association	dataset	threshold value	standardized value
BRD-K39396484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48644
Extracellular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ME-11-OJ38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217014
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53355
BRD-K19817946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38544
PMC4290621-1471-2164-15-S9-S7-S12.xls-Sheet1-HOXD-AS1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51429
Kinetochore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.385
Signal recognition particle receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.06
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410167
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456278
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281945
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.773029
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.484
GSE203060_0_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TPGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13535
ATAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527464
BRD-K30055322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03403
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5913
CRCGN017_MCF10A.WT.HP_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3883
BRD-K68939871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05895
Gonadal sheath cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.158
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Becker disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.434
BCL11A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533227
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.98468
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73039647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64592
BRD-K72565671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48455
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221635
BRD-K44497547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66005
BRD-K22608982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63364
nucleolus	GO Cellular Component Annotations 2025	1.0	null
BRD-K25933460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5663
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8902
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46893
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.647
ADCK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25398
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2812
PMC3814363__F4	PFOCR Pathway Figure Associations 2024	1.0	null
EA-93-KT88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397474
BRD-K00767817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36351
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535852
Salivary gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5492
CNOT6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05835
BRD-K69367836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16888
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4341
BRD-K88038091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45678
RPLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12426
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.1644
IE-38-FB31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464971
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43119
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K03849840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20755
DB-41-IH69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222917
HF-67-IR57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219601
NRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.044
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9493
GC-86-TD91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209564
Salt gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233614
BRD-K83820627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17814
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30558628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48807
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59456
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.67365
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_AD1-STAT3_target_genes_predicted_by_CHIP-seq_overlap_with_genes_in_AD_M1_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
WDR74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48543
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5247
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07825644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06998
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02889
LB-90-DC89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281363
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
LA-10-VZ79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228439
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.027
BRD-K64992851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31152
MUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45251
Cuticular plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.877
BRD-K73364700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26285
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28226
DDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29201
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.351
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2805
BRD-K09308989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69234
SCN1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069821
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Helam	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
BRD-K87558616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12205
EC-71-PH39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370751
BRD-K76166595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74406
CE-18-AP15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36528
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83834
BRD-K54751293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64102
protein targeting to ER	GO Biological Process Annotations 2023	1.0	null
BRD-K54979104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71362
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07631
Intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
BRD-K36643302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23767
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plastid intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.687
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.1459
GSE226233_0_v_1_pccb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234514,GSE234516_1_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-31-VS31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244639
BRD-K53257131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65024
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432428
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Protein export	KEGG Pathways 2026	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1401
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A61778798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54162
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24309
EA-40-KQ08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231375
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249233
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04067194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3825
Plastid ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.874
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
BRD-K48592348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39163
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9473
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.604071
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203806
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.704437
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1044
BRD-K94516254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88775
Chondrodysplasia punctata	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258519
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11551338-pnas.2411189121.sd01.xlsx-FXR-Unnamed_0_NR1H4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92524823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73575
BRD-K78762661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86193
SEC31B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06354
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2093
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8631
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251273
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649695
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03695
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07813434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47337
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49325049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98362
BRD-A77328129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.124
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29659
BB-83-ZM06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292129
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07974
BRD-K71251432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11324
BB-65-SY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474389
PMC12646006-jvi.01535-25-s0002.pdf-3-ARNT_ARNT	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08558441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45623
EB-67-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24114
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63469
BRD-K56086519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32562
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0916
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43479
BRD-K14925361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35391
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytochrome b6f complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362887
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14344
ZD-78-BS65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431964
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.411
PB-40-CS17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234412
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.1672
BRD-K28641265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0609
Swim bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
SLC41A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57504
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EPHB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.004404
496100625_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10103
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.685
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465598
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.98
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298012
CCDC158	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628093
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09689
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25566
BRD-K11442063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59345
Gas bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
4953_MED30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06191
BRD-K25351976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42907
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K83125173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24752
GSE201042_6_v_7_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7518873-abb0205_Table_S1.xls-TFEB_targets-symbol_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
k562clones	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286795
BRD-K30977850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30966
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358349
AD-28-GJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250312
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PNGase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
ER ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
BRD-K06332513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17187
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.794977
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5129
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39203
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9869
PMC3557799__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.397
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.804
PMC8384902-mmc2.xlsx-4_NEUROD1_high_subtype-Gene_Symbol_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25977
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20158
BRD-K95810752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13399
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02222
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.0901
BRD-K08241590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18848
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130664
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05967
BRD-K37140349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26569
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393065
BRD-K87180723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24372
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409867
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1467
BRD-K10705624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48104
Endocytic patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0279
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12613826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64549
TF-43-DT71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32153
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.896
BRD-K90872016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13885
BRD-K25638876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05824
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
SB-29-ZH97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275122
BRD-K33037101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35784
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.862
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.78471
CF-61-EH59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429762
Very long chain acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
CRCGN015_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32792
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03624299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1744
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-52-UZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264232
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06058625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32564
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43611837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91996
Asi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
Hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.33
BRD-K21215763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30284
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157415
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.265
BRD-K68995447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30172
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208741
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7161
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157677
HD-26-KX74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482985
BRD-K20428189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42666
BRD-K29128208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16647
