association	dataset	threshold value	standardized value
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835195
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal astrocyte morphology	MPO Gene-Phenotype Associations	1.0	null
leads	GeneRIF Biological Term Annotations	1.0	null
BRD-K33775409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30743
Spastic Gait	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36804
CAPN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16955
individuals	GeneRIF Biological Term Annotations	1.0	null
PDZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76407
gap junction	GO Cellular Component Annotations 2023	1.0	null
BRD-K43495666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12424
ACCMESO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77112
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12753
Lymphatic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.82
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91542
homozygous	GeneRIF Biological Term Annotations	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.39872
Rotavirus infection of children_Peripheral blood mononuclear cell_GSE2729	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.55285
RESF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33765
abnormal appendicular skeleton morphology	HPO Gene-Disease Associations	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043336
SOX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63008
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02961
Fetal Heart	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.933827
LAT	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN012_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28978
fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.517284
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07878
CSPG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05001
EIF3J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7752
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52181
Hypotrichosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
abnormality of the lower limb	HPO Gene-Disease Associations	1.0	null
GTEX-UPK5-2126-SM-4JBJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00406
CCNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51545
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SALE	CCLE Cell Line Gene Expression Profiles	1.0	1.81907
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824057
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Internode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.874
DU4475	CCLE Cell Line Gene CNV Profiles	1.0	1.77849
Charcot-Marie-Tooth disease X-linked dominant 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.769
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76679
SAFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12149
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Corpus callosum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Strabismus	DisGeNET Gene-Disease Associations	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.06691
RERF-LC-FM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
aplasia/hypoplasia involving the central nervous system	HPO Gene-Disease Associations	1.0	null
FOXN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88783
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.11275
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44445
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Recurrent Skin Infections	DisGeNET Gene-Phenotype Associations	1.0	null
HSD17B10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86083
Hypomyelinating leukodystrophy 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.933
A172	GDSC Cell Line Gene Expression Profiles	1.0	1.81954
Gap junction protein, cysteine-rich domain	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8317
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
P31-FUJ	GDSC Cell Line Gene Expression Profiles	-1.0	-2.46001
GTEX-Q2AH-0426-SM-2I3EP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918151
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840082
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03266
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11572
SYNCRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65202
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93812
PRKCA_knockdown_118_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.6585
TGIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28901
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4637
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53326
CHPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70207
RBM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54489
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06343
TCF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81716
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.869353
abnormality of central motor function	HPO Gene-Disease Associations	1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949576
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.110952
BRD-K95410891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37197
Difficulty Walking	DisGeNET Gene-Phenotype Associations	1.0	null
Cellulitis	DisGeNET Gene-Phenotype Associations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain myelin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.655
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47065
NDST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05848
Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05224
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95285
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11089
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
abnormal hematopoiesis	MPO Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
corpus callosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.936199
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FBXO44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30117
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07549
BRD-K77139764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10277
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03162
MRPS18B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28162
Scoliosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
Sympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.872
DNASE1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70781
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927655
GSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95975
BRD-K48880196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03923
abnormality of the cerebral subcortex	HPO Gene-Disease Associations	1.0	null
BRD-K26904107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03948
HK2	CCLE Cell Line Gene Expression Profiles	1.0	1.60985
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.9844
GSE124471,GSE124488_1_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Stalk cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
SF3A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00917
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29525414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26452
ETAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51151
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.4814
YES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1592
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884713
CEBPB	ENCODE Transcription Factor Targets	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
UBAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89016
Yellow nail syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
screening	GeneRIF Biological Term Annotations	1.0	null
NFE2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44222
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956213
ZBTB42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23663
FKBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08249
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K36me3_splenic B cell_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.5505
GTEX-XUZC-0326-SM-4BOO8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909847
Neuronal cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.347
Troyer syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
TUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56784
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22926
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
linkage	GeneRIF Biological Term Annotations	1.0	null
cerebral gray matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.506672
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04163
FAM118B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32706
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.63038
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6148
GTEX-XYKS-1026-SM-4BRVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25638
TIA1_KO_GSE54418_267_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.838637
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4428	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34813
QTRTD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828718
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.14697
central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913243
forms	GeneRIF Biological Term Annotations	1.0	null
TIG3TD	CCLE Cell Line Gene Expression Profiles	1.0	1.48157
RAD23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77434
BEND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4728
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18619
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59096
localized	GeneRIF Biological Term Annotations	1.0	null
SNU324	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50087
response to toxic substance	GO Biological Process Annotations 2015	1.0	null
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
global developmental delay	HPO Gene-Disease Associations	1.0	null
Slowed Saccades	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Gap junction trafficking	Reactome Pathways 2024	1.0	null
myopia	HPO Gene-Disease Associations	1.0	null
NR3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65213
earlier	GeneRIF Biological Term Annotations	1.0	null
abnormal glial cell morphology	MPO Gene-Phenotype Associations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11987248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29713
BmN4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF316	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23651
urinary incontinence	HPO Gene-Disease Associations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.841822
BT483	CCLE Cell Line Gene CNV Profiles	1.0	1.35931
Chronic Acquired Lymphedema	DisGeNET Gene-Disease Associations	1.0	null
disorder	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06761
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08583
Palmoplantar keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
PANK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99661
cognitive impairment	HPO Gene-Disease Associations	1.0	null
Pathologic nystagmus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
KDM7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34307
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35151
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.850849
FXYD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90273
COLO704	CCLE Cell Line Gene CNV Profiles	1.0	1.3662
symptoms	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953125
BRD-K24070365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39801
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.10229
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Neuron projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.498
RYR2	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86367
GTEX-POMQ-1226-SM-3P61F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01174
OLIG2-29049317-MOUSE-SPINALCORD	ChEA Transcription Factor Targets 2022	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72315
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29496
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19828
SW900	COSMIC Cell Line Gene Mutation Profiles	1.0	null
extending	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98474
SAMD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19323
choreoathetosis	HPO Gene-Disease Associations	1.0	null
IGDCC4	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal eye morphology	HPO Gene-Disease Associations	1.0	null
BRD-K95761590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03059
ERI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.61342
vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50128
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6137
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31823
Mitochondrial respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
abnormal cerebellar purkinje cell layer	MPO Gene-Phenotype Associations	1.0	null
FERMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45007
hematopoietic system phenotype	MPO Gene-Phenotype Associations	1.0	null
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02061
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15362
duodenum	HPA Tissue Gene Expression Profiles	-1.0	-1.08757
carried	GeneRIF Biological Term Annotations	1.0	null
Upper Limb Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
parents	GeneRIF Biological Term Annotations	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.935826
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rearrangements	GeneRIF Biological Term Annotations	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924566
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57266
MM253	DepMap CRISPR Gene Dependency	1.0	2.50498
CNNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19852
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.06162
CPOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92287
BRD-K07740919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9663
RNFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1135
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946094
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
NEU	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
TBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95161
BRD-K03383196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25953
BRD-K26127374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91216
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19538
BRD-K39192716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28163
abnormal professional antigen presenting cell morphology	MPO Gene-Phenotype Associations	1.0	null
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7815
PMC11031166-SAG-2302-87_0_Appendix_1_SG_IHDS_(569_genes)_Final_List.xlsx-AP1-Genes_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
OPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53061
slow saccadic eye movements	HPO Gene-Disease Associations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.844904
GSE201217_2_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93819193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16856
Other Sphingolipidosis	DisGeNET Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2655-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.829
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73322
RNF149	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5899
BRD-K25387295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48249
WASHC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53296
U343	CCLE Cell Line Gene Expression Profiles	1.0	2.12187
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869806
clinical modifier	HPO Gene-Disease Associations	1.0	null
PACSIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15032
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.293866
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05658
exclusive	GeneRIF Biological Term Annotations	1.0	null
related	GeneRIF Biological Term Annotations	1.0	null
MISP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79202
BRD-K78082598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31821
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87131514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02758
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.838412
congenital nystagmus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.937459
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.567626
BRD-K16064200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1492
CARNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70561
Hypokinesia	CTD Gene-Disease Associations	1.0	1.05936
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.765
Mural cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
PRKCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73376
TLN2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056261
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Peroxisomal biogenesis disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
NFYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00931
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18508
ZNF367	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55612
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0031
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.203
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47535
TSHZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32677
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73919
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
leukodystrophy, hypomyelinating, 2	OMIM Gene-Disease Associations	1.0	null
DNAJC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55534
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837021
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-0626-SM-3P61E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886873
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
ASB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43285
founder	GeneRIF Biological Term Annotations	1.0	null
PINX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46738
molecular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.710909
NPIPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68293
Peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.882
BRD-K71015709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56516
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49435
PLAG1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SN-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.8231
Testicular Hydrocele	DisGeNET Gene-Disease Associations	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91224
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14095
PRMT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01492
neurological speech impairment	HPO Gene-Disease Associations	1.0	null
cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118743
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Krabbe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.846
SSH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39988
SPATA31A7	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12717993-MEC-34-e17796-s002.xlsx-ST12_WGS_RFMix_genes_2_anc-Unnamed_14_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal immune system morphology	MPO Gene-Phenotype Associations	1.0	null
abnormality of peripheral nerve conduction	HPO Gene-Disease Associations	1.0	null
BRD-K10911459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2492
Autosomal recessive disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
vestibular labyrinth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305001
USP46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67445
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.833288
severe	GeneRIF Biological Term Annotations	1.0	null
Renal pyramid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.777
cause	GeneRIF Biological Term Annotations	1.0	null
neurodevelopmental delay	HPO Gene-Disease Associations	1.0	null
Neuromyelitis optica	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.945
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03959
hsa-miR-125a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Saos-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5084
RLF	Pathway Commons Protein-Protein Interactions	1.0	null
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071511
hereditary lymphedema	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.446182
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7348
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1773
BRD-K08442552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2975
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.34898
Hypomyelinating leukodystrophy 19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.751
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.961768
Lung squamous cell carcinoma_LUSC_TCGA-58-8390-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932187
BRD-K64593260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22063
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.888945
Leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.01
PMC11511846-42003_2024_7078_MOESM3_ESM.xlsx-ST18-Unnamed_19_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16465
BRD-K61924932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23563
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6486
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25138
GTEX-XMK1-1826-SM-4B66F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25201
abnormal astrocyte number	MPO Gene-Phenotype Associations	1.0	null
BRD-K77663497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35739
Spastic Paraplegia 44, Autosomal Recessive	CTD Gene-Disease Associations	1.0	2.88009
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2194
BRD-K09777330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23857
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM59L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54809
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58045
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46213
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40768
Hereditary lymphedema II	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.21
Gican	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
CRB1	Pathway Commons Protein-Protein Interactions	1.0	null
dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.196459
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27073
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7890-01A-12R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27353
GLCCI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58724
rigidity	HPO Gene-Disease Associations	1.0	null
SLC4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46531
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30989
STAT3	ChEA Transcription Factor Targets	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67689
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.985393
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AKT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86097
SERPINE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35476
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.995874
PMC12534504-41598_2025_20489_MOESM1_ESM.pdf-314-FOXP4_FOXP4	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07007
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864527
muscular hypotonia	HPO Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
NEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.52002
BRD-K90863245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31895
ELF1	ENCODE Transcription Factor Targets	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.708
myelin sheath	GO Cellular Component Annotations 2015	1.0	null
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83278
BRD-K95334975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90958
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77689
BRD-K48332223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17602
Hemangiosarcoma	DisGeNET Gene-Disease Associations	1.0	null
ZNF91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47728
ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.309697
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0609
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1866
RAB22A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07979
BCLAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91938
Hereditary spastic paraplegia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.71
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08887
forming	GeneRIF Biological Term Annotations	1.0	null
BRD-K92967681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73938
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.837584
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4731
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19634
ZDHHC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9615
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.950493
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088292
GTEX-WEY5-0726-SM-4LMID	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952317
FOXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40446
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.964991
outer SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04085
FBXL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96241
GTEX-QXCU-0126-SM-2TC5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08188
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073925
Dysmorphic Facies	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K31602464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21982
SNURF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89246
cerebral white matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.17269
SCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6773
Autoimmune disease of peripheral nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.844
nine	GeneRIF Biological Term Annotations	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
constipation	HPO Gene-Disease Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDX43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89325
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
etoposide_mus musculus_gpl6887_gse33626	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Traumatic brain injury	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13845
SP2_02_42	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60659
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.823
TSPAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00599
Glial filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.14291
ZKSCAN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55312
BRD-K08881846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04457
ACSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75336
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59639
astrocytosis	MPO Gene-Phenotype Associations	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Small saphenous vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
BRD-K33865795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.91322
PALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56303
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00444
Cns Hypomyelination	DisGeNET Gene-Phenotype Associations	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
SLA2	Pathway Commons Protein-Protein Interactions	1.0	null
Klippel-Trenaunay syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
ventrolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992672
F8A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52433
Hypomyelinating leukodystrophy 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.43
dinoprost-3308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.27636
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865667
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KCTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69071
DUS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52379
Vohwinkel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
Hereditary spastic paraplegia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.897
BRD-K38692266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18289
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15929
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11429
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45684
GTEX-TMMY-2226-SM-4DXTN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16532
TIFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24654
Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Charcot-Marie-Tooth disease type 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
Sjogren-Larsson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
BRD-K39179354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05359
Glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.503
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35214
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040397
F12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67726
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38695
Congenital Epicanthus	DisGeNET Gene-Disease Associations	1.0	null
PACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46663
PPP1R16B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00698
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12957
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46824282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06312
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850197
abnormality of the inner ear	HPO Gene-Disease Associations	1.0	null
BRD-K77638937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47829
LYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29617
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
CROT	Pathway Commons Protein-Protein Interactions	1.0	null
U87MG	DepMap CRISPR Gene Dependency	1.0	2.03398
FAM78A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6839
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34111
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50285
Multiple mitochondrial dysfunctions syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
VSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32345
BRD-K36208388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19272
PCDH1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855604
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK2	KEA Substrates of Kinases	1.0	null
GTEX-RTLS-1226-SM-46MUP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840337
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07549
PLEKHA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23718
EPS15L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85218
MDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24321
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.29998
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934512
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40562
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12779
autosomal	GeneRIF Biological Term Annotations	1.0	null
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.63443
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18858
AP5B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32535
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
lymphatic endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.56603
retains	GeneRIF Biological Term Annotations	1.0	null
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.953317
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	149.079
H3K36me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
Lung-capillary aerocyte	Tabula Sapiens Gene-Cell Associations	1.0	0.345425
EWS502	CCLE Cell Line Gene Expression Profiles	1.0	1.38581
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
abnormal locomotor activation	MPO Gene-Phenotype Associations	1.0	null
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4037
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
RING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61569
hearing abnormality	HPO Gene-Disease Associations	1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.1688
CPNE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23432
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Membrane Trafficking	Reactome Pathways 2024	1.0	null
Poor Speech	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K80622681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57228
Hereditary spastic paraplegia 50	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
ISG15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9801
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65734
Primary progressive multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38987
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29787
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4784-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u937	HPA Cell Line Gene Expression Profiles	-1.0	-0.886243
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_8_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
HCC364	CCLE Cell Line Gene Expression Profiles	1.0	1.45889
Prostate-basal cell of prostate epithelium	Tabula Sapiens Gene-Cell Associations	1.0	5.70559
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9559
FOXI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52635
NFKBIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28047
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872898
TAF7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellulitis	HPO Gene-Disease Associations	1.0	null
BRD-K39709957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34731
MT-ND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80248
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11504
Neurofilament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.526
hsa-miR-4267	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882241
PHOSPHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9306
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50098
ITPRID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15805
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
BRD-K51270604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79115
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14503
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65152352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66312
cognition	GeneRIF Biological Term Annotations	1.0	null
BRD-K82362034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40166
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K64299311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31921
SLC17A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62008
Syntrophin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.6068
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855301
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
Bart-Pumphrey syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
BRD-K03089783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23237
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
B4GALT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60826
RASA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33124
DVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13396
abnormal cns glial cell morphology	MPO Gene-Phenotype Associations	1.0	null
milder	GeneRIF Biological Term Annotations	1.0	null
Paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Leukodystrophy, hypomyelinating, 2	ClinVar Gene-Phenotype Associations	1.0	null
Breast Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42934
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4729
abnormality of facial musculature	HPO Gene-Disease Associations	1.0	null
BRD-K16554464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09797
Aicardi-Goutieres syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.7453
CRCGN014_HEPG2_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09885
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.55328
Venule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.176
JHOM2B	CCLE Cell Line Gene CNV Profiles	-1.0	-2.50488
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03128
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.950493
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.00417
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10317
JURKAT	BioGPS Cell Line Gene Expression Profiles	1.0	1.31121
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28844
RANBP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37803976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3155
