association	dataset	threshold value	standardized value
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	1.11462
Rutin (trihydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0409319
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2979-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58273
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
HUT102	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7242
GTEX-QXCU-0326-SM-2TC63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890542
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2649
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2397
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.773
Aripiprazole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2451
Ivermectin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197131
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2588
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19608
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243431
hsa-miR-548ae	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7443
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-80-5608-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE180_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	4.15272
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14347
hsa-miR-4328	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
metampicillin-2123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53404
Perturb_8856_OE_ERG3_SRP034736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.56579
PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671	Rummagene Transcription Factor Associations 2026	1.0	null
U251	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.945781
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RPMI-2650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K20495487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57943
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.880805
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86561
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pyrvinium-6339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27179
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11743
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-REY6-1726-SM-48FDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1563
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99814
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SEC63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6132
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TNK1	Kinase Library Tyrosine Kinome Atlas	1.0	99.02
SARS-CoV_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.01327
TCF7	ChEA Transcription Factor Targets	1.0	null
BRD-K53617314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1868
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50737
GSE60691_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RN64-0726-SM-48FCV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873716
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05682
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31853
UBTF	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28762
trimethoprim-7377	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN010_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08367
UBE2G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88604
induction	GeneRIF Biological Term Annotations	1.0	null
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.992
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10824
dextromethorphan-6300	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.69821
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49996
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.05757
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28628
CRCGN016_MCF10A.WT.HP_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6067
metolazone-5392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EWS-FLI1-20517297-SK-N-MC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84272
CHML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05979
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1302
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HLE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95182
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AT7519_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154846
SKMEL28	CCLE Cell Line Gene Expression Profiles	1.0	2.04372
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYOD1	ENCODE Transcription Factor Targets	1.0	null
ornidazole-5064	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20623
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052417
KDM3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480154
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
NB17	DepMap CRISPR Gene Dependency	1.0	4.8635
LDB1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37291
suramin sodium-7529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.57329
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.24224
BRD-K98272474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60681
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.850562
breast cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062752
A3KAW	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67548
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07572
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315671
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31642
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cyproheptadine-5340	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
probenecid-4771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9858
Vortioxetine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0400804
TPGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1585
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49073
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-CLOSEST_GENE_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21313
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22868
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083509
GSE131377_4_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066786
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Laryngeal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
HT1080	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.03329
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240152
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
aconitine-6797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16889
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16756
hsa-miR-944	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
HUH-6-CLONE5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SYK_knockdown_279_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.57721
E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055073
ATP1A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539076
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886092
Fetal Lung	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.08537
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
KDM2B-26808549-CHIP-SEQ-DND41-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.705
FOXA2	ChEA Transcription Factor Targets	1.0	null
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359673
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219928
GSE203308_7_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02546
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Apoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.07
GSE120612_6_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bromopride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24976
Perturb_16739_KO_Gcn5_SRP271119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7699
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78439758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36669
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
isradipine-5447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29128
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.6524
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19685
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986529
PFKL_OE_GDS4410_202_human_biceps	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.931429
erg_19359602_huvec_lof_human_gpl570_gds3557	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.507921
GSE216538_1_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fumaric acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0380744
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111102,GSE111105_8_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML3-OVERLAP_GENES_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4475	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04236
CACNA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0079592
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212761
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96894
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211936
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KOPN8	CCLE Cell Line Gene Expression Profiles	1.0	1.97252
RAD21	ENCODE Transcription Factor Targets	1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44468
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.97
SP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02986
A431	DepMap CRISPR Gene Dependency	1.0	4.26903
Guanethidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.53
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20671
moxisylyte-7015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16914
ES-WA7 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.47871
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.50689
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chromosome 15q11.2 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC5997167__F5	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-135a	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
Lung squamous cell carcinoma_LUSC_TCGA-34-5231-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU719	DepMap CRISPR Gene Dependency	1.0	2.75395
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04189
FGFR2	Kinase Library Tyrosine Kinome Atlas	1.0	96.1
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4422	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
foxa1_23539448_lncap_lof_human_gpl10558_gse37314	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.183079
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
JSRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00717528
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.067275
H1_Derived_Mesenchymal_Stem_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.903855
Tucatinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134801
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5250-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07135
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4884
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.893959
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46549154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32341
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.29533
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33701
BRD-K99953989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.29652
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.919936
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STK368746	DeepCoverMOA Drug Mechanisms of Action	1.0	0.47
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62674
GTEX-WH7G-1326-SM-4LVMS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85899
UBTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48919
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.200289
hsa-miR-4659b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
(-)-atenolol-6725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13559
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52788
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214605
