association dataset threshold value standardized value pioglitazone_mus musculus_gpl1261_gds4413 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null m1Lim part of the midbrain reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46206 BRD-K12120581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39163 single-organism process GO Biological Process Annotations 2015 1.0 null BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903558 PF382 DepMap CRISPR Gene Dependency 1.0 4.48415 BRD-K90702747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50062 TMEM219 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64757 POLR2A ENCODE Transcription Factor Targets 1.0 null KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NRSF MotifMap Predicted Transcription Factor Targets 1.0 null novobiocin-4569 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.072585 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS6KA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41856 molecular_function GO Molecular Function Annotations 2015 1.0 null CRCGN016_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.389 Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.977 BICR22 CCLE Cell Line Gene Expression Profiles -1.0 -2.52161 ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6681 striatonigral neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.965496 BRD-K66865641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94808 H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of VPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03102 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49203165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02304 H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null serotonin-activated cation-selective channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.687 GMPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01986 Myenteric plexus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.727 BRD-A38066207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30377 superficial stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.49496 CAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77648 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 normal phenotype MPO Gene-Phenotype Associations 1.0 null Lipid metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.003 abnormal striatum morphology MGI Mouse Phenotype Associations 2023 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01493 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63408 superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.72559 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K75371115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90764 BRD-K52973286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28523 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.388 TET1 ChEA Transcription Factor Targets 1.0 null amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00662 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.921878 Glaucoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 ETV5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0737 GATA2 ChEA Transcription Factor Targets 1.0 null REST_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853438 DESI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30613 TRAPPC6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37116 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054816 GATA4_Deletion - for the second exon_GDS2316_712_mouse_Heart ventricles (of GATA4 animals heterozygous) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K96093221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1953 UT7 CCLE Cell Line Gene CNV Profiles 1.0 1.96706 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73087 NCIH1618 CCLE Cell Line Gene Expression Profiles 1.0 1.72385 Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AG-013608-5904 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39367 ELOVL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02999 14673169-TableA1-2 GeneSigDB Published Gene Signatures 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null abnormal striatum morphology MPO Gene-Phenotype Associations 1.0 null 496100646_TCx_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.38958 striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18359 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40722 Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.9205 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-4941-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K56179613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01978 CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6848 GSE145915_5_v_4_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.94945 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19897 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.267791 BRD-K22390389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10867 cytoplasmic side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.268237 H3K9me3_Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cerebral subcortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.032 tiotropium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2344 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.392 CRCGN015_HEPG2_48H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.60251 SMAD3-21741376-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51643 periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18297 PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_2_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 metaraminol-7368 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063705 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.979167 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19563 CRX-20693478-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K85977749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53655 NKAPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29678 Dentate gyrus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12152 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.230601 ZNF41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99376 FANCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67412 homeostatic process GO Biological Process Annotations 2015 1.0 null CRCGN009_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.14237 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.887778 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068937 submedius thalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19103 Nucleus lentiformis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.884 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UACC893 CCLE Cell Line Gene CNV Profiles 1.0 2.11218 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.026654 SLC12A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32761 H376 DepMap CRISPR Gene Dependency 1.0 2.20508 putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64286 H3K27me3_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4446-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 POTEI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90059 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.921749 BRD-K73524144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.37773 EZH2-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GALR3_FBS LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18147 receptor activity GO Molecular Function Annotations 2015 1.0 null H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null habenula (old epithalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27221 lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46206 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30033 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tegmentum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.238406 CRCGN014_HEPG2_24H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4804 NCI-H2009 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6041 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.151 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TIGAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94669 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.53353 Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20239 PROP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0983 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4845-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88117 Anxiety disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.725 abnormality of circulating fibrinogen GWASdb SNP-Phenotype Associations 1.0 0.534811 CCNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93669 REST_Panc1_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1694 CCLE Cell Line Gene Expression Profiles 1.0 1.74079 hsa-miR-548p TargetScan Predicted Conserved microRNA Targets 1.0 0.419947 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85232515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29634 Nervous System Diseases CTD Gene-Disease Associations 1.0 1.1753 Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28707 GSE99687_0_v_1_smad5_human RummaGEO Gene Perturbation Signatures 1.0 null GRIPAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53713 lateral septal nucleus, intermedio-dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09103 HOKUG DepMap CRISPR Gene Dependency 1.0 2.53478 GAK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92231 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901777 PRKAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80875 cellular calcium ion homeostasis GO Biological Process Annotations 2015 1.0 null CRCGN017_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59954 APEX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68043 RNA helicase p68_KD_GDS2152_626_mouse_skeletal muscle cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K07781799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13363 Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IM-95 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K91836330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02166 MFE-296 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-X4-A8KQ-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25081034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51221 Dentate gyrus, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01041 OSR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6762 abnormal associative learning MGI Mouse Phenotype Associations 2023 1.0 null corpus striatum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.688817 ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1114 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.984862 hippocampus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.38665 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.996254 H4K20me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null E2F5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24337 GM97 BioGPS Cell Line Gene Expression Profiles -1.0 -1.02748 BRD-K43159427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10527 neurological GAD High Level Gene-Disease Associations 1.0 0.293278 BRD-K78262424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3011 debrisoquin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20124 KDSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94234 Bed nuclei of the stria terminalis, posterior division, strial extension Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34075 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7469 CAPAN1 CCLE Cell Line Gene CNV Profiles -1.0 -2.48781 H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.2396 H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36239 Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 47.7765 pravastatin-lactone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.56923 Smc5-Smc6 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.327 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C4-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08988 Alcohol dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.152 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CREB MotifMap Predicted Transcription Factor Targets 1.0 null Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.268 SPI1-20517297-HL60-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K93023309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40182 CHD1 ENCODE Transcription Factor Targets 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GPR120_KO_GDS4830_414_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K99690279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36544 BRD-K46999092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40046 extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.268237 BRD-K44858727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06549 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234289_5_v_2_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5358 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2371 superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13637 septopallidal transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63889 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10735 Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04943 BRD-K41538715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96828 G protein-coupled receptor homodimeric complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.772 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.393 hsa-miR-106b TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 JUN ENCODE Transcription Factor Targets 1.0 null OGFOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53959 GSE126345_9_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null Habenular trigone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.341 Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARMC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98147 BRD-K92291448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21951 CRCGN017_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.04545 STMN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90191 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.08288 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16355056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31762 CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.91887 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TX-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIP4K2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6392 dorsolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.841192 Cholinergic neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.079 496100640_PCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.52909 hsa-miR-520c-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null glycine-tRNA ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.995 SNX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54674 presence GeneRIF Biological Term Annotations 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847868 BRD-K66559139 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69942 PDE10A_KO_GSE40377_581_mouse_Striatum and hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hsa-miR-211 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 REST_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17597811-SuppTable7 GeneSigDB Published Gene Signatures 1.0 null HEC1B DepMap CRISPR Gene Dependency 1.0 2.47055 CRCGN016_MCF10A.TP53.M_24H:E21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.78529 PA2G4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11414 RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 2.65131 REST_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intrinsic component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48983 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37721 PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49628278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12723 Ventral globus pallidus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.3 BRD-K97209864 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80283 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12345912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15783 BRD-K96377358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08696 CRCGN011_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.062 ERG-21242973-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null MAZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34179 BRD-K60946512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09564 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of metabolic process GO Biological Process Annotations 2025 1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7948-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ORC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38681 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847868 RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE234289_4_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null Lateral terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17987 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null FOSL1::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3093 superficial stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86227 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.15123 MTF2-20144788-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Atherosclerosis_Aorta Smooth Muscle Tissue_GSE420 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.2691 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55611 BRD-K60794504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1136 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2207 BRD-K97943226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35708 17597811-SuppTable9 GeneSigDB Published Gene Signatures 1.0 null regulation of biological process GO Biological Process Annotations 2015 1.0 null ERG-21242973-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF385B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6281 H3K9me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Seizures CTD Gene-Disease Associations 1.0 1.18554 Field CA3, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11151 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ICC8 DepMap CRISPR Gene Dependency 1.0 2.95882 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.59083 NARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4741 MEL-HO GDSC Cell Line Gene Expression Profiles -1.0 -1.80022 narcolepsy GAD Gene-Disease Associations 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null arecoline-5423 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EZH2-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K57490754 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07337 GSE144231_4_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Field CA2, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19307 KU812 CCLE Cell Line Gene CNV Profiles 1.0 1.61643 BRD-K45928581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98956 BRD-K75887263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19873 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1639 anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14225 BRD-K58333451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76088 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KPNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34635 Acromelic frontonasal dysostosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 nulliscc1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.366 PSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00797 REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18620798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00492 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 1.05763 SUZ12-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LPCAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6228 PRKAR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79562 BRD-K38955287 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01227 Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1-20566737-PRIMARY-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Bed nuclei of the stria terminalis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06747 BCL11B_KO_GDS3178_296_mouse_striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849931 SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.87025 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36401 GSE79663_2_v_0_tcf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null pallidal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54334 BRD-K16715205 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86468 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40257 Kidney renal papillary cell carcinoma_KIRP_TCGA-EV-5903-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72787 U266B1 CCLE Cell Line Gene CNV Profiles -1.0 -1.72367 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null BATF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24479 BRD-K65598536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1804 BRD-K64860758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0982 integral component of plasma membrane GO Cellular Component Annotations 2015 1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.834972 SUPT1 DepMap CRISPR Gene Dependency 1.0 3.21752 Amygdala BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55362 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.731664 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null foam cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.255234 TMEM265 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58542 REST_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebral hemisphere TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.783972 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.1538 BRD-K06614664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02498 EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.82838 