association	dataset	threshold value	standardized value
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157445
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153655
GSE157594_3_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alcoholic Intoxication, Chronic	DisGeNET Gene-Disease Associations	1.0	null
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.040168
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173067
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170963
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163338
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103524
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200916
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168874
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247931
Organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70499_4_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49044
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8044433-mmc4.xlsx-Sheet1-Acute_LPS_Microglia_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255324
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.94206
C6/36 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
RNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76581
A549_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170861
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156675
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208555
K562_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020405
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Peretinoin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0139687
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269097
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170486
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014726
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12529848-12967_2025_7217_MOESM3_ESM.xlsx-Table_S4-Table_S4_Associations_of_genetically_proxied_proteins_with_risk_of_atrial_fibrillation_by_MR-SPI_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00971236
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5755
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245929
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152166
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161845
Nafamostat (mesylate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0366269
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207783
Fingolimod (hydrochloride)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02276
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148993
A549_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017851
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
MCF7_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166131
GSE245390_2_v_1_acss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239519
Idoxuridine_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0070744
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.56963
K562_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174677
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130096
hfff2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250099
A549_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120959
GSE165916_1_v_2_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IHH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.731
GP5D	DepMap CRISPR Gene Dependency	1.0	2.75255
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
G26915XM	GlyGen Glycosylated Proteins	1.0	null
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S117	DepMap CRISPR Gene Dependency	1.0	4.17497
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22368
HPAFII	DepMap CRISPR Gene Dependency	1.0	2.0367
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Transverse flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.627
8331_SPC24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55569
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.451
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.143
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106274
Azithromycin (hydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0369767
GSE109530,GSE109531_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186579
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.033981
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.9603
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197349
Dinoflagellate sulcus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.058
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20495
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
U2 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.019
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133864
HEYA8_OVARY	CCLE Cell Line Proteomics	1.0	5.62664
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137848
G3BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32161
Berberine (chloride hydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01438
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131425_2_v_3_arg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RMC-6236_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0325305
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194485
Malotilate_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0316224
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179353
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC25A30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38829
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259438
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307765
PMC12823428-43587_2025_1018_MOESM3_ESM.xlsx-ST12-Supplementary_Table_12_Main_mendelian_randomisation_results_of_plasma_proteins_on_delirium_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254764
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232432
PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9517_UBE2R2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509465
MCF7_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101397
9250_TRAPPC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28079
K562_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201775
GSE193351_4_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tadalafil_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271908
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0480023
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151464
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201121
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170515
1860_CREB3L3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543238
GSE162276_2_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ferulic acid_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0163448
A549_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229394
MZT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30778
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
Palmatine (chloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0353683
K562_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221473
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161002
K562_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179764
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200065
A549_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217106
MCF7_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179483
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CH25H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63638
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40881
MCF7_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0368992
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Flumatinib (mesylate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0270933
GSE203131_0_v_1_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6858_PSMC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44305
ADGRE5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02266
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.94252
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171219
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238731
6875_PSMD7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.637
K562_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195864
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.661917
PMC8045971-Table_3.xlsx-vs_LPS_ctrl-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174536
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.598952
GSE167984,GSE167987_0_v_1_setd1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194605
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Verapamil_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0171688
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158388
Pronephric tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
K562_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162905
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12749580-42003_2025_9274_MOESM5_ESM.xls-Supplementary_Data_2A-Supplementary_Table2A_Full_results_of_the_proteome-wide_MR_in_deCODE_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.828879
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016326
Abemaciclib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181422
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8434
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029771
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31073
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0276207
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110828
PMC10311050-mmc2.pdf-107-ENSG00000171223_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
496100581_TCx_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64248
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160775
PMC8299217-mmc2.xlsx-Early_Resp_FOXJ1_high_Ciliated-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE249098_3_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139975_3_v_1_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134029_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188919
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.595
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169222
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.458
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.62633
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12858240-250457-res-1-at.pdf-39-HHEX_HHEX	Rummagene Transcription Factor Associations 2026	1.0	null
SKHEP1_LIVER	CCLE Cell Line Proteomics	1.0	2.30824
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224381
K562_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171655
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149462
Sapling	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113857
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171356
K562_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306727
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00750091
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_SOX15_CUT_Tag_top_10k_peaks_Related_to_Figure6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
WM115	DepMap CRISPR Gene Dependency	1.0	2.92751
