association dataset threshold value standardized value BCR Pathway Commons Protein-Protein Interactions 1.0 null EEF1AKMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30515 BRD-K61092554 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02951 GCG Pathway Commons Protein-Protein Interactions 1.0 null CRCGN016_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64132 IRX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88158 SUDHL1 CCLE Cell Line Gene CNV Profiles 1.0 2.48358 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.93502 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.1867 CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3089 intermediate stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 POLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13471 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02244 HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.22584 G Protein Signaling Pathways(Mus musculus) WikiPathways Pathways 2014 1.0 null PMC4259415-oncotarget-05-10198-s002.xlsx-Sheet1-CREB_Pathway_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBE2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39395 BRD-K75325409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07657 CRCGN017_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12017 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27214 chloropyramine-3350 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979711 GSE84148,GSE96938_0_v_2_nrros_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31389 BRD-K28483134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3805 GSE165939_2_v_1_poldip2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC3775648__F3 PFOCR Pathway Figure Associations 2023 1.0 null SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05911 Cerebellar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0085 H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KD DepMap CRISPR Gene Dependency 1.0 2.7114 BRD-K57937572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14314 BRD-K65891102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68903 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48379 GNAT3 Pathway Commons Protein-Protein Interactions 1.0 null Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32648 Perturb_11339_KD_Mll4_SRP241682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.26366 Ovarian surface epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.968 Perturb_14567_KO_Got2_SRP348541 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.323 FZD6 Pathway Commons Protein-Protein Interactions 1.0 null TXK Pathway Commons Protein-Protein Interactions 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7652-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31389 SLC35B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43157 BRD-K14070721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04433 cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null zidovudine-3211 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K62781263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12296 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SP-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99543 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 MAZ ENCODE Transcription Factor Targets 1.0 null PI3K-Akt signaling pathway KEGG Pathways 2026 1.0 null Perturb_3455_KO_Mecp2_SRP017936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.5223 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null OPN5 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_4810_KO_Atp2b4_ERP004375 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.79475 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null DAGLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64452 Gastrin-CREB signalling pathway via PKC and MAPK Reactome Pathways 2014 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28186 SIX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91708 G alpha (i) signalling events Reactome Pathways 2024 1.0 null Perturb_8634_KO_Htr6_SRP223109 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.76268 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Ovarian surface epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.641 BRD-K26765362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07897 ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4344 BRD-K64571715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7852 Perturb_5308_KO_Tet1/Tet2/Tet3_SRP101434 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.80459 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.198 NATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78399 Perturb_10363_KD_Rorc_SRP185851 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.68973 Retrograde endocannabinoid signaling KEGG Pathways 2026 1.0 null RHOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83925 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15629 Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75437 H3K27me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE221327_5_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71899 SNU182 CCLE Cell Line Gene CNV Profiles -1.0 -2.59176 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7605384__F6 PFOCR Pathway Figure Associations 2023 1.0 null III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57091 mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27847 H3K27me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K61551681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.303 TOMM34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7393 molecular_function GO Molecular Function Annotations 2015 1.0 null BRD-K24170552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68224 Perturb_3346_KO_Sox4_SRP094461 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.42708 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06183 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08562 hsa-miR-4494 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34556 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.80177 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919038 ZNF683 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13062 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.894613 EB2 GDSC Cell Line Gene Expression Profiles -1.0 -1.45508 IGKC Pathway Commons Protein-Protein Interactions 1.0 null CD247 Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE123372,GSE123373_10_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ESRRB-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null nefopam-3627 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K13267130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.28582 Perturb_7328_KO_KMT2C_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.67079 Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70229 ZFTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7907 CRCGN015_MCF10A_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.79738 BRD-K56912308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17971 496100459_PCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.28018 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.28434 superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15986 Perturb_15644_KD_Cebpb_SRP160879 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.6424 amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.31037 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.991617 BRD-K86019347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61489 BRD-K82922770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65484 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.937647 CRCGN016_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40383 RTN4R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55911 OPN1LW Pathway Commons Protein-Protein Interactions 1.0 null ZKSCAN3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1476 BRD-K01676126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94173 flucloxacillin-6507 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_17281_KO_Gja1_SRP247546 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.3944 EGR1 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brush cell (Tuft cell)_Lung_Mouse CellMarker Gene-Cell Type Associations 1.0 null SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1944 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16637 ERG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23452 HESX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3511 Perturb_2152_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.77252 ELAVL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97737 UACC257 BioGPS Cell Line Gene Expression Profiles -1.0 -0.945259 WNT16 Pathway Commons Protein-Protein Interactions 1.0 null WM88 DepMap CRISPR Gene Dependency 1.0 2.37749 Seta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.075 RMUGS CCLE Cell Line Gene Expression Profiles 1.0 1.70453 MAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78632 HCC364 CCLE Cell Line Gene CNV Profiles -1.0 -1.50944 (+/-)-catechin-4837 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prestwick-864-4113 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70254692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57536 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGLC2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3379_KO_Pgd_SRP309436 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.7507 Extrinsic component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.92665 TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 168.755 Perturb_6728_KD_VPS4B_SRP187973 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.20677 LIPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85294 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IBA57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38436 macromolecular complex GO Cellular Component Annotations 2015 1.0 null head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.72196 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.51037 BRD-K62584372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24246 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null fenspiride-2269 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC6929403__F2 PFOCR Pathway Figure Associations 2024 1.0 null BRD-K99859971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70138 ESRRB-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.65752 Olfactory epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.754 BRD-K29469525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7494 BOLA2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93282 biperiden-5279 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cytoplasmic side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.099 Small_Intestine-intestinal tuft cell Tabula Sapiens Gene-Cell Associations 1.0 1.65778 EZH2 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.889846 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.19939 regulation of biological process GO Biological Process Annotations 2015 1.0 null Glucagon-type ligand receptors Reactome Pathways 2014 1.0 null flumequine-2276 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MFE-296 GDSC Cell Line Gene Expression Profiles -1.0 -1.42088 biological regulation GO Biological Process Annotations 2015 1.0 null SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25534 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.2042 FGF17 Pathway Commons Protein-Protein Interactions 1.0 null Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6571 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null theobromine-3334 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60178 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68593 UGCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8625 PMC6137108__F3 PFOCR Pathway Figure Associations 2024 1.0 null Declive (VI), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84155 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GNG2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K03935681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51064 NPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31157 anterior olfactory area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33327 DU4475 CCLE Cell Line Gene Expression Profiles 1.0 2.23873 FZD8 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Disease Reactome Pathways 2014 1.0 null G-protein beta/gamma-subunit complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.63 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 Perturb_7757_KD_MPP6_SRP337423 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.9181 primary auditory cortex (core)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.34021 CRCGN014_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1969 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE92457_9_v_10_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_96_KI_KMT2C_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.41623 FEM1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21318 C10orf88 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23445 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2679 BRD-K62942008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16113 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23776 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NPY1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05518 TEAD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8169 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Anterior olfactory nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32334 Perturb_16712_KO_Ppbp_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.4172 Perturb_14050_OE_NFIB_SRP281947 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.94817 MEIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8893 Glutamatergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.562 ZIC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.9819 OLIG2-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_13212_KO_Lima1_ERP128082 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.9819 SNX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49139 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CPTP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60589 BRD-K82082713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17138 RLIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98686 ventrolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1378 GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null sulmazole-4127 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.036 Brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 16-phenyltetranorprostaglandin E2-7541 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null layer 1 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0482 Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.843654 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34399 PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null alpha-yohimbine-2778 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ERBB2_knockdown_232_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.69251 Perturb_13318_KD_Gtf2i_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.35104 CNTRL Pathway Commons Protein-Protein Interactions 1.0 null BRD-K79067166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11041 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null Alpha thalassemia-intellectual disability syndrome type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 A2780 DepMap CRISPR Gene Dependency 1.0 2.04599 CRCGN014_HEPG2_3H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9855 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.715292 PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_H_sapiens_970_TFAP2B Rummagene Transcription Factor Associations 2026 1.0 null CPSF6 Pathway Commons Protein-Protein Interactions 1.0 null Periplasmic side of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.468 cerebellar white matter Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4503 Glucagon signaling in metabolic regulation Reactome Pathways 2014 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Fastigial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10327 MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07013 PANC0213 CCLE Cell Line Gene CNV Profiles -1.0 -1.39896 HUPT4 CCLE Cell Line Gene CNV Profiles -1.0 -1.34824 BRD-K85359206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45621 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_3418_KO_Satb2_SRP256439 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.57487 BRD-K25718133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39602 BRD-K44779670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06836 PPOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65057 BRD-K47415214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5256 GABPA ENCODE Transcription Factor Targets 1.0 null PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.973589 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Taste bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.293 BRD-K23405293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29413 Perturb_5870_KD_Cpsf7_SRP336206 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.78652 POLI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35047 CDCP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31721 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.930445 BRD-K02073410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38392 BRD-K09972656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33535 CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44299 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.747 MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3523 Neostriatal neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 Extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.109 FGF1 Pathway Commons Protein-Protein Interactions 1.0 null Prostacyclin signalling through prostacyclin receptor Reactome Pathways 2014 1.0 null BRD-K96958073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43981 GSE219195_4_v_5_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23367 Olfactory nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.701 Lateral posterior nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56427898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11251 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.911531 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06198 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Perturb_13572_KD_Setdb1_SRP059699 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.92267 CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63375 BRD-K47966145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89434 GSE210101,GSE210114_6_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null ADP signalling through P2Y purinoceptor 1 Reactome Pathways 2014 1.0 null FGFR3 Pathway Commons Protein-Protein Interactions 1.0 null abnormal rod electrophysiology MGI Mouse Phenotype Associations 2023 1.0 null BRD-K46001734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20441 cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.058735 PDC Pathway Commons Protein-Protein Interactions 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4XK-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sensory dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.619 Infertility, Male CTD Gene-Disease Associations 1.0 1.2046 CCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52206 SOX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21902 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.04853 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null P4HA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73074 Superior colliculus, superficial gray layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01631 BFAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36672 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF280B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68408 MYO18A Pathway Commons Protein-Protein Interactions 1.0 null GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null side of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.007697 USP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21003 CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37916 Perturb_13788_KO_Mcph1_SRP233207 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.75229 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18375 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.56904 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.68875 carbenoxolone-3353 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SW403 CCLE Cell Line Gene CNV Profiles 1.0 1.4258 0179445-0000-4758 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RAP1GAP Pathway Commons Protein-Protein Interactions 1.0 null BRD-A19766589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28602 GNGT2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K64353626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19671 BRD-K65183353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11252 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70516 BRD-K18070214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16998 BRD-K53662389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12535 Perturb_3650_KO_PI4KB_ERP115567 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.6627 myosmine-3634 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862691 C22orf23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73006 GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures -1.0 null SOCS3_DELETION_GDS1254_80_mouse_ES (embryonic stems cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null RAD54B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39053 paromomycin-3356 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22173 UPK3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89632 Thymic dendritic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.886 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.907116 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Eye-muller cell Tabula Sapiens Gene-Cell Associations 1.0 3.86549 hsa-miR-224 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Peptide hormone metabolism Reactome Pathways 2024 1.0 null CRCGN008_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8175 CST6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85033 HS600T CCLE Cell Line Gene Expression Profiles -1.0 -2.04139 WHSC1 ENCODE Transcription Factor Targets 1.0 null CACNB2 Pathway Commons Protein-Protein Interactions 1.0 null NDFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07413 GNG7 Pathway Commons Protein-Protein Interactions 1.0 null KMS27 CCLE Cell Line Gene CNV Profiles -1.0 -2.05916 Lobule III Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62743 BRD-K72098698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18441 BRD-K94647035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7502 Genital Diseases, Female CTD Gene-Disease Associations 1.0 1.10769 Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4849_KD_ZEB2_SRP059197 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.43869 Kidney Chromophobe_KICH_TCGA-KM-8442-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21897482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.88834 HCC70 CCLE Cell Line Gene CNV Profiles 1.0 1.39961 cinchonidine-2772 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_28_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null TCF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74304 mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25517 Anterior pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06505 ZR751 CCLE Cell Line Gene Expression Profiles 1.0 1.5756 UMUC11 DepMap CRISPR Gene Dependency 1.0 5.57894 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 WNT6 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K43029808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76984 BRD-K15202679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0419 Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34531 BRD-K63468420 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93026 ficolin-1-rich granule lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.629 Ovary epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.013 Main olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1003 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE128730_4_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2294 BRD-K07460436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.81287 cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42386 EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838194 Perturb_13077_KO_Cry2_SRP091906 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.47726 BRD-K46603043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62223 BRD-K24599650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.05604 GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null GALE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50989 GSE219195_0_v_5_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K11506071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24591 furafylline LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02871 Central lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53483 Mesothelioma_MESO_TCGA-MQ-A4LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07245666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26913 FGF7 Pathway Commons Protein-Protein Interactions 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_40_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17749 FCGR1A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K75657700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.06768 BRD-K45495792 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40064 G-protein activation Reactome Pathways 2024 1.0 null GATA1_G1E-ER4_mm9_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE238018_3_v_2_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193258,GSE193259_9_v_14_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K06237859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32223 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03769 CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.41533 hydralazine-2311 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54674 Dendritic knob COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.03 NCCRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95105 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.845068 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null pepstatin-3264 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE220813_0_v_1_zfp750_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellular process GO Biological Process Annotations 2015 1.0 null SOX9-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0004 lateral part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07076 GSE188870,GSE188871_0_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8ML-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMBC2 CCLE Cell Line Gene Expression Profiles -1.0 -2.11945 BRD-K25165359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47793 GSE199606_1_v_0_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_14116_KD_RPS6KB1_SRP187713 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.86927 etidronic acid-3325 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCIH1573 CCLE Cell Line Gene CNV Profiles -1.0 -1.56794 Perturb_16721_KO_Brca1_SRP094855 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.69874 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.953215 superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68954 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null preweaning lethality, incomplete penetrance IMPC Knockout Mouse Phenotypes 1.0 null Vomeronasal organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.533 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP-690334-01-4383 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FAM86B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43507 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36361 G beta:gamma signalling through PLC beta Reactome Pathways 2014 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null HOUAI DepMap CRISPR Gene Dependency 1.0 3.5374 lateral periretromammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18086 NRBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20808 Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10808 AP3M2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45016 phi1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.533 Tongue epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.232 plasma membrane GO Cellular Component Annotations 2015 1.0 null PCBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19986 Inwardly rectifying K+ channels Reactome Pathways 2024 1.0 null mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of the PBC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13699 mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77982 GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null GLO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89491 RBBP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65949 dilazep-3665 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_14004_OE_Kcnj2_SRP309478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CerebellumPeduncles BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.31352 Chemokine signaling pathway(Mus musculus) WikiPathways Pathways 2014 1.0 null Perturb_7553_Mut_FUS_SRP302857 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.84702 Olfactory ensheathing cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.866 GSE223540_1_v_3_anxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K36099605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02029 sc1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.064 F36P CCLE Cell Line Gene Expression Profiles -1.0 -1.6753 ChIP_SOX2_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAP3K7_knockout_246_GSE34417 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.30997 Lobule II, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50208 HS863T CCLE Cell Line Gene Expression Profiles -1.0 -1.52762 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42655 EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.6559 SKNO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.35254 CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30238 KDM4A ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bladder GTEx Tissue Gene Expression Profiles -1.0 -1.01387 