CRCGN012_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05961 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A439-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null avian pallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.093663 Epithalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.22 polymorph layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41914 Pons BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.08918 superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18022 LB647-SCLC GDSC Cell Line Gene Expression Profiles 1.0 1.98254 POC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51569 MSTO211H DepMap CRISPR Gene Dependency 1.0 3.92457 BRD-K87743988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2738 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64421 BRD-K09511124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67101 Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35146 Secretory trichome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.028 positive regulation of cytosolic calcium ion concentration GO Biological Process Annotations 2015 1.0 null HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4149 CORL88 CCLE Cell Line Gene Expression Profiles 1.0 1.90628 GSE138001_5_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null divalent inorganic cation homeostasis GO Biological Process Annotations 2015 1.0 null BRD-K35132745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77467 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.149 Brain Lower Grade Glioma_LGG_TCGA-CS-4942-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.929744 Inflammation CTD Gene-Disease Associations 1.0 1.49356 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null FMN reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.734 corticoid layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71875 CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.04065 HDAC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1341 EPS15L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85218 BRD-K19269952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09159 RUNX3 ENCODE Transcription Factor Targets 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.22148 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.08325 ADCY5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21864 C1orf116 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82576 CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 rostral putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.13903 SEMA4F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88463 ZNF410 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14693 NCI-H2227 COSMIC Cell Line Gene Mutation Profiles 1.0 null ES-WA7 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.25316 CD200 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55404 dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29202 BRD-K71947697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52595 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF Rummagene Transcription Factor Associations 2026 1.0 null TWSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50776 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.197 MYB_01_44 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.65264 CRCGN015_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.80261 ChIP_SUZ12_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H1-7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99308 Rheaume et al.Nat Commun.37_Retina_Mouse CellMarker Gene-Cell Type Associations 1.0 null RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1126 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23461 Metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.522185 BRD-K68036990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22701 BRD-K73462370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56281 ETS2_KD_GSE62168_259_mouse_mouse trophoblast stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.12043 hsa-miR-520a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.552 Perturb_10442_KO_Zfhx3_SRP187824 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 18.585 FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3086 BRD-K63263229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05215 intermediate stratum of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46206 C6orf136 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29831 Separation anxiety disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 OCILY19 CCLE Cell Line Gene CNV Profiles -1.0 -1.39225 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00119 17597811-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null intermediate stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49139 BRD-K97746859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07841 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.57503 PARP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61415 dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.865191 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.936 UBB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58903 BRD-K15393664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03682 BRD-K14041149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73865 TPBGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26607 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4789-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 NCIH889 CCLE Cell Line Gene Expression Profiles 1.0 1.36727 RALGAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83676 RIOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14777 ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0756 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-200a TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 Narcolepsy HuGE Navigator Gene-Phenotype Associations 1.0 null Cognition Disorders CTD Gene-Disease Associations 1.0 1.21567 H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null periventricular stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06667 BRD-K12986105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69179 SIN3B ChEA Transcription Factor Targets 1.0 null superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51015 HCC202 DepMap CRISPR Gene Dependency 1.0 2.71699 abnormality of the common coagulation pathway GWASdb SNP-Phenotype Associations 1.0 0.534811 BRD-K59239787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22848 Peripheral Nervous System Diseases CTD Gene-Disease Associations 1.0 1.08196 E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 496100565_FWM_probable Alzheimer's disease_TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19132 H3K9me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.85344 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tegmentum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.495 frontalcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.051152 BRD-K62229896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.32808 Basal ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.179 ASB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58364 USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72399 chemical homeostasis GO Biological Process Annotations 2015 1.0 null BRD-K46413323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96223 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.58113 rostral subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0018 Hand1::Tcf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.6207 MYC ChEA Transcription Factor Targets 1.0 null BRD-K59087082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33973 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19924 HDH_CAG knock-in_GDS3935_569_mouse_Striatum and cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null no abnormal phenotype detected MPO Gene-Phenotype Associations 1.0 null 496100625_FWM_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.3032 SEC31B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25044 SNU1077 CCLE Cell Line Gene Expression Profiles -1.0 -1.62981 Field CA1, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37709 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35251 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles -1.0 -1.54603 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K73387470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.18362 SNU601 DepMap CRISPR Gene Dependency 1.0 3.05176 LAMTOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82828 LZTS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45469 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4475 RNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92939 hsa-miR-1271 TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 nicotinic acid-6702 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cd4.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.00148 REST_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.125 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 19074878-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null NCIH1299 CCLE Cell Line Gene CNV Profiles 1.0 1.40084 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null NUTM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9786 KAP1-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN014_HEPG2_24H:D10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10537 ZNF175 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.435 DMAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10289 CRCGN016_MCF10A.WT.HP_24H:C08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.36166 IFT57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11949 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.960002 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68401 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN Rummagene Transcription Factor Associations 2026 1.0 null SARS-dORF6_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.78994 Prenatal Injuries CTD Gene-Disease Associations 1.0 1.01587 hsa-miR-519d TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 mantle zone of CA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44466 ZC3H14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35068 BRD-K19272295 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31823 NCIN87 CCLE Cell Line Gene Expression Profiles -1.0 -1.4517 KURAMOCHI CCLE Cell Line Gene Expression Profiles -1.0 -2.53202 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051261 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COX7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 SNAI2_01_292 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.35245 Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.8185 accumbens nucleus, shell domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49325 CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.52475 THNSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3391 DU4475 CCLE Cell Line Gene CNV Profiles -1.0 -1.75889 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039366 Lateral ventricle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.534 Acute Myeloid Leukemia_LAML_TCGA-AB-2886-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null retroreuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06304 SNU423 CCLE Cell Line Gene CNV Profiles 1.0 1.52511 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040372 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DFFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03951 Ammon's horn Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38952 Lateral septal complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10355 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20860821-TableS5 GeneSigDB Published Gene Signatures 1.0 null BRD-K82508779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79008 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KM-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12115687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01566 BRD-K38417094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02352 HCMV_TB40E_24Hour_19951172_GSE14816 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.06576 Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 TMA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 BRD-K35288606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39792 Circular smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 BHLHE40 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.1273 cellular metal ion homeostasis GO Biological Process Annotations 2015 1.0 null SBC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42277 H3K27me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15911 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069649 GABRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99516 SUZ12-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.888 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNAJC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13568 BRD-K99681648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30435 Childhood electroclinical syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.82 Habenula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.429 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K58028568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91691 primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44495 HNRNPUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00588 Caudatenucleus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 BRD-K43336921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04324 Demyelinating disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.483 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BLZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5888 Diarrhea DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 CADOES1 CCLE Cell Line Gene Expression Profiles 1.0 2.73801 PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7259 CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1383 accumbens nucleus, core domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30121 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.02154 ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null model GeneRIF Biological Term Annotations 1.0 null BRD-K76960042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62404 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063695 BRD-K01237277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04332 CDK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07411 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.897589 SU-DHL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36239 BRD-K12886565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33251 BRD-K85418917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19541 dorsal endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10555 CHD7 ENCODE Transcription Factor Targets 1.0 null NCIH1836 CCLE Cell Line Gene Expression Profiles 1.0 2.22572 basal ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.699444 HRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37959 CRCGN008_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.26725 Field CA1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77951 KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08988 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.63718 Olfactory tubercle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.878 PIANP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17717 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H103 DepMap CRISPR Gene Dependency 1.0 2.01528 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54733 ECHDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1269 ventromedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14539 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE126345_9_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null Rotavirus infection of children_Peripheral blood mononuclear cell_GSE2729 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50964 BRD-K99516890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50508 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8837 BRD-K38929571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49723 Trichome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.137 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null Alzheimer's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.737 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.941073 KIF1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96801 BRD-K11433244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08598 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847868 KLF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8213 Field CA3, stratum lucidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40517 Type III polyketide synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.513 DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null abnormal learning/memory/conditioning MPO Gene-Phenotype Associations 1.0 null Synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.972 behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null BRD-K98224452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20071 BRD-K19227646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63643 NAA35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52684 mRNA_MYCN_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null ZBTB25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31552 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0506 TTLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03314 ITM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31665 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.77067 metabolic GAD High Level Gene-Disease Associations 1.0 0.295739 lateral septal nucleus, intermedio-intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22566 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2148 GPCRs, Class A Rhodopsin-like(Homo sapiens) WikiPathways Pathways 2014 1.0 null NCI-H2141 GDSC Cell Line Gene Expression Profiles 1.0 1.81685 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.540981 occipital lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.318407 SPI1-20517297-HL60-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.854539 H2AFZ ENCODE Transcription Factor Targets 1.0 null BRD-K87537204 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31982 REH COSMIC Cell Line Gene Mutation Profiles 1.0 null IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55004 BRD-K76521932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24142 Avian pallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.568 Pervasive developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.416 HCC202 CCLE Cell Line Gene CNV Profiles -1.0 -2.19419 cell part GO Cellular Component Annotations 2015 1.0 null plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.052388 BRD-K71169857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3922 CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2145 UNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75456 GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28028 VAESBJ DepMap CRISPR Gene Dependency 1.0 2.8162 Suprageniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23302 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67483 ChIP_REST_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRCGN012_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23597 REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.568775 hsa-miR-629 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE195663_0_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0743 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intrinsic component of plasma membrane GO Cellular Component Annotations 2015 1.0 null REST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84617 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_EZH2_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K36467636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29064 Epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.73 Medial geniculate complex, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20343 GATA2_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18253 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847868 BRD-K74107343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09812 g-protein coupled receptor signaling pathway GO Biological Process Annotations 2015 1.0 null Ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 RMGI DepMap CRISPR Gene Dependency 1.0 2.25406 ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8639 KMS-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lassa Fever Virus_8hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.00238 shear GeneRIF Biological Term Annotations 1.0 null parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07215 STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3716 CRCGN016_MCF10A.TP53.M_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39201 ZNF678 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34909 BRD-K16604405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89799 Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 ChIP_H3K27me3_20682450_humanESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null ZKSCAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33004 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.374666 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040712 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08043 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.95712 intermediate stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21188 NCI-H378 GDSC Cell Line Gene Expression Profiles 1.0 1.82088 SUZ12-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TET1-21490601-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.47121 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19124 OlfactoryBulb BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.884599 LN-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.72559 SUDHL8 CCLE Cell Line Gene CNV Profiles 1.0 2.41057 arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K92365616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64428 Olfactory tubercle, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55216 IGROV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K41972460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04665 BRD-K97263385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06093 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00945 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051385 JUN_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K55479099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17778 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84735 17597811-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null T-98 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.603 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0174 Upstream stimulatory factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.565 dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73038 vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055632 RUSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62171 ASB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63199 septopallidal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22322 Chronotype GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.952288 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K73427605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.555 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19467 Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60716223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49887 DNAJC2 ChEA Transcription Factor Targets 1.0 null hsa-miR-302d TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 PMC7770114__F7 PFOCR Pathway Figure Associations 2023 1.0 null KRT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99671 paraseptal subpallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58839 Leydig cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.061 FLI1 ChEA Transcription Factor Targets 1.0 null CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.842 abnormal nervous system morphology MPO Gene-Phenotype Associations 1.0 null ECPAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7001 RCCFG2 DepMap CRISPR Gene Dependency 1.0 3.12286 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FYTTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66816 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.82105 NCIH1395 CCLE Cell Line Gene CNV Profiles -1.0 -2.10754 dopaminergic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.773589 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25733 toxic encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.328105 HPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13422 hsa-miR-1 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 hsa-miR-302b TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.846459 GSE234289_5_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73290515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03625 TM-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.07 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CPCN CCLE Cell Line Gene Expression Profiles 1.0 2.15998 BRD-K15236933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46712 H3K27me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCIH358 DepMap CRISPR Gene Dependency 1.0 3.29547 CORL24 CCLE Cell Line Gene Expression Profiles 1.0 1.6896 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4737 CRCGN015_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.085 TBRG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47612 PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-e-Classification_of_camel_SON_basal_genes_-_G_protein_coupled_receptors_SON Rummagene Transcription Factor Associations 2026 1.0 null oxaliplatin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37062 BRD-K33787033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80286 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14051 BRD-K53046137 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.72741 posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.891664 REST_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BBX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43136 CRCGN017_MCF10A.WT.HP_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8534 SOLENGEPRAS DGIdb Drug Targets 2026 1.0 17.644 SUZ12-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33185 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FC-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.10462 REST_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_PFSK-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2029 GDSC Cell Line Gene Expression Profiles 1.0 2.02297 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.64515 CRCGN015_HEPG2_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.01959 Medial geniculate complex, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00115 hsa-miR-450b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.6293 COLO678 DepMap CRISPR Gene Dependency 1.0 2.55491 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07593 KRAS.AMP.LUNG_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null hsa-miR-520d-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 C10 DepMap CRISPR Gene Dependency 1.0 2.60046 GSE124932_2_v_1_sarm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null bemegride-3051 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -2.15802 hsa-miR-3619-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K85668200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19999 KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K46549154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28113 RAD21 ENCODE Transcription Factor Targets 1.0 null COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0174 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FP-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968339 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GL-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TFE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68062 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K02420839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12258 T3M4 BioGPS Cell Line Gene Expression Profiles 1.0 1.24203 BRD-K59683187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31456 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.18404 HERPUD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60822 superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46206 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47158 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAT DepMap CRISPR Gene Dependency 1.0 5.06878 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST-18959480-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09131 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49725 NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0976 STAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67922 Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DCAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46887 no abnormal phenotype detected MGI Mouse Phenotype Associations 2023 1.0 null GSE81803,GSE81912_3_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FLI1-21867929-TH2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null dorsolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.86066 vascular smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.12896 H3K9me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PHAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28471 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.75008 Absence epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.739 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31435 Perturb_16899_KO_Sp8/Sp9_SRP115902 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.2617 FU97 DepMap CRISPR Gene Dependency 1.0 6.52698 CRCGN017_MCF10A.WT.HP_24H:N23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5419 CRCGN011_HEPG2_24H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07595 INPP5F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93482 POLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59349 SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR Rummagene Transcription Factor Associations 2026 1.0 null UBTFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22889 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45475 CRCGN015_HEPG2_48H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96486 superficial stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5424 TRIM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45218 hsa-miR-613 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 2.81334 DARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59513 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.955 BATF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5133 SULT1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11071 ELK1::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9444 JUN::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9862 OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02994 GTPBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57506 THP1 CCLE Cell Line Gene CNV Profiles 1.0 1.76886 lmx1b_18351676_hind_limb_bud_lof_mouse_gpl1261_gds3320 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.026766 medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.967093 transmembrane signaling receptor activity GO Molecular Function Annotations 2015 1.0 null HOMEZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11931 BRD-K69671285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61841 THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11415 subpallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61515 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59442 anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.82896 CRCGN014_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21687 BRD-K15794956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54504 Bipolar disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.459 GSK3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48169 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04239 RARB-27405468-CHIP-SEQ-BRAIN-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Autoimmune disease of the nervous system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.457 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.276 hsa-miR-4291 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 BRD-K69423881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27653 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SLC1A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02413 hsa-miR-302e TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 TESMIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89093 SPSB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53727 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.75924 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09046 CRCGN008_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4498 SMAD3-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948994 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.11408 dorsalstriatum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.34648 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1208 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A199-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KP2 CCLE Cell Line Gene CNV Profiles -1.0 -1.32966 PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null L428 CCLE Cell Line Gene CNV Profiles 1.0 1.5505 intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.048052 BRD-K42987166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27078 Learning Disorders CTD Gene-Disease Associations 1.0 1.57759 BICR6 DepMap CRISPR Gene Dependency 1.0 2.0121 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Striatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69714 BRD-K38975326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90797 RELT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74122 TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -2.1884 NCI-H209 GDSC Cell Line Gene Expression Profiles 1.0 2.26723 NANOG-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Prestwick-1080-4532 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LUZP1-20508642-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ETV4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1473 bleomycin-sulfate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93296 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me3_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H2126 COSMIC Cell Line Gene Mutation Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.50942 ZNF74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31935 Hippocampal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38649 mantle zone of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53383 NRBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20808 Nucleus accumbens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85679 CRCGN016_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98154 GSE156907,GSE160237_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null RETREG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55011 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mesocorticolimbic dopaminergic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.872 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27609 DDX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30875 SEMA4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22196 NASH_Liver_GSE24807 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.45914 ARTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20042 laterostriatal stripe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65366 Substance abuse DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.387 BRD-K38694430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31916 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10883 TGIF2LX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0459 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN Rummagene Transcription Factor Associations 2026 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9617 MYL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57727 FOXO3 ChEA Transcription Factor Targets 1.0 null TRAFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57853 REST_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33935 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE144231_6_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Enteric plexus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.717 microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54434 H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11228 medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882476 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30226 GNRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92491 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.546 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.04755 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49694 COR-L88 GDSC Cell Line Gene Expression Profiles 1.0 1.86978 SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4623 PPP1R7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16213 Multiple sclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.49 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.80501 SRSF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.21403 HCC33 CCLE Cell Line Gene Expression Profiles 1.0 1.64306 Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INTS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33066 H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05015930 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22455 TMEM104 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94861 NANOG ChEA Transcription Factor Targets 1.0 null CRCGN016_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1875 NAPRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67408 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Subpallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.855 H2AC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52059 496100426_PCx_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6014 TET1-21490601-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HEY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75274 TE8 CCLE Cell Line Gene Expression Profiles -1.0 -2.70147 BACH1 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.28714 polymorph layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53075 hsa-miR-2114 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 BRD-K31834149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38166 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-2W-A8YY-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61691014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69253 GSE81803,GSE81912_4_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Striatonigral neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.946 REST_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHT101 DepMap CRISPR Gene Dependency 1.0 2.45816 Crus 2, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2422 BRD-K23467057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16623 Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 r1 part of intermediate nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3911 ICC9 DepMap CRISPR Gene Dependency 1.0 3.03721 Caudoputamen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.02732 hsa-miR-4287 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MGAT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09023 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.838484 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33817 Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RXRA ENCODE Transcription Factor Targets 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null CREBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5563 CRCGN008_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.314 PARP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03587 Crohn Disease HuGE Navigator Gene-Phenotype Associations 1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E7-01A-31R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50906 MFE280 CCLE Cell Line Gene CNV Profiles 1.0 1.37103 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-373 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 hsa-miR-761 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 VDR-24787735-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K61924932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09782 Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K25768791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23819 vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044928 BRD-K03765511 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4484 temporal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.47348 Non-odorant GPCRs(Mus musculus) WikiPathways Pathways 2014 1.0 null CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K59045095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11497 BRD-K33268483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11593 biological regulation GO Biological Process Annotations 2015 1.0 null DUSP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41647 hypothalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098417 RPMI2650 DepMap CRISPR Gene Dependency 1.0 2.24581 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.603 HMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57361 PDCD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00549 Lateral septal nucleus, rostral (rostroventral) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17882 NDUFS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38609 MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9476 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.912507 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.2107 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43723 CDK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96296 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null RDES DepMap CRISPR Gene Dependency 1.0 4.54767 REST_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.937941 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039316 KMS21BM CCLE Cell Line Gene Expression Profiles 1.0 1.49682 control GeneRIF Biological Term Annotations 1.0 null molecular layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94721 corticoid layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61129 ELF1 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A465-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RSPO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61179 post-traumatic stress disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.376 Parathyroid hormone secreting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.583 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31624 BRD-K13839731 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28927 ST14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59268 Electroclinical syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.713 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.544152 Photoreceptor distal connecting cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.72 PYGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84002 Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24312 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SDF2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87546 TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null REST_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16525290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52365 H3K27me3_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0696 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.4965 SNU685 CCLE Cell Line Gene Expression Profiles -1.0 -1.66645 