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312707
PDGFRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02876
BRD-K94411351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85403
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153068
BRD-K83012560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98364
BRD-K31021810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20866
BRD-K18519876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11669
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92766
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.428008
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PF-39-DY68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218094
PB-40-YB26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207703
TC-66-CI47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235988
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4415
Ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.231
ZD-78-BS65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299537
BRD-K04918285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83759
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MB-32-LQ97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246183
IE-19-LI00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235791
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.62474
BRD-K18031793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1861
CRCGN015_HEPG2_48H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00822
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.357303
CNKSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46014
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01225
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0546
BRD-K38190084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29202
CAL120_BREAST	CCLE Cell Line Proteomics	1.0	4.19101
SHISA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05278
Extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5558
FF-54-JC89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267618
BRD-K72098698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17418
GSE198036,GSE198041_0_v_2_sox9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291848
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59705
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
BRD-K61021741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91624
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24925
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.6866
BRD-K60952519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8725
BRD-K37515001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64036
Spiral organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.375
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.505205
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588758
FD-49-XC21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219328
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221511
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43238
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465049
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.985097
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204169
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283345
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06763
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54386
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251644
Mlxip	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27778
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.665139
GSE111247_2_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53923842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4401
Plastid outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.0
CRCGN016_MCF10A.TP53.M_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02327
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Copper ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.047
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CA-10-RU23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205738
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nem1-Spo7 phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
BRD-K34721572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32639
BRD-K78818514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26128
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IC-72-HR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268053
BRD-K41307047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32034
protein insertion into ER membrane	GO Biological Process Annotations 2025	1.0	null
Arntl	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.3307
GE-22-ME44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251281
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.618583
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Neuronal ceroid lipofuscinosis 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
BRD-K91654532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42742
BRD-K68162101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.413
RD_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	3.15772
BRD-K84551755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50892
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RORA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582703
Organelle subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.597
BRD-K61998715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25063
HOXC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03395
PMC12422825-aging-17-8-206293-s003.xlsx-i_MR_IP-Unnamed_5_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.027
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309052
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5572
BRD-K36382446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61904
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35777
BRD-K11757577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17683
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9851
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.533
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-05-KR03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287939
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.973
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65545
BRD-K48756106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36984
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09731
Leucoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.503
Katanin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0665
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PIGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555451
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14368
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20109
BRD-K09100418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61992
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2039
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.596268
Extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Sec61 translocon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.49
BRD-K56661847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84894
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AP5B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31372
10478_ZNF585A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.552465
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129292
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HB-72-BR75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226003
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.47622
arsenite transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54931539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31586
DD-71-LY65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380719
IC-08-NY46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240383
CPOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39403
BRD-K15426523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88907
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.48296
BRD-K92444813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04302
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51167279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07347
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04763
BRD-K62318087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23493
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35265
BRD-K93819193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31842
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.688545
AE-38-LX10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258171
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6115
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.591756
Miles-Carpenter syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
AA-62-HP31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295279
BRD-K59523233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26387
SNUPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584179
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-74-RX30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221603
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K75224334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17245
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4656
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09507
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.520013
GE-25-DQ65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210094
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533989
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9901
BRD-K25954314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29196
Middle silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14947
toxin-antitoxin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.895
BRD-K61087440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19397
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
Schizont	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.868
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528294
BRD-A63704386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9589
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
BRD-K14863829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08019
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90294313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47342
BRD-K20028052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18644
BRD-K27616003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9995
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10979
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331265
FD-81-SU40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318631
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloroplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.601
4921_MDN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548434
LPAR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491922
BRD-K05940224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9977
BRD-K16746805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03413
BRD-K01754882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16253
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.9788
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
RDH14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562221
External female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
BRD-K46298577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00988
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MSMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1594
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4362
CHD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00262875
BRD-K70717477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77613
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
Inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05516
MYLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587474
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226457
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09364
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137739
BRD-K15739647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19085
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465147
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13527
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.460689
BRD-K05135707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04635
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174312
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.38371
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.015
OA-15-DB28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226544
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00450629
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K81725246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23187
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RB-34-TO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414613
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-546-DOT1L_DOT1L	Rummagene Transcription Factor Associations 2026	1.0	null
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288857
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K70594121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22407
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63908919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56961
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.476
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95992
BRD-K70426100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33019
PMC5384880__F8	PFOCR Pathway Figure Associations 2023	1.0	null
Extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.633
PMC7614775-EMS178742-supplement-Proteomics_Table_1.pdf-213-ZNF276_ZNF276	Rummagene Transcription Factor Associations 2026	1.0	null
Extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zona pellucida receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.505
Chloroplast ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.977
NE-34-OZ69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309285
BF-02-AC35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234229
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339994
AB-39-ED84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21992
Pharyngeal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04488
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366516
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
EA-02-ZO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.519041
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236295
BRD-K98408574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15166
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.076
BRD-A46950333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04557
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.623838
BRD-K73995655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16063
HD-51-KD29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228095
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-12-IW93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2081
OV56_OVARY	CCLE Cell Line Proteomics	1.0	2.61292
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0608
BRD-K82765368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37398
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GA-04-JM33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394708
BRD-K02361314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61196
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25868
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607659
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.802
