association	dataset	threshold value	standardized value
4881_MBNL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598091
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-408-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF556	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0145
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
VAC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03529
Renal glomerular capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.606
Undecanoic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6004
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26403
CHEMBL1902935	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
PSMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68213
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
NPRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1109
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8987
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5498
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8214
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tideglusib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16087
Zaltoprofen	DeepCoverMOA Drug Mechanisms of Action	1.0	0.58
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_significantly_downregulated_739_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4021073-1471-2407-14-278-S4.xlsx-Sheet1-Supplementary_Table_S5_Genes_with_GATA3_ChIP-seq_peak_within_10kb_from_transcription_start_site_TSS_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.87159
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340825
Quinidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
496100432_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14194
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583065
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
GSE146865,GSE146866_4_v_3_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16451
DP-agonist13	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0085
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33793
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.23616
LY 364947	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
Sarcoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.246
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.4637
MIOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4851
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2369
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
tRNA threonylcarbamoyladenosine modification	GO Biological Process Annotations 2023	1.0	null
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
TSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06297
CTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22318
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tRNA modification	GO Biological Process Annotations 2023	1.0	null
NS309	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
Dexrazoxane	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0272
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4976
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4871
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8467_ST20-MTHFS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.704538
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605602
COX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19992
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8616
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4052
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3805
SNU216	DepMap CRISPR Gene Dependency	1.0	3.41544
GNAQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36543
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1291
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PGAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01097
OVSAHO_OVARY	CCLE Cell Line Proteomics	1.0	4.21441
JVE015	DepMap CRISPR Gene Dependency	1.0	2.28238
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleolus	GO Cellular Component Annotations 2025	1.0	null
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Milrinone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29674
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tipifarnib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.57
Congenital hypothyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443167
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1505
SLC22A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21695
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
C18orf21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0916
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
COQ5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39338
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2205_DHX29_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598755
Ciliated cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169155_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0212
L-Menthol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
Bone cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.558
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
U1 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9357
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.584
nucleolus	GO Cellular Component Annotations 2023	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
IMR32	DepMap CRISPR Gene Dependency	1.0	2.44571
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
KDM6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40477
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.957
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45448
GSE112860_9_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALHM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36733
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Necrostatin 2	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3411
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9876
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316052
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04222
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	3.89527
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65354
LY334370	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1839
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374319
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6424098-mmc5.xlsx-CEBP_Binder-Gene_names_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145476_2_v_3_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
TNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38037
tRNA threonylcarbamoyladenosine metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Darunavir	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.732443
PS-1145	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.286
HS695T	DepMap CRISPR Gene Dependency	1.0	2.40027
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1929_CTDP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09968
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6729
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.584
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2795_EXOSC8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.734026
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
HDGFL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10412
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350259
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BICR6_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.22713
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EWP-815	DeepCoverMOA Drug Mechanisms of Action	1.0	0.61
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10802
Siponimod	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.62
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Harderian gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
C8166	DepMap CRISPR Gene Dependency	1.0	5.23576
SYO1	DepMap CRISPR Gene Dependency	1.0	3.31814
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
ALG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41626
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Tracheal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
CRLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71202
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339913
Actonel	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4411
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210476_2_v_1_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1482
ZNF625	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10444
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5271
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.584
SKRC20	DepMap CRISPR Gene Dependency	1.0	2.9523
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neuroendocrine tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.033
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135514_8_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Desipramine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
GW7647	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395387
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNAse mitochondrial RNA processing (MRP) complex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276353
Skeletal muscle cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ABITRAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36638
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5823
HCT116_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	14.9261
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.089
MMP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26343
PMC11932929-41388_2024_3264_MOESM4_ESM.xlsx-p_0_05_FC_0_5_n_675-Differentially_expressed_genes_in_MCF7_AR-isolated_BCSCs_after_4_days_GSK591_500nM_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HG3	DepMap CRISPR Gene Dependency	1.0	2.40187
PMC5732738-oncotarget-08-103415-s002.xlsx-CAMA1_DEGs-Genes_differentially_expressed_by_1_25_fold_between_parental_CAMA1_cells_and_GATA3_mutant_knock-in_clone_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206870,GSE206872_4_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4007
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.869
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0867
GSE148252_0_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9481
8221_SNRNP48_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05405
JAK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05473
BON-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
HB-24-GP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229753
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00172
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHYHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09245
SOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02041
NACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7326
ZJ 43	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
BLOC1S6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08947
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1008
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268175
PRKDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10273
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
ABHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08569
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
3583_GTF3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37154
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ro 28-1675	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
OBSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7258
OLFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13579
PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GNF-5	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5437908__F2	PFOCR Pathway Figure Associations 2023	1.0	null
3308_GBF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16963
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23228
ML221	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
COX7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97754
Acute promyelocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HJC0350	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
UA-06-UV98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253501
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.584
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MHCC97-H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