SNX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88386 Tic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 KDM4A ENCODE Transcription Factor Targets 1.0 null PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96033 BRD-K67177501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54681 H3K27me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null REST_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01009153 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47183 sphingosine-1-phosphate receptor activity GO Molecular Function Annotations 2015 1.0 null BMI1-23680149-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Autistic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 BRD-K53936012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03141 SNU213 CCLE Cell Line Gene Expression Profiles -1.0 -1.74579 signal transducer activity GO Molecular Function Annotations 2015 1.0 null Primary dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.964 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78616 H3K9me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inner CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.856269 parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.241546 mRNA_OTX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SMAD3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.40347 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KMT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38019 TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7993 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.938873 INHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63332 DNAJC2-21179169-NT2-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BLTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17486 Y79 DepMap CRISPR Gene Dependency 1.0 4.19584 Field CA3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13549 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.260267 body of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.61828 CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63325 Cerebral nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5498 GSE145915_3_v_4_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K61520618 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30643 BRD-K78826848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32157 NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Attention deficit hyperactivity disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.305 CRCGN010_HEPG2_24H:A08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19765 Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU1327 DepMap CRISPR Gene Dependency 1.0 2.53821 striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26192 BRD-K62236460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36805 integral component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 OCIMY7 DepMap CRISPR Gene Dependency 1.0 3.76506 Cortical amygdalar area, anterior part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15922 KLM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.93809 RCOR3-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Atherosclerosis CTD Gene-Disease Associations 1.0 1.10562 GGT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20646 SK-N-DZ GDSC Cell Line Gene Expression Profiles -1.0 -1.54902 intermediate stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21055 HDAC2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04177 KLF5_KO_GDS3509_553_mouse_ES cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null granule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.478534 CRCGN017_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79875 INSIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9587 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1801 Endopiriform nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05111 Pallidum, caudal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06562 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAAP24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90451 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP110 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37212 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10251 Pars reticulata TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.679 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.893096 BRD-K95860374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86265 TNFRSF21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46944 Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08635 signal transduction GO Biological Process Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LI7 DepMap CRISPR Gene Dependency 1.0 2.1536 CRCGN011_HEPG2_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9292 Brain Lower Grade Glioma_LGG_TCGA-DB-A64L-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal part of alar p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27348 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6Y9-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60777 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K59821747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04917 ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12141 SNUC2A CCLE Cell Line Gene CNV Profiles 1.0 1.50337 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 BRD-K68303333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2707 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Habenular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.341 BRD-A13983189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17568 VRK1_knockout_64_GSE19329 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.91851 RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49694 TRIO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88726 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null HNF1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2763 16740756-Table2 GeneSigDB Published Gene Signatures 1.0 null BRD-K73834056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27047 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91853 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SLC41A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33273 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QR-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.94125 BRD-K04771555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17828 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.913418 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM47E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44114 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02065 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09447 Field CA2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12239 NCIH1648 CCLE Cell Line Gene CNV Profiles 1.0 1.98586 REST_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K97485956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01833 BRD-K92399035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68941 large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.054294 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32947579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4635 SMAD3 ChEA Transcription Factor Targets 1.0 null fluid GeneRIF Biological Term Annotations 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069805 ADAM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80357 HOXB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.1816 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.996849 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN Rummagene Transcription Factor Associations 2026 1.0 null NCIH1623 CCLE Cell Line Gene CNV Profiles -1.0 -1.92382 aminoacyl-tRNA synthetase multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 SPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5917 REST_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.732265 NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9819 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MRPS18B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28162 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.836289 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null reticular formation of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02308 CRCGN010_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4029 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^4_None_GSE44441 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.02731 side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.140189 SLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38048 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04179 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.14922 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K96547094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41182 ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8219 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral septal nucleus, intermedio-ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05767 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039219 CREB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58456 ChIP_H3K27me3_18600261_mouseWholeBrain ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TMD8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33185 BRD-K04508260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40395 lateral terminal nucleus of the accessory optic tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33687 metal ion homeostasis GO Biological Process Annotations 2015 1.0 null central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.777325 Calcium HMDB Metabolites of Enzymes 1.0 null lateral septal nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10237 periventricular stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64122 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00011 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Process Annotations 2025 1.0 null cytosolic calcium ion homeostasis GO Biological Process Annotations 2015 1.0 null regulation of biological quality GO Biological Process Annotations 2015 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 sphingosine-1-phosphate signaling pathway GO Biological Process Annotations 2015 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DICER1_KO_GDS4504_585_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null JHH1 DepMap CRISPR Gene Dependency 1.0 3.60245 REST_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 5.86343 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06649 ZBED2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2938 DKMG CCLE Cell Line Gene CNV Profiles -1.0 -1.35875 GTF2F1 ENCODE Transcription Factor Targets 1.0 null CCNQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80697 CA SKI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0017 RXR-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SK-N-FI COSMIC Cell Line Gene Mutation Profiles 1.0 null anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17506 Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma membrane part GO Cellular Component Annotations 2015 1.0 null FOXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89058 MAP2K7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95595 CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.23256 BRD-K68257399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05174 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAB22A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07979 REST ChEA Transcription Factor Targets 1.0 null NCIH2029 CCLE Cell Line Gene Expression Profiles 1.0 2.95617 PIK3CD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26705 SBDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86424 PEO4 DepMap CRISPR Gene Dependency 1.0 2.0287 STRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57663 rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.521 MAVER1 DepMap CRISPR Gene Dependency 1.0 3.7237 GSE144231_2_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.976689 influences GeneRIF Biological Term Annotations 1.0 null STAT3_deficiency_GDS3106_58_mouse_type II alveolar cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31292 striatal septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03947 HCC38 CCLE Cell Line Gene Expression Profiles -1.0 -1.62177 superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17581 H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ISOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94197 outer CP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08607 REST_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8HJ-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843635 REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA1, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11406 CTBP2 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 USF1 ENCODE Transcription Factor Targets 1.0 null SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mRNA_SMAD1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040116 horizontal nucleus of the diagonal band, transitional part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1004 FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null PRSS53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94571 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K01212001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56147 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.992976 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Serotonergic neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.751 SMARCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14499 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.82276 TRIM28 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68086276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11196 MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.258 medial amygdala, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00331 CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.62482 UBE2F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62849 PTGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30306 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05093 ChIP_MTF2_20144788 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null bed nucleus of the external capsule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19126 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ChIP_EED_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SNU601 CCLE Cell Line Gene CNV Profiles 1.0 1.57771 hsa-miR-4793-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE149096_4_v_3_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67549 ZNF143 ENCODE Transcription Factor Targets 1.0 null TSPYL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5839 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08473 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5694-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K90686617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0233 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K84802956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51387 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047944 CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2996 fallopian tube GTEx Tissue Gene Expression Profiles -1.0 -2.1002 MXI1 ENCODE Transcription Factor Targets 1.0 null 496100469_TCx_no dementia_TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6971 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.82365 REST_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null stress GeneRIF Biological Term Annotations 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0768 Complement component C1q complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.289 PATL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67096 ESR1 JASPAR Predicted Transcription Factor Targets 1.0 null abnormal behavior MPO Gene-Phenotype Associations 1.0 null Perturb_1060_Mut_Esr1_SRP087718 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.15572 NCIH2141 CCLE Cell Line Gene Expression Profiles 1.0 1.98648 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.996254 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dentate gyrus, granule cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11905 NET1_KD_GDS4196_436_human_AGS - gastric adenocarcinoma cells - (63 shRNA Knock-Down) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09666 external globus pallidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68353 hsa-miR-769-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 PCM6 CCLE Cell Line Gene CNV Profiles -1.0 -1.42151 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01187 TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2766 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null bioactive lipid receptor activity GO Molecular Function Annotations 2015 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40334 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sphingosine 1-phosphate Guide to Pharmacology Chemical Ligands of Receptors 1.0 null dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.950158 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09893 GSE94814_2_v_3_reck_mouse RummaGEO Gene Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82648 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.2379 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-214 TargetScan Predicted Conserved microRNA Targets 1.0 0.32519 BRD-K73042446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02968 Claustrum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04198 SNU738 DepMap CRISPR Gene Dependency 1.0 2.69511 BRD-K45717258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49422 DNAJB14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21288 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.25239 Liver hepatocellular carcinoma_LIHC_TCGA-K7-A5RG-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84958 Neural Tube Defects CTD Gene-Disease Associations 1.0 1.22534 CHRNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08401 REST_Panc1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.406 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null caudate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78144 ZNF592 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58352 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21147 Substantia innominata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11615 ERG ChEA Transcription Factor Targets 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.887778 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K83935370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24873 BRD-K44177046 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76092 EXAMPLE 494 [WO2014028479] PARENT MOLECULE DGIdb Drug Targets 2026 1.0 17.644 MRPS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86232 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41377 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Process Annotations 2025 1.0 null CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7952 SOX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33137 abnormal telencephalon morphology MPO Gene-Phenotype Associations 1.0 null H3K9me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30729 hippocampus (cortex Ammonis) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44634 WRNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02755 L428 DepMap CRISPR Gene Dependency 1.0 3.08874 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.936058 RNA helicase p68_KD_GDS2152_625_mouse_skeletal muscle cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K97939219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81083 retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.986633 MSTO-211H GDSC Cell Line Gene Expression Profiles -1.0 -1.88903 SEMA6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50898 NCIH510 CCLE Cell Line Gene CNV Profiles -1.0 -2.31681 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25461 cellular ion homeostasis GO Biological Process Annotations 2015 1.0 null septopallidal shell area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7571 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10986 BRD-K55399138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46064 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21847 SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 1.72963 KSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36967 Pallidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02167 BRD-K85622666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07333 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53485 medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20514 PDE10A_KO_GDS4542_292_mouse_hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ADD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3249 LAMA84 CCLE Cell Line Gene CNV Profiles 1.0 1.81489 MAZ ENCODE Transcription Factor Targets 1.0 null NCO2 CCLE Cell Line Gene CNV Profiles 1.0 2.00806 REST_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BAIAP2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68041 INTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66063 TANGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00308 H2BK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02322 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.394 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null NALM-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null FNDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83312 hsa-miR-204 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4103 CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K72146456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26407 pallidal islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42266 BRD-K37850190 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16556 496100348_TCx_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.47652 ChIP_SUZ12_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE218580_1_v_5_fentanyl_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K77953978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45053 