DCAF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47879 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35924 BRD-K31721388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08624 CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.78964 BRD-K05060234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52232 HDAC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77886 G-protein beta:gamma signalling Reactome Pathways 2014 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05124 DST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42859 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 2.28499 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.69975 CRCGN015_HEPG2_48H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10469 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.79543 Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.724 NCKAP1 Pathway Commons Protein-Protein Interactions 1.0 null Taste transduction KEGG Pathways 2026 1.0 null mantle zone of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 response to nitrogen compound GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_51_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.87953 Vermal regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58994 Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K77032979 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3958 NCI-H810 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 KMS-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7811 ABI2 Pathway Commons Protein-Protein Interactions 1.0 null Cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.003 GSE210580_5_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAB5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48927 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03731 pyramidal cells of rostral CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.03792 GSE256181_2_v_3_etv2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.7874 TMEM121B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98126 FGF16 Pathway Commons Protein-Protein Interactions 1.0 null H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38679 Crus 2, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69365 extrinsic component of cytoplasmic side of plasma membrane GO Cellular Component Annotations 2025 1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null Rootlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.559 WNT8A Pathway Commons Protein-Protein Interactions 1.0 null Hypokalemic periodic paralysis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 BRD-K73574487 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03449 BRD-K28596345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96125 hsa-miR-142-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 CREB3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8039 BRD-K76691746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.51754 CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.14715 Germinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.0 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03548 EFM19 DepMap CRISPR Gene Dependency 1.0 5.88158 mantle zone of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38543 estradiol-5905 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15831 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.998175 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8287-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08097 Perturb_16980_KO_CD248_SRP402549 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.11872 Perturb_5265_KD_MiR290295_SRP331021 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.07836 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23129 G beta:gamma signalling through PI3Kgamma Reactome Pathways 2024 1.0 null Transmission across Chemical Synapses Reactome Pathways 2014 1.0 null sulfamerazine-3616 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2612 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05028 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56502 BRD-K80439500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19159 copper sulfate-500 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AKT3 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN012_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78975 SYK_knockdown_280_GDS3609 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.64707 inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.903977 BRD-K19734887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24211 NCIH2228 CCLE Cell Line Gene Expression Profiles -1.0 -1.54013 periventricular stratum of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41977 TRIM24 Pathway Commons Protein-Protein Interactions 1.0 null SRP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21263 ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KMT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31571 BRD-K27909962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14652 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3246 hsa-miR-4481 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_454_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K58774452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07875 GSE157383_3_v_2_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K44193634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31624 GSE195568_6_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null thp1 HPA Cell Line Gene Expression Profiles -1.0 -1.45928 Acute Myeloid Leukemia_LAML_TCGA-AB-2967-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX2-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null genistein-638 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null medial (fastigial) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07058 Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null BRD-K87343552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14757 SCG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67403 STAT3 ChEA Transcription Factor Targets 1.0 null BRD-K32019201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3539 suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86191 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.17165 CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.03885 CRCGN016_MCF10A.TP53.M_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74964 RPP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13955 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25937 MTURN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40492 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell body membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.729 Guanosine monophosphate HMDB Metabolites of Enzymes 1.0 null TOV21G DepMap CRISPR Gene Dependency 1.0 2.45616 BRD-K18316646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.90418 Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52404 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.78193 BRD-K07551625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41631 POU5F1-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P6-01A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucagon-type ligand receptors Reactome Pathways 2024 1.0 null cervix uteri GTEx Tissue Gene Expression Profiles -1.0 -1.01387 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64692 KARPAS299 CCLE Cell Line Gene CNV Profiles 1.0 2.42357 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DY-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SC-58125-507 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HNRNPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16852 SNTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21893 cellular response to peptide hormone stimulus GO Biological Process Annotations 2015 1.0 null KLB Pathway Commons Protein-Protein Interactions 1.0 null Perturb_16514_KD_Pou2f3_SRP343255 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.36035 BRD-K59960811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89745 BRD-K54023716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07791 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_12935_KD_CDK9_SRP340404 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.1516 CRCGN014_HEPG2_3H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08052 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.622616 BRD-K84636055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58089 GSE199606_1_v_0_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null FIGNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94237 Myometrial Relaxation and Contraction Pathways(Mus musculus) WikiPathways Pathways 2014 1.0 null E2F2_KD_GDS4094_447_mouse_Mammary tumors (Myc-induced) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K39498165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.28163 vinblastine-7517 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06005 CHD2 ENCODE Transcription Factor Targets 1.0 null CORO1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09353 CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.26017 BRD-K31977946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28415 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.861254 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.824055 BRD-K02671211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00807 KCNIP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07312 BRD-K63299069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01614 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.838308 GATA1_G1E-ER4_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K56591923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18353 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.277549 BRD-K52152765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09886 COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37565 BRD-K13807637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.876 ZIC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 88.835 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.876679 PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null Myometrial relaxation and contraction pathways WikiPathways Pathways 2024 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor-sensory cortex (samples)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49609 GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.935465 anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.895582 S3 proximal cell_Kidney_Mouse CellMarker Gene-Cell Type Associations 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Meningococcal infection_Umbilical vein_GSE4646 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -3.97863 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null ZNF549 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.2152 SCOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30805 GTF2IRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19887 TESK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02564 ADP signalling through P2Y purinoceptor 1 Reactome Pathways 2024 1.0 null Prostacyclin signalling through prostacyclin receptor Reactome Pathways 2024 1.0 null PIGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78843 Ras signaling WikiPathways Pathways 2024 1.0 null H3K27me3_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01773 Taste HuGE Navigator Gene-Phenotype Associations 1.0 null Perturb_11507_KD_ID1_SRP130910 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.88187 posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.908179 BRD-K44203030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35833 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.40633 Olfactory transduction KEGG Pathways 2026 1.0 null GNG12 Pathway Commons Protein-Protein Interactions 1.0 null PMC2801177__F3 PFOCR Pathway Figure Associations 2024 1.0 null HNRNPUL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99017 Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.49 GSE232714_0_v_1_raver1_human RummaGEO Gene Perturbation Signatures -1.0 null r1 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5387 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044717 periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03731 BRD-K57778236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09162 CRCGN014_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1066 ACOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40562 Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27667 AGMAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66048 dorsolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.961848 BRD-K13275816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65091 Perturb_17277_KO_Kdm1a_SRP185978 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.41087 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34110797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01759 4-P-PDOT LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27586 GSE240645_3_v_2_u90926_mouse RummaGEO Gene Perturbation Signatures 1.0 null Spermatheca TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.949 Metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.530103 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.24997 Perturb_17415_OE_Gata3_SRP150425 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.57163 AIF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74301 r2 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20249 HS939-T COSMIC Cell Line Gene Mutation Profiles 1.0 null JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.854734 BRD-K50677542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35643 BRD-K10459843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45226 ethambutol-4120 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87494 metixene-3313 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H28 GDSC Cell Line Gene Expression Profiles 1.0 1.77346 Perturb_10067_KD_EIF3A_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.82568 BCL3 ENCODE Transcription Factor Targets 1.0 null BRD-K19829092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02532 BRD-K90806964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04845 CRCGN014_HEPG2_3H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36114 CRCGN017_MCF10A.WT.HP_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18158 GSE203158_5_v_8_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_203_KD_Id1/ld3_SRP193147 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.39706 citiolone-3930 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64978 BRD-K29898553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03011 extrinsic component of cytoplasmic side of plasma membrane GO Cellular Component Annotations 2023 1.0 null mantle zone of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67133 HSC4 DepMap CRISPR Gene Dependency 1.0 2.476 MRPL55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61702 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K11577431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31408 Activation of G protein gated Potassium channels Reactome Pathways 2024 1.0 null BRD-K20171002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03955 Perturb_1256_KD_Prmt7_SRP279352 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.1731 cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.870947 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K54622858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44179 AKIRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46594 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC25A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03983 CD80 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 155.072 ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 132.297 cortex of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59296 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.82841 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC10938119-mmc1.docx-0-GATA6_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_15605_KO_Esrp1/Esrp2_SRP051370 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.4088 Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05831 HUT78 CCLE Cell Line Gene CNV Profiles -1.0 -1.39599 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 MOB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44572 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-4J-AA1J-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CACNB3 Pathway Commons Protein-Protein Interactions 1.0 null RGS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97119 BAIAP2 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of ITTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0482 BRD-K89742282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21127 46,XX sex reversal DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50498 BRD-K79619334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20648 BRD-K34405227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94829 ZNF548 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24361 cerebellar cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.62133 WNT5B Pathway Commons Protein-Protein Interactions 1.0 null male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056722 Morphine addiction KEGG Pathways 2026 1.0 null POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A69097282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50711 POLH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22551 BRD-K93496326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11669 RNA polymerase II termination complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.88 BRD-K67484361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30422 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTHFD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69258 CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.40183 PMC6883365__F2 PFOCR Pathway Figure Associations 2023 1.0 null Testicular somatic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.952 BRD-K94801143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5195 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8955_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -12.3481 PMC9376070-41419_2022_5157_MOESM15_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_of_CYTOR-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K92009052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06302 STAT1-17558387-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K79213964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34045 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50786 Perturb_4941_KO_Prdm14_SRP061948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.54856 Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05243 OPN1SW Pathway Commons Protein-Protein Interactions 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055849 Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164135,GSE164137_0_v_1_fbxw7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01309 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06207 CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1295 CRCGN014_HEPG2_3H:A05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04769 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_15_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.939067 BRD-K14399036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.5497 Trichinosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.209 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74205 SHSYSY-RA BioGPS Cell Line Gene Expression Profiles -1.0 -1.70039 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11129 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23346 BRD-K48171978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14467 CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8811 Perturb_13250_KO_Mettl14_SRP182641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.26172 small kidney IMPC Knockout Mouse Phenotypes 1.0 null BRD-K20454972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67718 CYP2D6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38298 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K07981644 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39215 HT-144 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.81969 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.81865 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79027 VCAP CCLE Cell Line Gene CNV Profiles -1.0 -1.38515 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null ZDHHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5661 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.54841 Rectum adenocarcinoma_READ_TCGA-AG-3731-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 113.845 PABIR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24214 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04307 Cribriform plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.214 NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02756 PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ZNF217_ER-Gene_Name_ZNF217 Rummagene Transcription Factor Associations 2026 1.0 null Presynaptic function of Kainate receptors Reactome Pathways 2024 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.02177 nimesulide-2275 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15721_KD_Brca1_SRP158188 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.38474 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.70734 U251 GDSC Cell Line Gene Expression Profiles -1.0 -1.41858 hydroxytoluic-acid LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30056 FGFR4 Pathway Commons Protein-Protein Interactions 1.0 null LOXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19968 IGHG3 Pathway Commons Protein-Protein Interactions 1.0 null Hypothalamic medial zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31389 Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MON DepMap CRISPR Gene Dependency 1.0 10.4265 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.36728 cellular_component GO Cellular Component Annotations 2015 1.0 null BECKER CCLE Cell Line Gene CNV Profiles 1.0 1.41741 suprofen-4123 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_1324_KD_RBM39_SRP301121 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 SMC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88292 BRD-K50212643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24655 PMC6883365__F1 PFOCR Pathway Figure Associations 2024 1.0 null mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K24108193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02994 Nr1h4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.6094 levopropoxyphene-3543 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SEC31A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23271 Perturb_7206_KD_U2AF1b_ERP006200 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.36953 Signal amplification Reactome Pathways 2014 1.0 null TTC549 DepMap CRISPR Gene Dependency 1.0 2.30275 HM7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.61791 Simple lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76421 TNKS_INHIBITION_GDS5029_280_human_SW480 KRAS-mutant colorectal cancer cell line - 4hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24619 CRCGN017_MCF10A.WT.HP_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1324 alpha-2-plasmin inhibitor deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.39 Sarcoma_SARC_TCGA-X6-A8C3-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89216747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91188 BRD-K15485967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26177 BRD-K01691949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.96401 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04973 ARTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01491 GSE131673_0_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Reactome Pathways 2014 1.0 null Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC8985862-Table3.XLSX-OTP-BRCA1_OTP Rummagene Transcription Factor Associations 2026 1.0 null single-organism metabolic process GO Biological Process Annotations 2015 1.0 null SMARCA4-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6634 GSE175787_13_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null PMC11328671-jitc-12-4-s003.pdf-127-GMEB2_GMEB2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A61767497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06727 kidney GTEx Tissue Gene Expression Profiles -1.0 -1.01387 SETSIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0208 mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null COV644 CCLE Cell Line Gene Expression Profiles 1.0 1.84242 PKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83714 mRNA_NRIP1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K87277021 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91561 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27157 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.078 BRD-K95963125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17234 BRD-K94742710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0795 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.10512 BRD-K78596805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82422 GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16136457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06148 Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF536 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21859 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38862 NAT14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91323 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05335 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GPCR ligand binding Reactome Pathways 2024 1.0 null H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular response to endogenous stimulus GO Biological Process Annotations 2015 1.0 null mRNA_TBX3_20139965 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null UHRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28941 TENM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30462 CRCGN015_MCF10A.WT.HP_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0865 RHO Pathway Commons Protein-Protein Interactions 1.0 null BRD-K24443173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23258 GSE89767_1_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures 1.0 null SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.76614 PRR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92992 Perturb_2667_KD_RBM39_SRP357624 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.27482 WNT9A Pathway Commons Protein-Protein Interactions 1.0 null ADRA2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34595 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null increased total body fat amount IMPC Knockout Mouse Phenotypes 1.0 null CRCGN014_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.00826 JOSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00043 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.908989 Cerebellar cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63895 MDAMB415 DepMap CRISPR Gene Dependency 1.0 2.15516 Thrombin signalling through proteinase activated receptors (PARs) Reactome Pathways 2014 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08833 GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4614 BRD-K82432417 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39201 SARS-CoV_12Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.90013 CISD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78149 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06505 GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null RAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2346 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21332842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29446 increased circulating glucose level MGI Mouse Phenotype Associations 2023 1.0 null Hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC10870497-13046_2024_2976_MOESM12_ESM.pdf-20-FOXD1_FOXD1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K14268329 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03251 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_62_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05182 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_16518_KD_Pou2f3_SRP343255 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 ABHD17C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37783 H-89-6878 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7738984__F8 PFOCR Pathway Figure Associations 2024 1.0 null BRD-K27331198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20385 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_38_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6929403__F2 PFOCR Pathway Figure Associations 2023 1.0 null BRD-K66577743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18586 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.89316 POU5F1-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.TP53.M_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.05735 Perturb_7753_KD_PCF11_SRP175016 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.55322 Anterior cingulate area, dorsal part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01381 BRD-K62369921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06487 GSE206870,GSE206872_1_v_5_ascl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null G alpha (s) signalling events Reactome Pathways 2024 1.0 null GLI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42927 BRD-K51608472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26462 NCIH716 CCLE Cell Line Gene CNV Profiles 1.0 1.4686 cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DHRS13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5505 Learning Disorders CTD Gene-Disease Associations 1.0 1.26205 intermediate stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25937 MSN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17213 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.6032 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null domaincontaining GeneRIF Biological Term Annotations 1.0 null Adrenaline,noradrenaline inhibits insulin secretion Reactome Pathways 2014 1.0 null BRD-K27137352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77465 DPYSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85741 YH-13 GDSC Cell Line Gene Expression Profiles 1.0 2.02441 SHOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01083 Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.0718 Ca2+ pathway Reactome Pathways 2024 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PITPNM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06417 GSE162892_4_v_5_isox_human RummaGEO Drug