SB290157	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
Hiatus hernia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
TSPAN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03312
UBR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14949
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9839
PPP1R16B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53278
Leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Senicapoc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TSPOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15494
tRNA modification	GO Biological Process Annotations 2025	1.0	null
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DHX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60944
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
HSPA12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1766
ATOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01288
NFPS	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9723
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
W-13 HCl	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SERTAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01305
Hypothalamus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288596
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	5.622
PMC9314667-Table_1.xlsx-Regulons-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563187
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217978
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0252
C21orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01788
PMC3500769-srep00875-s3.xls-PAX2-Time_0_PAX2	Rummagene Transcription Factor Associations 2026	1.0	null
Htk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.738
496100488_TCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10151
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.978
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9462
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.898555
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502695
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.514
PMC5437908__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRS 1754	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337435
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9778
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2419
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260243
BRL 54443	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390979
CD-13-QZ32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202035
PCNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04796
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ECC4	DepMap CRISPR Gene Dependency	1.0	4.68464
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
tRNA-intron endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.449
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Galloway-Mowat syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.333
ABHD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49069
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.904718
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37791
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leiomyosarcoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Proteinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.748
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
ACVR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94323
AA-01-XV28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218698
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_increase_in_MLL-AF4_ChIP-seq_signal_371_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH1836	DepMap CRISPR Gene Dependency	1.0	3.39
Glomerulosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
7690_SCD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542766
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.632574
L-165041	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
EKC/KEOPS complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC8299217-mmc3.xlsx-FOXJ1_high_Ciliated_Cells-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Platelet alpha granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.988
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59071
KLF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15518
ROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44668
nucleus	GO Cellular Component Annotations 2023	1.0	null
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45063
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9927
ESS1	DepMap CRISPR Gene Dependency	1.0	2.02934
ORC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30086
SGC0946	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2481
SNUC4	DepMap CRISPR Gene Dependency	1.0	9.59237
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368011
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6629_PPIL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500729
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.7867
CCC5	DepMap CRISPR Gene Dependency	1.0	5.089
WM115	DepMap CRISPR Gene Dependency	1.0	2.71861
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Dapagliflozin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04064
KDM7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14284
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hypertensive encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
T-lymphocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Aprepitant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.62
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1045
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27578
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3134
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ABT-199	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
TBC1D24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55832
MALME3M	DepMap CRISPR Gene Dependency	1.0	5.5908
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
Amniotic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	4.22855
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.928
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02669
BBX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17317
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3513
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6916
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GALNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3136
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
OGFOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13265
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.042
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4441
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
COLO829_SKIN	CCLE Cell Line Proteomics	1.0	2.49004
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Periplasmic side of cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532139
GSE168797_4_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UMUC16	DepMap CRISPR Gene Dependency	1.0	2.27418
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	3.92706
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.575002
MI-3	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4885
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
C2CD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31948
FAM47E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38122
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4486
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fumitremorgin C	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02985
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80993
BRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05357
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319684
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32251
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4876
HUO9	DepMap CRISPR Gene Dependency	1.0	2.73383
CHEMBL1643306	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
DUXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50958
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
FDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0771
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
No annotation - 5	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
AML-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5845
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NAA50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10011
ZC3H11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18567
496100582_HIP_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07604
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SAYSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39722
ZNF175	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21255
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4331
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271931
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9808
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
Galloway-Mowat syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.742
PRSS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14036
Zosuquidar	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
Ospemifene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GK01981	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_37_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225869
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE100316_3_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190947_1_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.505
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0737
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
TMED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34912
Chlorsulfuron	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
NSC95682	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.48
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254165
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541928
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35295
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NSUN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03356
Ralfinamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
C99	DepMap CRISPR Gene Dependency	1.0	3.72196
RBM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96222
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
EKC/KEOPS complex	GO Cellular Component Annotations 2025	1.0	null
Cilostamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
DB	DepMap CRISPR Gene Dependency	1.0	2.15433
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2386
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7469
SNU1079	DepMap CRISPR Gene Dependency	1.0	4.29318
Capsular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.619
Imaginal disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.014
BW 723C86	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7A-Table_S7A_Hippocampal_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6442
RSPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61179
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H727 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2327
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
2796_EXOSC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.628299
Montelukast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
Transcription factor TFIIA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.986
Rpd3L complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
PMC3342315-pone.0036054.s011.xlsx-overlap_PBX1_ChIP_siRNA-Unnamed_5_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00341
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20233
5165_MPHOSPH8_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563526
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ICC2	DepMap CRISPR Gene Dependency	1.0	2.90606
Nephrotic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.099
Binospirone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	4.22869
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133661_0_v_1_c19orf12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lomitapide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
TFDP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60708
Cytosolic small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
PMC3500769-srep00875-s3.xls-CEBP-Time_0_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31183
