association	dataset	threshold value	standardized value
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.416521
NKX3-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25469
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.943213
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32573
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
SF172	CCLE Cell Line Gene CNV Profiles	1.0	2.48365
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
A1207	Achilles Cell Line Gene Essentiality Profiles	1.0	1.38223
ZFAND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31598
monoatomic anion channel activity	GO Molecular Function Annotations 2025	1.0	null
HEC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.63507
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9565
MBTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93107
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66591
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Subthalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
PMC7913835__F3	PFOCR Pathway Figure Associations 2024	1.0	null
NEUROG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3039
HYLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30153
PGBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28769
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2034
Schizoaffective disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
PSMB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08615
Sarcoma_SARC_TCGA-VT-A80J-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.60789
ABCB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94365
Gamma-Aminobutyric acid	HMDB Metabolites of Enzymes	1.0	null
PMC9495000__F6	PFOCR Pathway Figure Associations 2024	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06247
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065747
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABA receptor activity	GO Molecular Function Annotations 2023	1.0	null
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9933
CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55012
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CD-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INHBE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72965
ZNF273	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04424
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.58286
Brain Lower Grade Glioma_LGG_TCGA-HT-8563-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87709
HCC15	CCLE Cell Line Gene Expression Profiles	1.0	1.43857
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
External side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09221
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67626
chloride transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1567
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3738
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
single organism signaling	GO Biological Process Annotations 2015	1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41468
CTNND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73377
C11orf71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18014
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.992377
gamma-aminobutyric acid signaling pathway	GO Biological Process Annotations 2025	1.0	null
GID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47758
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935254
CERS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57571
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.95
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3394
CAL62	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1532
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0871
gamma-Aminobutyric Acid	CTD Gene-Chemical Interactions	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844964
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11653
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63T-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2ME-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5358-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell communication	GO Biological Process Annotations 2015	1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.905487
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12505
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6709
5-ME-IAA	DGIdb Drug Targets 2026	1.0	0.45241
SLC25A27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92626
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8738
AURKAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83564
medial intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.882268
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04065
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	7.2941
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890846
MCM3AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41451
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8638-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3725
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2413
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.046
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.178129
major depressive disorder	GWASdb SNP-Disease Associations	1.0	0.770703
Essential tremor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.942
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.48019
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1329
CDCA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38089
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4666
ARRDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16112
CTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18154
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01545
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1-alkyl-2-acetylglycerophosphocholine esterase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.636
CORL24	CCLE Cell Line Gene CNV Profiles	1.0	1.44867
CLTC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36805
SKIC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.82674
CTAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61345
NMCG1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24243
STAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03886
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65131
piperidine-4-sulphonic acid	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05648
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84295
INPP5J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56157
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8673
FEM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21144
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994523
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIF13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.91178
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE2Q1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55295
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8692
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.0095
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5965
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11068
NDEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44847
TCF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42684
MNX1-26342078-MIN6-4N-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6471-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NITRAZEPAM	DGIdb Drug Targets 2026	1.0	0.12926
PIP5KL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00767
PRIMPOL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07527
KLF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42446
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56705
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BLACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77476
SIPA1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1171
GSE186647,GSE217288_2_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3665
ZC3H10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76665
NCI-H2066	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.854
GABA A (rho) receptor activation	Reactome Pathways 2014	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NYNRIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31919
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-11A-01R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF516	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13616
all	GWASdb SNP-Phenotype Associations	1.0	0.031663
ZSWIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32433
LIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6552
gaba receptor activity	GO Molecular Function Annotations 2015	1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4103-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.02548
TRIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33316
PLBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25588
SARS-ddORF6_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52774
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14512
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58
Clobazam	HMDB Metabolites of Enzymes	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4969
C18orf32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51478
superior parietal lobule, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.955487
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69441
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67584
CARM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31956
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02722
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9078
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GLRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35653
Quazepam	DrugBank Drug Targets	1.0	null
Gamma-aminobutyric acid A receptor/Glycine receptor alpha	InterPro Predicted Protein Domain Annotations	1.0	null
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28904
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52662
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11378
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
GABA receptor activation	Reactome Pathways 2024	1.0	null
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002119
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74836
PMC12534504-41598_2025_20489_MOESM1_ESM.pdf-326-GSC2_GSC2	Rummagene Transcription Factor Associations 2026	1.0	null
TBPS	DGIdb Drug Targets 2026	1.0	0.0714332
STX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38742
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0981
BSDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99994
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Triazolam	DrugBank Drug Targets	1.0	null
mood disorder	GWASdb SNP-Disease Associations	1.0	0.425285
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.424463
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.992
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4933
BCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6993
picrotoxinin	CTD Gene-Chemical Interactions	1.0	null
ARPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02169
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5701-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Restless legs syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.431
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5554
TEMAZEPAM	DGIdb Drug Targets 2026	1.0	0.123385
EMSY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12741
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1785
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.3533
H3K27me3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLOBAZAM	DGIdb Drug Targets 2026	1.0	0.123385
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7885-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.559
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31866
ABCG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51013
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913508
ANXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60872
CAL851	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54314
Zinc	CTD Gene-Chemical Interactions	1.0	null
processing	GeneRIF Biological Term Annotations	1.0	null
GABA receptor activation	Reactome Pathways 2014	1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062068
NALM6	Achilles Cell Line Gene Essentiality Profiles	1.0	1.40486
EIF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37399
LC-1-SQ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GALR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10018