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.89804
BRD-K17020860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68114
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5137
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525918
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.562069
GATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22492
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388809
TNNC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598502
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.602
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38299
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.143
BRD-K65368843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03839
Autosomal recessive intellectual developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
Zellweger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.673
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23247
BRD-K38446773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10616
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4417
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143396
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4059
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A27056524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10425
Rough endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.296
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43812
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298928
BRD-K29143088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.433
BRD-K90444258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17312
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04535
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.385
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.574418
Larva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.57
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47984776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37555
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.928132
SHISAL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17002
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.4108
Actin cortical patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.696
BRD-K37625653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30378
BRD-K92433833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33247
Autosomal recessive nonsyndromic deafness 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5408
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP2_cds_exp_up-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24296
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03259
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11164
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.86231
BRD-K88447092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15023
snRNA-activating protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26082
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57541
GSE193993_1_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
585_GET3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.733135
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54958
FAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11007
BRD-K86914375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70231
Ghost	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.863
BRD-K16891407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25231
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30362
QA-34-PH05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403368
SRP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30575
Nuclear inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.533
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125478
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.8
BRD-K81181894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06196
BRD-K56783915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24951
Extrinsic component of intraperoxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.957
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.149
PAPSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00430293
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30511
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Strongyloidiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
AF-73-HJ84_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240588
HA-36-VD41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245976
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202893
CDC42SE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048138
BRD-K64717502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06492
p4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.32
ERGIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19788
Insulinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.573
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653455
BRD-K28017317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29039
ZC3H12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598231
CB-06-FE89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202028
CD-26-MB82_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38092
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00719
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.168
Protein aggregate center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-A07407288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86338
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1182
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.197
POFUT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721408
Chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.566
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237805
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19558
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30530468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84343
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32768
BRD-K24312231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54101
BRD-K07959057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25213
BRD-K79596575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12237
BRD-K57356416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47008
BRD-K16502264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0083
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
Carbon phosphorus lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-86-BE39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253464
CRCGN012_HEPG2_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13522
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476589
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.786653
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A96334094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91011
BRD-K14359942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04236
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.184
Etioplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169263_1_v_0_armc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spermatheca	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.258
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hep-G2/C3A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17979415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33637
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262507
BRD-A39031631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39822
KC-36-DK23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248009
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
protein insertion into membrane	GO Biological Process Annotations 2025	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_133_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98465548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20053
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22363
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225386
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.927305
GSE158100,GSE158101_1_v_0_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70315531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64497
GSE143994_0_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12739
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330534
Parkinson's disease 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
LE-55-RW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493866
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.667175
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388409
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.10264
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Peroxisomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A05823365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36587
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59877
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4115
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303045
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33606963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37684
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD248	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514793
BRD-K45112293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55875
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Reticulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.125
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00734874
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1358
BRD-K62497619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82664
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.02
ASTRA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
trans-Golgi network membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.917
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75079
CRCGN014_HEPG2_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13492
PAM complex, Tim23 associated import motor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
ZBTB48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10619
BRD-K94427708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04328
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.11
8820_TERF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517959
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
CRCGN013_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04771
GA-13-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203251
Cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
8167_SMG6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544946
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360474
Rough endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.068
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EE-01-FB85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270503
Plastid thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.015
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KD-68-JH25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372281
Craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
BRD-K60127720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43087
GSE112760,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JD-51-GD99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226167
BRD-K43381631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13317
CSTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88497
OC-21-IP52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286218
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167126
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.636346
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217677
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.282
Twist2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8526
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45941
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75038114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38263
ND-36-VC68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234165
BRD-K19378563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41607
BRD-K21546432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05834
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
TC71_BONE	CCLE Cell Line Proteomics	1.0	2.19674
BRD-K41829399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42346
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
Type IV secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
MCRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52296
SUDHL6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.29674
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.73058
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2489
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.68707
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6594
BB-27-MC77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254398
Periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.229
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347392
Divisome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.381
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.665123
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-41-IH69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214679
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05269173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75534
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-67-FF84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340067
Hypodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.318
Inner hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05816
BRD-K38984040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60681
BRD-K45642123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33178
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283157
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2215
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203396
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48505
NB-58-SA13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281184
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.7915
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242333_0_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9386
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1138
BRD-K77177732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2682
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5061
BRD-K60017729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15429
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20469
BRD-K12469242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57428
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79723
GSE141624_3_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.851827
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21177
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61755
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tail-anchored membrane protein insertion into ER membrane	GO Biological Process Annotations 2025	1.0	null
EMC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.981
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2666
BRD-K43284834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07786
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16803
NGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054766
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27723
BRD-K03476091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66428
Hrd1p ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.72301
FB-56-SR65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269512
BRD-K96379403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95758
Heart disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