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052752
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857593
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055711
Hypomyelinating leukodystrophy 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.39
PMC12354852-41467_2025_62818_MOESM3_ESM.xlsx-Sup_Data_10-Differentially_expressed_genes_in_TAF6L_KD_vs_Control_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SACS	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18213
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.601
Apical junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.266
MRPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40652
no abnormal phenotype detected	MGI Mouse Phenotype Associations 2023	1.0	null
ZNF780A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01381
MATCAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5208
BRD-K54549319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.99359
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31738
titubation	HPO Gene-Disease Associations	1.0	null
Perturb_13852_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Neuron projection cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.305
BRD-K15863674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76037
MLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53728
Pia mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
P30-OHK	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64353
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041428
DGKG	Pathway Commons Protein-Protein Interactions	1.0	null
INSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30059
ZR7530	CCLE Cell Line Gene CNV Profiles	1.0	1.4801
CNOT1	Pathway Commons Protein-Protein Interactions	1.0	null
AGO2_02_132	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.64386
Edema	CTD Gene-Disease Associations	1.0	1.19966
oligodendrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.74027
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.8604
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.925395
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.25207
GTEX-U412-0826-SM-3DB9K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903302
BRD-K58757743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25952
BRD-K73562260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35615
RANBP3	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.937112
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60106
HOXA5_01_305	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.00523
ZNF429	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04931
Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.067
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03358
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	1.0	null
C6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
within	GeneRIF Biological Term Annotations	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08048
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
Paranodal junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.56
HS729	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54948
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21062
hsa-miR-4680-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922882
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90408
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6201
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06847
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal microglial cell morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K10276373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26179
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
PATU8988T	DepMap CRISPR Gene Dependency	1.0	5.2582
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8221
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63275
H3K36me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
Connexin complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.5226
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K26704304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32076
NCI-N87	GDSC Cell Line Gene Expression Profiles	1.0	1.53098
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1259
APOE	Pathway Commons Protein-Protein Interactions	1.0	null
AP1M1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40683
LN319	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4081
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44883
SKRC20	CCLE Cell Line Gene Expression Profiles	1.0	1.4706
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.298
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-50-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39326623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41744
TBC1D16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32665
PITX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66928
CXXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19571
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00494
HSOS1	DepMap CRISPR Gene Dependency	1.0	3.01129
Perturb_4236_KD_Cnot7_SRP091584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.86167
GABBR1	Pathway Commons Protein-Protein Interactions	1.0	null
Hereditary spastic paraplegia 61	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82427
GTEX-T5JC-1826-SM-4DM6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943558
BRD-K64698045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05472
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Vein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36462
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2208
ZNF652	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6609
Oligospermia	CTD Gene-Disease Associations	1.0	1.17993
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956706
MGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80514
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116242_0_v_1_olig2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pleated septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.067
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19419
CFLAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26602
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049704
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NOTCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.191
AZIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0888
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.961217
KLF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10532
equal	GeneRIF Biological Term Annotations	1.0	null
Pituicyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92884
GTEX-VUSG-1126-SM-4KKZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846182
abnormal voluntary movement	MPO Gene-Phenotype Associations	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.94612
SNU324	CCLE Cell Line Gene CNV Profiles	1.0	1.41159
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8095
FOXP1	ChEA Transcription Factor Targets	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Connexin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.871
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348148
NPAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45693
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07839
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87712055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71305
NCIH1105	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83341
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13987
spastic paraparesis	HPO Gene-Disease Associations	1.0	null
KLHL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94564
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.19625
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056709
PRDM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41022
infantile onset	HPO Gene-Disease Associations	1.0	null
ZNF711	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91274
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
SLC16A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57756
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.204
SLC20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23619
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08491
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60545
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.951031
GTEX-WK11-0526-SM-3NB3O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915015
Megalencephalic leukoencephalopathy with subcortical cysts	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.01
CRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.05471
paraplegia/paraparesis	HPO Gene-Disease Associations	1.0	null
KRT14	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Multiple mitochondrial dysfunctions syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14591
Perturb_14765_KD_HDAC5_SRP265842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83395
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hypotrichosis-lymphedema-telangiectasia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96651
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31714
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.927077
recurrent skin infections	HPO Gene-Disease Associations	1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02693
BRD-K65315551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13442
Lysosomal multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.599
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920726
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YTHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42438
Perturb_3502_KO_Tmem106b_SRP249535	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.09529
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07629
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25708
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06398048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44823
PDZD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27929
levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K08929846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23433
PTBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8022
CHD2	ENCODE Transcription Factor Targets	1.0	null
outer SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24176
DOV13	CCLE Cell Line Gene CNV Profiles	1.0	1.94041
hsa-miR-125b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10785552-13059_2023_3149_MOESM7_ESM.xlsx-RNAseq_HOXA9_rescue-Table_S6_The_DEGs_in_in_RBM5_KO_cells_with_HOXA9_overexpression_relative_to_RBM5_KO_control_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
ajmaline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30635
copy	GeneRIF Biological Term Annotations	1.0	null
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Developmental and epileptic encephalopathy 84	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
FKBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61221
H3K36me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75745696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12608
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
JARID2-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K77950699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46546
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
P4HA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73074
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	2.21436
ITGA2	Pathway Commons Protein-Protein Interactions	1.0	null
Monogenic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Scoliosis, Unspecified	DisGeNET Gene-Disease Associations	1.0	null
increased oligodendrocyte number	MPO Gene-Phenotype Associations	1.0	null
abnormal oligodendrocyte morphology	MPO Gene-Phenotype Associations	1.0	null
Inward rectifier potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
most	GeneRIF Biological Term Annotations	1.0	null
KLHL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70287
HOXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5436
NHLRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50583
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.9378
XRCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12926
GPATCH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86556
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12833
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
cx47cx43	GeneRIF Biological Term Annotations	1.0	null
Centrum semiovale	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
BRD-K34640380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32174
Lung adenocarcinoma_LUAD_TCGA-93-A4JN-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2792
abnormality of movement	HPO Gene-Disease Associations	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046349
EBPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14117
BRD-K66703091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36387
TRIM21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9329
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33107
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52786
oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.383637
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00612
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.30478
CCT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29895
SLMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30909
scoliosis	HPO Gene-Disease Associations	1.0	null
BRD-K17232330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24397
H3K36me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC1A5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28269391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39842
SIRT3_KO_GDS4058_16_mouse_BROWN ADIPOSE TISSUE	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30362
BRD-K46641047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83778
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03493
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07653
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Canavan Disease	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RASSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02015
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.956638
lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.919261
BRD-K85720719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27173
GTEX-XQ3S-1226-SM-4BOPP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10565
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64919
inflammatory abnormality of the skin	HPO Gene-Disease Associations	1.0	null
Zellweger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250026
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90098
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Salivary_Gland-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	1.22602
Abnormality Of Somatosensory Evoked Potentials	DisGeNET Gene-Phenotype Associations	1.0	null
hsa-miR-346	MiRTarBase microRNA Targets	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98031
Xanthomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
hsa-miR-670	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34314
BRD-K95574976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96621
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68371
USP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16099
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39786
Perturb_13506_KD_Rrp1b_SRP013709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.56697
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.685
BICR6	DepMap CRISPR Gene Dependency	1.0	2.16686
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.10776
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
abnormal motor learning	MGI Mouse Phenotype Associations 2023	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24269
Varicosity	DisGeNET Gene-Disease Associations	1.0	null
BRD-K03305572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28316
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949576
BRD-K85572169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21331
NCIH526	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39648
myelin sheath	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GATA2-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55375
disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2723
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6282
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Choreoathetosis	DisGeNET Gene-Disease Associations	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42541
CRCGN014_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04917
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00888
brain	GTEx Tissue Gene Expression Profiles	1.0	1.30423
BRD-K87191742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88938
Barrett's esophagus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
KLK3	Pathway Commons Protein-Protein Interactions	1.0	null
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.01401
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
atrophy/degeneration affecting the central nervous system	HPO Gene-Disease Associations	1.0	null
sensorineural hearing impairment	HPO Gene-Disease Associations	1.0	null
Encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
pelizaeus	GeneRIF Biological Term Annotations	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0139
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879666
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27492
abnormality of the curvature of the vertebral column	HPO Gene-Disease Associations	1.0	null
hsa-miR-4739	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3333
GTEX-XUW1-0226-SM-4BOOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17275
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93374700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79793
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96181
Cerebral Atrophy	DisGeNET Gene-Disease Associations	1.0	null
Varicose veins	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
Lateral loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.078
RB1_KD_GSE50532_656_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.4776
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58688
TCP10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26109
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.28303
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38509
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12677
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51487
OLIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23449
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19406
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50691
PAGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95734
NEMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9128
after	GeneRIF Biological Term Annotations	1.0	null
Abnormal Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27118
response to chemical	GO Biological Process Annotations 2015	1.0	null
gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486716
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27701
NUDT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33686
Lung adenocarcinoma_LUAD_TCGA-97-7941-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.881523
ZNF629	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4542
Hereditary lymphedema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.546
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14199
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866276
Leukodystrophy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PYCARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73455
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25226
DNALI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05625
PCIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69154
paranodal junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.762707
abnormality of head or neck	HPO Gene-Disease Associations	1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52514
main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.50879
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828439
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUDT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22924
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36191
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881178
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB453	DepMap CRISPR Gene Dependency	1.0	7.94886
ZBTB16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99433
abnormality of the face	HPO Gene-Disease Associations	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62673
BRD-K43086600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66258
Predominantly Lower Limb Lymphedema	DisGeNET Gene-Phenotype Associations	1.0	null
CLPP_KO_GDS4791_377_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47078
CREM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28156
MFSD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96215
Synaptic cleft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.157
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76042
abnormal involuntary eye movements	HPO Gene-Disease Associations	1.0	null
PMC12271188-Table_3.XLSX-total-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K4-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39613696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39262
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
disrupt	GeneRIF Biological Term Annotations	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
POGK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17246
EGR1	ChEA Transcription Factor Targets	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.74968
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97147
HNRNPLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21709
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3091
abnormality of facial soft tissue	HPO Gene-Disease Associations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F8-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral hypomyelination	HPO Gene-Disease Associations	1.0	null
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859328
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21635
abnormal pyramidal signs	HPO Gene-Disease Associations	1.0	null
OTULINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77083
SARS-CoV MA15_Day2_None_GSE49262	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.43565
TRPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43725
LS 174T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34589
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UT-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.903786
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12214
PMC11932929-41388_2024_3264_MOESM4_ESM.xlsx-p_0_05_FC_0_5_n_675-Differentially_expressed_genes_in_MCF7_AR-isolated_BCSCs_after_4_days_GSK591_500nM_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DHTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67471
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925484
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PCDHB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2615
SUPHD1	CCLE Cell Line Gene CNV Profiles	1.0	1.71819
sensory neuropathy	HPO Gene-Disease Associations	1.0	null
METAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06775
Perturb_3498_KO_Tmem106b_SRP249535	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.12392
pmld	GeneRIF Biological Term Annotations	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04268
EPHB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40773
cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89555
WDR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93115
clomifene-6648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1571
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7255-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oligodendrocytic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
Sensory Neuropathy	DisGeNET Gene-Disease Associations	1.0	null
TEX261	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38809
CTAGE5	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4260	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21603
Gap junction assembly	Reactome Pathways 2014	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058095
EGR1	ENCODE Transcription Factor Targets	1.0	null
Astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.486
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06995
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	82.377
genetic	GeneRIF Biological Term Annotations	1.0	null
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69705
GINS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22724
BHLHE23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35739
COL16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72263
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904422
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16696
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTGER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62514
GTEX-RU1J-0526-SM-46MUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11551
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.873748
BRD-K86155080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50278
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.94889
FN1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2593
RHOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91677
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cns hypomyelination	HPO Gene-Disease Associations	1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWN1-2026-SM-48TD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10828
IFITM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6632
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
Leukodystrophy, Hypomyelinating, 2	CTD Gene-Disease Associations	1.0	2.88009
PANK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83858
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1743
Prostate adenocarcinoma_PRAD_TCGA-G9-6333-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vasculature-lymphatic endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	1.49403
Sensory Axonal Neuropathy	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K16988512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69599
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13522
BRD-K50129495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28982
SELENOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33247
BRD-K83916197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19075
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40377
PLA2G4F	Pathway Commons Protein-Protein Interactions	1.0	null
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96995
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053615
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53712
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7052
Weight Loss	CTD Gene-Disease Associations	1.0	1.23743
Internal capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.739
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNMT3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5498
BRD-K17062413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.90518
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9573
PHF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60161
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2313
CW9019	DepMap CRISPR Gene Dependency	1.0	2.04115
FAM171B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38803
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A718-01A-22R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7217064-IJC-146-3354-s004.xlsx-Table_S5-Supplementary_Table_S5_Genes_significantly_upregulated_in_OC2-transfected_AGS_cell_compared_to_control_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ZBTB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34667
BRD-K94275706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24256
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11712
cx47cx47	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5068
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.236
H4K20me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain capillary endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.389
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
VMA21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84069
CCDC87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6947
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
connexon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.838269
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872669
Lymphedema Praecox	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5645-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.587
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.889817
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58196
BRD-K90366266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38548
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.122299
BLVRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23234
FAM111B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8345
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33715
Brain Lower Grade Glioma_LGG_TCGA-HT-7881-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
astrocytes	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.4303
Pelizaeus-Merzbacher disease	ClinVar Gene-Phenotype Associations 2025	1.0	null
KCNE5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28613
Cerebral gray matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.064
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
Nanog_KD_GDS1824_134_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.027
Benign perivascular tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916945
BRD-K30310008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49279
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal blood cell morphology/development	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-1321	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K93248080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0979
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4019
CH157MN	DepMap CRISPR Gene Dependency	1.0	2.73688
ZNF80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60566
Perturb_4177_KO_Dnmt1_SRP043000	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K17649115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02717
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.488
Glomangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.068382
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.81849
Impaired Cognition	DisGeNET Gene-Disease Associations	1.0	null
Syncytium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.235
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18263
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MT1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96869
abnormality of the skin	HPO Gene-Disease Associations	1.0	null
AKIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7062
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978152
abnormal nerve conduction velocity	HPO Gene-Disease Associations	1.0	null
Rectum adenocarcinoma_READ_TCGA-AH-6644-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Autosomal recessive spinocerebellar ataxia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12665
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041099
abnormality of the globe	HPO Gene-Disease Associations	1.0	null
TSSK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16493
directly	GeneRIF Biological Term Annotations	1.0	null
hESC_Derived_CD56+_Mesoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.954094
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CCDC74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69408
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
HABP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44223
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59497
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059441
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02881560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28191
BRD-K98749544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91108
SRSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4571
BRD-K67177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16438
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood-brain barrier	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.345
EGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18371
AGPAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80033
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81244
GATA1_G1E-ER4_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.76065
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03852
ZSCAN5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57791
HNRNPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84097
MET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98701
KIAA0232	Pathway Commons Protein-Protein Interactions	1.0	null
AMPA glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.187
Septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.988
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32681
DICER1_KO_GDS4504_582_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
efo21	HPA Cell Line Gene Expression Profiles	1.0	1.94752
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20579
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59958
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.825768
GSE234514,GSE234516_2_v_0_mitf_human	RummaGEO Gene Perturbation Signatures	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050488
CGRP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.529
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61246
PCWH syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.860997
abnormality of skeletal morphology	HPO Gene-Disease Associations	1.0	null
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05015
skeletal muscle cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270214
NT5C3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95497
ZNF232	Pathway Commons Protein-Protein Interactions	1.0	null
PRKAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18095
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGRMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44549
abnormal nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
CSNK2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86025
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.23995
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.219
ADRA1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74597
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17852
GI1	DepMap CRISPR Gene Dependency	1.0	3.11431
ATM	Pathway Commons Protein-Protein Interactions	1.0	null
TBC1D25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76973
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39074860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01635
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7068
Hypomyelinating leukodystrophy 16	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.003
SIRT3_KO_GDS4058_454_mouse_BROWN ADIPOSE TISSUE	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18709210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40004
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03814
likely	GeneRIF Biological Term Annotations	1.0	null
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	6.65472
central medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07687
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39572
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31818
SPOUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38274
CHAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03086
reported	GeneRIF Biological Term Annotations	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
form	GeneRIF Biological Term Annotations	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6875
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71234
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963893
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056749
ZNF263_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.74941
Anchoring junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Compact myelin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.252
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26819
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.56055
FLUFENAMIC ACID	DGIdb Drug Targets 2026	1.0	0.348237
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922202
SNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47158