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4481
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
either	GeneRIF Biological Term Annotations	1.0	null
TBPS	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
anterograde trans-synaptic signaling	GO Biological Process Annotations 2023	1.0	null
SLC41A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57976
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863287
SUPB15	CCLE Cell Line Gene Expression Profiles	1.0	2.52657
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M059J	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851916
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE165274_1_v_2_poldip2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61466
NCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85145
BCL11A_01_09	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59251
ZNF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03702
(±)-<i>cis</i>-2-CAMP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
ZCCHC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12693
RECQL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55327
FLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03436
NKAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08542
LN340	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45694
CGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36184
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.31314
Pancreatic adenocarcinoma_PAAD_TCGA-RB-A7B8-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12934
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7036
GABOXADOL	DGIdb Drug Targets 2026	1.0	0.0798371
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.04973
MTARC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71444
TGM2_KD_GSE23702_716_human_NB4 cells, 72h ATRA-induced differentiation	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
JPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.522
transmembrane transporter complex	GO Cellular Component Annotations 2015	1.0	null
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
PRSS50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89655
ASPC1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.19944
RTKN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.196
RD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99017
Harderian gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914651
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.00547
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6516-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hemoglobin a, glycosylated	GAD Gene-Disease Associations	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15094
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8863
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MIDAZOLAM HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.077556
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06247
SP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.292
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4021
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25378
biological regulation	GO Biological Process Annotations 2015	1.0	null
FAM118A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11852
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40118
LN443	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.17813
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0462
ALDOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53639
IDI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66847
DIAZEPAM	DGIdb Drug Targets 2026	1.0	0.0936021
4-aminocrotonic acid	CTD Gene-Chemical Interactions	1.0	null
PES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90457
Inferior olivary nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
CASC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99138
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UNKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25612
MTMR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0549
PPP4R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99914
SP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828349
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.13503
MAFF	ENCODE Transcription Factor Targets	1.0	null
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
isonipecotic acid	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77976
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.918
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.366856
Fludiazepam	DrugBank Drug Targets	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0679
AKNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14372
B800-820 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
Prazepam	DrugBank Drug Targets	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.988495
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38337
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9431
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PIK3CD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26705
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.76011
OC314	CCLE Cell Line Gene Expression Profiles	-1.0	-1.99454
TCIRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60988
GABAergic synapse	KEGG Pathways 2026	1.0	null
PICROTOXIN	DGIdb Drug Targets 2026	1.0	0.05901
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
KHK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44642
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31937
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38133
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5671-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8637
SKMM2	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.08077
PLAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3304
TUHR4TKB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57732
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2649
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9656
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.7631
inferior frontal gyrus, triangular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.964694
OELE	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.81872
PARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23991
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.071822
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFYVE16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34811
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3RK-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRANS-3-ACPBPA	DGIdb Drug Targets 2026	1.0	0.45241
HAUS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26451
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054097
synapse part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4728-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.089
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0615
MEOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54366
GSE113221,GSE113968_4_v_1_prdm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
thyroid	GTEx Tissue Gene Expression Profiles	1.0	0.920041
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70295
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914651
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14235_KO_Tet1_SRP237910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.14641
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
AMMECR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8697
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.66177
DNAJC28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59578
Perturb_15784_KO_Mef2d_SRP047079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.81799
GSE178714_6_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5423
C2CD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26402
GRHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36904
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9467
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0023
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26492
INAVA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80292
TYW3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89997
EIF3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23091
DAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36796
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899947
SKI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43665
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02496
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Medulloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913508
MFE280	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1081
TGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4396
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
Dmbx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4875
CAL27	CCLE Cell Line Gene CNV Profiles	1.0	1.51327
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-11A-02R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2472
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.871
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3Z-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43369
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HALAZEPAM	DGIdb Drug Targets 2026	1.0	0.135723
synaptic membrane	GO Cellular Component Annotations 2015	1.0	null
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.369
mRNA_STAT3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
RPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75851
SEC61G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31311
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20821
Temazepam	HMDB Metabolites of Enzymes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6996-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98278
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.4428
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anion transport	GO Biological Process Annotations 2015	1.0	null
Triazolam	HMDB Metabolites of Enzymes	1.0	null
Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	Reactome Pathways 2014	1.0	null
S1PR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66414
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.926886
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8196
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cell part	GO Cellular Component Annotations 2015	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7474-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39573
DYNC2I2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05314
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
CAL62	CCLE Cell Line Gene CNV Profiles	1.0	1.77422
ORAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27913
cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CMTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93789
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55449
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gaba-a receptor activity	GO Molecular Function Annotations 2015	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15898
EZH2	ENCODE Transcription Factor Targets	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054555
allelic	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8416-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66292
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2713
Kidney Chromophobe_KICH_TCGA-KM-8443-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7101-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16015
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A1KW-01A-22R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6051
BMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60462
MUTYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57891
SLC38A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44239
Estazolam	DrugBank Drug Targets	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07787
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Oviductal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Essential Tremor	DisGeNET Gene-Disease Associations	1.0	null
HNRNPUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88645
EFM19	Achilles Cell Line Gene Essentiality Profiles	1.0	1.25823
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050712
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.0324
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4073
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
Endopeduncular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.512
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