CD-26-MB82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.7358
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314769
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-72-DZ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202716
SOX2-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
BRD-K91596921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96487
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290224
BAT3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.854
BRD-K28465224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0977
Progressive bulbar palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K93248080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00005
BRD-K32251128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2221
Hypodermal seam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.844401
BRD-K15930345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28321
BRD-K84235037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29709
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121457
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-54-JY76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236009
Autosomal dominant auditory neuropathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247459
Chloroplast thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.196
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20083
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.702
Nerve ring	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.009
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aspartylglucosaminuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-26-BO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220636
Nucleomorph	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.107
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Transcription factor TFIIE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.752
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.79851
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MPV17L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60451
BRD-K49443464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97378
Coelomic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.707
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.712
BRD-K37532736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39752
7751_SEC61A1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21941
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.791374
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209772
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32515
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3491
Congenital heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EIF3I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19707
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37780492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6872
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81324
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
BRD-K02337960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26618
MCF7_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117635
BRD-K30382953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01835
Dense core granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.053
BRD-K92524632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20669
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ND-54-FY31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262235
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81287
BRD-K59522787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22272
FD-72-CE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248762
Nicalin-NOMO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.517
SEC11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21656
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K52932858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68218
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66505
Plastid inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.942
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10746
BRD-K45315294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26768
SFT2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11852
BRD-K19965080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89054
PMC7518873-abb0205_Table_S1.xls-TFEB_targets-ensembl_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.734735
BRD-K79299080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0497
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489498
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76723780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12778
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267411
RHOQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07894
BRD-K35442564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8469
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.619506
BRD-K02050740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0044
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2622
BRD-A34826857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17789
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thylakoid lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.146
Infantile Refsum disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46445
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278992
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.772
BRD-K69375224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11614
UFD1-NPL4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
LK2_LUNG	CCLE Cell Line Proteomics	1.0	2.03728
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00758
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404159
HA-42-TE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303178
NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.19344
ABCB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10582
Ssh1 translocon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.515
CDH11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652595
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99807388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05172
BRD-K00744507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0783
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7892
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232008
FANCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00598
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42039
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.594
BRD-K25187028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8325
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ferredoxin-thioredoxin reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.505
MCF7_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164389
BRD-K61027868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18016
PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49721311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83187
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ML-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
Spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.302
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03809
Virion transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.843
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71015
DUS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01596
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7646
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HB-75-KT12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318618
A2780_OVARY	CCLE Cell Line Proteomics	1.0	2.07589
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5951
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-29-MQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2061
BRD-K04454173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45233
BRD-K04108962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18577
CD-13-QZ32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259772
Intrinsic component of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.569
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96968070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06393
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.623728
Glyoxysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.088
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00876
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29627
Thylakoid light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
BRD-K21753319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01788
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-01-DO31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246036
BRD-K91421454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15461
EE-99-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204542
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
PMC11443809-12967_2024_5663_MOESM3_ESM.pdf-114-CRX_CRX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65410345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25187
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31435
NR2F6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460651
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449196
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05964
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23074
Protein localization	Reactome Pathways 2024	1.0	null
QD-39-YV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219233
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450967
AB-71-VZ28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219184
Plastid thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.218
Gas vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
MCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54429
Signal recognition particle, endoplasmic reticulum targeting	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.032
CD-97-ZV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270568
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TRC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.47
BRD-K60662039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53372
AD-59-IN33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436188
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3803
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBA52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16686
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34135
PMC3697962__F2	PFOCR Pathway Figure Associations 2023	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.15666
ANO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00013
IL11RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547306
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FYTTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4451
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.473101
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Cpae	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.624
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Pulmonary emphysema	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
BRD-K39476596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59871
BRD-K92446632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06447
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.508593
UBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29869
BRD-K51320582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60608
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09015
BRD-K02393180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13276
DUOXA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606558
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4459
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THEM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05659
BRD-K15607890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03769
BRD-K27578003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58022
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_N1-GOPC_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.076
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77548697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95725
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Renal clear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04355
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
COBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592472
BRD-K37741838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32761
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85622
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225482
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6875
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.905
CD-26-MB82_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535082
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280987
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.671041
TCF12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573248
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Terminal loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Signal recognition particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.865
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.011
BRD-K55311609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90847
BRD-K88003497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00277
BRD-K46814258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75591
937_BUD13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05087
BRD-A04510218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93865
GSE209582_1_v_0_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MA-88-CA03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294055
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15797
CD-26-MB82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336375
Propionic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93601851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26982
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78438852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25236
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.520397
Cardiovascular system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478958
BRD-K25045770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01886
BRD-K25470159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05013
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186660_2_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58614056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2007
HC-11-RK51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.488787
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140221
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
DD-77-GV27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234302
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.801793
BRD-K64066545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48848
YA-21-RR66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212383
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.512406
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3443
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51765
BRD-K58044926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44762
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.315
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212458
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
KC-26-JQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23379
BE-25-UR78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369133
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276947
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-10-HD17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211962