Lipoic acid_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0125799
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PAICS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0629
K562_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145699
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.017458
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bimiralisib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0288798
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8985
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141036
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186971
PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_symbol_that_KD_acts_upon_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188483
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243836
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_2_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9585487-NIHMS1838959-supplement-4.xlsx-Downregulated-Table_S3_FOXC1_regulated_genes_FOXC1	Rummagene Transcription Factor Associations 2026	1.0	null
L-Thyroxine (sodium salt pentahydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017198
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210473
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.68621
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166319
Neratinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197048
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MFE319	DepMap CRISPR Gene Dependency	1.0	2.09377
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030317
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0476429
A549_Iniparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223897
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE156115_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249692
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320829
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129832
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46516
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0587604
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131736
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0343219
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227956
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302109
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153729
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Zileuton_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212204
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142908
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Actomyosin contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EDNRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05396
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.798536
A549_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203481
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100602_TCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13388
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.039498
TTYH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33281
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cellulose microfibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
Azithromycin (hydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0246436
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219747
Almonertinib (mesylate)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0280309
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0537943
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_1_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129679
A549_FLLL32_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167519
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220927
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC44	DepMap CRISPR Gene Dependency	1.0	5.85882
Procainamide (hydrochloride)_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106489
A549_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159744
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164958
PMC11426119-mmc2.xlsx-suppl_tab_S1-Table_S1_Pairwise_differential_gene_expression_between_WT_and_13Ala_PHOX2B_transfected_cells_either_17AAG_treated_or_untreated_PHOX2B	Rummagene Transcription Factor Associations 2026	1.0	null
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253169
PMC5995803__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226091,GSE226092_3_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1801
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236113
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218417
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SDHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05403
2121_DDX42_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523331
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198545
Intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135262
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149456
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vilanterol_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265071
MCF7_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014177
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232049
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229467
PMC6683136-41598_2019_47363_MOESM4_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU1544	DepMap CRISPR Gene Dependency	1.0	4.14525
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.77581
ERK5-IN-2_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.014729
Azithromycin (hydrate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0290447
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Levobupivacaine (hydrochloride)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0224822
POMGNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21778
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200352_10_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Epothilone A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114285
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8975
Fumaric acid_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0233595
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31487
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0278188
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00679129
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Proglumide_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245682
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134164
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016949
A549_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147304
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131018
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Delamanid_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199298
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158541
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260872
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02707
ARL5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66256
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.853
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Diammonium Glycyrrhizinate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0211962
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC10A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42918
A549_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141401
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-17-ZNF367_ZNF367	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134858
MCF7_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156167
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170786
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF584	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33254
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236108
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Azithromycin (hydrate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02843
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.968351
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162277
Pemigatinib_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0313341
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15189
Aag-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
CHERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89288
PMC6607928-iovs-60-07-32_file_S11.xlsx-no_change_NRL_mutants-human_gene_ortholog_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tadalafil_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0265424
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172498
Egg white	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.08
Menadione_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296948
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0996
K562_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250848
NB1	DepMap CRISPR Gene Dependency	1.0	6.12969
ZNF326	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0252
OXNAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00334
MCF7_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116891
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.303
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.026636
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00969402
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179965
A549_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207203
MCF7_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0110213
RHOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09571
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147222
K562_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174558
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rifaximin_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0261675
A549_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011488
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217699
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138393
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229644
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138946
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_7_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.48088
K562_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156165
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
U2AF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178152
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120517
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Methylprednisolone succinate_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0171507
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258299
L-Eflornithine (monohydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0238108
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Unnamed_9_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7050_RABGGTA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05017
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291255
SPTBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16046
Vinblastine (sulfate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0220996
EN	DepMap CRISPR Gene Dependency	1.0	2.16202