C2orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60171
TAL1	ENCODE Transcription Factor Targets	1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4759
FES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86586
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20536
angular gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881063
outer SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83429
NPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40049
KANSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66098
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43401
PATU8988S	CCLE Cell Line Gene Expression Profiles	1.0	1.96797
JHH-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ATP5PF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46193
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.031719
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	179.002
PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.7851
transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.005336
ABHD17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77244
STX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52375
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8399
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0905
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15876
visual	GeneRIF Biological Term Annotations	1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9962
KIAA2013	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39595
ZNF83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3352
PDLIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83479
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50529
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
significant	GeneRIF Biological Term Annotations	1.0	null
Neurotransmitter receptors and postsynaptic signal transmission	Reactome Pathways 2024	1.0	null
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899947
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0829
NCI-H838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28451
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
channel activity	GO Molecular Function Annotations 2015	1.0	null
Clorazepate	HMDB Metabolites of Enzymes	1.0	null
BRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17091
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3049
ATP6V1C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92968
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.933651
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
QUAZEPAM	DGIdb Drug Targets 2026	1.0	0.135723
NEURL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93787
lateral hypothalamic area, tuberal part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994341
CPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31497
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	2.4345
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENSG00000284691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37989
Perikaryon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
frequencies	GeneRIF Biological Term Annotations	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2549
KDM5A	ENCODE Transcription Factor Targets	1.0	null
CCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52076
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
Bipolar Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1079
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0344
Perturb_15770_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11821
DCTN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.999
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	1.43518
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Halazepam	DrugBank Drug Targets	1.0	null
Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OPM2	Achilles Cell Line Gene Essentiality Profiles	1.0	1.02584
OXAZEPAM	DGIdb Drug Targets 2026	1.0	0.104402
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.89895
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9788
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.27896
isoguvacine	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.056
PC14	CCLE Cell Line Gene CNV Profiles	1.0	1.40749
Brain Lower Grade Glioma_LGG_TCGA-DU-6408-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41493
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.056
COA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39842
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Neuroactive ligand signaling	KEGG Pathways 2026	1.0	null
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.932565
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	1.7905
SET2	CCLE Cell Line Gene Expression Profiles	1.0	1.65078
RAB3IL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08406
KIF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24287
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16215
HCC95	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32106
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08896
RNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52634
TMEM265	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58542
HL60	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.30615
CRO-AP3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11632
ADAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69398
genotypes	GeneRIF Biological Term Annotations	1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84458
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20512
LN464	Achilles Cell Line Gene Essentiality Profiles	1.0	2.14051
HEPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55673
SW1417	Achilles Cell Line Gene Essentiality Profiles	1.0	1.866
BRCA1_DEPLETION_GDS3791_502_human_Hela cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.385
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3368
TE9	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37687
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.06954
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RPL36A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20476
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
TMEM86B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54581
E2F4	ENCODE Transcription Factor Targets	1.0	null
PMC8638098__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
DROSHA	ChEA Transcription Factor Targets	1.0	null
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	2.88998
Oxazepam	DrugBank Drug Targets	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8144
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56664
VDAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07988
Nitrazepam	HMDB Metabolites of Enzymes	1.0	null
ZFAND2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08757
LTC4S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11108
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67543
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1664
L33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92653
SNUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.42947
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDUFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58059
HOXA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40803
sw13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.50108
receptors	GeneRIF Biological Term Annotations	1.0	null
MMS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09281
ML1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41604
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.852145
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29508
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68891
cell junction	GO Cellular Component Annotations 2015	1.0	null
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41528
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A375	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF185	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85169
PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
PJA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03938
DUSP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95905
SERPINE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45145
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56627
RHOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92174
ACSM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56222
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45986
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2196	CCLE Cell Line Gene CNV Profiles	1.0	1.49919
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0232
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54219
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30982
ZNF569	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61592
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.867208
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4481
KRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87305
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00135
GABA-ergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.698
LGR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36066
18689800-TableS8	GeneSigDB Published Gene Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MR-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SURF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14033
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7256
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5434-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUMF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77885
H3K27me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935956
ASPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10596
TRIM16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18511
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
LS-513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STK11IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82033
GET4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27982
uterus	GTEx Tissue Gene Expression Profiles	-1.0	-0.953931
AXIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64663
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5329
MKKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32175
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41305
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844131
integral component of postsynaptic membrane	SynGO Synaptic Gene Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HYAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24503
ZNF165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82618
gabrr1	GeneRIF Biological Term Annotations	1.0	null
Restless Legs Syndrome	DisGeNET Gene-Disease Associations	1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.82878
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
neuron projection	GO Cellular Component Annotations 2023	1.0	null
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8679
TP63	ChEA Transcription Factor Targets	1.0	null
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
FOXF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11879
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.937349
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878572
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40376
AMER1_OE_GDS4802_549_human_HEK293	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
KYSE450	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01011
MCAS	CCLE Cell Line Gene Expression Profiles	1.0	1.77376
transport	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6474-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48565
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23198
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.09841
RAPGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68867
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CORL51	CCLE Cell Line Gene Expression Profiles	1.0	1.35416
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32573
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23097
ATM_KD_GSE54268_663_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MTIF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91069
OCINAPLON	DGIdb Drug Targets 2026	1.0	0.0714332
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.968541
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8002-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
artery disease	GWASdb SNP-Disease Associations	1.0	0.08565
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17902
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20H-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15237