Perturbation Signatures 1.0 null MT-ND4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12654 BRD-K96023136 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28532 ERBB2_knockdown_235_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.6536 IDO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67982 Paramedian lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.749 CAMA1 DepMap CRISPR Gene Dependency 1.0 3.7433 CRCGN016_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56726 Inflammation CTD Gene-Disease Associations 1.0 1.03641 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.58932 proglumide-3972 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null prepontine hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32923 PSMB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7255 POLG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4965 LRP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0923 FGF2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K07278815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2359 BRD-K95913506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04589 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.64744 CARMIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05381 NHLRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20928 retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21788 BRD-K17749779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0517 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02289 sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054347 GSE169356_2_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0136 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.948628 CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8406 orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06249 Mucolipidosis III gamma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.367 FAM221A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7878 HN COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36628 GSK3B_knockdown_208_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.51104 GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN010_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.3416 Lobule III, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.724 GATA1 ENCODE Transcription Factor Targets 1.0 null LRP5 Pathway Commons Protein-Protein Interactions 1.0 null MORCPR CCLE Cell Line Gene Expression Profiles 1.0 1.35221 ZNF692 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.545 CRCGN016_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40097 TMEM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60291 SNU-283 COSMIC Cell Line Gene Mutation Profiles 1.0 null OPN1MW Pathway Commons Protein-Protein Interactions 1.0 null SRY ChEA Transcription Factor Targets 1.0 null UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 BRD-K95666495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13035 orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17083 BRD-K59922784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80229 CRCGN015_MCF10A_48H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23997 Perturb_13265_KO_chr3_SRP162484 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Autism spectrum disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14783 CRCGN016_MCF10A.TP53.M_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01021 PPARA_agonist activation_GSE17251_474_human_Isolated hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null WNT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC7754529__F3 PFOCR Pathway Figure Associations 2024 1.0 null GATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62177 metampicillin-2286 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JUN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43524 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS Rummagene Transcription Factor Associations 2026 1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.958136 Infectious disease Reactome Pathways 2024 1.0 null GSE232631_0_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.988284 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68585 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r2 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19483 PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K17582293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20484 FGF8 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.245 Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11872 tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.863241 ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.835 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40786 FYN Pathway Commons Protein-Protein Interactions 1.0 null G alpha (q) signalling events Reactome Pathways 2024 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883635 MRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47498 Dorsum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.197 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Calcium Regulation in the Cardiac Cell(Mus musculus) WikiPathways Pathways 2014 1.0 null GSE232472_1_v_2_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-A17658676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08192 NR0B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40142 BRD-K45893504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.22726 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null energy derivation by oxidation of organic compounds GO Biological Process Annotations 2015 1.0 null Heterotrimeric G-protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.111 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.38717 internal granular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61934 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.49 Signaling by GPCR Reactome Pathways 2014 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.266 BRD-K69817695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19245 GSE65617_5_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:F11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09832 PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.062127 Perturb_16466_KO_Tnfsf12_SRP102352 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.42515 CORL311 CCLE Cell Line Gene Expression Profiles 1.0 3.40793 VCAP DepMap CRISPR Gene Dependency 1.0 2.52421 MG63 CCLE Cell Line Gene Expression Profiles -1.0 -2.00077 BRD-K37588779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20963 Perturb_3385_OE_miR155_SRP108825 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.9378 VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.5192 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17961 SDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12569 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP-944629-7544 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_1805_KO_Myd88_SRP377807 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.78127 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.82761 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.969561 NCIH2347 CCLE Cell Line Gene CNV Profiles -1.0 -1.45272 FNDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83312 hsa-miR-2392 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE69244_1_v_0_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.31723 dorsolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.41531 Brain Lower Grade Glioma_LGG_TCGA-S9-A89V-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.82687 B3GALT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87603 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052543 TMEM88_KD_GSE43805_682_human_hES cells differentiated along the cardiac lineage GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CHST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51241 GSE242083,GSE242098_2_v_5_med1_human RummaGEO Gene Perturbation Signatures -1.0 null Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.5557 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02755 FZD4 Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02749 Nose TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.702 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.874717 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.99127 abnormal uterus morphology IMPC Knockout Mouse Phenotypes 1.0 null prednisone-1478 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.980231 BRD-K11504077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24442 GSE175787_11_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF460 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83254 ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 169.417 mRNA_SALL4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.995311 GSE227592_9_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K50177531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41493 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_75_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.97461 NCIH2291 CCLE Cell Line Gene Expression Profiles 1.0 1.41214 BRD-K63394284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.679 EP300 ENCODE Transcription Factor Targets 1.0 null BRD-K51196703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13916 ZNF628 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40601 COQ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27846 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864202 BRD-K71204648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74798 Perturb_17688_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.41666 PDPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20661 BRD-K99521908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26898 ACC3 BioGPS Cell Line Gene Expression Profiles 1.0 1.13725 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862691 STRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57663 GSE173911,GSE173917_0_v_1_morc3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PDPK1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8004 BRD-K35639494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43769 HMGN3 ENCODE Transcription Factor Targets 1.0 null Perturb_1813_KO_N4bp1_SRP255180 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.56665 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction PANTHER Pathways 1.0 null BRD-K95499061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03914 DEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73116 BRD-K45909830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.16813 carteolol-3276 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OPN3 Pathway Commons Protein-Protein Interactions 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null GSE88819_7_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null nb4 HPA Cell Line Gene Expression Profiles -1.0 -1.45928 BRD-K20829034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58384 cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33799 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19505 Tracheal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.892 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0437 CRCGN011_HEPG2_24H:J13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45605 iodixanol-4848 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90997 ADRBK1 Pathway Commons Protein-Protein Interactions 1.0 null PMC11462941-CAS-115-2947-s001.pdf-75-ZNF654_ZNF654 Rummagene Transcription Factor Associations 2026 1.0 null CDC42EP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69695 GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures -1.0 null Intrinsic component of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.468 CRCGN017_MCF10A.WT.HP_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01625 MSTO211H DepMap CRISPR Gene Dependency 1.0 3.30786 KYSE30 CCLE Cell Line Gene Expression Profiles 1.0 1.58675 parahippocampal gyrus, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.848283 ERBB2_knockdown_237_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.69576 BRD-K31530457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64117 ERCC6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24832 BRD-K61795707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28408 primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3094 CRCGN015_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.31791 RABAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03396 RXRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60832 cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.38474 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79085 T-cell immunodeficiency, congenital alopecia, and nail dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.395 Perturb_15651_OE_Ccnj_DRP008918 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.31434 CACNG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50749 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.838069 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4887 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55748 ZMYM2 Pathway Commons Protein-Protein Interactions 1.0 null DEOC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54173 Perturb_5173_KD_Hnrnpk_SRP078486 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.3108 mRNA_NR5A2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.72162 ascorbic acid-3225 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null neuron projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.067223 BRD-K71671197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01909 G-protein beta:gamma signalling Reactome Pathways 2024 1.0 null retina TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.284607 PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR Rummagene Transcription Factor Associations 2026 1.0 null FGFR1OP2 Pathway Commons Protein-Protein Interactions 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BECKER COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100356_TCx_probable Alzheimer's disease_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.036 RTL8C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83512 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39364 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.63692 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19387 fluvoxamine-4114 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_17788_KD_Elavl1_SRP284054 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.41558 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2A MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN017_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.58695 GNGT1 Pathway Commons Protein-Protein Interactions 1.0 null ZFP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7474 BAS-012416453-6880 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K13301506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49806 Calcium regulation in cardiac cells WikiPathways Pathways 2024 1.0 null H3K27me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15106 GTPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.09 RAD23B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77434 cone-rod dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20998 response to hormone GO Biological Process Annotations 2015 1.0 null shell of SCH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31389 GSE125014_6_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Plastron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.557 aciclovir-5278 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.89255 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27797 CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81589 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sulfaguanidine-1495 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047716 FOXP1 ChEA Transcription Factor Targets 1.0 null CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.33236 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Perturb_10027_KD_APOBEC3C_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.92403 NCI-H526 GDSC Cell Line Gene Expression Profiles 1.0 2.68447 protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.91411 MBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59395 hsa-miR-513a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Hypertrophy CTD Gene-Disease Associations 1.0 1.41396 nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.038101 PMC5228698__F1 PFOCR Pathway Figure Associations 2024 1.0 null Mesothelioma_MESO_TCGA-LK-A4O2-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tanespimycin-5914 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null molecular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57957 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NECAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11286 Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61298 primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00534 Reflex, Abnormal CTD Gene-Disease Associations 1.0 1.22209 imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GRB2 Pathway Commons Protein-Protein Interactions 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6510-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2279 CCLE Cell Line Gene CNV Profiles 1.0 1.80561 BRD-K84348716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00898 BRD-K08835142 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16962 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838194 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29881 PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE175571_3_v_2_acsl6_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79534 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11129 NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3022 CTCF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 227.313 ZR75_1 BioGPS Cell Line Gene Expression Profiles 1.0 0.867093 r2 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19632 GSE118490_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null EXOSC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25352 CRCGN014_HEPG2_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.12029 supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05405 EMILIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36449 mitochondrion LOCATE Predicted Protein Localization Annotations 1.0 null HCC15 CCLE Cell Line Gene Expression Profiles 1.0 1.60466 BRD-K78818514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.318 Perturb_13069_KO_Cry2_SRP091906 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.41472 Perturb_5562_KO_MTSS1_SRP266832 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.40784 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null catalytic complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.001651 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 GSE180200,GSE180201_2_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null Anterior olfactory nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00634 brain GTEx Tissue Gene Expression Profiles 1.0 2.18987 Perturb_14003_OE_Kcna2_SRP309478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.56708 Kaposi sarcoma-associated herpesvirus infection KEGG Pathways 2026 1.0 null CD86 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K99116119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01114 MYSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15671 ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.830316 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.829705 BRD-K50127933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.16887 Activation of kainate receptors upon glutamate binding Reactome Pathways 2024 1.0 null Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K44582497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21793 OLIG2-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76755163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0001 Aquaporin-mediated transport Reactome Pathways 2014 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K49298555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06883 HMGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11614 SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPMI 8226 BioGPS Cell Line Gene Expression Profiles -1.0 -0.952608 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K75900642 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51487 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.239 Perturb_15747_KO_Cnga1_SRP327351 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.8927 Lamina epithelialis mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.701 ZNF823 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69841 CRCGN017_MCF10A.TP53.M_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07948 CRCGN015_MCF10A_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45578 decreased body size MGI Mouse Phenotype Associations 2023 1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05207 BRD-K33454318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1556 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 GATA3 ChEA Transcription Factor Targets 1.0 null BRD-K23840704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37455 ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 69.8465 P3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45626 BRD-K28467941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09784 Perturb_13206_OE_Klf3_SRP281992 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.0151 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02366 MRPL51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93358 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1394_KO_miR290295_SRP326983 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.07836 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.7079 clofilium tosylate-6830 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K42873980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64266 FZD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77944 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07137 benzonatate-5435 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC5522997__F9 PFOCR Pathway Figure Associations 2023 1.0 null CTAGE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42332 SP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13676 Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GM97 BioGPS Cell Line Gene Expression Profiles 1.0 1.05327 JUND ENCODE Transcription Factor Targets 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.970701 Perturb_15671_KD_Cebpb_SRP160879 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.3741 hsa-miR-4437 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Ubisch body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.559 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52845 BRD-K70198986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06019 Perturb_15635_KO_MAT2A_SRP351305 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.51049 Perturb_1895_KO_Trem2_SRP173901 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.03376 KMBC2 DepMap CRISPR Gene Dependency 1.0 2.75003 EGR4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.6549 fenbufen-3618 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Persistent Mullerian duct syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.119 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD28 Pathway Commons Protein-Protein Interactions 1.0 null MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833512 Glucagon signaling in metabolic regulation Reactome Pathways 2024 1.0 null Toe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.774 LEMD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94175 NFI-21473784-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_1690_KD_Kdm4c_ERP009549 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.89828 dorsolateral part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19213 Perturb_15107_KD_EWSR1_SRP169096 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.42512 RHBDL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89598 small intestine HPA Tissue Protein Expression Profiles 1.0 1.26996 LOUCY CCLE Cell Line Gene CNV Profiles -1.0 -2.05457 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1703 FKBP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08249 isthmic alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41897 SRI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41522 CRCGN016_MCF10A.TP53.M_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17776 Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050675 TRAPPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99229 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cri-Du-Chat syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.086 mRNA_GADD45A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GNG5 Pathway Commons Protein-Protein Interactions 1.0 null Simple lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74692 BRD-K94196749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6756 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37273 ITK Pathway Commons Protein-Protein Interactions 1.0 null PYGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84002 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRELD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15538 Perturb_7292_KI_KMT2C_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.41623 BRD-K99074976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07735 Vasopressin regulates renal water homeostasis via Aquaporins Reactome Pathways 2024 1.0 null BHT101 DepMap CRISPR Gene Dependency 1.0 2.96102 Regulation of insulin secretion Reactome Pathways 2024 1.0 null BRD-K28774883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76079 Ras signaling pathway KEGG Pathways 2026 1.0 null GPSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47739 hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.589211 Infertility, Female CTD Gene-Disease Associations 1.0 1.12426 GRK6 Pathway Commons Protein-Protein Interactions 1.0 null ZBTB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73625 frontal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27667 subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00505 NB6 GDSC Cell Line Gene Expression Profiles 1.0 1.48274 PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.283 Dopaminergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.516 TRIM28_knockout_301_GSE32224 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.36585 cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.30576 MAX ENCODE Transcription Factor Targets 1.0 null GSE176093_0_v_1_mineral oil_mouse RummaGEO Drug Perturbation Signatures 1.0 null Anterior cingulate area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45488 Perturb_7875_KD_H2A.Z.2_SRP259021 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.59049 flumetasone-4734 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Subparaventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13946 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Perturb_10030_KD_EIF4G2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.73082 Scolopidium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.478 GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_45_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null CAL-27 GDSC Cell Line Gene Expression Profiles -1.0 -1.52525 GSE184356_3_v_2_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_5859_KD_Lap2_SRP287033 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.04425 UNC119B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85074 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04399 Hic1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2024 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37967 C3orf52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66221 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.21272 CRCGN016_MCF10A.TP53.M_24H:C18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.951 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.43932 PMC3775648__F3 PFOCR Pathway Figure Associations 2024 1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chaperonin-mediated protein folding Reactome Pathways 2024 1.0 null arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5707 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2756 GSE139966_1_v_0_figla_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.42131 GSE207514,GSE207515_0_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 167.915 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.89983 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_270_KO_ADIRFAS786_SRP366780 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.22297 Mesonephron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.349 Adrenaline,noradrenaline inhibits insulin secretion Reactome Pathways 2024 1.0 null CRCGN014_HEPG2_3H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06735 superficial stratum of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18086 Extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.855396 BRD-K50240676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39034 TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.6425 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.953121 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAMOS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7541 GSE138672_0_v_1_rabgef1_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07076 Prostate adenocarcinoma_PRAD_TCGA-CH-5772-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K08431704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37275 Human cytomegalovirus infection KEGG Pathways 2026 1.0 null BRD-K20745677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47472 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03521 PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K34343777 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43478 S100A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51074 HDAC1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1033 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06198 PHA-00745360-4384 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Genital primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.835 Pancreas BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.849716 BRD-K27881453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.87396 g-protein beta-subunit binding GO Molecular Function Annotations 2015 1.0 null CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.895278 nalbuphine-2225 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.81574 synapse SynGO Synaptic Gene Annotations 1.0 null Sensillum trichodeum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.073 