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151119_3_v_1_hsf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151014
Posterior silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
Golgi trans cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.848
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Integral component of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.57
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.896
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.51735
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242179
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67256
BRD-K63568016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57077
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Peroxisomal biogenesis disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
BRD-K69408624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2891
GSE201042_6_v_10_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cochlear duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.364
1,3-beta-D-glucan synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39258
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.114
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12382
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
BRD-K22970494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89189
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13208
IC-80-CT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22785
GSE137653_2_v_3_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99000702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09175
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97678
BRD-K65005022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05907
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317409
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144936
BRD-K69528787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17259
Extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HC-18-NB46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238309
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323387
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
MF-81-RJ18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258232
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07174
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VNN3P	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580896
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0861
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11587
FAM221A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.666
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203997
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYBPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458619
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12823428-43587_2025_1018_MOESM3_ESM.xlsx-ST12-Supplementary_Table_12_Main_mendelian_randomisation_results_of_plasma_proteins_on_delirium_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
HDQP1_BREAST	CCLE Cell Line Proteomics	1.0	2.19071
BRD-K44984558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49264
BRD-K62213484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70806
IC-98-UO17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327365
BRD-A30369394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70993
BRD-K06439119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20568
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
EC-01-PH79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240353
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2082
BRD-K80803211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42637
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201529
BRD-K38854468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31444
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.808003
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8487
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4238
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09298
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3453
CRCGN009_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81685
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endoplasmic reticulum subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.631
BRD-K35469110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13602
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82638914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16559
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9629
BRD-K76755209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45415
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A69196860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16096
PMC12909836-44318_2025_675_MOESM6_ESM.xlsx-DA_E605_PerS1_M1_10_MQ-noMBR_MR-Unnamed_3_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79023
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.621
Cus cation efflux complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.047
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF763	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53145
protein insertion into membrane	GO Biological Process Annotations 2023	1.0	null
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBR7_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CD68	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553891
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.738566
FAM133B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20295
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
UC-80-UO92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241242
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.869002
CTR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8444
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393843
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70283
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9454
QE-18-WG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269315
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6308
ZNF800	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00123
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1177
SRPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00370822
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269927
GF-92-IR00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209108
BRD-K98841583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28432
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04706894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1856
Fatal familial insomnia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Ribbon synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.013
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A73618687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02103
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.714
Tic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.672338
BRD-K92344227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48302
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65574
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21643
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45288
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203609
Oligosaccharyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
BRD-K80196706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31097
BRD-K20051655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00812
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6119
DA-69-UN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36141
Macula lutea	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26693
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203598
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338472
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157049,GSE157051_7_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BC-09-JG96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38177
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09544
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76302
A549_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149795
BRD-K30594227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10162
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434252
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345948
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016701
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4737
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.526703
MX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10214
BRD-K00423214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04542
BRD-K52731958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62336
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14883
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.181
BRD-K78681155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31238
BRD-K75809222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0703
BRD-K25649596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48739
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237417
AB-25-XU75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239543
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29548
GSE181431_0_v_1_calr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08761
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PNMA6F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21367
BRD-K05409106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69506
PMC6263799__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337925
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2674
COL26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25419
PAT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.118
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11762
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50525
DNMT3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3446
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81199760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28823
HD-26-KX74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222609
Hedgehog signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.603
BRD-K69487032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08378
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
BRD-K73669270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18063
BE-38-UW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25977
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22552
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.805
GTEx Lung 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.52386
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38823
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01239
Chloroplast outer membrane translocon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.056
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3426
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6335096__F4	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K95171874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12954
GA-77-MH38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298929
BRD-K27248268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20784
KDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06807
GSE220520_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.231
PMC3430588-1477-3155-10-16-S1.pdf-33-CPEB1_CPEB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08867654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57657
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65181
BRD-K91796483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7377
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214964
AB-09-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291497
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
Toc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.542
PMC3348545-NIHMS263168-supplement-3.pdf-380-ZNF433_ZNF433	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74971765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0913
DB-21-FY25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210624
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
CA-10-RU23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231923
Membrane stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.255
Division septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.004
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A00680357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4099
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6581
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18912
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70625
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9117
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DE-30-UR76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326254
MIER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00777
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42333498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16184
BRD-K97962579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06015
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51281
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.028
CCSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32497
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.079
Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.35
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.8728
GAP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34079
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.21905
BRD-K36539857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89557
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215931
SSBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33035
Down syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209639
VB-92-JQ72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212743
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.508228
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22927
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14544
BRD-K46082763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55019
BRD-K95651150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32268
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291526
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48176
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20645
GSE189336_1_v_0_nitric oxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MN-9D cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439713
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K86774687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49187
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46393
Perinuclear endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.376
BRD-K73841784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03274
BRD-K67591072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57992
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
GSE112860_5_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02406
CRCGN016_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01381
USP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23122
ARIH2OS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564223
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8682
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3276
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
Emery-Dreifuss muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.859
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3163
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0511
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.784676
BRD-K64770897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09683