hypertension	GWASdb SNP-Disease Associations	1.0	0.496801
REST_01_337	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63367
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7048
Perturb_971_OE_SRSF1_SRP174924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.35715
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13974
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32933
CTCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87656
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6629
Auditory capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
synapse	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
synaptic membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9243
Prostate adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
REMIMAZOLAM	DGIdb Drug Targets 2026	1.0	0.0678615
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2011
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1273
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4891
PRAZEPAM	DGIdb Drug Targets 2026	1.0	0.123385
OSGIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8505
ASMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90936
ATXN7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36515
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gabrr1m26v	GeneRIF Biological Term Annotations	1.0	null
ZNF316	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07843
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.07505
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.902888
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040661
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ligand-gated monoatomic anion channel activity	GO Molecular Function Annotations 2025	1.0	null
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.870392
SK-GT-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF429	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04931
CCDC103	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5438
SLC25A28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53671
GSE95771_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POU5F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15233
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7649-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.92072
GAK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF432	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47735
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.55879
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
TIGD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75784
NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84082
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.976132
SF3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66844
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
inorganic anion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
SKMEL5	Achilles Cell Line Gene Essentiality Profiles	1.0	1.13952
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25147
KLHL42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82821
NOMO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.08171
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.04838
Adinazolam	HMDB Metabolites of Enzymes	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8454
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q3-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6253
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
SDR42E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67323
binding	GO Molecular Function Annotations 2015	1.0	null
BRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98095
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5907
ARHGAP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50784
TMEM208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65989
Diazepam	DrugBank Drug Targets	1.0	null
EBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25V-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SKNDZ	CCLE Cell Line Gene Expression Profiles	1.0	1.53066
Transmission across Chemical Synapses	Reactome Pathways 2024	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06751
Rectal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
SUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43833
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1672
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26968
PLB985	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.67812
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3704
MOSPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.55949
<i>cis</i>-3-ACPBPA	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
RPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73186
Hereditary nonpolyposis colorectal cancer type 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
AASDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95252
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WS-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7066
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47361
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1459
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3144
H3C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08863
CCDC74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69408
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7047
mental depression	GWASdb SNP-Disease Associations	1.0	0.451481
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.060935
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	149.603
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3313
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8407-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMBRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53316
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8978
SNU899	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56124
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34509
signal transduction	GO Biological Process Annotations 2015	1.0	null
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22841
RPRML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50076
Perturb_307_KD_TPRX1/TPRX2_SRP361145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57413
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
Ligand-gated ion channel transport	Reactome Pathways 2014	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WD-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22621
PROSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78656
GA10	CCLE Cell Line Gene Expression Profiles	1.0	2.3757
ALKBH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58052
ATP5MGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33349
medial parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.972049
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98311
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49064
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2968
PTPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31049
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.2865
RAB40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99315
Brain Lower Grade Glioma_LGG_TCGA-HT-A74O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIPERIDINE-4-SULPHONIC ACID	DGIdb Drug Targets 2026	1.0	0.150803
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28469
anion channel activity	GO Molecular Function Annotations 2015	1.0	null
NUDT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68578
ZNF596	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36412
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48774
L363	CCLE Cell Line Gene Expression Profiles	1.0	1.95508
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4929
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00785
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4637
Kidney renal clear cell carcinoma_KIRC_TCGA-GK-A6C7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLONAZEPAM	DGIdb Drug Targets 2026	1.0	0.123385
CRABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.153
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.417337
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26496
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0462
protein complex	GO Cellular Component Annotations 2015	1.0	null
STARD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29109
DST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42859
PPP3CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99827
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
496100464_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.4553
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4321
HNRNPK_02_91	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.72792
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4785
MXI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.24138
MFAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33767
ZNF48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73525
disease	GWASdb SNP-Disease Associations	1.0	0.029764
Ion channel transport	Reactome Pathways 2014	1.0	null
l35	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9512
BUB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15915
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054207
SLC38A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44157
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.8
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6083
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052932
ZNF792	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60296
chloride channel complex	GO Cellular Component Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-LI-A67I-01A-31R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.967433
C3orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82378
h27r	GeneRIF Biological Term Annotations	1.0	null
GSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09111
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72974
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914651
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B2-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7243
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
LIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59108
MON2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66044
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.99314
FBXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06321
Neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BLMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68621
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-3.3165
NCI-H3122	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AQP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18579
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CIS-3-ACPBPA	DGIdb Drug Targets 2026	1.0	0.45241
DROSHA-22980978-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6654
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2538
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4432
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65996
MYB-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GABA receptor complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.80877
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82157
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2877
RALB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53796
ZER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15763
TPCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.185
dg1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.90803
SUGP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89408
mRNA_SMAD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8406-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.96987
ADIPIPLON	DGIdb Drug Targets 2026	1.0	0.0714332
ZNF865	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52954
CCDC71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71889
POLR2J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65631
rat	GeneRIF Biological Term Annotations	1.0	null
RAC3-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935254
Retrograde endocannabinoid signaling	KEGG Pathways 2026	1.0	null
CINOLAZEPAM	DGIdb Drug Targets 2026	1.0	0.159674
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04102
ITPRIPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07869
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.32041
FOXE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05868
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05071
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MI-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02722