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.730976
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IKBKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24152
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.59318
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0614
CLSTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15211
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EYA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79468
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428783
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K31575995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04161
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42232
CLPP_KO_GDS4791_375_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K57051157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44464
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.1668
ZRANB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28949
BRD-K78007953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54021
suggested	GeneRIF Biological Term Annotations	1.0	null
neuron degeneration	MPO Gene-Phenotype Associations	1.0	null
BRD-K56738235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31125
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2013
BRD-K97946004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03964
Venous insufficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50851442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13094
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2007
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06697
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RARA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88083
LDB3	Pathway Commons Protein-Protein Interactions	1.0	null
Cataract 1 multiple types	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
Astrocyte end-foot	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
abnormal motor nerve conduction velocity	HPO Gene-Disease Associations	1.0	null
cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125609
decreased motor nerve conduction velocity	HPO Gene-Disease Associations	1.0	null
REL	JASPAR Predicted Transcription Factor Targets	1.0	null
cypermethrin	CTD Gene-Chemical Interactions	1.0	null
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31021
NRK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
Hereditary spastic paraplegia 73	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18998
Perturb_1310_KO_Cntnap4_SRP387040	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.78228
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54616
PRMT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66408
GTEX-XMD1-0011-R1A-SM-4AT4C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34428
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24612
GPX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52893
upper motor neuron dysfunction	HPO Gene-Disease Associations	1.0	null
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.894
ARHGAP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78962
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05848
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C4II	DepMap CRISPR Gene Dependency	1.0	2.21177
PNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61289
BRD-K20416270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93583
CDC45	Pathway Commons Protein-Protein Interactions	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26116
SLC30A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43313
BRD-K18368161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11649
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
TTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89672
Peroxisomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
RAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21296
abnormality of limb bone morphology	HPO Gene-Disease Associations	1.0	null
H3K36me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oculodentodigital dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.786
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55492
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Myelin sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.307
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21897482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6806
inner SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870473
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
provide	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal locomotor behavior	MPO Gene-Phenotype Associations	1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.908731
bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.076631
SNAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35967
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.871386
HCC2998	GDSC Cell Line Gene Expression Profiles	1.0	1.46912
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AHSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22147
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.95133
KANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07627
PYDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26057
GTEX-OHPK-0526-SM-2HMJB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82714
SCABER	DepMap CRISPR Gene Dependency	1.0	5.09067
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.62719
TNFRSF13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39368
Urinary Bladder Sphincter Dysfunction	DisGeNET Gene-Phenotype Associations	1.0	null
PTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91041
CFD	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05386
Babinski Reflex	DisGeNET Gene-Phenotype Associations	1.0	null
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.156342
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal cerebellum white matter morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K57270624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47404
cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.158144
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hereditary lymphedema IA	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.096
abnormality of the ear	HPO Gene-Disease Associations	1.0	null
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947508
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51704
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.76399
GTEX-WL46-0426-SM-3TW8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04671
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.71925
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052741
PMC9577795__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_12030_KD_ADORA1_SRP215261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27938
BRD-K85559506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38705
UTP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.012
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05266
BRD-K43192836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3184
BRD-K60716223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1331
Chronic venous insufficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.88345
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.177
SKMEL30	DepMap CRISPR Gene Dependency	1.0	3.698
GATD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04696
BRD-K58534531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18027
BRD-K18620798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38275
DEL	CCLE Cell Line Gene CNV Profiles	1.0	1.95745
GSE254155_5_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-485-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K39809702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27151
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_JARID2_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
DMRTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57647
NMCG1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.11258
ASH1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98871
myelin sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.916243
Perturb_5703_OE_H2Aa/H2Ab1_ERP108769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.5623
Parasympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
CRCGN011_HEPG2_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41275
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU1J-1026-SM-46MUR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917716
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.642
PPARG-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073612
SW 527	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.958216
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0611
GSE190761_0_v_1_samd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870617
ECE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66715
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83668
KRT6A	Pathway Commons Protein-Protein Interactions	1.0	null
oligodendrocytes	GeneRIF Biological Term Annotations	1.0	null
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43901257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1378
SERF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51337
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Central pontine myelinolysis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4684
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
ZNF532	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68862
ZNF568	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60321
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83391
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7752
Lymphedema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.825
Pelizaeus-Merzbacher disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.01
cell communication	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22322
TUHR10TKB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72885
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3849
abnormal neuron morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K84090286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46889
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.342
CEBPD	ENCODE Transcription Factor Targets	1.0	null
progressive spasticity	HPO Gene-Disease Associations	1.0	null
PNGase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.812
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84846
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypomyelinating leukodystrophy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
BRD-K72066653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13843
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.244345
PEG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46691
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DENND11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91305
SV2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83334
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835115
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03032
Head Titubation	DisGeNET Gene-Phenotype Associations	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.743389
primary	GeneRIF Biological Term Annotations	1.0	null
BRD-K12925598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2301
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39393
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250026
Sciatic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.356
MDK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86016
TMEM219	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64757
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054867
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72205
Cerebral peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
PMC12271188-Table_3.XLSX-CTD-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93958
myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124915
junction	GeneRIF Biological Term Annotations	1.0	null
NR2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13236
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.172
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIAM1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.72605
20460542-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Hypomyelinating leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.234
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04721
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41432
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
vestibular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06254
BRD-K64245731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42906
RAB6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3199
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45067
GATA1	ChEA Transcription Factor Targets	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TIGAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94669
PAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96702
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18657
CTCFL	ENCODE Transcription Factor Targets	1.0	null
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3BM-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMPD3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72964
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
Perturb_6370_KD_ETV1_SRP124661	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78934
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07504
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12848
PMC3804941-supp_jem.20122709_JEM_20122709_TableS1.xlsx-Suppl_Table_1C-1772_genes-Table_S1_C_1_772_significantly_overexpressed_genes_during_AR_when_combining_p-values_at_FDR_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
UBE2L6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68787
SARS-CoV MA15_Day2-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.0967
Cerebellar Signs	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78612
BRD-K96154586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53691
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.24225
mutant	GeneRIF Biological Term Annotations	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0628
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COMMD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57829
FOXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18441
MTERF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22479
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16476
A-CA-04-2009(H1N1)_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.07674
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1358
Satellite glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.021
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Movement Disorders	CTD Gene-Disease Associations	1.0	1.23265
C8orf82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35718
BRD-K53634892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34968
PPBP	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Caudate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.30357
Hereditary spastic paraplegia 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epiphysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.471927
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31335
Gap junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
ALB	Hub Proteins Protein-Protein Interactions	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54573
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03039
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14156
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01311880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09147
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56950366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7624
Chromosome 18q deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.95
THUMPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60769
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.950305
hypoactivity	MPO Gene-Phenotype Associations	1.0	null
BRD-K21864149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03263
SKLMS1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76875
Rad51C-XRCC3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.577
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.667
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-1326-SM-4LMI9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14891
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87536
Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM231	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42097
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61904
Cardiovascular organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.55107
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
16455954-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MOGGUVW	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03126
Type 2 diabetes mellitus_Pancreas_GSE2470	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.29496
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11818
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
E2F6	ENCODE Transcription Factor Targets	1.0	null
Sensorineural Hearing Loss (Disorder)	DisGeNET Gene-Disease Associations	1.0	null
ZNF770	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52011
BRD-K49203165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43864
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13356
CCND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56081
GTPBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21053
frameshift	GeneRIF Biological Term Annotations	1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.513743
ZNF660	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34856
ITM2B-related cerebral amyloid angiopathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
SRRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22713
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935748
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.904574
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	0.947099
lateral loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.745929
Poisoning	CTD Gene-Disease Associations	1.0	1.15324
URM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31192
Cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.971
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66766
BRD-K50685439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26914
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59583
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
noncoding	GeneRIF Biological Term Annotations	1.0	null
abnormal macrophage morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20158
Hair disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
DHX35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67497
SIGIRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71598
PMC10322841-41598_2023_38117_MOESM7_ESM.pdf-9-FOXF1_FOXF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-403-MYCL_MYCL	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2543
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77702
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.230601
chorea-acanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.868777
GSE156115_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39600742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12231
SS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.26742
TEX45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14495
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63065496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58804
BRD-K18599462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15902
RBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11139
Ataxia	DisGeNET Gene-Disease Associations	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
altered	GeneRIF Biological Term Annotations	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
TNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44576
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0847
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4731
VCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15045
YKG1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53367
Schmidt-Lanterman incisure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.022
SW962	GDSC Cell Line Gene Expression Profiles	1.0	1.99963
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the lower urinary tract	HPO Gene-Disease Associations	1.0	null
TFAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
demyelinating	GeneRIF Biological Term Annotations	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07646
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of the metencephalon	HPO Gene-Disease Associations	1.0	null
TBX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68199
ZNF518B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66288
synostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.217352
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cellulitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
krt7_21596846_megakaryocyte_progenitor_bone_marrow_lof_mouse_gpl6105_gse24969	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.45346
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44675576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80409
DNASE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29043
chromosomal	GeneRIF Biological Term Annotations	1.0	null
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of eye movement	HPO Gene-Disease Associations	1.0	null
Hereditary spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
LN464	CCLE Cell Line Gene Expression Profiles	1.0	1.5625
microgliosis	MPO Gene-Phenotype Associations	1.0	null
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05729
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03316
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99475
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
recessive	GeneRIF Biological Term Annotations	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.865967
BRD-K23200057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60909
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.4746
head titubation	HPO Gene-Disease Associations	1.0	null
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.856636
lead	GeneRIF Biological Term Annotations	1.0	null
BRD-K58964288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26847
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868359
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18446
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.842
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18214
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96941
H2BC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10194
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	0.996007
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67989
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32632
KDSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78485
increased astrocyte number	MPO Gene-Phenotype Associations	1.0	null
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995985
SSTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42923
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55552
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897878
lymphedema-distichiasis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.953
IKZF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68904
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.6935
DQX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37902
Hypomyelinating leukodystrophy 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.904
H3K36me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary lymphedema I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.264
FOXI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34088
red nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.91804
JUP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68334
UFSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6208
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9873
hsa-miR-4749-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
KANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48995
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
Microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.959
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZY-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895424
CBLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3936
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-COMMON_KD-DOWN_and_OE-UP-109_common_elements_in_kd-down_and_oe-up_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26994486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44228
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.9632
OXSM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
channels	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4319	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.4903
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG7-1226-SM-4LMK2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84484
abnormality of the optic disc	HPO Gene-Disease Associations	1.0	null
degeneration	GeneRIF Biological Term Annotations	1.0	null
BRD-K32418104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99374
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82513
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
RFXAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47476
FUT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74353
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sphingolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.736
Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	279.607
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HS936T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47405
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.988697
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF4G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13021
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947321
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44002
Anchoring junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.493
HIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36597
TOX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2358
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Palmoplantar keratoderma and congenital alopecia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
RBBP5	ENCODE Transcription Factor Targets	1.0	null
WDR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77845
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25489
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881178
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864626
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.16209
TAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18317
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21249
Brain capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMIM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05504
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3472
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58746
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89912
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5542
SETDB1	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6459
endosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.19307
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.34352
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Hypomyelinating leukodystrophy 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.984
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC1SQ	DepMap CRISPR Gene Dependency	1.0	2.70587
GTEX-U3ZH-1126-SM-4DXUG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978672
abnormal mononuclear phagocyte morphology	MPO Gene-Phenotype Associations	1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gap junction trafficking	Reactome Pathways 2014	1.0	null
Plant collar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.349
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78291
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34647
GTEX-RNOR-1326-SM-48FDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10372
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7749
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99134
BRD-K08043579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05491
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
gliosis	MPO Gene-Phenotype Associations	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
abnormal cerebellar cortex morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K75539052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05257
NFYA_02_76	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62413
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZC3H11A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976641
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64658
left colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223906
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6094
UMRC6	CCLE Cell Line Gene Expression Profiles	1.0	2.07031
C2orf81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11998
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0626-SM-4KL1S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978618
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.930765
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70696
abnormality of refraction	HPO Gene-Disease Associations	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.53258
gut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074508
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal brain morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08909
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
wide pore channel activity	GO Molecular Function Annotations 2025	1.0	null
TBL1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38313
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.7947
C8G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28151
hela cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.692085
Perturb_1172_KD_CBFB_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3776465__F2	PFOCR Pathway Figure Associations 2023	1.0	null
TLR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18674
Lymphedema	HuGE Navigator Gene-Phenotype Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RICTOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52878
BRD-K54100199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11733
response to stimulus	GO Biological Process Annotations 2015	1.0	null
abnormality of the cerebrum	HPO Gene-Disease Associations	1.0	null
Autosomal recessive craniometaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
TTYH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31623
CHKB	Pathway Commons Protein-Protein Interactions	1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02624
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
shows	GeneRIF Biological Term Annotations	1.0	null
ZNF282	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64137
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56165
CALCOCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39741
BRD-K32403186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66881
GRSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15106
SP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63992
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5196-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.884732
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.122
VASH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81614
APOC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11131
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81471597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11486
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1675
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YK-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0439
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.6627
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
decreased vertical activity	MGI Mouse Phenotype Associations 2023	1.0	null
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059619
Hypogonadotropic hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
Bladder-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	-0.0757305
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AA-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
weakness due to upper motor neuron dysfunction	HPO Gene-Disease Associations	1.0	null
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.441
HEK 293T	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11302
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20415
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vasculature-endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	3.10208
BRD-K64859133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93193
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29554
JKAMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35376
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25904
APOC3	Pathway Commons Protein-Protein Interactions	1.0	null
Filariasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
Hypomyelinating leukodystrophy 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.078
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RANGRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2551
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-1026-SM-48FCO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884957
PPARG-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87699
TMCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92803
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907594
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.41295
ERCC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02729
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92862
demyelinating peripheral neuropathy	HPO Gene-Disease Associations	1.0	null
SH3BP5	Pathway Commons Protein-Protein Interactions	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.67838
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089842
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06185
Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20153
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60121
NCIH1944	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56435
hsa-miR-612	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16266179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29657
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4730-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34863
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.940049
PDE4B	Pathway Commons Protein-Protein Interactions	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56193
Tooth agenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.63
SLIRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44164
BRD-K28694162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34526
GTEX-VUSG-1026-SM-4KKZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949023
Myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.281
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57786075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26572
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954623
GM2 gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
ANGEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56338
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58705
CTCF	ChEA Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28795
BRD-K73042446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10273
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.06623
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33521
GSE129241_1_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09204
HCC95	DepMap CRISPR Gene Dependency	1.0	4.88846
Hypomyelinating leukodystrophy 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.992
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74954
SLC9A8	Pathway Commons Protein-Protein Interactions	1.0	null
Sensorineural hearing loss	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tongue	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23255
Perturb_8637_KO_Arid1a_SRP312002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.68187
SAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1199
leukodystrophies	GeneRIF Biological Term Annotations	1.0	null
CLPP_KO_GSE40207_379_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22194
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IQ-01A-31R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52101275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36918
