1.0	null
TDRD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80837
FCRLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650172
SNRPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23243
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07812
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.75558
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
mantle zone of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08804
EDA2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54459
periventricular stratum of r1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.157
PKBalpha_KO_GDS1784_195_mouse_Embryonic fibroblasts (MEFs) - 6h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
restricted	GeneRIF Biological Term Annotations	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.954495
NPC1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725836
CDK17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692429
NDUFB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500506
GTEX-PX3G-0526-SM-2I3EM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928556
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
t58-heart_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.03447
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07872
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41771
LST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682239
WM88	DepMap CRISPR Gene Dependency	1.0	2.19865
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.23738
NEFM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060623
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8363
IGF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66289
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0228
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17547
SOCS3_KO_GDS3149_297_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.393
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2561
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29858
taurine metabolic process	GO Biological Process Annotations 2025	1.0	null
CDHR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02044
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11492_OE_Tnfsf15_SRP106312	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.08739
account	GeneRIF Biological Term Annotations	1.0	null
DQX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37902
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3823
CD320	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00403839
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24793
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Perturb_12705_KO_Tsc2_SRP227934	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.8047
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CLOCK	ChEA Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.846933
ORC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00843867
Kidney Neoplasms	CTD Gene-Disease Associations	1.0	1.44817
NDUFB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511872
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3054
MEFV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00778532
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05473
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24586
Epilepsy, Tonic-Clonic	CTD Gene-Disease Associations	1.0	1.04276
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF845	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35348
GCKR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520677
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02499
TRNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1317
CYTH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25375
CEBPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1352
GTEX-XPVG-0626-SM-4B65B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
DIMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88683
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer II of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12712
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.48633
BRD-K77345736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90213
BRD-K80359388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18178
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.891138
Ductus Arteriosus, Patent	HuGE Navigator Gene-Phenotype Associations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
N,N-dimethylaniline monooxygenase activity	GO Molecular Function Annotations 2023	1.0	null
Dizziness	CTD Gene-Disease Associations	1.0	1.63094
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STK38L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94178
SH3GL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14465
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71467
SQLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02354
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25986
CEP164	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.93729
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70568
PPARD_KO_GSE16048_54_mouse_pancreas (islets, PDX1-expressing cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-A03940741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14603
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66183
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1799
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0668
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.04794
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.22937
BRD-K12826618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03884
BRD-A89575866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76897
Thiopurine S-methyltransferase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
r1 part of the 'mesencephalic' trigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22943
SOCS3_KO_GDS3149_8_mouse_multiple cell types	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_8395_KD_Atoh8_SRP410862	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.18925
IFI27L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96322
BRD-K48970916_danazol_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE210885_3_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04036
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5207
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79239947_PF 573228_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HUH1	CCLE Cell Line Gene CNV Profiles	1.0	1.83673
ICC12	DepMap CRISPR Gene Dependency	1.0	2.54414
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34119
FLI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42195
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32723
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56988
BRD-K63987422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56724
BRD-K85606544_HKI-272_JHUEM2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2948_KD_Hnrnpk_DRP004738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.39282
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
GTEX-P78B-1026-SM-3NMC4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912489
Lung adenocarcinoma_LUAD_TCGA-44-6777-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
WBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35975
BRD-A75409952_wortmannin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62422
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840671
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.89
NADP	HMDB Metabolites of Enzymes	1.0	null
MAML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19806
ola	GeneRIF Biological Term Annotations	1.0	null
AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
als	GeneRIF Biological Term Annotations	1.0	null
suppression	GeneRIF Biological Term Annotations	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3117
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.82739
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mpk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40341
GTEX-POMQ-1426-SM-3P61D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16319
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5583
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7392-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3898
coenzyme binding	GO Molecular Function Annotations 2015	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
PMC2785767-1741-7007-7-79-S2.DOC-1-Day_28_IR_vs_OUT_4_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79455
BRD-K63997411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86895
IFT172	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78022
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.3522
TAL1_megakaryocyte_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
IRS1_KO_GDS1219_303_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HDLM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RNF187	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70543
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
RPL17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00736603
Dorsal column nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56723
NCOA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809968
Psychomotor Disorders	CTD Gene-Disease Associations	1.0	1.19345
BRD-K74095559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32407
GRIN2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00683712
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3869
studies	GeneRIF Biological Term Annotations	1.0	null
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-29a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.10104
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
DCAF12L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12837
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.87757
COPS7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03677
temporal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.947759
CALM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28035
biological_process	GO Biological Process Annotations 2015	1.0	null
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2014
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
endoplasmic reticulum lumen	GO Cellular Component Annotations 2015	1.0	null
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63879
NAMALWA	CCLE Cell Line Gene Expression Profiles	1.0	1.84967
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66584
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9886
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.05517
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916922
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868248
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paralysis	CTD Gene-Disease Associations	1.0	1.01587
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918244
G402	DepMap CRISPR Gene Dependency	1.0	3.43252
GSE114232_10_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Oxygen	HMDB Metabolites of Enzymes	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8208-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PARP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21377
spleen_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0297
coupled	GeneRIF Biological Term Annotations	1.0	null
PFKL_OE_GDS4410_202_human_biceps	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MMP26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540314
Perturb_2373_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.83143
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.976093
LHX1_NULL MUTATION - Ablation_GDS1748_749_mouse_Embryonic kidneys (from day E18.5)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Scleroderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
PMC3917856__F6	PFOCR Pathway Figure Associations 2023	1.0	null
LYPLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05876
MZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895904
TLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76489
BRD-K87743988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58775
Nicotine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
IGR1	DepMap CRISPR Gene Dependency	1.0	5.72253
BRD-K91094364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14949
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Central Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.42374
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3530456__F5	PFOCR Pathway Figure Associations 2024	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.990375
TRIM28	ChEA Transcription Factor Targets	1.0	null
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937684
Cholangiocarcinoma	CTD Gene-Disease Associations	1.0	1.44029
CERS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93716
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.81969
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11743
SDHAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52027
BRD-K06426971_Ryuvidine_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)	Reactome Pathways 2014	1.0	null
BRD-K78828094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42536
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ3S-1326-SM-4BOPQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920841
Kidney Chromophobe_KICH_TCGA-KN-8433-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17996
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE65617_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8175556-42003_2021_2140_MOESM6_ESM.txt--ZBTB10_ZBTB10	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD248	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065529
Uvula (IX)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43623
BRD-K09721123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72184
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610605
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.455
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7204
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial (fastigial) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6917
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0864
ZNF550	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26623
BRD-K04779531_NCGC00012852-02_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lorcaserin	DrugBank Drug Targets	1.0	null
ACTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462075
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36669
BRD-K77221985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59108
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81007
PMC8185471-mmc6.xlsx-up-_and_downregulated_genes-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_shared_FO_and_FC_regions_respectively_Related_to_Figure_6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5691-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57027
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PNMA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10562
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.66933
N-Desmethyltamoxifen	HMDB Metabolites of Enzymes	1.0	null
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85353
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.88765
BBS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63317
GSE211744_2_v_4_gdf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Benzydamine	CTD Gene-Chemical Interactions	1.0	null
EIF2AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58226
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)	Reactome Pathways 2014	1.0	null
MTPAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71141
BRD-K15615178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54318
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43956
GTEX-S341-1126-SM-4AD6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89738
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
HDAC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03569
retromammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25835
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91879
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	2.30005
sf-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.245017
Cholelithiasis	CTD Gene-Disease Associations	1.0	1.09716
YES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.796
RBM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50207
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_6_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
recent	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PELI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72011
Perturb_15537_KO_Setd2_SRP220248	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.05371
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
SOX2-21211035-GBM-HUMAN-BRAIN-GLIOBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
HERPUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30907
GSE210580_0_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
brain	GeneRIF Biological Term Annotations	1.0	null
CMPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689275
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74703
nucleobase-containing small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5823716-onc2017356x6.xlsx-350POS_noreps_txt-Supplementary_Table_4_ESC_SNAI1_FLK1hi_UP_Human_orthologs_of_top_350_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QM-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658217
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
CRCGN016_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34342
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IFNA21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442707
BRD-A77440546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15002
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.80202
FXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37398
G-401	GDSC Cell Line Gene Expression Profiles	1.0	1.61424
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.965928
dorsolateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15174
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03626
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF212	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703389
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.65489
GTEX-WL46-2026-SM-3LK7U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07525
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.996274
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9781
BRD-K47203692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11563
GSE206093,GSE206094_1_v_0_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RIMS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30722
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840671
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K80622725_STK397047_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5480-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PB-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15223_KD_FOXC1_SRP276213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.6265
YJEFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36034
Defective MAOA causes Brunner syndrome (BRUNS)	Reactome Pathways 2014	1.0	null
fmo3	GeneRIF Biological Term Annotations	1.0	null
MET_knockout_259_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.799157
GTEX-S33H-0326-SM-4AD6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09006
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NLGN1_KD_GDS4759_335_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Granulation tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
ARF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72964
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.66336
Hepatic Encephalopathy	CTD Gene-Disease Associations	1.0	1.53308
GTEX-O5YT-0926-SM-48TDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Sarcoma_SARC_TCGA-FX-A3TO-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554916
HMGB1P1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36545
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7662-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.876871
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
diethylstilbestrol_mus musculus_gpl81_gds982	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5497-01A-02R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.03679
CLDND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9804
CRCGN016_MCF10A.TP53.M_24H:N24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31998
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15928
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07441
hsa-miR-320a	MiRTarBase microRNA Targets	1.0	null
hsa-miR-770-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K80494270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26553
Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01952
DLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067922
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936373
response to osmotic stress	GO Biological Process Annotations 2015	1.0	null
dg3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.18
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.935264
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SHSY5Y	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00908
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5133
APECED - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy_Thymic epithelial cell_GSE85	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.07106
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59505
BRD-K30963311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16426
QRICH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00905109
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.23566
junctional zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.585224
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.7247
CMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16478
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CEP95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81626
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67623
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03495
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0619
BRD-K34234678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50386
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p1 part of the substantia nigra reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21088
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01087
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
parahippocampal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942232
FAD	HMDB Metabolites of Enzymes	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	2.16707
CRCGN010_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26632
PMC4125180__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60223
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83638
GTEX-XUJ4-1926-SM-4BOOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832484
DTX3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84199
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FE-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49653
A4 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08454
496100489_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01921
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11609
GSE207914_5_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.862603
PMC5777794-oncotarget-08-115570-s002.docx-0-HOXA10_HOXA10	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01627964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78247
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NU-DUL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10114
CD247	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648277
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0726-SM-32PML	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42286
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858804
MAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43065
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12634
Cimetidine	DrugBank Drug Targets	1.0	null
GSE254848_4_v_13_ptges_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62669
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.65113
Pulmonary Fibrosis	CTD Gene-Disease Associations	1.0	1.32488
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879623
Perturb_15717_OE_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.02084
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6732
Perturb_3817_KO_Atoh1_SRP076034	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.93603
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62S-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15742845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43793
superficial stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26203
IPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58763
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
alitretinoin_rattus norvegicus_gpl85_liver   b_gds2385	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Headache	CTD Gene-Disease Associations	1.0	1.53675
DHCR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512252
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74968
BRD-K05462252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5984
Magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02571
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830341
BRD-K76703230_YM-155_PC3_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Metaplasia	CTD Gene-Disease Associations	1.0	1.27132
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052543
Memory Disorders	CTD Gene-Disease Associations	1.0	1.66425
posteroventral (inferior) parietal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.3522
PAK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00565
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEP55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7244
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SBNO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00411652
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
SNU761	CCLE Cell Line Gene Expression Profiles	1.0	1.37823
ISG15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00838623
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.736
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.559652
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.05
FBXO48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08427
NABP1	Hub Proteins Protein-Protein Interactions	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853718
GSE248858_5_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
estradiol_mus musculus_gpl81_gse1839	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
PMC8725436-12864_2021_8226_MOESM3_ESM.xlsx-Sheet1-Table_S3_Target_molecules_of_NFE2L2_and_their_directional_changes_in_the_RNAseq_dataset_from_fasted_vs_12hrpf_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5301
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37651
PAPSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.0682
Respiratory Insufficiency	CTD Gene-Disease Associations	1.0	1.14473