GABA-A receptor complex	GO Cellular Component Annotations 2023	1.0	null
U2AF2_02_105	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.82375
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6803
GABA-A receptor complex	GO Cellular Component Annotations 2025	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.883
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040146
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4521181-oncsis201520x8.pdf-112-SPDEF_SPDEF	Rummagene Transcription Factor Associations 2026	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.988495
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7913835__F3	PFOCR Pathway Figure Associations 2023	1.0	null
SUDHL4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.27581
<i>trans</i>-3-ACPBPA	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
STAT4	ChEA Transcription Factor Targets	1.0	null
ligand-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4809
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
TPMPA	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9161725-Table_4.xlsx-EHF-CSAG1_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM104	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94861
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LS513	Achilles Cell Line Gene Essentiality Profiles	1.0	1.70436
Prechordal mesendoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.109
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2151
STAT4-19710469-TH1 cell mouse-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4515
ZNF620	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07711
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
P4HTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40196
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1667
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03346
Perturb_305_KD_Pabpn1_SRP318863	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70591
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
496100341_TCx_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33223
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01142
SLC25A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90701
H3C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25486
EMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2273
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.695
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.21732
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831394
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07188
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
[3H]MUSCIMOL	DGIdb Drug Targets 2026	1.0	0.150803
MOGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30721
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Midazolam	DrugBank Drug Targets	1.0	null
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3671
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	1.74875
ZFTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67593
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76502
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0653
FAM220A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96487
DEPDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92539
OC315	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66485
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8929
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WU-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8333
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
specifically	GeneRIF Biological Term Annotations	1.0	null
MSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74546
Prostate adenocarcinoma_PRAD_TCGA-CH-5745-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRCA1	JASPAR Predicted Transcription Factor Targets	1.0	null
lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05292
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15763
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1071
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_Ref_Can-ZNF205_ZNF205	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32798
FBXO42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28174
EXOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94216
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844964
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9663
PMC9669639-mmc3.xlsx-NRLonly-degs-207-Single_cell_RNA-seq_differentially_expressed_genes_between_control_versus_USH1B_NRL_cells_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
Neuronal System	Reactome Pathways 2024	1.0	null
PRR29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57714
TGFBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82818
cellular process	GO Biological Process Annotations 2015	1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45425
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06904
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5370-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40513
RPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0462
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.48893
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301398
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.494
AMOTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17517
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95595
ROCK_INHIBITION_GDS3944_463_mouse_Forebrain astrocytes - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MYOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98166
DDX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52542
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.71339
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.500098
SKCO1	CCLE Cell Line Gene Expression Profiles	1.0	1.61171
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5387
chloride channel activity	GO Molecular Function Annotations 2025	1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HU-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Prostate adenocarcinoma_PRAD_TCGA-CH-5738-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCDHB15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71108
chemical synaptic transmission	GO Biological Process Annotations 2025	1.0	null
mRNA_ATF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2078
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0839
PGGT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35505
TMEM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.678
Sperm flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
POR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05624
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25563
ANKRD24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75331
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19357
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.03969
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.884885
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.2886
NIFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2431
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.94566
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4964-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABA-A receptor activity	GO Molecular Function Annotations 2025	1.0	null
ST6GAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38403
vascular disease	GWASdb SNP-Disease Associations	1.0	0.061931
differences	GeneRIF Biological Term Annotations	1.0	null
PRDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48561
TPRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81793
CNOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22574
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19643
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846056
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
RAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72729
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052563
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6003-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.44997
Estazolam	HMDB Metabolites of Enzymes	1.0	null
TEAD-YAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
placenta	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.888776
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958385
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844964
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_AES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
embryoday7.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.15903
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.988
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7289
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20821
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.3069
MTMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79309
mRNA_GADD45A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5506-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14241
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.848316
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2712
EIF4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47933
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09308
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4967-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRMT10C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57922
Anterior hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
RASGRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91374
gaboxadol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40118
ZW10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23988
GABA-A receptor complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72239
aspects	GeneRIF Biological Term Annotations	1.0	null
ANKRD30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35754
EDEM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36973
GH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61544
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3447
NCI-H2135	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
ISOGUVACINE	DGIdb Drug Targets 2026	1.0	0.150803
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14562
SMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69444
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE450	CCLE Cell Line Gene CNV Profiles	1.0	1.47124
inorganic anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03542
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18888
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3004
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42679
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.67965
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892749
Fascia dentata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2664
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
SACS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94904
chloride transmembrane transport	GO Biological Process Annotations 2015	1.0	null
COPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76905
Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11358
transporter complex	GO Cellular Component Annotations 2015	1.0	null
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72007
image	GeneRIF Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GE-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050712
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6962
AFG3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01472
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-466-HMGA2_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
TSSK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36081
Globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.905138
FLURAZEPAM	DGIdb Drug Targets 2026	1.0	0.135723
XIAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23656
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19487
Psychotic disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844964
SW1783	CCLE Cell Line Gene CNV Profiles	1.0	1.37406
NCIH1915	CCLE Cell Line Gene Expression Profiles	-1.0	-2.79838
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
bipolar disorder	GAD Gene-Disease Associations	1.0	null
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8544
Neurotransmitter-gated ion-channel transmembrane domain	InterPro Predicted Protein Domain Annotations	1.0	null
EFEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50445
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.4104
DYNC1LI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8316
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050619