A253 GDSC Cell Line Gene Expression Profiles -1.0 -1.46675 superficial stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29176 CRCGN016_MCF10A.TP53.M_24H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64543 obsessive-compulsive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.488 RGP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83904 EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61248288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39972 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.742 RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6697 BRD-K47984776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66021 CRCGN010_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51683 PTF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55654 G protein-coupled receptor activity GO Molecular Function Annotations 2023 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebral lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.610138 HEK-293 PEAKrapid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.777 intermediate stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02243 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XM-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP53I11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14801 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CBLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3936 NCIH1092 CCLE Cell Line Gene Expression Profiles 1.0 1.39273 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88534 periventricular stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00666 plasma membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NANOG-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Pain agnosia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.37 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76119 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null sphingolipid mediated signaling pathway GO Biological Process Annotations 2015 1.0 null nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22499 UACC812 CCLE Cell Line Gene Expression Profiles -1.0 -1.55413 BRD-K42679620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57799 H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF570 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58983 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.783876 M059K CCLE Cell Line Gene CNV Profiles 1.0 1.7592 H3K9me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16919 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33185 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUCLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02603 CDH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.755 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.968315 SIX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7545 ZNF77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92851 ADAMTS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02277 BRD-K35792251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4549 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 UBXN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17196 BACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6649 JHUEM3 CCLE Cell Line Gene Expression Profiles -1.0 -1.74836 FOXS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35934 Nape TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.282 KMS27 CCLE Cell Line Gene CNV Profiles -1.0 -1.76753 PRADC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32698 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.4657 septodiagonal transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16867 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Substance dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.278 subpallial septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08117 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.932228 neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.122609 mantle zone of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23643 mantle zone of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63716 BRD-K70039231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69034 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null signaling receptor activity GO Molecular Function Annotations 2015 1.0 null GSE126345_7_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null Wnt-Frizzled-LRP5/6 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.994 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HJ-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDX2-21402776-INTESTINAL-VILLUS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K81501934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63109 Field CA3, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21093 RET CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61594 ChIP_NANOG_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PCDHGC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49595 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.85074 Globus pallidus, external segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15535 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.851144 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27295 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.996254 BRD-K47049026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13681 BRD-K95678449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53727 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO-741 GDSC Cell Line Gene Expression Profiles -1.0 -1.44245 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nitrofurantoin-3674 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null periventricular stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30425 HDAC2 ENCODE Transcription Factor Targets 1.0 null GSE138001_2_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null NUP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37704 BRD-K28195874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53959 Dorsal raphe nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.642 SLC11A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49003 IGF1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53277 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57911 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null learning GeneRIF Biological Term Annotations 1.0 null SFTPC_KO_GSE35989_48_mouse_lung (type II cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null limbic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.390421 RNF103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03498 PTGES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63084 cellular cation homeostasis GO Biological Process Annotations 2015 1.0 null Dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 ANKRD33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60958 ACSM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81546 DMS79 CCLE Cell Line Gene Expression Profiles 1.0 1.84425 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7793-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.971345 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.033 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stria terminalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.793 BRD-K70379342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88058 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09665 RBBP5 ENCODE Transcription Factor Targets 1.0 null lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829212 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null diencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065971 Proteinuria CTD Gene-Disease Associations 1.0 1.02188 BRD-K43381631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44743 TLX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4253 kidney GTEx Tissue Gene Expression Profiles -1.0 -1.11389 ZNF479 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9709 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.32905 BRD-K27529556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20878 Huntington's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.686 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GJ-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.828518 SLC26A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05019 all GWASdb SNP-Phenotype Associations 1.0 0.028386 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.80899 CRCGN017_MCF10A.WT.HP_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.491 NCI-H1048 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K75807319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16625 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.903079 bioactive lipid receptor activity GO Molecular Function Annotations 2023 1.0 null RCOR3 ChEA Transcription Factor Targets 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null BRD-K51448234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50683 BRD-K60799989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30287 CLIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00898 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02608 substance-related disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.512 MT-ND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7337 ZNF354C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33716 REST MotifMap Predicted Transcription Factor Targets 1.0 null KIAA1522 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94048 APLP2_KO_GDS4414_371_mouse_prefrontal cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.05237 PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0281 hsa-miR-4685-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 KMS34 CCLE Cell Line Gene Expression Profiles 1.0 1.39657 SPI1 ChEA Transcription Factor Targets 1.0 null LGALS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90024 Dopaminergic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.485 Medium spiny neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.928 colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.200331 BRD-K63107801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15596 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.4 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.8319 hsa-miR-142-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.419947 temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01102 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K71452126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9266 shell of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00666 RAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21296 CCSW1 DepMap CRISPR Gene Dependency 1.0 3.50155 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20529 island of Calleja major Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.29548 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_SMAD7_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null striatum_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.17731 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050619 SLC15A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54836 CHD2 ENCODE Transcription Factor Targets 1.0 null HCC366 CCLE Cell Line Gene Expression Profiles -1.0 -1.5181 Hippocampus minor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.634 IZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867772 hsa-miR-2355-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00824 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-17 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 BRD-K09863466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11601 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07165 NCIH2106 CCLE Cell Line Gene Expression Profiles 1.0 1.76913 ETV3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8979 Infantile parkinsonism-dystonia 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11808 RNFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1135 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.846939 Prostate adenocarcinoma_PRAD_TCGA-J4-A6G1-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE138001_0_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null Serotonin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.825 REST_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8252 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.954693 morphine_mus musculus_gpl6246_gse17731 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RERF-LC-FM COSMIC Cell Line Gene Mutation Profiles 1.0 null ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ERF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.398 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC Rummagene Transcription Factor Associations 2026 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal brain morphology MPO Gene-Phenotype Associations 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K17061569 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27829 CAMLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83653 SSNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18739 WDR81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3039 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 Weight Loss CTD Gene-Disease Associations 1.0 1.06698 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67483 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rate GeneRIF Biological Term Annotations 1.0 null Get-1_Deficiency_GDS2629_161_mouse_embryonic skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null JcP contribution to LTL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.49496 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.982702 hsa-miR-4269 TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 SUPM2 DepMap CRISPR Gene Dependency 1.0 2.59045 BRD-K13038935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.39691 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.976452 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46185 DIFI DepMap CRISPR Gene Dependency 1.0 2.24248 AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K07836769 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14192 mRNA_ASCL1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null mantle zone of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03947 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.911448 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.914897 Medial habenular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.183 diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.4107 CEBPB ENCODE Transcription Factor Targets 1.0 null P2RY11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07334 APLP2_KO_GDS4414_534_mouse_adult cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null periventricular stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78067 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46117 Field CA1, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71783 SYT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60114 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF Rummagene Transcription Factor Associations 2026 1.0 null PMC6930440-jcav11p0520s3.xlsx-MI_vs_FG-Unnamed_0_MITF Rummagene Transcription Factor Associations 2026 1.0 null Memory Disorders CTD Gene-Disease Associations 1.0 1.36247 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTF2-20144788-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ChIP_RNF2_22325148 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19232 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051068 SIN3A ENCODE Transcription Factor Targets 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842406 Escherichia coli infection of the central nervous system_CNS - Brain (MMHCC)_GSE3253 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.5317 Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.839 TUBA1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40287 BRD-K27172015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22624 G protein-coupled receptor 6 InterPro Predicted Protein Domain Annotations 1.0 null OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55498 H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IFI6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23465 CCDC77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3101 CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.10455 membrane part GO Cellular Component Annotations 2015 1.0 null H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R7-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49918 MYH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69273 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35308744 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41504 Field CA1, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43943 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null MYC-19915707-AK7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.985708 GSE108675_3_v_0_slc1a4_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K62497619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05311 CRCGN012_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08745 BRD-K24156533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.69301 EXAMPLE 31 [WO2018183145] DGIdb Drug Targets 2026 1.0 17.644 ZC3H12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26965 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null vascular GeneRIF Biological Term Annotations 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 cellular chemical homeostasis GO Biological Process Annotations 2015 1.0 null MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 1.53031 PTPN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56533 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12787 HDAC2_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.5363 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24929039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52847 BRD-K38665228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31533 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.867 NANOG-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K25363217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03321 BRD-K59078001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05602 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.37591 BRD-K22949587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96453 Pars compacta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.349 JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8001 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.87756 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GPCRs class A rhodopsin like WikiPathways Pathways 2024 1.0 null Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.02185 Perturb_17229_KO_Tsc1_SRP096336 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.00289 LYSMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90691 HH CCLE Cell Line Gene CNV Profiles -1.0 -1.50365 BRD-K73337367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23506 POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC25A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03983 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07551 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14651 SW1783 CCLE Cell Line Gene Expression Profiles -1.0 -1.58951 hsa-miR-214 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K45860594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18249 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09584 ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5312 superficial stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10099 FAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45107 thalidomide-7288 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CEP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61051 CRCGN016_MCF10A.TP53.M_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65322 496100639_TCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.96762 BMI1 ChEA Transcription Factor Targets 1.0 null PIK3C2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1175 PLXNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7706 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20994 Prostate adenocarcinoma_PRAD_TCGA-EJ-5524-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042859 STK17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16897 CRCGN016_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43929 GSE126127_0_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.825696 Perturb_18112_KO_Eed_SRP132909 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 16.6256 Neostriatum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.673 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K89394474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08783 PPP1R14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61701 molecular transducer activity GO Molecular Function Annotations 2015 1.0 null Major island of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36679 HNF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92223 496100653_PCx_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.83719 CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.75169 CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8138 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82946 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.853356 hsa-miR-141 TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42635 BRD-K53720386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00619 CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.68796 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.871962 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30642 anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07159 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.896 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE42805,GSE42811_2_v_3_cocaine_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.15815 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.253 Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25337 