BRD-K45928581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3003
RGS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488742
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.70265
SLC6A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7807
COL7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559432
BRD-K44432556_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A54490075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16904
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45137
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100458_FWM_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.55234
right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227186
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.15579
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847484
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087473
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.44139
PRAME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09836
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDR2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677903
SPRED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90627
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BM-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71668
rostral secondary prosencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07111
AMO1	CCLE Cell Line Gene CNV Profiles	1.0	1.55448
r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15148
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
TE-11	GDSC Cell Line Gene Expression Profiles	1.0	1.71686
Hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65441343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43609
Thyroid dyshormonogenesis 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
Edema	CTD Gene-Disease Associations	1.0	2.2892
Perturb_16509_OE_Yap1_SRP314492	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.9031
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WFJO-0826-SM-4LVM5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871736
GTEX-V955-0126-SM-4JBH5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907485
BRD-K51608472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3971
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4603
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC8791933-41598_2022_4817_MOESM4_ESM.xlsx-PAX7_up-Unnamed_1_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
Acidosis	CTD Gene-Disease Associations	1.0	1.06771
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5251
19061838-TableS13	GeneSigDB Published Gene Signatures	1.0	null
PCLAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75791
cofactor binding	GO Molecular Function Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.958
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06655
20188076-Table1	GeneSigDB Published Gene Signatures	1.0	null
496100354_PCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17307
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86011
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LTA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633505
PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951189
u698	HPA Cell Line Gene Expression Profiles	1.0	1.15956
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ALK_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Perturb_10322_KO_MYC_SRP310502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.69963
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.36047
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45421483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06201
MBIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47991
STXBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76304
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.33
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840671
TCF7L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05123
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9864
WDFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65677
KY821	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44565
GSE115363_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39483
EGR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057521
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38715
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r10 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25188
CD38	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663641
RALBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18362
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11256
ZNF420	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44522
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.810776
Dimethylaniline monooxygenase, N-oxide-forming	InterPro Predicted Protein Domain Annotations	1.0	null
CTCF-21964334-BJAB-B-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06338
BRD-K87524836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31712
nicotinamide nucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
dexamethasone_mus musculus_gpl339_gds2314	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29225
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K10136726_Na-Tosyl-Lys Chloromethyl Ketone, Hydrochloride_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disposition	GeneRIF Biological Term Annotations	1.0	null
BRD-K16064200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81813
Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853943
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ANTKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47012
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874181
BRD-K54212583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6814
OR10V1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662018
hsa-miR-3936	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
U138MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54265
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99251
GTEX-SJXC-0226-SM-2XCDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830366
NAMALWA	DepMap CRISPR Gene Dependency	1.0	2.7577
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48085
BRD-K65932559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85143
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
BRD-K61432982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77255
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566407
Perturb_14667_KO_Sirt3_SRP277814	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Breast Cancer_Mammary Gland Tissue_GSE2429	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.26793
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38137
BRD-K72414522_AZD-5438_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624523
BRD-K18000429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19998
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80457
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23901
WIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32718
Metabolism	Reactome Pathways 2014	1.0	null
Diagonal band	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
HK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26619
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.191456
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70175
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9708
GPM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591387
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83252
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IG-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALOX15B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509217
KSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699585
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.978907
BL41	CCLE Cell Line Gene CNV Profiles	1.0	1.89786
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MAFK	ENCODE Transcription Factor Targets	1.0	null
Pregnancy Complications	CTD Gene-Disease Associations	1.0	1.22821
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1853
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06934
Nitrate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
HT3	DepMap CRISPR Gene Dependency	1.0	4.14004
GTEX-NPJ8-2526-SM-2HML8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990283
MAP3K14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00751016
MEF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29053
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95928
BRD-K94277689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0051
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Hypercholesterolemia	CTD Gene-Disease Associations	1.0	1.4332
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NCIH526	CCLE Cell Line Gene CNV Profiles	1.0	1.45179
BRD-K31783598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43741
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAWR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695946
Perturb_10771_KO_Jnk2_SRP038635	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.14826
NZOV9	DepMap CRISPR Gene Dependency	1.0	5.22439
Intracranial arterial disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
IL27RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520533
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0682
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0115
BRD-K68949590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39002
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07094
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_2952_KD_Celf1_SRP003495	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.75215
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
secondary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SHANK3_KD_GDS4759_338_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZM-226600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97419
CCNO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0188
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X4EP-0826-SM-3P5YK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871575
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46455
BRD-K99530743_NCGC00242340-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S4UY-1426-SM-4AD6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882057
Prostate adenocarcinoma_PRAD_TCGA-M7-A720-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNFSF15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00716523
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	1.83983
HLA-DPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00751806
GSE207832_1_v_0_usp22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRGPRX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523047
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.95663
THEMIS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00849452
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927244
FMO oxidises nucleophiles	Reactome Pathways 2014	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.70927
SARS-CoV MA15_Day7-C57BL6_None_GSE50878	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.29037
LRRTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519139
EID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95716
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UR-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organonitrogen compound catabolic process	GO Biological Process Annotations 2023	1.0	null
CRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801755
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Reactome Pathways 2014	1.0	null
UBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96804
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02026
TLR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542771
CRCGN014_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1083
Brain Edema	CTD Gene-Disease Associations	1.0	1.32935
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13845
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Intracranial Hypertension	CTD Gene-Disease Associations	1.0	1.06116
hsa-miR-3916	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Voriconazole	HMDB Metabolites of Enzymes	1.0	null
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2643
GP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657849
GNAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50973
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81688
Arthritis	CTD Gene-Disease Associations	1.0	1.05648
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Distal tubular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15542_KD_Map3k7/Chd1_SRP201304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
USP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26617
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
16293578-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GUCY1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444784
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71346
Retinoschisis_Retina_GSE5581	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.847505
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51368
NELFE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634753
sf-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.676172
IRAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006489
nadph oxidation	GO Biological Process Annotations 2015	1.0	null
taurine biosynthetic process	GO Biological Process Annotations 2023	1.0	null
EXO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674299
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.925706
GTEX-SSA3-0226-SM-32QPN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17066
True leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.057
secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171884
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17683
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22786
PRDM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94743
GSE210885_3_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
predominates	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7081-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949426
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69557
USP32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72924
TMEM263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88813
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11137
BRD-K75679095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42504
Mesocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.132
NKX3-1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571799
BRD-K35209334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66578
Perturb_10873_KO_Slc25a34_SRP342539	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.36332
HARA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H510A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LIPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593577
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29709
TIA1_KO_GSE54418_262_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
17555561-Table2	GeneSigDB Published Gene Signatures	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.10842
STAC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545189
ALPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699764
PMC3513217__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K68336408_Tyrphostin AG 1478_SNUC4_6.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.153
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75173
Chloroplast photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.127
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65393
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.167856
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45124
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959752
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-ZBTB10_ZBTB10	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34255
GJD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052443
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87049
ACLY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0044543
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.09646
GTEX-OHPL-2426-SM-48TDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4118
CALCR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601721
Perturb_10261_KO_Esrrg_SRP119935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.87079
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6202
locus coeruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50054
TGW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43N-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210580_4_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
SNU119	CCLE Cell Line Gene Expression Profiles	1.0	1.5332
Flavin monooxygenase (FMO) 1	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K42436189_AZ20_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GOLT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24781
HUH6	CCLE Cell Line Gene Expression Profiles	1.0	2.03291
Cryptorchidism	CTD Gene-Disease Associations	1.0	1.25183
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2658
Fetal Death	CTD Gene-Disease Associations	1.0	1.93567
Inflammation	CTD Gene-Disease Associations	1.0	2.35666
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ACSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596351
BRD-K06117861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17252
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8479
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
occurred	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ENTPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46569
nadp metabolic process	GO Biological Process Annotations 2015	1.0	null
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4864
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43708
FOXO1_KO_GSE46025_480_mouse_CD8 T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861966
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93993903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3593
environment	GeneRIF Biological Term Annotations	1.0	null
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.718
SPSB1	Hub Proteins Protein-Protein Interactions	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05595
BRD-K55780532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.409
BRD-K08702524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91398
COL9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07272
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877553
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07583
GTEX-S3XE-0126-SM-4AD4R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924971
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39772
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
KYSE270	DepMap CRISPR Gene Dependency	1.0	2.56405
MKRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15345
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39948
BRD-K29850806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06833
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF613	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60701
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15141
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22537
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3593
Methimazole	CTD Gene-Chemical Interactions	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841736
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54915
ETV5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657437
CCT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29895
CSNK1G2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0041692
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Psychosexual disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
NCIH2029	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60032
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05229
ZNF772	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67023
preopto-hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11693
RTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60959
DDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.30875
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.287
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tamoxifen	DrugBank Drug Targets	1.0	null
Puberty, Delayed	HuGE Navigator Gene-Phenotype Associations	1.0	null
alkanesulfonate biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE131887_1_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
described	GeneRIF Biological Term Annotations	1.0	null
Metapathway biotransformation(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.11074
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.83046
Tamoxifen metabolism(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Color Blindness	DisGeNET Gene-Disease Associations	1.0	null
PITX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81416
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
HLCS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632769
BRD-K22185032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71026
Perturb_10305_KO_Cxcl12_SRP114370	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.97269
N,N-dimethylaniline monooxygenase activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K91879432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46494
L-428	GDSC Cell Line Gene Expression Profiles	1.0	1.42546
GTEX-Q734-0526-SM-2I3EH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840218
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06125
HEP3B217	CCLE Cell Line Gene Expression Profiles	1.0	1.48357
Kidney Failure, Chronic	HuGE Navigator Gene-Phenotype Associations	1.0	null
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01609
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15868
PDCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626678
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88031
Hematuria	CTD Gene-Disease Associations	1.0	1.42616
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
17850661-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S7SE-0226-SM-2XCD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2804
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5709-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4615_KD_Mlx_SRP231452	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.84769
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7407
HLA-DQA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593208
PMC12706077-44318_2025_598_MOESM21_ESM.xlsx-Dataset_EV19-hKidney_TPP-PISA-Genes_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86716312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26921
KIR2DL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058045
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.99193
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney Tubular Necrosis, Acute	CTD Gene-Disease Associations	1.0	1.29011
organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.093216
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K94325918_-666_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRR15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24883
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39616
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9132
KP-N-YN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE244072_11_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
15895078-FigureS2	GeneSigDB Published Gene Signatures	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.97244
BRD-K94862255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21949
transient	GeneRIF Biological Term Annotations	1.0	null
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)	Reactome Pathways 2014	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stat5b_18687707_colon_lof_mouse_gpl5759_gds3385	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.190283
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42309
EPHA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684797
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
UMOD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064155
osteoclasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02723
SMYD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048255
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44166
Demyelinating Diseases	CTD Gene-Disease Associations	1.0	1.27657
BRD-K56222361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67619
MBTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93107
trimethylamine monooxygenase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K56431031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96612
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180185_7_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64975
BRD-K78812164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09523
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03794
BRD-K63068307_ZSTK-474_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCDHB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2615
ATM_knockout_75_GSE23116	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.73158
Perturb_14552_KO_Abcc8_ERP018163	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHCR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31981
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8093
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Lung adenocarcinoma_LUAD_TCGA-44-2662-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57997
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978142
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943462
Microspore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.009
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
Lung adenocarcinoma_LUAD_TCGA-05-4420-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0577
BRD-K81142122_STK249718_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVOL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13265
showed	GeneRIF Biological Term Annotations	1.0	null
NUDT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59733
MORN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005952
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLCO2B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685294
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HGH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46691
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17306
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.83771
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	2.02265
BRD-K16266179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02336
TRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03031
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	1.83975
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.00533
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4681
19305503-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Perturb_8539_KO_Notch2_SRP152804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Phase I - Functionalization of compounds	Reactome Pathways 2024	1.0	null