OBSL1	Pathway Commons Protein-Protein Interactions	1.0	null
Node of Ranvier	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.834
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05124
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.985
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
B3GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07339
GSE145915_0_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	2.88803
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93619
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
BRD-K66189308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33722
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1679
JMJD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27113
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
flurbiprofen-4674	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46705
GTEX-T2IS-2226-SM-4DM65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.476
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17174
Minocycline	CTD Gene-Chemical Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-8454-11A-01R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08128
HOXC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50774
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05909
Ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39695
GCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49307
Gordon Holmes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
Embryonic cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.918647
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83094
HDHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1754
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10174
abnormal cerebellum white matter morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909057
BRD-K79688948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26209
Sandhoff disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
AHR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8502
Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86345
Pontocerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364139
LN443	CCLE Cell Line Gene Expression Profiles	1.0	1.47728
TTLL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86828
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27113
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61095
hsa-miR-4784	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848822
BRD-K45142472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56904
BRD-K18352607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27678
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54867
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.961159
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921822
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54585
WWP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51455
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28351377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19954
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7088
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8443-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07274638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03172
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02305
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223906
MIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4065
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MSGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76718
Saphenous vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
signaling	GO Biological Process Annotations 2015	1.0	null
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084781
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39772
PRDM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49608
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16195
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
SHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15462
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.892736
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.11081
POLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8369
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07694
PRRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82013
already	GeneRIF Biological Term Annotations	1.0	null
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Dysarthria	DisGeNET Gene-Disease Associations	1.0	null
GSE130715_1_v_0_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1267
OVOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42741
BCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60438
BRD-K40016301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02734
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.68322
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K48999921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53668
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.4327
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32975
canavan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.793771
Ionotropic glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.236
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78605
POLR2A	ENCODE Transcription Factor Targets	1.0	null
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45262
Hypomyelinating leukodystrophy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
BRD-K69393995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19378
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30751
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NUAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60304
Metachromatic leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.954
H3K36me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8028
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TSPAN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04345
GOPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7943
abnormal myelination	HPO Gene-Disease Associations	1.0	null
UMRC7	DepMap CRISPR Gene Dependency	1.0	4.90641
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836898
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-2026-SM-3LK7U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11053
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862438
JIMT1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73892
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19617
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21349
TMEM184C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93919
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928259
abnormality of hindbrain morphology	HPO Gene-Disease Associations	1.0	null
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP1A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05511
BRD-K15008902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19883
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89121
GTEX-PX3G-0726-SM-48TZT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926276
ODR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00772
SFXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99654
neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.382223
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.32015
kidney_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.957636
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
spastic paraplegia 44, autosomal recessive	OMIM Gene-Disease Associations	1.0	null
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08147
BSX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40982
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.6751
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09458
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB69	DepMap CRISPR Gene Dependency	1.0	2.39998
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.487
PMC9999213-mmc3.xlsx-DEGs_CSc-DEA_NB_MSC_EC_CSc_vs_NB_CSc_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Hereditary spastic paraplegia 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Dystonia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K89537738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12079
NT5DC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7047
pathologic nystagmus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.916375
BARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72461
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K36me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829147
BRD-K90127324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09344
BRD-K69903018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27544
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898689
BRD-K02420839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50441
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4665
BRD-K33122655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67637
GTEX-T5JC-1926-SM-4DM6Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19077
autosomal dominant inheritance	HPO Gene-Disease Associations	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormality of the posterior segment of the eye	HPO Gene-Disease Associations	1.0	null
BRD-K18304318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48708
BRD-K66248685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04374
RAD21	ENCODE Transcription Factor Targets	1.0	null
JARID2-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K24659381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22847
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Erythrokeratodermia variabilis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47676
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.30375
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41146
KPNYS	DepMap CRISPR Gene Dependency	1.0	3.24211
CLPP_KO_GSE40207_381_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
neuroacanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.824128
Glycogen storage disease III	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
GTEX-O5YV-1826-SM-2YUNI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921446
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5802
HCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63789
TOLLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19026
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.827926
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01271
CFH	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
than	GeneRIF Biological Term Annotations	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90171
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8838
endometrium_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.906949
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.945505
TWF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50391
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046181
Acute Myeloid Leukemia_LAML_TCGA-AB-2887-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NTMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83647
CDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3395
DDX55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04935
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29292
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03454
SERF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37184
BRD-K49528360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11851
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.385143
ethinyl estradiol_oryzias latipes_gpl16266_gse44859	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88608
breast	GeneRIF Biological Term Annotations	1.0	null
NRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38062
BEND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39567
M14	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.13187
cell communication	KEGG Pathways	1.0	null
Cerebral Hypomyelination	DisGeNET Gene-Phenotype Associations	1.0	null
RAB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92351
C4orf3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72352
GINS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31882
THRAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00074
gja1	GeneRIF Biological Term Annotations	1.0	null
SDHAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57387
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49721
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882662
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ACSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58383
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23501
Eye-ocular surface cell	Tabula Sapiens Gene-Cell Associations	1.0	0.268852
tremor	HPO Gene-Disease Associations	1.0	null
Combined saposin deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
MAZ	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2661-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34179
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3447
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832577
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.11378
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
UBTF	ENCODE Transcription Factor Targets	1.0	null
HOXA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83823
AGA	Pathway Commons Protein-Protein Interactions	1.0	null
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885433
PMC10335677-pbio.3002161.s010.xls-SETD1A_KD-Cell_Cycle_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39569
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
METTL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60679
SEMA5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32533
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37256
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.58891
NR2E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15938
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840142
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26503
Toenail Dysplasia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
brain myelin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.735147
abnormality of the abdomen	HPO Gene-Disease Associations	1.0	null
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55921
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17438
KRT6B	Pathway Commons Protein-Protein Interactions	1.0	null
Bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of connective tissue	HPO Gene-Disease Associations	1.0	null
Synostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31525
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spinal cord disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.6
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9745
NB6	DepMap CRISPR Gene Dependency	1.0	2.48012
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11688
poor speech	HPO Gene-Disease Associations	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.905754
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17367110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25273
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99777
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844585
E2F4	ENCODE Transcription Factor Targets	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21724
Axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.012
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.37505
BRD-K35616138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31478
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
GATA1-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCIH508	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39806
fallopiantube_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.4705
CLPP_KO_GDS4791_539_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
thigh muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.10974
Barrett's esophagus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.864
SFPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89495
HS821T	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02216
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.53086
BRD-K58412301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65972
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
functional abnormality of the bladder	HPO Gene-Disease Associations	1.0	null
Hypomyelinating leukoencephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.848
HM7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.87097
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Edema	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K38719699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06612
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28417
RNPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97338
GSE234767,GSE234769_0_v_1_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02972
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-CoV MA15_Day2-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.87616
alverine-1426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTPBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39327
BRD-K78983822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04181
alterations	GeneRIF Biological Term Annotations	1.0	null
Perturb_16432_OE_E2f4_SRP327850	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.0223
KMS26	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8964
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A69P-06A-21R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hypomyelinating leukodystrophy 22	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.744
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14584
PHYHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67354
BRD-K43473008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8655
Lateral vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90269
Lung adenocarcinoma_LUAD_TCGA-55-8619-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7602-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050283
abnormal leukocyte morphology	MPO Gene-Phenotype Associations	1.0	null
DICER1	Pathway Commons Protein-Protein Interactions	1.0	null
SPAST	Pathway Commons Protein-Protein Interactions	1.0	null
CDK2	Hub Proteins Protein-Protein Interactions	1.0	null
PMC12756533-mmc1.pdf-8-FOXO3_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04967
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25884
Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
sensory impairment	HPO Gene-Disease Associations	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCC010	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	278.878
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10587
G361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42802
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
TTR	Pathway Commons Protein-Protein Interactions	1.0	null
dysarthria	HPO Gene-Disease Associations	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7548
BRD-K31606237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07416
GRHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19482
Hypomyelinating leukodystrophy 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33277
NCI-H1048	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23724
inner ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263327
BRD-K11566982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32654
BRD-K28698418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45461
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myelin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.642
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59497
abnormal glial cell physiology	MPO Gene-Phenotype Associations	1.0	null
SEC61A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63642
abnormal learning/memory/conditioning	MPO Gene-Phenotype Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828387
H3K36me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.862332
DPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98231
FAM71E2	Pathway Commons Protein-Protein Interactions	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LN428	CCLE Cell Line Gene Expression Profiles	1.0	1.75902
Brain Lower Grade Glioma_LGG_TCGA-DB-A64V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32856496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30126
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1304	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PTPN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56533
RIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47495
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1964
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Corpus callosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.209
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.937435
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944674
Fetal Lung	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.25909
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphatic malformation	ClinVar Gene-Phenotype Associations 2025	1.0	null
Cerebrotendinous xanthomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96526
BRD-K93223696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29648
cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.4856
S100A16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94671
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.949785
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00474
HDAC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1341
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37434
hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.3773
BRD-K93615384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15324
Quadriplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.438
IGF2BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94152
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3691
15q11q13 copy number variation	WikiPathways Pathways 2024	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.08757
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0614
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.17679
TRMT10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84624
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71626
PMC3938256__F1	PFOCR Pathway Figure Associations 2023	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63901
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.477151
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30269
abnormality of higher mental function	HPO Gene-Disease Associations	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SREBF1_SREBF1	Rummagene Transcription Factor Associations 2026	1.0	null
SPRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15808
ADCY9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51073
astrocytes	GeneRIF Biological Term Annotations	1.0	null
PRPF38A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90368
Junctional zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.051
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446807
H3K36me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55751
RCC10RGB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83791
abnormality of the nervous system	HPO Gene-Disease Associations	1.0	null
hyperreflexia	HPO Gene-Disease Associations	1.0	null
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1188
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07333
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	6.04203
purkinje cell degeneration	MPO Gene-Phenotype Associations	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29625
MOB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56753
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C8166	DepMap CRISPR Gene Dependency	1.0	2.6069
onset	HPO Gene-Disease Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46H-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00997
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PARPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.46968
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
allele	GeneRIF Biological Term Annotations	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0215
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2312
BRD-K84118789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38792
BATF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0286
BRD-K20398543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22572
Abnormal Auditory Evoked Potential	DisGeNET Gene-Phenotype Associations	1.0	null
Leading edge membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.461
BRD-K34158806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12441
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.838412
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.45775
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.7165
leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077484
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13145
TRAPPC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12221
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68742
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
presenting	GeneRIF Biological Term Annotations	1.0	null
MRPL51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93358
PTRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19992
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33672
carrying	GeneRIF Biological Term Annotations	1.0	null
abnormal hindbrain morphology	MPO Gene-Phenotype Associations	1.0	null
Hereditary spastic paraplegia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.1
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD79B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90974
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.819
connexin complex	GO Cellular Component Annotations 2025	1.0	null
spastic gait	HPO Gene-Disease Associations	1.0	null
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7775
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tongue-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	0.0774171
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.46785
GSE171826_1_v_0_rosiglitazone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MBD4	ENCODE Transcription Factor Targets	1.0	null
CAL120	DepMap CRISPR Gene Dependency	1.0	2.30829
BRD-K25330450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73022
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney Chromophobe_KICH_TCGA-KN-8434-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thorny excrescence	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.984324
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.27157
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55136
H3K36me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spastic ataxia 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.965
MITF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11217
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4566
JARID2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-361-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.856356
morphological abnormality of the central nervous system	HPO Gene-Disease Associations	1.0	null
Oligodendrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.28289
astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.0996
Hereditary spastic paraplegia 35	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.002
ZC3H15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31022
BRD-K13320013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28184
GPAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59735
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40595
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
resulting	GeneRIF Biological Term Annotations	1.0	null
motor polyneuropathy	HPO Gene-Disease Associations	1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894502
LYSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50086
abnormal vertical activity	MPO Gene-Phenotype Associations	1.0	null
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920803
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932368
DCD	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07168
Orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.965
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11599
abnormality of the cerebral white matter	HPO Gene-Disease Associations	1.0	null
BRD-K54089081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31974
ARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73508
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74736
hsa-miR-149	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
inner SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833778
Optic neuritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20797
CCDC124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48373
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927721
Tek	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
Perikaryon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.974
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.954119
Perturb_8584_OE_Sorl1_SRP261088	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.14085
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75582
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17702
PANX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52951
Meige syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5248
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3339
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903517
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23767
chinese	GeneRIF Biological Term Annotations	1.0	null
BRD-K44141416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1101
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21602
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10335677-pbio.3002161.s010.xls-SETD1A_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-1226-SM-4DXSV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954554
she	GeneRIF Biological Term Annotations	1.0	null
PABIR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84484
SLC16A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66662
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.401386
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875399
PLPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51489
troglitazone-6191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88128293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16782
HCC2814	CCLE Cell Line Gene Expression Profiles	1.0	2.05326
Prostate adenocarcinoma_PRAD_TCGA-M7-A71Y-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.967657
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.08881
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040594
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
network	GeneRIF Biological Term Annotations	1.0	null
BOLA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93282
BRD-K07464613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85895
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21439
Tachycardia_Myocardial tissue_GSE7999	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.30245
CD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7503
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	3.08832
Facial Paralysis	DisGeNET Gene-Disease Associations	1.0	null
MAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78632
rare	GeneRIF Biological Term Annotations	1.0	null
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069849
BmN4-SID1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08438
BRD-K62497619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32253
GLDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74597
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.141
MALME 3M	BioGPS Cell Line Gene Expression Profiles	1.0	1.37644
all	HPO Gene-Disease Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-AAQO-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99969
Ankle Edema (Finding)	DisGeNET Gene-Phenotype Associations	1.0	null
C9orf78	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0238
RCOR1	ENCODE Transcription Factor Targets	1.0	null
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.864961
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3095
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34095
flufenamic acid	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.673328
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
upper limb spasticity	HPO Gene-Disease Associations	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224613
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.27316
abnormal oligodendrocyte physiology	MGI Mouse Phenotype Associations 2023	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.40137
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11903305-41586_2024_8507_MOESM3_ESM.xlsx-Table_S1_MAF-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal hematopoietic system morphology/development	MPO Gene-Phenotype Associations	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880053
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27732
SERPING1	Pathway Commons Protein-Protein Interactions	1.0	null
LZTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3503
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20517
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32518
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.911109
CRCGN015_MCF10A.TP53.M_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44575
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877987
CBX3	ENCODE Transcription Factor Targets	1.0	null
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7467-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05408
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5489-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23236
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844392
hmc1	HPA Cell Line Gene Expression Profiles	-1.0	-1.1994
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.0938
Hemangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
GGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10859
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MALSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77489
number	GeneRIF Biological Term Annotations	1.0	null
BRD-K29468949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17366
Alexander disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.134
ZBTB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31552
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949576
Ensheathing process	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.733
FAM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50122
BRD-K08241590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23849
SEPTIN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68569
Hypomyelinating leukodystrophy 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
Meninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067942
GSE114553_0_v_1_lhx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
H1-10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14438
LASP1NB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80581
APOC2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33869336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39934
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
neurodevelopmental abnormality	HPO Gene-Disease Associations	1.0	null
plp1related	GeneRIF Biological Term Annotations	1.0	null
GTEX-NL4W-0011-R2a-SM-2I5GV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64906
PRC2_EZH2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
CACNA1I	Pathway Commons Protein-Protein Interactions	1.0	null
AGXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58494
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.92785
decreased vertical activity	MPO Gene-Phenotype Associations	1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SLC18B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78651
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842941
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.918096
TERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59294
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATOH7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56848
plp1	GeneRIF Biological Term Annotations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34454
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
RCOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8304
NID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2043
compact myelin	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.832302
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leading	GeneRIF Biological Term Annotations	1.0	null
GTEX-SNOS-0426-SM-32PMH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825765
PPOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65057
visual pathway disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.210925