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150372
K562_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0345904
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120757
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160366
CCDC121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05777
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565917
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131132
MCF7_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186585
NCIH2126	DepMap CRISPR Gene Dependency	1.0	2.24926
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.48504
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4986885__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-BRF2_BRF2	Rummagene Transcription Factor Associations 2026	1.0	null
3308_GBF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4788
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546678
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119495
A549_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018734
FAM72B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35086
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188382_4_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165339
PMC12663156-41467_2025_65429_MOESM3_ESM.pdf-8-PLASMA_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289327
IGROV1_OVARY	CCLE Cell Line Proteomics	1.0	3.17622
SEZ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54411
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198078
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125623
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0325105
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188851
MCF7_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247345
4956_MED6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547668
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5182
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8040_SLC35A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.665836
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0079468
PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148543
GaMG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193798
TLE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32437
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161069
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019781
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183896
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00784305
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128763
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112542
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151605
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_G007-LK_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182598
Larval cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253529
A549_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206523
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0539
Edoxaban (tosylate monohydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0275591
MCF7_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211032
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6070530-41398_2018_200_MOESM3_ESM.xlsx-regional_cluster_PFC-MSC-age-bin_5_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206215
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026499
K562_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167293
Almonertinib (mesylate)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.036091
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170171
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7519331-pnas.1921408117.sd11.xlsx-ERM_OMM_DualBiotinylated_APEXSq-Ensembl_Gene_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9046280-41467_2022_29963_MOESM5_ESM.xlsx-ASCL1_motif-Gene_Name_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
7163_RBM19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04736
K562_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322716
Rosiglitazone_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021546
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174026
MCF7_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200855
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249384
A549_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159389
496100529_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31065
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06335
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02697
K562_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149699
KMRC1_KIDNEY	CCLE Cell Line Proteomics	1.0	2.31967
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
8633_SYS1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06101
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Norepinephrine (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0272579
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_6_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ES8	DepMap CRISPR Gene Dependency	1.0	2.49377
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015987
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138256
4161_IPO13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504768
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erlotinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0200035
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	1.0	null
CMLT1	DepMap CRISPR Gene Dependency	1.0	2.13528
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317583
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160826
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YJU2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38127
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165078
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.654499
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
ATRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26847
PMC4383005-ncomms7500-s3.xlsx-Supplementary_Table3-Supplementary_Data_2_HES5_vs_HES5-_expression_intensity_ratios_during_NSC_progression_HES5	Rummagene Transcription Factor Associations 2026	1.0	null
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142353
SW626	DepMap CRISPR Gene Dependency	1.0	2.2311
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rucaparib (phosphate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0179822
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181056
GSE144796_1_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191835
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155685
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121299
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100572_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05553
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117514
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252541
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Symbol_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9147
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0367526
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142814
GSE210580_4_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213639
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141112
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
MCF7_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199815
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3479_GOSR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24663
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CD74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04464
A549_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206837
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20896
A549_Ellagic acid_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136788
Peretinoin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244765
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136479
Intrinsic component of postsynaptic specialization membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137996
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249421
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184505
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151067
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293574
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6070530-41398_2018_200_MOESM3_ESM.xlsx-regional_cluster_PFC-MSC-age-bin_6_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200352_10_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
547_ARRB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18262
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02693
Bimiralisib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175494
Sonidegib_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0163127
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8911
A549_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167489
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Almonertinib (mesylate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0324194
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291884
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.618684
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013527
K562_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151687
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234524
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ligustrazine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244588
v91	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC13127299-mmc2.xlsx-FOXM1_kdRNAseq-hgnc_symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12439337-thnov15p9091s1.pdf-75-ENSG00000124766_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06974
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59913
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0379043
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Ensembl_ID_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248621
Talc_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0208887
Aspirin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240579
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280914
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152717
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106015
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37437
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3522_GPT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567833
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177633
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1622
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0364447
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145885
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188874
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0435
KIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14346
HCT116	DepMap CRISPR Gene Dependency	1.0	5.56978
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206161
K562_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211882
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161449
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96771