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06781
Nestor-Guillermo progeria syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
XA-12-UL84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482208
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240719
PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37021
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7833
AC-95-NR38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206198
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283671
Leaf epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
IL18BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528465
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04641
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187019
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51737
PMC12529848-12967_2025_7217_MOESM3_ESM.xlsx-Table_S4-Table_S4_Associations_of_genetically_proxied_proteins_with_risk_of_atrial_fibrillation_by_MR-SPI_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83270266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20225
BRD-K86019347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31658
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.058
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.006
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13655
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MHC class I peptide loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.889
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.818
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81971
Endoplasmic reticulum chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.35
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:E02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17335
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26756
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02999
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214777
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLYATL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629423
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42459
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3266
STAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00456181
BRD-K57315740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13593
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203353
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.883876
EA-40-KQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240059
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477504
BRD-K77150932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77312
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11038
Pyrenoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.607
BRD-K95428783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16264
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273353
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4765
MDAMB436_BREAST	CCLE Cell Line Proteomics	1.0	2.03188
ED-32-VE54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.696718
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309559
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34856
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4084
MCF7_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169043
LIVF001-018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12705
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5777
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30643363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2922
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391613
BRD-K78697404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25814
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254927
BRD-K83527041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03652
Microbody lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.624
BRD-K71247208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52352
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.427232
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSI associated light-harvesting complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.897
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.512
BRD-K93457574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12347
OB-15-UL37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243305
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
Nuclear membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.399
Microbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.875
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.75966
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	65.3983
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24684
FLYWCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37186
BF-03-RM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231741
CEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6056
BRD-K53748177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2002
GD-71-OU80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435711
GSE110708_1_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABRR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00375828
A673_BONE	CCLE Cell Line Proteomics	1.0	2.5134
VD-41-XP62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413448
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42663584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26914
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.789355
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.392
BRD-K17514980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38134
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06964
Chlorenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366021
GSE111247_2_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nuclear MIS12/MIND complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.245
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
TOV-21G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
Anterior silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00718373
BRD-K33287655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09865
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
ZNF30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42077
BRD-K37000177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67978
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.644088
BRD-K38424085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06576
Signal peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.37
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.39986
Nitrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.565
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323848
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50194
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49223
BRD-K34624391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67239
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rhizomelic chondrodysplasia punctata	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
Peroxisomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.627
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5053
GSE182680,GSE182683_10_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CXCL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631018
BRD-K89632963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89882
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.812342
SNU1079_BILIARY_TRACT	CCLE Cell Line Proteomics	1.0	4.29276
BRD-K04508260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29423
Leaflet of membrane bilayer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.646
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-78-TY66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232177
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.371253
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.694
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3169
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135894
KC-32-GO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282302
B4GALT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14409
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327064
akr2b	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53443314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08047
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25425
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20189
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.64948
BRD-K76734722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51863
BB-21-XL84_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213347
BRD-K01417352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00913
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91897530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78462
NCIH520_LUNG	CCLE Cell Line Proteomics	1.0	2.23405
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82105033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09974
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
protein insertion into ER membrane	GO Biological Process Annotations 2023	1.0	null
TSC22D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01325
BRD-K21786986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.622
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47283018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34973
HC-18-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250108
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.533127
BRD-K63189715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22722
UQCRC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718126
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GABRA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00311542
Rough endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.119
BRD-K77697725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16613
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
CUL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00257
Lsd1/2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
MCF7_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119233
PMC3792350__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
Breast adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.464
Polycystic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
BRD-K76449854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04511
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40362
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93659
BRD-K36134264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49226
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.469827
RPP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11906
BRD-K33891642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02638
BRD-K75330923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11652
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10216
FA-92-JL46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205358
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50925
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450246
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15105
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Cone cell pedicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6728
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.749089
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38248
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03442
BRD-K89952634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09963
MF-20-QI53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351968
BRD-K65959331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05592
Chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.53
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237574
BRD-K98695520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03307
BRD-K48900723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23914
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.558481
GET complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K85294251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4972
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34805
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.144
BRD-K29253960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12342
BRD-K29571884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19664
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232617
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261103
BRD-K50053371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24058
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207924
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0936
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342992
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-84-KP45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214171
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240025
GD-59-OG21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217594
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04754
MIAPACA2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.04779
BRD-K97486995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09308
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.125
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.61463
BRD-K89366873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61443
REPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495419
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1855
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244126
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25581
BRD-K26680822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62064
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56865
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.631
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391906
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-encode-consensu_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.603837
DE-20-VX20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435249
GE-22-ME44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216461
Endoplasmic reticulum exit site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
RPS6KA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00483232
IFIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31526
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1379
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S23_LF_C1_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
HE-22-JR80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432089
Kohlschutter-Tonz syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hyperphosphatasia with impaired intellectual development syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
BRD-K72833997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79545
Pancreatic agenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35131
RZZ complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
BRD-K88282877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31903
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274363
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-08-SZ54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210434
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2049
BRD-A98795688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10044
BRD-K29320859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30606
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.718277
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0759
RNASEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52052
BRD-K09146396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96119
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180939
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04665