Rectum adenocarcinoma_READ_TCGA-DY-A1DC-01A-31R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.992807 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.60513 hsa-miR-206 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3742-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3445-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CPC-N GDSC Cell Line Gene Expression Profiles 1.0 2.04891 BRD-K78197930 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16815 PHLPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8616 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null APOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24906 ventral tier of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57099 BRD-K98444789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50051 BRD-K74251295 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09275 2-iodomelatonin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57634 BRD-K22537050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01198 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null Panic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.167 Ebolavirus(ZEBOV)_6hr_Macrophage_22028943_GSE31747 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.59202 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.15759 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.324951 B4GALT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74072 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFSD13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10154 G protein-coupled receptor activity GO Molecular Function Annotations 2025 1.0 null hsa-miR-452 TargetScan Predicted Conserved microRNA Targets 1.0 0.248923 periventricular stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12327 pancreas GTEx Tissue Gene Expression Profiles 1.0 0.898898 UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02608 A2780 CCLE Cell Line Gene CNV Profiles -1.0 -1.71958 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -1.71059 BRD-K20962057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03151 Pallidum, dorsal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10734 NUMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33373 CRCGN016_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22028 EFNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2899 Dentate gyrus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11396 TAL1-20566737-PRIMARY FETAL LIVER ERYTHROID CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null calcium ion homeostasis GO Biological Process Annotations 2015 1.0 null outer SZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.932124 superficial stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10914 EBF1 ENCODE Transcription Factor Targets 1.0 null CTB-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.45522 granule cell layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44634 UPCISCC074 DepMap CRISPR Gene Dependency 1.0 2.4221 ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3343 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO678 CCLE Cell Line Gene CNV Profiles -1.0 -1.41136 CRCGN014_HEPG2_3H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0757 BRD-K57359365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54414 nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.4914 BRD-K80296876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55617 BRD-K53814023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18639 intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42602 mantle zone of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27348 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03219 PAK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00565 KS-IMM cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.722 PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4 Rummagene Transcription Factor Associations 2026 1.0 null PLPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12236 bed nucleus of the stria terminalis, mediocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31235 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17199106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30474 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CG-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13697 REST-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GCT COSMIC Cell Line Gene Mutation Profiles 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.51807 LASV_FML29 _4hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.16395 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.259 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5763 BRD-K89000000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24092 RCOR3-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.191 BRD-K73808079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16698 TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.54678 hilus of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17683 MYORG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74921 SISO DepMap CRISPR Gene Dependency 1.0 2.21599 Crus 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25633 Methionine CTD Gene-Chemical Interactions 1.0 null SW620 BioGPS Cell Line Gene Expression Profiles 1.0 0.863069 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.11408 SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null abnormality of coagulation GWASdb SNP-Phenotype Associations 1.0 0.203528 SW1417 CCLE Cell Line Gene CNV Profiles -1.0 -3.17976 USF2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K57356416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21252 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.851144 PRXL2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5807 EED ChEA Transcription Factor Targets 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null parabigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.68187 Field CA2, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12582 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null JMSU1 CCLE Cell Line Gene Expression Profiles -1.0 -1.46333 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03315 TOLLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19026 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06651 ARMCX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7084 ITGB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79068 Lateral septal nucleus, caudal (caudodorsal) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00181 SLC35A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08087 Olfactory tubercle Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45079 BRD-K01067435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63857 telencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.778155 Crus 2, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24931 BRD-K15907840 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21608 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.30766 YY1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-4506 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.95816 hsa-miR-922 TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 BRD-K14909006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59763 stria terminalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.388158 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K07431402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91276 inner CP in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10484 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EED-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z4-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSPG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3176 REST_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EM2 CCLE Cell Line Gene CNV Profiles 1.0 2.52707 dorsolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23529 BRD-K60743396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0086 KREMEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25335 IER5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0834 BRD-K41141507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0128 NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.914897 Idiopathic Pulmonary Fibrosis DisGeNET Gene-Disease Associations 1.0 null BRD-K41322154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00528 SCAPER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34021 ventral striatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76767 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934759 principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.859384 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03555 NRL_Deficiency_GDS1693_236_mouse_Photoreceptors cells of retinas at P2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null IBTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38927 hsa-miR-372 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null sphingosine-1-phosphate receptor activity GO Molecular Function Annotations 2025 1.0 null H3K9me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K50851442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49279 abnormal forebrain morphology MPO Gene-Phenotype Associations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MP-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041518 RL952 CCLE Cell Line Gene CNV Profiles -1.0 -1.75443 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04036 TOP2B-26459242-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-182 TargetScan Predicted Conserved microRNA Targets 1.0 0.248923 REST-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049432 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EMC-BAC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null striatal neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.387404 H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8413-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCIC4P DepMap CRISPR Gene Dependency 1.0 4.28234 SORBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87988 GSE65617_5_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null SHSYSY-RA BioGPS Cell Line Gene Expression Profiles -1.0 -0.974708 cellular homeostasis GO Biological Process Annotations 2015 1.0 null BRD-K58270905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25817 BRD-K25082699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00874 BRD-K19009697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36085 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.0688 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.47836 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5676-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Field CA1, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24693 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Submandibular lymph node TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.769 GNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36761 anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.967539 Cerebral granule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.356 BRD-K38493972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1719 496100334_PCx_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38516 EXTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34479 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP67-MEL GDSC Cell Line Gene Expression Profiles -1.0 -2.34993 ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5975 striatum (corpus striatum) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.12043 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11199 DPH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44535 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K77643021 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04546 brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043253 reinforcement GeneRIF Biological Term Annotations 1.0 null superficial stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33835 cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.268237 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Alzheimer Disease DisGeNET Gene-Disease Associations 1.0 null CRCGN010_HEPG2_24H:N19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.36232 amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15527 SFTPC_KO_GDS4876_476_mouse_Lung Type II cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5083 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61079130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17757 MYOG ENCODE Transcription Factor Targets 1.0 null SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.06411 DNAJC2-21179169-NT2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null regulation of cellular process GO Biological Process Annotations 2015 1.0 null BRD-K73792260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00362 H3K9me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Field CA3, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57099 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.53911 NCI-H1092 GDSC Cell Line Gene Expression Profiles 1.0 1.62816 neurogenetic GeneRIF Biological Term Annotations 1.0 null catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042649 mRNA_NANOG_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null SUZ12 ChEA Transcription Factor Targets 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPTSSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98175 REST_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K24343201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44236 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054319 DEGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16841 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null abnormal associative learning MPO Gene-Phenotype Associations 1.0 null BRD-K64748422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44849 SMAD3-21741376-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5979 substantia innominata/basal nucleus, transitional part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21856 CFPAC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.71772 P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE234289_4_v_2_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null KLF1 ChEA Transcription Factor Targets 1.0 null Amygdala TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.545 Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29103 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K50893227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50684 midbrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.253248 Cannabis dependence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 BRD-K84741596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00773 LEFTY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61054 ARHGEF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19592 19168792-TableS3 GeneSigDB Published Gene Signatures 1.0 null inorganic ion homeostasis GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22194 bed nucleus of the stria terminalis, laterocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11322 PMX2B MotifMap Predicted Transcription Factor Targets 1.0 null iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.22155 SMAD2/3-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null intermediate stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17785 NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835271 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_14689_KO_Ffar3_SRP057302 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.0904 Dopaminergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.176 Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.37475 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.962811 ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7047 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44617 EP300 ENCODE Transcription Factor Targets 1.0 null BRD-K75806288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21509 Sleep disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 Brain Lower Grade Glioma_LGG_TCGA-DU-5851-01A-13R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32235162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36327 superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8768 HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -0.924502 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.769855 SHMAC5 DepMap CRISPR Gene Dependency 1.0 2.19347 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06208 EDEM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94088 E2F6 ENCODE Transcription Factor Targets 1.0 null FEV JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9226 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32011 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.03805 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49694 subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7848 HCV_8week+IFN-a_None_GSE37715 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.63048 GSE210885_2_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.71849 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.888399 FADS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09092 FOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.3935 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.72424 BRD-K22748970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84783 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.82452 H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC4521181-oncsis201520x8.pdf-72-MYT1L_MYT1L Rummagene Transcription Factor Associations 2026 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06226 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.21267 MDAMB361 DepMap CRISPR Gene Dependency 1.0 6.07139 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K27me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AKT1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2699 centromedian nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13102 Medial geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4515 ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.624658 forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.71583 Perturb_16888_OE_Sca17_SRP248035 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.94874 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null BACH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.163 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.348 BRD-K76640951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35839 intermediate stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.9049 Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30255 BRD-K50045741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09243 BRD-K06450191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20835 core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67574 NCIH2004RT DepMap CRISPR Gene Dependency 1.0 2.99281 WDR5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63597 FBXW8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69278 Dorsal striatum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.465 16397240-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03315 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Toxic encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.251 SLC7A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33131 ZBTB20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88073 BRD-K86711517 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.15745 G-protein beta/gamma-subunit complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.547 PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00262 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.13348 CDT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63929 BRD-K24377650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33688 GSE231745_1_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SH4 CCLE Cell Line Gene CNV Profiles -1.0 -1.59673 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74395 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11084 abnormality of the coagulation cascade GWASdb SNP-Phenotype Associations 1.0 0.223343 BRD-K68683482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17051 IRAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51212 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.831968 BRD-K66823946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37924 biological_process GO Biological Process Annotations 2015 1.0 null BRD-K20415826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89163 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7731 BRD-K95551067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08148 BRD-K86964464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55425 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46206 BRD-K37000177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.176 Developmental and epileptic encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.902 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6836 hsa-miR-93 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028406 COLO704 CCLE Cell Line Gene Expression Profiles 1.0 1.56541 MYC ENCODE Transcription Factor Targets 1.0 null mammalian phenotype MPO Gene-Phenotype Associations 1.0 null striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 PRDM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51435 PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null Choline CTD Gene-Chemical Interactions 1.0 null Sebocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bioactive lipid receptor activity GO Molecular Function Annotations 2025 1.0 null NLGN4X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90528 GATA2 ENCODE Transcription Factor Targets 1.0 null ST8SIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43885 PANC1 CCLE Cell Line Gene CNV Profiles 1.0 1.74097 H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67329 PROSER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78656 RTL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49487 cell surface receptor signaling pathway GO Biological Process Annotations 2015 1.0 null Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 1.22696 HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7562 inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.859565 Nuclear outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.768 GABRE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02719 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01237 CRCGN014_HEPG2_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35424 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 SMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66886 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.4745 BRD-K77425312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93294 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pallidum (globus pallidus complex) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53427 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.19723 hsa-miR-4676-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.219115 HT29 BioGPS Cell Line Gene Expression Profiles 1.0 1.41237 ATP6AP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9347 RUNX1_KO_GDS1511_250_mouse_Embryos at E8.