CRCGN016_MCF10A.TP53.M_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00815 Perturb_5649_KD_MYBL2_SRP161768 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 organelle LOCATE Predicted Protein Localization Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_17767_KO_Prdm16_SRP238935 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.32926 BRD-K19862308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29395 BRD-K98355012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01073 BRD-K48389907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1578 BRD-K16047442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01007 OB inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4932 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.898521 seneciphylline-4822 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hemostasis Reactome Pathways 2024 1.0 null ZNF213 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.4847 Prestwick-981-6504 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE241031_0_v_4_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16392 BRD-A68842442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03425 NCIH2004RT DepMap CRISPR Gene Dependency 1.0 3.54803 nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15986 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null FAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97908 GSE258991_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_7423_KD_DKC1_SRP045222 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.9057 CRCGN017_MCF10A.TP53.M_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21297 ESR1-20056654-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular response to hormone stimulus GO Biological Process Annotations 2015 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null SNU840 DepMap CRISPR Gene Dependency 1.0 2.75413 hsa-miR-1228 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 ZNF281 ChEA Transcription Factor Targets 1.0 null SOX2-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.98916 JcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03171 BRD-K67525206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2681 IGSF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9006 Metabolism Reactome Pathways 2014 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8097-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cloxacillin-2289 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.TP53.M_24H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1305 SARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84337 FGF18 Pathway Commons Protein-Protein Interactions 1.0 null SLR25 CCLE Cell Line Gene CNV Profiles 1.0 2.02867 CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.19499 small intestine GTEx Tissue Gene Expression Profiles 1.0 1.10182 Main olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37453 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047018 Paramedian lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85873 CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5898 Ebolavirus(EBOV)_1day_Splenocytes_19683682_GSE17509 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.01989 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null isthmic roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2067 HES6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4873 ACTR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23993 NAMPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38611 GSE148692,GSE148695_5_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K42754852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40236 GSE120336_0_v_2_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K33102216 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91883 BRD-A71666580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35269 ESET_KO_GDS4508_348_mouse_Dorsal telencephalon from E14.5 embryos GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_3202_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.69695 PLAAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65541 cytoplasmic side of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Perturb_13264_KO_chr7_SRP162484 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.5845 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05267 WNT2B Pathway Commons Protein-Protein Interactions 1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.81775 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92299 IGLC6 Pathway Commons Protein-Protein Interactions 1.0 null RNF166 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10858 BRD-K71538933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2549 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.59918 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K79604175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15397 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29816 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.9067 Perturb_3733_KO_Trp53_SRP296860 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.4143 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12943 catalytic complex GO Cellular Component Annotations 2015 1.0 null cellular response to organonitrogen compound GO Biological Process Annotations 2015 1.0 null lateral parabrachial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14208 JHUEM1 DepMap CRISPR Gene Dependency 1.0 2.68118 BRD-K27621887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34923 hsa-miR-4745-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 PMC5522997__F9 PFOCR Pathway Figure Associations 2024 1.0 null CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.8384 H3K27me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null peripheral nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.388158 Glutamatergic synapse KEGG Pathways 2026 1.0 null BRD-K68364310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64689 biological_process GO Biological Process Annotations 2015 1.0 null GSE139975_3_v_0_rnf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_9152_KD_DDX21_SRP327839 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.50589 HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -1.21149 presynaptic active zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.6638 CRCGN012_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6622 plasma membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36192 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.925432 BRD-K03884263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.80969 MBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95527 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GNG8 Pathway Commons Protein-Protein Interactions 1.0 null FRAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48679 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.864448 Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.44345 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11616 FGFR1OP Pathway Commons Protein-Protein Interactions 1.0 null AR-35413990-HUMAN-ARPOSCRPROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.93977 Calcium Regulation in the Cardiac Cell(Homo sapiens) WikiPathways Pathways 2014 1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26694 BRD-K31844308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0488 Endothelin pathways WikiPathways Pathways 2024 1.0 null BRD-K81175414 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.19006 BRD-K84457681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83844 BRD-K58933168 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55949 CRCGN014_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.12628 Ca2+ pathway Reactome Pathways 2014 1.0 null ZNF790 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54608 neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.11154 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 cellular response to chemical stimulus GO Biological Process Annotations 2015 1.0 null Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74205 BRD-K46623934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16014 ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 191.884 ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1439 PMC4783780__F8 PFOCR Pathway Figure Associations 2023 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null Lateral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39661 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72060858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13949 MED12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1988 LRRN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04695 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6483 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null alfaxalone-6514 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KL Pathway Commons Protein-Protein Interactions 1.0 null OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.6719 cell surface receptor signaling pathway GO Biological Process Annotations 2015 1.0 null HMX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30624 OVTOKO CCLE Cell Line Gene Expression Profiles 1.0 1.57521 DNAAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88968 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04074 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883635 FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K24133768 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08786 PMC7754529__F3 PFOCR Pathway Figure Associations 2023 1.0 null Parasitic Infection Pathways Reactome Pathways 2024 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22514 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883635 myricetin-3270 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PANX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10941 Plasma membrane protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 mRNA_SOX2_16767105 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883635 sublayer 6b of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45488 BRD-K46949676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08238 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 superficial stratum of FCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28561 CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16165 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.962054 Perturb_14214_KO_App_SRP254653 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.84091 Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null response to endogenous stimulus GO Biological Process Annotations 2015 1.0 null Circadian entrainment KEGG Pathways 2026 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13673722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1524 HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1964 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27571 GSE48812_3_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null HSPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86257 klf4_17017123_rko_gof_human_gpl96_gds1942 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.328647 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.87813 BRD-K00909602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04695 Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78173 BRD-K17060750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.36943 BRD-K16255400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20607 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.121178 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null GDF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86365 TSTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59125 H3K27me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.82426 GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.10949 primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.860608 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.83116 acetylsalicylsalicylic acid-2223 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null heterotrimeric G-protein complex GO Cellular Component Annotations 2023 1.0 null Mucin granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.75 NCIH2227 CCLE Cell Line Gene Expression Profiles 1.0 1.92204 trichlormethiazide-3337 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K24343201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27937 BRD-K47143916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9976 TE5 CCLE Cell Line Gene CNV Profiles 1.0 1.73862 PGR-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null RBM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84485 NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17053 CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.07922 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17448 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85314 GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEPTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9302 H3K27me3_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00771 TT2609C02 CCLE Cell Line Gene CNV Profiles -1.0 -1.41611 r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02238 BRD-K47200630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42394 FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RHOA Pathway Commons Protein-Protein Interactions 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_17677_KO_Foxa2_SRP139796 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.44884 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.868336 GSE242290_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_7336_KD_SUGP1_SRP286876 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.51607 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K93774122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17346 Neuroactive ligand signaling KEGG Pathways 2026 1.0 null gh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.88 mcf7 HPA Cell Line Gene Expression Profiles 1.0 1.86938 BRD-K76329122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10953 GSE154253_1_v_0_tnfaip8_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5505-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21579116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07043 BRD-K99048639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38008 BRD-K67715154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35858 BRD-K82130737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10561 BRD-K90686530 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18863 GSE112763,GSE112767_0_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28439 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MU-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13456_OE_Smn1_SRP366489 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.46838 TFAP2C JASPAR Predicted Transcription Factor Targets 1.0 null ALDH1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99777 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06535 CRCGN010_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.93341 Thromboxane signalling through TP receptor Reactome Pathways 2014 1.0 null Rotator Cuff Syndrome DisGeNET Gene-Disease Associations 1.0 null PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B Rummagene Transcription Factor Associations 2026 1.0 null Thymic cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.613 BRD-K71296038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04957 BRD-K69241192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83422 Perturb_5757_KO_C9orf72/Tmem173_SRP266242 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.43338 BRD-K40738002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78539 AKTIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22066 BRD-A73965025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08931 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lobule II Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38628 BRD-K76588081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15731 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.914587 spiramycin-3938 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome Pathways 2024 1.0 null NAA60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49021 G-401 GDSC Cell Line Gene Expression Profiles 1.0 2.6663 Perturb_272_KO_ADIRFAS786_SRP366780 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.46632 system process GO Biological Process Annotations 2015 1.0 null CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5631 superficial stratum of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33327 BRD-K63573625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75604 BRD-K72224143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14707 mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18579 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.06055 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null guaifenesin-2569 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null E2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6607 digoxin-3283 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DCAF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51062 mediodorsal nucleus of thalamus_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03809 Perturb_17263_KO_Gja1_SRP247546 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.56934 RAC1 Pathway Commons Protein-Protein Interactions 1.0 null III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32451 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bietti crystalline corneoretinal dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.579 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.956089 CRCGN011_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2904 GSE125014_6_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K47471281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.10393 PMC8874499__F3 PFOCR Pathway Figure Associations 2024 1.0 null Olfactory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.897 FEM1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21144 ChIP_TCF3_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null G-protein, gamma subunit InterPro Predicted Protein Domain Annotations 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11846 Puberty, Precocious CTD Gene-Disease Associations 1.0 1.0561 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K24020784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9694 BRD-K64811593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57409 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7210_KD_U2AF1b_ERP006200 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.36596 retromammillary area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00933 HT GDSC Cell Line Gene Expression Profiles 1.0 1.82099 H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.07263 SHC1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K56041932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44447 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875482 FGFR1 Pathway Commons Protein-Protein Interactions 1.0 null hycanthone-5691 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28538 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PJVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61496 Submucosal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.702 PG cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.039 CACNA1E Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7474-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fetal Brain Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.865224 HPBALL CCLE Cell Line Gene CNV Profiles -1.0 -1.83688 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.960466 Perturb_16665_KO_Slc27a2_SRP186493 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.7297 PITX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42503 Mature neuron_Olfactory neuroepithelium_Human CellMarker Gene-Cell Type Associations 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.39847 phenacetin-4111 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4669 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.874092 GSE187005_5_v_2_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE149880_0_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null PTGR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03855 LY-294002-5937 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 496100669_FWM_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13408 cellular response to nitrogen compound GO Biological Process Annotations 2015 1.0 null plicamycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16913 BRD-K84052780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49789 OVK-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39468 GB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K73608149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11482 Endothelin Pathways(Homo sapiens) WikiPathways Pathways 2014 1.0 null metaraminol-4692 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40262 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null retina BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0516 SCAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27164 BRD-K62800316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09996 GATA3-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null nitrendipine-336 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66787 CLCN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71111 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6049 Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22113 BRD-K54637865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74252 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.33316 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.44018 CRABP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89782 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.903959 GPR160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82315 Perturb_1382_KO_Sdc1_SRP286584 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.26005 Sensory Perception Reactome Pathways 2024 1.0 null CCDC28A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14572 CRAMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57458 AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72399 HS737T CCLE Cell Line Gene Expression Profiles -1.0 -2.11182 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TC71 CCLE Cell Line Gene Expression Profiles 1.0 1.38591 AKT1 Pathway Commons Protein-Protein Interactions 1.0 null ARAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14169 FGFR1_knockdown_94_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.76423 BRD-K96651591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2483 precommissural pretectal domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18786 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16829 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCB000038-7542 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null aminohippuric acid-5394 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null indoprofen-3345 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.91411 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 STAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55882 cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71 IGHG2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_2797_KD_RORC_SRP066204 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.99414 KLF5 JASPAR Predicted Transcription Factor Targets 1.0 null SUPB15 CCLE Cell Line Gene CNV Profiles -1.0 -1.63769 BRD-K56572622 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21474 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LRRFIP1 Pathway Commons Protein-Protein Interactions 1.0 null Rhinencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.995 PLCG2 Pathway Commons Protein-Protein Interactions 1.0 null ZMIZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86025 AGRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95411 BRD-K31836496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55702 MHHCALL3 CCLE Cell Line Gene Expression Profiles -1.0 -1.46688 TCF3-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null AP-4 MotifMap Predicted Transcription Factor Targets 1.0 null tiratricol-2259 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K99302735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50219 GSE240645_1_v_0_u90926_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24 Rummagene Transcription Factor Associations 2026 1.0 null rostral secondary prosencephalon Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24273 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Reactome Pathways 2014 1.0 null Lobule III, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56299 GOTO GDSC Cell Line Gene Expression Profiles -1.0 -1.57737 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3064 periventricular stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48044 Crus 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6659 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A95207036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2472 oxidation-reduction process GO Biological Process Annotations 2015 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.5401 CRCGN012_HEPG2_24H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13775 response to organonitrogen compound GO Biological Process Annotations 2015 1.0 null metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K55835264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01998 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Reactome Pathways 2024 1.0 null BRD-K48670593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33099 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41429 extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 WNT4 Pathway Commons Protein-Protein Interactions 1.0 null putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39754 primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.992403 DEDD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67255 BRD-K87383650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12842 NCIH1650 CCLE Cell Line Gene Expression Profiles 1.0 1.38746 CRCGN017_MCF10A.TP53.M_24H:M04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.23894 BRD-K90697693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4157 BRD-K28057105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51873 Transmission across Chemical Synapses Reactome Pathways 2024 1.0 null BCL3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14117_KD_RPS6KB1_SRP187713 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.4075 MCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19022 EZH2_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.6143 H3K27me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ENSG00000170846 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69918 Ethmoid bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.198 TMEM88B_KD_GPL10558_471_human_cardiovascular progenitors cells differentiated from hES cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null octopamine-6491 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null clorgiline-3219 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_13644_KD_Trim28_SRP126388 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.16587 ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.86 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.516 C19orf47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3997 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LD-01A-12R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.04357 BRD-K48634117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35336 PMC4783780__F8 PFOCR Pathway Figure Associations 2024 1.0 null CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.43214 BRD-K73839552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9722 WNT7B Pathway Commons Protein-Protein Interactions 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null TOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64595 TCCPAN2 CCLE Cell Line Gene CNV Profiles 1.0 1.45817 CAL33 CCLE Cell Line Gene CNV Profiles 1.0 1.55968 CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.155 GPCR ligand binding Reactome Pathways 2014 1.0 null PTS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96516 LRP6 Pathway Commons Protein-Protein Interactions 1.0 null GSE148692,GSE148695_5_v_4_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.919146 citalopram-4377 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE231799_2_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10985 BRD-K21732483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55286 dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20123 BRD-K83902026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14487 canadine-4138 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43074 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.8409 PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.962054 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hormone signaling KEGG Pathways 2026 1.0 null CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.55259 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72821236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55031 acenocoumarol-2240 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GNB3 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_60_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null chlorphenesin-2279 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9454 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K60631127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51849 496100368_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21047 ECHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28919 paclitaxel-640 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r3 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.095 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.077 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.930795 thioridazine-5916 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72265 PMC8063444__F5 PFOCR Pathway Figure Associations 2024 1.0 null GBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55051 chlorcyclizine-4367 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48263 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.06415 Perturb_1893_Mut_Trem2_SRP173901 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.76643 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.284 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31083 H3K27me3_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G protein signaling WikiPathways Pathways 2024 1.0 null SGPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22587 Perturb_12884_KO_Ccnk_SRP127682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.50912 