BRD-K73808079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.03474
PPP1R3E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84351
BRD-K54053991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12988
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98534
spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233731
GRHL3_01_336	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.7373
GSE95685_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4676-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
drug metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K19009697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.30308
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.82905
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50807
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.7319
GOSR2	Pathway Commons Protein-Protein Interactions	1.0	null
RNR1	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K38975326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91158
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30144
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03231
TMEM243	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73084
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5431-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE237040_4_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.75934
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4273
ADHD and autism ASD pathways	WikiPathways Pathways 2024	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30152
Perturb_13654_Mut_HMGN1_SRP164924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.33979
Hydrogen Ion	HMDB Metabolites of Enzymes	1.0	null
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
HCT15	DepMap CRISPR Gene Dependency	1.0	4.11851
Child Behavior Disorders	CTD Gene-Disease Associations	1.0	1.02858
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ALPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595587
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838421
Perturb_15018_KO_Sirt6_SRP374172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.8984
Perturb_615_KO_SLFN11_SRP233180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.71277
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
hsa-miR-579	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Chlorosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.512
CBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55192
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08408
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840671
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.5305
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.933943
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-ZBTB10_ZBTB10	Rummagene Transcription Factor Associations 2026	1.0	null
SP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17578
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.01212
about	GeneRIF Biological Term Annotations	1.0	null
COLO678	DepMap CRISPR Gene Dependency	1.0	3.16717
BRD-K17061569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.77649
Hematologic Diseases	CTD Gene-Disease Associations	1.0	1.06771
BRD-K85935038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47925
17804718-Table1	GeneSigDB Published Gene Signatures	1.0	null
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17353
CLCN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26183
SPC25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644173
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45394
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.834
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A901-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spinal nucleus of the trigeminal, oral part, caudal dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03059
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43456
PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-Proximal_Tubule_Enriched_Genes_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
TBX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59064
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K62325456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.163
15869706-TableS2	GeneSigDB Published Gene Signatures	1.0	null
NECTIN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00838614
NELL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527654
ORM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053526
MRPL46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56171
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
CLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99969
GTEX-QVJO-1826-SM-447C9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31
RBMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59716
LIVF001-023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91183
HIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64373
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97292
Lung Injury	CTD Gene-Disease Associations	1.0	1.48967
Dyspnea	CTD Gene-Disease Associations	1.0	1.16368
MLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8643
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-Q734-0126-SM-48U1E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84298
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K98824517_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88836
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.83046
BRD-K35527855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90935
PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-ZBTB10_ZBTB10	Rummagene Transcription Factor Associations 2026	1.0	null
Daudi	GDSC Cell Line Gene Expression Profiles	1.0	2.54399
BRD-K53319404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.96347
RNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60827
PMC4521181-oncsis201520x8.pdf-141-ZGPAT_ZGPAT	Rummagene Transcription Factor Associations 2026	1.0	null
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.42913
BRD-K27665173_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0252
BRD-A24396574_celastrol_LNCAP_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
fmo	GeneRIF Biological Term Annotations	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23948
response to lipopolysaccharide	GO Biological Process Annotations 2015	1.0	null
HAO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0125284
RGL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058518
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3371
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56374
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV1-20927104-GIST48-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51597
ARPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08953
LC-1-SQ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37445
BRD-K94409042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4606
DOCK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41912
BRD-K88510285_B675700.cdx_A673_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CJ-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95651
RPMI-7951	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Palisade parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
ZNF627	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00893
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55849
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07755
BRD-K24815102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18021
BRD-K13873561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09559
ZNF480	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05141
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_12096_KD_Tsc22d1_SRP169507	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.46291
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.904305
HOPX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606695
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24842
GSE102870_5_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_0_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral amygdaloid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22839
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5554
MPZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640067
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058571
intermediate stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00242
PCGF4-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.24151
Perturb_9455_OE_Rnaseh1_SRP182028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.67117
NB1	CCLE Cell Line Gene CNV Profiles	1.0	1.54745
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Reactome Pathways 2014	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A09988375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26235
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36842
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05864
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18497
MAP3K15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054531
Perturb_10770_KO_Jnk1/Jnk2_SRP038635	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.55922
BRD-K00615600_AG14361_LOVO_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
coenzyme metabolic process	GO Biological Process Annotations 2015	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91973
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
hsa-miR-3664-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-ZBTB10_ZBTB10	Rummagene Transcription Factor Associations 2026	1.0	null
SOX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99352
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Adenoma of small intestine_Intestinal Epithelium_GSE422	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.66436
TUBA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523938
BRD-K80098154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00665
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7164
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5548
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1881
RALY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43463
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955294
BRD-K66189308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.7688
REST_01_337	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.70574
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56337
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC35D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22101
binding	GO Molecular Function Annotations 2015	1.0	null
GSE229231_0_v_1_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pyridine-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
SLC39A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64556
BRD-K59491389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00458
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organonitrogen compound biosynthetic process	GO Biological Process Annotations 2023	1.0	null
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67878
CEND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18194
BRD-K62312047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45346
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.878025
cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06533
diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
STX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32192
MTHFSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1607
intermediate stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85954
BRD-K12342133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34827
GSE210885_0_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46698
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44061
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159499
SNU407	CCLE Cell Line Gene CNV Profiles	1.0	1.53516
CRCGN013_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00118
GSE182834,GSE182836_2_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17123152-Table3a	GeneSigDB Published Gene Signatures	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.859356
hsa-miR-575	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
FABP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457923
UNC13D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643636
CRCGN015_MCF10A.WT.HP_24H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07491
hypotaurine dehydrogenase activity	GO Molecular Function Annotations 2023	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.57571
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1578
GSE146074_10_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	2.67164
glutamate-cysteine ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.602
essentially	GeneRIF Biological Term Annotations	1.0	null
Perturb_3417_KO_Cdx2_SRP093647	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K09975370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.86913
Perturb_13585_KD_Tardbp_SRP314028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.9411
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7389
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.829777
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K47366416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18391
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.926919
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Anorexia	CTD Gene-Disease Associations	1.0	1.75321
periventricular stratum of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02865
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75036
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.54843
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSP90AB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666257
BRD-K64836560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53254
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4468_KO_Cnr1_SRP346447	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.17351
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91817
BRD-K78126613_MENADIONE_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCEAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14717
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52138
Myoclonus	CTD Gene-Disease Associations	1.0	1.04941
Lung adenocarcinoma_LUAD_TCGA-44-6775-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05112
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COX6B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595431
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26836
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055985
BRD-K52552873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14213
GTEX-WL46-0326-SM-3LK6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22216
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PCYOX1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83569
downregulated	GeneRIF Biological Term Annotations	1.0	null
GSE161842_1_v_2_kdm6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
noxidation	GeneRIF Biological Term Annotations	1.0	null
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76978
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49526
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049743
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZDHHC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11158
Perturb_5385_KO_Isl1_SRP380182	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.3765
thiamine_rattus norvegicus_gpl2896_gse19292	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23723
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05342
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1032
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838037
RDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56506
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.146
P2RY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92601
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9376
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25835
Secondary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.273
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.93798
hepg2	GeneRIF Biological Term Annotations	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39123
TLR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00859213
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09019
psych	GAD High Level Gene-Disease Associations	1.0	0.293278
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
HADHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67398
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Perturb_3195_KO_Poldip2_SRP302743	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.5305
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
HAPSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53655
CATSPER3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603282
BRD-K16304302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53077
DHODH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693561
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
CJM	DepMap CRISPR Gene Dependency	1.0	2.21602
posterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53408
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
496100598_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.06484
GTEX-S7SF-0926-SM-4AD4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976418
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FAHD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41127
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Flavin monooxygenase FMO	InterPro Predicted Protein Domain Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26599
KYAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066505
BRD-K66327237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52666
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
MSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501418
EZH2	ENCODE Transcription Factor Targets	1.0	null
BRD-K00615600_AG14361_PC3_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SYVN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07971
membrane region	GO Cellular Component Annotations 2015	1.0	null
BRD-K82674931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10321
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590137
Heart Septal Defects, Ventricular	CTD Gene-Disease Associations	1.0	1.31178
Meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
SUN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19222
RPMI-7951	GDSC Cell Line Gene Expression Profiles	1.0	2.07253
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	1.31805
Riboflavin synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.974
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_HA1E_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
response to biotic stimulus	GO Biological Process Annotations 2015	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5646
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12634
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
flavin adenine dinucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72077
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70515
GSE211744_2_v_0_gdf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KPL1	DepMap CRISPR Gene Dependency	1.0	2.05616
Perturb_8513_KO_Setd1b_SRP328849	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.63105
Th-1 cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
PPAR-Beta_DELETION_GDS4320_363_mouse_Pancreatic beta-cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90931
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11995
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86411
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K16485616_mocetinostat_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40718
GSE201251_2_v_3_coumarin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nephritis	CTD Gene-Disease Associations	1.0	1.07553
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889599
A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_7day-MOI-10^4_None_GSE37572	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.73352
BRD-A88691416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04429
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67181
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SKP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44159
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24046
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8181
J82	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16597
Cerebrovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
contribution	GeneRIF Biological Term Annotations	1.0	null
BRD-A30205217_Ethotoin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKIC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.79275
DHPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57021
dorsolateral IC periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0296
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.980158
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QG-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NMRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09183
NPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00483918
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-8693-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919125
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_15718_OE|KD_Ctcf|Smarca5_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.4143
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14837
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.3033
lateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20935
RH-18	GDSC Cell Line Gene Expression Profiles	1.0	3.60049
GTEX-OHPL-1326-SM-3MJGG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05458
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_NCIH1694_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LIN28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27911
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2324
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.837056
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918244
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8500868-401_2021_2354_MOESM5_ESM.xlsx-GEP_PATZ1-Gene_Symbol_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2672
Interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2022
UCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7812
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.852102
KU1919	DepMap CRISPR Gene Dependency	1.0	2.29485
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04988
BRD-K94992087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37117
inner SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27437
Intramolecular phosphotransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.004
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58472
response to stress	GO Biological Process Annotations 2015	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45061
Perturb_5816_OE_Erg_SRP239807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Perturb_3907_KO_DUSP6_SRP229874	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6856_KD_CNOT1_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.51929
GTEX-X5EB-2426-SM-4E3HX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893267
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.99852
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.827019
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56155
BRD-K43834805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58778
kidney	HPA Tissue Gene Expression Profiles	1.0	2.19274
dilazep-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51732
BRD-K01436366_XMD-1150_LNCAP_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRK-0126-SM-3NB1E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.049
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91973
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15106
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33111
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25497
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998217
CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TMEM101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34565
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82164249_S1140_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NDUFA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005506
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19721
CORL105	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71086
SMIM24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33885
Perturb_10286_KO_Ypel3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.3152
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00622
Perturb_6870_KO_PCIF1_SRP321924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.44142
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Thyroid Neoplasms	CTD Gene-Disease Associations	1.0	1.04574
19286929-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DGKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25489
Defective CYP1B1 causes Glaucoma	Reactome Pathways 2014	1.0	null
LHFPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14481
LSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39569
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88573743_A443654_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22063616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24825
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.84524
HS936T	DepMap CRISPR Gene Dependency	1.0	3.62739
GAPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523142
RNF207	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92699
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9101
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8971
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NCI-H2291	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OCILY3	CCLE Cell Line Gene Expression Profiles	1.0	1.92847
BRD-K07502463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00286
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19884
BRD-K46306128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77866
time	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H292 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
APPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04482
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81689
r10 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14748
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
periodontal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.465416
FOXM1_02_37	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.67807
intermediate stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14748
CLEC4M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620257
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13311
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6439317-Table_4.XLSX-NR2F6-Supplementary_Table_4_Genes_with_significant_correlation_with_NR2F6_NR2F6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_17620_KO_MLLT6_SRP245883	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.2655