GTEX-OHPL-2026-SM-3TW8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1208
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.879
IMPDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45435
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987538
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92482
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH650	DepMap CRISPR Gene Dependency	1.0	3.71731
Megalencephalic leukoencephalopathy with subcortical cysts 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.835
PKN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35072
BRD-K89767945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61674
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MY-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36795325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37894
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37862
Hereditary spastic paraplegia 44	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.336
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1147
RNASE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39621
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23015
BRD-K36468214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48638
PK59	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66318
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94Y-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044703
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29808
EZH2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PELI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72011
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06330738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4037
SMC3	ENCODE Transcription Factor Targets	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR751	CCLE Cell Line Gene CNV Profiles	1.0	2.33645
BRD-K66311249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0068
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01117
H3K36me3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A71933035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24566
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K40143134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40258
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8006
H3K4me1_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53653
CCDC71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76428
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-6867-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898759
BRD-K61687409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3028
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28228
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28208
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61353
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
TC32	CCLE Cell Line Gene CNV Profiles	1.0	1.45394
SPRR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57296
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08303
MARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10855
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73311
T/C-28a2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
IFT80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53331
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6187
Gastroesophageal junction	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
GABPA	ENCODE Transcription Factor Targets	1.0	null
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62702
facts	GeneRIF Biological Term Annotations	1.0	null
CBX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87273
BRD-A89554862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51889
BRD-K58112932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29622
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34097
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.879109
ZNF512	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35996
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Optic Atrophy	DisGeNET Gene-Disease Associations	1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
BRD-K28071390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04154
CLPP_KO_GDS4791_106_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20966
TBX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55736
BRD-K13970506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43846
SCAF1	Pathway Commons Protein-Protein Interactions	1.0	null
sensory axonal neuropathy	HPO Gene-Disease Associations	1.0	null
Myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.649
ASMTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14155
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060838
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDCP1	Pathway Commons Protein-Protein Interactions	1.0	null
LANCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79341
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.23922
sensory peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.448064
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19575490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36465
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934977
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10321
LRP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19588
PRECLH	CCLE Cell Line Gene Expression Profiles	1.0	1.70161
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.944904
Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.066
ITGB5	Pathway Commons Protein-Protein Interactions	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.89941
UQCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77618
TP53_01_175	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58822
BRD-K24792153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24769
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-3.01261
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Myopia	DisGeNET Gene-Disease Associations	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910866
RNF216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78593
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF4V1	Pathway Commons Protein-Protein Interactions	1.0	null
PLEKHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36139
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Muscle-endothelial cell of vascular tree	Tabula Sapiens Gene-Cell Associations	1.0	1.07288
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.47437
having	GeneRIF Biological Term Annotations	1.0	null
THRAP3	Pathway Commons Protein-Protein Interactions	1.0	null
SZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.931617
consanguineous	GeneRIF Biological Term Annotations	1.0	null
Leukoencephalopathy with vanishing white matter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.874
PHLDA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21569
PSMC3IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04533
GSE200687,GSE200688_1_v_0_sox15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Elephantiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77809
Neocortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.531
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50334
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50791
ERBB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2685
BRIX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06304
distal	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q734-1626-SM-48U1B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876723
IVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30347
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22496
MDAMB453	CCLE Cell Line Gene CNV Profiles	1.0	1.58181
abnormality of the foot	HPO Gene-Disease Associations	1.0	null
vh2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
KLF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal nervous system electrophysiology	HPO Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-A44F-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SORBS3	Pathway Commons Protein-Protein Interactions	1.0	null
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3358
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880836
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
hsa-miR-4287	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC9334849-Table_3.xlsx-subcutaneous_adipose_tissue-D1_VS_D9_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36332
Anterior horn	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.485
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02424
GTEX-R55D-1526-SM-48FEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935787
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29611
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
test	GeneRIF Biological Term Annotations	1.0	null
GTEX-QV44-1026-SM-447CG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02173
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90848
Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055711
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989034
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17052
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.2578
CRCGN017_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29177
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910866
ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.18177
SW948	DepMap CRISPR Gene Dependency	1.0	8.57396
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal cerebellum morphology	MPO Gene-Phenotype Associations	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.29985
NBPF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75641
Perturb_12523_KD_Linc00673_SRP212104	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Brain Lower Grade Glioma_LGG_TCGA-QH-A65V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36523261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07507
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21156
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68289
TDRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8689
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895358
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47974
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
SK-CO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UM-UC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.28289
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62554329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0955
DUSP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41647
described	GeneRIF Biological Term Annotations	1.0	null
extremely	GeneRIF Biological Term Annotations	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50954
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15301
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neurodegeneration	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K34254821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09186
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2366
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	148.003
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869479
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05967
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35146
result	GeneRIF Biological Term Annotations	1.0	null
KE37	DepMap CRISPR Gene Dependency	1.0	2.28076
Progressive Cerebellar Ataxia	DisGeNET Gene-Disease Associations	1.0	null
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835195
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0426-SM-2TC65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964246
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90679
Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal dominant nonsyndromic deafness 2B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
IFNGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64181
BRD-K13411423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46055
POLDIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50396
SNU407	CCLE Cell Line Gene CNV Profiles	1.0	1.67364
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.963
posteroventral (inferior) parietal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.973064
H2AC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83727
H1-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1114
DERL1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF891	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67608
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56354
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCTD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91449
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04951
abnormal cerebellar layer morphology	MPO Gene-Phenotype Associations	1.0	null
Connexin, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
PMC7339813-Supplementary_Data2.docx-59-ZBTB46_ZBTB46	Rummagene Transcription Factor Associations 2026	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.73598
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OLN-93 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.206
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67878
NOMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41362
CPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6794
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50637
Constipation	DisGeNET Gene-Phenotype Associations	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
leg muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088019
GTEX-RU72-0826-SM-46MUS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981147
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
X-linked cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
DDX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81994
Lung squamous cell carcinoma_LUSC_TCGA-77-8138-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31483891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14467
MSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18108
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02995
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.5334
SLC4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47843
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61427
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4409
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05296
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.94
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral degeneration	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
BRD-K73681382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28008
Lens fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.266
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
DMD	Pathway Commons Protein-Protein Interactions	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19009
LETM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03235
Barrett Esophagus	DisGeNET Gene-Disease Associations	1.0	null
PMC4923112__F3	PFOCR Pathway Figure Associations 2023	1.0	null
TTC38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46131
generalized abnormality of skin	HPO Gene-Disease Associations	1.0	null
PMC3117129-mp2010119x5.xls-CRS_Amg-Unnamed_5_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
optic atrophy	HPO Gene-Disease Associations	1.0	null
Lymphatic endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.857
Membrane Trafficking	Reactome Pathways 2014	1.0	null
BRD-K23342427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27759
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14787
glial	GeneRIF Biological Term Annotations	1.0	null
babinski sign	HPO Gene-Disease Associations	1.0	null
BRD-K39672303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77264
C11orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12955
BRD-K47694606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54632
charcot-marie-tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.874509
Hepatic Cirrhosis_Liver_GSE6764	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.44452
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukodystrophy disease specific cell type	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
SPTAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8119
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
H3K36me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.89802
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90557
abnormality of the head	HPO Gene-Disease Associations	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052062
Rotary Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11277
SENP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0266
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16755
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.64571
GTPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6142
literature	GeneRIF Biological Term Annotations	1.0	null
AP4E1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03263
SPTBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20678
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42388
one	GeneRIF Biological Term Annotations	1.0	null
detrimental	GeneRIF Biological Term Annotations	1.0	null
NEU3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2469
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
VAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07787
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02172
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28269
RIMS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36719
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DV-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUDT15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91859
CYP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15219
kinetic tremor	HPO Gene-Disease Associations	1.0	null
EW16	DepMap CRISPR Gene Dependency	1.0	4.15655
paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.577999
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.92565
Distal Sensory Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
Syndactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54498
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03412
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.4587
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
peripheral axonal degeneration	HPO Gene-Disease Associations	1.0	null
CTCF_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intention tremor	HPO Gene-Disease Associations	1.0	null
huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.409414
PARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58461
Lymph vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.933
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03727
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058482
Hypomyelinating leukodystrophy 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.585
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
oligodendroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.70644
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Canavan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.119
Globoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
LTF	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195513_2_v_1_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Leptomeninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
gigantocellular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08797
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941337
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.2596
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.930414
HCC2279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.651
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17685
HOXB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74055
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060415
Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
Demyelinating polyneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
abnormality of brain morphology	HPO Gene-Disease Associations	1.0	null
BRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89471
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54831
SH3D21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00786
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POU2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24261
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11626
BRD-K44371786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27013
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.827731
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.40997
KDM5B	ENCODE Transcription Factor Targets	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.994449
BRD-K38975326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89789
pantothenate kinase-associated neurodegeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.740705
ZFP36L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28271
Progressive Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01791
abnormality of the bladder	HPO Gene-Disease Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-6837-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65258
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6913
Gap junction trafficking and regulation	Reactome Pathways 2024	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
RGS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71152
Keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2598
BRD-K97128200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08565
Hereditary spastic paraplegia 49	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.7
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EO-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell-cell junction	GO Cellular Component Annotations 2023	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84526
cyclic-nucleotide phosphodiesterase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.913
connexon complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70274
H4C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17355
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18505
Mesenteric vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
DOHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53176
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TIMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45018
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07144
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00119
muscle weakness	HPO Gene-Disease Associations	1.0	null
acetohexamide-1707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32153
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873674
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19255
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.86663
BHMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9015
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56189
relapsing-remitting multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43504
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.50522
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PEG3	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
proximal	GeneRIF Biological Term Annotations	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.890512
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
Motor And Sensory Neuropathy	DisGeNET Gene-Disease Associations	1.0	null
Trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.639
MARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95759
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2543
GTEX-OOBJ-0526-SM-48TDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12981
NSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65129
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17055
BRD-K78596805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43949
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K23427500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38193
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.3487
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.81191
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23589316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1546
BRD-K55164454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39311
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96023
KPNSI9S	CCLE Cell Line Gene CNV Profiles	1.0	1.62071
NLRC4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79675
H3K36me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
Pelizaeus-Merzbacher Disease	DisGeNET Gene-Disease Associations	1.0	null
b16v	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06494
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03251
identification	GeneRIF Biological Term Annotations	1.0	null
normal phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K53050301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18269
RAB33A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29573
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80118
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0709
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
Sympathetic chain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
RAB15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17886
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06314
WHAMM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77615
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dysfunctional	GeneRIF Biological Term Annotations	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79561909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06351
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSN	Pathway Commons Protein-Protein Interactions	1.0	null
Hypesthesia	DisGeNET Gene-Phenotype Associations	1.0	null
PIGO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88012
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF79	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96694
BRD-K73768826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45188
GSE229978_4_v_8_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 77	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.778
chorea	HPO Gene-Disease Associations	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238108
KRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63851
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68823900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40578
C9orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15602
MPLKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94046
GTEX-P44H-0326-SM-2XCES	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12279
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43586
BRD-K14681218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27396
NHP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08869
outer SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.911856
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.88484
cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129443
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.889
HCC2218	CCLE Cell Line Gene CNV Profiles	1.0	2.8287
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61797
SCC4	DepMap CRISPR Gene Dependency	1.0	3.67903
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60665
Parasympathetic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
Bone structure disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36761
RELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74122
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4221
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AICDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88468
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02114
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Balo concentric sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.057
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12609
Hyperreflexia	DisGeNET Gene-Phenotype Associations	1.0	null
ginkgolide A-4002	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MEIS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.70747
BRD-K08300592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50804
MZ in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50466
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21059
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96672
NPIPB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60409
abnormal mononuclear cell morphology	MPO Gene-Phenotype Associations	1.0	null
treatment	GeneRIF Biological Term Annotations	1.0	null
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3135
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 39	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.937
LBH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77006
H3K36me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03386
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24659
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41438
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5071
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058069
BRD-K63616423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10147
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.8979
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838834
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41016
SLAIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69929
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05792
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49477
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966625
THBD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50735
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5822
BRD-K40419401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21739
Muscle Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061009
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.982197
EDEM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36973
SUOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51534
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29709
H3K36me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Hennekam syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
CYP2U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05524
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.90722
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7288-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain atrophy	HPO Gene-Disease Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15479
Brain Lower Grade Glioma_LGG_TCGA-HW-7486-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
motor delay	HPO Gene-Disease Associations	1.0	null
Hypoplasia	DisGeNET Gene-Disease Associations	1.0	null
CYB5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66717
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34862
brain very small	HPO Gene-Disease Associations	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877001
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7095
CDK20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78344
skeletal muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13352
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56918
syndactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.485885
EIF4EBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94687
peripheral axonal neuropathy	HPO Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8668-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSK3B	KEA Substrates of Kinases	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0209
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8719
CRCGN014_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26593
abnormality of the integument	HPO Gene-Disease Associations	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
OCTANOL	DGIdb Drug Targets 2026	1.0	0.630143
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45365
LIMK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97895
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17309
Congenital heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGA	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal cns myelination	HPO Gene-Disease Associations	1.0	null
UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OHPL-2426-SM-48TDN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952902
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
features	GeneRIF Biological Term Annotations	1.0	null
ETS2_KD_GSE62168_259_mouse_mouse trophoblast stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
abnormality of saccadic eye movements	HPO Gene-Disease Associations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31665
Hypertrophy	CTD Gene-Disease Associations	1.0	1.27039
Sarcoma_SARC_TCGA-PT-A8TR-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Noonan syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
establishment of localization	GO Biological Process Annotations 2015	1.0	null
iPS-20b Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.959722
Giant axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.064
PARD6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07619
EGFR_druginhibition_82_GSE27638	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.55349
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12753
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87335
Cerebellar Dysmetria	DisGeNET Gene-Phenotype Associations	1.0	null
KKU100	DepMap CRISPR Gene Dependency	1.0	2.46116
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GT-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pakistani	GeneRIF Biological Term Annotations	1.0	null
ZNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98484
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41802
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34379
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17132
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65250438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32006
BRSK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35871
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040655
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8623
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BNC1_KD_GDS1978_70_mouse_oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.10388
head tremor	HPO Gene-Disease Associations	1.0	null
Hereditary spastic paraplegia 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.139
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12398
USP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33971
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21929
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.21409
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5080-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	0.192278
DUSP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79176
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hereditary spastic paraplegia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.128
OELE	CCLE Cell Line Gene Expression Profiles	1.0	1.75455
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
BATF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24479
SW954	GDSC Cell Line Gene Expression Profiles	-1.0	-1.81179
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16925
BRD-K70093308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24683
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41690760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43353
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2414
facial palsy	HPO Gene-Disease Associations	1.0	null
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04752
TM-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.122
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	291.162
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2282
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32509
LACTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29081
IOMMLEE	CCLE Cell Line Gene Expression Profiles	1.0	1.35873
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.04556
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01199
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QA-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APOA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64776
primary motor cortex (area M1, area 4)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33026
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10241
GTEX-XMK1-2426-SM-4B66I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896421
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0667
ZFP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07033
SRC_activemutant_51_GSE15815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.69346
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057334
Hypomyelinating leukodystrophy 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
GMPPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84273
LMAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57896