r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05993 GSE76425_0_v_5_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null GCIY CCLE Cell Line Gene CNV Profiles 1.0 1.45857 CEBPA-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-A09115727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47891 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.73427 SFSWAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43299 FZD1 Pathway Commons Protein-Protein Interactions 1.0 null HSF1_KD_GDS1733_750_human_HeLa cells - 0 Hour GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Thrombin signalling through proteinase activated receptors (PARs) Reactome Pathways 2024 1.0 null JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.07532 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.01332 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6623 Signaling by GPCR Reactome Pathways 2024 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2554 hela HPA Cell Line Gene Expression Profiles 1.0 1.02939 LAPTM4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40728 superficial stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19483 TBC1D22B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93785 furazolidone-3358 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YAPC CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 HDAC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03569 roxithromycin-3331 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.42098 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.91488 G alpha (12/13) signalling events Reactome Pathways 2024 1.0 null BRD-K11700411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21927 ZNF710 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7631 HEL CCLE Cell Line Gene Expression Profiles -1.0 -1.46628 BRD-K81501934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19101 GSE231799_3_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30428 Integration of energy metabolism Reactome Pathways 2024 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGKV1-5 Pathway Commons Protein-Protein Interactions 1.0 null VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00472 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.891159 lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16637 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18908 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50452 GABA-ergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.557 ZC3H12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1726 Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gramine-4118 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null multiform (lateral) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.869383 BRD-K28753508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3351 BRD-K53387776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29244 CCDC177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11927 Copula pyramidis, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29615 BRD-K99077411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52903 response to chemical GO Biological Process Annotations 2015 1.0 null caco2 HPA Cell Line Gene Expression Profiles 1.0 1.13983 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.39655 BRD-K80535598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0055 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Perturb_11340_KD_Mll4_SRP241682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.88811 Utricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.669 LIN7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69326 Perturb_14945_KD_Parp1_SRP102079 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.3375 Perturb_14110_OE_C11orf53/Pou2f3_SRP343255 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 17.9547 PMC11046693-pnas.2320938121.sapp.pdf-116-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null GSE131649_4_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null RYBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83938 GNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51573 Guanosine triphosphate HMDB Metabolites of Enzymes 1.0 null PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10722 WNT3 Pathway Commons Protein-Protein Interactions 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_77_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K15882320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25184 JHOM2B CCLE Cell Line Gene CNV Profiles -1.0 -1.74919 TACSTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77875 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056914 Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS821T CCLE Cell Line Gene CNV Profiles 1.0 1.4306 GRK5 Pathway Commons Protein-Protein Interactions 1.0 null KMRC1 DepMap CRISPR Gene Dependency 1.0 6.26941 PWWP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60301 TMEM184B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17871 Perturb_4940_KO_Cbfa2t2_SRP061948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.32325 ITPR3 Pathway Commons Protein-Protein Interactions 1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17365 dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04021 TCF3-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null cellular response to organic substance GO Biological Process Annotations 2015 1.0 null BRD-K41993678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20202 Neuronal System Reactome Pathways 2024 1.0 null GSE166944_0_v_2_eif4b_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.09024 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATP1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26008 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.851101 Leishmania infection Reactome Pathways 2024 1.0 null voltage-gated calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.945 TPSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79168 lateral part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08833 CRCGN014_HEPG2_3H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1699 G alpha (i) signalling events Reactome Pathways 2014 1.0 null Cerebellum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56793 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 46.1438 CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4508 BRD-K93956318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06218 BRD-K45394633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0599 JHESOAD1 CCLE Cell Line Gene Expression Profiles -1.0 -1.56738 COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.908607 Perturb_1267_KD_Prmt7_SRP279352 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.13248 Metabolic disorders of biological oxidation enzymes Reactome Pathways 2014 1.0 null stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10539 Perturb_2980_KD_Mbnl1/Mbnl2_SRP057123 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.50013 MDAMB453 DepMap CRISPR Gene Dependency 1.0 7.02865 CME1 DepMap CRISPR Gene Dependency 1.0 2.05833 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K93391478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15882 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21848 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.828518 PMC11295044-pnas.2403331121.sapp.pdf-33-ZMAT1_ZMAT1 Rummagene Transcription Factor Associations 2026 1.0 null KP3 CCLE Cell Line Gene CNV Profiles 1.0 1.5829 ASCL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82826 ADRBK2 Pathway Commons Protein-Protein Interactions 1.0 null WNT7A Pathway Commons Protein-Protein Interactions 1.0 null POU5F1-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08644 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14387 CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.68938 ZNF785 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27319 WASF2 Pathway Commons Protein-Protein Interactions 1.0 null HS698T CCLE Cell Line Gene Expression Profiles -1.0 -2.31462 peripheral nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.265038 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68391 Lateral hypothalamic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18086 G beta:gamma signalling through PI3Kgamma Reactome Pathways 2014 1.0 null hmc1 HPA Cell Line Gene Expression Profiles -1.0 -1.45928 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4228-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FCGR2A Pathway Commons Protein-Protein Interactions 1.0 null POU5F1-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nafcillin-4103 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null medial septal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22877 H3K27me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE175787_5_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null KMH2 CCLE Cell Line Gene Expression Profiles -1.0 -2.78223 SEC14L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69977 SPAG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60593 CREBBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30069 BRD-K70895130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35426 Anxiety Disorders CTD Gene-Disease Associations 1.0 1.27101 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2155 alar part of terminal hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27667 response to peptide GO Biological Process Annotations 2015 1.0 null neuron part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.070779 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.923205 SOX9 ChEA Transcription Factor Targets 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Metabolism Reactome Pathways 2024 1.0 null SRY-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null WNT9B Pathway Commons Protein-Protein Interactions 1.0 null Perturb_15050_KO_A2AR_SRP251523 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.34604 Perturb_13457_OE_Smn1_SRP366489 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.42599 Class B/2 (Secretin family receptors) Reactome Pathways 2024 1.0 null Chemokine signaling pathway KEGG Pathways 2026 1.0 null BRD-K76616863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.705 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11941 RETREG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75341 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08587 Perturb_4989_KO_Ythdc1_SRP212677 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.92767 Perturb_5857_KD_Apc_SRP076100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.31355 GSE200673,GSE200691_1_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WNT3A Pathway Commons Protein-Protein Interactions 1.0 null orbital frontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.877214 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16893 ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0201 CACNA1C Pathway Commons Protein-Protein Interactions 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.930445 BRD-K68683482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27844 LN18 CCLE Cell Line Gene CNV Profiles 1.0 2.02826 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12145 Focal adhesion PI3K Akt mTOR signaling WikiPathways Pathways 2024 1.0 null Perturb_13071_KO_Cry2_SRP091906 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.96921 MFSD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44846 PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR Rummagene Transcription Factor Associations 2026 1.0 null FGF20 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sensory cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.499615 ENTPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4305 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13178 Perturb_11505_KO_Brg1_SRP271459 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.29595 OLIG2 ChEA Transcription Factor Targets 1.0 null KLF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 114.035 response to peptide hormone GO Biological Process Annotations 2015 1.0 null dentatorubral-pallidoluysian atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.083 BRD-K26399271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36803 CAL148 CCLE Cell Line Gene Expression Profiles 1.0 1.36042 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.7716 LCOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76563 carcinine-4809 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null semustine-7540 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52997 mRNA_RXRA_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10453 Elytron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.501 BRD-K70343553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2044 BRD-K34761198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4346 aminohippuric acid-6453 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_2609_KD_CLIP1_SRP212229 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.67022 Perturb_14569_KO_Got2_SRP348541 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.14655 BRD-K27352194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95716 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052234 MFSD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66015 NDUFB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47722 WNT5A Pathway Commons Protein-Protein Interactions 1.0 null Perturb_13628_OE_Fosl2_SRP200662 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.06131 H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RHBDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50831 response to organic substance GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.34054 imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Musculoskeletal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.078 NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7541 BRD-K49981566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37912 dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.224913 CPNE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46492 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.29683 BRD4_01_119 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.35 LIAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59108 hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02423 cinchonine-4107 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GRPEL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96692 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27869 AKT2 Pathway Commons Protein-Protein Interactions 1.0 null ZNF449 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.945 BRD-K74677971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38593 ChIP_K27me3_17603471_mouseMEF ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE230656_0_v_1_gsdmd_mouse RummaGEO Gene Perturbation Signatures 1.0 null Parabrachial nucleus, lateral division, external lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06477 EGR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.8505 VAV3 Pathway Commons Protein-Protein Interactions 1.0 null Peptide hormone metabolism Reactome Pathways 2014 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.6158 CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3839 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24043 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null K562 BioGPS Cell Line Gene Expression Profiles 1.0 0.841225 molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71197 C1orf210 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45569 NCIH1048 CCLE Cell Line Gene CNV Profiles -1.0 -1.95092 SINHCAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77418 CRCGN014_HEPG2_3H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.19145 membrane GO Cellular Component Annotations 2015 1.0 null nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.084442 cellular response to glucagon stimulus GO Biological Process Annotations 2015 1.0 null ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06832 GSE216147_2_v_1_rbm20_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K08629159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10167 NKX6-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02165 GSE135514_8_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE101112_0_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11914 GNB2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K03937692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90061 protein binding GO Molecular Function Annotations 2015 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41116 SLC12A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77894 Supramammillary nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08833 primary motor cortex (area M1, area 4)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10808 PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9 Rummagene Transcription Factor Associations 2026 1.0 null nordihydroguaiaretic acid-5583 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.70288 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47893 BRD-K40143134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66129 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.294 ELOA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96876 CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.52668 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.17594 BRD-K49666076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01853 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1143 GDSC Cell Line Gene Expression Profiles -1.0 -1.51954 OB outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08833 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6907-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFHX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53867 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.92031 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.38582 Climbing fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.519 Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03385 BRD-K55763052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44456 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27994 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.906779 juxtacommissural pretectal domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25937 LCK Pathway Commons Protein-Protein Interactions 1.0 null GRK4 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17819_KO_Bmal1_SRP260650 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.50361 CRCGN016_MCF10A.TP53.M_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.48956 APOBEC3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0602 CALCOCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39741 FEV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11824 CRCGN009_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.92373 ZNF235 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43123 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 CRCGN016_MCF10A.TP53.M_24H:L11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.75003 Perturb_11960_KD_RAD6B_SRP258673 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.21117 sisomicin-2853 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ergocalciferol-3304 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null clozapine_mus musculus_gpl339_gse6467 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839594 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF658 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62414 BRD-K89471250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52918 BRD-K68149575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05908 Perturb_16084_KO_Nfya_SRP270915 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.62114 BRD-K33979719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69375 CRCGN013_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51967 hexamethonium bromide-4965 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9944 mantle zone of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01943 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCCPAN2 DepMap CRISPR Gene Dependency 1.0 2.4288 CACNA1A Pathway Commons Protein-Protein Interactions 1.0 null (+/-)-catechin-3351 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCIH727 CCLE Cell Line Gene CNV Profiles 1.0 1.5547 brinzolamide-3230 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08476323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01155 TLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33306 ZNF394 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49514 TBX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91282 GSE236511_1_v_0_ngfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ABTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98082 GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21088 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.32655 Sensory cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.661 cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5361 beta-catenin independent WNT signaling Reactome Pathways 2014 1.0 null PMC5054603__F3 PFOCR Pathway Figure Associations 2024 1.0 null H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.2351 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38679 Culmen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67878 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.879035 BRD-K78249980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1854 ZBTB7A ENCODE Transcription Factor Targets 1.0 null Nasal cavity TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.2 ACHN CCLE Cell Line Gene CNV Profiles 1.0 1.89377 lateral (dentate) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10769 Perturb_13589_KD_Rbm39_SRP360787 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.49692 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.84808 Integration of energy metabolism Reactome Pathways 2014 1.0 null H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE151494_8_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.847853 CRCGN016_MCF10A.WT.HP_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26505 GSE258991_5_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Connective tissue disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.078 Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37453 TOP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22237 ATF2 ENCODE Transcription Factor Targets 1.0 null Perturb_12895_KO_NCOR1_SRP319377 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.69044 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69753 Varicosity DisGeNET Gene-Disease Associations 1.0 null Serotonergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.513 ELF1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.17005 MSANTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17405 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.256902 mantle zone of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28561 Bone disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.078 CD164 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9396 SOX17 JASPAR Predicted Transcription Factor Targets 1.0 null PLCG1 Pathway Commons Protein-Protein Interactions 1.0 null HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.2042 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SJCRH30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.53927 Palpus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.372 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null Dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02516 levamisole-2257 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DLG4 Hub Proteins Protein-Protein Interactions 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.841527 extrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 CALU6 DepMap CRISPR Gene Dependency 1.0 3.11383 GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GIPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77349 BRD-K69751974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07807 Brush cell (Tuft cell)_Small intestine_Mouse CellMarker Gene-Cell Type Associations 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50830147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43006 Lobules IV-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67787 CRCGN013_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.78358 HT CCLE Cell Line Gene Expression Profiles 1.0 2.00015 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.1829 CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4546 CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7898 Crus 2, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64235 BRD-K02078984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65433 regulation of cellular process GO Biological Process Annotations 2015 1.0 null Familial periodic paralysis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.124 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_27_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PI3K Akt signaling WikiPathways Pathways 2024 1.0 null Theca cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.796 HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.94695 BRD-K10157835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5488 GATA1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31113 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13090434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70747 G alpha (z) signalling events Reactome Pathways 2024 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_7351_KD_SFPQ_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.11052 Mean reticulocyte volume GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.92218 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.83418 Incretin synthesis, secretion, and inactivation Reactome Pathways 2024 1.0 null septal organ BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.35016 CCDC152 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61193 mediodorsal nucleus of thalamus_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16239 GATA1_G1E-ER4_mm9_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3527_KD_EIF4A3_SRP385300 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.71208 Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.4887 NCI-H2227 GDSC Cell Line Gene Expression Profiles 1.0 1.55075 inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.943858 Anti-inflammatory response favouring Leishmania parasite infection Reactome Pathways 2024 1.0 null Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.83424 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 BRD-K28983467 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09108 SLC27A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2516 GABA receptor activation Reactome Pathways 2024 1.0 null H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Protein folding Reactome Pathways 2024 1.0 null MBNL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91583 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32016 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73736 RAB35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78835 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78003637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.09728 BRD-K69594935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35752 periventricular stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.095 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHTF18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5671 FZD3 Pathway Commons Protein-Protein Interactions 1.0 null DDIT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75242 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_76_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44068 cytoplasmic side of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.00975 GSE80446_0_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures 1.0 null pivmecillinam-3535 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MFE-280 GDSC Cell Line Gene Expression Profiles -1.0 -1.88352 sensory perception GO Biological Process Annotations 2015 1.0 null GSE88819_6_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Parabrachial nucleus, lateral division, dorsal lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16792 mantle zone of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24273 superficial stratum of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5945 terminal hypothalamus (rostral hypothalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28561 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE92457_9_v_12_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Paramedian lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79533 SMARCAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66854 mantle zone of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33327 SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.539 Olfactory receptor neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.819 fulvestrant-7534 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53761 BRD-K89760040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0981 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00487 GSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38134 MIX23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66186 hsa-miR-340 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 Perturb_16667_KO_Tet2/Tet3_SRP056118 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.38129 Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Reactome Pathways 2014 1.0 null PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.914295 BRD-K22988729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01382 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1986 Perturb_16969_KD_AJUBA_SRP253076 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.29961 SETDB1_KO_GSE40296_7_mouse_brain (telencephalon) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PKNOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01818 Eye-retinal bipolar neuron Tabula Sapiens Gene-Cell Associations 1.0 1.63771 NCIH460 DepMap CRISPR Gene Dependency 1.0 2.67407 CRCGN016_MCF10A.WT.HP_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9724 benzocaine-2822 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE174735_4_v_3_il22_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.5203 GSE188870,GSE188871_0_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null energy reserve metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K69780027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30981 BRD-K11487484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63868 BRD-K97962579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96642 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12687 