Perturb_11423_KD_AR_SRP324259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.1898
RASAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4037
PMC11938024-ADMA-37-2413413-s001.xlsx-Table_S1a_DE_Genes_analysis-Table_S1a_Differentailly_expressed_genes_Control_vs_NPs_treated_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
SHPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652714
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A19500257_geldanamycin_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K74148702_curcumin_RKO_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A28105619_curcubitacin I_H1299_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21982562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52888
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
sulfur compound catabolic process	GO Biological Process Annotations 2023	1.0	null
CLCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636548
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GALNTL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570784
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.3522
response to chemical	GO Biological Process Annotations 2015	1.0	null
UMC-11	GDSC Cell Line Gene Expression Profiles	1.0	1.90481
BRD-K78659596_MLN2238_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_326_KO_CDK12_SRP334730	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.86629
stress	GeneRIF Biological Term Annotations	1.0	null
oxidoreduction coenzyme metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91926
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88176
carboxylic acid catabolic process	GO Biological Process Annotations 2025	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.68
t70-white-adipose_male_2w	MoTrPAC Rat Endurance Exercise Training	1.0	2.03812
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13317
GIMAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497657
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3T3-F442A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64544
BRD-K78218619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0186
GTEX-WRHU-0326-SM-3MJFY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09454
GPR50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73701
GSE188870,GSE188871_0_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.04444
methylprednisolone_rattus norvegicus_gpl341_gds972	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53931904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18476
Myositis	CTD Gene-Disease Associations	1.0	1.29164
Prostate adenocarcinoma_PRAD_TCGA-HI-7168-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2-aminopyrimidine	CTD Gene-Chemical Interactions	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Ischemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
posterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31577
Hemolysis	CTD Gene-Disease Associations	1.0	1.58208
STAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615578
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09499
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.65721
AVL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15831
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838796
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95785537_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OPM2	CCLE Cell Line Gene CNV Profiles	1.0	2.32676
SERPINA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712733
Perturb_10726_OE_Sirt6_SRP282071	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.41791
WM2664	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72447
intermediate stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58165
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Trimethylamine	HMDB Metabolites of Enzymes	1.0	null
NECTIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577848
GTEX-XV7Q-2426-SM-4BRV8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21173
GSE165548_2_v_7_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	6.4529
CCDC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51726
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0823
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.670726
BRD-K86995890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54162
Lung adenocarcinoma_LUAD_TCGA-49-6744-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.75102
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Hair follicle bulge stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39397
BRD-K11307720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14344
Fatty Liver	CTD Gene-Disease Associations	1.0	2.41941
FAM219B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77363
TIMP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00842694
PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-ZBTB10_ZBTB10	Rummagene Transcription Factor Associations 2026	1.0	null
RGS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27163
BRD-K87737963_CYT387_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JH-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
liminal part of the r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03871
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Disorders of Sex Development	CTD Gene-Disease Associations	1.0	1.18456
Papilledema	CTD Gene-Disease Associations	1.0	1.26083
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74009886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20313
GTEX-P4PP-0926-SM-48TBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
all	GWASdb SNP-Phenotype Associations	1.0	0.028394
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
TRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76422
GTEX-OOBJ-0526-SM-48TDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72458
RERFLCAD1	DepMap CRISPR Gene Dependency	1.0	2.19092
VANGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36048
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53155
BRD-K78659596_MLN2238_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50818
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46042
Tapetum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
DACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25179
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.36098
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
BAIAP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69412
Thrombocytopenia	CTD Gene-Disease Associations	1.0	1.57402
Dyslipidemias	CTD Gene-Disease Associations	1.0	1.28272
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V6-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-2026-SM-3DB78	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869295
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25491
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)	Reactome Pathways 2014	1.0	null
KCNK13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482107
PDX1_KO_GDS4348_360_mouse_Proximal small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-649	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ILK_activemutant_78_GSE25729	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.96117
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07632
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4ND-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14122_KD_Tcf4_SRP061034	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46788
NAD(P)-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-N7MS-0326-SM-4E3K2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08119
BRDT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602627
KIF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70037
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20566
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.956216
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13896
PMC3665348__F8	PFOCR Pathway Figure Associations 2023	1.0	null
EDEM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56139
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37712
PRKAR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623336
BRD-K33767223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00059
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16402
STAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.012405
Perturb_6249_KO_Chrna7_SRP338769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.1705
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma	CTD Gene-Disease Associations	1.0	1.14954
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.71308
Astrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80308
PTTG1IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09102
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
CD300A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621394
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040452
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
Leukopenia	CTD Gene-Disease Associations	1.0	1.23993
BRD-K45947503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96475
BRD-K24680618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38884
intracellular part	GO Cellular Component Annotations 2015	1.0	null
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24935
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Lung adenocarcinoma_LUAD_TCGA-38-4627-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10903_KO_Ppp1r3c_SRP019798	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.88623
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-3611	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.89545
Lung squamous cell carcinoma_LUSC_TCGA-18-3419-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10333_KO_miR17~92_SRP093233	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.78027
SK-MEL-31	COSMIC Cell Line Gene Mutation Profiles	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.968955
red nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05048
P2RY12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00706202
GSE131425_2_v_3_arg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF766	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43293
methyl 4-tolylsulfide	CTD Gene-Chemical Interactions	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.125
SPIRE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38714
BRD-K81782447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70473
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838421
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97362
LNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35106
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	1.40408
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94994
intracellular organelle lumen	GO Cellular Component Annotations 2015	1.0	null
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.854296
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02822062_CT-200783_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03871
OCIAML5	CCLE Cell Line Gene Expression Profiles	1.0	1.79972
FHIP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18964
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
develop	GeneRIF Biological Term Annotations	1.0	null
Perturb_9690_KO_RNASEH2B_SRP355094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.17535
ERG28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66298
ZNF107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27108
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SK-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K07431402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73626
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02181
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5712-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ESR1_KD_GDS4065_452_human_MCF7 estrogen-sensitive breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.847968
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.054
Primary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.719
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
spleen	HPA Tissue Gene Expression Profiles	-1.0	-1.17805
BRD-K19752998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08199
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52934
GLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050486
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9809
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14773
CDK11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19507
BRD-K76600600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26979
Perturb_6838_KO_DOHH_SRP199981	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.97647
MYB-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
nucleoside phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
RERFLCAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24017
placenta	HPA Tissue Protein Expression Profiles	1.0	0.996274
SEC24D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74631
HUCCT1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68797
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
APAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573074
CLDN18_KO_GDS4961_28_mouse_whole lung tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
outer SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844521
BRD-K00191683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19422
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intermediate stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03892
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74533
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4622-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67088
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18001
carboxylic acid catabolic process	GO Biological Process Annotations 2023	1.0	null
GBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486695
Thyroid Diseases	CTD Gene-Disease Associations	1.0	1.35849
GLS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00864226
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0989
BRD-K12879624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03951
postcentral gyrus, right, bank of the posterior central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3243
bleomycin_mus musculus_gpl339_gds1492	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35403
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Uvula (IX), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30437
ATXN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560018
bleomycin_mus musculus_gpl81_c57bl6j_gds251	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062283
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881582
CIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03749
Perturb_228_KO_Lmx1b_SRP194283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.89385
BRD-K04010869_PROSTAGLANDIN A1_NCIH1694_6.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF740	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.894
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.54791
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
superficial stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42363
PINK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46246
mammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25875
Carbon Tetrachloride	CTD Gene-Chemical Interactions	1.0	null
BRD-K39685923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06751
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32841
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Sexual health disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.589
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830065
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-1.10754
Brain Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73551
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33089
CAOV-4	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
BRD-K79090631_CGP-60474_HS578T_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PLEKHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36139
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
AP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46095
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
TYKNU	DepMap CRISPR Gene Dependency	1.0	2.21513
CEP83	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00824824
MFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64608
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22151
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864049
BRD-K03361106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33127
Vision Disorders	CTD Gene-Disease Associations	1.0	1.16567
Perturb_9543_KO_Ucp1_SRP187003	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.79868
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.975857
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40252
snp	GeneRIF Biological Term Annotations	1.0	null
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.08783
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.789
DUSP11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628242
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
RPS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22492
organelle lumen	GO Cellular Component Annotations 2015	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
PMC4496795-srep12063-s2.xls-STAT1_subnetwork-Gene_symbol_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69406317_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_10883_KO_Trp53_SRP322469	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.53853
BRD-K51575138_TPCA-1_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95995661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08282
TBC1D7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96288
Heart Failure	CTD Gene-Disease Associations	1.0	1.5678
CR1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562156
irinotecan_rattus norvegicus_gpl1355_gds3466	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96979108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02434
PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27055
EFNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541684
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
response to oxygen-containing compound	GO Biological Process Annotations 2015	1.0	null
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002908
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.631
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879623
r9 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08692
SLC18B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58933
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Alkyl hydroperoxide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
SYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9831
GTEX-VJYA-1726-SM-3NMDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17026
PMC11758349-11130_2024_1262_MOESM1_ESM.docx-4-RFXDC2_RFX7	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.38795
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K53491881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31872
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.04574
FAM89B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00901491
Breast Cancer_Mammary gland_GSE2528	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.92935
anion binding	GO Molecular Function Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MLYCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40696
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GAMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36253
BRD-K67007076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20352
SSX2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97577
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446422
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
PRLR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615858
BARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8257
Lung adenocarcinoma_LUAD_TCGA-44-4112-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40001806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72726
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23726
CRCGN010_HEPG2_24H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08346
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00908
PMC10610100__F2	PFOCR Pathway Figure Associations 2024	1.0	null
FBXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98298
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864049
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60837
Fetalliver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NICOTINE POLACRILEX	DGIdb Drug Targets 2026	1.0	0.820651
t99-vena-cava_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.87759
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Myocardial Ischemia	CTD Gene-Disease Associations	1.0	1.06987
fetal	GeneRIF Biological Term Annotations	1.0	null
SPOCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00873863
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
SP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845554
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74968
PKBalpha_KO_GDS1784_196_mouse_Embryonic fibroblasts (MEFs) - 24h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52359
Hepatomegaly	CTD Gene-Disease Associations	1.0	2.40706
cerebellar nuclei of CbV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6917
CISD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647652
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873216
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.999096
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8260-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1038
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10995
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81786
ASPRV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52734
TNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58718
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE126127_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07848
Uterine Diseases	CTD Gene-Disease Associations	1.0	1.30482
Hyperplasia	CTD Gene-Disease Associations	1.0	2.48225
Ataxia	CTD Gene-Disease Associations	1.0	1.35155
CD40LG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630269
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
adult	GeneRIF Biological Term Annotations	1.0	null
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35438
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HLTF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00353015
BRD-K46074482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.03032
CHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80528
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MC116	CCLE Cell Line Gene Expression Profiles	1.0	1.40883
STAT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625567
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
OC316	DepMap CRISPR Gene Dependency	1.0	2.54152
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
BRD-K22244754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19088
r9 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2586
HDGFL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590787
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0854
BRD-K13086002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.595
Perturb_17412_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
YAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08865
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6998
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.953443
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.122
SOX9-26525672-CHIP-SEQ-LIMBBUDS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.3522
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mutated	GeneRIF Biological Term Annotations	1.0	null
TMEM268	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27865
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979553
BRD-K98944347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96997
BRD-K03733288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51707
estradiol_bos taurus_gpl2112_gse45857	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Chloroplast photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.383
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SQSTM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755876
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.95143
BRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22195
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37712
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03517
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48441
BRD-K51878684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19907
SW1271	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62984
BRD-K72278003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3793
PKNOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97737
Casparian strip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30378
PTEN_KD_GDS4759_337_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06037
2313287	DepMap CRISPR Gene Dependency	1.0	2.11741
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ELF4_ELF4	Rummagene Transcription Factor Associations 2026	1.0	null
Plasma membrane-derived chromatophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
Medullary reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85207
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15287
HNF4alpha_KO_GDS1916_168_mouse_Embryonic liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
small intestine	HPA Tissue Gene Expression Profiles	1.0	1.06449
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03177
kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879623
BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O5-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.10803
Pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leaf vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.959637
FZD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89104
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5501_Mut|KO_Hras_SRP026484	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.43809
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-160-ZNF20_ZNF20	Rummagene Transcription Factor Associations 2026	1.0	null
4-fluoroaniline	CTD Gene-Chemical Interactions	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09019
GTEX-WHPG-2626-SM-3NMBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17522
D458	DepMap CRISPR Gene Dependency	1.0	4.03451
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21371
BRD-K15174326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51889
Sarcoma_SARC_TCGA-FX-A3RE-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
BRD-K89320330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47832
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FEZ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706381
S1PR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593251
SIX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08422
