association	dataset	threshold value	standardized value
BRD-K69520171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2492
BL2595 (PIAS2)	NURSA Protein Complexes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JY-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20823
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37465
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26639
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34171
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.920214
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
GRAMD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.73452
ZNF165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80365
ADGRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891702
synaptic membrane	GO Cellular Component Annotations 2015	1.0	null
SLC49A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20887
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.768647
NOTCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99792
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
benzodiazepine receptor activity	GO Molecular Function Annotations 2025	1.0	null
Respiratory Insufficiency	CTD Gene-Disease Associations	1.0	1.66641
NCIH1781	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02201
Dehydroepiandrosterone	DrugBank Drug Targets	1.0	null
PRKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27098
MRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5376
CASKIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29922
BRD-K81031146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20487
WT1-20215353-NEPHRON-PROGENITOR-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Stupor	CTD Gene-Disease Associations	1.0	1.09857
Essential tremor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5042
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.922826
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35011
hsa-miR-4328	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
TIMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50593
snps	GeneRIF Biological Term Annotations	1.0	null
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16355
[<sup>18</sup>F]fluoroethylflumazenil	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40635
intermediate stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08289
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62995
GPRASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78671
SF767	CCLE Cell Line Gene Expression Profiles	1.0	1.53955
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal thermal nociception	MPO Gene-Phenotype Associations	1.0	null
signaling	GO Biological Process Annotations 2015	1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855243
BRD-K57035236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71237
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63026
ADGRA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98945
alar plate of p2 (alar thalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31994
TTC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9452
Isoflurane	DrugBank Drug Targets	1.0	null
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8266
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.826634
TUBB4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69499
abnormal pain threshold	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FAM219B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77363
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7813
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GABRG3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33396
MFM-223	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47807
Chlordiazepoxide	HMDB Metabolites of Enzymes	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19078
superficial stratum of p2ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03814
Schizoaffective Disorder, Bipolar Type	DisGeNET Gene-Disease Associations	1.0	null
TAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.795
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51141
Cognition Disorders	CTD Gene-Disease Associations	1.0	2.01159
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89987
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
meprylcaine-6123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Propofol	DrugBank Drug Targets	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.053073
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1603
BRD-K07482874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10925
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91934
PRRC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81937
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38149
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3621
PRC1_BMI_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
tretinoin-390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05664
BRD-K72278003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1966
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88771
ZMYND8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13481
B3GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25098
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07345
Fever	CTD Gene-Disease Associations	1.0	1.19113
NUDT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65701
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60384
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829546
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02671
BRD-K48338059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04093
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2302
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8116
PCOLCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51013
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04146
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
transmembrane transporter complex	GO Cellular Component Annotations 2015	1.0	null
SF295	CCLE Cell Line Gene Expression Profiles	1.0	2.02299
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1196
SW982	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Heart Arrest	CTD Gene-Disease Associations	1.0	1.11571
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04048
ramifenazone-2534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Secobarbital	DrugBank Drug Targets	1.0	null
MCTS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80843
GSE137914_4_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H4C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57907
ZNF415	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93936
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32625
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55234
BRD-K45185240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04431
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09076
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
H3K27me3_iPS-15b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3677-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
NCI-H1299	GDSC Cell Line Gene Expression Profiles	1.0	1.57121
Type 2 diabetes	GWAS Catalog SNP-Phenotype Associations	1.0	0.220915
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03936
PMC6870463-Table_7.xlsx-Family_H_LPS-LPS_treatment_of_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Eye-adipocyte	Tabula Sapiens Gene-Cell Associations	1.0	3.33948
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7045-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TACSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77875
hsa-miR-762	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16061
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posttranslational	GeneRIF Biological Term Annotations	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.23793
Bipolar Disorder_Cerebral cortex_GSE12649	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.98303
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.00258
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57458
Ventral posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55491
[<sup>3</sup>H]muscimol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GLOD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03445
TYW5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20929
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38367
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8333
hsa-miR-4492	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	4.45576
GSE68147_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ethanol	CTD Gene-Chemical Interactions	1.0	null
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75574
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46399
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.333218
hsa-miR-526b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ZNF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7203
BRD-K05605336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51119
prefrontal	GeneRIF Biological Term Annotations	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.854414
BRD-K31110422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09829
REEP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39916
Mediodorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55195
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.877721
CDK20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78344
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26203
Furosemide	CTD Gene-Chemical Interactions	1.0	null
Disorders of Excessive Somnolence	CTD Gene-Disease Associations	1.0	1.35502
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13836
FTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53822
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26462
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.2618
CPHXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57806
PHC1	ChEA Transcription Factor Targets	1.0	null
LIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30979
GABRA2	Pathway Commons Protein-Protein Interactions	1.0	null
HARA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NUDT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73439
BRD-K62888534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63037
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.9591
Brain Injuries	CTD Gene-Disease Associations	1.0	1.71317
Perturb_17360_OE_HDAC4_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
number	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Apical dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.257
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.92685
ventral posterior parvicellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.617
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.64708
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
post-traumatic stress disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
SMYD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33329
Olanzapine	DrugBank Drug Targets	1.0	null
COQ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78963
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14777
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35249
wolfram syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.836837
METHAQUALONE	DGIdb Drug Targets 2026	1.0	0.0334167
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
KCTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69071
GPX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83119
HBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60802
Perturb_17276_KO_Uxt_SRP135119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.00435
ZDHHC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98873
hsa-miR-548d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
BRD-K22718400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9002
RPP25L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5441
INO80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02775
PRKCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73376
18812457-Table3	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-3617	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74393
BRD-A03898562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08135
BRD-K93875187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45397
tribenoside-2946	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.300704
MEPROBAMATE	DGIdb Drug Targets 2026	1.0	0.0891111
RGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.77238
hsa-miR-2392	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
Perturb_14838_KO_Klf14_SRP314854	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.0357
aging	GAD High Level Gene-Disease Associations	1.0	0.293278
SNU46	CCLE Cell Line Gene CNV Profiles	1.0	1.74583
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13509
myoclonic-atonic epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
IQSEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97522
ZDHHC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75209
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
HT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78696
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Clobazam	DrugBank Drug Targets	1.0	null
ITPRID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05761
RBL1_KO_GDS1932_739_mouse_Neurospheres	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19197
channel activity	GO Molecular Function Annotations 2015	1.0	null
other	GeneRIF Biological Term Annotations	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3388
hsa-miR-485-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
sirolimus-6180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.847065
SUZ12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34873
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06025
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
inferior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19152
Fastigial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86596
Delayed Emergence from Anesthesia	CTD Gene-Disease Associations	1.0	1.01249
Hematuria	CTD Gene-Disease Associations	1.0	1.05721
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29186
GSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38134
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Neuron spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.529
MTF2	ChEA Transcription Factor Targets	1.0	null
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18412
Secobarbital	HMDB Metabolites of Enzymes	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13098
BRD-K98474331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17509
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3935	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8929
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13093
AGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20013
BRD-K15269548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15941
CSTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49906
NANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0558
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80143
TNFSF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73784
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
DCLRE1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63493
[<sup>3</sup>H]CGS8216	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Sarcoma_SARC_TCGA-HB-A3L4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4427	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
Cocaine abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
DESFLURANE	DGIdb Drug Targets 2026	1.0	0.0172473
Mood Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
MAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74814
Eszopiclone	DrugBank Drug Targets	1.0	null
hsa-miR-181d	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874099
FOXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84888
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899445
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881374
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.33117
NCO2	CCLE Cell Line Gene Expression Profiles	1.0	1.38069
Glutethimide	DrugBank Drug Targets	1.0	null
Autosomal dominant intellectual developmental disorder 41	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
RCOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84112
delta-hexachlorocyclohexane	CTD Gene-Chemical Interactions	1.0	null
LCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76563
BRD-K37532736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08984
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
TBPS	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87803
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962304
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GNE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67782
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43393
ACTR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23993
PROCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16111
TCFL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68842
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77983
Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BABAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96271
RFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37717
Ergoloid mesylate	DrugBank Drug Targets	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97445906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95313
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
valproic acid-1150	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nicotine addiction	KEGG Pathways 2026	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_PHC1_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TECPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20374
DENND4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95117
membrane part	GO Cellular Component Annotations 2015	1.0	null
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.356687
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.849662
hsa-miR-4795-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
BRD-K65320638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96787
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2813
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13654
Tongue epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
PMC7913835__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Butabarbital	DrugBank Drug Targets	1.0	null
gammaaminobutyric	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
kinetic	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3TQ-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72068
LRRC8E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01453
ZNF221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38987
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
GABA-gated chloride ion channel activity	GO Molecular Function Annotations 2023	1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164463_2_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THBD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50735
Syp1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
calcium- and calmodulin-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.076
NCIH684	CCLE Cell Line Gene Expression Profiles	1.0	1.6085
BRD-K03376048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23104
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18064
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35594
truncated	GeneRIF Biological Term Annotations	1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52004
ASAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0888
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.803
BV173	CCLE Cell Line Gene Expression Profiles	1.0	2.13763
RHOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19432
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60719499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74272
Clorazepate	HMDB Metabolites of Enzymes	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dopaminergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.592
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95154
liminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30307
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42863
Neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PMC10785552-13059_2023_3149_MOESM7_ESM.xlsx-RNAseq_HOXA9_rescue-Table_S6_The_DEGs_in_in_RBM5_KO_cells_with_HOXA9_overexpression_relative_to_RBM5_KO_control_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
Psychomotor Agitation	CTD Gene-Disease Associations	1.0	1.12185
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24509
ACIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91029
BRD-K24453679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36711
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.127949
RANBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07114
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.16453
Neurotransmitter-gated ion-channel transmembrane domain	InterPro Predicted Protein Domain Annotations	1.0	null
SMAGP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78798
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_13935_KO_MYT1_SRP187954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
r3 part of lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02734
haloperidol-6203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968492
BRD-K13672060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68045
PMC3376184__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00521
CCDC106	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85516
BRD-K22715231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HT1376	DepMap CRISPR Gene Dependency	1.0	2.24563
BRD-K48389907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66646
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0053
Swine testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
MES-SA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31634
Chloroplast inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.204
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23085
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831943
C6orf141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80187
LIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8098
LRRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04695
heart conduction disease	GWASdb SNP-Disease Associations	1.0	0.275863
RBBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91647
mantle zone of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10747
r4 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33421
Hypothermia	CTD Gene-Disease Associations	1.0	1.42642
Cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.276
gabaars	GeneRIF Biological Term Annotations	1.0	null
Disease of mental health	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
MAP1LC3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39328
CRCGN016_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03607
inner CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64087
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	1.73871
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
geldanamycin-6187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K70856965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.89475
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
insulin resistance	GWASdb SNP-Phenotype Associations	1.0	0.50086
fenbufen-2346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2436
OCILY3	CCLE Cell Line Gene Expression Profiles	1.0	1.3525
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.471
BRD-K16331797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8251
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.179
GABRA6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6393_KO_Ngr1_SRP098816	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35155
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1868
BRD-K39649723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59745
dendrite	GO Cellular Component Annotations 2025	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72609226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55126
Excitatory synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.634
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.39813
RERFLCAD1	CCLE Cell Line Gene CNV Profiles	1.0	2.09205
susceptibility	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84073
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.085
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946372
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.834142
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01407
WT1	ChEA Transcription Factor Targets	1.0	null
NPAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21727
HICS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.571
TDRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44102
FOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50464
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841765
BRD-K39498165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54261
DIAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22831
oxedrine-6156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
prefrontal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235748
Olfactory placode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
RIF1_KD_GDS4943_13_mouse_J1 ESC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SSX2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.97577
alpha1betaxdelta	GeneRIF Biological Term Annotations	1.0	null
CDC42BPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1989
SUZ12	ChEA Transcription Factor Targets	1.0	null
hsa-miR-654-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
OCIAML5	CCLE Cell Line Gene Expression Profiles	1.0	2.65493
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5955
protein-kinase-c	Phosphosite Textmining Biological Term Annotations	1.0	null
Apnea	CTD Gene-Disease Associations	1.0	1.41396
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13093
COL9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07272
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04893
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81693
CAOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
SLC25A27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90897
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3395
AGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27439
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.938
inorganic anion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
Neuronal System	Reactome Pathways 2014	1.0	null
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
hsa-miR-26a	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
symptom	GeneRIF Biological Term Annotations	1.0	null
cii3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12702
inner CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.29774
NAT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87141
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_upregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ7-1326-SM-3MJHO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88745
IFRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30711
TALBUTAL	DGIdb Drug Targets 2026	1.0	0.0802
periventricular stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33573
gamma-aminobutyric acid receptor life cycle pathway	Biocarta Pathways	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29957
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875021
Axon collateral	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.583
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98031
MFE296	DepMap CRISPR Gene Dependency	1.0	3.32193
hsa-miR-33a	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
alpha-ergocryptine-2572	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPMI-2650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K21332842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75081
TGIF2LY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72595
BRD-K45318035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07858
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ebolavirus(EBOV)_6day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80076
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64522
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36336
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6133-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell communication	GO Biological Process Annotations 2015	1.0	null
C6orf132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.84766
ciprofibrate-6138	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K08142337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54702
GSE137914_0_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thalamus, polymodal association cortex related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20968
FAM135A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32185
BRD-K90205159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02103
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.57231
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FIGLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63014
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.44045
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.828984
hsa-miR-4419b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99226
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
subunitcontaining	GeneRIF Biological Term Annotations	1.0	null
Hippocampus minor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074551
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14519
ZNF205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08363
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09714
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neurotransmitter-gated ion-channel ligand-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27717
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0967
hippocampus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868511
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
NOMO-1	GDSC Cell Line Gene Expression Profiles	1.0	2.01887
inhibitory extracellular ligand-gated monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
hsa-miR-4284	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18412
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7451
FLUMAZENIL	DGIdb Drug Targets 2026	1.0	0.0562807
PITPNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10412
BRD-K56274797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62833
SF3A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86295
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87062
hsa-miR-922	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00233
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9055
PMC5054603__F3	PFOCR Pathway Figure Associations 2023	1.0	null
[3H]GABAZINE	DGIdb Drug Targets 2026	1.0	0.0594074
Thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.794
CTCF	ENCODE Transcription Factor Targets	1.0	null
GABRB3	Pathway Commons Protein-Protein Interactions	1.0	null
Hypercholesterolemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K74537725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25008
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
DMRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83248
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14833
GPX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21014
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43603649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26318
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.28098
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.18326
Granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.55
acemetacin-2411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.764
BBIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83871
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.002
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7653
HOXA9_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
single	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47394
A172	BioGPS Cell Line Gene Expression Profiles	1.0	1.21416
BRD-K73834056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01619
confers	GeneRIF Biological Term Annotations	1.0	null
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.587629
hsa-miR-4699-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Terminal bouton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.057
PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14299_KO_Mef2c_SRP057560	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39097
BRD-K81400584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27941
Proximal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
gamma-Aminobutyric Acid	CTD Gene-Chemical Interactions	1.0	null
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934335
BRD-K60192542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3221
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19734887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15476
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09811
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.636743
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mental Retardation	HuGE Navigator Gene-Phenotype Associations	1.0	null
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32422
properties	GeneRIF Biological Term Annotations	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56893290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86685