FAM86B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20864 ZNF276 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92773 Presynaptic function of Kainate receptors Reactome Pathways 2014 1.0 null KMS26 CCLE Cell Line Gene CNV Profiles 1.0 1.33812 macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-82-IRX3_IRX3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SYTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16502 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LCORL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23731 GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 88.7446 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26304 BRD-K72435943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03136 Main olfactory bulb, granule layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76111 scopolamine-4803 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Asthma_Epithelial Cell_GSE4302 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.17673 MYB ENCODE Transcription Factor Targets 1.0 null SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876945 Cholinergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.235 Perturb_13896_KO_TLR3/MYD88_SRP332441 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.9539 SKLMS1 CCLE Cell Line Gene Expression Profiles -1.0 -1.54961 ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.2877 WNT10B Pathway Commons Protein-Protein Interactions 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.863793 CHAGOK1 CCLE Cell Line Gene Expression Profiles 1.0 1.57528 CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.17861 H4 DepMap CRISPR Gene Dependency 1.0 2.04116 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.06177 GCGR Pathway Commons Protein-Protein Interactions 1.0 null canrenoic acid-2228 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TTC709 DepMap CRISPR Gene Dependency 1.0 2.5359 KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.4395 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.841819 SRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12231 Primary hematopoietic stem cells G-CSF-mobilized Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.62973 BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6401 CRCGN011_HEPG2_24H:C08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2217 Perturb_5217_KO_Rnf2/Bap1_SRP162521 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.92648 CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0632 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4918 interacts GeneRIF Biological Term Annotations 1.0 null BRD-K55220938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1997 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.930771 NCIH2066 CCLE Cell Line Gene CNV Profiles -1.0 -2.28084 Perturb_2903_KD_Acvr1c_SRP117681 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.58359 Anteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0425 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49H-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83248 pregnenolone-4802 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null amiprilose-3339 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0014 Thymic stromal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.82 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.825987 BRD-K19435356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32804 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11167 Perturb_6856_KD_CNOT1_SRP287793 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.71981 GSE88819_3_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.970614 G alpha (q) signalling events Reactome Pathways 2014 1.0 null NFYB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86468 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.56648 GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null GPANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34049 VAV1 Pathway Commons Protein-Protein Interactions 1.0 null mantle zone of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19632 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0027 MELJUSO DepMap CRISPR Gene Dependency 1.0 3.32437 Lung adenocarcinoma_LUAD_TCGA-75-7030-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAF-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PLAGL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.1591 alpha-ergocryptine-3900 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4283 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 phospholipase c-activating g-protein coupled receptor signaling pathway GO Biological Process Annotations 2015 1.0 null A3-KAW COSMIC Cell Line Gene Mutation Profiles 1.0 null SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39936 POLR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7009 Perturb_3848_KD_lncRNAAK096729_SRP192850 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -18.2007 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Reactome Pathways 2024 1.0 null FGF4 Pathway Commons Protein-Protein Interactions 1.0 null ethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15275 cortical cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.386979 GATA3-20176728-TSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K34256721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.71499 Perturb_13266_KO_chr3_SRP162484 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862691 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70205 CACNA1B Pathway Commons Protein-Protein Interactions 1.0 null Hemispheric regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66412 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE89767_2_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ChIP_ESRRB_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K09721398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72981 CENPU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05935 17616640-TableS3 GeneSigDB Published Gene Signatures 1.0 null MEK_INHIBITION_GDS5029_279_human_SW480 KRAS-mutant colorectal cancer cell line - 16hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null layer 2 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50623 MDAMB361 DepMap CRISPR Gene Dependency 1.0 4.47771 g-protein coupled receptor signaling pathway GO Biological Process Annotations 2015 1.0 null GPER1 signaling Reactome Pathways 2024 1.0 null BRD-K73658839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14688 STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE188869,GSE188871_1_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null VAV2 Pathway Commons Protein-Protein Interactions 1.0 null 496100364_TCx_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02244 Signal amplification Reactome Pathways 2024 1.0 null GSE146894_3_v_8_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null A704 CCLE Cell Line Gene CNV Profiles 1.0 1.63996 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54787 CYFIP2 Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.12377 metacycline-4143 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K28853245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24924 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06713 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.05866 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_46_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Regulation of insulin secretion Reactome Pathways 2014 1.0 null midodrine-2250 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25534 Aquaporin-mediated transport Reactome Pathways 2024 1.0 null intermediate stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08964 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EDRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84817 Side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.108 Mitotic spindle midzone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.992 FGF3 Pathway Commons Protein-Protein Interactions 1.0 null TOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00749 BRD-K00938872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10677 GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K62659610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52213 terminal subparaventricular area of THyA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70681 rhombomere 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41818 GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51873 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.59016 intermediate part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43054 POU5F1 ChEA Transcription Factor Targets 1.0 null substantia innominata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.901927 BRD-K57404319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11821 59M CCLE Cell Line Gene Expression Profiles -1.0 -1.54687 CMAH_KO_GDS4200_114_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19984 Extrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Perturb_12500_KD_HAPSTR1/HUWE1_SRP377309 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.89597 ZNF619 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05471 Perturb_7180_KO_TrEx_SRP163035 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.2204 heterotrimeric g-protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GSE157383_0_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21788 MACF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53115 Perturb_7739_KD_PCF11_SRP175016 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.0827 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.96772 Perturb_16495_KD_RBM39_SRP301121 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 MTA3 ENCODE Transcription Factor Targets 1.0 null BRD-K78288885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12316 rhein LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11074 Extrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.731 Class B/2 (Secretin family receptors) Reactome Pathways 2014 1.0 null paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1129 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 Perturb_12903_KD_ER_SRP313175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.80843 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.47154 GSE202933_1_v_0_ugt2b28_human RummaGEO Gene Perturbation Signatures -1.0 null TP53I11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14801 PCDHB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50949 increased circulating glucose level IMPC Knockout Mouse Phenotypes 1.0 null BRD-K40251180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52283 ARHGAP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57361 HT29 BioGPS Cell Line Gene Expression Profiles 1.0 1.01474 GSE195568_2_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_0Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.3304 JMURTK2 DepMap CRISPR Gene Dependency 1.0 2.92362 G protein-coupled GABA receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.683 CRCGN017_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9765 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_74_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21 THRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71734 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21599 timolol-5280 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null mRNA_ASCL1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Cytoplasmic side of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 KURAMOCHI GDSC Cell Line Gene Expression Profiles -1.0 -1.94167 BRD-K99939085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57936 Hypothalamic lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88462 Lung adenocarcinoma_LUAD_TCGA-44-5645-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIN7B Pathway Commons Protein-Protein Interactions 1.0 null G-protein activation Reactome Pathways 2014 1.0 null BRD-K96149826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12167 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_18442_KD_YAP1/WWTR1_SRP303519 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.21242 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.941657 BRD-K54250149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06165 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null NKX2-5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null OB granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39661 Folium-tuber vermis (VII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77189 F11R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0751 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.41846 RT4 CCLE Cell Line Gene CNV Profiles -1.0 -1.63204 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051101 SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59797 HSFX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21444 STEAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79738 Copula pyramidis, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36693 CREB1_01_194 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.54999 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54146 Perturb_5266_KD_neg_SRP331021 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.46311 Bipolar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.479 KIF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.64892 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MIR140_OE_GDS3461_575_mouse_C3H10T1/2 fibroblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10120_KO_RNH1_ERP021688 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.0564 trimipramine-3342 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MMADHC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86918 EPHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38867 HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.73339 G Protein Signaling Pathways(Homo sapiens) WikiPathways Pathways 2014 1.0 null OCT4-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null medial (main) part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13549 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.36675 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE115363_2_v_0_esrrb_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5361 TSSK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03578 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Perturb_14118_KD_RPS6KB2_SRP187713 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.48724 Neuronal System Reactome Pathways 2014 1.0 null CRCGN014_HEPG2_24H:A03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.03244 CRCGN010_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4534 nadolol-4139 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.51727 PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06198 PRPSAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29884 PMC11906354-41588_2025_2087_MOESM4_ESM.xlsx-ST12-Unnamed_3_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15630_KD_Ctnnb1_SRP130920 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.76934 Hypothalamus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.854525 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.907505 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:P17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20789 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE10 CCLE Cell Line Gene Expression Profiles 1.0 1.78053 BRD-K28811650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44856 PLEKHO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92628 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RL CCLE Cell Line Gene Expression Profiles 1.0 1.38683 superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2679 outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.850302 BRD-K10638173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.46229 Relaxin signaling pathway KEGG Pathways 2026 1.0 null Perturb_5158_KD_Zic3_SRP046299 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.8574 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26559 eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057788 BRD-K67194214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.19794 Perturb_5282_KO_Ddx6_SRP137728 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.94079 MYCN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5298 BRD-K19474742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81947 BRD-K57059449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53428 AGBL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25004 BRD-K96839404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68712 RHOQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70372 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40893 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.96482 BRD-K80332123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23074 GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.502 Perturb_2610_KD_PCF11_SRP212229 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.36863 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849102 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.938504 Opioid Signalling Reactome Pathways 2014 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.915535 BRD-K56716645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44955 Perturb_14485_OE_Tp73_SRP134969 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.639 single-organism cellular process GO Biological Process Annotations 2015 1.0 null CXADR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77458 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.3462 icSARA deltaORF6_3Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.32012 BRD-K34318928 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13104 chlorogenic acid-4142 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null outer CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4575 Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF589 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51569 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13042 Perturb_3366_KO_Tet2/Tet3_SRP056118 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.93065 synapse part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.236324 Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3678 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.47075 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.52004 SNU175 CCLE Cell Line Gene Expression Profiles 1.0 1.63808 A375SKINCJ1 DepMap CRISPR Gene Dependency 1.0 8.2892 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14917 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.14009 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null REX1BD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22738 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54006 G alpha (z) signalling events Reactome Pathways 2014 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53061 SYK Pathway Commons Protein-Protein Interactions 1.0 null GSE206226_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_13080_KO_Cry2_SRP091906 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.61887 GSE214514_1_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14602 Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80877725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02958 BRD-K75983763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59854 DLG1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BUB1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15915 rifampicin-4126 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 4.1022 oxolamine-3344 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hemostasis Reactome Pathways 2014 1.0 null Perturb_15670_KD_Sf3a1_SRP043160 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.21583 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 87.4575 Perturb_2229_KO_Rela_ERP122918 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.44415 CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05265 Metabolism of proteins Reactome Pathways 2024 1.0 null ZNF500 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88737 NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24776 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_69_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_13559_KD_Kdm1a_SRP105108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.97609 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05619 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2756 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.272 Atrophy CTD Gene-Disease Associations 1.0 1.02933 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.918631 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25708 Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03693 Fetallung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.885175 primary auditory cortex (core)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.977217 probenecid-2825 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7247 STK31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2712 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34466 GSE130246_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_4985_KO_Ythdc1_SRP212677 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.09445 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.916595 CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.81565 GSE224096_3_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null GAB2 Pathway Commons Protein-Protein Interactions 1.0 null RNF38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90731 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40642 duodenum HPA Tissue Protein Expression Profiles 1.0 1.26996 PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Perturb_3443_KO_Acsl6_SRP321472 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.65941 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.907981 BRD-K31805261 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18075 H3K27me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE120336_1_v_2_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K28510065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13362 NCIH23 DepMap CRISPR Gene Dependency 1.0 3.02335 KLF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.0199 U87MG CCLE Cell Line Gene CNV Profiles -1.0 -1.34681 SP3_01_290 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.14423 RPE1SS51 DepMap CRISPR Gene Dependency 1.0 4.26072 ERBB2_knockdown_238_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.33291 Main olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24273 TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null signal transducer activity GO Molecular Function Annotations 2015 1.0 null BRD-K61144709 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.95005 GSDMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02334 TMCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09184 INKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84452 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38679 G beta:gamma signalling through CDC42 Reactome Pathways 2024 1.0 null mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.90942 single-organism process GO Biological Process Annotations 2015 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.71378 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45544 dorsal nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08985 CUX1 Pathway Commons Protein-Protein Interactions 1.0 null CEP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61051 Perturb_11511_KD_Fbxo22_SRP170074 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.87445 ChIP_H3K9me3_19884255_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02125 KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.1526 Cytoplasmic side of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 BRD-K99119142 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18604 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sensillum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.56 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.859152 Ovarian steroidogenic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.807 PITX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81416 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63793 Perturb_14052_OE_NFIB_SRP281947 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.46467 PPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57542 Wnt signaling pathway PANTHER Pathways 1.0 null BRD-K73994499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.25091 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.828426 SOX9-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32838 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Reactome Pathways 2024 1.0 null ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 107.972 CRCGN015_MCF10A_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.72896 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null isthmus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35145 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Congenital stationary night blindness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.433 BRD-K75220555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23537 hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.223 KS1 CCLE Cell Line Gene CNV Profiles -1.0 -2.14413 Perturb_14487_KO_Trp53_DRP003641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.62514 Olfactory organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.507 CRCGN014_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.422 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4ND-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64732 Heterotrimeric G-protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Perturb_4233_KO_Pnky_SRP187847 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.14999 MEL-JUSO GDSC Cell Line Gene Expression Profiles -1.0 -1.49318 Thymic medulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.36827 CRCGN015_MCF10A_48H:H22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14033 cerebellar cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.48461 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16148 GTPase complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 FZD2 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7867 Intrinsic component of periplasmic side of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.468 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K19672435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30853 SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01036 PGAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91853 cellular response to oxygen-containing compound GO Biological Process Annotations 2015 1.0 null CD3G Pathway Commons Protein-Protein Interactions 1.0 null OVISE CCLE Cell Line Gene Expression Profiles 1.0 1.47579 G beta:gamma signalling through BTK Reactome Pathways 2024 1.0 null CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0744 CRCGN015_MCF10A.TP53.M_24H:O22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.387 BRD-K61491580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.589 hsa-miR-3945 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 ncoa_22072566_ly2_lof_human_gpl570_gds4095 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.185852 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.082724 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20888 CRCGN017_MCF10A.WT.HP_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6856 ADORA2B mediated anti-inflammatory cytokines production Reactome Pathways 2024 1.0 null HASPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68982 megestrol-6468 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null multicellular organismal process GO Biological Process Annotations 2015 1.0 null HUH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.78219 CLCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72177 mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04881 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.848901 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Anterior cingulate area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32334 CLASP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81809 BRD-K26024910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29185 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42036 BTK Pathway Commons Protein-Protein Interactions 1.0 null BRD-K97330035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36901 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_41_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.504 PMC9882185-media-4.xlsx-Neuron_KD-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K72602058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04742 preweaning lethality, incomplete penetrance MGI Mouse Phenotype Associations 2023 1.0 null PMC12693071-NIHMS2120882-supplement-8.xlsx-Sheet1-scWGS_analysis_of_the_M486_AR_model_AR-specific_or_-enriched_CNV_genes_involved_in_apoptosis_immune_regulation_and_or_known_ICI_resistance_pathways_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE139966_1_v_2_figla_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15281 CACNA1D Pathway Commons Protein-Protein Interactions 1.0 null dorsal part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20998 ITPR1 Pathway Commons Protein-Protein Interactions 1.0 null Main olfactory bulb, inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38543 PMC10273062-JCMM-27-1708-s001.xlsx-Sheet_1-BRCA_AND_CESC_AND_UCEC_NOT_UCS_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null TIMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45018 SAR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.113 ChIP_POU5F1_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null FGF10 Pathway Commons Protein-Protein Interactions 1.0 null Extra-nuclear estrogen signaling Reactome Pathways 2024 1.0 null BIN67 DepMap CRISPR Gene Dependency 1.0 2.84626 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100439_PCx_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00697 pentoxifylline-2290 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_5128_KD_Med4_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.94064 ZNF501 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56112 LNCaP-Clone-FGC GDSC Cell Line Gene Expression Profiles 1.0 1.62665 GSE88819_3_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39121 BRD-K37506332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23769 Mean corpuscular hemoglobin GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.35229 infertility MGI Mouse Phenotype Associations 2023 1.0 null CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.94225 ARH77 DepMap CRISPR Gene Dependency 1.0 2.57154 Signal Transduction Reactome Pathways 2024 1.0 null VMRCRCW CCLE