MFSD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93614
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54976
MET_knockout_258_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.874626
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
FGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694625
RAD23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77097
BRD-K94876980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10933
ARHGEF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38866
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63756
647-V	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49589
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K33044659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46443
Perturb_13374_KD_L54E2_SRP225936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K44387261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0506
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15319
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3559
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27656
BRD-A56592690_PX12_RMGI_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMARCAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17038
PFSK1	DepMap CRISPR Gene Dependency	1.0	6.40844
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19881
TEAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17686
Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C1orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69959
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80524
BRD-K27915221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42571
PMC5515859__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76674262_Homoharringtonine_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BICRAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27205
17873912-Table1	GeneSigDB Published Gene Signatures	1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NDEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84851
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-2.03825
SKIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36573
BRD-K62714735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61371
CHD1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-A54769817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09177
KCNMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497404
GFER	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444981
S100A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42539
Infant, Premature, Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
RAPGEF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691702
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97385
Plasmodesma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
planum polare, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881074
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
significant	GeneRIF Biological Term Annotations	1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865732
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26004
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055246
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47806
GTEX-PSDG-1326-SM-48TD2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09219
SCGB3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72848
BRD-K57356416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37875
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06297
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)	Reactome Pathways 2014	1.0	null
CEACAM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054805
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14052_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.46101
4-fluoro-N-methylaniline	CTD Gene-Chemical Interactions	1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
LCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00743998
BRD-K48478472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54188
KCNE4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518638
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	2.36038
Endoplasmic reticulum lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879623
KCNQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18732
PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAOV4	DepMap CRISPR Gene Dependency	1.0	2.70606
GTEX-TML8-0926-SM-4DXSJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32997
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.50838
PCTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42512
within	GeneRIF Biological Term Annotations	1.0	null
Perturb_11331_KO_Nr1d1/Nr1d2_SRP241717	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.59032
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24592
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68409
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	1.0	3.05826
TAFAZZIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061334
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
CP67-MEL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56639
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10356
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953898
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Hypothyroidism	CTD Gene-Disease Associations	1.0	1.2975
cellular process	GO Biological Process Annotations 2015	1.0	null
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30054
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.713064
IMPDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416472
ZNF507	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59557
PGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25147
LI7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48623
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16686
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75712
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839217
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565631
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lipidoses	CTD Gene-Disease Associations	1.0	1.06625
consequence	GeneRIF Biological Term Annotations	1.0	null
CNNM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88842
GTEX-SIU8-0226-SM-2XCDS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950829
PTK7_KD_GSE50138_675_human_H2009	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-1.08783
GTEX-PW2O-0008-SM-48TEB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08062
Diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MFSD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66983
NCI-H1876	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
BRD-K23868551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5973
Perturb_15080_KD_Chd8_SRP354984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.9138
NFE2-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TP53BP1_KD_GSE54268_670_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PEDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65268
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW403	DepMap CRISPR Gene Dependency	1.0	3.43441
Perturb_11717_KD_MBD2_SRP194625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.32246
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.951
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72804
BACE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36369
Estradiol	CTD Gene-Chemical Interactions	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39429
cerebellar nuclei of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39711
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5585-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
methylprednisolone_rattus norvegicus_gpl85_gds965	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99939253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55756
Tamoxifen metabolism	WikiPathways Pathways 2024	1.0	null
SLC19A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725503
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SUSD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581008
TTBK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778712
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.36693
BRD-K51757923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16966
BRD-K15794956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55462
FAM98A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05078
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839256
Thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04303
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.976093
specific	GeneRIF Biological Term Annotations	1.0	null
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825095
Mental Disorders	CTD Gene-Disease Associations	1.0	1.73008
BRD-K32176914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18852
PARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10388
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97444
ARID5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4627
FOS	ENCODE Transcription Factor Targets	1.0	null
19305503-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WL46-0426-SM-3TW8J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947921
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6311_KO_MIR221/MIR222_SRP073023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.33899
H3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69885
Sarcoma_SARC_TCGA-DX-A8BX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
BRD-A99687212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04841
Metabolism of amino acids and derivatives	Reactome Pathways 2024	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831988
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.862603
Lung adenocarcinoma_LUAD_TCGA-J2-8192-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcosinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34198
BRD-K55399138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20147
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VPS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98919
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.89829
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72199
BRD-K44103530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73992
terminal paraventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08029
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919125
PYGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00408238
TFB2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82784
Midbrain trigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64172
BRD-K97223487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98152
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	6.18919
TNFAIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591091
PTPRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554091
BRD-K88756517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21544
CHEK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18123
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.953593
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
PPP2R5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496209
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YP-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.54577
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XOT4-0726-SM-4GIAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34249
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A08003242_RHODOMYRTOXIN B_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61152
pharmacology	GeneRIF Biological Term Annotations	1.0	null
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0799
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
glis2_17618285_kidney_lof_mouse_gpl2897_gds2817	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.515582
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33293
CI1	CCLE Cell Line Gene Expression Profiles	1.0	1.61028
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4133
hsa-miR-105	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
BRD-K62533881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.127
BRD-K43023353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06236
ABAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96371
GTEX-WY7C-0926-SM-3NB34	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00349
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A36630025_-666_AGS_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOT4-0008-SM-4B664	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5296
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8571
LEUTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78984
CBFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23746
r7 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77924
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
process	GeneRIF Biological Term Annotations	1.0	null
RGS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21761
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06363
Lung adenocarcinoma_LUAD_TCGA-MP-A4TK-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530618
CYLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0096
nucleus subputaminalis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891864
MAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057753
TMEM238	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85763
MCIXC	DepMap CRISPR Gene Dependency	1.0	2.88986
ARID5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421047
SH3BGRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29351
BRD-K94145457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43506
ZNF254	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48574
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF770	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24582
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846385
Exanthema	CTD Gene-Disease Associations	1.0	1.66425
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
RPS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41909
Dyskinesia, Drug-Induced	CTD Gene-Disease Associations	1.0	1.04389
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42318
G6PC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15211
BCPAP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82083
Porphyria Cutanea Tarda	CTD Gene-Disease Associations	1.0	1.02858
Proteinuria	CTD Gene-Disease Associations	1.0	2.04567
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.0895
GTEX-T6MN-0226-SM-32PMD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11202
GTEX-UPK5-2126-SM-4JBJK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871026
Kidney Diseases	CTD Gene-Disease Associations	1.0	2.38713
GSE110268_1_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0835
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.698
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Polycystic Ovary Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86111620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79495
NCF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629089
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07606
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.85006
BRD-K28168037_Fenretinide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HPGDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673401
BRD-K62794454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00513
BRD-A28153253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24681
BRD-K60080002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25015
BRD-K15433418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04336
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
n,n-dimethylaniline monooxygenase activity	GO Molecular Function Annotations 2015	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K22775880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05104
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
BRD-K67491390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2271
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.625
EGFL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22061
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Injuries	CTD Gene-Disease Associations	1.0	1.19113
BMI1	ChEA Transcription Factor Targets	1.0	null
GSE207914_4_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93219
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.814
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	2.42121
DDX51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06556
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4778
GSE228125_2_v_1_ptafr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SC-48788 (FOXG1)	NURSA Protein Complexes	1.0	null
0175029-0000-6875	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRAF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566001
BTNL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607804
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.16
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5073
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00661
RPL35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48372
19047173-tableS2	GeneSigDB Published Gene Signatures	1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1097
ATP6V1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01301
FOLR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00800507
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.922353
Splenic Diseases	CTD Gene-Disease Associations	1.0	1.09716
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21604
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K42789863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75644
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1636
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00894918
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56014
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.923698
ABCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57807
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1048
F5	DepMap CRISPR Gene Dependency	1.0	3.51859
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4726-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC30A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10886
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847381
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61328
Perturb_18499_KO_TWIST1_SRP121466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K08845546_FK506_NCIH1694_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
Perturb_8672_KD_Smyd4_SRP142426	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Pituitary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09564
FASTKD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063068
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4892
hsa-miR-3153	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
ATP2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5378
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.862603
Cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
TGM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514411
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08543
Reperfusion Injury	CTD Gene-Disease Associations	1.0	1.19639
GTEX-RWS6-1926-SM-47JXY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888299
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE241875_1_v_0_huwe1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PK59	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09437
MFN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29553
ADCYAP1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16251
gestational	GeneRIF Biological Term Annotations	1.0	null
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MOV10L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36432
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09933
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A3KF-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59817
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11051
GSE217363_6_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.82194
Perturb_17410_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6432
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3271
Fatigue	CTD Gene-Disease Associations	1.0	1.16035
RIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556581
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12683022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3353
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)	Reactome Pathways 2014	1.0	null
MEF2A_KD_GDS4759_340_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cerebellar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41375
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11499
FBXO11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52131
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.919
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95545
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00658
intermediate stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06836
MYL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57727
tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.417644
baclofen_mus musculus_gpl1261_gse17266	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070435
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8278
Schwalie et al.Nature.G2_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31372389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.73576
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)	Reactome Pathways 2014	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30875
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49622
endoplasmic reticulum lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MH-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58871
MMRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557917
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29305
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-A52024592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75473
SLC35A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06045
MAU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70755
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31797
RAB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15397
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.996274
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918244
PIGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71601
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.976093
BRD-K50129495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31756
AXIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37317
SDHD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00782079
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26298
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.835923
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29729
Superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15559
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8635-11A-01R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6552_KO_Il6ra_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.33714
CD83	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654165
Fenthion	CTD Gene-Chemical Interactions	1.0	null
DNAJC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85016
mantle zone of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1168
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AHSA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73438
OSRC2	CCLE Cell Line Gene Expression Profiles	1.0	1.35152
pyridine nucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM186	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29394
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
WDR90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54736
NCI-H1341	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ALK_KD_GDS2724_105_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K56593336_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
REXO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740357
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45023
Degradation of cysteine and homocysteine	Reactome Pathways 2024	1.0	null
BRD-A24396574_celastrol_BT20_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.791
MRPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5755
DSTYK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667622
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6155
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.59685
nucleotide metabolic process	GO Biological Process Annotations 2015	1.0	null
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-320-HSR	GDSC Cell Line Gene Expression Profiles	1.0	1.53922
BRD-K65836113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37886
ZNF318	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93801
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.5186
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.96315
BRD-K56751279_Y-39983_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.83183
ITGAE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00344967
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IQ-01A-31R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.222
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22085
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
RER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58459
RPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43754
CTB-1	GDSC Cell Line Gene Expression Profiles	1.0	1.95568
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.43421
NFYA_01_355	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61705
appendix	HPA Tissue Protein Expression Profiles	-1.0	-1.08783
Trimethylamine N-oxide	HMDB Metabolites of Enzymes	1.0	null
Perturb_16729_KO_miR301a_SRP131007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976297
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.56582
adiposetissue	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.947155
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9462
BRD-K94176593_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FMNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28867
Growth Disorders	CTD Gene-Disease Associations	1.0	1.33257
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
isopropyl alcohol_rattus norvegicus_gpl341_gse1888	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Diseases	CTD Gene-Disease Associations	1.0	1.27689
enzyme	GeneRIF Biological Term Annotations	1.0	null
18403781-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606956
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Hypotaurine	MW Enzyme Metabolite Associations	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36584
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.21304
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
ORMDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46607
TBXAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00851477
FOXF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47277
GSE244072_2_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17875932-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0008-SM-46MVK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49742