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
SRSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47866
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7654-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
non-myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C1orf198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82549
BRD-K75073699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21043
GTEX-XYKS-1626-SM-4BRUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15652
PMC6433273-pone.0214296.s009.xlsx-Table_D-S4_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_24_hours_of_LPS_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
lymphedema	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.44782
PEO4	DepMap CRISPR Gene Dependency	1.0	7.24452
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.504724
BRD-K07035171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76531
phenotypic variability	HPO Gene-Disease Associations	1.0	null
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19116
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10172
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MT-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
H2AC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88283
Hypomyelinating leukodystrophy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.392
PLXNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92823
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05407
PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95573463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47972
GSE221327_8_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27054
Milroy Disease	DisGeNET Gene-Disease Associations	1.0	null
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.7105
BRD-K02691653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36417
TMEM88B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75684
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067409
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333763
Myelin sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.652
PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
H2AB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58716
CALHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10763
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.89604
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848675
Junctional membrane complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6646
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055909
Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPK-2626-SM-2HMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11291
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.406315
abnormal metencephalon morphology	MPO Gene-Phenotype Associations	1.0	null
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52243
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03799
Motor peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.21021
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19687
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01684
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01091
RCC-JF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2944
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81G-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gap junction channel activity	GO Molecular Function Annotations 2015	1.0	null
connexin complex	GO Cellular Component Annotations 2023	1.0	null
HSPA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32633
Syndactyly type 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
UQCRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33537
BRD-K33912919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3282
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Liver Diseases	CTD Gene-Disease Associations	1.0	1.57924
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ABI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34139
Measles Chicago-1_24Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.57359
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14146
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065829
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40195
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.953317
COPD - Chronic obstructive pulmonary disease_Bronchial epithelium_GSE3320	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.50302
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70864
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT-15	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5541
Hyperplasia	CTD Gene-Disease Associations	1.0	1.25214
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.848
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3472
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18534
Perturb_16459_KO_Nf1_SRP155510	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.36637
GIPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77349
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16491
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
aplasia/hypoplasia of the corpus callosum	HPO Gene-Disease Associations	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03579
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20699
JARID2	ChEA Transcription Factor Targets	1.0	null
AGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95729
WARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7417
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.976048
Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0684
GTEX-XQ3S-1026-SM-4BOPJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51267
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AP5S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56059
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830439
abdominal symptom	HPO Gene-Disease Associations	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17736
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.89441
BRD-K42363982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00154
MACIR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32669
TRAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69222
CORT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08633
PCYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41208
CHKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67467
YMB1	CCLE Cell Line Gene CNV Profiles	1.0	2.69429
KPNYN	DepMap CRISPR Gene Dependency	1.0	2.53701
abnormal brain white matter morphology	MGI Mouse Phenotype Associations 2023	1.0	null
MATK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77796
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13835
Demyelinating Motor Neuropathy	DisGeNET Gene-Phenotype Associations	1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CLCA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2554
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38994
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Subthalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
DRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24981
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.892736
Multipotent progenitor cell_Stomach_Human	CellMarker Gene-Cell Type Associations	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.972633
CEP85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35077
THEM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13044
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18304
HCC1897	CCLE Cell Line Gene Expression Profiles	1.0	1.36362
BRD-K44950949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16158
ATP5PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08071
ST13	Pathway Commons Protein-Protein Interactions	1.0	null
unexplained	GeneRIF Biological Term Annotations	1.0	null
abnormal motor learning	MPO Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14182
HEPG2	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.915046
F7	Pathway Commons Protein-Protein Interactions	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC17A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45532
abnormality of nervous system morphology	HPO Gene-Disease Associations	1.0	null
Lichenification	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841664
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
Perturb_7884_KO_DDX39B_SRP278200	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZNF430	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50475
EIF4ENIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40052
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47911
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.244696
BRD-K01772946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86183
axonal	GeneRIF Biological Term Annotations	1.0	null
Abnormal Motor Evoked Potentials	DisGeNET Gene-Phenotype Associations	1.0	null
Charcot-Marie-Tooth disease type X	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.685
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.957164
BRD-K72892670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37707
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053122
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RHOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88876
TMEM160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66574
Medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.288
UMC-11	GDSC Cell Line Gene Expression Profiles	1.0	1.90743
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.894589
PRC1_BMI_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal myelination	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K06537903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10996
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35359
NEUROD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87815
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39898
GOS3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87068
hypoplasia of the corpus callosum	HPO Gene-Disease Associations	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.915074
Hereditary spastic paraplegia 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.773
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCED1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07776
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.959691
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08484
APOA2	Pathway Commons Protein-Protein Interactions	1.0	null
TLCD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18018
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Squamous cell carcinoma_Lung Tissue_GSE1987	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.347901
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68835
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06698
ZNF195	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61667
E2F6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41356
MZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05839
ELK4	ENCODE Transcription Factor Targets	1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93053
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscular hypotonia of the trunk	HPO Gene-Disease Associations	1.0	null
autosomal recessive inheritance	HPO Gene-Disease Associations	1.0	null
Glomerular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
BRD-K79604175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2939
lymphedema, hereditary, ic	OMIM Gene-Disease Associations	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.031
Fibre tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.501
GALNT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8805
Lens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.175
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895429
gap junction channel activity	GO Molecular Function Annotations 2023	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83578
gap junction channel activity	GO Molecular Function Annotations 2025	1.0	null
COLO-684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal head movements	HPO Gene-Disease Associations	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-JARID2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10113
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.41993
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53261
corpus callosum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.86541
Oligodendroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06758
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11208
hearing impairment	HPO Gene-Disease Associations	1.0	null
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053258
MZT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74508
schmidt-lanterman incisure	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.757707
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51682
pelizaeusmerzbacherlike	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Central Nervous System Demyelination	DisGeNET Gene-Disease Associations	1.0	null
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29200961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29858
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4755
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.903648
Brain Lower Grade Glioma_LGG_TCGA-HT-7902-01A-12R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K75135426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71142
PPIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37165
CST3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09855
MRPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5755
hsf1_19179333_rko_colon_carcinoma_lof_human_gpl6244_gse12762	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.001586
hallermann-streiff syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.38036
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72748
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.096
IFNLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61181
feature	GeneRIF Biological Term Annotations	1.0	null
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08221
Cerebellar Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K84769529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35178
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4455
FBXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06321
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1895
thigh	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.135953
Arterial endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.058
node of ranvier	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.620104
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18657
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.345558
BRD-K30933750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05455
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
leukodystrophy	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6286
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.949785
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.750405
Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839336
BRD-K82335556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22372
SNB75	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
BUB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15915
Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4774-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DPCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88457
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.860498
GTEX-P78B-2526-SM-3P5ZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01295
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31242
cell-cell junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.547
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.02107
abnormal eye physiology	HPO Gene-Disease Associations	1.0	null
BRD-K12119989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.928
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0006
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0549
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
cell-cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853107
Fetal Kidney	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.23845
Lymphedema	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34647
BASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21712
SLR23	CCLE Cell Line Gene Expression Profiles	1.0	2.02627
CRCGN012_HEPG2_24H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0911
Noonan syndrome with multiple lentigines 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.778
PU.1-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
brain	GeneRIF Biological Term Annotations	1.0	null
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.309986
C19orf84	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00858
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858696
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2731
SELENOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8657
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	0.835366
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34631
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Venous endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.5
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S341-1026-SM-4AD71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952423
abnormality of limbs	HPO Gene-Disease Associations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18912
SRSF4_02_154	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61298
PIGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71601
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
wide pore channel activity	GO Molecular Function Annotations 2015	1.0	null
disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.39126
ACSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.096
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076629
FANCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59459
ALB	Pathway Commons Protein-Protein Interactions	1.0	null
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14569
NCIH226	CCLE Cell Line Gene CNV Profiles	-1.0	-2.35559
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05131
Axon cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.364
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
variation	GeneRIF Biological Term Annotations	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.837516
GSTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.4829
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85349
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14638
BOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84631
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89397494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36943
abnormal purkinje cell morphology	MPO Gene-Phenotype Associations	1.0	null
AHSG	Pathway Commons Protein-Protein Interactions	1.0	null
Oligodendroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.789
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	2.62744
ITPRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75873
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05406
Hereditary spastic paraplegia 5A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.727
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51291
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal immune system cell morphology	MPO Gene-Phenotype Associations	1.0	null
Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
Mesaxon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.704
Perivascular astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.366
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.275
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30545
SLC35F6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10008
Ca<sup>2+</sup>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myosin X complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	2.58037
BRD-K20560768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39194
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67181
hypertonia	HPO Gene-Disease Associations	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49439
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866439
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34047
abnormal motor capabilities/coordination/movement	MPO Gene-Phenotype Associations	1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75195
MSANTD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83297
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.796
ZNF211	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38604
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3556
Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MLXIPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.70456
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7CZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
APOA4	Pathway Commons Protein-Protein Interactions	1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
SNU520	CCLE Cell Line Gene Expression Profiles	1.0	1.38506
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14308
wide pore channel activity	GO Molecular Function Annotations 2023	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	204.248
PC3	CCLE Cell Line Gene CNV Profiles	1.0	1.67106
previously	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865061
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.89625
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29414
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterus-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	0.575147
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.114577
region	GeneRIF Biological Term Annotations	1.0	null
BRD-K81779733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45648
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826123
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.367
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
families	GeneRIF Biological Term Annotations	1.0	null
BRD-K46348476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10093
Thalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09731
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00477
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cerebral white matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.621
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49658
SEC61A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81406
NRROS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64087
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04415
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972243
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24114
Cerebral degeneration	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
AMO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.0707
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15758
Superior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
BRD-K31758107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12763
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UMUC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66491
C1orf56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67029
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
CSDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57874
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975868
BICR10	DepMap CRISPR Gene Dependency	1.0	2.54716
Sarcoma_SARC_TCGA-DX-A6YS-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.251
Congenital chylothorax	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
Congenital nystagmus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
oncostatin-M receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.99855
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841539
Hereditary spastic paraplegia 78	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
hsa-miR-3150b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ZNF722	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77897
MAP3K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04707
ARMC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98147
NHLRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55686
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01463
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1065
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
even	GeneRIF Biological Term Annotations	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	197.581
CA2+	DGIdb Drug Targets 2026	1.0	0.322756
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25844701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11642
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46813
PMM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32597
VTI1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83595
channel	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57389
MORC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65572
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54705
Contracture	DisGeNET Gene-Disease Associations	1.0	null
Corticospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.809
Rectum adenocarcinoma_READ_TCGA-G5-6572-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49265
GTEX-TML8-1426-SM-4DXUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10318
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05931
LDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52993
comparable	GeneRIF Biological Term Annotations	1.0	null
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27646
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35032
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.863053
ASCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43215
Spastic paraplegia 44, autosomal recessive	ClinVar Gene-Phenotype Associations	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19335
ZNF385C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67873
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.983
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.937969
OR8D2	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KK-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05036
better	GeneRIF Biological Term Annotations	1.0	null
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16784
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
TUT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15192
Telangiectasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
NCI-H1048	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4685-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44834
functional abnormality of the inner ear	HPO Gene-Disease Associations	1.0	null
gap junction channel activity involved in cell communication by electrical coupling	GO Molecular Function Annotations 2025	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6843
Lung adenocarcinoma_LUAD_TCGA-44-3396-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell-cell junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.23088
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UACC-812	GDSC Cell Line Gene Expression Profiles	1.0	1.4691
abnormality of the middle ear	HPO Gene-Disease Associations	1.0	null
RAD23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63294
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22599787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27523
evaluated	GeneRIF Biological Term Annotations	1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
single-organism localization	GO Biological Process Annotations 2015	1.0	null
abnormality of the genitourinary system	HPO Gene-Disease Associations	1.0	null
BRD-K08142337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23795
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41091
PCDHB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55891
BRD-K32434600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30566
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26559
abnormality of the cerebellum	HPO Gene-Disease Associations	1.0	null
HERC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52187
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal brain white matter morphology	MPO Gene-Phenotype Associations	1.0	null
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42448
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11497
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06245
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17958
Trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
SIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40425
ASCL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03841
SYNGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28487
Erysipelas	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.968838
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964774
HCC2814	CCLE Cell Line Gene CNV Profiles	1.0	2.0438
JPH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40401
hypotrichosis-lymphedema-telangiectasia-renal defect syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22459
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72726
amygdaloid complex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.985321
gap	GeneRIF Biological Term Annotations	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52287
Calcium regulation in cardiac cells	WikiPathways Pathways 2024	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.88842
BRD-K22193148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24548
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.81001
cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.891308
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Juxtaparanode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.947
hsa-miR-4756-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BNC1_KD_GDS1978_738_mouse_Oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XPVG-1426-SM-4B668	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94482
PSME3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06903
Hereditary X-Linked Recessive Spastic Paraplegia	DisGeNET Gene-Disease Associations	1.0	null
abnormal cerebellum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.980475
paraparesis	HPO Gene-Disease Associations	1.0	null
Motor cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37735
PANC1	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
GTEX-QMRM-0926-SM-447BR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913295
APBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75134
CTCF	ENCODE Transcription Factor Targets	1.0	null
el2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.276
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94413
BRD-K47370004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07361
UROD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66679
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6526
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22247
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.258
Perturb_17917_KO_Shank2_SRP314506	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.05837
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.65971
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19041
COQ8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42339
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21663
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95865
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.748753
Gap junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.015
BRD-K77518191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20498
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9781
POLRMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94631
skeletal muscle cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26904
microgliosis	MGI Mouse Phenotype Associations 2023	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GFAP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14383477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15251
PMC4923112__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphedema, hereditary, ic	ClinVar Gene-Phenotype Associations	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055985
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K20799008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.71635
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3431-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCEAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58548
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZC3H12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26965
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40851366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64424
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55012
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.97254
CLPP_KO_GDS4791_543_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K90887068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60009
cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174784
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88293
PLEKHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64746
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.48897
pmldlinked	GeneRIF Biological Term Annotations	1.0	null
novobiocin-4392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
uterus	GTEx Tissue Gene Expression Profiles	1.0	1.00993
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
patient	GeneRIF Biological Term Annotations	1.0	null
PDZRN4	Pathway Commons Protein-Protein Interactions	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0047
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80749
SCYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03484
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15006
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
abnormality of forebrain morphology	HPO Gene-Disease Associations	1.0	null
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
JM1	CCLE Cell Line Gene CNV Profiles	1.0	1.41758
PU.1-20176806-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
evidence	GeneRIF Biological Term Annotations	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Charcot-Marie-Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.52
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.7848
lymph vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.625869
ZC3HAV1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3532
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MRPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31177
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047916
CLPP_KO_GDS4791_108_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
nystagmus	HPO Gene-Disease Associations	1.0	null
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45969
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5132
gap junction	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0692
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KCNMA1	Pathway Commons Protein-Protein Interactions	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881583
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.875738
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34117117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48511
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62708
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
SCMH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22278
FMNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33753
sarcoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
astroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101647
family	GeneRIF Biological Term Annotations	1.0	null
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979897
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49799
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WF-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11183
GM1 gangliosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
JHOS4	DepMap CRISPR Gene Dependency	1.0	2.53767
BRD-K43418395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15904
G124	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
Clumsiness - Motor Delay	DisGeNET Gene-Disease Associations	1.0	null
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16604
BRD-K87516578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01494
RBAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67965
Lung adenocarcinoma_LUAD_TCGA-50-6595-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75035
PMEPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66341
UCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92284
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.195
RNF112	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23301
DACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25179
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15089
MHH-ES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.51155