Cell Line Gene CNV Profiles 1.0 1.60479 stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07572 Human immunodeficiency virus 1 infection KEGG Pathways 2026 1.0 null Lobules IV-V, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66412 CRCGN017_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7576 perimammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37453 Cancer of the testis_Testis_GSE1818 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.54269 ADRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08746 GPSM1 Pathway Commons Protein-Protein Interactions 1.0 null binding GO Molecular Function Annotations 2015 1.0 null PMC7605384__F6 PFOCR Pathway Figure Associations 2024 1.0 null Neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null BRD-K80724972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40591 IGLC1 Pathway Commons Protein-Protein Interactions 1.0 null MYB_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49G-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERG_01_17 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59561 BRD-K00231307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25228 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100290_PCx_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29276 H3K27me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE173201_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840925 GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K36539857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10984 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054833 CingulateCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16316 BRD-K61039403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33045 mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.958678 IGHG1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN016_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.34324 CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1389 pioglitazone-7506 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Anterior cingulate area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44278 Purkinje cell layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69365 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94540403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00834 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.12915 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.8572 krt7_21596846_megakaryocyte_progenitor_bone_marrow_lof_mouse_gpl6105_gse24969 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.244895 BRD-K61335814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25096 GSE43041,GSE43044_0_v_1_ldb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.855059 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NUPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57271 BRD-K12665145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73955 CRCGN016_MCF10A.TP53.M_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45828 GSE149760_3_v_5_elof1_human RummaGEO Gene Perturbation Signatures 1.0 null mRNA_REST_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51679 CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.23782 Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.0929 BRD-K58762810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98328 CA SKI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25675 BRD-K82102697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75829 colon GTEx Tissue Gene Expression Profiles 1.0 0.993579 Cholinergic synapse KEGG Pathways 2026 1.0 null Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PANTHER Pathways 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.918169 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53287 N-acetyl-L-aspartic acid-4125 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FZD9 Pathway Commons Protein-Protein Interactions 1.0 null tribenoside-5429 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IC-86621-7543 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7 CCLE Cell Line Gene Expression Profiles 1.0 2.14783 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.3022 Activation of GABAB receptors Reactome Pathways 2024 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20058 dorsolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839845 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.997763 NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2369 PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ZNF217_ER-Nearest_Ensembl_ZNF217 Rummagene Transcription Factor Associations 2026 1.0 null PMC2801177__F3 PFOCR Pathway Figure Associations 2023 1.0 null RPAIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53795 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.959684 Polysomal ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.713 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.30795 Perturb_13279_KO_Ythdf1_SRP254797 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.16125 UBTF ENCODE Transcription Factor Targets 1.0 null CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.44718 GABA B receptor activation Reactome Pathways 2024 1.0 null 17660535-TableS4b GeneSigDB Published Gene Signatures 1.0 null LIG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68769 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.997738 GSE210101,GSE210114_11_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null propidium iodide-6104 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GNB5 Pathway Commons Protein-Protein Interactions 1.0 null LCP2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K25600773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10926 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.890351 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45553 presynaptic cytoskeletal matrix assembled at active zones COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.692955 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_57_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.922389 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma membrane part GO Cellular Component Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01081 fosfosal-3336 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K93148720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.72317 GSE148692,GSE148695_7_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NME2 Pathway Commons Protein-Protein Interactions 1.0 null GSE212299_2_v_1_abi3_mouse RummaGEO Gene Perturbation Signatures -1.0 null small kidney MGI Mouse Phenotype Associations 2023 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.464 MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.06568 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42707 ESRRB ChEA Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EK-01A-22R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04858 Vasopressin regulates renal water homeostasis via Aquaporins Reactome Pathways 2014 1.0 null GPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62564 LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63545 Perception HuGE Navigator Gene-Phenotype Associations 1.0 null Leishmania parasite growth and survival Reactome Pathways 2024 1.0 null Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18456 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44938 Transmembrane transport of small molecules Reactome Pathways 2014 1.0 null Perturb_16604_KO_Phb_SRP229743 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.13919 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16663 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.959474 response to stimulus GO Biological Process Annotations 2015 1.0 null GAB1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_6176_KO_Opn1lw/Ep300_SRP201904 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.40615 H4K20me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Signaling by Nuclear Receptors Reactome Pathways 2024 1.0 null GATA1_G1E-ER4_mm9_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.952242 response to oxygen-containing compound GO Biological Process Annotations 2015 1.0 null MLKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83276 Cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.104 Koelliker-Fuse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02505 Purkinje cell layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50727 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06198 Perturb_271_KO_ADIRFAS786_SRP366780 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.54948 Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31606237 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.98689 GSE235644_1_v_0_fasn_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brush cell (Tuft cell)_Trachea_Mouse CellMarker Gene-Cell Type Associations 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.948473 SNU-423 GDSC Cell Line Gene Expression Profiles -1.0 -1.42564 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112763,GSE112767_4_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZDHHC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62019 NALM-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34239 cellular metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_3642_KO_DNMT1_ERP115567 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.79256 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null mantle zone of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61298 GATA1_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.889054 BRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00148 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.28647 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64407 BRD-K85567359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5314 TOPORS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70566 cell cortex part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.328332 Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:D09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.80742 Lobule II, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32648 BRD-K77624847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58292 BRD-K39863565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48665 PMC6756575__F4 PFOCR Pathway Figure Associations 2024 1.0 null MAN2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45807 Perturb_5875_KD_Apc_SRP076100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.56533 SNX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88386 CRCGN014_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.53764 UBE2S CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00151 CD68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95111 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 155.436 CH25H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24383 BRD-K25710391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56712 BRD-K07350528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21039 posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.852384 G alpha (s) signalling events Reactome Pathways 2014 1.0 null Perturb_13217_KO_Mettl3_SRP109093 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.37607 BRD-K32485819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46911 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4603_KO_Mst_SRP246200 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.50667 GSE127790_13_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MEF2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71949 Simple lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75657 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.930445 HS766T DepMap CRISPR Gene Dependency 1.0 2.50097 Transport of small molecules Reactome Pathways 2024 1.0 null HLA-DOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84828 Beta-catenin independent WNT signaling Reactome Pathways 2024 1.0 null CRCGN017_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02838 CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.113 CRCGN010_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8241 MADD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20274 CHD1 ENCODE Transcription Factor Targets 1.0 null Perturb_12501_KD_HUWE1_SRP377309 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.59814 L-type voltage-gated calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.166 single-multicellular organism process GO Biological Process Annotations 2015 1.0 null Copula pyramidis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3248 PBX3 ENCODE Transcription Factor Targets 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883635 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054691 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.65176 superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02238 PMC5054603__F3 PFOCR Pathway Figure Associations 2023 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02586 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48455 PMC8063444__F5 PFOCR Pathway Figure Associations 2023 1.0 null Cancer pathways WikiPathways Pathways 2024 1.0 null TIGD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75784 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.40361 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.87283 mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20188 Perturb_5869_KD_Cpsf7_SRP336206 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.1691 Perturb_13108_KO_Mbnl1/Mbnl2_SRP045573 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.62261 496100648_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00006 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.984974 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.82401 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12486 Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14081 GSE132694,GSE132717_0_v_2_meis1_human RummaGEO Gene Perturbation Signatures -1.0 null heterotrimeric G-protein complex GO Cellular Component Annotations 2025 1.0 null Perturb_3445_OE_Sca17_SRP248035 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.20767 EZH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21987 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.44952 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34647 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0506 BRD-K39584933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52344 probucol-3223 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.4566 DSH1 GDSC Cell Line Gene Expression Profiles -1.0 -2.19614 Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53221607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.33913 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.892742 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05314 BRD-K05753543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14162 Respiratory mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.68 B2M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41528 GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.1732 ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.35143 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.15239 Perturb_8517_OE_CamkdeltaC_SRP287242 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.68368 SAMHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9993 Liver Diseases CTD Gene-Disease Associations 1.0 1.01701 Perturb_5124_KD_Med28_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.53056 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K85110576 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.61712 HCT15 BioGPS Cell Line Gene Expression Profiles -1.0 -2.5135 MXI1 ENCODE Transcription Factor Targets 1.0 null BRD-K38791044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25314 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05028 thioperamide-5270 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93728 Perturb_2835_KD_FOXA1_SRP313175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.7413 increased total body fat amount MGI Mouse Phenotype Associations 2023 1.0 null Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.25188 Perturb_5382_KO_Drosha_SRP169088 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.80821 GPCR downstream signalling Reactome Pathways 2024 1.0 null CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.82406 Giant cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.017 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-7643-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SF172 CCLE Cell Line Gene Expression Profiles -1.0 -1.50942 CRCGN013_HEPG2_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12078 body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33315 MICALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2718 IER3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24723 HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.54002 Side of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35728 sensory perception of taste GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.TP53.M_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21595 SCMCRM2 DepMap CRISPR Gene Dependency 1.0 2.07572 PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K84478344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23747 SCA1_Knock-in_GDS3544_562_mouse_Cerebellum - 12 Weeks GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN014_HEPG2_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40783 H3K27me3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K87080232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17449 Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.112 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EOMES_OE_GDS5077_65_human_RUES2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GABAergic synapse KEGG Pathways 2026 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.877789 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.92028 CRCGN016_MCF10A.WT.HP_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0274 CD74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36201 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35845 demeclocycline-4728 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G beta:gamma signalling through PLC beta Reactome Pathways 2024 1.0 null Cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 dentate (lateral) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43456 GNG4 Pathway Commons Protein-Protein Interactions 1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K53192330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69953 PAX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5817 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.1477 ZNF777 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3612 white matter of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41897 ABI1 Pathway Commons Protein-Protein Interactions 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47725 SLC8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5781 Anal plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.824 CASC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92679 FGF9 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K34604755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47511 CRCGN017_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6414 RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5757 ADI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70991 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06285 REH CCLE Cell Line Gene Expression Profiles -1.0 -2.17259 GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.02177 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K61494613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87826 STAT3-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Guanosine diphosphate HMDB Metabolites of Enzymes 1.0 null GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K16238077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07665 LRRC10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37977 HCC2279 CCLE Cell Line Gene Expression Profiles -1.0 -1.47849 Perturb_13179_KO_Mof_SRP060636 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.99187 ALVA31 BioGPS Cell Line Gene Expression Profiles 1.0 1.23501 CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MRM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67887 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37565 Activation of Kainate Receptors upon glutamate binding Reactome Pathways 2014 1.0 null Bladder GTEx Tissue Gene Expression Profiles 2023 1.0 6.37823 FBLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62591 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE139966_4_v_3_figla_mouse RummaGEO Gene Perturbation Signatures 1.0 null ADRA2A Pathway Commons Protein-Protein Interactions 1.0 null PMC6883365__F2 PFOCR Pathway Figure Associations 2024 1.0 null Sensory perception of taste Reactome Pathways 2024 1.0 null FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1332 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042151 Uterine Carcinosarcoma_UCS_TCGA-N9-A4PZ-01A-22R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91876603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19996 FGF22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71699 Anterior cingulate area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.36793 nifenazone-2285 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_5205_KO_Ddx6_SRP137727 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.7541 cerebellar nuclei of CbV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07058 perilemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14081 LDLR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43612 NKX2-5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CACNA2D2 Pathway Commons Protein-Protein Interactions 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042481 FLOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29663 CSKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52496 Perturb_757_KO_DNMT3B_SRP389363 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.22379 BRD-K27236794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89521 VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.19292 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cellular response to peptide GO Biological Process Annotations 2015 1.0 null BRD-K62555617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05692 NEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07556 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZSCAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79286 Cerebellum BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 extrinsic component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Perturb_4537_OE_TET3_SRP099074 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.74809 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04253 SMARCE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40559 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GNG10 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K07502463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21571 Photoreceptor outer segment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.911 SAP30 ENCODE Transcription Factor Targets 1.0 null parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70834 CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.76115 BRD-K73969016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18401 Platelet activation, signaling and aggregation Reactome Pathways 2014 1.0 null FGF19 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_5112_KD_Med10_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.41085 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051596 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K75806288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32249 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96854 DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56096 BRD-A53463743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32738 Dendrite terminus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.713 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ANKS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32524 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13072_KO_Cry2_SRP091906 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.18107 SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 91.5524 brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_53_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 niclosamide-4136 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hek293 HPA Cell Line Gene Expression Profiles 1.0 1.45123 mantle zone of PHyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43054 BRD-K24226959 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12744 Folium-tuber vermis (VII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77189 H3K27me3_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Platelet homeostasis Reactome Pathways 2024 1.0 null Potassium Channels Reactome Pathways 2024 1.0 null SRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33034 pramocaine-4368 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66486 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB-26923725-CHIP-SEQ-MESODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11016405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06619 H3K27me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.78772 LRF MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K61278167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20302 GNG11 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K24047785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.34372 BRD-K14309706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10197 Perturb_15694_OE_NOAT113026_SRP212748 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.11108 ERBB2_knockdown_233_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.93715 BRD-K97733472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9342 GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_1049_OE_SMARCD1_SRP269167 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.6135 GARNL3 Pathway Commons Protein-Protein Interactions 1.0 null Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58183 CD177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56563 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.883635 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.77048 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14944_KD_Nmnat1_SRP102079 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.76616 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37565 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.955723 BRD-K78866450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84742 UNC5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02985 MYO1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57953 CRCGN016_MCF10A.TP53.M_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14263 HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39323 LS411N DepMap CRISPR Gene Dependency 1.0 2.99177 Bam protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.468 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0237 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21607 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12687 FGFR2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K80782159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17235 BRD-K26954192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12927 olfactory bulb, principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23467 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46951 BRD-K32506050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1912 Hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.2927 Nasal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.707 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33679 ggamma13 GeneRIF Biological Term Annotations 1.0 null ITPR2 Pathway Commons Protein-Protein Interactions 1.0 null LAT Pathway Commons Protein-Protein Interactions 1.0 null VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0726 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null heptaminol-6015 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RMUGS DepMap CRISPR Gene Dependency 1.0 2.584 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A4BK-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13209_OE_Foxd3_SRP060372 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.65001 heterotrimeric g-protein complex GO Cellular Component Annotations 2015 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SEC14L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19325 NDUFS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18255 MAZ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 105.142 taste transduction KEGG Pathways 1.0 null PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.938504 SOX2 ChEA Transcription Factor Targets 1.0 null Claw TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.897 Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2024 Perturb_9399_KD_MYCN_SRP104120 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.01699 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K89476673 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24256 BRD-K74968522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65433 GSE189653,GSE203344_2_v_0_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZFP42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.50094 BRD-K61560971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12196 JAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46492 FZD5 Pathway Commons Protein-Protein Interactions 1.0 null Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77948 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25608 Perturb_13336_KD_Pou2f1_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.90024 mRNA_ATF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null IGKV4-1 Pathway Commons Protein-Protein Interactions 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.574 PACS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06337 KASUMI1 CCLE Cell Line Gene CNV Profiles -1.0 -1.62933 MALME3M CCLE Cell Line Gene CNV Profiles -1.0 -1.56399 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21964 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48022 BRD-K51779559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86116 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16829 SMARCA4-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.948547 BRD-K23361743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57501 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K02827191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71102 Platelet activation, signaling