nicotine	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Flurazepam	DrugBank Drug Targets	1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
fenoprofen-2553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BROMAZEPAM	DGIdb Drug Targets 2026	1.0	0.0509206
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.936344
SMARCA4	ChEA Transcription Factor Targets	1.0	null
CPXCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42886
LN18	BioGPS Cell Line Gene Expression Profiles	1.0	0.837992
MEC1	CCLE Cell Line Gene Expression Profiles	1.0	1.85687
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.174247
Essential Tremor	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942501
BRD-K20028052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68943
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.027
SNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08996
DENND4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57904
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.996127
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.933954
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.365826
SMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69444
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Triazolam	DrugBank Drug Targets	1.0	null
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61828
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71467
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5589-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
alcohol	GeneRIF Biological Term Annotations	1.0	null
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55633
Amoxapine	DrugBank Drug Targets	1.0	null
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73965
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95629
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6624
Hereditary spastic paraplegia 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73854
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47312
Postsynaptic density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.397
16498405-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87865
intermedioposterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25568
BRD-K61278167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.23129
hsa-miR-3929	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
REH	GDSC Cell Line Gene Expression Profiles	1.0	3.60177
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6134-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.86465
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93895
SKCO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65515
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.76
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82114
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SA-A6C2-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICUCULLINE	DGIdb Drug Targets 2026	1.0	0.0763809
PMC6986441__F5	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K90902537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30955
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
MAP1LC3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71337
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82946
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59639
Forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.286
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-500a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
inner CP in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1173
TMEM14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71544
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04512
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.866535
Acute Myeloid Leukemia_LAML_TCGA-AB-2899-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-630	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49437
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.685891
HS729	CCLE Cell Line Gene CNV Profiles	1.0	1.51463
BRD-K29760532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02839
neuronal	GeneRIF Biological Term Annotations	1.0	null
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978283
ZNF501	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56112
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Flurazepam	HMDB Metabolites of Enzymes	1.0	null
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
autosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.797895
olfactory tubercle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.869508
CLPP_KO_GDS4791_108_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
nterminus	GeneRIF Biological Term Annotations	1.0	null
multiple	GeneRIF Biological Term Annotations	1.0	null
abnormality of granulocytes	GWASdb SNP-Phenotype Associations	1.0	0.294353
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Neuroactive ligand signaling	KEGG Pathways 2026	1.0	null
Perturb_17365_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K04498687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60622
Globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56925
SIAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6092
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68463857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1181
PNMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95078
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.871357
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15572
Perturb_3576_KO_Otx2_SRP279863	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.43376
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.38853
Axon hillock	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
HEP3B217	CCLE Cell Line Gene CNV Profiles	1.0	1.65261
BRD-K22071228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02908
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.96526
Autosomal recessive spinocerebellar ataxia 24	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
PIPERIDINE-4-SULPHONIC ACID	DGIdb Drug Targets 2026	1.0	0.0594074
Clonazepam	DrugBank Drug Targets	1.0	null
CAB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78542
hsa-miR-892b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
cell part	GO Cellular Component Annotations 2015	1.0	null
Schizoaffective disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Zn<sup>2+</sup>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
knockout	GeneRIF Biological Term Annotations	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC9237085-41467_2022_31238_MOESM4_ESM.xlsx-Table_4_MYC_BC_signature-HGNC_symbol_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21119
alpha4	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06237859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53051
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43918582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24041
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88826
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE106130_0_v_1_grhl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.43024
BRD-K64509231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47433
BRD-K45893504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40708
sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.170561
TIMM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2015
Transmission across Chemical Synapses	Reactome Pathways 2014	1.0	null
RNFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12595
dorsal tier of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41094
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00662
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27464
SKIDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02125
familial	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K59657378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04402
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.7222
KLC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84727
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2473
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45019
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
synaptic transmission, GABAergic	GO Biological Process Annotations 2025	1.0	null
Superior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
PTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87933
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3011
hsa-miR-489	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
alimemazine-2736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Talbutal	HMDB Metabolites of Enzymes	1.0	null
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ARL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33745
Lung adenocarcinoma_LUAD_TCGA-75-7030-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68916730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38112
Neocortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.388
PNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8152
CRCGN013_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21767
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.347
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72602
ANKRD49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84696
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21974
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848752
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.20811
KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53646
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17584
CHLORDIAZEPOXIDE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.0334167
Flunitrazepam	DrugBank Drug Targets	1.0	null
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.27485
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.01394
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881725
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63265
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC2998	DepMap CRISPR Gene Dependency	1.0	4.22388
gamma-aminobutyric acid signaling pathway	GO Biological Process Annotations 2015	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00721
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47713
Epilepsy	CTD Gene-Disease Associations	1.0	1.49686
Perturb_14532_KO_Ptf1a/Nr5a2_SRP111204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51743
Transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.618
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichostatin A-1785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ion-channel-gating	Phosphosite Textmining Biological Term Annotations	1.0	null
hsa-miR-33b	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.997
Hyperemia	CTD Gene-Disease Associations	1.0	1.13075
SIRT3_KO_GDS4058_454_mouse_BROWN ADIPOSE TISSUE	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.81585
SNAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55154
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39772
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.087376
oxolamine-3006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
central nervous system development	GO Biological Process Annotations 2015	1.0	null
BRD-K18688395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22232
ARHGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37029
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83948
Perturb_3822_OE_Hras_SRP342740	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-3145-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
17483317-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61418
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0083
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60087
FOXP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.00362
GTEx BloodVessel 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	7.52095
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3133	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1954	CCLE Cell Line Gene CNV Profiles	1.0	1.9473
BRD-K98510376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36823
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.82439
GTEX-S32W-0526-SM-4AD6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864139
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78688
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35547
chemical synaptic transmission	GO Biological Process Annotations 2025	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.983717
BRD-K02362691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56063
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62768
Meprobamate	HMDB Metabolites of Enzymes	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08195
[3H]MUSCIMOL	DGIdb Drug Targets 2026	1.0	0.0594074
NCI-H441	COSMIC Cell Line Gene Mutation Profiles	1.0	null
effects	GeneRIF Biological Term Annotations	1.0	null
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNAJC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13568
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar nuclei of CbV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80836
16498405-TableS8	GeneSigDB Published Gene Signatures	1.0	null
RERFGC1B	DepMap CRISPR Gene Dependency	1.0	6.03507
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.28985
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0945
dyskinesia, drug-induced;	GAD Gene-Disease Associations	1.0	null
deficient	GeneRIF Biological Term Annotations	1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EC-GI-10	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.83684
Mental Deterioration	DisGeNET Gene-Phenotype Associations	1.0	null
hsa-miR-4662a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Atrioventricular Block	CTD Gene-Disease Associations	1.0	1.21823
Juvenile absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881821
MSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17213
famprofazone-6029	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K28467941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64439
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.74882
EGFL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09144
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76163
Ventricular Dysfunction, Left	CTD Gene-Disease Associations	1.0	1.29688
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73559
BRD-A20018680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30187
Pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CEP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61051
BRD-K72050226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55782
Perturb_14524_KO_LRHt_SRP009598	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.39706
GSE210580_4_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61504
GSE239541_8_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
Tic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.208
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06845
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00288
hsa-miR-3650	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
FLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70456
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22632
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13502
GTEX-OOBJ-3026-SM-3NB1D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932434
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.019
TAPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29185
hsa-miR-150	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
precommissural pretectal domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08954
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
CFAP410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03857
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96425
Movement Disorders	CTD Gene-Disease Associations	1.0	1.72779
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.66253
dependence	GeneRIF Biological Term Annotations	1.0	null
KLE	DepMap CRISPR Gene Dependency	1.0	3.15465
AIFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61421
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23657
essential tremor	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.778204
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896341
betamethasone-dipropionate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77342
CRCGN015_HEPG2_48H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15852
substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.18238
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21707
697	DepMap CRISPR Gene Dependency	1.0	2.36777
Siphon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6863-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24426
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.488276
BRD-K64135153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95158
Diazepam	DrugBank Drug Targets	1.0	null
BRD-K10011427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23872
LYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17297
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57931
ICE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48102
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K28314528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10722
SKN3	DepMap CRISPR Gene Dependency	1.0	5.96913
Plasma membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
LMX1B_KO_GDS3320_57_mouse_embryonic (e11.5) proximal hindlimb bud tissues	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2716-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15579
NDUFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58059
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Aprobarbital	HMDB Metabolites of Enzymes	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.79606
Iron uptake and transport(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.376
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-586	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
ADIPIPLON	DGIdb Drug Targets 2026	1.0	0.0562807
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28033
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04724
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55642
P2RX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66904
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06273
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37131
ZSWIM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38712
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846767
BRD-K05734090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52394
TMEM165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52885
C3orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79613
RPMI-6666	GDSC Cell Line Gene Expression Profiles	1.0	1.69458
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0653
BRD-K67609710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01647
r1 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08412
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843749
hsa-miR-4733-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Small_Intestine-intestinal tuft cell	Tabula Sapiens Gene-Cell Associations	1.0	1.01158
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05198
451LU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25054
ABP-700	DGIdb Drug Targets 2026	1.0	0.0334167
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4322	TargetScan Predicted Conserved microRNA Targets	1.0	0.029271
BRD-K58932103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12799
BRD-K18189580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38637
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1011
hsa-miR-3662	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	1.19386
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.890137
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.013
GTEx BloodVessel 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	9.81899
atropine-1768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
Epilepsy with generalized tonic-clonic seizures	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
BUTALBITAL	DGIdb Drug Targets 2026	1.0	0.0802
PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-Proximal_Tubule_Enriched_Genes_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PYCR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01503
COL4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11009
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09584
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.62455
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.944015
ORC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29707
pepstatin-1328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-641	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
behavior	GeneRIF Biological Term Annotations	1.0	null
GABRA4-related developmental and epileptic encephalopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
BRD-K79619334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0065
Melancholic depression	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88446
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72756
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04492
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
chloride transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
ZNF736	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66097
luteolin-6658	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78149
hsa-miR-4764-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
anterior pretectal nucleus, dorsal core part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35632
inner CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863076
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45206
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00433
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882726
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.27765
Subpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal GABA-mediated receptor currents	MGI Mouse Phenotype Associations 2023	1.0	null
Ethchlorvynol	DrugBank Drug Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8635-11A-01R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIERCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16973
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959395
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	SynGO Synaptic Gene Annotations	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Clonazepam	HMDB Metabolites of Enzymes	1.0	null
SN12C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sevoflurane	DrugBank Drug Targets	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8128
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5937
delta	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4775	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62906
Perturb_13976_KO_H3f3a/H3f3b_ERP109384	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.1926
Medial septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
BRD-K60848736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2608
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3859
Memory Disorders	CTD Gene-Disease Associations	1.0	1.92172
Dendritic spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.53
Headache	CTD Gene-Disease Associations	1.0	1.13552
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
C6orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61602
signal transduction	GO Biological Process Annotations 2015	1.0	null
chloride transport	GO Biological Process Annotations 2023	1.0	null
BRD-K63436783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04711
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH226	DepMap CRISPR Gene Dependency	1.0	9.0789
CLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69113
H3K27me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PFSK1	DepMap CRISPR Gene Dependency	1.0	7.05689
BRD-K18515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66184
OFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32739
SNB75	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.950235
GSE174383_1_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.34829
TBPS	DGIdb Drug Targets 2026	1.0	0.0281403
hsa-miR-516b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.883628
BRD-K32906083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45324
TRICLOFOS SODIUM	DGIdb Drug Targets 2026	1.0	0.0334167
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09541
PMC8810962__F4	PFOCR Pathway Figure Associations 2024	1.0	null
DEDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50013
endogenous	GeneRIF Biological Term Annotations	1.0	null
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07577
MT-CO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65857
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.9699
H2AL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28258
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35165
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30373
Rhabdomyolysis	CTD Gene-Disease Associations	1.0	1.07022
PAGOCLONE	DGIdb Drug Targets 2026	1.0	0.0334167
REH	CCLE Cell Line Gene Expression Profiles	1.0	3.40763
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24574
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
ZURANOLONE	DGIdb Drug Targets 2026	1.0	0.0334167
abnormal gaba-mediated receptor currents	MPO Gene-Phenotype Associations	1.0	null
THIOPENTAL SODIUM	DGIdb Drug Targets 2026	1.0	0.031451
N4BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44155
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
CLTC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36805
Chlorine	HMDB Metabolites of Enzymes	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36044
GIPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77349
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40936
NCI-H508	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OccipitalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.163
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35726223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16885
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00834
Barbituric acid derivative	DrugBank Drug Targets	1.0	null
developmental process	GO Biological Process Annotations 2015	1.0	null
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.742057
Tachycardia, Ventricular	CTD Gene-Disease Associations	1.0	1.07128
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.46041
schizophrenia	GeneRIF Biological Term Annotations	1.0	null
PMC6986441__F5	PFOCR Pathway Figure Associations 2023	1.0	null
Prader-Willi syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0053
BRD-K33956641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57069
Criduchat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51889
Postcentral gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.217
Lung adenocarcinoma_LUAD_TCGA-78-7158-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64743
KRAS.600.LUNG.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27281
ZNF668	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85367
LASV_FML29_8hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.82068
SNU1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53414
Postsynapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
DARIGABAT	DGIdb Drug Targets 2026	1.0	0.0334167
TAGLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64263
GPRASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60899
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46986
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Alcohol dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.32
neurons	Phosphosite Textmining Biological Term Annotations	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.25202
phenotype	GeneRIF Biological Term Annotations	1.0	null
Clobazam	HMDB Metabolites of Enzymes	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60625
hsa-miR-548ac	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
inner CP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06678
[<sup>11</sup>C]flumazenil	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
PPM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21869
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66308
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5401
Rectum adenocarcinoma_READ_TCGA-AH-6644-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18537972-TableS2	GeneSigDB Published Gene Signatures	1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.824431
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38978
GEM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39144
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99311
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cell junction	GO Cellular Component Annotations 2015	1.0	null
nicotine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.40483
hsa-miR-3140-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
BRD-K81119027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33457
YAPC	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57823
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
GSE190316,GSE190324_5_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SART3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14623
KDM4A	ENCODE Transcription Factor Targets	1.0	null
BRD-K63468420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34102
CRCGN008_HEPG2_24H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08205
each	GeneRIF Biological Term Annotations	1.0	null
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46974
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05699155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47897
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02321
PRKCG	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A8D1-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22365
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8997_KO_KDM6A_SRP309312	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.86572
TRIM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36486
isoguvacine	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
EIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53004
single-organism transport	GO Biological Process Annotations 2015	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58113
MRPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08904
20388125-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CEP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04624
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903217
dendrite membrane	GO Cellular Component Annotations 2025	1.0	null
BAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05322
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.198
abnormal neutrophil cell number	GWASdb SNP-Phenotype Associations	1.0	0.590389
gaba receptor activity	GO Molecular Function Annotations 2015	1.0	null
COPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00017
GOLGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12307
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89471
CRCGN016_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5627
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04997
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01319
ENPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30859
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78315404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68717
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17638
CRLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68542
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044889
transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.005336
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18104
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02366
FGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32226
obesity	GWASdb SNP-Phenotype Associations	1.0	0.849662
ventral linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88376
SUZ12-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15828
intermediate stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35688
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
ZMAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30338
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40612
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24786
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.943954
GABA-A receptor complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PCMTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66235
TECPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14346
Lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03869
Gamma-aminobutyric acid A receptor/Glycine receptor alpha	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2694
dorsal subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0345
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841765
decreased thermal nociceptive threshold	MGI Mouse Phenotype Associations 2023	1.0	null
S1PR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71692
CRCGN015_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29904
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86472
EFR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53318
hsa-miR-4781-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48009
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Parafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67568
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831531
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07397
camp	Phosphosite Textmining Biological Term Annotations	1.0	null
NCIH1437	DepMap CRISPR Gene Dependency	1.0	2.14308
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0506