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ABCB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740677
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.10842
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05207
CHST12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52642
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.49252
KCNQ3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571148
SEC23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34472
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	2.129
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)	Reactome Pathways 2014	1.0	null
PRKAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87242
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.05427
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3930_KO_FURIN_SRP197346	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.29438
intermediate stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37064
BRD-K64748422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28888
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
whereas	GeneRIF Biological Term Annotations	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.49541
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18871
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886855
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5318-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71514806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.81805
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
involve	GeneRIF Biological Term Annotations	1.0	null
BRD-K24396618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74887
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864939
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70518736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55538
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.883
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62142
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38333
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536959
HKDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554259
CCDC124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48373
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.62246
GSE210885_0_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Root cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932366
SRSF7_02_02	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.45943
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
toxin metabolic process	GO Biological Process Annotations 2025	1.0	null
TMEM79	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65725
ZNF578	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88834
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NIBAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03398
TMSB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26108
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.189539
hearing loss	GAD Gene-Disease Associations	1.0	null
Perturb_16694_KO_Gpr34_SRP057563	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.41306
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19537
zona incerta	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.867832
STX5	Pathway Commons Protein-Protein Interactions	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1024
TEAD2_02_33	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.88753
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36669
GTEX-QDT8-0626-SM-48TYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1505
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913993
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
membrane	GO Cellular Component Annotations 2015	1.0	null
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.83912
Cystic Fibrosis_Lung_GSE3100	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.81875
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863086
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.60556
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09255
BRD-K12460566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66018
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
CFI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615888
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0214
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0682
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.35992
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1992
Microfibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.891
KCNJ12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599777
GSE70499_4_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31815
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37933
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47269
JMSU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82414
Lung adenocarcinoma_LUAD_TCGA-44-6145-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
C8orf76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32861
Perturb_6674_KD_HDAC9_SRP159451	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.83611
RNAi_-666_19345177	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Nutritional deficiency, NEC_Skeletal Myocyte_GSE1776	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.980475
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7255-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24586
Pancreas	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.990911
Hemorrhage	CTD Gene-Disease Associations	1.0	1.97361
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.996274
UFSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6069
PMC9181267-mmc5.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.33956
GB2	DepMap CRISPR Gene Dependency	1.0	3.94051
BRD-K14907323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11268
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33334
Perturb_8456_KO_FGFR3/FGFR4_SRP386785	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.64134
BRD-A67788537_Salermide_A375_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TE125T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66824
GTEX-O5YV-0526-SM-2I5GE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858239
RUNX1_01_245	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.02144
hepatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.258917
METAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00373363
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26622
Perturb_9774_KD_Kmt2e_SRP309338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.21545
Emphysema	CTD Gene-Disease Associations	1.0	1.02188
PMC3917856__F6	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_10323_KO_MYC/Setd2_SRP310502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.12758
SEC62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14138
BRD-A45014336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27547
IMPDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45435
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07743
Perturb_6857_KD_CNOT7/CNOT8_SRP287793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.52832
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	2.06264
CD3E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00824814
Perturb_16422_KO_Ring1/Rnf2_SRP136552	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.22506
Taurine and hypotaurine metabolism	KEGG Pathways 2026	1.0	null
TNNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34849
BRD-K39503511_MK-0591_A375_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K14788918_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Metapathway biotransformation(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Compound leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.94247
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2664
RAD51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93168
FKBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01459
Lung adenocarcinoma_LUAD_TCGA-78-8648-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HLA-C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10414
PKBalpha_KO_GDS1784_197_mouse_Embryonic fibroblasts (MEFs) - 48h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K44227013_ponatinib_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83391
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.51391
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
Ciliary pocket collar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.701
CRCGN015_MCF10A_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07116
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.872444
SW1088	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE88819_11_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01318
postpartum	GeneRIF Biological Term Annotations	1.0	null
BRD-K09108485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23567
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13381
SIN3B	ChEA Transcription Factor Targets	1.0	null
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K18635665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56039
BRD-A89067742_HTS 10765_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_9700_KO_TREX1_SRP355094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZFP90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5192
response to abiotic stimulus	GO Biological Process Annotations 2015	1.0	null
KDM5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476122
Perturb_3915_KD_CTNNB1_DRP003300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.82478
anterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69645
VPS35	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058449
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4859-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.172
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6209
Perturb_9485_KD_Appbp2_SRP359770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.7141
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
RPL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65988
EJM	CCLE Cell Line Gene Expression Profiles	1.0	1.43582
AFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30355
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8404
BRD-K25710391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04594
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3279
PNMA6F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66796
GTEX-W5X1-0008-SM-4LMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29002
AHRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79491
G401	CCLE Cell Line Gene Expression Profiles	1.0	3.40808
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64874
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.45419
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040865
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31284
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96344
GLRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586034
PGM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539003
GA-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929922
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09128
BRD-A16119053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11858
LILRA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00754032
BRD-K32195266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04628
Premature Birth	CTD Gene-Disease Associations	1.0	1.14336
Perturb_11854_KO_Fosl2_SRP131329	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.39323
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
LP1	CCLE Cell Line Gene CNV Profiles	1.0	1.61004
Fasciolar gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.839
Vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
CXXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19571
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.68235
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11298
MAST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704108
Amyotrophic Lateral Sclerosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
hsa-miR-3662	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE246195,GSE246305_4_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUH1	DepMap CRISPR Gene Dependency	1.0	2.05662
PTPMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35432
PRKAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3285
BRD-K91370081_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPHA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535866
FBXO21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62149
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23302
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K10882151_BO2 (inhibits RAD51)_PL21_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A94885304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91012
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06338
Sarcoma_SARC_TCGA-DX-A1L3-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
daudi	HPA Cell Line Gene Expression Profiles	1.0	1.19179
BRD-K50776152_cjd-pla-20-1_THP1_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mantle zone of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38812
titanium dioxide_mus musculus_gpl1261_non-pregnant_gds2878	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
response to molecule of bacterial origin	GO Biological Process Annotations 2015	1.0	null
ABCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95509
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03985
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07737
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
attaining	GeneRIF Biological Term Annotations	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07725
BRD-K33705415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09192
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06286
r10 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46552
NOP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6029
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VM-CUB-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6144
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
OXCT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40417
C12orf29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86576
Granuloma	CTD Gene-Disease Associations	1.0	1.3385
ZSCAN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67879
FCGR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491836
parolfactory gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.83914
BRD-K44946060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07756
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
TTLL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10914
ZR751	CCLE Cell Line Gene CNV Profiles	1.0	1.64866
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7836
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.670716
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.21611
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47806
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.11536
TAL1_01_217	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.44757
ALAS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679837
Lung Diseases	CTD Gene-Disease Associations	1.0	1.65292
WNK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045508
Lung squamous cell carcinoma_LUSC_TCGA-22-5489-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876139
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.97067
GATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08335
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SGK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632563
Perturb_7111_KO_Atf4_SRP344236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.65108
SLC7A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02931
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068188
BRD-K55220938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16375
BRD-K32881384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48081
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840671
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AAGAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77462
BRD-K19776718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84182
GTEX-PLZ4-1226-SM-2I5FE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38477
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.87725
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.864053
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2025	1.0	null
substantia nigra reticulata, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43956
NDUFA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00778453
BRD-A05883068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28592
GTEX-RU72-0626-SM-46MUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19067
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06403
BZW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40525
COMMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03588
BRD-K82506716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40463
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851529
Jaundice	CTD Gene-Disease Associations	1.0	1.85608
GTEX-XPVG-0526-SM-4B65N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60524
BRD-K44994529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00396
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.46858
PFKFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106634
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7037
Atrophy	CTD Gene-Disease Associations	1.0	1.85625
Vomiting	CTD Gene-Disease Associations	1.0	1.80359
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30908
GSE217363_0_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADPRH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63044
SAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.24591
inferior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35471
organic acid metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86836
CNIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74909
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04017
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)	Reactome Pathways 2014	1.0	null
PMC10742113__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-Q734-1826-SM-2I3EL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23994
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28264
NCI-H2452	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70357
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832025
BRD-K40758391_cjd-pla-49-3_NCIH1694_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2164_KD_Chd8_SRP062904	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.4075
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.851442
BRD-K77520720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55452
GSE175883_0_v_1_dis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21588
GTEX-QEL4-1426-SM-447AC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06464
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)	Reactome Pathways 2014	1.0	null
BRD-K71647210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28297
OGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00612892
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	0.977474
SERPINC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063861
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K39649723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.71517
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23316
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
response to external biotic stimulus	GO Biological Process Annotations 2015	1.0	null
4-aminophenol	CTD Gene-Chemical Interactions	1.0	null
r9 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74404
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
promoter	GeneRIF Biological Term Annotations	1.0	null
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09497
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27275
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29511
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.189539
HCC1428	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CALM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19596
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.61027
GTEX-X5EB-1626-SM-4E3IV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44116
BRD-K00007652_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57230817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07462
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18246
GABBR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529889
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.16279
HAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00359726
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8724
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14782
PYCARD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510713
cingulate gyrus, frontal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.836568
BRD-K68890376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13816
Amyotrophic Lateral Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
Perturb_18148_KO_Ikbkb_SRP285005	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.84383
intermediate stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00537
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939396
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB3IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772793
PTGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53292
GSE169571_3_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844277
BRD-A13082766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09717
RARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0512
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nausea	CTD Gene-Disease Associations	1.0	1.69701
NELFCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36282
birth	GeneRIF Biological Term Annotations	1.0	null
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0999
KIJK	DepMap CRISPR Gene Dependency	1.0	3.27615
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10411
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7667
PrPC_KO_GDS4352_358_mouse_Developing hippocampus from FVB newborns (4.5-day-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
VAESBJ	DepMap CRISPR Gene Dependency	1.0	2.9461
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02432
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
BRD-K76513704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92794
Lung squamous cell carcinoma_LUSC_TCGA-77-7142-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09903493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.8289
GTEX-R3RS-0626-SM-48FE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31378
HMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30624
K029AX	DepMap CRISPR Gene Dependency	1.0	4.03098
PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Kidney_GDS724_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
APTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87012
18032706-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12489
DU4475	CCLE Cell Line Gene CNV Profiles	1.0	1.75842
GSE112714_2_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNFA-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r8 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1168
assays	GeneRIF Biological Term Annotations	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17587
FGD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96266
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CD300LB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482604
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847381
Tremor	CTD Gene-Disease Associations	1.0	1.18359
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04303
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.465038
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Liver Cirrhosis, Experimental	DisGeNET Gene-Disease Associations	1.0	null
BRD-K48805623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33887
ZFP36_Deficiency_GDS2456_707_mouse_Fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K35687265_S1362_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2792
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29844
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
kidney	GTEx Tissue Gene Expression Profiles	1.0	1.38505
BRD-K82928847_rocilinostat_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.6371
GSE173840_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56097
response to organic substance	GO Biological Process Annotations 2015	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
BMI1-19503595-MEFC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
AEBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462444
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.524
HUPT4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68525
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K38131403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05011
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FTC133	DepMap CRISPR Gene Dependency	1.0	3.06039
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.957122
GTEX-OOBK-0625-SM-3LK5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863484
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35669
Confusion	CTD Gene-Disease Associations	1.0	1.60384
SGK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00428574
Perturb_13364_KD_Wwtr1_SRP079400	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.86229
Prostate adenocarcinoma_PRAD_TCGA-CH-5768-11A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFJO-2026-SM-4LVM3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35647
BRD-A15010982_10006350_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3648
ETV7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7622
CNR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00366301
Perturb_9538_KD_Jmjd3_SRP066186	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.4664
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.229
Ovarian Failure, Premature	HuGE Navigator Gene-Phenotype Associations	1.0	null
review	GeneRIF Biological Term Annotations	1.0	null
LIG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549024
TDG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49276
PGD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4636
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	2.15578
BRD-K28820796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.71467
BRD-K19085288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06826
H4C12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36844
NSF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463093
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Amyotrophic Lateral Sclerosis, Sporadic	CTD Gene-Disease Associations	1.0	2.88009
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.56769
Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.397