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MTMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79309 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K70992537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19873 Bed nuclei of the stria terminalis, anterior division, anteromedial area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13089 Medial habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10413 THAP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52218 H3K9me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.37813 BRD-K74116035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71558 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.997866 extrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.166643 BRD-K99119142 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17968 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRIMPOL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07527 OCT4-21477851-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6076 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K46739745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11728 hsa-miR-3673 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 Tauopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.742 CDH24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86187 striatum_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37164 FXR MotifMap Predicted Transcription Factor Targets 1.0 null Nucleus accumbens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.599 caudal putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.27317 BRD-K31936306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4524 BRD-K39526528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02384 BRD-K12271646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57582 PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null TMEM243 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69898 Sphingosine HMDB Metabolites of Enzymes 1.0 null BRD-K22839533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32019 ODF2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15979 medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03945 ChIP_SUZ12_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SOX6-21985497-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K84593579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.94204 RI1 DepMap CRISPR Gene Dependency 1.0 3.26403 BRD-K96778609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07941 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-520e TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 hsa-miR-4753-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 BRD-K57115335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46948 RAB3GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58578 BRD-K09078201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89376 septostriatal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10935 TYKNU CCLE Cell Line Gene CNV Profiles -1.0 -1.8226 BRD-K46641047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09387 MedullaOblongata BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.871777 HMEL CCLE Cell Line Gene Expression Profiles 1.0 1.53778 TTC38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46131 FUCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75458 GSE138001_0_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56895 Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDLIM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59669 CRCGN015_MCF10A.TP53.M_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1355 MOLT-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null EGR1 ChEA Transcription Factor Targets 1.0 null BRD-K28559679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17081 REST_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3 MotifMap Predicted Transcription Factor Targets 1.0 null EPLC272H DepMap CRISPR Gene Dependency 1.0 3.84458 RPRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28376 periventricular stratum of Dg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31258 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.887778 Hmgn1_KO_GDS5010_406_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H2BC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29002 CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -2.86112 ONECUT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8767 ANKS1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64123 ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145915_0_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66404 NCIH1734 CCLE Cell Line Gene CNV Profiles 1.0 1.66534 BATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8454 Necrosis CTD Gene-Disease Associations 1.0 1.14404 DICER1_KO_GDS4504_583_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K38434557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39161 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.987996 RAC3-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K81642886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02235 Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 46.4656 CRCGN017_MCF10A.WT.HP_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08595 FAM221A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7878 BRD-K46994278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13855 BRD-K21671578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51803 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH209 CCLE Cell Line Gene Expression Profiles 1.0 2.40513 H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FAM210B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97157 Substantia nigra TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.552 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.58062 BRD-K71005143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67795 EHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87654 Perturb_14982_KO_Setd1a_SRP330236 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.17357 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02508 BRD-K12148366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03615 determines GeneRIF Biological Term Annotations 1.0 null BRD-K50133846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17257 PPDPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03801 mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4518 H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.09535 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.11425 HCT8 CCLE Cell Line Gene Expression Profiles -1.0 -1.54834 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.18027 striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.88289 CRCGN015_HEPG2_48H:L24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56147 nervous system phenotype MPO Gene-Phenotype Associations 1.0 null HCC2935 DepMap CRISPR Gene Dependency 1.0 2.16592 BRD-K60068268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39041 Fundus of striatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31784 BRD-K37144511 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32949 BRD-K92460921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39891 GSE142684_2_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K66110520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04242 ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.0842 496100599_TCx_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08899 JMURTK2 DepMap CRISPR Gene Dependency 1.0 2.04873 basal ganglia disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.212945 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35251 CRCGN010_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.34865 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0302 Prefrontal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.449 BRD-K55946794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11849 PMC3435504-msb201237-s2.xls-Supp_Table_4b-REST_REST Rummagene Transcription Factor Associations 2026 1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 CRCGN017_MCF10A.WT.HP_24H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.71575 RI1 CCLE Cell Line Gene CNV Profiles -1.0 -1.58587 TAMALIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55921 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33076 GA10 CCLE Cell Line Gene Expression Profiles 1.0 1.4276 hsa-miR-545 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.67917 BRD-K74015591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49504 G protein-coupled receptor, rhodopsin-like InterPro Predicted Protein Domain Annotations 1.0 null Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 2.7076 Folic Acid CTD Gene-Chemical Interactions 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null quetiapine_mus musculus_gpl1261_gse45229 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Autoimmune disease of central nervous system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.479 CRCGN017_MCF10A.TP53.M_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25175 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.10025 Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPE1SS51 DepMap CRISPR Gene Dependency 1.0 4.37846 TAL1 ChEA Transcription Factor Targets 1.0 null CGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2514 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13057 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846796 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30226 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ventral striatum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.295 lateral portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77078 496100420_PCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02848 BRD-K10911459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0711 BRD-K68676343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1718 BRD-K99447506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89196 intermediate stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49439 superficial stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.388 AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.683098 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.902 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.087 Agnosia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.339 CRCGN016_MCF10A.TP53.M_24H:G21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.32016 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039564 HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43298 PAX5 ENCODE Transcription Factor Targets 1.0 null Bed nuclei of the stria terminalis, anterior division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17019 pallidal septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26519 L3MBTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7246 SUZ12-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K93337444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27295 FOXO3-23340844-DLD1-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Central medial thalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 extrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.183025 BRD-K45077605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0322 CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9805 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null gh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.546 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44337 FFAR4_KO_GDS4811_507_mouse_adipose GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K97576000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42324 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.769 RMI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28648 hsa-miR-3944-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68636 Macular degeneration_Fibroblast_GSE1719 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.87853 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853438 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.887166 KS-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.72768 BRD-K83670600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27636 NFXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30766 Pallidum, ventral region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06431 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070448 DYNLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56638 CDC42SE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61871 BRD-K42663371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96742 VMRCLCD CCLE Cell Line Gene CNV Profiles -1.0 -1.32746 Globus pallidus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.909 BRD-K95573463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.43487 Celiac Disease HuGE Navigator Gene-Phenotype Associations 1.0 null FOXH1-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null REST-18959480-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ChIP_K27me3_17603471_mouseNPC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TAF2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Pulmonary Edema CTD Gene-Disease Associations 1.0 1.15933 BRD-K43284834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77417 CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.452 ERF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42486 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.993562 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8283 CRCGN009_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45017 P31-FUJ COSMIC Cell Line Gene Mutation Profiles 1.0 null cerebellar granule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.654618 BRD-K65127260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08062 septopallidal core nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00897 Fatty Liver, Alcoholic CTD Gene-Disease Associations 1.0 1.07625 GSE144231_3_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33885 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_TCEA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K54495109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11062 TEAD4 ENCODE Transcription Factor Targets 1.0 null preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3206 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Movement disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.227 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K72646819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77645 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Communication disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.356 hippocampus (hippocampal formation)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21443 BRD-K87053028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20813 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A770-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68323967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13007 BRD-K41433616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.51202 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.262 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.842685 BRD-K13472433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18809 Cerebellar granule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.353 mantle zone of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84903 GATA3 ENCODE Transcription Factor Targets 1.0 null GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null putamen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.34218 molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16992 BRD-K05378136 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4055 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.960585 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37254228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30504 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 SAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99589 BRD-K15708264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10305 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.952754 hsa-miR-578 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 PLOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68781 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-302c TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 BRD-K99377541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07323 PEPD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86401 MYSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15671 KP-N-YS COSMIC Cell Line Gene Mutation Profiles 1.0 null LASV_FML29_8hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.82068 Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 60.1479 SUZ12-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01639528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5661 EIF3M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48352 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61209548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13431 intermediate stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22405 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.826 BRD-K63626200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33489 striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10815 pontine nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22408 BRD-K91057865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19532 CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.55777 ChIP_K27me3_17603471_mouseMEF ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null cation homeostasis GO Biological Process Annotations 2015 1.0 null ZNF322 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42377 Striatum ventral region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69123 PKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83714 retrohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06667 superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1426 SLC36A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46821 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0856 WM-115 GDSC Cell Line Gene Expression Profiles -1.0 -1.47971 GPCR, rhodopsin-like, 7TM InterPro Predicted Protein Domain Annotations 1.0 null superficial stratum of CA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44466 hsa-miR-20b TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 striatal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67266 ChIP_NANOG_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23061 NRSE MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.59704 MDA-MB-468 GDSC Cell Line Gene Expression Profiles -1.0 -1.75936 H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.23424 BCL11B_KO_GSE9330_4_mouse_brain (striatum) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hsa-miR-96 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54733 TMUB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76253 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6303 Midbrain central gray TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.782 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.996254 19168792-TableS2 GeneSigDB Published Gene Signatures 1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K68608492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47583 PMC7770114__F7 PFOCR Pathway Figure Associations 2024 1.0 null PLEKHO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92628 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05479 BRD-K55809413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25205 GSE149035_2_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47183 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08492 Rectum adenocarcinoma_READ_TCGA-EF-5831-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100630_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06721 SKNAS CCLE Cell Line Gene CNV Profiles -1.0 -1.53827 MRPS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59963 lateral septal nucleus, intermediate part, periventricular Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64062 PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST Rummagene Transcription Factor Associations 2026 1.0 null basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894275 TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960449 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null medial geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47618 CRCGN017_MCF10A.TP53.M_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09998 hsa-miR-761 TargetScan Predicted Conserved microRNA Targets 1.0 0.361556 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Field CA3, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26106 interstitial nucleus of the posterior limb of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02357 E2A MotifMap Predicted Transcription Factor Targets 1.0 null