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4052
RASSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04097
NDUFA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66123
Axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.949
RASSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17322
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20402
Parietal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.282
chr4_46998867_A_AC_b38	GTEx eQTL 2025	1.0	1.03933
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
piperidine-4-sulphonic acid	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
harman-2150	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30132
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32766
ABTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98082
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90076
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHRAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3421
hsa-miR-548z	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
dentate gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.507849
bipolar disorder	GAD Gene-Disease Associations	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intermediate stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0175
CAPN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5531
r3 part of parvicellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07852
contribute	GeneRIF Biological Term Annotations	1.0	null
ZCCHC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99069
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21962
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10301
impaired behavioral response to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
aklomide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07815
BRD-K24047785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20032
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.924586
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50456
intermediate stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17115
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.856489
hsa-miR-3653	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44451
DESI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30613
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8906
modulate	GeneRIF Biological Term Annotations	1.0	null
Prestwick-864-2994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2599
monensin-2580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35434
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
[<sup>35</sup>S]TBPS	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Triazolam	HMDB Metabolites of Enzymes	1.0	null
KATNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04548
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915069
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZCCHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47826
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4954
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39591
BRD-K88542817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40606
Substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.458
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU16	DepMap CRISPR Gene Dependency	1.0	2.87973
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.561769
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.898532
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03412
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.997104
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31056
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13258
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59224
APP	Pathway Commons Protein-Protein Interactions	1.0	null
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.778
Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.8248
ethnic	GeneRIF Biological Term Annotations	1.0	null
KDM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65591
localization	GO Biological Process Annotations 2015	1.0	null
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54098
Subparafascicular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10616
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Clorazepate	DrugBank Drug Targets	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1715
Ionotropic glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.635
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855654
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5672-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Coma	CTD Gene-Disease Associations	1.0	1.72863
GOLGA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69522
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.713369
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Seizures	CTD Gene-Disease Associations	1.0	2.13392
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30642
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116299_6_v_1_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SYNRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88033
GSE131887_1_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60847609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78812
Bradycardia	CTD Gene-Disease Associations	1.0	1.43021
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.413912
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.17167
Pregnanolone	CTD Gene-Chemical Interactions	1.0	null
MRPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43855
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04981
periventricular stratum of p2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3041
hsa-miR-618	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95629
prasterone-3097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
transporter complex	GO Cellular Component Annotations 2015	1.0	null
BRD-K05475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.514
polypeptide	GeneRIF Biological Term Annotations	1.0	null
SPIN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18738
RNF2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FZD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73141
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2333
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59848
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71939
BRD-K62000282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03582
DCTPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6971
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-RELB_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6365-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46778
BRD-K05645536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0514
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18803
BRD-K28982281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.78441
BRD-K18519876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81268
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45461
BRD-K85917058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19755
SKM1	CCLE Cell Line Gene Expression Profiles	1.0	2.40871
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
hsa-miR-181c	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
RNF2-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K18573205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94501
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36241
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ACSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.096
solasodine-2170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.06406
hsa-miR-188-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
DCXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48923
hsa-miR-3154	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
WDR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73587
NUGC2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.16322
GATA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18698
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61194
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZSCAN5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53968
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883248
BRD-K18594025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52752
lateral (parvicellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60025
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26759
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMCO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70044
BRD-K14813771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52208
BRD-K51779559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00274
CIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63529
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nabumetone-3108	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.908201
BRD-K47143916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64799
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44471
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
acetylcholine-gated channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
ZNF649	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04479
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830607
KYSE-150	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6499
contributing	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4679	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
only	GeneRIF Biological Term Annotations	1.0	null
mRNA_MYOD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PMC9584741__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Schizoaffective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.76
ING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61736
Streptococcal tonsillitis_Tonsillar Lymphoid Tissue_GSE11494	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-3.94872
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85447
PICROTOXIN	DGIdb Drug Targets 2026	1.0	0.0232464
Hallucinations	CTD Gene-Disease Associations	1.0	1.31506
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930082
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12671
GTF2H5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76924
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79606
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04397
muscimol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K71919612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.75758
Adrenocortical carcinoma_ACC_TCGA-OR-A5JY-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.57
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79251
BRD-K47175449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60949
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19078
Nitrazepam	HMDB Metabolites of Enzymes	1.0	null
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94694
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.277
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.040597
SNPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5406
MTLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.509
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1963	COSMIC Cell Line Gene Mutation Profiles	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
16498405-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-11A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.84811
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02278
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLHL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50175
PTPRU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63001
Interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.037
hsa-miR-4265	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24788
ENAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51182
potentially	GeneRIF Biological Term Annotations	1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02462
GSK3B_KD_GDS4305_181_human_MOLM-14 myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881725
SP110	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37212
MET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98701
chloride channel activity	GO Molecular Function Annotations 2015	1.0	null
Serotonin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.172
moracizine-2959	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.634
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
mRNA_RXRA_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1754
mice	GeneRIF Biological Term Annotations	1.0	null
TMEM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86836
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041486
Aprobarbital	DrugBank Drug Targets	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.5464
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.7874
hsa-miR-4424	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
NRN1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66505
hsa-miR-3180-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
PIK3R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86333
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27169
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0653
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.357
BDCM	CCLE Cell Line Gene Expression Profiles	1.0	1.43356
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.21544
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7742-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A64985224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12323
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.809216
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.976902
groups	GeneRIF Biological Term Annotations	1.0	null
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88932
scopolamine N-oxide-2262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.69513
SETDB1-19884255-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837509
BRD-K50859531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42432
BRD-K44492160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73442
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23575
hsa-miR-186	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
cloperastine-2549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39696
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67904
hsa-miR-520a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GSE174383_1_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bulimia	HuGE Navigator Gene-Phenotype Associations	1.0	null
GABA receptor complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lorazepam	CTD Gene-Chemical Interactions	1.0	null
ETIFOXINE	DGIdb Drug Targets 2026	1.0	0.0334167
benzodiazepine receptor activity	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-4441	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dentate gyrus HICAP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4084
brain	Phosphosite Textmining Biological Term Annotations	1.0	null
C2orf69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97829
UBE2J2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47384
GABRA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RERFLCAD2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63453
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BUTABARBITAL SODIUM	DGIdb Drug Targets 2026	1.0	0.0334167
r6 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02022
BRD-K22599787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25146
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852676
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12652
BRD-K43029808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24399
BRD-A01717111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25483
profound	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3915	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ZNF676	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25942
HSPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32775
MRPL45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95001
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6030-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93332
SEPTIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44267
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
DDX60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28435
GABA receptor signaling	WikiPathways Pathways 2024	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0942
CLCN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71111
NCIH1299	CCLE Cell Line Gene Expression Profiles	1.0	1.79978
limit	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75762
isosorbide-2183	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
establishment of localization	GO Biological Process Annotations 2015	1.0	null
ZNF570	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67606
GSE190316,GSE190324_6_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-548aj	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
BRD-K04544693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55818
cos-cells	Phosphosite Textmining Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.59024
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86141
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44856
hsa-miR-525-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Hyperalgesia	CTD Gene-Disease Associations	1.0	1.71193
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.870623
gabexate-2937	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03896
BRD-K26399271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13253
CLN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.20315
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44931
KLK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77323
periventricular stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12052
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0293
PMC4445818-13062_2015_58_MOESM2_ESM.xlsx-NSCL_Adjacency_Lists-Gene_symmbol_for_Protein_B_NHLH1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4296	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
SYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02541
confirmed	GeneRIF Biological Term Annotations	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
ABCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61281
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.720124
Restless Legs Syndrome	DisGeNET Gene-Disease Associations	1.0	null
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11249
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90183
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Muscle Weakness	CTD Gene-Disease Associations	1.0	1.02746
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80441
SELENOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8321
MLLT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89275
TRIM56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86008
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08475
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZN2+	DGIdb Drug Targets 2026	1.0	0.024303
ZNF234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20234
Vestibular nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2104
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NR1H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.65388
mRNA_SALL4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GABA receptor activation	Reactome Pathways 2024	1.0	null
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824891
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855243
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.956313
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06113
hsa-miR-1260b	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
BRD-K13922961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18577
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.4
neuronal	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879743
BRD-K52194153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13755
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K28820796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40322
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AP5S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56059
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.881425
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95329
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.852527
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49081
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GABAergic synapse	KEGG Pathways 2026	1.0	null
ZNF257	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97295
etiology	GeneRIF Biological Term Annotations	1.0	null
Metharbital	DrugBank Drug Targets	1.0	null
Transmission across Chemical Synapses	Reactome Pathways 2024	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_Targetome-Genes_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pyramidal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.786
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
preference	GeneRIF Biological Term Annotations	1.0	null
Gamma-aminobutyric-acid A receptor, alpha 4 subunit	InterPro Predicted Protein Domain Annotations	1.0	null
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vestibular nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844477
Pruritus	CTD Gene-Disease Associations	1.0	1.11431
hsa-miR-1305	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.892296
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.105968
KCND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49919
NCKAP5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86744
Suprageniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24864
Premenstrual Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
overnutrition	GWASdb SNP-Disease Associations	1.0	0.4704
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12463
Temazepam	HMDB Metabolites of Enzymes	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
METHOXYFLURANE	DGIdb Drug Targets 2026	1.0	0.0254603
BRD-K14193598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11658
ETOMIDATE	DGIdb Drug Targets 2026	1.0	0.0943529
PLD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95295
mantle zone of p2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03287
integral component of postsynaptic specialization membrane	SynGO Synaptic Gene Annotations	1.0	null
PSMD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59942
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
LIMK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.984
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33103
CRCGN015_MCF10A.WT.HP_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01484
Raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.145
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Lorazepam	HMDB Metabolites of Enzymes	1.0	null
M059K	CCLE Cell Line Gene Expression Profiles	1.0	1.8972
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3878
metabolic	Phosphosite Textmining Biological Term Annotations	1.0	null
Pentobarbital	DrugBank Drug Targets	1.0	null
TAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56532
GSE150032,GSE181873_3_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of neutrophils	GWASdb SNP-Phenotype Associations	1.0	0.378591
PREP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98091
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92611
PAGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95734
Conduct disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49521
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
immune system disease	GWASdb SNP-Disease Associations	1.0	0.053599
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ARPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96534
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
oxamic acid-439	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.984667
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.27054
ZCCHC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12693
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1094
GSE205070_1_v_4_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.54159
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.844467
FGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27376
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.068343
ZNF200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56968
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24343968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18658
NR2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88045
NAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22726
Estazolam	DrugBank Drug Targets	1.0	null
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.29051
BRD-K11630986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37833
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22847
interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.717061
hsa-miR-3671	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Synaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.712
Limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.221
WDR82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43672
BRD-K32723442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62304
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.869
Prestwick-1084-6125	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABA-ergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.249
monoatomic anion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13797
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.20654
SLC50A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70242
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865483
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01649
chloride channel complex	GO Cellular Component Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3586
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1383
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26223
hsa-miR-181a	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
ARHGEF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48697
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.2034
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.02821
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
ES6	GDSC Cell Line Gene Expression Profiles	1.0	2.35788
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1406
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14782_KO_Kansl3_SRP225948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.8874
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19078
BRD-K41202439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06053
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01562
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08954
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01518
tachycardia	GWASdb SNP-Phenotype Associations	1.0	0.443881
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54668
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.003
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.803
EHEB	CCLE Cell Line Gene Expression Profiles	1.0	2.25277
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Chloroplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
Fatty Liver	CTD Gene-Disease Associations	1.0	1.01512
CFAP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43278
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NMDA selective glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5529
BRD-K20600965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36022
BRD-K00698280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17626
GYG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83873
LOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6972
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
synapse assembly	GO Biological Process Annotations 2025	1.0	null
Perturb_10638_Mut_Cryaa_SRP104440	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.4519
RNASE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37727
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.937328
BRD-K27638063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44617
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.878342
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24697
Fragile X syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
Perturb_9244_KD_ENL_SRP074134	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.35822
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.97753
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988706
ATR_knockdown_140_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.35795
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03937692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1753
amiprilose-3000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Inhibitory synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.747
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.295
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06273
MEPHOBARBITAL	DGIdb Drug Targets 2026	1.0	0.0891111
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
single-organism process	GO Biological Process Annotations 2015	1.0	null
HHIPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85888
butyl hydroxybenzoate-3069	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K89532826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51036
BRD-K56939159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00658
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83252
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83361
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8317-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
THTPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69602
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C2BBe1	GDSC Cell Line Gene Expression Profiles	1.0	1.52487
Bipolar Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Temazepam	DrugBank Drug Targets	1.0	null
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37975
H3K27me3_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5691-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2405	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42256
NCI-H510A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.18434
hsa-miR-4502	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
DNAJC30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68661
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2836
Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.410793
PSMD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2848
Adrenal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.35125
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.03534
COG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63687
NCIH1339	CCLE Cell Line Gene CNV Profiles	1.0	1.51335
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75372
BRD-K16976282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.555
TMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74786
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nd7/23	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35688
SHPRH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01081
ligand-gated monoatomic anion channel activity	GO Molecular Function Annotations 2023	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834172
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.15655
Postoperative Nausea and Vomiting	CTD Gene-Disease Associations	1.0	1.28672
L3MBTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85974
INAVA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80292
mantle zone of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2339
Cerebellar nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.795
MCM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05929
IMEPITOIN	DGIdb Drug Targets 2026	1.0	0.0334167
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	1.0	1.47377
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
chloride transmembrane transport	GO Biological Process Annotations 2023	1.0	null
ELOVL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91424
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943277
synaptic membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oxyphenbutazone-6160	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.10838
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29289
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.307
BRD-K13852343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49047
ChIP_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03865
hsa-miR-628-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Methyprylon	DrugBank Drug Targets	1.0	null
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03569
PCDHGC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49595
ALPRAZOLAM	DGIdb Drug Targets 2026	1.0	0.0534667
postsynaptic membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03985
Perturb_15828_OE_Nrf2_SRP291726	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.10523
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cerebral cortical neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.555274
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01466
BRD-K49745983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06239
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34603
scopolamine-3018	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.259
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.00116
BRD-K09972656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5602
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2847
r1 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10685