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0437175
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
A549_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0370468
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156574
PMC10350077-media-8.xlsx-Controls_LPS_enriched_Down_KEGG-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MIOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13679
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178491
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01573
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289303
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100598_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12362
RO60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38761
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H69 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
K562_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188718
K562_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0413268
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158174
SUM159PT	DepMap CRISPR Gene Dependency	1.0	3.27319
A549_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264422
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210213
6876_PSMD8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11516
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Patupilone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01134
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236945
K562_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279307
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244253
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
GIMEN	DepMap CRISPR Gene Dependency	1.0	3.00488
ZFP41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7474
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203329_0_v_3_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bosentan (hydrate)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260185
MCF7_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168297
Clotrimazole_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237229
COGAR359	DepMap CRISPR Gene Dependency	1.0	2.35572
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279114
Rifaximin_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027428
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Peretinoin_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0187311
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00643981
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Busulfan_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0194075
Ixazomib citrate_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0178601
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196605
PMC6880099-mmc1.docx-0-Table_S1_Protein_targets_of_6-OHDA-PEG3-yne_identified_by_mass_spectrometry_1_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211045
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151601
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Electrocardiogram morphology (amplitude at temporal datapoints)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
PMC5997167__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00890977
MCF7_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113836
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135438
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266855
Endomembrane system	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8091
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117275
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.9592
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158211
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142963
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160001
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020076
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170921
Arbutin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0151508
MCF7_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101581
MCF7_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128857
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0504327
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133597
WRAP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3321
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2977
GSE160373_1_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE4	DepMap CRISPR Gene Dependency	1.0	4.00293
GSE226452_1_v_2_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111409
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Gefitinib_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244621
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303826
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180185_7_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131206
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
L1236	DepMap CRISPR Gene Dependency	1.0	3.01296
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0294
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175323
G22625SJ	GlyGen Glycosylated Proteins	1.0	null
U1 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.031
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10350077-media-8.xlsx-PPM1D_tr_LPS_vs_Cont_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139626
(S)-Crizotinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175359
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00653196
4389_KIF23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03383
GSE217115_3_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154306
Resveratrol_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024911
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Methotrexate_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.021352
ODAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76047
3639_HAUS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564987
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153594
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237261
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211401
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177792
Selinexor _NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204843
K562_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248714
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161014
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cellular anatomical entity	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0364518
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0444496
PMC11634769-44161_2024_567_MOESM3_ESM.xlsx-ST_8-Supplementary_Table_8_Steiger_filtering_results_for_protein-disease_pairs_tested_in_sensitivity_cis-Mendelian_randomization_MR_analyses_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176004
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27045
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.31792
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPI-anchor transamidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_16-Table_16_Information_of_genetic_instruments_used_for_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CJM	DepMap CRISPR Gene Dependency	1.0	3.54157
UMUC6	DepMap CRISPR Gene Dependency	1.0	2.15164
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Postsynaptic specialization membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151047
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0393318
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025805
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271036
Chlorhexidine (diacetate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.016553
A549_Belinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.016962
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
Almonertinib (mesylate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0292703
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Thymopentin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0276352
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149298
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145678
PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018565
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6962
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121599
RPUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19743
MCF7_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199897
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0390139
GSE200352_9_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC38	DepMap CRISPR Gene Dependency	1.0	2.63636
Pimozide_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0211224
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158823
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8333
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45592
RCM1	DepMap CRISPR Gene Dependency	1.0	3.38488
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2977
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234816
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00953204
PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-CON_VS_LPS_252-Gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7481169-277_2020_4194_MOESM7_ESM.xlsx-RUNX1_R139G-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Nephridium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205264
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252773
Proglumide_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216684
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.817735
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150521
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09663
K562_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267083
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174627
PMC10103678-11427_2023_2316_MOESM4_ESM.xls-THP1_mRNA_binding_Protein_PMA--Unnamed_3_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107712
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192983
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154577_2_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018529
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
Ouabain (Octahydrate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260693
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0802
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
G29068FM	GlyGen Glycosylated Proteins	1.0	null
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.64934
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216637
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194635
MCF7_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144928
K562_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0406081
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Phenylephrine (hydrochloride)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200296
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228444
LB-100_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156384
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225869_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144401
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
G43417UB	GlyGen Glycosylated Proteins	1.0	null