BRD-K66016089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2457
GSE112762,GSE112767_1_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HF-67-IR57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238808
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452524
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6897
B3GNT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50149
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96845170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11502
BRD-K89436979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16148
GTF2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28381
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508961
AA-56-QO38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204895
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-62-XS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388318
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41639
GSE113267_0_v_1_rfx7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471362
PTK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00324372
AF-80-GK24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260543
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SYP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01046
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521303
PD-60-FM93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33175
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293268
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54092
BRD-K12239796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28146
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
Mitochondrial intermembrane space protein transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3928
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62545
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248886
BRD-K69154646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30085
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51682
SB-94-ZA83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254186
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARVCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96969
GSE176008_4_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
DMRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87931
Endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.497
XC-13-LW13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291946
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.18824
BRD-K69441986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61878
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3629
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49544
BRD-K16207499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32025
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-38-WM38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267367
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235902
Endoplasmic reticulum quality control compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
BRD-K17570530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19302
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315035
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51563
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465243
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DC-17-ZB19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215467
Vacuolar transporter chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97407
BRD-A71722688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2102
nucleolus	GO Cellular Component Annotations 2023	1.0	null
BD-90-DK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223138
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44753
BRD-K74892102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3053
PMC7110753__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K76400756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33131
BRD-K16681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04276
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14086
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Phosphatidylinositol 3-kinase complex, class III, type II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.307
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259461
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
GB-96-WX99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290085
Chloroplast thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0801
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-16-BE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292529
CC-84-JQ48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212262
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54246
BRD-K37684893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06109
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54837058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0625
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83690550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65327
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267423
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238743
MYRFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17928
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71839680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03164
cinchophen	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25174
BRD-K49656278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67187
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.5589
Modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
BRD-K73830970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4448
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7553775-elife-61287-supp1.xlsx-Muller_2014_DREAM_bound_genes-Genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48133
BRD-K15627143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10169
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75386
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5255
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21873
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-29-VD14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208246
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28067
Sec62/Sec63 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.315
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNAI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681838
Gravid adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.529135
Amyotrophic lateral sclerosis type 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16835
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
Peroxisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.876
BRD-K65086352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36175
GM1 gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013075
Arnt::Hif1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7019
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9555
PKN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00392214
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.37834
BRD-K10181552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38877
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63745
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Silver ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.047
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.461435
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A96183603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24958
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEx Lung 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-10.1673
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Exocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0193
CAV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592322
BRD-K34343777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37946
BRD-K98537764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14071
SRSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02991
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prefoldin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
CRCGN008_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1542
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79174
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.46619
BRD-K07624584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24861
BRD-K04488512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06294
BRD-K44696459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04271
BRD-K82700281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16699
BRD-K62909976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07493
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14636
Chloroplast inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.942
GBP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066259
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.648928
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.0154
CRCGN013_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07495
BRD-K11571815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12427
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36737730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01863
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45565
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5537
BRD-K96652989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18678
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-826-ENSG00000197044_ZNF441	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97223487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78633
AA-67-TF79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234018
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26399271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0033
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
585_GET3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.600944
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2594
Chromosomal duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6696
Nuclear pore linkers	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.775
AE-06-FY47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396015
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99674
HD-26-KX74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391466
inorganic anion transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33102216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06714
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UNC93B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68687
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173247
BRD-K85362541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83255
Hypomyelinating leukodystrophy 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
Mouth	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K65184008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12446
Extrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.67
RMDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21076
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-377-ZNF441_ZNF441	Rummagene Transcription Factor Associations 2026	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322138
BRD-K84348716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00558
BRD-K23825243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37529
Endoplasmic reticulum Sec complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.312
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59965
BRD-K80424876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0045
BRD-K97537859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27673
BRD-K07530355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11458
Cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
IL1RAPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00823409
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4245
ANPR-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
ZBTB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71679
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9771
BRD-K47164766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14258
BRD-K44956383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58611
BRD-K36909552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30011
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.843542
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K82249895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00267
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
BRD-K04275703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13711
BRD-K08233096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09815
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EC-01-PH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218327
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13393
BE-66-UB12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261664
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.55095
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38895
BRD-K43535770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74073
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67905
MICAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52422
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9443
MutS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414426
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Synaptic ribbon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.09
BRD-K16167206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59747
Rostral migratory stream	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.654
Metallochaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239436,GSE239441_0_v_1_keap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LM3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
HESX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00423872
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259418
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29905
PMC12271601-mmc2.xlsx-OUT_cells_01-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339588
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07847
BRD-M39894156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18238
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07495
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.5288
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Reactome Pathways 2024	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_3_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9349
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MD-92-KD16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273238
ALG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30172
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16315
PMC12079334-ADVS-12-2501734-s002.pdf-188-ENSG00000188868_ZNF563	Rummagene Transcription Factor Associations 2026	1.0	null
AB-09-EA37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465264
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06523
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74870161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15091
BRD-A60076435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.193
SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.571
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09734
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27905
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67048
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.957396
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378391
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00001
Chloroplast outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.006