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831943
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
phenyl biguanide-22	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RETSAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29811
Neuron to neuron synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.433
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.38345
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59548
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0184
CLPP_KO_GDS4791_543_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CDK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79561
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6082
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.15342
COLO-205	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thiopental	HMDB Metabolites of Enzymes	1.0	null
Topiramate	DrugBank Drug Targets	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
[35S]TBPS	DGIdb Drug Targets 2026	1.0	0.0891111
ZFP36L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55757
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78699
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59613
mBDNF and proBDNF regulation of GABA neurotransmission	WikiPathways Pathways 2024	1.0	null
GABRB2	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065173
huh-7	BioGPS Cell Line Gene Expression Profiles	1.0	1.79985
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.95435
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0104
Schizophrenia	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947239
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22182
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01308
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20684
A-VN-1203-2004(H5N1)_Day4-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.8979
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
THIAMYLAL SODIUM	DGIdb Drug Targets 2026	1.0	0.031451
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1886
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.5716
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930995
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35547
BRD-K35799753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29713
BRD-K64567083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51227
ENFLURANE	DGIdb Drug Targets 2026	1.0	0.0172473
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38829
EHEB	GDSC Cell Line Gene Expression Profiles	1.0	1.95558
ACSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5794
MACROH2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45983
BUTABARBITAL	DGIdb Drug Targets 2026	1.0	0.106933
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.971396
NCIH2126	DepMap CRISPR Gene Dependency	1.0	2.52316
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38067
BRD-K54622858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48491
Prostate adenocarcinoma_PRAD_TCGA-HI-7168-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78493876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23495
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06025
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.93187
DCAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.16983
CUTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00712
BRD-K16109630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08537
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8638-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08438266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39465
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	2.92943
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00945
Sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.347
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91702
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924892
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
mantle zone of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26364
central lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8217
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11107
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.323486
C5orf22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91183
complete	GeneRIF Biological Term Annotations	1.0	null
BRD-K33960497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21796
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24818
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NKX2-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62826
BRD-K35639494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3118
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7184
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.78606
conditioned	GeneRIF Biological Term Annotations	1.0	null
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3389
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01015
Prostate adenocarcinoma_PRAD_TCGA-G9-6370-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22227
PRDM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7872
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABOXADOL	DGIdb Drug Targets 2026	1.0	0.0943529
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60035
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3985
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.34207
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
desoxycortone-3099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
LRRC41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47236
hsa-miR-3909	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
placenta	HPA Tissue Gene Expression Profiles	1.0	0.889023
SHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15462
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25305
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33351
synapse part	GO Cellular Component Annotations 2015	1.0	null
BRD-K08311368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35509
ioversol-3026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K87781745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17521
Mediodorsal nucleus of the thalamus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58856
fludrocortisone-281	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H295R cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11102
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.746144
regulation of response to drug	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.852735
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863382
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95927760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16406
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
ESZOPICLONE	DGIdb Drug Targets 2026	1.0	0.031451
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27313
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43739
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A78125048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86291
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-2474	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38273
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855243
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9434
HDAC2	ENCODE Transcription Factor Targets	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-3026-SM-3NB1G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903545
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35271
AMME complex	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
PMC3376184__F3	PFOCR Pathway Figure Associations 2023	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.860521
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16934
Perturb_17228_KO_lincBrn1b_SRP028547	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.72976
TC-YIK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.1039
FREY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22373
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.085
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HARA	CCLE Cell Line Gene CNV Profiles	1.0	1.76918
BRD-K09395335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3604
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79302
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57146
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41049
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60935
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cocaine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
CHTF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76378
EIF2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74606
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRGBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21312
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11625982-AJH-100-10-s001.pdf-9-ETS1_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CLOBAZAM	DGIdb Drug Targets 2026	1.0	0.0729091
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24621
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19881
MINPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15663
Stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3682
BRD-K30121969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67878
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
GLS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8739
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.91569
NCOA2_KO_GDS4785_172_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956133
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.66363
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.021
PHF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69601
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49253
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.89197
DGAT1	Pathway Commons Protein-Protein Interactions	1.0	null
OCINAPLON	DGIdb Drug Targets 2026	1.0	0.0281403
BRD-K18316646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23387
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25989
H3K27me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3156-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.006367
BRD-K36170758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16075
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
ZOPICLONE	DGIdb Drug Targets 2026	1.0	0.0534667
early	GeneRIF Biological Term Annotations	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.036534
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17401
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VPS4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39018
OXAZEPAM	DGIdb Drug Targets 2026	1.0	0.0616923
Perturb_13905_KD_DAZAP1_SRP102807	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.73587
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	74.8092
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33760911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20291
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
extending	GeneRIF Biological Term Annotations	1.0	null
place	GeneRIF Biological Term Annotations	1.0	null
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29777
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.352461
chloride channel activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60993
Perturb_4180_KO_Tsc1_SRP279018	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.54584
KRAS.LUNG.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CRCGN014_HEPG2_3H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14689
Neurotransmitter receptors and postsynaptic signal transmission	Reactome Pathways 2024	1.0	null
ZSCAN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67879
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72808
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68416
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
anterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21891
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
SKHEP1	DepMap CRISPR Gene Dependency	1.0	2.25389
CRCGN008_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9798
Essential Tremor	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22093396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35462
Granular insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
Cerebellar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73343
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24793
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.714818
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
gabra4	GeneRIF Biological Term Annotations	1.0	null
neurotransmitter receptor activity	GO Molecular Function Annotations 2015	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09316
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14492
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31879
OXSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83604
BRD-K35788497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25293
Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15373812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85475
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Ventral globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.991
PMC8755441-mmc3.xlsx-IRF7-Up-SUZ12_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21432
NCIH1299	CCLE Cell Line Gene CNV Profiles	1.0	2.84994
GSE145323,GSE145324_1_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
BRD-K14117311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37845
BRD-K17060750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17072
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914842
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12085
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.292975
inorganic anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40452322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99097
Dentate gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.898
NCIH1836	CCLE Cell Line Gene CNV Profiles	1.0	2.00559
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4607
CRCGN014_HEPG2_3H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56226
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.494918
PMC9405677__F18	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-4680-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
SEVOFLURANE	DGIdb Drug Targets 2026	1.0	0.0144504
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29217
Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	Reactome Pathways 2014	1.0	null
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.58968
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18145
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0643
COG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9471
impaired behavioral response to xenobiotic	MGI Mouse Phenotype Associations 2023	1.0	null
MM383	DepMap CRISPR Gene Dependency	1.0	6.41324
gaba-a receptor activity	GO Molecular Function Annotations 2015	1.0	null
Dyskinesia, Drug-Induced	HuGE Navigator Gene-Phenotype Associations	1.0	null
lateral subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3481
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913648
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOP-92	COSMIC Cell Line Gene Mutation Profiles	1.0	null
extracellular ligand-gated monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K23123734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15548
BRD-K15273135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08793
Perturb_14601_KO_ASAP2_SRP258574	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80528
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.4068
GLRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87308
intermediate tier of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52645
BRD-K26024910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20169
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Thiopental	DrugBank Drug Targets	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
Prelimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
Desflurane	DrugBank Drug Targets	1.0	null
intracellular	GeneRIF Biological Term Annotations	1.0	null
pharmacogenomic	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15774
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09227140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70449
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37903
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95917
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.36554
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7276
Withdrawal disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
D-336MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Angelman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1943
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.295739
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1518
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10494
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K59560948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26649
SALE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5738
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MEAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36626
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amnesia, Anterograde	CTD Gene-Disease Associations	1.0	1.61365
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Catalepsy	CTD Gene-Disease Associations	1.0	1.57759
BRD-K78789413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1389
MTERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07512
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25678
LINGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02378
Intracranial Hypertension	CTD Gene-Disease Associations	1.0	1.11046
Perirhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949543
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.915482
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27137352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61542
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69668461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02559
L363	CCLE Cell Line Gene Expression Profiles	1.0	1.99329
iron-sulfur cluster transfer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
Glutamatergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.769
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41709602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72832
steroid5alphareductase	GeneRIF Biological Term Annotations	1.0	null
suggesting	GeneRIF Biological Term Annotations	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36506
Somatodendritic compartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
hsa-miR-618	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
mantle zone of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0447
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.871451
r6 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11068
Heptabarbital	DrugBank Drug Targets	1.0	null
trichostatin A-2721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57239
RBM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30643
ARMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20539
PHC1-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
trichostatin A-2672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12297505-41598_2025_11704_MOESM4_ESM.xlsx-table_s4_veen-GSE16011_AND_TCGA-GBMLGG_NOT_Human_kinases_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61912055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15475
bephenium hydroxynaphthoate-3089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
endoplasmic	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.642
RHOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25274
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49007
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.86096
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.88445
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29219
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19253
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pkc	Phosphosite Textmining Biological Term Annotations	1.0	null
KMS34	DepMap CRISPR Gene Dependency	1.0	4.80706
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044445
underlie	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4282	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
ISONIPECOTIC ACID	DGIdb Drug Targets 2026	1.0	0.048606
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29291
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97325
CRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12108
OXCT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52027
increases	GeneRIF Biological Term Annotations	1.0	null
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04808
Exocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.775
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SKM-1	GDSC Cell Line Gene Expression Profiles	1.0	1.64898
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.38345
Epilepsy, Tonic-Clonic	CTD Gene-Disease Associations	1.0	1.18521
CKMT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88018
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915796
GSE190316,GSE190324_10_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Asymmetric synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.42
EEF1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47438
HIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77327
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34611
WM115	DepMap CRISPR Gene Dependency	1.0	5.49019
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52265
H3K27me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56227
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61704278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20278
MORCPR	DepMap CRISPR Gene Dependency	1.0	2.65757
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_4351_OE_Sall1_SRP409197	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.49992
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55592
Cognitive disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.93651
hsa-miR-584	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33433
Nuclear exosome targeting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05452
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
neutropenia	GWASdb SNP-Disease Associations	1.0	0.688615
PRIMPOL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07527
ZNF235	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43123
doxepin-2384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADHD and autism ASD pathways	WikiPathways Pathways 2024	1.0	null
TM2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61813
Lateral dorsal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
Neurotransmitter receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.93
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-541	TargetScan Predicted Conserved microRNA Targets	1.0	0.088999
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65189
AK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40993
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21723
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF229	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4337
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.864441
hsa-miR-548ae	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
HES7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86532
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.844752
DMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0347
RPMI8226	DepMap CRISPR Gene Dependency	1.0	4.23601
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36494
GCT	DepMap CRISPR Gene Dependency	1.0	2.84023
Alcohol use disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.76
Cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.164
BTAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39635
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10249
Postsynapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.824
ESTAZOLAM	DGIdb Drug Targets 2026	1.0	0.0232464
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4065
equilin-3039	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC95	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76878
hsa-miR-4417	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
BRD-K83180232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02005
BRD-K16496880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65966
BRD-K48615268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05905
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98828
SLCO4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9602
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.100062
BRD-K16255400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13509
DLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76872
Child Development Disorders, Pervasive	HuGE Navigator Gene-Phenotype Associations	1.0	null
SETDB1	ChEA Transcription Factor Targets	1.0	null
Dyspnea	CTD Gene-Disease Associations	1.0	1.03084
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44152
HELQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03168
familial atrial fibrillation	GWASdb SNP-Disease Associations	1.0	0.520364
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08484
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72376
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATXN7L3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56283
ANGPTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34399
WM2664	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76181
Perturb_6234_KO_Mecp2_SRP045354	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.3151
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01854
hsa-miR-4330	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.05471
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88081
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.858571
SECOBARBITAL SODIUM	DGIdb Drug Targets 2026	1.0	0.0334167
INTS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25995
NCI-H345	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66564
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20905
RNF145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38637
ETS2_KD_GSE62168_258_mouse_mouse trophoblast stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60631127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24709
SACS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94904
hsa-miR-127-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K66973998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00642
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19646
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14914
regulation of postsynaptic membrane potential	GO Biological Process Annotations 2023	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206400_3_v_2_nusinersen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.663
Piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.873
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3973	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NUDT16L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28246
r3 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00604
BRD-K51535480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4996
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30876
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07723
Hypertension	CTD Gene-Disease Associations	1.0	1.92642
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65077
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.52002
A3-KAW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02302
Synaptic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.677
Akathisia, Drug-Induced	CTD Gene-Disease Associations	1.0	1.20816
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29496
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09574
Heptabarbital	HMDB Metabolites of Enzymes	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20297
GRIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8276
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35227
newly	GeneRIF Biological Term Annotations	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3217937-1756-0500-4-471-S1.XLS-Gene_Set-P53_targets_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TRABD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69308
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3913
WRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37712
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37849
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33386
Subparafascicular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02006
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.354
Postsynaptic specialization	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.457
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.275
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33315
HBS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67484
Lorazepam	DrugBank Drug Targets	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BSG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45139
PFAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94744
RT11284	CCLE Cell Line Gene CNV Profiles	1.0	1.59669
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02637
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34626
synapse	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.12564
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3683
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96715
TMEM230	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.26029
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.33803
PROSER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15998
MALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17024
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.320697
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Xeroderma pigmentosum group E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8455
gamma-aminobutyric acid signaling pathway	GO Biological Process Annotations 2025	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.116
REMIMAZOLAM BESYLATE	DGIdb Drug Targets 2026	1.0	0.0334167
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13433
BRD-K88421348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20877
chloride transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
periventricular stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33579
Perturb_9215_KO_Rai1A_SRP260241	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.08389
Anoxia	CTD Gene-Disease Associations	1.0	1.58351
UROS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81978
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3823
METHOHEXITAL SODIUM	DGIdb Drug Targets 2026	1.0	0.0334167
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
studied	GeneRIF Biological Term Annotations	1.0	null
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8374
TPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62728
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28421
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38885
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE211286_4_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.832819
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WB-4101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12242
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78209
HES3_KO_GSE64449_186_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K20530300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02916
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02969
GABA-A receptor complex	GO Cellular Component Annotations 2023	1.0	null
BRD-K12440228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12314
BRD-K62781263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84262
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06025
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854454
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.1784
BRD-K96839404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54063
NUP85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42674
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951667
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.108
dorsal lateral geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30562
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-0.893212
SYCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13939
AP1S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95469
Dorsal part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37531
MIOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54914
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00437
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897778
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14129
MEIOSIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.96742
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47901
PMC8185471-mmc5.xlsx-SOX15KO_unique-Unique_up-_downregulated_genes_in_SOX15-_-_cells_Related_to_Figure_S7_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.392011
Presynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
Perturb_1167_KD_ETV6_ERP128093	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PPARA_KO_GDS3748_516_mouse_Livers	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.362
BRD-K12202458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19045
BRD-K05250921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52109
SECOBARBITAL	DGIdb Drug Targets 2026	1.0	0.106933