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Gene_Name_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QCQG-1626-SM-48U26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22447
meprylcaine-5723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054251
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4666-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25897
BRD-K65314728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05806
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64884
HS936T	DepMap CRISPR Gene Dependency	1.0	4.76506
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03540982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05426
Perturb_1603_KO_Tlr4_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.55922
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
placenta	HPA Tissue Protein Expression Profiles	1.0	2.38337
BLK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00802662
GSE165307_2_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4313	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03987
TMEM54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44559
pergolide-7271	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-1526-SM-4AT5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41531
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.956373
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835929
PMC9883165-41375_2022_1744_MOESM4_ESM.xlsx-CEBP_gene_module-Unnamed_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.877639
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02847
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE89569_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618067
Perturb_5501_Mut|KO_Hras_SRP026484	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.72578
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15454
STAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546038
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.2658
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151494_10_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CYFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57434
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
SARS-dORF6_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.58233
DCA_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96316
ISHIKAWA(HERAKLIO)02ER-	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE248858_6_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Esmolol (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0228445
Perturb_18013_KO_miR18a_SRP050491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.36459
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.12263
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935958
hsa-miR-4287	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.559021
Budesonide_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0297451
GTEX-WFON-1926-SM-3LK7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14275
PFKL_OE_GDS4410_75_human_Biceps muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903881
GSE215086_0_v_2_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.0246
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.12426
hsa-miR-3652	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
APP	Pathway Commons Protein-Protein Interactions	1.0	null
sulfamethoxazole-7366	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04507
BRD-K37269981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73708
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265442
BRD-K20724649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0117
TK10	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.85811
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13005_KD_SPI1_SRP090090	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
strophanthidin-2525	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5303-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.8761
PDGFRB	Kinase Library Tyrosine Kinome Atlas	1.0	98.49
mesalazine-124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALLSIL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58449
LY 364947	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
hsa-miR-4766-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
caco2	HPA Cell Line Gene Expression Profiles	-1.0	-0.850268
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.060156
Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47947160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05957
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30284
docosahexaenoic acid ethyl ester-664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cdkn1b_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl6246_gse27672	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.999728
Lung squamous cell carcinoma_LUSC_TCGA-98-A538-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00817528
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
clinicopathological	GeneRIF Biological Term Annotations	1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SYT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617857
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAD2L1BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75471
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52489
lycorine-2195	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCEA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70216
CCND2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00825788
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21394
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K37282009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26823
upon	GeneRIF Biological Term Annotations	1.0	null
cefuroxime-6088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.971859
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46043
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.03762
PMC10350077-media-8.xlsx-Controls_LPS_enriched_Down_KEGG-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.13255
MDAMB453	CCLE Cell Line Gene CNV Profiles	1.0	2.56344
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
CHCHD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457443
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11473
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233371
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80396088_Gliquidone_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8992
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19221
diclofenac-7215	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.183248
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bone inflammation disease	GWASdb SNP-Disease Associations	1.0	0.250867
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841638
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56261053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60935
GSE114992,GSE114993_0_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319529
BRD-K28429328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3076
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FFAR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441881
hsa-miR-144	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05982
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.8522
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38408
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01587
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91186
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
flumethasone-pivalate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25724
Perturb_6137_KO_Yap1/Wwtr1_SRP314027	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.86401
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944951
Sildenafil	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.23
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54884
clidinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37428
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
tiratricol-2096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82194980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3478
BRD-K57650037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38658
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8508-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11572
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13656
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.907015
Perturb_9550_KO_Becn1_SRP255651	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.72421
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10372
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RGS10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00720621
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GTPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55508
BRD-K70936779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53281
RING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05265
BRD-K00446585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26079
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14988
Perturb_1177_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-QV31-1626-SM-2S1QC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15547
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
independent	GeneRIF Biological Term Annotations	1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0266
BRD-K01787291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.159
BRD-K21879622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01095
BRD-K58232861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70344
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8741
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.574217
UGP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52835
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01165
PDS5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00434148
SMAD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0130663
SMYD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491925
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SCAMP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469024
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73433
M14	BioGPS Cell Line Gene Expression Profiles	1.0	2.05609
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14591
CDK8_knockdown_63_GSE19199	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.68872
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29489
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862544
GSE146074_10_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66481
BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7927818-AAC.01755-20-s0002.xlsx-Supplemental_Table_1-Supplemental_Table_1_List_of_significantly_altered_genes_in_MDMs_differentiated_in_the_presence_of_PrEP_FTC_v_No_Drug_TDF_v_No_Drug_FTC_v_TDF_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K70145120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42771
Perturb_3471_Mut_Atxn1_SRP148491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.09682
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211557
CLASRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04447
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29557
BRD-K62892366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26581
BRD-K42960858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68938
TD-69-UA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540342
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66746
GTEX-XV7Q-2126-SM-4BRVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08955
CXADR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604117
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70532227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26701
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nevirapine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219017
Perturb_1078_OE_ZBED2_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
biological_process	GO Biological Process Annotations 2015	1.0	null