protein localization to organelle	GO Biological Process Annotations 2023	1.0	null
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153204
BRD-K37283718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19478
BRD-K28932860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51218
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
IF-03-OL58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202543
BRD-K56650430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83589
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353711
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.577069
SMYD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00445811
BRD-K44483161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22184
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.035
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.606947
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.724108
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.177
BRD-K83049611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64708
BRD-K04317371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85208
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07954
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5648
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46947
RD-50-EO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244202
BRD-K40826084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24018
XC-13-LW13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20488
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236163
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55669
CRCGN014_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52735
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56971
BRD-K34414758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16366
ITK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00498348
EPHB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455692
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351805
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0559
BRD-K59324446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24986
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Congenital disorder of glycosylation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
PMC10913870-pr3c00632_si_001.pdf-84-ZC3H8_ZC3H8	Rummagene Transcription Factor Associations 2026	1.0	null
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202813
TAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.381
NoRC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.734
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209906
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51001
TBY-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
Chloroplast thylakoid membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
Cardiomyopathy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112760,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-72-QI84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218952
PSII associated light-harvesting complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.614
GSE184087_0_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-11-RK51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579134
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38905
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11712
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Curli secretion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111052
BRD-K84514454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12526
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9973
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4974
Cerebellar atrophy, visual impairment, and psychomotor retardation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	2.16078
1395_CDC26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580043
KMT5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047099
RSBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433454
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228946
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4814
IFT20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29956
embryonic lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1617
DD-30-SX80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226524
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Symbol_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212373
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15936
PJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15915
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.4
BRD-K90429860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.032
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222958
MNDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08121
SOX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50743
BRD-K14375485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34961
Myotonia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18651
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155357
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0986
Chlorosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.208
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14477
ATP5ME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29513
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445255
GET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.638
BRD-K24385654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59003
Chloroplast intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.505
PMC6683136-41598_2019_47363_MOESM3_ESM.xlsx-GENE_SET-Negative_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
protein targeting to membrane	GO Biological Process Annotations 2023	1.0	null
CRCGN010_HEPG2_24H:H17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51542
BRD-K30799912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31934
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.668
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.62837
BRD-K90163297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31141
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215137
AB-30-DA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454359
BRD-K74129999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65417
b192	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.133
AGTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491226
BRD-K13619800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15237
BRD-K81124412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65036
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3176
DC-84-CJ21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327617
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4747
Coelomocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.728
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10043
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46979
AGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24717
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12460934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47287
Female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
PYGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48182
ER membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.798
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.842665
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Condensed chromosome, centromeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.384
BRD-K84541452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32087
BRD-K07762528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69778
BRD-K08389897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11751
BRD-K83898111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83531
PC-80-LV29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313791
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271596
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TNPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04907
Aggresome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81217407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09745
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08903
BRD-K16670438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08336
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PTGER3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512302
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17601
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
BRD-K49094605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29804
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.638858
BRD-K21771449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03266
S0-EE-XMXE_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200286
Glycosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.965
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57734337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30398
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6176
BRD-K03057797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4269
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33614
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235418
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BF-89-QD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228551
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1708
RNH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06823
BRD-K58876832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61065
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.30877
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3724
BRD-K70945620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15736
AB-31-VZ28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234565
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05531
NYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01255
post-translational protein targeting to endoplasmic reticulum membrane	GO Biological Process Annotations 2023	1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236163
BRD-K95729740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2554
EB-67-WB79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204055
PHARC syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
FOXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13044
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
CF-97-KZ12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388679
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OV-7	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
endoplasmic reticulum organization	GO Biological Process Annotations 2025	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365347
WF-85-JN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365859
Chromoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75073374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63267
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
MA-88-CA03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385525
BE-59-WG31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285626
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.276
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31969
BRD-K68665079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54653
BRD-K04611090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15499
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5243
VIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31128
BRD-K37398853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45285
tail-anchored membrane protein insertion into ER membrane	GO Biological Process Annotations 2023	1.0	null
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145566
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
endoplasmic reticulum organization	GO Biological Process Annotations 2023	1.0	null
BRD-K18600476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2461
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95941
BE-03-XC62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299557
CTAGE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9923
protein localization to organelle	GO Biological Process Annotations 2025	1.0	null
Plant parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32758
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3786
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149473
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381092
BRD-A59391763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02084
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247409
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Ensembl_ID_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12105
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4382
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16695
BRD-K43503317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33563
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.016
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_85_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15474464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08986
arsenite transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN014_HEPG2_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86536
Buruli ulcer disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
CCNF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27828
11294_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582205
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CISD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19949
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.044
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5164
CGGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20929
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.928
BC-20-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377155
GTPBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30656
XAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6068
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8018
DF-70-CD57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20264
NPC1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534763
BRD-K15393664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15998
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MIS12/MIND type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.908
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72022
COL8A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534717
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34531548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69401
BRD-K10460649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89358
BRD-K36104357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1451
Macrophage_Spleen_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138235
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-28-MC54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25569
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635092
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
LRRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18134
Body wall muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
AFF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490821
AA-67-TF79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284922
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5543
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
Organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.358
Cytosolic proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.15
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43224
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4271
BRD-A81260764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33282
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26915
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00809