S100PBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06672
FLURAZEPAM HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.0334167
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC11360852-40246_2024_660_MOESM2_ESM.pdf-25-SALL1_SALL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Neuron projection membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Alprazolam	DrugBank Drug Targets	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26273
Auditory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.048
TSPAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72143
GTEx BloodVessel 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	30.4442
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
ODAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94135
Cocaine-Related Disorders	CTD Gene-Disease Associations	1.0	1.25838
ZNF692	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96087
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46805838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01563
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Tremor, Rubral	DisGeNET Gene-Disease Associations	1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rhoptry	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Prostate adenocarcinoma_PRAD_TCGA-HC-8266-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50413145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.34683
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86776
CENOBAMATE	DGIdb Drug Targets 2026	1.0	0.0411282
Caudate putamen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.315
Ventral striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.224
BRD-K25176380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27173
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57134
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95075
PHLDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41594
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
METHAQUALONE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.0334167
flumazenil	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Torsades de Pointes	CTD Gene-Disease Associations	1.0	1.29688
BRD-K30589514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73705
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040692
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUZ12-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03643
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.2606
PHF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15669
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66195
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66095
Frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.029
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7741
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57442
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganaxolone	DrugBank Drug Targets	1.0	null
hsa-miR-548am	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24151
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36144
abnormal synaptic transmission	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-4753-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
BRD-K30145193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0267
Dendritic tree	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
5&alpha;-pregnan-3&alpha;-ol-20-one	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.02821
brain	GTEx Tissue Gene Expression Profiles	1.0	1.77894
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ventral nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56939
periventricular stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01316
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42524
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34372
SFXN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78337
ACSBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86662
BRD-K98757606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18009
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23737
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.7451
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
however	GeneRIF Biological Term Annotations	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
heart	GTEx Tissue Gene Expression Profiles	1.0	1.04569
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.524
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.085
hsa-miR-548u	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
system development	GO Biological Process Annotations 2015	1.0	null
Flumazenil	DrugBank Drug Targets	1.0	null
ATP6V1G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.924
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997533
tretinoin-6170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
BRD-K77797589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12466
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.96117
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04568
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56623
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN014_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39532
CRCGN015_HEPG2_48H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19365
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47937
Katanin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.708
BRD-K30632097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3585
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atypical autism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
ABAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96371
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13319
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58903
BUTOBARBITAL	DGIdb Drug Targets 2026	1.0	0.106933
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923752
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95285
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040667
BRD-K84158675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09294
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.369
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-23b	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Status Epilepticus	DisGeNET Gene-Disease Associations	1.0	null
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40469
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3101
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.26414
trichostatin A-1561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10391
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.21
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.194116
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03981
MATR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7278
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47365
ARHGAP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78962
ASXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37099
ACADM_KO_GDS4546_512_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8433-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5956
GTEX-UJHI-0326-SM-4IHJE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982606
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.90546
unique	GeneRIF Biological Term Annotations	1.0	null
gilles de la tourette syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.759008
BRD-K28811650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59547
NR3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5293
BRD-K11389666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08976
IFT52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41659
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01759
inorganic anion transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3973	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
heliotrine-2180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-577	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
BRD-K63998843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19606
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Bipolar I disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
Dentate granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.532
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9412
PPP1R15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39962
PMC7913835__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.83476
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LCMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57526
Perturb_15827_OE_Nrf2_SRP291724	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.88007
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.3489
Brodmann area 36	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
Methylphenobarbital	HMDB Metabolites of Enzymes	1.0	null
agranulocytosis	GWASdb SNP-Disease Associations	1.0	0.688615
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05854
inhibition	GeneRIF Biological Term Annotations	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.22171
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.56755
RBBP5	ENCODE Transcription Factor Targets	1.0	null
TNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42925
BRD-K28108927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99482
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1274
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.735
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42253
MYO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.096
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3688-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14927
IDH3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69418
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Dizziness	CTD Gene-Disease Associations	1.0	1.39254
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
TNNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.8067
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11611169-pone.0314092.s001.docx-3-PPARG_PPARG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Diazepam	CTD Gene-Chemical Interactions	1.0	null
MYL12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17776
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABA-A receptor activity	GO Molecular Function Annotations 2025	1.0	null
PYCARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73455
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
MTA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31963
postsynaptic membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23864
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.77
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13864
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P6-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW872	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59125
BRD-K70198986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02905
Cingulate gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.478
NEU3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2469
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56642
Early infantile epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
Quazepam	DrugBank Drug Targets	1.0	null
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12303
plasma	Phosphosite Textmining Biological Term Annotations	1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10197
CIPEPOFOL	DGIdb Drug Targets 2026	1.0	0.0334167
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.619442
SPSB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07183
Opiate dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859985
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LORAZEPAM	DGIdb Drug Targets 2026	1.0	0.06416
medial habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870892
Cerebral cortical neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.66
periventricular stratum of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1126
rolipram-3072	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dyskinesia, Drug-Induced	CTD Gene-Disease Associations	1.0	1.13381
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9373
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
reticulum	Phosphosite Textmining Biological Term Annotations	1.0	null
VRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68677
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.970631
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01599
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7924-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26807
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24257
IGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0311
Confusion	CTD Gene-Disease Associations	1.0	1.38696
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0294
CLONAZEPAM	DGIdb Drug Targets 2026	1.0	0.0729091
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52272
hsa-miR-4477a	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
ILRUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15494
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52639
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38334
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
trichostatin A-3114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
METTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84647
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.982028
Lennox-Gastaut syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
JHOM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86995
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52373
Primidone	DrugBank Drug Targets	1.0	null
benfotiamine-2177	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K41025232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58999
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.204
NCI-H446	GDSC Cell Line Gene Expression Profiles	1.0	1.73413
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4326
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8064323__F10	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28066
hsa-miR-556-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6821
clemastine-2412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
GSE168807_2_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.832804
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96636
ZC3H11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18567
ESRRG_Deficiency_GDS2811_638_mouse_Fetal heart - Homozygous null mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.283
ZNF143	ENCODE Transcription Factor Targets	1.0	null
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.847044
ZNF592	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53353
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K58964288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13797
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.38345
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4797-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
transmitter-gated monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
ENDOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82452
cellular_component	GO Cellular Component Annotations 2015	1.0	null
SIGM5	CCLE Cell Line Gene Expression Profiles	1.0	1.64194
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57183
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25357
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17481
intermediate (interpositus) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29163
AKT1_knockdown_141_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.4632
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964842
APOBEC3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12656
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.873
JHH-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1651	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.237
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48026
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21563
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866192
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
maximally	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870353
lateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09986
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
earlier	GeneRIF Biological Term Annotations	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5689
FAM86C2P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2546
PRKDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54676
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07122
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.01565
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.976447
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29957
BRD-K71452779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10534
Synaptic cleft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.447
CDYL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38166
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12517
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Dendrite	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82568
ACHN	BioGPS Cell Line Gene Expression Profiles	1.0	0.837992
EP300	ENCODE Transcription Factor Targets	1.0	null
Lethargy	CTD Gene-Disease Associations	1.0	1.14507
CIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75025
Tegmentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.543
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.18159
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24393
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.83548
BRD-K71538933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37407
PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940018
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.51974
bretazenil	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
SNU719	CCLE Cell Line Gene Expression Profiles	1.0	1.71342
amnestic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.570329
hsa-miR-4268	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Interposed nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37927
chloride transmembrane transport	GO Biological Process Annotations 2025	1.0	null
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30357
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08125
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42744
BRD-K70765133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05379
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1962
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.026
SHSY5Y	CCLE Cell Line Gene Expression Profiles	-1.0	-3.71165
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.88917
genotyped	GeneRIF Biological Term Annotations	1.0	null
NFYA	JASPAR Predicted Transcription Factor Targets	1.0	null
gabrq	GeneRIF Biological Term Annotations	1.0	null
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78588
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3955
reflect	GeneRIF Biological Term Annotations	1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6775
TAF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31305
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99331869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24742
ACADS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72714
REX1BD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22738
ICC3	DepMap CRISPR Gene Dependency	1.0	2.35382
cardiac protection against ros	Biocarta Pathways	1.0	null
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.100791
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92867
neutropenia	GWASdb SNP-Phenotype Associations	1.0	0.590389
NIF3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76679
single organism signaling	GO Biological Process Annotations 2015	1.0	null
CLDN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27842
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.858416
Neurotransmitter-gated ion-channel	InterPro Predicted Protein Domain Annotations	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924892
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.66964
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48036
BRD-K47966145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08672
GSE134986_2_v_8_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ability	GeneRIF Biological Term Annotations	1.0	null
NCIH1993	DepMap CRISPR Gene Dependency	1.0	3.84687
KAT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82403
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.53724
GSE190316,GSE190324_0_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.98292
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
Lassa Fever Virus_8hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.00238
MDA-MB-468	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44452
BRD-K18623962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18428
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28307
BRD-K48113764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18508
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03245
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13921
TRIM28	ChEA Transcription Factor Targets	1.0	null
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K95160020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76454
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4223
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09364
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60915
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.807718
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.199
regulatory	GeneRIF Biological Term Annotations	1.0	null
GABA receptor activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35369
PUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93117
synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.292157
Necrosis	CTD Gene-Disease Associations	1.0	1.555
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11211
REM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14913
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.27378
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.833642
NBsusSR	GDSC Cell Line Gene Expression Profiles	1.0	1.85626
PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_B_BNC1	Rummagene Transcription Factor Associations 2026	1.0	null
Asperger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
POLR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2642
SMURF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90719
Pars reticulata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
periventricular stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07597
Delirium	CTD Gene-Disease Associations	1.0	1.84924
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34428
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33938
BRD-K35792251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42054
MARK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13419
dendrite membrane	GO Cellular Component Annotations 2023	1.0	null
GANAXOLONE	DGIdb Drug Targets 2026	1.0	0.0594074
SHP77	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3212
Acamprosate	DrugBank Drug Targets	1.0	null
pentamidine-639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21358
SETDB1-19884255-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06062
INSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50388
CAND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5071
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38837
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K10048365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29322
FLUNITRAZEPAM	DGIdb Drug Targets 2026	1.0	0.084421
BICR22	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56886
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44711
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21722
Metharbital	HMDB Metabolites of Enzymes	1.0	null
Chromosome 4q21 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE185519_1_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LGALS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50205
[<sup>3</sup>H]Ro154513	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.11603
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
GSE131649_6_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Posterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
Dendrite membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49914
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83315
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15115_KD_Rtn4_SRP278924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.40495
Prestwick-1085-6131	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tetrahydrodeoxycorticosterone	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1328
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
anion channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
subunit	GeneRIF Biological Term Annotations	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RASL11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55126
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K36539857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4093
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6829
FBXL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54806
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5704
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52473
Subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
PRAZEPAM	DGIdb Drug Targets 2026	1.0	0.024303
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-PBX3_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
schizophrenia ;  autism	GAD Gene-Disease Associations	1.0	null
DEPDC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56813
Cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.285
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.996127
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8064323__F10	PFOCR Pathway Figure Associations 2023	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.921847
BRD-K16207499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52534
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23758
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8797
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19915
ZBTB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13369
nilutamide-3104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K85441584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37794
RILPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21253
ZEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05939
STARD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11811
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51521
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90037
periventricular stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16982
fluoxetine_mus musculus_gpl1261_gse35761	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63642
TRIAZOLAM	DGIdb Drug Targets 2026	1.0	0.0534667
MOLM13	CCLE Cell Line Gene Expression Profiles	1.0	1.39513
CCLFPEDS0008T	DepMap CRISPR Gene Dependency	1.0	3.98375
MAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89601
BRD-K07588901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17763
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18142
atrial fibrillation	GWASdb SNP-Phenotype Associations	1.0	0.443881
BRD-K79568363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08922
MIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84117
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4502	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981953
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.008
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Perturb_15061_OE_Trp53_SRP345823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.44412
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.844
prion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.270819
MSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07834
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829251
Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
CRCGN008_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13225
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF677	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42741
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983969
hsa-miR-4787-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
r5 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17115
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953698
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98064
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Oxazepam	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-24	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Anterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18224
BRD-K49981566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73698
WT1-20215353-NEPHRON PROGENITOR-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20305
BRD-K71204648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44113
lower	GeneRIF Biological Term Annotations	1.0	null
seizures	GeneRIF Biological Term Annotations	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06025
Perineuronal net	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
GABA-gated chloride ion channel activity	GO Molecular Function Annotations 2025	1.0	null
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEx BloodVessel 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	17.2403
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34183
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K08107521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03766
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.48299
GSE174498,GSE174500_5_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H9	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.50831
oxybenzone-3092	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EXTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01755
biological regulation	GO Biological Process Annotations 2015	1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20083
NCIH2087	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7704
they	GeneRIF Biological Term Annotations	1.0	null
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995687
Avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.868
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88629
BRD-K67715154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42033
NCI-H1105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13873
Dendritic branch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
hsa-miR-874	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A4 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90373
pvalues	GeneRIF Biological Term Annotations	1.0	null
TT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35055
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.461
U87	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.844467
Psychomotor Disorders	CTD Gene-Disease Associations	1.0	1.56509
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
IFT80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53331
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18303
BRD-K27982554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0632
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Heroin dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
estradiol-1149	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Juvenile myoclonic epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
BRD-K07035171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30002
ATP5MK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1848
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.938935
liminal part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03252
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.789796
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980445
15273739-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
isonipecotic acid	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
SFT2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83546
BRD-K28057105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24706
Hypotension	CTD Gene-Disease Associations	1.0	1.68253
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
METHYPRYLON	DGIdb Drug Targets 2026	1.0	0.0334167
pituitary	GTEx Tissue Gene Expression Profiles	1.0	0.958531
hsa-miR-345	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
hsa-miR-4646-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
SDR42E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28626
ATP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41444
benzodiazepine receptor activity	GO Molecular Function Annotations 2023	1.0	null
mantle zone of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16473
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34604
hsa-miR-23a	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Abnormal Coordination	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86204
Cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.515
HKA1	DepMap CRISPR Gene Dependency	1.0	3.33254
BRD-K17239874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01294
PADSEVONIL	DGIdb Drug Targets 2026	1.0	0.0281403
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05381
BRD-K93159873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85165
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
chloride transmembrane transport	GO Biological Process Annotations 2015	1.0	null
BRD-K92312193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36188
abnormal inhibitory postsynaptic currents	MGI Mouse Phenotype Associations 2023	1.0	null