GSE184892_0_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122823
PACADD161	DepMap CRISPR Gene Dependency	1.0	2.867
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182068
K562_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0297584
PMC7899452-media-3.xlsx-Early_Resp_FOXJ1_high_Ciliated-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
Ropivacaine (hydrochloride monohydrate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0194734
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6869_PSMD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45092
Golgi stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.976
PMC11634769-44161_2024_567_MOESM3_ESM.xlsx-ST_7-Supplementary_Table_7_F-statistics_and_R淪estimates_for_the_genetic_instruments_tested_in_cis-Mendelian_randomization_MR_analyes_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217853
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154607
Tadalafil_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0293817
Silodosin_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260297
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HYAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13156
GSE125007,GSE125008_5_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154464_0_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brimonidine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188896
MCF7_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188894
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_11-Table_11_The_association_of_genetically_predicted_levels_of_proteins_with_the_risk_of_HF_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CHAGOK1_LUNG	CCLE Cell Line Proteomics	1.0	2.31967
A549_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204014
Trimetrexate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0309743
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149605
CESS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
Quinidine (15% dihydroquinidine)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244048
2125_DDX49_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.47836
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0290698
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292504
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164874_5_v_13_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206519
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145283
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105276
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291392
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00593827
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194682
UNC5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00327
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mesocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_signficantly_upregulated_313_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210655_3_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
l540	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56332
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192576
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_5_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5492_NCAPH_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08603
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3201
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6207
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245426
ZNF718	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11078
Resveratrol_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0273494
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192836
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023694
Tucatinib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.03055
MCF7_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165521
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303409
A549_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013875
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230802
A549_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120422
ACY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33033
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01407
MCF7_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157027
ARL14EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12615
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.8619
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261466
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203155
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108695
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0272367
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Panobinostat_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0367324
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237076
K562_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221069
CASKI	DepMap CRISPR Gene Dependency	1.0	2.53055
K562_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201798
K562_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270111
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175434
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-6.64132
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159157
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
L-Eflornithine (monohydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0177104
Berbamine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0214353
A549_Abexinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013123
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5112
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-2_E2F1-Gene_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210383
CDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07298
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141144
SKRC20	DepMap CRISPR Gene Dependency	1.0	3.41936
Lopinavir_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0263737
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154464_0_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211235
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029546
PMC5159535-supp_gkw757_nar-00810-met-z-2016-File016.xlsx-S9_SOM-Unnamed_3_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4029819-pone.0098069.s004.xlsx-SAM_FOXA1_h_vs_FOXA1_l-Table_S3_SAM_analysis_of_FOXA1_high_versus_FOXA1_low_cases_FDR_0_01_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538783
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34551
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10703676-41588_2023_1569_MOESM4_ESM.xlsx-ST18-Unnamed_2_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TPRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08012
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
UACC893	DepMap CRISPR Gene Dependency	1.0	3.08529
AT7519_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0166722
GSE162276_2_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22727
GSE162276_2_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00891691
Darolutamide_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0101393
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166571
MCF7_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161462
GSE70499_4_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208435_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027439
DUSP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04729
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171099
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298767
A549_EED226_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286026
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NOLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34864
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2052	DepMap CRISPR Gene Dependency	1.0	2.25377
K562_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02314
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303901
Malotilate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294969
Silodosin_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155848
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4572
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-BAZ2A-regulated_genes_with_BAZ2A-bound_promoter_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150943
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195457
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0507
MCF7_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182485
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220657
Tadalafil_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0173678
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.5283
dm15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.126
6150_PDAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.657077
KYSE450	DepMap CRISPR Gene Dependency	1.0	2.48751
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148947
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00960579
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3229
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Bexarotene_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214806
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Tofacitinib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0294398
MAPACHS77	DepMap CRISPR Gene Dependency	1.0	2.03089
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180799
K562_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189612
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244069
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155374
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dapagliflozin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0207547
TTC642	DepMap CRISPR Gene Dependency	1.0	2.79798
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104016
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSME3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16818
DEPDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92539
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216043
EBC1	DepMap CRISPR Gene Dependency	1.0	4.71164
Digitoxin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.015198
Cysteamine (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284649
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222217
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18802
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238126
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192765
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9521_UBE2V2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526503
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181874
Azithromycin (hydrate)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0235442
GSE149903_4_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141183
5054_MICAL3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.927181
Mebendazole_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0224684
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9646482-mmc13.xlsx-ST13B_AA-specific-regions-Unnamed_13_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013853
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216879