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.98583
TJAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.14099
MYC	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7010-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936161
movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.730571
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4455
METTL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.293
chloride transport	GO Biological Process Annotations 2015	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.942462
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239007
UBE2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62849
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0714
TP53_01_175	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.50462
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1276
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.093
TNFAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73026
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2823
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6943-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10388
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCCSUP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.68355
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18888
mRNA_EED_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.168352
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.889088
Prazepam	HMDB Metabolites of Enzymes	1.0	null
MFSD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93614
IRF1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7754-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33034
MPDU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26784
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844964
BT-549	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lorazepam	HMDB Metabolites of Enzymes	1.0	null
ARFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23625
obsessive-compulsive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
496100548_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67022
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.86195
GPR62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22346
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.2781
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7228
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5031
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4112
Bromazepam	DrugBank Drug Targets	1.0	null
Cognitive disorder	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2924
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8545
AZA-THIP	DGIdb Drug Targets 2026	1.0	0.45241
receptor activity	GO Molecular Function Annotations 2015	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.798
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H820	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SMIM24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04497
CDK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03474
FNDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83312
HT55	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84097
RFX5	ENCODE Transcription Factor Targets	1.0	null
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.68952
Adinazolam	DrugBank Drug Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2899
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
DND41	CCLE Cell Line Gene Expression Profiles	1.0	2.0196
Prader Willi and Angelman syndrome	WikiPathways Pathways 2024	1.0	null
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
PNMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33087
SLC2A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97691
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8769
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
HS-578-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.879604
CSPG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15309
endogenous depression	GWASdb SNP-Disease Associations	1.0	0.770703
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07019
Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5632
TPMPA	DGIdb Drug Targets 2026	1.0	0.45241
Prostate adenocarcinoma_PRAD_TCGA-G9-6377-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nicotine addiction	KEGG Pathways 2026	1.0	null
SERHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37638
FOXN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4589
Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chloride transmembrane transport	GO Biological Process Annotations 2025	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1719
Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLOTIAZEPAM	DGIdb Drug Targets 2026	1.0	0.135723
GABA receptor activity	GO Molecular Function Annotations 2025	1.0	null
5-Me-IAA	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Adult fibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2249
Asthma_Epithelial Cell_GSE4302	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.6434
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.55587
GABA-gated chloride ion channel activity	GO Molecular Function Annotations 2025	1.0	null
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.935682
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943545
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.81964
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.24
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.396725
Neurotransmitter-gated ion-channel, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5624
supramarginal gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89395
EFM-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70365
gamma-aminobutyric acid signaling pathway	GO Biological Process Annotations 2023	1.0	null
HUNS1	CCLE Cell Line Gene Expression Profiles	1.0	1.69661
TRPM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84564
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1691
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.441
FAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39256
UNC5CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55219
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24033
Kenny-Caffey syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
RH30	CCLE Cell Line Gene CNV Profiles	1.0	1.4003
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57139
BORCS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12298
GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.586
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55827
ISONIPECOTIC ACID	DGIdb Drug Targets 2026	1.0	0.123385
KCNMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53731
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.95764
JUN_KO_GDS4205_294_mouse_B lymphoid cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8724
variants	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2295
RPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01296
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30527
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13125
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7762
496100306_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58816
mRNA_CTNNB1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Midazolam	HMDB Metabolites of Enzymes	1.0	null
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
RANGRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41423
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.21
PDGFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10115
Liver hepatocellular carcinoma_LIHC_TCGA-HP-A5MZ-01A-21R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
postsynaptic membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6053
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043062
COLO-800	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TNRC6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35136
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35546
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5533
ECHS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13298
RHOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14024
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.046783
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.789
SLITRK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9333
CRYBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11279
Pars reticulata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.161
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4966
Hemoglobin A, Glycosylated	dbGAP Gene-Trait Associations	1.0	0.321458
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16648
FOXA2	ChEA Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14025
CCDC51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60792
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50658
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6309
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.97524
ERCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34545
posterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1083
BACH1	ENCODE Transcription Factor Targets	1.0	null
Neurotransmitter-gated ion-channel ligand-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
Chlorine	HMDB Metabolites of Enzymes	1.0	null
ELMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99015
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15898
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12603
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3851
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.833977
SF126	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8393
SK-MEL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH2171	CCLE Cell Line Gene CNV Profiles	1.0	1.53468
Brain Lower Grade Glioma_LGG_TCGA-DU-7301-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059371
fallopian tube	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
FAAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02205
membrane part	GO Cellular Component Annotations 2015	1.0	null
RWDD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45785
several psychiatric disorders	GAD Gene-Disease Associations	1.0	null
CEP170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99639
PAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96702
MSGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76718
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.963486
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02584
NCI-H520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SEC14L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06658
GSE189772,GSE189773_0_v_5_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33256
LMX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52934
mania	GWASdb SNP-Phenotype Associations	1.0	0.426753
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10254
postcentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.898924
LIPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85294
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
HAPLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96248
GATA3_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1689
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19669
OAW-28	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LAMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59931
CRACR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02303
FLUDIAZEPAM	DGIdb Drug Targets 2026	1.0	0.159674
ASB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43285
BROMAZEPAM	DGIdb Drug Targets 2026	1.0	0.12926
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03262
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.83035
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE242290_1_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPRD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72365
GPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13528
NCIH82	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25374
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26429
NCIH1568	CCLE Cell Line Gene CNV Profiles	-1.0	-2.5577
monoatomic anion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8335-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bromazepam	HMDB Metabolites of Enzymes	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT4-19710469-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.47646
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tremor	GeneRIF Biological Term Annotations	1.0	null
LRRC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09783
brain	GeneRIF Biological Term Annotations	1.0	null
MIEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6612
PRRC2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03265
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7049
liver	GTEx Tissue Gene Expression Profiles	1.0	1.51982
CLORAZEPATE	DGIdb Drug Targets 2026	1.0	0.135723
Acute Myeloid Leukemia_LAML_TCGA-AB-2822-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04976
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8595
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FSTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08894
CTDNEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86074
picrotoxin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888751
RAD21	ChEA Transcription Factor Targets	1.0	null
PLAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84554
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4219
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
NCIH747	CCLE Cell Line Gene CNV Profiles	1.0	1.69356
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	1.77533
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69963
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7732
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2171
GSE65617_2_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C1QBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01492
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13136
CBP-20019798-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Morphine addiction	KEGG Pathways 2026	1.0	null
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4189
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2544
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NRDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1731
single-organism process	GO Biological Process Annotations 2015	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26503
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4246
MEIOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02753
Cinolazepam	HMDB Metabolites of Enzymes	1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6845
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100344_HIP_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.98225
Clotiazepam	DrugBank Drug Targets	1.0	null
GIPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29381
Sarcoma_SARC_TCGA-HB-A2OT-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscimol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
MZ in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39019
RERFLCAD2	CCLE Cell Line Gene Expression Profiles	1.0	1.7902
Flurazepam	HMDB Metabolites of Enzymes	1.0	null
PLAUR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60212
ZNF394	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49514
U251MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60918
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7154
NUP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04478
ZNF425	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25078
DNAAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69421
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77257
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06938
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.988026
DHX57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.307
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
inferior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36047
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22379
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0392
Brain Lower Grade Glioma_LGG_TCGA-QH-A65R-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cinolazepam	DrugBank Drug Targets	1.0	null
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97292
SNU1076	CCLE Cell Line Gene Expression Profiles	1.0	2.13029
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.1274
CZIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43536
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7357
HS172T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67295
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H2AX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96163
Neurotransmitter-gated ion-channel	InterPro Predicted Protein Domain Annotations	1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220152
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6478-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42008
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUP-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Flurazepam	DrugBank Drug Targets	1.0	null
CDKN2AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40793
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10686
Muscimol	CTD Gene-Chemical Interactions	1.0	null
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6332
SOX10_KO_GDS3480_257_rat_Schwannoma cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063693
ANKRD27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80227
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6954
PPIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11997
HS343T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62846
Nitrazepam	DrugBank Drug Targets	1.0	null
SLC35F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74933
TSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27181
PNPLA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38109
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4708
VASH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67166
KMS26	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56842
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02172
STAT3	ENCODE Transcription Factor Targets	1.0	null
BAMBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37152
RASD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31784
TMED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6597
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10254
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2857
UBXN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23421
ENTPD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.952
CSGALNACT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3238
ID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40117
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior frontal gyrus, orbital part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03289
SQSTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.21527
IRF4-20064451-CD4+T-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01003
SMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90931
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neuronal System	Reactome Pathways 2014	1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3139
NCIH1836	CCLE Cell Line Gene Expression Profiles	1.0	1.70974
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5463
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
KMRC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53542
TUHR10TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73547
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45379
ECC10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ANKEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35823
DHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73829
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
Schizoaffective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.438
H3K27me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7399-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21002
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.917801
Eye-retinal bipolar neuron	Tabula Sapiens Gene-Cell Associations	1.0	0.772678
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76253
Alpha-hydroxyalprazolam	HMDB Metabolites of Enzymes	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2375
LUC7L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61423
VDAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04634
Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878878
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0993
S100A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95286
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EVT 201	DGIdb Drug Targets 2026	1.0	0.0714332
chemical synaptic transmission	GO Biological Process Annotations 2023	1.0	null
NCI-H295R cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.347
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.50306
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32573
TACSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63082
aza-THIP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
POLR3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91454
RGPD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80031
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02295
WTX_OE_GDS4802_34_human_HEK293	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4731
MOLM6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46355
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925417
ESTAZOLAM	DGIdb Drug Targets 2026	1.0	0.11802
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20978
KRTCAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3673
KE97	CCLE Cell Line Gene Expression Profiles	1.0	1.91279
c-MYC_KD_GDS2526_113_human_MDA-MB-231 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
STAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.538
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Subpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1202
GATA3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
KHDRBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41066
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
Transmission across Chemical Synapses	Reactome Pathways 2014	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890846
MPP-89	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.905413
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33499
WTX_OE_GDS4802_325_human_HEK293 embryonic kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7459
STAT1_KD_GDS4754_159_human_JURKAT	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5709
RPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07444
chloride transport	GO Biological Process Annotations 2025	1.0	null
Perturb_6251_KO_Dicer_SRP041835	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SELENOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88073
precentral gyrus, right, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.0757
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gabrr2t455m	GeneRIF Biological Term Annotations	1.0	null
SK-N-SH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1283
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06251
Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAVS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43109
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.945817
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890846
CPLANE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60757
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49241
PGM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8565
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23129
CAL33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65548
Tear gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8182
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994523
ZNF426	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16954
Childhood osteosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FKBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96382
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31098
ODR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00772
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1852
TDGF1P3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28345
496100413_FWM_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	10.5201
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
786O	CCLE Cell Line Gene Expression Profiles	1.0	2.46251
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
IGR39	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.14062
(&PLUSMN;)-CIS-2-CAMP	DGIdb Drug Targets 2026	1.0	0.45241
LRR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2517
FKBPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37352
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00236
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8174
G3BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32539
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21239
embryoday9.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.05288
NDUFAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7873