FBXO33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06775
BRD-K55479099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55541
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.979905
BRD-A96308662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60436
BRD-K98161738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94449
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.11255
GTEX-OXRO-0226-SM-3LK6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83102
Perturb_11739_KO_Nrf2_SRP108108	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.36908
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879623
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10984
NCIH157DM	DepMap CRISPR Gene Dependency	1.0	2.12707
GSE182834,GSE182836_8_v_3_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.90771
BRD-K35792251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.5557
oral mucosa	HPA Tissue Protein Expression Profiles	1.0	0.996274
BRD-K12251642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44388
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467937
TEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72645
Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11386
ROS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00767739
BRD-K22670776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05206
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EWSR1_KD_GDS4962_467_human_not specified	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43728
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2665-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Drug Hypersensitivity	CTD Gene-Disease Associations	1.0	1.63094
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918244
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.896675
Liver Diseases	CTD Gene-Disease Associations	1.0	2.33227
mc2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tamoxifen	HMDB Metabolites of Enzymes	1.0	null
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.38441
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Taurine	MW Enzyme Metabolite Associations	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.858614
RPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97466
SCIMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652105
FKBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57176
Perturb_11062_KO_Jup/Ctnnb1_SRP304535	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.3529
GSE157594_3_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6030-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A64849281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97984
COLO-741	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
horizontal nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2312
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73802986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43344
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PKBalpha_KO_GDS1784_193_mouse_Embryonic fibroblasts (MEFs) - 0 hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02852
TNFRSF21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00475587
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Glycosuria	CTD Gene-Disease Associations	1.0	1.20784
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
MSH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19412
Perturb_5512_KO_Eed_SRP136649	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.46397
DENND11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91305
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828108
GTEX-U4B1-0126-SM-4DXSN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04408
hsa-miR-759	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
ZNF256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54893
BRD-K78431006_HY-50878_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ZZEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0377
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45573
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.15141
BRD-K73872184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16053
Vandetanib	DrugBank Drug Targets	1.0	null
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54971
BRD-K14266419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37769
CRCGN011_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4362
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55665639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74024
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74253
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20925
WWTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19063
LSM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519895
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5680-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL11RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52129
toxin metabolic process	GO Biological Process Annotations 2015	1.0	null
ZMAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05073
BRD-K53032901_2-(trifluoromethyl)-10H-phenothiazine_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Perturb_11424_KD_KIF4A_SRP324259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.57286
TCEA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4955
NADP metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
GTEX-S4Z8-0126-SM-4GICC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20286
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Autoimmune Diseases	CTD Gene-Disease Associations	1.0	1.13007
RASD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25095
GRB10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471296
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48772
BRD-K73637411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19233
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.58688
MPND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23914
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6289
LSP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706471
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glycoprotein network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42898
B3GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68735
Cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54602
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20823
endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K92428232_HY-50877_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
drugs	GeneRIF Biological Term Annotations	1.0	null
BRD-K20331065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04101
hsa-miR-582-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K65427501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06552
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3762
Fastigial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77314
BRD-A08003242_RHODOMYRTOXIN B_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661228
NADP metabolic process	GO Biological Process Annotations 2023	1.0	null
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-WOFL-0826-SM-3MJG1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864484
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hydrastine hydrochloride-1740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SCN8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716081
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6685
PMC3499080__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K13390322_AT-7519_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RAB31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589862
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19073
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
CEM-VBL100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.438739
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE171269_1_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7192
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.29526
kidney_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.30637
XPO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06451
FOXA1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K21672174_Ro 28-1675 ?_A549_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
resulting	GeneRIF Biological Term Annotations	1.0	null
KMT2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611117
tonsil_8e1	HPA Tissue Sample Gene Expression Profiles	1.0	0.918245
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57051
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42273
Eye-limbal stem cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.118656
SKIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00368325
BRD-K05969019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17897
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3109
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
FLCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00854672
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Woronin body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
Perturb_10282_KO_Phpt1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.2005
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Drug metabolism - cytochrome P450	KEGG Pathways 2026	1.0	null
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.207
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
trimethylamine monooxygenase activity	GO Molecular Function Annotations 2025	1.0	null
K562	BioGPS Cell Line Gene Expression Profiles	1.0	1.35144
spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176355
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.039519
Female inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
Perturb_1027_KO_Ovgp1_SRP379795	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.93297
Hepatitis	CTD Gene-Disease Associations	1.0	2.19553
Lung adenocarcinoma_LUAD_TCGA-44-6774-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.7255
CNOT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70434
abundant	GeneRIF Biological Term Annotations	1.0	null
EP300-20729851-FORBRAIN-MIDBRAIN-LIMB-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59545
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4619
BRD-K61105081_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A94420133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.153
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUPT1	DepMap CRISPR Gene Dependency	1.0	2.86469
15084249-Table2	GeneSigDB Published Gene Signatures	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GPR65	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624081
PRDM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666954
suggested	GeneRIF Biological Term Annotations	1.0	null
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
Disseminated Intravascular Coagulation	CTD Gene-Disease Associations	1.0	1.4583
BMI1-19503595-MEFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870443
Intracranial aneurysm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
CACNB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00783718
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Perturb_15567_OE_TLR3_SRP341542	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.74863
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40069
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542203
Movement Disorders	CTD Gene-Disease Associations	1.0	1.08584
XYLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469771
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
endoplasmic reticulum lumen	GO Cellular Component Annotations 2023	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62N-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6414
GTEX-VUSG-2226-SM-4KKZO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872014
TAL1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.421529
Rhabdomyolysis	CTD Gene-Disease Associations	1.0	1.33228
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60866521_idelalisib_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211744_2_v_5_gdf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05531
Inflorescence apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
EZH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00352352
TRABD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69308
DOK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00775627
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15287
ACTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652965
Perturb_7124_KO_Prkcd/Prkce_SRP049245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.29075
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE226983_1_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DCTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68946
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929922
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.039519
GPX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04642
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2438
NEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24526
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06286
HMGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.943
TNFSF14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00683849
ds19	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
ADORA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606242
GTEX-XOT4-0226-SM-4B66Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53123
Stevens-Johnson Syndrome	CTD Gene-Disease Associations	1.0	1.22274
Lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KYSE-510	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54971
oxidative	GeneRIF Biological Term Annotations	1.0	null
GATA6-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Seed coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
PRDM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38787
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
PMC4698384__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Biological oxidations	Reactome Pathways 2014	1.0	null
variant	GeneRIF Biological Term Annotations	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21897
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05839
RUNX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569176
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4297
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.41042
SHMAC5	DepMap CRISPR Gene Dependency	1.0	2.76017
UBA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72691
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO Molecular Function Annotations 2023	1.0	null
HSD17B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564043
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44512
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.26233
BRD-A60245366_AS-601245_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44061011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29025
Substantia nigra, reticular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00486
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GATA6-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A47416464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08815
DDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558193
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0886
urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16884266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79696
Rectum adenocarcinoma_READ_TCGA-DC-6158-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5815-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.873107
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
SOCS3_DELETION_GDS1254_80_mouse_ES (embryonic stems cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SIK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04213
taurine biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5589-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-1926-SM-3MJGB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01048
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
Cevimeline	HMDB Metabolites of Enzymes	1.0	null
Hallucinations	CTD Gene-Disease Associations	1.0	1.42156
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38766
TP63	ChEA Transcription Factor Targets	1.0	null
PMC4686057-pone.0145107.s001.xlsx-PAA-CAA-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A728-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15582_KO_Ctnnb1_SRP251042	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.60744
ACAD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40564
Prostate adenocarcinoma_PRAD_TCGA-EJ-7321-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3173
Perturb_11108_KO_Cpt2/Ppara_SRP303636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.74099
Lung adenocarcinoma_LUAD_TCGA-91-A4BC-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12423794-ao5c05859_si_001.pdf-16-PRDM1_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4256_KD_NCOR2_SRP326059	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45693
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77316284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46059
RUNX1_KO_GDS1511_250_mouse_Embryos at E8.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2172
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0016
PMC3530456__F5	PFOCR Pathway Figure Associations 2023	1.0	null
RH30	DepMap CRISPR Gene Dependency	1.0	3.12183
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22625
ENPP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00802958
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CEP72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078607
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1912
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NKRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93395
PCYT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00797838
BRD-K78867378_mw-A1-12_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049397
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
MAGED1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657436
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.837056
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.805969
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70828
CDHR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108048
Dermal fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.504
Infertility, Female	CTD Gene-Disease Associations	1.0	1.14989
Cerebral Hemorrhage	CTD Gene-Disease Associations	1.0	1.20654
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12184916_NVP-BEZ235_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488624
BRD-K85656316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04301
496100446_TCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12091
Venous Thrombosis	CTD Gene-Disease Associations	1.0	1.06479
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08335
Perturb_16508_OE_Rest_SRP314492	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.3592
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73652
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74025
Photosystem I reaction center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.55
GSE70499_4_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.019
DIPK2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52041
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56745
Sulfur amino acid metabolism	Reactome Pathways 2024	1.0	null
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.60575
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
JJ012	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955667
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.970443
Perturb_17820_KO_Bmal1_SRP260650	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.0458
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.919163
16790086-tableW1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70958
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45719
BRD-K06529600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8464
BRD-A48913311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08452
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25794
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85866
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.825739
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.48858
BRD-K61250553_Loperamide hydrochloride_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-24	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.07875
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43339
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.971947
BRD-A81879813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98904
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29072
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3727
intracellular organelle lumen	GO Cellular Component Annotations 2023	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20077
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K82091397_HY-11068_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOXD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95467
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06646
BRD-K54330070_SB 202190_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09805
FFAR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00397119
C16orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05009
SHOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94487
BRD-A68797623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15532
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36407
LOXIMVI	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45638
BTLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603585
BRD-K67319345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34065
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98237
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATF7IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53744
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GRM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649163
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.59288
POLH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22551
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.11223
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18493
BRD-K19894101_MST- 312_A549_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.838604
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.35743
PMC3513217__F3	PFOCR Pathway Figure Associations 2024	1.0	null
ACO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00422275
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KMS20	CCLE Cell Line Gene CNV Profiles	1.0	1.55602
primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37712
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866613
CAOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60356
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14681
BRD-K35026224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04215
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67655
STAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42229
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ENTREP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67309
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.38835
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2178
GALK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677012
age	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.879623
support	GeneRIF Biological Term Annotations	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ADGRF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647444
Perturb_17686_OE_HSD17B1_SRP366068	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.13381
Stromule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71089225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0231
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RN64-0126-SM-2TC68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24459
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.6447
BRD-K65824451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49499
EIF5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90811
MT-CYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9444
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74515
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
Lung adenocarcinoma_LUAD_TCGA-55-8089-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
BRD-K75038426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31815
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
ERBB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552713
SLC1A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559535
SW982	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GARRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81802
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.951686
BRD-K74305673_IMD 0354_NCIH1694_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.36275
18786252-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
CCDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49954
Linear nucleus of the medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70135
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NUSAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517499
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.99243
TPD52L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608375
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01031
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.962029
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1075
WBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80491
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18493
TBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35593
UMRC2	CCLE Cell Line Gene Expression Profiles	1.0	2.13763
TCF25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519564
SH3YL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26355
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.537098
GTEX-OHPN-0226-SM-48TBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44411
CAL51	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71702
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE126127_2_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12685
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.907379
Prostate adenocarcinoma_PRAD_TCGA-HC-8259-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710793
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
496100601_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96786
BRD-K21448715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55828
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33632
GFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96137
Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MTHFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24669
EHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055567
IL31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544997
alar part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22437
H3K27me3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851251
BRD-K67096761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76347
LRIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34579
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34159
NCAPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005082
childhood brain tumors ;  residential insecticide exposure	GAD Gene-Disease Associations	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
p53 decamer	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68182
Puberty, Precocious	CTD Gene-Disease Associations	1.0	1.09681
Perturb_6310_KO_MIR221_SRP073023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.71711
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.624
STN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66008
membrane-enclosed lumen	GO Cellular Component Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01294
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_201_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJHI-1426-SM-3DB9C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12498
RAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684582
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76968
metabolic process	GO Biological Process Annotations 2015	1.0	null
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.17337
KDM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543983
r1 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00633
factors	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEL4-0008-SM-447AZ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.37133
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848548
CDKN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56212
Hyperalgesia	CTD Gene-Disease Associations	1.0	1.63339
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57141
TM31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54158
15845616-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GPX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587588
Urticaria	CTD Gene-Disease Associations	1.0	1.02821
GSE143955_1_v_0_ripk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88625236_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE151160_0_v_1_cd36_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A07861932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42255
ENPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693841
HIRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66282
Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-T2IS-2226-SM-4DM65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13572
Infertility, Male	CTD Gene-Disease Associations	1.0	1.64056
SLC48A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17418
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Phase 1 - Functionalization of compounds	Reactome Pathways 2014	1.0	null
BRD-K24166534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15035
17875932-TableS3	GeneSigDB Published Gene Signatures	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.1017
Brain Diseases	CTD Gene-Disease Associations	1.0	1.61644
CREG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00425715
LRRN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576696
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.99898
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	0.871061
Disease	Reactome Pathways 2014	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7672-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85567359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47429
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TSPAN32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00998753
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.883
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MIA-PACA-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00848
IL18BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585094
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
VBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55819
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30356
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
TRUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30151
GSE248858_5_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Eosinophilia	CTD Gene-Disease Associations	1.0	1.04088
BRD-K22173650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04228
Perturb_7065_OE|KO_Hdac|Eed_SRP092655	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3294
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16467
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
response to external stimulus	GO Biological Process Annotations 2015	1.0	null
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087902
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993584
GSE131161_5_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.92386
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58543
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54981
PMCH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653683
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71745
Perturb_9130_KD_PHGDH_ERP020769	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.08423
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73945
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BFSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645955
SLC26A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00450201
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
organophosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.52623
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TJP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36916
Nerve ring	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
BRD-K79090631_CGP-60474_BT20_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NAP1L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5976
BRD-K46562329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13413
Liver Failure, Acute	CTD Gene-Disease Associations	1.0	2.05918
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864948
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53925
Pneumonia	CTD Gene-Disease Associations	1.0	1.17399
MFSD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66015
BRD-K04873321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1152
Perturb_13522_KD_Pbrm1_SRP333303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CHCHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33095
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.73232
15774477-Table1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85026
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06373
20211691-TableS1	GeneSigDB Published Gene Signatures	1.0	null
PODXL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00760642
GTEX-XLM4-0226-SM-4AT4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40602
intermediate stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46552
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NOL4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6795
Hyperlipidemias	CTD Gene-Disease Associations	1.0	1.65292
GSE86507,GSE86509_3_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8324-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSS	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46288
SLC32A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103446
MAGI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628226
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7
BRD-K67950754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.38576
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2036
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558215
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A67788537_Salermide_A549_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sudden cardiac arrest	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06412
KP-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.74504
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.68999
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18305
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_16531_KO_Cdk8/Cdk19_SRP351257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE131161_3_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0931
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	1.0	0.996274
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
xenobiotic metabolic process	GO Biological Process Annotations 2015	1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04163
spleen_3d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16949
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07799
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97593
TCF7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105624
PMC5703746-Table1.XLSX-ST6_MAF-GENE_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6373-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00816396
Perirenal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84753
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.703858
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29941
PHF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69601
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PEMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88979
COBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455435
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08867
Skin fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.471
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
PGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00436233
KMRC2	DepMap CRISPR Gene Dependency	1.0	2.10752
Perturb_12177_OE_PLK4_ERP132994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.38934
ESYT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56454
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86941
CHD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.003065
LIN28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35551
PMC5387099__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.37847
TBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.747
r2 part of nucleus subcoeruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07768
Perturb_12598_KD_Chd4_SRP366371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.36812
BRD-K55113501_Digoxigenin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COL4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00464608
FOXO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529814
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528942
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6213
BRD-K99525048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73773
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12178937-mmc6.xlsx-L_MAFF_KDvsL_C_deg_all-gene_name_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
HADH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
SRSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11042
Myocarditis	CTD Gene-Disease Associations	1.0	1.19477
E2F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631249
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UT7	CCLE Cell Line Gene Expression Profiles	1.0	1.64376
Dimethylaniline-N-oxide	HMDB Metabolites of Enzymes	1.0	null
FMO oxidises nucleophiles	Reactome Pathways 2024	1.0	null
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2288
CLDN18_KO_GSE48443_44_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HK-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65416
Lung adenocarcinoma_LUAD_TCGA-50-5045-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19293
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.293278
EDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67639
GSE158197_2_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SREK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11414
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.29225
CRCGN017_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10417
GTEX-XV7Q-2626-SM-4BRVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17732
Vasculitis, Leukocytoclastic, Cutaneous	CTD Gene-Disease Associations	1.0	1.12564
ERP27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588372
NT5E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00767817
Perturb_16821_KD_Miat_SRP379156	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC4060771-170289.f1.pdf-391-MEIS1_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
AK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90195
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065261
BRD-K62324460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02474
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00259
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.430695
TAOK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608286
BRD-K41287744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02232
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYBS-0926-SM-3NM94	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956709
PMC7940623-41467_2021_21725_MOESM11_ESM.xlsx-Extended_data_table_9_regulons-NR4A1_extended_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A266-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.00385
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2964
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.269
ANKRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39644
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.52413
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
PBK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22751
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830721
NUDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632561
BRD-K23467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24066
DNAJC5G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467813
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
BRD-A02481876_Importazole_A549_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MBNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433642
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.964915
ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-A60245366_AS-601245_SKBR3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3663-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
BRD-K59185421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.00811
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
TAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18317
Ventilator-associated lung injury_Lung Tissue_GSE2411	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.91691
Brain Lower Grade Glioma_LGG_TCGA-DH-5140-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61248288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.30245
spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221755
KCNH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632036
GTEX-PWOO-0926-SM-2I3EC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39149
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B2-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYB561A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4235
BET1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5515859__F8	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8253910-mmc9.xlsx-Sheet1-Supplemental_Table_9_ARCHS4_analysis-_z_scores_of_PPAR-family_transcription_factors_in_genes_encoding_DE_Proteins_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
prominent	GeneRIF Biological Term Annotations	1.0	null
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
MET_knockout_252_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.96891
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889096
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82283
AGMAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46645
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
SNUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.38109
Nephritis, Interstitial	CTD Gene-Disease Associations	1.0	1.50473
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923456
CTNNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74083
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04542
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.62713
GSE181966_0_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC15A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54836
18199535-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.842898
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840671
BLOC1S6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520255
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07633
PSMG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605902
BRD-K32259584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.7711
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S341-1526-SM-4AD6K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15582
ASIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53069
GTEX-T5JW-2026-SM-4DM63	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31041
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041474
BRD-K21648400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81781
Fever	CTD Gene-Disease Associations	1.0	1.68337
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PACADD165	DepMap CRISPR Gene Dependency	1.0	4.51711
BRD-K51012353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06051
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Asbestos, Amphibole	CTD Gene-Chemical Interactions	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
NUBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81381
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Protoxylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
GSE210476_11_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IBA57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03843
sulfur compound catabolic process	GO Biological Process Annotations 2025	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH929	CCLE Cell Line Gene CNV Profiles	1.0	2.18293
HT1197	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89514
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DLX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49075
Lateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15714
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81515
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36071
BRD-K24748087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76279
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13445266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04075
Pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.165
Sublaterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63333
BRD-K80779045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36524
GTEX-S33H-0626-SM-2XCBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994708
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.0398
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68518
BRD-K22974051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15611
GSE151364,GSE151366_1_v_2_taf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fmo1	GeneRIF Biological Term Annotations	1.0	null
SASH3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98020844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67109
RERFLCAD2	DepMap CRISPR Gene Dependency	1.0	6.67474
GTEX-POMQ-0126-SM-48TD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98031
IRF6_KO_GDS2359_126_mouse_skin E17.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K62620616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28101
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
sulfur amino acid catabolic process	GO Biological Process Annotations 2023	1.0	null
rostral interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12902
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03396
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5281
BRD-K73497584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57028
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16557
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42966
CLOCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572911
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11514
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919125
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.8996
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
Hypertriglyceridemia	CTD Gene-Disease Associations	1.0	1.60105
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52933
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.975488
CIITA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545723
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47806
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02652
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	0.996274
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01053
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
BRD-K16791544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34093
BRD-K96651591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09867
monooxygenase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859241
Perturb_14686_KO_Sirt3_SRP277814	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CETP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664932
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	1.15461
KMS26	CCLE Cell Line Gene Expression Profiles	1.0	1.70797
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43956
PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-AF_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
EP300	ChEA Transcription Factor Targets	1.0	null
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67408
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791877
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
allelic	GeneRIF Biological Term Annotations	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67701
Lung adenocarcinoma_LUAD_TCGA-69-7978-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
LGALS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407868
Pseudotumor Cerebri	CTD Gene-Disease Associations	1.0	1.12495
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65015
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997795
Corolla tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
BRD-K97943226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0584
BRD-K92022308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00806
SKGII	DepMap CRISPR Gene Dependency	1.0	2.17597
NALM19	CCLE Cell Line Gene Expression Profiles	1.0	2.34347
19325563-Table1b	GeneSigDB Published Gene Signatures	1.0	null
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.30768
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Massive Hepatic Necrosis	CTD Gene-Disease Associations	1.0	1.76481
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.14094
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13555
SARS-CoV MA15_Day7_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.24876
FRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00856502
CLEC4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0119874
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
BRD-K33204113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89365
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874437
BRD-K32896438_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.393
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GCNP_SHH_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115363_3_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5937
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32412
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3442
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2222
KO52	CCLE Cell Line Gene Expression Profiles	1.0	1.95798
BRD-K26760349_HG-9-91-01_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KRR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573935
BRD-K76351135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61126
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALDH6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6401
Cimetidine	HMDB Metabolites of Enzymes	1.0	null
PRKACB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673381
fipexide-3176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K88573743_A443654_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01318
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160017,GSE160022_1_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_6_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hypotension	CTD Gene-Disease Associations	1.0	1.15967
Perturb_17411_KO_Kat7_SRP346205	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K13566078_BMS-345541_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A64523751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57925
isthmic vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13949
Hair follicle bulge	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1134
GTEX-QCQG-0626-SM-48U21	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955268
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06387
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54843
BRD-K14671528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04248
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29921
HCC2429	DepMap CRISPR Gene Dependency	1.0	4.81826
Dermal papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.452
LIPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58598
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Insecticides	CTD Gene-Chemical Interactions	1.0	null
CJM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48951
8MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66794
r7 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33714
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13664
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57677
GTEX-UJHI-0126-SM-4IHLP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
C21orf91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43304
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993056
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26079
ZNF514	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.969
BRD-K12184916_NVP-BEZ235_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GRIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00454871
Fibrosis	CTD Gene-Disease Associations	1.0	2.24264
hsa-miR-4712-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00946863
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.996274
BRD-K08619838_Tremorine dihydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26365
NADPH	HMDB Metabolites of Enzymes	1.0	null
BRD-A29901043_KIN001-127_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SEC61A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49999
SLC49A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20887
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
Hyperemia	CTD Gene-Disease Associations	1.0	1.02821
EEIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86131
GTEX-XMK1-2426-SM-4B66I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0455
risk	GeneRIF Biological Term Annotations	1.0	null
NNT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00329447
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00158
Cevimeline	DrugBank Drug Targets	1.0	null