r6 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23318
OPTN_KD_GDS2892_268_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35547
BRD-K15609977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00451
MYC	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Ischemia	CTD Gene-Disease Associations	1.0	1.13586
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937751
Orphan transporters	Reactome Pathways 2014	1.0	null
PPID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18477
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10146
BRD-K95913506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00239
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4672	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863532
corrected	GeneRIF Biological Term Annotations	1.0	null
GSE231720,GSE231724_3_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
MAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43065
hsa-miR-3545-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6192
TETRAHYDRODEOXYCORTICOSTERONE	DGIdb Drug Targets 2026	1.0	0.0891111
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lasalocid-3021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PPIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27579
membrane	GO Cellular Component Annotations 2015	1.0	null
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STOML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67499
TMK1	DepMap CRISPR Gene Dependency	1.0	2.06947
KMT2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53446
SERPINE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56715
G124	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941063
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46986
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54882
SLC39A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71676
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6143
GSE210580_0_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.071
Chlordiazepoxide	DrugBank Drug Targets	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEC63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94623
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97498
BRD-K27035180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40361
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
PU.1_KD_GDS2411_175_mouse_Preleukemic hematopoietic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-4465	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
DAPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40124
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4995-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.839986
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24257
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96322
BRD-K02655584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01899
SUZ12-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15714771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6563
PLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21742
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37078
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nicotine Dependence	DisGeNET Gene-Disease Associations	1.0	null
flunisolide-2168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96348
Talbutal	DrugBank Drug Targets	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29246
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3113
SJSA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61989
SLC6A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81249
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.955
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18156
SNU620	CCLE Cell Line Gene Expression Profiles	1.0	1.55127
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42068
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_K27me3_17603471_mouseNPC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00869
PABPC1L2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88186
PECAPJ41CLONED2	DepMap CRISPR Gene Dependency	1.0	3.52597
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.73645
Granule cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
Nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24539
MTSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98305
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.436
Amobarbital	DrugBank Drug Targets	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16359
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04363
GABA-A receptor activity	GO Molecular Function Annotations 2023	1.0	null
TSPYL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42604
WDR54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3319
Striate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1442
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5878
Effect of omega 3 PUFA on Huntington 39 s disease pathways	WikiPathways Pathways 2024	1.0	null
ligand-gated monoatomic anion channel activity	GO Molecular Function Annotations 2025	1.0	null
PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_A_BNC1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal sensory capabilities/reflexes/nociception	MPO Gene-Phenotype Associations	1.0	null
KRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01235
EVA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85231
ZNF611	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27981
FAM117A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42889
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.986691
PENTOBARBITAL SODIUM	DGIdb Drug Targets 2026	1.0	0.0802
gabaa	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2830-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21996934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27708
B3GNT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61033
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06021
Dorsal striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.195
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860562
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
severity	GeneRIF Biological Term Annotations	1.0	null
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00588
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.66149
ZFP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48938
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r2 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16298
Poisoning	CTD Gene-Disease Associations	1.0	1.20064
hsa-miR-3124-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
RBM38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.26942
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9468
CLOMETHIAZOLE	DGIdb Drug Targets 2026	1.0	0.0267333
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11357
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40551
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34694
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39417
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949616
BRD-K70695911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01058
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.229
BRD-K54872884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02654
BRD-K32170456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19337
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46089
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
CNPY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19823
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59325
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.174247
H3K27me3_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34277
transport	GO Biological Process Annotations 2015	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sleep Initiation and Maintenance Disorders	CTD Gene-Disease Associations	1.0	1.18193
UBQLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80959
CIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1548
receptors	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3439
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.884944
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH358	CCLE Cell Line Gene CNV Profiles	1.0	1.60237
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.031793
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8962
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92201
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7686
MPHOSPH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.34697
Cell leading edge	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.71344
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
HALOTHANE	DGIdb Drug Targets 2026	1.0	0.0172473
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40093
BRD-K36544054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21146
[3H]CGS8216	DGIdb Drug Targets 2026	1.0	0.0891111
CASZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70972
PPP1CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97212
intermediate stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4821
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
problems	GeneRIF Biological Term Annotations	1.0	null
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF682	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81137
CEBPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41444
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86529
[<sup>3</sup>H]gabazine	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
ZNHIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0858
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFE-280	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50272
HECTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94301
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
NYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54851
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58825
BRD-K44722555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51654
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841765
PNRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19149
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.945101
DPPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67047
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15282
tic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.745985
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1179	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
UACC893	DepMap CRISPR Gene Dependency	1.0	2.4474
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K75657700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38161
PKM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85478
Hallucinogen dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5875-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56272400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31856
Urinary Retention	CTD Gene-Disease Associations	1.0	1.13758
BRD-K08829593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61212
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5278
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06686
CRCGN008_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32085
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01326
KM12	DepMap CRISPR Gene Dependency	1.0	3.38364
estrone-3071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABA receptor activation	Reactome Pathways 2014	1.0	null
CFAP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57331
BRD-A71880598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.479
DCAF12L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05593
pterigoid muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02497
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Tic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61718
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.910871
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01374
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.99574
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Drug dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
PHF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31205
magnocellular (medial) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07896
hsa-miR-498	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
ADAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95907
GTEX-R53T-0726-SM-48FCS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05903
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A76W-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.18587
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950711
intermediate stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55416
developmental	GAD High Level Gene-Disease Associations	1.0	0.293278
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.871061
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44751
Hepatic Cirrhosis_Liver_GSE6764	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.00175
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47715
simvastatin-3002	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Unconsciousness	CTD Gene-Disease Associations	1.0	1.09857
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.47475
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCIDAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48644
TP53_01_10	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.29227
HS229T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55566
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Postpartum depression	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
SMC3	ENCODE Transcription Factor Targets	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11333
hippocampal	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC5054603__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X261-0011-R5A-SM-3NMB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09426
Serotonergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
CTNNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30021
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04762
Amobarbital	HMDB Metabolites of Enzymes	1.0	null
MAPKAPK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6722
CRCGN016_MCF10A.TP53.M_24H:D15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53412
CPNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.786
IL17RB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62731
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57497543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4429
gamma-aminobutyric acid signaling pathway	GO Biological Process Annotations 2023	1.0	null
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95115
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
L-type voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
Meprobamate	DrugBank Drug Targets	1.0	null
sensationseeking	GeneRIF Biological Term Annotations	1.0	null
azathioprine-338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01678149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37017
RERFGC1B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73791
mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	2.14985
PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24246
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.947138
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Alpha-hydroxyalprazolam	HMDB Metabolites of Enzymes	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3348
insertion	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64811593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42535
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35187
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01176
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16523
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.870908
BRD-K76154866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8974
BRD-K02747732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02672
TETRAZEPAM	DGIdb Drug Targets 2026	1.0	0.0334167
ACAD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75272
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974455
THIOPENTAL	DGIdb Drug Targets 2026	1.0	0.0972121
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07334
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11342
Juvenile myoclonic epilepsy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
ISOFLURANE	DGIdb Drug Targets 2026	1.0	0.0178222
Exocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.663
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10295
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14169
CBFA2T3_KD_GDS4045_458_human_Non-Hodgkin's lymphoma Reh cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.292484
Gamma-Aminobutyric acid	HMDB Metabolites of Enzymes	1.0	null
LY-294002-429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15045
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13303
Gamma-aminobutyric-acid A receptor, alpha subunit	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K00377328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04132
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06825
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
[18F]FLUOROETHYLFLUMAZENIL	DGIdb Drug Targets 2026	1.0	0.0891111
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18047
Bromazepam	HMDB Metabolites of Enzymes	1.0	null
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.0054
PMC2834616__F4	PFOCR Pathway Figure Associations 2023	1.0	null
HALAZEPAM	DGIdb Drug Targets 2026	1.0	0.0267333
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
BV-173	GDSC Cell Line Gene Expression Profiles	1.0	2.09939
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55797
Middle temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
Flunitrazepam	HMDB Metabolites of Enzymes	1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
TRIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05181
3'-Hydroxyhexobarbital	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC26A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65616
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TOPIRAMATE	DGIdb Drug Targets 2026	1.0	0.010282
OVCAR8	BioGPS Cell Line Gene Expression Profiles	1.0	0.897417
LS123	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13329
BRD-K65875972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00647
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80033
hsa-miR-4498	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
CBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02394
anterior pretectal nucleus, ventral core part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01718
NCIH460	DepMap CRISPR Gene Dependency	1.0	2.58596
chloride channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
HP1BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33954
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97128200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57667
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RT112	CCLE Cell Line Gene CNV Profiles	1.0	1.38165
NOP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40077
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.74767
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	1.04365
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.49315
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859843
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16094
dysfunction	GeneRIF Biological Term Annotations	1.0	null
Autistic Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^3_None_GSE43302	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.15325
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971001
CHEK1_knockdown_142_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.20485
KYAE1	DepMap CRISPR Gene Dependency	1.0	2.5457
hymecromone-3045	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cholestasis	CTD Gene-Disease Associations	1.0	1.10069
C2BBE1	CCLE Cell Line Gene Expression Profiles	1.0	1.52623
hsa-miR-1227	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133516_5_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AU565	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intermediate stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42653
HCC2450	DepMap CRISPR Gene Dependency	1.0	2.03572
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10837
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-451b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
HUNS1	CCLE Cell Line Gene Expression Profiles	1.0	1.48366
Pentobarbital	HMDB Metabolites of Enzymes	1.0	null
UST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8632
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03914
BRD-K44652223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28537
HEXOBARBITAL	DGIdb Drug Targets 2026	1.0	0.106933
Medial geniculate complex, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28347
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
initially	GeneRIF Biological Term Annotations	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.881047
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17732_KO_Tmprss2_SRP046010	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.1192
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4661
BRD-K52854560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03252
CDK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12324
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6211
ABL1_knockdown_144_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.21837
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
extracellular ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K28640166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34019
Becker	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77845
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
obesity	GWASdb SNP-Disease Associations	1.0	0.964504
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73674
CLPP_KO_GSE40207_397_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932011
Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2081
PDIK1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2561
pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05681
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
CDK4_knockdown_143_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.39883
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
mRNA_ZFAND3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GRIK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49626
Hyperplasia	CTD Gene-Disease Associations	1.0	1.052
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47555
NPIPA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79092
Neurotransmitter-gated ion-channel, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
DTX3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84199
Etomidate	DrugBank Drug Targets	1.0	null
cerebellar nuclei of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43001
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.132
BRD-K59445060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23753
BRD-K89832379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43172
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5502
EGR1	ENCODE Transcription Factor Targets	1.0	null
transgenic	GeneRIF Biological Term Annotations	1.0	null
CCDC174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35117
NCI-H1666	COSMIC Cell Line Gene Mutation Profiles	1.0	null
acid	GeneRIF Biological Term Annotations	1.0	null
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
E2F6	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55619
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831943
APLNR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06341
APIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42031
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16547
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86369
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24503
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78407
Geniculate group, dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18433
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SIRT3_KO_GDS4058_16_mouse_BROWN ADIPOSE TISSUE	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.992792
FAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97908
hsa-miR-3144-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
FMNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91399
BRD-K67998155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17744
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47002
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.17095
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.4682
CCNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93669
brain	HPA Tissue Gene Expression Profiles	1.0	1.31086
parvicellular part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30773
hsa-miR-510	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
OS252	DepMap CRISPR Gene Dependency	1.0	3.70235
PMC7738628__F5	PFOCR Pathway Figure Associations 2023	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34815
SUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.5154
NCIH1838	CCLE Cell Line Gene CNV Profiles	1.0	1.37868
HDAC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81461
Central Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.05535
ALG12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37336
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HNRNPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16852
MGRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45355
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05818
leukopenia	GWASdb SNP-Phenotype Associations	1.0	0.590389
medial (fastigial) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80947
GSE213988_0_v_1_rrm2_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP4K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40374
BRD-K80715600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03553
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36519
lateral part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41759
Autosomal recessive chronic granulomatous disease 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1975
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874166
HS834T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63153
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
GSE184133,GSE184137_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Substance-Related Disorders	CTD Gene-Disease Associations	1.0	1.44735
hyperalgesia	MPO Gene-Phenotype Associations	1.0	null
Perturb_12035_KO_Ccr2_SRP247656	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.3201
Childhood electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
hsa-miR-4436b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.66406
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MIDAZOLAM HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.0458286
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5374
Cognitive decline (age-related)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.376119
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11355
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853622
hsa-miR-181b	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLORAZEPATE	DGIdb Drug Targets 2026	1.0	0.0534667
ZGLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02258
MVB12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38688
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08615
hsa-miR-4499	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
Psychoses, Substance-Induced	CTD Gene-Disease Associations	1.0	1.23806
chr4_46991545_G_C_b38	GTEx eQTL 2025	1.0	1.6679
BRD-K24554824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60654
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4432	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23693
PSMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61534
HNRNPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21174
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bicuculline	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
hsa-miR-4694-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.980564
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	-1.0	null
transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.00547
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850206
MFE280	DepMap CRISPR Gene Dependency	1.0	4.28176
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52195
Brain Lower Grade Glioma_LGG_TCGA-HT-7881-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebral subcortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
Mental Disorders	CTD Gene-Disease Associations	1.0	1.15089
gh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9519
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Intergeniculate leaflet of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13537
GGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14095
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.696
gabrb1	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
FBXL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98191
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57733
Visual cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.4
AFTPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10443
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36021
Stress, Psychological	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4307	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
RO60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66146
hsa-miR-34b	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06273
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29539
ACAD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3749
gaba	GeneRIF Biological Term Annotations	1.0	null
PAX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39549
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.921181
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35577
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lateral dorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01365
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23531
BRD-K15350548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43629
PMC8045172-13018_2021_2402_MOESM1_ESM.txt--AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
stratifying	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64577
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15047
SW948	CCLE Cell Line Gene Expression Profiles	1.0	1.35328
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95629
Insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.185
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF239	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25548
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11296
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5023
BRD-K84052780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11795
obsessive-compulsive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03515
ZNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20543
cellular process	GO Biological Process Annotations 2015	1.0	null
TDRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65993
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50438
idazoxan-3088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RABEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46545
TBP	ENCODE Transcription Factor Targets	1.0	null
deletion	GeneRIF Biological Term Annotations	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.86677
SIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01791
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30584
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57188
Learning Disorders	CTD Gene-Disease Associations	1.0	2.12206
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23232
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7798
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MSANTD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83297
Prefrontal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.002
TXNDC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01372
Anterior group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00791
ETHCHLORVYNOL	DGIdb Drug Targets 2026	1.0	0.0334167
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65098
Nitrazepam	DrugBank Drug Targets	1.0	null
Cerebral Hemorrhage	CTD Gene-Disease Associations	1.0	1.35705
BRD-K61934967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19165
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25461
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
S100A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51074
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.15256
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5474
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38202
WRAP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49276
BRD-K04667232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25365
19808871-TableS3	GeneSigDB Published Gene Signatures	1.0	null
CEP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05569
Thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24631
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902809
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841765
mice-inbred-c57bl	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K09373762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0759
Lateral ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.636
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851193
Brain Lower Grade Glioma_LGG_TCGA-DU-7302-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18412
CEP250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80918