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52886
BRD-K55642725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58096
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98542
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307889
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
Lung squamous cell carcinoma_LUSC_TCGA-60-2715-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
RARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0512
SFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4167
SLC39A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40268
Leukoencephalopathy with vanishing white matter 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GTEX-WFON-1226-SM-3TW8F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876412
octanol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
pelizaeus-merzbacher disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	2.14481
BRD-K13782363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25964
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12237
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03709
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00318
ROS50	DepMap CRISPR Gene Dependency	1.0	2.77524
cell-cell junction	GO Cellular Component Annotations 2025	1.0	null
Optic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.856
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12833
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86385
Action Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2218	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	66.173
abnormal myeloid leukocyte morphology	MPO Gene-Phenotype Associations	1.0	null
JMJD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43338
Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19514
SW403	DepMap CRISPR Gene Dependency	1.0	9.06239
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50647
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HMBOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25883
Lung adenocarcinoma_LUAD_TCGA-55-6981-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052249
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
ZNF329	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17551
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.652
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MF-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92291
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53828
RPUSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34398
THP1	CCLE Cell Line Gene CNV Profiles	1.0	1.8873
FBXL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04517
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Axon hillock	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
peripheral neuropathy	HPO Gene-Disease Associations	1.0	null
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74267
nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
correlates	GeneRIF Biological Term Annotations	1.0	null
SMIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67912
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Brain endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.464
UNC119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05018
BRD-K22246901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3928
Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6236
demyelinating motor neuropathy	HPO Gene-Disease Associations	1.0	null
CYBRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58902
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04796
BRD-K03070790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20633
abnormal peripheral nervous system morphology	HPO Gene-Disease Associations	1.0	null
THRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72324
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50271
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.9288
NCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08643
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.51495
cx47	GeneRIF Biological Term Annotations	1.0	null
PCDHB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08163
SMARCA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76496
BGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82234
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE218580_1_v_3_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.216332
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MT-ND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7337
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.913
LP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62118
Globoid cell leukodystrophy disease specific cell type	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10933
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lung_4d	HPA Tissue Sample Gene Expression Profiles	1.0	0.899401
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04651
REP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55643
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.937811
Spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.506
HDAC2	ENCODE Transcription Factor Targets	1.0	null
MDA-MB-453	COSMIC Cell Line Gene Mutation Profiles	1.0	null
stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.424963
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11299
HEY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26964
chondrosarcoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89137
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02915
cell part	GO Cellular Component Annotations 2015	1.0	null
FAM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0341
Prestwick-675-2187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897703
Calcium Regulation in the Cardiac Cell(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.215063
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45775
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.31063
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041125
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054552
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80617
H3K36me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38725
brain disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.954119
non-myelinating schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.820666
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.888
Necrosis	CTD Gene-Disease Associations	1.0	1.32905
EDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39992
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K36me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cell junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.4
BRD-K99727034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30596
BRD-K33505770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66129
INPPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6858
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36233
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.897873
RNF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69054
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23852
BRD-K07020302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60319
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26026
BRD-K47599661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23538
Twist2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8526
leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.61933
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0326-SM-4DM6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25653
BRD-K91297952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12914
H3K36me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCLRE1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80273
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09456
report	GeneRIF Biological Term Annotations	1.0	null
SEC14L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69977
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07866
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68098
seen	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68525
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65264
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24532
NELFE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72539
BRD-K94876980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05534
BRD-K54752947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09622
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal axial skeleton morphology	HPO Gene-Disease Associations	1.0	null
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	3.10927
PLEKHF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87806
Hereditary spastic paraplegia 75	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.127
abnormality of the corpus callosum	HPO Gene-Disease Associations	1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.09052
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949576
GTEX-OIZG-0926-SM-3LK5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34222
Gross Motor Development Delay	DisGeNET Gene-Disease Associations	1.0	null
DU4475	CCLE Cell Line Gene Expression Profiles	1.0	1.58191
GTEX-XAJ8-0326-SM-47JYI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868768
GRAP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04704273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39341
MAMLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15221
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00456
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.2
incomplete penetrance	HPO Gene-Disease Associations	1.0	null
abnormality of the urinary system	HPO Gene-Disease Associations	1.0	null
CFB	Pathway Commons Protein-Protein Interactions	1.0	null
Hypomyelinating leukodystrophy 24	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
SKBR3	DepMap CRISPR Gene Dependency	1.0	3.39556
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6075
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.975
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C1-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04291521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02515
DPYSL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33538
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1621
YY1	ENCODE Transcription Factor Targets	1.0	null
BRD-K22854578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0641
abnormality of limb bone	HPO Gene-Disease Associations	1.0	null
TTPAL	Pathway Commons Protein-Protein Interactions	1.0	null
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7299
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05706
Hereditary spastic paraplegia 43	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0515
Talus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42376
Perturb_700_KO_INTS6_SRP299234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.76407
hsa-miR-4505	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
EXOC6	Pathway Commons Protein-Protein Interactions	1.0	null
DUSP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57228
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78725
RAD54B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39053
KCNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92667
Lung squamous cell carcinoma_LUSC_TCGA-22-4593-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
BRD-K58863944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42376
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02168
Cataract 14 multiple types	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
abnormality of skin physiology	HPO Gene-Disease Associations	1.0	null
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.19195
SLC25A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58921
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
ZNF589	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
PAX2	JASPAR Predicted Transcription Factor Targets	1.0	null
rotary nystagmus	HPO Gene-Disease Associations	1.0	null
PMC10806738-mmc2.xlsx-Table_S1-Table_S1_Table_of_significantly_adjusted_p-valued_0_05_up-regulated_genes_log2FC_1_in_MAX-R60Q_transfected_HEK293_cells_relative_to_MAX-WT_transfected_cells_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
METTL21EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6985
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929068
CRCGN014_HEPG2_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1156
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.969171
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fluoxetine-2453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06168
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.11763
ZNF639	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01076
TE6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72765
F2	Pathway Commons Protein-Protein Interactions	1.0	null
ZIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44636
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53326
LRRC37B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34137
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.01061
MZT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38439
effect	GeneRIF Biological Term Annotations	1.0	null
FNBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55131
sclc21h	HPA Cell Line Gene Expression Profiles	1.0	1.33555
cartilage	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased oligodendrocyte number	MGI Mouse Phenotype Associations 2023	1.0	null
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.459
Skeletal muscle cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
lymphoedema	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01556
GTEX-XUZC-0526-SM-4BOPF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968258
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54855
Huntington Disease	DisGeNET Gene-Disease Associations	1.0	null
THY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06086
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49371
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6122
zona incerta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.894745
FAM221A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7878
optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.45447
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36433
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ataxia	HPO Gene-Disease Associations	1.0	null
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
FAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97908
peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.795411
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05904
abnormality of nervous system physiology	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5119-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74403
Keratitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
ZFP90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5192
Axonal neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
NOCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07674
TCF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74304
LYMPHEDEMA, HEREDITARY, IC	CTD Gene-Disease Associations	1.0	2.88009
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28326
abnormality of the cranial nerves	HPO Gene-Disease Associations	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S1PR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35939
RBPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73445
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21351
cc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.518
Venous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
ML-2	GDSC Cell Line Gene Expression Profiles	1.0	1.59411
Lung adenocarcinoma_LUAD_TCGA-50-5935-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8155
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34728
BRD-K60531990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84171
CNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77791
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-02A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
33B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
CERS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20788
GTEX-NPJ7-0011-R2a-SM-2I3GF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24633
TK10	BioGPS Cell Line Gene Expression Profiles	1.0	1.06578
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03516
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mfs6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1054
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55044
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.333
BRD-K14671808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03079
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.611
UBL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5852
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057058
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5594
GSE217363_6_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HSPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32775
furosemide-6841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
single organism signaling	GO Biological Process Annotations 2015	1.0	null
Lymphangitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
consistent	GeneRIF Biological Term Annotations	1.0	null
GRINA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37062
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.969006
MYL4	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20460542-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3935
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12335
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A907-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Noonan syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
Bone cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.69952
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80349
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18657
BRD-K21826560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37392
ATCAY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25933
Fumarase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
BAHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78393
Ventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.08
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Hypomyelinating leukodystrophy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
15326474-Table2a	GeneSigDB Published Gene Signatures	1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
COX5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56579
Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDCA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38089
C19orf44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13757
ACTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23436
WASHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38145
FAM111A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90827
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
merzbacher	GeneRIF Biological Term Annotations	1.0	null
ependymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.178946
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.908711
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070058
adult-onset autosomal dominant demyelinating leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24114
NECTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17569
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.910866
BRD-K11671824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15014
nucleus subceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.83524
TUBB2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88885
astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09208
IGHG2	Pathway Commons Protein-Protein Interactions	1.0	null
HMGCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90213
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929617
Prostate adenocarcinoma_PRAD_TCGA-G9-6365-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SERTAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74484
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.86348
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923114
lower limb spasticity	HPO Gene-Disease Associations	1.0	null
clinical	GeneRIF Biological Term Annotations	1.0	null
BRD-K16717067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29393
H3K36me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Decreased Motor Nerve Conduction Velocity	DisGeNET Gene-Phenotype Associations	1.0	null
connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5199-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062516
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47267
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89741
Hereditary spastic paraplegia 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.448
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59497
Maternal Uniparental Disomy Of Chromosome 1	DisGeNET Gene-Disease Associations	1.0	null
lymphedema	GeneRIF Biological Term Annotations	1.0	null
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.130752
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928894
Lichenification And Lichen Simplex Chronicus	DisGeNET Gene-Phenotype Associations	1.0	null
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ITGB1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99918
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43353
S100A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51074
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal myelination	MPO Gene-Phenotype Associations	1.0	null
H3118	DepMap CRISPR Gene Dependency	1.0	2.89234
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093317
Talipes	DisGeNET Gene-Disease Associations	1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2884
PWWP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62611
RERF-LC-MS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.95997
Connexin, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
GTF2IRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32551
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19889
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
overall	GeneRIF Biological Term Annotations	1.0	null
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
frequencies	GeneRIF Biological Term Annotations	1.0	null
BRD-K34720817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23674
phenotype	GeneRIF Biological Term Annotations	1.0	null
CAMTA1	Pathway Commons Protein-Protein Interactions	1.0	null
SLC8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5781
ZNF638	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55007
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41592
autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051249
Central conducting lymphatic anomaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nystagmus	GeneRIF Biological Term Annotations	1.0	null
action tremor	HPO Gene-Disease Associations	1.0	null
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.1284
SW1271	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34988
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
appreciated	GeneRIF Biological Term Annotations	1.0	null
Hereditary spastic paraplegia 70	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48837
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5489
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB13	DepMap CRISPR Gene Dependency	1.0	5.63249
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE81193_3_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43778
PARL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64439
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	2.68034
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22908
GTEX-UPK5-1326-SM-4IHLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16935
abnormality of peripheral nervous system electrophysiology	HPO Gene-Disease Associations	1.0	null
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.245396
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
miconazole-6615	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.45818
TAPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31524
BRD-K04785821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1263
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073694
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50389
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
ZNF385A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74204
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07844
PTPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04314
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30083
GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62708
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67547
GTEX-T2IS-0926-SM-4DM5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1054
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TLX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3739
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.84366
HOXD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95467
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.838412
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44323
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.99361
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00350773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46562
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05503
TRAPPC11	Pathway Commons Protein-Protein Interactions	1.0	null
syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.088484
Plasma membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K33462260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52696
Venous endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Niemann-Pick disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hypomyelinating leukodystrophy	ClinVar Gene-Phenotype Associations 2025	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070283
FEZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52078
SCA1_Knock-in_GDS1756_232_mouse_Cerebellum tissue - 12 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
LIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8098
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39093
SLR24	CCLE Cell Line Gene Expression Profiles	1.0	1.9471
ZNF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96848
FBXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98298
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05351
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.875998
Muscular Hypotonia Of The Trunk	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.05794
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1539
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84608
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50462
GNG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64333
BRD-K04092807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58315
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02684
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06867
neurodegeneration	MPO Gene-Phenotype Associations	1.0	null
BRD-K36347292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87161
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39695412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04118
included	GeneRIF Biological Term Annotations	1.0	null
ZDHHC22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65323
FAM168A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79749
HCST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16578
SGOL2	Pathway Commons Protein-Protein Interactions	1.0	null
DEGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16841
FARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87493
TTC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89846
GPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46736
CRCGN015_MCF10A_48H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18582
Sarcoma_SARC_TCGA-MO-A47R-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
Penis_Foreskin_Keratinocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.08093
HDAC6	ENCODE Transcription Factor Targets	1.0	null
abnormality of peripheral nerves	HPO Gene-Disease Associations	1.0	null
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59497
Cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.1
ZNF454	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22296
FOSL2	ENCODE Transcription Factor Targets	1.0	null
BRD-K37386363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46537
CVB3_9Hour-Infection_None_GSE697	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52448
GJA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34398
CEP76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53425
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55629
GSE133213_6_v_1_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
ITIH1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8312-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACAD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3749
HP	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56024445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12298
cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.338914
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4317_KO_Fmn2_SRP109283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.21277
primary motor cortex (area M1, area 4)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.956209
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12039
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	3.96832
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41015
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF493	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25557
abnormal muscle tone	HPO Gene-Disease Associations	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49474
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79176
CARBENOXOLONE	DGIdb Drug Targets 2026	1.0	0.508961
Medial longitudinal fasciculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
beta-N-acetylhexosaminidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.446
PAX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39549
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22136
BRD-K06459664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19773
OVOL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08697
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ET-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hindgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.181054
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78718
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.871353
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Paraparesis, Spastic	DisGeNET Gene-Phenotype Associations	1.0	null
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.319
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.85381
leukodystrophy	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1556
HDAC1	ENCODE Transcription Factor Targets	1.0	null
Idiopathic scoliosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
cell-cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MTFMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06997
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25039453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92335
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5126
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.50343
CPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00659
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC827GR5	CCLE Cell Line Gene Expression Profiles	1.0	1.73875
H3K36me3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.922293
CCDC160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30343
MAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38198
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15737
aplasia/hypoplasia of the cerebrum	HPO Gene-Disease Associations	1.0	null
Motor Delay	DisGeNET Gene-Phenotype Associations	1.0	null
Fucosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Polyneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
DCAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79058
GTEX-Q734-1426-SM-48TZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907296
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.331
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.90123
distal sensory impairment	HPO Gene-Disease Associations	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30893
Gap junction trafficking and regulation	Reactome Pathways 2014	1.0	null
Macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.589
Oligodendrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.787
Lung squamous cell carcinoma_LUSC_TCGA-21-5787-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44236678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39259
SMIM10L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83186
lung_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.854433
GSE229978_4_v_2_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842889
BRD-K18296568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13711
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.934102
promoter	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16629
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43462
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09292
MHHES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58243
GTEX-UJHI-0926-SM-4IHKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991952
hsa-miR-3187-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Familial Multiple Trichoepitheliomata	DisGeNET Gene-Disease Associations	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CAL148	CCLE Cell Line Gene CNV Profiles	1.0	1.63016
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40918
BRD-K44445002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02006
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF700	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12127
following	GeneRIF Biological Term Annotations	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
PMC8454054-13059_2021_2489_MOESM17_ESM.txt--SOX10_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
B4GALT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68642
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90459
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11022
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57716
NCIH1299	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34263
hsa-miR-4758-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
HEMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19595
cerebral atrophy	HPO Gene-Disease Associations	1.0	null
SDF2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87546
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54003
ZNF527	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54992
localization	GO Biological Process Annotations 2015	1.0	null
Hereditary sensory neuropathy type 2C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
BRD-K96968070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09246
PLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7881
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15965
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94505
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27176
Hyperkeratosis	DisGeNET Gene-Disease Associations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7269
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956025
Siphon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
GPATCH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32921
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940962
BRD-K57271749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16087
SP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1103
Myelin membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.678
GTEX-NPJ7-1726-SM-2YUNA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844257
TSPYL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59389
gap junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.67933
SETX	Pathway Commons Protein-Protein Interactions	1.0	null
PCBP2_02_135	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.05889
BRD-K04399953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04417
RAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.52244
TARBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77044
Rectum adenocarcinoma_READ_TCGA-F5-6863-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.56896
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16494
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23396
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842868
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.24753
cell junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.11123