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00567447
GSE205070_1_v_4_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111715
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203036
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018913
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175839
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674712
K562_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207505
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Proglumide_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.026321
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015254
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Bicalutamide_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00725354
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170302
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0383408
HUCCT1	DepMap CRISPR Gene Dependency	1.0	3.2172
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570456
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
n18	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
K562_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191299
K562_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144349
K562_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143182
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303267
Chlorhexidine (diacetate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192117
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1648	DepMap CRISPR Gene Dependency	1.0	3.25667
Elytron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
A549_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165896
ZNF709	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50795
K562_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176487
Azithromycin (hydrate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015277
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288799
NB4	DepMap CRISPR Gene Dependency	1.0	2.93838
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0281325
7568_RRP9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12683
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Verapamil_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.025575
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176285
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021266
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220317
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268037
K562_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156255
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.2065
AT7519_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0125669
A549_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248369
NVP-BHG712_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00714512
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153174
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102616
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018025
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
U2-type spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.089
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209159
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238848
HAUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48106
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28355
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246782
POLR3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63432
A549_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142297
PMC11257892-Table_1.xlsx-S2-Supplementary_Table_S2_All_results_of_the_preliminary_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
3568_GTF2B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530376
A549_Selisistat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271975
CL11	DepMap CRISPR Gene Dependency	1.0	2.12278
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210592
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164066
GSE70499_3_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Asciminib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0215849
Drospirenone_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0194523
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12180985-BLOODA_ADV-2024-014495-mmc1.pdf-35-CREBZF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159444
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Coleoptile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
Penfluridol_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0296374
G57321FI	GlyGen Glycosylated Proteins	1.0	null
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0430877
PMC11252405-41467_2024_50426_MOESM4_ESM.xlsx-Fig_S4c-CTCF_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_8_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Resveratrol_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0232505
K562_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206792
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179079
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126988
A549_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157457
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
C8166	DepMap CRISPR Gene Dependency	1.0	3.77475
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020601
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330873
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
L-Thyroxine (sodium salt pentahydrate)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.017776
SUPT7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43006
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Vitamin K4_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152261
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZSWIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20975
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149095
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242049_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25243
GPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18774
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160029
PMC7923093__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148695,GSE167281_0_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251877
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAK-901_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0107002
Procainamide (hydrochloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0147025
Sonidegib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0259561
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276638
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intrinsic component of synaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.719
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.665698
Belumosudil_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0313558
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696558
HNRNPUL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84733
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G47012YE	GlyGen Glycosylated Proteins	1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00947384
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182033
PMC12869252-mmc1.xlsx-ST19-Supplementary_Table_19_Results_of_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285248
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
Goserelin (acetate)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0281151
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNUC5	DepMap CRISPR Gene Dependency	1.0	4.11961
GSE48812_8_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi apparatus	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.09823
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517312
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CSPG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92771
A549_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151835
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Endo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06102
GSE200352_9_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostomium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
GSE60691_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.555548
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172406
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140997
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232127
HEP3B217_LIVER	CCLE Cell Line Proteomics	1.0	2.13381
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0300289
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Almonertinib (mesylate)_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0257467
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
7522_RPS2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05353
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phenytoin (sodium)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.021682
Azithromycin (hydrate)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185803
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320657
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Minodronic acid_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0229765
C15orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00018
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248763
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015233
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198284
ATP5MF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60362
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
MCF7_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110262
GUCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04519
Dexamethasone_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00754844
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H358 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160212
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205773
MCF7_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014423
K562_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134513
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.018773
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162276_2_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02256
Sonidegib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0185502
Bestatin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029652
EVSAT	DepMap CRISPR Gene Dependency	1.0	6.95528
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198279
KMS-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
A549_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127703
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	2.18428
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Azithromycin (hydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0277565
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153663
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265874
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lc90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.112
Berbamine (dihydrochloride)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176235
C32_SKIN	CCLE Cell Line Proteomics	1.0	5.9696