Myoclonus	CTD Gene-Disease Associations	1.0	1.35906
ATL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41825
Perturb_753_KD_ABAT_SRP385901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.97785
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69740275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8502
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19169
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
abnormal cns synaptic transmission	MPO Gene-Phenotype Associations	1.0	null
Amnesia	CTD Gene-Disease Associations	1.0	1.73999
movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.892948
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40886
BRD-K68743686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31155
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30351
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9542
AMPA glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.604
JVM2	CCLE Cell Line Gene Expression Profiles	1.0	1.40568
BRD-K78397696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53254
NKX2-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3473
TJP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95041
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CDC14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12846
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3478
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02132
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.11849
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21432
CHLORDIAZEPOXIDE	DGIdb Drug Targets 2026	1.0	0.0763809
Substance-Related Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K12493093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03409
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-2.34839
Central lateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88041
BRD-K40432489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83524
TM31	CCLE Cell Line Gene CNV Profiles	1.0	2.00593
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.727
parvicellular (lateral) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36965
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.386
Mediodorsal nucleus of the thalamus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60182
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.54848
Ligand-gated ion channel transport	Reactome Pathways 2014	1.0	null
Halothane	DrugBank Drug Targets	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7872
Lateral habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0491
SPDEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57663
ATG2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97498
BRD-K29636267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58963
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
RAD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6474
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4384
Synaptic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
mantle zone of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52574
Pilocarpine	CTD Gene-Chemical Interactions	1.0	null
BRD-A29371732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24407
NUMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80672
monoatomic anion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
PHYHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42689
LPS6	DepMap CRISPR Gene Dependency	1.0	2.0352
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09304
U251	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64923
PMC10657376-41467_2023_43213_MOESM7_ESM.xlsx-DaNs_EBF1-Unnamed_6_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5585-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17106
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56325
RNF2	ChEA Transcription Factor Targets	1.0	null
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8905
SCYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03484
r2 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0441
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.054088
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
gabazine	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2725-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2366
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS-578-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPIF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06839
pizotifen-3134	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21897482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1566
SG231	DepMap CRISPR Gene Dependency	1.0	3.17958
RNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81902
Thalamus, sensory-motor cortex related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34646
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07217
PHC1-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19688
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06491
Amnesia, Retrograde	CTD Gene-Disease Associations	1.0	1.08478
hsa-miR-3646	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.561
cortical	GeneRIF Biological Term Annotations	1.0	null
BRD-K02921955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72414
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
Hexobarbital	DrugBank Drug Targets	1.0	null
Perturb_13875_KO_LIN28B_SRP335506	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.1471
Restless legs syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
CBLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55711
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853728
SNU16	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53291
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950171
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
integument phenotype	MPO Gene-Phenotype Associations	1.0	null
cercopithecus-aethiops	Phosphosite Textmining Biological Term Annotations	1.0	null
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3364
KCNF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61652
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
premenstrual	GeneRIF Biological Term Annotations	1.0	null
BRD-K83619973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52006
Perturb_7031_KD_Casz1_SRP038989	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.88177
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
CAOV-3	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.83684
PRMT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04765
Glycinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.597
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.0923
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50789
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K77032979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24065
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33173
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
felbamate	CTD Gene-Chemical Interactions	1.0	null
abnormal behavioral response to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
GSE137914_2_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ligand-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
PMC2834616__F4	PFOCR Pathway Figure Associations 2024	1.0	null
ELF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85758
Alcoholism	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71975
FOXP2	ChEA Transcription Factor Targets	1.0	null
NPAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47334
Prostate adenocarcinoma_PRAD_TCGA-EJ-5495-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DHX32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31872
NB17	GDSC Cell Line Gene Expression Profiles	1.0	1.48781
eventual	GeneRIF Biological Term Annotations	1.0	null
BRD-K08759542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16438
PHF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60161
TNRC6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22434
RO15-4513	DGIdb Drug Targets 2026	1.0	0.0891111
LY-294002-328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
aconitine-1784	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2013_KO_Blimp1_SRP061216	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.80904
LAPTM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57302
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70702
TACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50149
autism	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00762
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7046-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61055
adolescence	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.493354
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CLOTIAZEPAM	DGIdb Drug Targets 2026	1.0	0.0267333
ventral posterolateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18104
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60819
Barbital	DrugBank Drug Targets	1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95629
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49H-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6591464-Table_4.xlsx-Sheet_1-AIRE_regulated_genes_TRA_annotated_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
srd5a1	GeneRIF Biological Term Annotations	1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.517
ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
Cornu ammonis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.023
GNG14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14554
Subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04676
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5308
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00234
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF233	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77246
Prostate adenocarcinoma_PRAD_TCGA-CH-5768-11A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-23c	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K22988729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8576
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.255
MRPL46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56171
Principal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
Cues	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832175
Basal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.657
synapse part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28188
19074828-TableS4	GeneSigDB Published Gene Signatures	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.358
Dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.1
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12776
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03131
CLPP_KO_GDS4791_377_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.923
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2688
NCI-H1770	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835169
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.975068
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68585
BRD-K38633800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09793
COR-L23	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4916
ZNF350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04005
nefopam-2355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07861
OXCT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67987
Catecholaminergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.913903
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0704
TBRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98018
Telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.284
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866914
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prosomere 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2599
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.22841
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.94233
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59776
alcohol dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.786394
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35406
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10709
CA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84846
LSM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12476
MPND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23914
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34891
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07021
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1016
BRD-K66802550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20635
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15034_KD_WDR5_SRP024294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.21612
KASUMI1	CCLE Cell Line Gene CNV Profiles	1.0	1.76075
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824899
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01461
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975766
RPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55447
communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160948
hsa-miR-4675	TargetScan Predicted Conserved microRNA Targets	1.0	0.02226
BACH1	ENCODE Transcription Factor Targets	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95677
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.1008
BRD-K00938872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28491
CSTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69405
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848088
BRD-K53752646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00302
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5699-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.638
ChIP_SUZ12_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03161
Pretectal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02136
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.95613
carbachol-3042	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-450b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
CASKIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.69487
hsa-miR-1260	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lassa Fever Virus_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.0507
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39954
mantle zone of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40974
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.87135
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4132_OE_PS2APP_SRP092532	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.54477
METHARBITAL	DGIdb Drug Targets 2026	1.0	0.0802
BRD-K68160857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44702
NPY1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.05518
hsa-miR-548x	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
ATN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37464
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24423
FIGNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94237
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02969
hsa-miR-485-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116129
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4985
Chromosome 15q11.2 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
Amnestic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
C1orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27437
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4448	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4398
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.827223
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary atrial arrhythmia	GWASdb SNP-Phenotype Associations	1.0	0.443881
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15955
hsa-miR-26b	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
autism	GAD Gene-Disease Associations	1.0	null
Methylphenobarbital	DrugBank Drug Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5677-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19712167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07685
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12505
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18096
BRD-K05753543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84658
BRD-K83481256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63131
cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67425
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32816
Chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.159
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34856
chemical synaptic transmission	GO Biological Process Annotations 2023	1.0	null
Medium spiny neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43154
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Fetal Death	CTD Gene-Disease Associations	1.0	1.06881
REMIMAZOLAM	DGIdb Drug Targets 2026	1.0	0.0267333
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IDI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21446
decreased thermal nociceptive threshold	MPO Gene-Phenotype Associations	1.0	null
H3K27me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
benzamide	CTD Gene-Chemical Interactions	1.0	null
hsa-miR-4677-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ACAMPROSATE CALCIUM	DGIdb Drug Targets 2026	1.0	0.0222778
Butalbital	HMDB Metabolites of Enzymes	1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3601
18855877-TableS2	GeneSigDB Published Gene Signatures	1.0	null
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.803127
Brain Lower Grade Glioma_LGG_TCGA-HT-7695-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42741
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50353
Perisynaptic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
BRD-K87080232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4053
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.85062
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cerebral gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.51
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978283
Inferior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14092
OCT4_KD_GDS1824_135_mouse_embryonic stem (ES)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-384	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
NCIH1792	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65543
BRD-K91905575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93925
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Midazolam	HMDB Metabolites of Enzymes	1.0	null
voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
U178	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45961
Hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.196
ZNF688	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87239
effect	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4659a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
CRCGN017_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1602
ZNF653	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41953
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleotide	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2591
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4274
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2549
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.529
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6033
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.826315
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.996127
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABA-A receptor complex	GO Cellular Component Annotations 2025	1.0	null
WDR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12395
STK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67991
UBE4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22593
BRD-K72800151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14847
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45439
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU668	DepMap CRISPR Gene Dependency	1.0	2.68747
Hippocampal pyramidal layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.786
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16494
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1103
membrane	GeneRIF Biological Term Annotations	1.0	null
ETFDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18966
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06821
RIDDLE syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
pentolonium-2343	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11136
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20896
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XPodNet - protein-protein interactions in the podocyte expanded by STRING(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46761
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	3.09736
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.511
furazolidone-3019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43865
UBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00102
LHX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61447
Medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28935
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.20958
range	GeneRIF Biological Term Annotations	1.0	null
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14558
NCI-H1623	COSMIC Cell Line Gene Mutation Profiles	1.0	null
roxithromycin-3331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HELZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55233
HCC1419	DepMap CRISPR Gene Dependency	1.0	3.7967
BRD-K82107433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36923
membrane	Phosphosite Textmining Biological Term Annotations	1.0	null
entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.474646
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85239
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57847
NMCG1	DepMap CRISPR Gene Dependency	1.0	3.21132
Medial geniculate complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08357
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969866
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66191
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K08241590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20484
BRD-K51490301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17823
Midazolam	DrugBank Drug Targets	1.0	null
CCDC28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17864
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
[3H]AZIETOMIDATE	DGIdb Drug Targets 2026	1.0	0.0668333
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75574
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.944486
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983674
r6 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01195
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K69491845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07528
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01896
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.843691
alpha4beta3gamma2l	GeneRIF Biological Term Annotations	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7863-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	1.52829
DIDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77842
no abnormal phenotype detected	MPO Gene-Phenotype Associations	1.0	null
BRD-K70254692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17879
Unverricht-Lundborg syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8125
BRD-K76966915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21219
SGPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22587
Ro15-4513	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
clone9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.352461
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4697
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UNC5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91763
HDAC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54699
Retrograde endocannabinoid signaling	KEGG Pathways 2026	1.0	null
USP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97911
SPG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73123
ZNF318	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63888
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ZMYM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16796
hsa-miR-4262	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00309
schizoaffective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.13882
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DDX39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.5781
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.877397
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29566
kidney aging	GAD Gene-Disease Associations	1.0	null
Central medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26507
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2478
Nucleus lentiformis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.401
BHLHA15_KO_GDS4341_145_mouse_pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.81628
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39191
RPS6KA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.254
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Autism	DisGeNET Gene-Disease Associations	1.0	null
PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
LIN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38715
GYS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81237
BRD-K60287661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25006
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42998
Polycystic ovary syndrome	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
anion transport	GO Biological Process Annotations 2015	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75574
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
ZNF84	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46727
SERPINB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89918
indicating	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4666-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.088999
BRD-K04652643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22649
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Sickle Cell Anemia_Endothelial cell_GSE9877	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.6469
biological_process	GO Biological Process Annotations 2015	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
BRD-K72060858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49128
SNU761	CCLE Cell Line Gene CNV Profiles	1.0	2.36074
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7090-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lassa Fever Virus_4hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.99918
BRD-K03599766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15115
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15311
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.832819
Neuronal System	Reactome Pathways 2024	1.0	null
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.365633
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.048118
BRD-K23404017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39961
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21871
BRD-K43798660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02404
VN1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73595
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDLM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56755
leukopenia	GWASdb SNP-Disease Associations	1.0	0.373686
BRD-K35386584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06246
Type 2 diabetes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
Tachycardia	CTD Gene-Disease Associations	1.0	1.50423
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19667
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intralaminar nuclei of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5357
Nausea	CTD Gene-Disease Associations	1.0	1.42589
Autistic Disorder	CTD Gene-Disease Associations	1.0	2.88009
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12725
oval paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15195
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.826324
BRD-K19122760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25091
GSE198228,GSE198245_0_v_2_apoe_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C17orf107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27304
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Ventral medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02498
hsa-miR-590-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
Psychotic Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
PBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29413
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10391
gabra2	GeneRIF Biological Term Annotations	1.0	null
WM115	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93023
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.810638
hsa-miR-3682-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Plastid inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.204
observed	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2793-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.61713
Vomiting	CTD Gene-Disease Associations	1.0	1.45962
Perturb_14783_KO_Mof_SRP225948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.16552
Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ethchlorvynol	HMDB Metabolites of Enzymes	1.0	null
BRD-K61660466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13986
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.888569
TNFRSF10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96283
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.430393
hsa-miR-769-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Enflurane	DrugBank Drug Targets	1.0	null
FAM53B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98029
H1-0	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42474
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12541
BRD-K52977489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18849
CWC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61678
articaine-3138	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.73062
Butethal	DrugBank Drug Targets	1.0	null
Medial geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05789
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6535
PROPOFOL	DGIdb Drug Targets 2026	1.0	0.0144504
SKRC31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92612
LY-294002-424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K04969760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67729
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8895
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lissencephaly 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
Weight Loss	CTD Gene-Disease Associations	1.0	1.97757
Inflammation	CTD Gene-Disease Associations	1.0	1.71503
DPRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58998
GABRA3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3685	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SNU520	CCLE Cell Line Gene Expression Profiles	1.0	1.67375
superficial stratum of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02022
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AS3MT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76768
GSE174383_6_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRSS22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97131
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.33545
supraventricular tachycardia	GWASdb SNP-Phenotype Associations	1.0	0.443881
Cannabis dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MINDY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99218
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.53949
NCI-H1299	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RUNX2	ChEA Transcription Factor Targets	1.0	null
BRD-K25600773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37884
Vision Disorders	CTD Gene-Disease Associations	1.0	1.03271
RUNX1	ChEA Transcription Factor Targets	1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
normal phenotype	MPO Gene-Phenotype Associations	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02108
PRIMIDONE	DGIdb Drug Targets 2026	1.0	0.0458286
GABPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82939
Lung adenocarcinoma_LUAD_TCGA-49-6742-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nicotine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.34
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98343
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893512
hsa-miR-1587	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
DISP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28511
Perturb_18483_KO_Ptk7_SRP106722	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.01515
rescinnamine-2130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18475
Neostriatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.546
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31563
hsa-miR-1245b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Epilepsy	HuGE Navigator Gene-Phenotype Associations	1.0	null
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01853
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.08202
BRD-K10416099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95633
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859289
Perturb_17362_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.7327
MYO1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76691
BRD-K05350978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22681
YD38	DepMap CRISPR Gene Dependency	1.0	3.38917
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7738628__F5	PFOCR Pathway Figure Associations 2024	1.0	null
PDHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41955
PMC9302637__F2	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-4728-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Ataxia	CTD Gene-Disease Associations	1.0	2.88009
BRD-K99660943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00484
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57889
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00905
Retrosplenial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
CRYBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00492
SERF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51337
hsa-miR-1297	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P2RY11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
BRD-K69375224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18706
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52592
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.678
ZNF382	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18596
ISOGUVACINE	DGIdb Drug Targets 2026	1.0	0.0594074
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89891
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31555
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.476772
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97144
SW900	CCLE Cell Line Gene CNV Profiles	1.0	1.54981
Oxazepam	DrugBank Drug Targets	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.27485
SUZ12-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50088
fluvastatin-3032	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79627231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88292
BRD-K56401968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58394
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.926851
posterior intralaminar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80525
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.924892
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02849
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
TIAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21924
BRETAZENIL	DGIdb Drug Targets 2026	1.0	0.0891111
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87803
ZNF618	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.264
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11588066-pnas.2410331121.sapp.pdf-63-BPTF_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Postsynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.69
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5709-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal inhibitory postsynaptic currents	MPO Gene-Phenotype Associations	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44061
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921828
(+)-isoprenaline-3046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
receptors	Phosphosite Textmining Biological Term Annotations	1.0	null
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947974
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SKMEL1	CCLE Cell Line Gene CNV Profiles	1.0	2.68286
Prestwick-665-2186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GLUTETHIMIDE	DGIdb Drug Targets 2026	1.0	0.031451
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5471
alpha	GeneRIF Biological Term Annotations	1.0	null
Anorexia Nervosa	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE133516_0_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
Diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.831
KYSE410	DepMap CRISPR Gene Dependency	1.0	2.18702
STRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57663
KYSE520	DepMap CRISPR Gene Dependency	1.0	4.5772
BRD-K06537903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31342
HPCAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5215
patch-clamp-techniques	Phosphosite Textmining Biological Term Annotations	1.0	null
SLR25	CCLE Cell Line Gene Expression Profiles	-1.0	-2.74024
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88244
respond	GeneRIF Biological Term Annotations	1.0	null
BRD-K19011391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61873
Distal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
AFF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34457
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4741	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35613
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.204923
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.843154
excitability	GeneRIF Biological Term Annotations	1.0	null
arrhythmia	GWASdb SNP-Phenotype Associations	1.0	0.164252
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907703
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21891
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
psych	GAD High Level Gene-Disease Associations	1.0	0.300704
EMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87629
WFDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54207
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16542501-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.047807
RIMS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36719
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.917306
Progesterone	CTD Gene-Chemical Interactions	1.0	null
Methoxyflurane	DrugBank Drug Targets	1.0	null
FANCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61137
BRD-K67484361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14927
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32849
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Primidone	HMDB Metabolites of Enzymes	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.381432
VARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70785
Rett syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1581
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26389
Perturb_4743_KD_Rpap1_SRP071014	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE94011_2_v_1_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61078
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71234
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
clemizole-2339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-539	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
MFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64608
HT3	DepMap CRISPR Gene Dependency	1.0	2.02432
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.548583
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02451
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13009
TATDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.065
THNSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32999
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GLI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62711
Fibre tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03204
Ventral posterolateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16836
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.38345
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1689
ESRRG_Deficiency_GDS2811_637_mouse_Fetal heart - Heterozygous null mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Gilles de la Tourette syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60595
PSMA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21917
predisposition	GeneRIF Biological Term Annotations	1.0	null
Morphine addiction	KEGG Pathways 2026	1.0	null
increased body weight	GWASdb SNP-Phenotype Associations	1.0	0.849662
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897778
ARF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56127
NCI-H1869	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE67266_7_v_4_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Leading edge membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
valproic acid_homo sapiens_gpl96_gds1050	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PGRMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44549
CLPP_KO_GSE40207_381_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
chloride channel activity	GO Molecular Function Annotations 2023	1.0	null
hsa-miR-3664-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K83567669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06959
adolescence-adult electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38149
neurosteroids	GeneRIF Biological Term Annotations	1.0	null
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEMAZEPAM	DGIdb Drug Targets 2026	1.0	0.0729091
BRD-K99529078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15698
AGBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25004
BRD-K42511168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1488
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18662
HMCB	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03535
DAOY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02031
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66351990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12221
GSE202434,GSE202438_7_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42479
ventral tier of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26269
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54523
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.119
BRD-K12955049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53613
PMC8421368-41598_2021_97059_MOESM3_ESM.xlsx-Genesets-GSC_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04706894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11877
applications	GeneRIF Biological Term Annotations	1.0	null
BRD-K75038426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01831
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41076
GSE237666,GSE237688_1_v_2_igf2bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLNS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08206
molecules	GeneRIF Biological Term Annotations	1.0	null
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
Tremor	CTD Gene-Disease Associations	1.0	1.43837
OSGEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07692
agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.177576
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.04615
related	GeneRIF Biological Term Annotations	1.0	null
MAPK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65099
TXNL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34297
Childhood absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
hsa-miR-3922-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
BRD-K31059159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69294
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6729
hsa-miR-548c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Psychotic disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
PHF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82433
BRD-K96807219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61203
dorsolateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11004
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Mesocorticolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
FN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82375
EVT 201	DGIdb Drug Targets 2026	1.0	0.0281403
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851768
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32053
abnormal leukocyte count	GWASdb SNP-Phenotype Associations	1.0	0.378591
PHENOBARBITAL	DGIdb Drug Targets 2026	1.0	0.0289009
Disease Models, Animal	HuGE Navigator Gene-Phenotype Associations	1.0	null
ALDH9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57535
EZH2	ENCODE Transcription Factor Targets	1.0	null
BREXANOLONE	DGIdb Drug Targets 2026	1.0	0.0668333
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855243
Rif1_KD_GDS4943_242_mouse_J1 embryonic stem cell (ESCs) line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3709
Prostate adenocarcinoma_PRAD_TCGA-VP-A87J-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuroactive ligand receptor interaction	KEGG Pathways	1.0	null
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Locus ceruleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.996243
Respiration Disorders	CTD Gene-Disease Associations	1.0	1.05757
hsa-miR-4642	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.981798
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25886
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.211823
hsa-miR-382	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
ZSCAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30356
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34056
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JW-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phosphorylation	GeneRIF Biological Term Annotations	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16223
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rifamycin-sv	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41196
GMPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46566
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43898
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60035
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64264
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glycopyrronium bromide-2565	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18371
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GATA5_GATA5	Rummagene Transcription Factor Associations 2026	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040482
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.02365
PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
cyproterone-6124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
L-363	GDSC Cell Line Gene Expression Profiles	1.0	2.12361
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.834097
RAD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16394
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30937
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67512
hsa-miR-4252	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
hsa-miR-3663-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3189
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75155
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00607
Dystonia	CTD Gene-Disease Associations	1.0	1.12426
PGBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3781
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05331
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00546
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	3.24903
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
AADAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33298
intermediate stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21312
r2 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15955
GSE137914_2_v_1_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07397
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.60967
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32818
Paralysis	CTD Gene-Disease Associations	1.0	1.16368
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pkc-dependent	Phosphosite Textmining Biological Term Annotations	1.0	null
HDAC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03569
VPS9D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75877
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.893212
GABA A receptor activation	Reactome Pathways 2014	1.0	null
mRNA_OTX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.982859
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0045
Flumazenil	CTD Gene-Chemical Interactions	1.0	null
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tonic	GeneRIF Biological Term Annotations	1.0	null
PSMD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66364
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4805
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2949
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4846
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.941072
RESEQUINIL	DGIdb Drug Targets 2026	1.0	0.0334167
ion channel complex	GO Cellular Component Annotations 2015	1.0	null
abnormal touch/ nociception	MPO Gene-Phenotype Associations	1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.00308
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2893
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26955
hsa-miR-544	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
USF1	ENCODE Transcription Factor Targets	1.0	null
Perturb_14972_KO_Max_SRP225905	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.1142
ADAM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41879
DIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19186
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998918
ZNF770	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52011
ZNF57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19387
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.07149
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878681
inhibitory synapse assembly	GO Biological Process Annotations 2025	1.0	null
diethylstilbestrol-2567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.50333
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15362
HOXD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18955
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.40347
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846813
SPEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96379
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K89742282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41187
JVM3	CCLE Cell Line Gene Expression Profiles	1.0	1.39201
BRD-K65891102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.08147
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834425
FOS	ENCODE Transcription Factor Targets	1.0	null
Amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.854
gabre	GeneRIF Biological Term Annotations	1.0	null
BRD-K64531971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44249
DHRS4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3019
MRPL50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5621
BRD-K78344913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14446
BRD-K28488100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04729
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51836
abnormality of myeloid leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.19521
BRD-K74968522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34991
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0316
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95629
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
neuron projection	GO Cellular Component Annotations 2023	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0592
CLORAZEPATE DIPOTASSIUM	DGIdb Drug Targets 2026	1.0	0.0334167
19303107-Table3	GeneSigDB Published Gene Signatures	1.0	null
Glutamate decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
POLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.25083
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57648
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3734
BRD-K92431275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57784
chloride transport	GO Biological Process Annotations 2025	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7339
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
periventricular stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07932
BRD-K62294866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65124
BRD-K76672145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20808
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.911359
BRD-K31778735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91677
synaptic transmission, GABAergic	GO Biological Process Annotations 2023	1.0	null
FBXL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8536
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.974
Butalbital	DrugBank Drug Targets	1.0	null
Taste transduction	KEGG Pathways 2026	1.0	null
Ventral posteromedial nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76025
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831943
hsa-miR-633	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
BRD-K38904629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33941
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37366
hsa-miR-3689d	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
BRD-K14383477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5272
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1998
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03659510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0413
Perturb_7080_KO_Hif1a_SRP300902	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.39572
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13319
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PSN1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73266
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989128
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67025
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
Presynaptic cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.521
EBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46144
Lung squamous cell carcinoma_LUSC_TCGA-77-8145-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.884577
Cell projection membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
medial part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12126
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC11554977-40199_2024_523_MOESM2_ESM.xlsx-Sheet1-Supplement_2_Metformin_Drug_Sensitivity_and_Damaging_Mutation_by_using_PRISM_Repurposing_Primary_Screen_and_Damaging_Mutation_in_DepMap_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
CALM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19596
hsa-miR-4461	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4239
adrenosterone-3107	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1929
mRNA_ETV3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
FLURAZEPAM	DGIdb Drug Targets 2026	1.0	0.0534667
PMC4496795-srep12063-s2.xls-STAT1_subnetwork-Gene_symbol_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.706
mantle zone of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00604
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Butethal	HMDB Metabolites of Enzymes	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13279
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47092
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923125
BRD-K63579322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51484
NSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65129
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0405
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43654
CRCGN015_MCF10A.TP53.M_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4901
dendrite	GO Cellular Component Annotations 2023	1.0	null
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04618
BRD-K10707948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38813
CRCGN017_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11458
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05054
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57517
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.879985
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47428
Fetalliver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.60052
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.33089
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4659b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
posterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2034
GSE67266_5_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03884263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18099
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.71
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.844265
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.960602
BRD-K25757224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39304
Subparafascicular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12884
BRD-K62152527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29833
CEBPB	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08953
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06403
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833927
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.157
etynodiol-3102	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11990377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09413
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7069-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54265757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54312
pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180937
JIMT1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91943
theobromine-2995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.37142
econazole-2396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GSE188570,GSE188571_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.15899
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930082
GAMG	CCLE Cell Line Gene CNV Profiles	1.0	1.3529
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7688
CLIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59221
superficial stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16635
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DYNLT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32025
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KCNK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0095
Butabarbital	HMDB Metabolites of Enzymes	1.0	null
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36922
duodenum_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.861285
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2854
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU410	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12344
AKIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7062
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LOREDIPLON	DGIdb Drug Targets 2026	1.0	0.0334167
BRD-K28924192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4578
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00562490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11507
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reduced	GeneRIF Biological Term Annotations	1.0	null
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K17854062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70586
PAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36064
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8042
MOLM13	DepMap CRISPR Gene Dependency	1.0	4.09429
BRD-K15928912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41851
DIAZEPAM	DGIdb Drug Targets 2026	1.0	0.0184368
CLDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50966
HOXB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94591
POLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4965
Pain	CTD Gene-Disease Associations	1.0	1.90308
BRD-K21443215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31035
XPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30082
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07177
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.905
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18914
PLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73913
COPS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49322
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37575
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transmitter-gated monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50758
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61785
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45635
Perturb_13869_KO_LIN28B_SRP284310	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.987341
BRD-K65729622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10747
BRD-K55479099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5222
hsa-miR-3150a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
intermediate stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25756
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29631
(+/-)-catechin-3012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03268
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SNU601	DepMap CRISPR Gene Dependency	1.0	2.50742
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32268
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
TSTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59125
hsa-miR-4427	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42999
lateral part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16595
ZNF551	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73601
kaempferol-6157	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36896
PMC6813882-NIHMS1526297-supplement-2.pdf-13-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
SHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38561
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bromazepam	DrugBank Drug Targets	1.0	null
putamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02792
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
TMEM74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7468
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
STK33_SKM	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00946
Cholinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.409
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
risk	GeneRIF Biological Term Annotations	1.0	null
GABA receptor activity	GO Molecular Function Annotations 2023	1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.996127
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8254
HUH6	CCLE Cell Line Gene Expression Profiles	1.0	1.35194
hsa-miR-4475	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
NITRAZEPAM	DGIdb Drug Targets 2026	1.0	0.0509206
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K78596805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11782
BRD-K48188521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3742
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75762
receptor activity	GO Molecular Function Annotations 2015	1.0	null
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
placenta_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.1349
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16367
MARCHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38745
ethotoin-2196	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.217
hsa-miR-4270	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K26620362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04681
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
LOU-NH91	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supraventricular arrhythmia	GWASdb SNP-Phenotype Associations	1.0	0.443881
THEM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88385
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.322
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05135
ZNF594	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50988
DPP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6784
posterior paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24167
Somatosensory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MGAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5328
NOMO1	CCLE Cell Line Gene Expression Profiles	1.0	1.75513
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14672
PTP4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81906
EPB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53089
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1777
gaboxadol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K26543702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54191
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841765
chloride transport	GO Biological Process Annotations 2015	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIN87	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40371
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
r2 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17051
Ion channel transport	Reactome Pathways 2014	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.46878
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.47648
inorganic anion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40539
ATXN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86719
BRD-K91241684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21218
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.939
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.78231
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prazepam	DrugBank Drug Targets	1.0	null
hsa-miR-4656	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.1456
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66004
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
begins	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4635	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ADAM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80357
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0264
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834967
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Chlorides	CTD Gene-Chemical Interactions	1.0	null
intermediate stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00377
no abnormal phenotype detected	MGI Mouse Phenotype Associations 2023	1.0	null
Halazepam	DrugBank Drug Targets	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00682
QUAZEPAM	DGIdb Drug Targets 2026	1.0	0.0267333
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.252
monoatomic anion channel activity	GO Molecular Function Annotations 2025	1.0	null
GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.734