PMC11237666-spectrum.03516-23-s0004.xlsx-FOXJ1_high_Ciliated_Cells-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86851
SPATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3117
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Defactinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GAL3ST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17007
Ziprasidone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5325
MTREC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13927
CALM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92432
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40371
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
EKC/KEOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.489
PRPF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9343
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7057_RAC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08576
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.871
PF-514273	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.35084
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	0.943846
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.9335
NOL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43967
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5014
RPS19BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76854
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53309
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13604
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264276
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236815_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Epristeride	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-257-FOXN3_FOXN3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Galloway Mowat Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.559958
CCLFUPGI0005T	DepMap CRISPR Gene Dependency	1.0	2.41492
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tRNA methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.278
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57831
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217856
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-28-MC54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221293
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5004_METTL3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505058
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.7894
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
4-Methylhistamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCC142	DepMap CRISPR Gene Dependency	1.0	2.31854
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257153
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16269
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2641
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183251_7_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NHLRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0359
CHEMBL2041153	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
KYO1	DepMap CRISPR Gene Dependency	1.0	3.27596
PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_2_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30691
VU0152100	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260968
2789_EXOSC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505641
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86836
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Atomoxetine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.755834
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05381
tRNA threonylcarbamoyladenosine modification	GO Biological Process Annotations 2025	1.0	null
ERCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12427
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.418
Amnion epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8796
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.5772
IU1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
TC138	DepMap CRISPR Gene Dependency	1.0	2.08213
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Desvenlafaxine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
TTC709	DepMap CRISPR Gene Dependency	1.0	5.47512
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A3KAW	DepMap CRISPR Gene Dependency	1.0	4.99162
PMC7899452-media-4.xlsx-FOXJ1_high_Ciliated_Cells-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9679
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHEMBL1348080	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dimethylfraxetin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6075
KMS27	DepMap CRISPR Gene Dependency	1.0	2.99187
MM160113	DepMap CRISPR Gene Dependency	1.0	2.23678
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0549
Bam protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
TMEM230	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6057
POLR2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73691
SHSY5Y	DepMap CRISPR Gene Dependency	1.0	2.41596
Epilepsy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
MAML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16172
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
PANC0504	DepMap CRISPR Gene Dependency	1.0	2.97222
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0001
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01087
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.964
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289768
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleoli	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85851
SRRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31352
SYT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79511
VIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41135
Dried cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SENP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85405
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4495416-srep12003-s1.pdf-79-TCF7L2_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
Glomerular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.614
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210053
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4616
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02087
UBALD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16354
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230487
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intrinsic component of periplasmic side of cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
Galloway-Mowat syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.475
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09332
GSE239578_2_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308622
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Focal segmental glomerulosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.89309
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1988
GBGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12307
NOL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17527
GSE71468,GSE76476_0_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
APOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03637
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
THAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3732
USPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53174
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKUT1	DepMap CRISPR Gene Dependency	1.0	7.20141
HCC1187	DepMap CRISPR Gene Dependency	1.0	2.51843
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BPH1	DepMap CRISPR Gene Dependency	1.0	2.3604
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.843776
DCAF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60371
QX 314	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14113
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421145
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Myeloid leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Acute myeloid leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Galloway-Mowat syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.561
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516605
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74889
LIPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85294
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.01533
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Prognosis_NOT_Tumor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77178_2_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HMS3745G19	DeepCoverMOA Drug Mechanisms of Action	1.0	0.53
Intrinsic component of cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721939
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nephrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.08
GW 501516	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450487
GSE220520_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ribonuclease MRP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CNTROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01598
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC163	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05147
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ro 48-8071	DeepCoverMOA Drug Mechanisms of Action	1.0	0.51
archaeal-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.998
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233562
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4106
KKU100	DepMap CRISPR Gene Dependency	1.0	5.71698
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3911
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04831
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20614
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9427_TUBGCP4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.552544
ZCRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15567
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Celastrol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.3
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6719
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
D423MG	DepMap CRISPR Gene Dependency	1.0	5.74203
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
HT144	DepMap CRISPR Gene Dependency	1.0	3.3031
PMC7927818-AAC.01755-20-s0002.xlsx-Supplemental_Table_1-Supplemental_Table_1_List_of_significantly_altered_genes_in_MDMs_differentiated_in_the_presence_of_PrEP_FTC_v_No_Drug_TDF_v_No_Drug_FTC_v_TDF_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0642
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.79844
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ncih727	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3607
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.584
LSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68111
PMC12804025-mmc2.xlsx-LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Finasteride	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEp-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.629
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.933
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.425613
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.713666
IALM_LUNG	CCLE Cell Line Proteomics	1.0	4.2691
GSE220613_0_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoid cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MM253	DepMap CRISPR Gene Dependency	1.0	2.01234
tRNA threonylcarbamoyladenosine metabolic process	GO Biological Process Annotations 2023	1.0	null
Moxonidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12028
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Podocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.619
PTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01793
CD-10-LX95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2387
ONDA9	DepMap CRISPR Gene Dependency	1.0	4.87543
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TXNDC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02391
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU387	DepMap CRISPR Gene Dependency	1.0	3.91091
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.06074
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1395	DepMap CRISPR Gene Dependency	1.0	3.36041
UACC62_SKIN	CCLE Cell Line Proteomics	1.0	3.09482
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.12549
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EMC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645