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167261
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45959
9857_WEE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27446
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Panobinostat_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0108492
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neuroepithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0416631
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268043
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162959
GSE202017,GSE202018_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146426
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142269
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225945
MCF7_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016848
Econazole_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190449
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139559
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256156
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152042
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
A549_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0283508
Lactate (calcium)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0225455
METTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59161
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239484
K562_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154293
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40175
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515686
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KATO-III cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
K562_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178318
A549_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00946104
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4D-Supplemental_Table_S4D_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149254
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193662
bl20	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
GSE161864,GSE161866_1_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2124_DDX47_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02863
CA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04997
Almonertinib (mesylate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0307274
K562_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152843
SULT4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12078
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3103_FKBPL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556451
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.45593
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144357
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184808
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71927
CACFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00101
7968_SLC16A5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14427
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01674
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1793_LUNG	CCLE Cell Line Proteomics	1.0	4.37645
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145202
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8346
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158173
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.865411
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010669
A549_UNC1999_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167441
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149195
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.358
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32495
Catalytic step 1 spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162218
Levobupivacaine (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208519
A549_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268774
SNU182	DepMap CRISPR Gene Dependency	1.0	3.50486
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128906
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247028
PMC7519331-pnas.1921408117.sd18.xlsx-ERM_OMM_DualBiotinylated_APEXSq-Ensembl_Gene_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121108
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167802
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4193
K562_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0257565
CAL-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
PMC6684084-pntd.0007589.s007.xlsx-Sky_Blue_Module-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148511
A549_Azacitidine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133264
PMC2866657-pone.0010547.s003.xls-ERG_corr-Genes_correlated_anticorrelated_to_ERG_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250705
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146579
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168019
CXorf38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19922
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265695
MCF7_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111989
Dimethyl fumarate_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169405
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2574
Terfenadine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0230306
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165871
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247139
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171118
MCF7_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184177
MCF7_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016026
K562_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244188
1423_CDK11B_ENST00000341832.6	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532215
5735_NOL6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03956
A549_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153773
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016348
DSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15414
ZNF254	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00348
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174383_6_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05681
Ranolazine_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0287892
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153004
Adagrasib_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0258864
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166028
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232743
Peretinoin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227791
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05866
Almonertinib (mesylate)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0322521
GAMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26596
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163659
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4734
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159795
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231314
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
c32	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHH	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
IQ 1_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0264614
Vortioxetine_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0126826
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197538
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4882
BRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72671
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
ANKRD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03374
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138809
Furosemide_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00785589
GSE153189_1_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ivermectin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0128569
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Topotecan (hydrochloride)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237823
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138068
Rosiglitazone_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260487
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08822
Paclitaxel_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192124
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229146
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
6849_PSMB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08039
A549_EED226_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.01353
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135633
ELF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47489
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Malotilate_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0302647
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116501
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144067
L-Eflornithine (monohydrochloride)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0158483
Silodosin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0211042
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08826
Apalutamide_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177035
K562_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326858
UQCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37065
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.721198
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SH10TC	DepMap CRISPR Gene Dependency	1.0	2.4594
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_17_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4554_LEPROTL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06593
Peretinoin_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192224
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242911
A549_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206275
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146247_0_v_1_sirt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199186
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192549
A549_2-Methoxyestradiol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190988
CRAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1675
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144405
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112266
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220356
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05473
7057_RAC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39928
Intrinsic component of postsynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.91
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MORCPR	DepMap CRISPR Gene Dependency	1.0	5.5587
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Radotinib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251359
K562_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015464
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13269
Bicalutamide_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176052
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_13-Table_13_MR_Steiger_analysis_to_infer_the_MR_causal_orientation_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150259