and aggregation Reactome Pathways 2024 1.0 null KLF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32199 ADRA2C Pathway Commons Protein-Protein Interactions 1.0 null Olfactory Signaling Pathway Reactome Pathways 2024 1.0 null DLG4 Pathway Commons Protein-Protein Interactions 1.0 null Epithelial generated pre-granulosa(EPG) cell_Fetal ovary_Mouse CellMarker Gene-Cell Type Associations 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.77042 BRD-K11188962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40397 BRD-K41025232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71409 BRD-K50941255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12809 GPSM2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K36176133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15331 GSE144231_3_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pathways in cancer KEGG Pathways 2026 1.0 null GSE244072_10_v_8_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null GRK7 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A.TP53.M_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8225 Perturb_10044_KD_EFTUD2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.69425 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051424 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null BRD-K03851221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06998 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13008 OGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35072 BRD-K86953192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.87036 Disease Reactome Pathways 2024 1.0 null NCIH1651 CCLE Cell Line Gene CNV Profiles 1.0 1.38759 BRD-K76609014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43546 GSE88819_3_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.552 BRD-K65054381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21164 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98504 generation of precursor metabolites and energy GO Biological Process Annotations 2015 1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.844625 Thalamus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 FZD7 Pathway Commons Protein-Protein Interactions 1.0 null N-phenylanthranilic acid-317 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20025 dorsal part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 POMGNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21545 ADP signalling through P2Y purinoceptor 12 Reactome Pathways 2014 1.0 null Perturb_7760_KD_RRP6/DIS3_SRP337423 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.78693 GSE210101,GSE210114_0_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K28982281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.21824 PHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94116 EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.3905 CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null etodolac-2254 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_7874_KD_H2A.Z.1_SRP259021 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.618 mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null FGF23 Pathway Commons Protein-Protein Interactions 1.0 null SNUC4 DepMap CRISPR Gene Dependency 1.0 2.20886 ISTMEL1 DepMap CRISPR Gene Dependency 1.0 2.66377 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC18A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45393 Platelet homeostasis Reactome Pathways 2014 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 FGF22 Pathway Commons Protein-Protein Interactions 1.0 null Lateral shield COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.043 H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K53443314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40167 SACS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94904 Extrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.878 GSE195568_2_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE173394_1_v_0_nfatc2_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79137 Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.346 GSE100217_2_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SH-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1806 CCLE Cell Line Gene Expression Profiles 1.0 1.45558 SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44762 Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AMIGO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45537 CRCGN012_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29698 RRH Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-8022-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61783 GSE165647_5_v_3_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PKDCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03562 GSE210101,GSE210114_5_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null mRNA_MYC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNG3 Pathway Commons Protein-Protein Interactions 1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.984635 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1558 BRD-K14449601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0375 mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54146 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX2-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K30214140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08367 CAL148 CCLE Cell Line Gene CNV Profiles 1.0 1.4414 BRD-K12555854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10057 BRD-K49424866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82132 GNB1 Pathway Commons Protein-Protein Interactions 1.0 null ADP signalling through P2Y purinoceptor 12 Reactome Pathways 2024 1.0 null SOGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68817 G alpha (12/13) signalling events Reactome Pathways 2014 1.0 null 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14189 Cellular responses to stimuli Reactome Pathways 2024 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_KLF4_18264089 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null RUNX1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RNASE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47218 BRD-K75330923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84711 15656903-Table1 GeneSigDB Published Gene Signatures 1.0 null BT483 CCLE Cell Line Gene Expression Profiles 1.0 1.99227 EFM19 CCLE Cell Line Gene Expression Profiles 1.0 1.70113 pdz GeneRIF Biological Term Annotations 1.0 null GSE197571_3_v_1_foxm1_human RummaGEO Gene Perturbation Signatures 1.0 null ranitidine-2251 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SOWAHC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02011 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_16710_KO_Phpt1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.33104 layer 2 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06505 neurological system process GO Biological Process Annotations 2015 1.0 null UFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4363 GSE124932_2_v_1_sarm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PTRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19992 Perturb_8347_KD_YY1_SRP286033 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.41767 G protein gated Potassium channels Reactome Pathways 2024 1.0 null Hereditary night blindness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.402 PMC7494657__F4 PFOCR Pathway Figure Associations 2024 1.0 null SMARCA4 ChEA Transcription Factor Targets 1.0 null Colo-678 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.84 hsa-miR-3151 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 ATF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16754 BRD-K05846874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79167 KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.2572 BRD-K48987279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08731 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.61718 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.942135 PCTP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42512 GPCR downstream signaling Reactome Pathways 2014 1.0 null BRD-K63858518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12426 bipolar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.937488 Perturb_10651_KD_Syncrip_SRP065017 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.91244 GSE236262_0_v_3_trim28_mouse RummaGEO Gene Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042305 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.56764 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8285 Metabolism of proteins Reactome Pathways 2014 1.0 null BRD-K27154831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80816 SPTBN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08884 496100375_FWM_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22163 G protein-coupled receptor dimeric complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.739 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null scopolamine N-oxide-5436 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.29581 Prostate adenocarcinoma_PRAD_TCGA-VN-A88O-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM208 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65989 BRD-K03662481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.57753 Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neuronal cell body membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.09 CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.04645 Thromboxane signalling through TP receptor Reactome Pathways 2024 1.0 null METTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96023 BRD-K06790927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25759 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Signal Transduction Reactome Pathways 2014 1.0 null CRCGN010_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10753 GSE218060_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null PRNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37635 STAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31086 Perturb_17316_KO_Tardbp_SRP321767 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.65852 Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF3 ChEA Transcription Factor Targets 1.0 null LRRK2_mutant_32_GDS4400 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.69291 Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29342 TMEM240 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53743 NCIH810 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3850_KD_AKAP12_SRP254561 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.34269 PEMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72622 SESN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93288 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27371 Incretin synthesis, secretion, and inactivation Reactome Pathways 2014 1.0 null posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09782 Opioid Signalling Reactome Pathways 2024 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cell cortex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.312597 Perturb_10320_KO_HDAC1/HDAC2_SRP255858 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 17.4318 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 165.673 CRCGN016_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02163 PANX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52951 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05095 Apelin signaling pathway KEGG Pathways 2026 1.0 null PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671 Rummagene Transcription Factor Associations 2026 1.0 null abnormal uterus morphology MGI Mouse Phenotype Associations 2023 1.0 null Perturb_1032_KO_Apoe_SRP197523 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.74019 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26095 H3K27me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pervasive developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44374 L428 DepMap CRISPR Gene Dependency 1.0 5.15407 BRD-K10987837 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19727 ELP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13294 IGLC3 Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03171 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A268-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null molecular transducer activity GO Molecular Function Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null azacyclonol-5398 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RAC3-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.17 medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68954 Serotonergic synapse KEGG Pathways 2026 1.0 null CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6356 cetirizine-4815 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FGF5 Pathway Commons Protein-Protein Interactions 1.0 null GID8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7728 Perturb_2604_OE_SEPTIN9_SRP159553 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.57297 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41034 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 BRK1 Pathway Commons Protein-Protein Interactions 1.0 null ventral part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22629 BRD-K89264608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14953 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2029 SMC4-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04299 Perturb_5264_OE_Dcaf11_SRP328699 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.35312 clonidine-3172 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FCGR3A Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7028 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GRAP2 Pathway Commons Protein-Protein Interactions 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46643 cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047978 Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null small molecule metabolic process GO Biological Process Annotations 2015 1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3449 AURKB_knockdown_92_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.49079 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58356 mafenide-2287 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K79658624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14572 Perturb_9714_KO_miR34a_SRP058984 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.11402 hsa-miR-511 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Myometrial Relaxation and Contraction Pathways(Homo sapiens) WikiPathways Pathways 2014 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8558 ESR-mediated signaling Reactome Pathways 2024 1.0 null MFN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29553 furazolidone-4178 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAJIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71959 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.85468 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.869106 SFMBT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.6442 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36807 CRCGN017_MCF10A.TP53.M_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.72635 BRD-K27610371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01179 TCEAL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23092 Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM83D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54705 ASXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13293 CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.9224 BRD-K04883778 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7729 BRD-K20735575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44157 WNT11 Pathway Commons Protein-Protein Interactions 1.0 null PSMB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07909 BRD-K56258950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3108 BRD-K49745983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76662 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862691 BRD-K17339982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52255 FEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52078 FZD10 Pathway Commons Protein-Protein Interactions 1.0 null intermedioposterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05374 BRD-K52956006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54781 GSE188870,GSE188871_4_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.10973 UQCRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13407 BRD-K25176380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14513 BRD-K26200435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35333 FGF6 Pathway Commons Protein-Protein Interactions 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ac2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.645 Lung squamous cell carcinoma_LUSC_TCGA-77-8146-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.00216 TEC Pathway Commons Protein-Protein Interactions 1.0 null GSE135400_1_v_0_kdm1b_human RummaGEO Gene Perturbation Signatures -1.0 null WNT8B Pathway Commons Protein-Protein Interactions 1.0 null DLX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73129 Perturb_8509_KO_Bmal1_ERP009958 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.33556 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9407 BRD-K35066174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.21441 GSE197571_2_v_1_foxm1_human RummaGEO Gene Perturbation Signatures 1.0 null WNT2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K99660943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38085 BRD-K07390518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.61931 Acute Myeloid Leukemia_LAML_TCGA-AB-2840-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0057 PMC11637729-BJH-205-2450-s001.docx-0-GATA2_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.TP53.M_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5766 primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.882986 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null JRK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72508 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN015_MCF10A_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.56125 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1 JASPAR Predicted Transcription Factor Targets 1.0 null NCIH526 CCLE Cell Line Gene Expression Profiles 1.0 2.40871 Splenic Diseases CTD Gene-Disease Associations 1.0 1.05721 SNUC5 DepMap CRISPR Gene Dependency 1.0 3.12583 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Reactome Pathways 2024 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45078 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN009_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.66955 prazosin-6475 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26692 Cellular responses to mechanical stimuli Reactome Pathways 2024 1.0 null CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.57625 NPIPB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81265 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.78087 Night blindness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.367 BRD-K40494117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04366 BRD-K05286676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31554 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04418 SOCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13741 norfloxacin-2253 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF382 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18596 PMC7925335__F2 PFOCR Pathway Figure Associations 2024 1.0 null BRD-A57285050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2152 KML1 DepMap CRISPR Gene Dependency 1.0 6.05412 rotenone-5915 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null etiocholanolone-4764 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXRED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00843 medial part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32334 WASF1 Pathway Commons Protein-Protein Interactions 1.0 null GSE211286_7_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K14255526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17438 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EP300_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.49 BRD-K27028848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58522 GSE125014_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JX-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5228698__F1 PFOCR Pathway Figure Associations 2023 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050425 SKRC20 DepMap CRISPR Gene Dependency 1.0 2.61331 FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome Pathways 2014 1.0 null antimycin A-2261 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.955723 GNB4 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15958 CEBPB-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ZNF682 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.2788 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05124 D283MED DepMap CRISPR Gene Dependency 1.0 4.60419 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.82816 BRD-K90673570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14574 Response of endothelial cells to shear stress Reactome Pathways 2024 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-EV-5902-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null G-protein gamma-like domain InterPro Predicted Protein Domain Annotations 1.0 null H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K50623282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25109 CRCGN015_MCF10A_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1323 mantle zone of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08833 ELK4-26923725-CHIP-SEQ-MESODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null WASH complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.826 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXP1_FOXP1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 triamcinolone-2241 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70807 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1232 BRD-K60543885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41802 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02742 BRD-K44664883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30706 BRD-K51568355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07872 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2828 phenacemide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20354 amiodarone-3296 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K97761115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10094 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S7-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nicardipine-5397 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04426 CRCGN016_MCF10A.TP53.M_24H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57862 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30564 PMC7738984__F8 PFOCR Pathway Figure Associations 2023 1.0 null BRD-K18428988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09301 BRD-K23292451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18837 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82578220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28011 CRCGN016_MCF10A.TP53.M_24H:C10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.71661 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.929891 septum (resp epith) BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null promethazine-6477 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30964167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96335 EFM-19 GDSC Cell Line Gene Expression Profiles 1.0 2.01675 Signaling by Wnt Reactome Pathways 2014 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60216304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05647 VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.957713 spectinomycin-3327 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14256 BRD-K70923850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42796 LAT2 Pathway Commons Protein-Protein Interactions 1.0 null IGHG4 Pathway Commons Protein-Protein Interactions 1.0 null sensory perception of chemical stimulus GO Biological Process Annotations 2015 1.0 null NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 2.65492 GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32289 BRD-K45612428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01329 ZNF414 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12029 COPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16649 SW620 BioGPS Cell Line Gene Expression Profiles -1.0 -1.09486 BRD-A16119053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08963 Zygotene cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.618 BRD-K22308901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37041 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33857 MPP-89 GDSC Cell Line Gene Expression Profiles -1.0 -2.10537 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1172 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.21115 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58726 GSE210101,GSE210114_7_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K96615474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22084 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K50859531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49086 signal transduction GO Biological Process Annotations 2015 1.0 null BRD-A31602150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0717 BRD-K05414181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10399 ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7433 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COX7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 PMC8388033__F4 PFOCR Pathway Figure Associations 2024 1.0 null Perturb_13843_KD_Fgfr1_SRP371980 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.78827 BRD-K23204256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27444 FOXJ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82081 Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.909688 Perturb_16713_KO_Prkab1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.14207 PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.954592 Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.861254 dorsolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01955 NPRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3863 REC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.53209 DTX3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84199 RGR Pathway Commons Protein-Protein Interactions 1.0 null cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.904599 18535662-TableS2d GeneSigDB Published Gene Signatures 1.0 null HES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12083 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.984944 CRCGN011_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.5345 WNT10A Pathway Commons Protein-Protein Interactions 1.0 null Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90705 thalidomide-2258 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_HEPG2_48H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.31671 CAKI2 CCLE Cell Line Gene CNV Profiles 1.0 1.5253 JHUEM7 DepMap CRISPR Gene Dependency 1.0 2.51039 BRD-K03730976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5086 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901886 response to glucagon GO Biological Process Annotations 2015 1.0 null BRD-K13257316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28286 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53636 CNR_KO_GDS2820_636_mouse_Skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12941 SOS1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K18094884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48386 NCI-H2172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12981 protein complex GO Cellular Component Annotations 2015 1.0 null BLTP3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45881 PNU-0230031-3632 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07667 ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.7759 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRICD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04569 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K16154498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33712 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 1.93257 PMC6756575__F4 PFOCR Pathway Figure Associations 2023 1.0 null nadolol-3359 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MOV10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80999 WASF3 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_4962_KO_Dot1l_SRP214101 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.29653 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32095 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16241 CRCGN016_MCF10A.WT.HP_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.1487 GSE154246_2_v_0_haspin_mouse RummaGEO Gene Perturbation Signatures 1.0 null HOXB7-26014856-BT474-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chemokine signaling WikiPathways Pathways 2024 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null NUDT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58209 amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07137 cellular response to stimulus GO Biological Process Annotations 2015 1.0 null CRABP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06047 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2027 salivary gland GTEx Tissue Gene Expression Profiles -1.0 -1.01387 BRD-K02987495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39641 BRD-K43624274 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06015 SEKI DepMap CRISPR Gene Dependency 1.0 4.29176 BRD-K31852848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47999 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058417 PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 102.611 Dopaminergic synapse KEGG Pathways 2026 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37453 Sensory perception of sweet, bitter, and umami (glutamate) taste Reactome Pathways 2024 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null Alcoholism KEGG Pathways 2026 1.0 null PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null Neurotransmitter receptors and postsynaptic signal transmission Reactome Pathways 2024 1.0 null GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22778 CRCGN014_HEPG2_24H:I02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52871 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069625 Signaling by WNT Reactome Pathways 2024 1.0 null