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54879
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3717
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16957
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845374
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220831
PMC12229841-Table2.xlsx-BL_NS_vs_BL_LPS-Negative_logFC_up_at_non-stimulated_Postive_logFC_up_after_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130401_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.870365
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.868073
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83938
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986565
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	1.35254
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44038
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO Biological Process Annotations 2023	1.0	null
PPP2R3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570968
GSE114992,GSE114993_9_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130081,GSE130082_5_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10309_KO_Nos3_SRP286435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.38949
PRX-08066	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
TRIM69	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692843
SLC4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12887
P2RY12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660952
Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41821
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04387
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90894
ECC2	DepMap CRISPR Gene Dependency	1.0	2.24222
NOL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18554
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1152
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31034
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315031
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.968669
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.953319
Gallic acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0303699
Finasteride_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0227229
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
trichostatin A-1561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-548ac	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
MC-3T3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28829
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	9.0061
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53917
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18504
BRD-K78837609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34445
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23416
hsa-miR-4768-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
mitochondria	GeneRIF Biological Term Annotations	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98548675_Parthenolide_NOMO1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.39221
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05504
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10017
PF382	CCLE Cell Line Gene Expression Profiles	1.0	2.11593
BAY1125976_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0302473
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24055
16288205-GeneTable2	GeneSigDB Published Gene Signatures	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.68705
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alveolar macrophage cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56456
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
gallbladder	HPA Tissue Protein Expression Profiles	1.0	2.38337
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	1.27435
Perturb_4491_KO_Tcf4_SRP072458	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32513
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TV-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.9622
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE1551	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.91885
GTEX-XYKS-2126-SM-4E3IB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989846
Belumosudil_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0278638
GTEX-QCQG-0526-SM-48U2A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945101
MGAT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69178
TGIF2LY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13232
GATA2-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18321
CCDC86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00431633
CRCGN016_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12859
CRCGN008_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02415
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.976031
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33391
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.890798
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04549
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18867
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DND41	CCLE Cell Line Gene Expression Profiles	1.0	2.39069
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23246
BID	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614597
etoposide-1626	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
MAP2K1_druginhibition_172_GSE39984	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.98601
miR-124_OE_GDS2657_770_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TUBB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00367003
GTEX-PW2O-0226-SM-48TC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39825
u266	HPA Cell Line Gene Expression Profiles	-1.0	-0.830126
cell death	GO Biological Process Annotations 2015	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K93900188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26962
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
PCNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27993
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33493
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21547
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2352
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hcc	GeneRIF Biological Term Annotations	1.0	null
Ponatinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0292689
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72059
BRD-K83994491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17027
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065941
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02023
BRD-K87516578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47174
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.937143
GTEX-SE5C-1526-SM-4BRWU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983346
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.977184
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30429
P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.983876
Prestwick-675-7381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC3371315-NIHMS350140-supplement-13.xls-MCF7-T47D-SK-453_Up_Common_xls-Supplementary_Table_6_Luminal_Signature_Genes_increased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.45165
BRD-K73337367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43784
CAV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570792
Lung adenocarcinoma_LUAD_TCGA-99-8032-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PF-3845_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177484
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84097
Lung adenocarcinoma_LUAD_TCGA-44-8119-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052133
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54134
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMP13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0039701
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4C9-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857679
CEBPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12245
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6531
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-2526-SM-2TC6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02617
LSM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13037
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662055
BRD-K71544970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16871
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223906
H3K36me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193624_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4390-01A-02R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859453
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
Perturb_1806_KO_Trif_SRP377807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.94788
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
ERBB3_knockdown_65_GSE19921	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.64372
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64147
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195582_2_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Berberine (chloride hydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245378
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35577
dorzolamide-5785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC22A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060429
Perturb_5521_KD_Apoa4_SRP393880	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.17643
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.860584
BRD-K71647210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31531
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S341-0626-SM-4AD5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928728
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946534
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33598
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97773
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.069
mebendazole-7370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040925
ERG_01_17	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58527
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.087
breast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058801
BRD-K75576005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82701
Perturb_14267_OE_Mir144_SRP305305	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.3203
TCF3	ENCODE Transcription Factor Targets	1.0	null
TRPM7_overexpression_305_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.37017
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_30_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PW2O-0008-SM-48TEB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910464
TNFRSF14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640831
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
arthritis	GWASdb SNP-Phenotype Associations	1.0	0.214895
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04385
GSE86507,GSE86509_3_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0486
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178907_5_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25291
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2151
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.396037
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12036_KD_Prmt6_SRP131294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.06554
Roflumilast	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A70Z-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1969_KO_Grn_SRP314934	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65328
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hydroxyurea_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00787019
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862424
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.999613
BRD-K91022335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01133
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AH-1226-SM-48TZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40905
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92118