A549_Barasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149509
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5926
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191131
Clobetasol propionate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0236102
GSE133927_1_v_0_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0321379
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179413
MCF7_Tanespimycin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144243
A549_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174487
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112238
Silodosin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0195656
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120042
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
4107_IMP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514647
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503865
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CKM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.769
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167679
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264018
PMC8635809-Table_2.xls-LPS-upregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151635
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0310965
GRK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08455
A549_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144052
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538676
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1395
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.77614
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.327
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCH	DepMap CRISPR Gene Dependency	1.0	3.38157
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Triclosan_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0201331
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121921
MCF7_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022924
PMC12103066-FEBS-292-2688-s001.pdf-163-LCOR_LCOR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_1_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226475
GSE225869_1_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191066
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184764
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ruxolitinib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173709
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031443
NUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39863
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tucidinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137203
MCF7_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225384
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023614
PRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85511
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025722
PMC11936835-41562_2024_2078_MOESM4_ESM.xlsx-Supplementary_Table_10-Supplementary_Table_10_MR_analyses_of_proteins_and_protein_modules_on_social_isolation_and_loneliness_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126843
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-N-MC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.0669
MCF7_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147817
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7507
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156264
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179085
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Regorafenib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260026
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163021
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2653
MCF7_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200299
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Epithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
Tadalafil_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0230091
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25222
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218064
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246137
GSE65617_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172741
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190282
BICR78	DepMap CRISPR Gene Dependency	1.0	4.08359
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0332531
Verteporfin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00879221
Decitabine_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0131843
MRPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04135
A549_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151778
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9798_BUD23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.91253
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016693
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0389504
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
mp90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
A549_Bisindolylmaleimide IX_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181999
Verteporfin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256905
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15949
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210592
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.59807
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7281
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HT1197	DepMap CRISPR Gene Dependency	1.0	2.41048
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538567
Intracellular anatomical structure	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	4.077
Roxadustat_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0110177
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE60837_6_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
THAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36328
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mono-Mac-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
Azithromycin (hydrate)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242991
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02498
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0389119
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00772506
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147497
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136333
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.866653
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fulvestrant_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.024557
L3MBTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08483
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0709
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200839,GSE233826_5_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180435
GSE207582_2_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Berbamine (dihydrochloride)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0137344
K562_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155124
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.70534
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210717
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.81669
K562_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156925
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180932
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
l23	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00822574
TLE5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04395
496100589_PCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59812
MCF7_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126123
Rutin (trihydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0286245
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156459
GSE228181_0_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.10036
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240154
OVCAR-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
A549_FLLL32_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.028561
GOLM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05354
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SYNRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59311
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263177
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	8.269
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tongue cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11748740-41598_2025_85338_MOESM1_ESM.xlsx-Table_S2-Table_S2_The_cis-pQTLs_Pass_Instrumental_Variable_Selection_Test_for_Primary_MR_Analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227924
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.796374
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.64889
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236563
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162844
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017507
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223134
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.7443
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0290075
MCF7_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119385
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239366
SBI-0640756_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021054
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158514
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201218
SKMG1	DepMap CRISPR Gene Dependency	1.0	4.03863
GSE124014_0_v_1_nnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spliceosomal snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7096
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146469
S1PR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19063
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157873
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114301
Artesunate_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255734
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202631
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0518843
ATXN7L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36466
BT16	DepMap CRISPR Gene Dependency	1.0	2.92447
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254382
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162019
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191494
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0334092
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139794
GSE58498,GSE58501_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194641
Idarubicin (hydrochloride)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149463
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60775
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229042
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125592
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0485244
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130515
Sonidegib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0143808
K562_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018013
Small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782