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.929174
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53877
PLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94477
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.975656
HNF4A	ChEA Transcription Factor Targets	1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.2053
CAPAN-1	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.112
GPRASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78671
FOXRED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0079
MAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91023
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86531
KYAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02918
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.08758
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4982-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_MYCN_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Bone osteosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
LMF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26779
THY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1133
localization	GO Biological Process Annotations 2015	1.0	null
Quazepam	HMDB Metabolites of Enzymes	1.0	null
REH	Achilles Cell Line Gene Essentiality Profiles	1.0	1.36293
GATA3	ENCODE Transcription Factor Targets	1.0	null
synapse part	GO Cellular Component Annotations 2015	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.890846
WDR5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63597
signaling	GO Biological Process Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7647-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
postsynaptic membrane	GO Cellular Component Annotations 2015	1.0	null
anterograde trans-synaptic signaling	GO Biological Process Annotations 2025	1.0	null
YTHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11715
Prostate adenocarcinoma_PRAD_TCGA-HC-7210-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chloride transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.09452
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92937
TRIAZOLAM	DGIdb Drug Targets 2026	1.0	0.090482
cingulate gyrus, parietal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.963288
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6446
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935254
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3589
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6701
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2511
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.92
Lung squamous cell carcinoma_LUSC_TCGA-58-A46N-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60304
extracellular ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
H3K27me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE86507,GSE86509_3_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU423	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68729
Clonazepam	HMDB Metabolites of Enzymes	1.0	null
MAP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92043
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7639
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.426753
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12776
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05891
OARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53019
UCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29716
protein binding	GO Molecular Function Annotations 2015	1.0	null
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65965
RERFLCAD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5422
PDCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82919
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
SHISA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07408
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49241
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1617
CHL1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49907
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.413
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3155
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975248
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADINAZOLAM	DGIdb Drug Targets 2026	1.0	0.159674
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844212
ALPRAZOLAM	DGIdb Drug Targets 2026	1.0	0.090482
inorganic anion transport	GO Biological Process Annotations 2015	1.0	null
BXPC3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57606
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0462
DROSHA-22980978-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3159
essential tremor	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.22215
PHRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08546
ALG10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82563
transmitter-gated monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-SG-A6Z4-01A-22R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.44772
Disease of mental health	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55836
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8634-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.88181
KLF2_01_226	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.28801
CADOES1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.34033
SLC39A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40268
establishment of localization	GO Biological Process Annotations 2015	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.955096
JHH2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64116
SLC4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47843
MTURN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45116
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4349
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09156
LAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5308
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77711
HCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32674
SLFN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41334
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RW-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LENG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37492
GABA-A receptor activity	GO Molecular Function Annotations 2023	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35581
motion	GeneRIF Biological Term Annotations	1.0	null
U2AF1L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0357
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1715
FKBP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18413
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7556
HAPSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53655
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TT	CCLE Cell Line Gene CNV Profiles	1.0	2.09022
Temazepam	DrugBank Drug Targets	1.0	null
HIPK2_defectivemutant_29_GDS4233	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.80027
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
essential	GeneRIF Biological Term Annotations	1.0	null
gamma-aminobutyric acid signaling pathway	GO Biological Process Annotations 2015	1.0	null
USP13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52277
RNF34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28943
gabac	GeneRIF Biological Term Annotations	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15898
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.516
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34004
PDLIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32466
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43401
GSE58498,GSE58501_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU1272	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53767
protein domain specific binding	GO Molecular Function Annotations 2015	1.0	null
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
P2RX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83389
TCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21386
MIS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22488
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01262
PLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22457
MDAMB435S	CCLE Cell Line Gene CNV Profiles	1.0	1.40095
Mental Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
Perturb_14796_OE_Mycn_SRP094656	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88597
postcentral gyrus, right, bank of the posterior central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22235
single-organism localization	GO Biological Process Annotations 2015	1.0	null
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49946
RAD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2047
GATD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04696
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.3233
YAP_OE_GDS3220_32_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7432
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7516
depression	GWASdb SNP-Phenotype Associations	1.0	0.667971
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44589
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL6ST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89826
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913508
TMEM143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09036
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4949
DMS79	CCLE Cell Line Gene CNV Profiles	1.0	1.60166
CCDC115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20875
CD2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7299
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13765
chloride channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4959
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06904
CHLORDIAZEPOXIDE	DGIdb Drug Targets 2026	1.0	0.12926
TE441T	CCLE Cell Line Gene CNV Profiles	-1.0	-3.02954
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF217_OE_GDS4885_317_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Oxazepam	HMDB Metabolites of Enzymes	1.0	null
Clotiazepam	HMDB Metabolites of Enzymes	1.0	null
chloride channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.687
TAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43241
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0566
gabrr3y205x	GeneRIF Biological Term Annotations	1.0	null
FYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25731
Halazepam	HMDB Metabolites of Enzymes	1.0	null
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.771661
GSE114685_1_v_0_grin2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063272
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09168
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ISLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56203
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C5orf22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91183
NPIPB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31099
CMAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34481
Chlordiazepoxide	HMDB Metabolites of Enzymes	1.0	null
lateral orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06455
NCIH2122	CCLE Cell Line Gene Expression Profiles	1.0	1.42316
Fludiazepam	HMDB Metabolites of Enzymes	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.75618
Stereocilium tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.393
CACHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8053
DNPEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16697
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068685
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.847972
ING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61736
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1541
HSFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88967
ion channel complex	GO Cellular Component Annotations 2015	1.0	null
LORAZEPAM	DGIdb Drug Targets 2026	1.0	0.108578
schizoaffective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.64218
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.275444
ZNF679	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20459
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07149
KDM4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50468
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831754
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35307
GSU	CCLE Cell Line Gene CNV Profiles	1.0	2.00875
FKBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59126
TBC1D20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04308
CDHR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02044
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8917
frontal operculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45068