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86313
Brain Lower Grade Glioma_LGG_TCGA-HT-7620-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
Neurilemoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6369
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.379
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01199
ANAPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03596
KP-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.68926
PDCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30067
CREM	ChEA Transcription Factor Targets	1.0	null
Amoeboid microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
MERO48A	DepMap CRISPR Gene Dependency	1.0	2.48499
FAM131A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47949
Aiolos_NULL MUTATION_GDS3473_572_mouse_Bone marrow pre-BII cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924706
Acute Myeloid Leukemia_LAML_TCGA-AB-2915-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859616
NB7	DepMap CRISPR Gene Dependency	1.0	9.01878
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06226
PTEN_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.891
Bicellular tight junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.264
Thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.596
MEST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44312
Mesentery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.1
CYP2R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29977
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922762
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59237
KRT13	Pathway Commons Protein-Protein Interactions	1.0	null
CX-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.589
KIAA1551	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13568
Lung squamous cell carcinoma_LUSC_TCGA-52-7809-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.881
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02562
decreased nerve conduction velocity	HPO Gene-Disease Associations	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.841298
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.982622
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
NCIH1693	DepMap CRISPR Gene Dependency	1.0	2.43232
TRIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05181
HCC2157	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34484
Agenesis	DisGeNET Gene-Disease Associations	1.0	null
Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
brain	HPA Tissue Gene Expression Profiles	1.0	1.98538
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50355
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.11912
MAP4K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58107
B4GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67524
Inflammation	CTD Gene-Disease Associations	1.0	1.51004
BRD-K62650632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19741
PLEKHH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1786
BRD-K00767817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3338
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01531
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X5-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87926172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28274
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
HEY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77044
MED15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7141
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.15399
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05135
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NS-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04336022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58646
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65627
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.187
PAPSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0682
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.02448
PAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28707
Hereditary lymphedema IC	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.3
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85133
RNF2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47717
membrane part	GO Cellular Component Annotations 2015	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.114
SF767	CCLE Cell Line Gene Expression Profiles	1.0	1.36509
CLPP_KO_GSE40207_394_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Neuroma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10307
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
lymphatic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.65543
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040892
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.26624
MZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09669
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97628
BRD-K08702524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67742
known	GeneRIF Biological Term Annotations	1.0	null
BRD-K25974714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10362
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.847551
BRD-K52582315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08114
PMC4595011-pgen.1005555.s003.xlsx-MITF_UP-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukodystrophy	DisGeNET Gene-Disease Associations	1.0	null
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ANKRD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57371
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.25898
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
CRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51607
showed	GeneRIF Biological Term Annotations	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	231.473
Lung squamous cell carcinoma_LUSC_TCGA-22-5472-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.868175
CD63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42383
abnormal oligodendrocyte physiology	MPO Gene-Phenotype Associations	1.0	null
Intention Tremor	DisGeNET Gene-Phenotype Associations	1.0	null
SCN5A	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3162-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ST8SIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43885
Perturb_15189_KD_TP63_SRP056637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
WTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.51871
TMEM50A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14279
BRD-K13425292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18601
Abnormality of the nervous system	ClinVar Gene-Phenotype Associations 2025	1.0	null
CTB-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42603
should	GeneRIF Biological Term Annotations	1.0	null
OR2T6	Pathway Commons Protein-Protein Interactions	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052345
Gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22726
gap junction channel activity involved in cell communication by electrical coupling	GO Molecular Function Annotations 2023	1.0	null
GSE217363_0_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04173
LRRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89738
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308612
signs	GeneRIF Biological Term Annotations	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.78407
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-591-ZNF774_ZNF774	Rummagene Transcription Factor Associations 2026	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24352
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
coupling	GeneRIF Biological Term Annotations	1.0	null
CHD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41985
BRD-K66605600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09464
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.274394
Adductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
astrocytosis	MGI Mouse Phenotype Associations 2023	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.68235
KMS21BM	CCLE Cell Line Gene CNV Profiles	1.0	1.50173
EZH2-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K09137343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38763
Secondary progressive multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DPY-21335234-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8192
mode of inheritance	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
PMC7445411-CPR-53-e12862-s006.xlsx-Sheet1-Supplementary_Table_S4_Gene_expression_profiling_of_NT-MSC_and_III-MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
EVPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15378
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00596
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.45357
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832551
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.02299
abnormal phagocyte morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.903502
TIMM17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88712
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypomyelinating	GeneRIF Biological Term Annotations	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.81594
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18895
immune system phenotype	MPO Gene-Phenotype Associations	1.0	null
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.73993
496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22265
axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.320451
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8187-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLPP_KO_GSE40207_397_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.38341
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34595616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37543
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00028
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29253
BRD-K67183010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22219
NEXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47274
C5orf34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39426
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TMCO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46299
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.97332
Clouston syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.857
abnormality of the seventh cranial nerve	HPO Gene-Disease Associations	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
GTEX-TKQ2-0926-SM-4DXU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40554
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831535
ZNF410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14693
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956229
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11287
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EI-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3955
evaluation	GeneRIF Biological Term Annotations	1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0416
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the fundus	HPO Gene-Disease Associations	1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	5.26537
mutants	GeneRIF Biological Term Annotations	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45322
JAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02177
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
DNMBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55665
GSE213219_0_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.45
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47932
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21814
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62492
BRD-K98891210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2574
BRD-K44622259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18324
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
abnormality of the eye	HPO Gene-Disease Associations	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963438
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2
AMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37957
like	GeneRIF Biological Term Annotations	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86891
BRD-K35826866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93995
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61568
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75102
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.15581
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73028
SSBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88456
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040929
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
BRD-K08262651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08125
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-0.891926
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71257
pes cavus	HPO Gene-Disease Associations	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03171
BZW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67921
cochlear duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.394197
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875358
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.662
only	GeneRIF Biological Term Annotations	1.0	null
ZNF417	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94846
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91541
ZFP69B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25935
no abnormal phenotype detected	MPO Gene-Phenotype Associations	1.0	null
NB13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42986
EZH2	ChEA Transcription Factor Targets	1.0	null
Perturb_14988_KO_Phf8_SRP093797	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.29025
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869619
seizures	HPO Gene-Disease Associations	1.0	null
dysmetria	HPO Gene-Disease Associations	1.0	null
NCOA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07577
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16034
plhc-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213291
BRD-K85972696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66704
female	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.274394
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.107
Purkinje cell degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
MDFI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01168
Anterior commissure	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.24
ZNF496	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77624
Multiple Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
Hyperkeratosis	DisGeNET Gene-Phenotype Associations	1.0	null
Inferior olivary nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.218
modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.342233
Dysmorphic Features	DisGeNET Gene-Disease Associations	1.0	null
BRD-K25877330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28899
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75498
SMC3-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Primary autosomal recessive microcephaly 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
Lung squamous cell carcinoma_LUSC_TCGA-60-2716-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3743
Hereditary spastic paraplegia 37	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
KP2	DepMap CRISPR Gene Dependency	1.0	2.51062
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SU8686	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77214
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19792
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267446
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00335
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87252
KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PHC3	Pathway Commons Protein-Protein Interactions	1.0	null
involuntary movements	HPO Gene-Disease Associations	1.0	null
abnormal brain morphology	MPO Gene-Phenotype Associations	1.0	null
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82568
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BC-3	GDSC Cell Line Gene Expression Profiles	1.0	1.6152
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2334
Learning Disorders	CTD Gene-Disease Associations	1.0	1.65511
TAF1	ENCODE Transcription Factor Targets	1.0	null
Hypomyelinating leukodystrophy 2	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876816
gap junction	GO Cellular Component Annotations 2025	1.0	null
TCF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46843
Abnormal Visual Evoked Potential	DisGeNET Gene-Phenotype Associations	1.0	null
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Parkinsonism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
CHPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76109
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4706-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ciliary pocket collar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mild	GeneRIF Biological Term Annotations	1.0	null
Lymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.704
BRD-K18084996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35694
NFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63357
DICER1_KO_GDS4504_584_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K12271646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08281
oligodendroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.81983
FAM193A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1702
ANTXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21695
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20984
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965761
BRD-K04680784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00369
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059699
HCC202	DepMap CRISPR Gene Dependency	1.0	2.37216
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.81196
NCIH1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65522
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53928
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.970146
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GOLGA8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27963
LRRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67598
astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07839
ZNF783	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46874
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16952
Noonan syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
abnormality of the musculature	HPO Gene-Disease Associations	1.0	null
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.65338
ocular motility disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.451454
sciatic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.705173
Lower Limb Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
HSPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75437
Calcium Regulation in the Cardiac Cell(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
H2BK12ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Thymus-endothelial cell of lymphatic vessel	Tabula Sapiens Gene-Cell Associations	1.0	1.14945
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11565
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4906
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_downregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059855
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.331
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.342233
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95178
assembly	GeneRIF Biological Term Annotations	1.0	null
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNMT3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80589
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11057086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26993
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.281
TTC9C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25972
Corneal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
HUPT4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48965
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Congenital Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
PRC_Partial Depletion_GDS3531_563_human_U2OS cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XOT4-0826-SM-4B66Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826085
ADPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68432
RCOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84112
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	2.37493
Hypomyelinating leukodystrophy 21	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.739
Lymphatic Malformation	DisGeNET Gene-Disease Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WQ-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the vertebral column	HPO Gene-Disease Associations	1.0	null
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37915
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14486
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inferior olivary complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
BRD-K24124047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20088
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
BRD-K33960497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16795
leukodystrophy	HPO Gene-Disease Associations	1.0	null
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.893376
BRD-K24711162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09301
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-1826-SM-4IHKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10572
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59499
GTEX-Q734-0826-SM-48U1G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08634
spasticity	HPO Gene-Disease Associations	1.0	null
KYSE150	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41728
Tanycyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SLC29A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52274
Prostate adenocarcinoma_PRAD_TCGA-G9-6356-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33268483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30751
NCIH1436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81622
EMILIN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
abnormality of muscle physiology	HPO Gene-Disease Associations	1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079829
impairment	GeneRIF Biological Term Annotations	1.0	null
UBE3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27857
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40964
tremor by anatomical site	HPO Gene-Disease Associations	1.0	null
Breast Cancer_Mammary Gland Tissue_GSE3744	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.95296
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55425
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
ENC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31087
Paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.021
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.926967
Spastic Paraplegia	DisGeNET Gene-Disease Associations	1.0	null
ANKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55118
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Urinary Incontinence	DisGeNET Gene-Phenotype Associations	1.0	null
TPSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15142
SDCBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11762
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041029
secondary	GeneRIF Biological Term Annotations	1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	156.992
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85357
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043329
Anterior cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
u2197	HPA Cell Line Gene Expression Profiles	1.0	0.939383
macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.41169
SHISA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16347
NFIC	ENCODE Transcription Factor Targets	1.0	null
RIPPLY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06532
BRD-K47309161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2997
Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34645
PRSS3	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.08757
endometrium_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.895002
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88075
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55827
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.287
BRD-K56820801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4505
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39265
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905793
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLC22A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64929
SIVA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29925
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970915
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56077
IGKC	Pathway Commons Protein-Protein Interactions	1.0	null
Great saphenous vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.95
EZH2	ENCODE Transcription Factor Targets	1.0	null
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01695
CABLES1	Pathway Commons Protein-Protein Interactions	1.0	null
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044923
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
dystonia	HPO Gene-Disease Associations	1.0	null
PALB2	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12206
BRD-K34542210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0175
RAB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15397
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.933985
Muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.912425
MAFK	ENCODE Transcription Factor Targets	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LCLC103H	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97315
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948293
HOXB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48168
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01504
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924116
GGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91359
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21724
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
HS936T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70766
carbenoxolone	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932921
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
predicted	GeneRIF Biological Term Annotations	1.0	null
decreased locomotor activity	MGI Mouse Phenotype Associations 2023	1.0	null
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.5
CHRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84434
Connexin	InterPro Predicted Protein Domain Annotations	1.0	null
Neuro-2a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
POLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67247
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34163
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212761
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913645
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
DZIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83222
BRD-K23112275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27901
fallopian tube	GTEx Tissue Gene Expression Profiles	1.0	0.926457
ZNF292	Pathway Commons Protein-Protein Interactions	1.0	null
Vesicle-mediated transport	Reactome Pathways 2024	1.0	null
BRD-K59560948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3364
Muscle Rigidity	DisGeNET Gene-Phenotype Associations	1.0	null
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.3962
BRD-K10781609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09637
HMGN3	ENCODE Transcription Factor Targets	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056241
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypomyelinating leukodystrophy 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.189
PMC6754502-41598_2019_50051_MOESM3_ESM.xlsx-Br_to_Fay_Heat_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EW8	CCLE Cell Line Gene Expression Profiles	1.0	1.45915
TSC22D1	Pathway Commons Protein-Protein Interactions	1.0	null
NPHS1	Pathway Commons Protein-Protein Interactions	1.0	null
Dystrobrevin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.962427
Specific Learning Disability	DisGeNET Gene-Disease Associations	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
CUX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68696
COLO783	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01419
PMC4595011-pgen.1005555.s003.xlsx-MITF_UP-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RHBDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5291
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72399
JHH6	CCLE Cell Line Gene CNV Profiles	1.0	1.48049
TAF7	ENCODE Transcription Factor Targets	1.0	null
odd	GeneRIF Biological Term Annotations	1.0	null
TMEM92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7817
GDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50421
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSK3B	Hub Proteins Protein-Protein Interactions	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ependymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.471
H3K36me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
BRD-K17609687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10993
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50647
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10218
PEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77889
Hallermann-Streiff syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
H3K36me3_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70651
whether	GeneRIF Biological Term Annotations	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095657
Lung-lung microvascular endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.307139
Cerebral cavernous malformation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
Axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.516
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07694
HPX	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89537
USP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71062
abnormality of coordination	HPO Gene-Disease Associations	1.0	null
connexon complex	GO Cellular Component Annotations 2015	1.0	null
MYLK3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13350372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12461
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
GATA1-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
unrelated	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24376
JJ012	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.975204
OR3A2	Pathway Commons Protein-Protein Interactions	1.0	null
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53877
Olfactory ensheathing cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
abnormality of the optic nerve	HPO Gene-Disease Associations	1.0	null
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
PNMA8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84107
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72827
BRD-K45272675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22487
Gap junction assembly	Reactome Pathways 2024	1.0	null
SOX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72425
atrophy/degeneration affecting the cerebrum	HPO Gene-Disease Associations	1.0	null
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.421148
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37017
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.89036
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46227
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.874596
microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.466498
Epidermal nevus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6295
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079075
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64556
Pendular Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4769
Chiasma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
monorden-6178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A76W-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arteriovenous malformation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10153
CEP44	Pathway Commons Protein-Protein Interactions	1.0	null
PPP6R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50781
TRIAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53637
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0666
hsa-miR-4708-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
Adrenoleukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.853
Anterior horn cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
H3K36me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13941052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75538
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3986
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.5366
neuro-2a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.320227
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64431
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051229
hsa-miR-1285	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
496100531_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.6252
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49974
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.836626
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.982468
JHESOAD1	CCLE Cell Line Gene Expression Profiles	1.0	1.55032
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882607
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24747
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30941
cranial nerve paralysis	HPO Gene-Disease Associations	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
BRD-K21933068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17994
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98624
BRD-K21423945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16586
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4153-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF85	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19892
IGHG1	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4598
Chondrosarcoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844836
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
PIK3R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86333
transporter activity	GO Molecular Function Annotations 2015	1.0	null
hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.253908
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240216
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45379
CDYL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38166
TBCEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85879
CCDC66	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03966
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358919
IFI16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87871
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.973197
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69368
bone	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06698
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26503
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.963458
NKX2-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15422
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974445
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04943
CELSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58066
GTEX-T6MN-1526-SM-4DM5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99127
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.6387
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47042
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839336
MZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99897
C10orf82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82599
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07252
TTN	Pathway Commons Protein-Protein Interactions	1.0	null
SDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42023
single-organism process	GO Biological Process Annotations 2015	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.777
Charcot-Marie-Tooth disease type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
PPARG	ChEA Transcription Factor Targets	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.34664
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44439
COX5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47355
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94761
BRD-K57938735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3099
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26362
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47M-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.955