REST_Panc1_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K14364923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.49961 TEAD4_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SACS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94904 CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.4882 CDC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39605 POLE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8369 CCRF-CEM COSMIC Cell Line Gene Mutation Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K45762887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44425 cellular_component GO Cellular Component Annotations 2015 1.0 null U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.89634 intermediate stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02928 G protein-coupled receptor 3/6/12 orphan InterPro Predicted Protein Domain Annotations 1.0 null BRD-K30761927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94184 NU-DUL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33185 BRD-K56868780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75589 PMC3435504-msb201237-s2.xls-Supp_Table_4c-REST_REST Rummagene Transcription Factor Associations 2026 1.0 null ascidian TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.569222 BMI1-23680149-NPCS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF713 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39699 hsa-miR-3619-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.336728 hsa-miR-302a TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 ICC12 DepMap CRISPR Gene Dependency 1.0 4.67375 FAM110C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00903 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19606 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.7105 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63559 CALR_KO_GDS3680_149_mouse_embryonic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NUDT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58209 ATF MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-FX-A3RE-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98542 H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TSSK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03578 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25859 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67839 nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15175 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7719 brain GTEx Tissue Gene Expression Profiles 1.0 1.5425 Autism spectrum disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.408 BRD-K24848743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86223 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7177-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null heterotrimeric g-protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.268237 BT20 CCLE Cell Line Gene CNV Profiles 1.0 2.84856 SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HBEGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55319 smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068811 BRD-K05070188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05201 MESSA CCLE Cell Line Gene CNV Profiles -1.0 -1.36644 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 psa1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.317 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.936058 TCF4-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null computational GeneRIF Biological Term Annotations 1.0 null Dravet syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.99 D-566MG GDSC Cell Line Gene Expression Profiles -1.0 -1.77294 BRD-K26395018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6638 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45486 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81185 GPX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5823 ventral subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29235 BRD-K14763154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21077 CRCGN015_HEPG2_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.74453 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.91343 Hedgehog signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 cellular process GO Biological Process Annotations 2015 1.0 null hsa-miR-520b TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 FOXL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74386 integral component of membrane GO Cellular Component Annotations 2015 1.0 null Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 SOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31087 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0665 BRD-K94862255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21411 ATF2 ENCODE Transcription Factor Targets 1.0 null Olfactory tubercle, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41972 Twist2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8894 ChIP_REST_18959480 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ELOF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03639 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00308 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H838 GDSC Cell Line Gene Expression Profiles -1.0 -1.53252 MTF2 ChEA Transcription Factor Targets 1.0 null H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9239 abnormal basal ganglion morphology MPO Gene-Phenotype Associations 1.0 null REST_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26586 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A901-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G415 DepMap CRISPR Gene Dependency 1.0 3.12693 P53-22127205-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K43449580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50195 BRD-K91620436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.153 GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14083 LINGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02378 GATA2_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2-21186366-BM-HSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SAP30L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91505 LTBR_INHIBITION - 27 Day_GDS2005_731_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null substantia innominata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.908902 HTK CCLE Cell Line Gene Expression Profiles -1.0 -1.6762 BRD-K95822658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02924 putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.59105 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.851144 496100609_TCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.34071 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0174 BRD-K26767874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2772 inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14576 GSE205163,GSE205164_5_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null IC-86621-7548 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K52354895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.4424 BRD-K22039769 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25795 Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14439 Poisoning CTD Gene-Disease Associations 1.0 1.33672 Field CA2, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48554 hsa-miR-646 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Central medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07763 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null CSNK1G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51519 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52176 superficial stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47438 Caudate putamen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.461 GADD45B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17647 Striatum dorsal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.02626 cellular divalent inorganic cation homeostasis GO Biological Process Annotations 2015 1.0 null Striatal neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.948 TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6258 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00662 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56954 Striatopallidal loop cell_Striatum_Mouse CellMarker Gene-Cell Type Associations 1.0 null CNIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9102 TPST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56041 central subpallium (classic basal ganglia) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78532 single-organism cellular process GO Biological Process Annotations 2015 1.0 null GSE144231_4_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.128913 CTSC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61897 BRD-K88960810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35567 RARA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88083 SCC15 CCLE Cell Line Gene Expression Profiles -1.0 -1.84472 NCI-H64 GDSC Cell Line Gene Expression Profiles 1.0 1.44418 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02534 KDM5A ENCODE Transcription Factor Targets 1.0 null endothelial GeneRIF Biological Term Annotations 1.0 null BRD-K27719710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63679 LSM14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63862 BRD-K11893906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0874 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.08622 Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23899 Diabetes Mellitus, Type 1 HuGE Navigator Gene-Phenotype Associations 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46645 ATP6V1G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.924 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23302 Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF607 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63114 MYC-19915707-AK7-human ChEA Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sodium-phenylacetate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50906 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null PMEPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66341 ARF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72964 EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1436 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null STARD3NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96181 Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plicamycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69984 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2422 BRD-K63030320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40655 18223198-TableS3 GeneSigDB Published Gene Signatures 1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE142684_4_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null Corpus striatum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.221 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.47827 ventral pallidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25337 VPS26A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44943 BRD-K04407772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72523 Infralimbic cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.621 CRCGN015_MCF10A_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14766 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.64361 Perturb_16840_KO_Bcl11b_SRP340294 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -19.699 THBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17429 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.56534 SMAD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34207 amygdala TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.152638 Subthalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.553 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8095 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48712 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36338 Lennox-Gastaut syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.038 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 d2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 RXRA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.324951 CRCGN013_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26679 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24357 BRD-K40418847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.189 hsa-miR-20a TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 BRD-K15940471 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20142 REST_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37237818 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45098 plexiform layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05611 PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SCCOHT1 DepMap CRISPR Gene Dependency 1.0 3.63632 BCL2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58168 BRD-K47471281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77402 C18orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51912 Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null WERIRB1 DepMap CRISPR Gene Dependency 1.0 3.08586 UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null internal globus pallidus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11757 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050913 EED-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null solasodine-4305 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 KIF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4568 PNMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95078 CBX3 ENCODE Transcription Factor Targets 1.0 null IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.880756 PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-332-ZNF571-AS1_ZNF571 Rummagene Transcription Factor Associations 2026 1.0 null ENOSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64729 HNF1A_OE_GDS1499_252_human_HEK293 embryonic kidney cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.78538 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0391 REST_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77987907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21598 BRD-K39979171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24106 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.50739 CORL311 CCLE Cell Line Gene Expression Profiles 1.0 1.39565 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72726 hsa-miR-4643 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2499 Lateral septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1274 shikonin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97556 COL6A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87102 cerebral cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.789796 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1198 GSE108675_2_v_1_slc1a4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GOLGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02584 SLC25A34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84461 REST_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MSANTD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2388 CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05451 CRCGN016_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8053 imatinib_homo sapiens_gpl201_gds838 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HG3 DepMap CRISPR Gene Dependency 1.0 2.91183 CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.775 CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.46619 H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K34501072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73669 GABRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52313 HOUAI DepMap CRISPR Gene Dependency 1.0 4.18099 gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042319 H3K9me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NP5 DepMap CRISPR Gene Dependency 1.0 2.52066 GSE65617_2_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRPEL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96692 central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044099 Field CA2, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15451 BRD-K76202128 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5026 REST ENCODE Transcription Factor Targets 1.0 null DMS53 CCLE Cell Line Gene Expression Profiles 1.0 1.59259 mantle zone of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16802 r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17515 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040456 TAL1-21186366-BM-HSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HEC6 CCLE Cell Line Gene CNV Profiles 1.0 1.34163 BRD-K49932469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01094 CAOV4 CCLE Cell Line Gene CNV Profiles -1.0 -1.44343 PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22831 septostriatal transition area (accumbens) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85079 BRD-K36055854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20352 BRD-K52812196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49938 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GU-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRC26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03151 Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.866 Lung squamous cell carcinoma_LUSC_TCGA-85-8580-01A-31R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.851144 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K07734771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43816 CRCGN017_MCF10A.TP53.M_24H:D22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1029 iobenguane-6002 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sphingosine GeneRIF Biological Term Annotations 1.0 null Islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43705 Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CAND2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5071 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.507849 BRD-K04714488 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18805 PMC3435504-msb201237-s2.xls-Supp_Table_4a-REST_REST Rummagene Transcription Factor Associations 2026 1.0 null Olfactory tubercle, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40502 intermediate part of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09103 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25316 H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_2_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K29571884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41249 ion homeostasis GO Biological Process Annotations 2015 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null g-protein coupled receptor activity GO Molecular Function Annotations 2015 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NUAK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24952 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0174 NUDT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32856 intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04662 H3K27me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3408 Gilles de la Tourette syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 sphingosine-1-phosphate receptor activity GO Molecular Function Annotations 2023 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877332 Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parasubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19511 mecamylamine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82584 ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.6246 BRD-K28923989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43205 ZNF292 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28047 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE81803,GSE81912_0_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null vascular smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.523588 CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.93115 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18618 CLINDAMYCIN-PO4 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57367 CRCGN010_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04124 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.847868 BRD-K27026825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54375 BRD-K60782883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82926 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 1.31948 CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.44363 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -0.985461 Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25457 hsa-miR-106a TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 BATF::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6204 disease GWASdb SNP-Disease Associations 1.0 0.024216 PANC-03-27 GDSC Cell Line Gene Expression Profiles -1.0 -2.061 BRD-K27838482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86882 BRD-K46913557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12646 BRD-K08000110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.47522 H3K9me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null STYX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78211 FOXO3-23340844-DLD1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K19040732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05357 frontal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.259929 CRCGN016_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14132 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.913599 CRCGN016_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23214 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K46308702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38982 HCCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11647 NCI-H345 GDSC Cell Line Gene Expression Profiles 1.0 3.37624 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 CORL51 CCLE Cell Line Gene Expression Profiles 1.0 2.03026 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K96133500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23809 496100425_TCx_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.20022 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2471