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28272
ABCA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631964
DLD1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.78862
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21035
BCB000039-7536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51256
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71B-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7159-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2881
GTEx AdiposeTissue 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-15.5623
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42835
BRD-K16852474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04031
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.73022
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857121
hsa-miR-3607-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
BRD-K43922968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0076
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2929
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KNG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537157
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81644801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48276
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94402
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67T-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.938376
INSR	Kinase Library Tyrosine Kinome Atlas	1.0	99.37
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226983_1_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ospemifene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Lomustine_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167389
NR-8383 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39874
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79984
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31571
BRD-K34720817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48257
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885211
CRCGN014_HEPG2_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02032
BRD-K68312794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08375
BRD-K31187110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3543
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
C99	DepMap CRISPR Gene Dependency	1.0	2.12107
DTP3_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0193944
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6571-01A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Corm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.988
SW900	CCLE Cell Line Gene CNV Profiles	1.0	1.34803
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879593
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MOTN1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53685
GSE100316_3_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7463-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OTS514_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132388
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056033
BRD-K37865504_LY-2183240_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97895
Perturb_1834_KO_Ogt_SRP250299	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.9393
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12848082-41598_2025_33574_MOESM3_ESM.xlsx-MR-PRESSO_eQTL-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00531
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10552
NCI-H720	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OCIM2	DepMap CRISPR Gene Dependency	1.0	4.69749
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	2.45338
plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.07368
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OUMS-23	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_17377_KD_E2f1/Myc/Pparg/Stat6_SRP190223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21675
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tranexamic acid-2085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5683
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06933
ACVRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567529
11-deoxy-16,16-dimethylprostaglandin E2-7538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4430	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K89423851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14588
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FCGR1BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488128
LMO2	ChEA Transcription Factor Targets	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-BCL9-STAT3_targets_DEG_Control-GeneName_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.073547
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14671528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16777
phenanthridinone-1115	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.592501
molt4	HPA Cell Line Gene Expression Profiles	1.0	0.8569
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01673
Lidocaine (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266529
epiandrosterone-3306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4UY-0826-SM-4AD4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65004
BRD-K49371609_528116.cdx_PC3_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ejaculatory duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48354
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.05126
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-32-5p	MiRTarBase microRNA Targets	1.0	null
PDE4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00751362
p53independent	GeneRIF Biological Term Annotations	1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929125
delavirdine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20095
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63892
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
APTO-253_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00838454
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83733
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41652
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58412
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-OVERLAP_GENES_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
Dichlorphenamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9693
resveratrol-662	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985103
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
GSE149075_8_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
following	GeneRIF Biological Term Annotations	1.0	null
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98324
CHRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493832
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23374
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05302
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48050202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44189
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20775
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36176
isoxicam-1698	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.5815
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3698_KD_FTO_SRP226373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.04955
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.965963
Perturb_12958_KO_KDSR_SRP308393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.5707
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.18664
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.488
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96186
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27031
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92457070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00861
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0099
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871626
BRD-K91241684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12843
ARL6IP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425427
embryonic carcinoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
paracetamol-6284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23166
Depression_Cerebral cortex_GSE12654	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.70801
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8244
CRCGN017_MCF10A.WT.HP_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.336
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Squamous Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
nicotinic acid-5301	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18415
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15435
tolfenamic acid-5454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.48736
BRD-K61220066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26711
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24443
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863843
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
brompheniramine-4013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1447
VN(H5N1)_12hour_None_GSE37245	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75785
BRD-K48556518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55751
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.695718
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25111
GTEX-WHWD-1826-SM-3LK6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45261
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FGR	Kinase Library Tyrosine Kinome Atlas	1.0	98.47
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-0926-SM-3P5ZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33445
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBK1_knockdown_53_GSE17643	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.55974
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
GSE146074_1_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cephalothin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50047
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D0-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.126032
pilocarpine-6741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ESRRG_Deficiency_GDS2811_638_mouse_Fetal heart - Homozygous null mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.7114
PMC9046280-41467_2022_29963_MOESM5_ESM.xlsx-ASCL1_motif-Gene_Name_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
pirlindole-5497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GW 501516	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Xeroderma pigmentosum group A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
ATP1A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055885
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RNOR-0426-SM-2TF4U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925695
BRD-K96652989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66778
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.28707
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21108
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
16288205-GeneTable3	GeneSigDB Published Gene Signatures	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35605
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebrooculofacioskeletal syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
BRD-K23327891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61572
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-361	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Schindler disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7973-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04777
estradiol_homo sapiens_gpl1225_gse1486	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.963106
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02675
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37716
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.49426
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052507
negative regulation of cytoplasmic pattern recognition receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
Perturb_6377_KD_lncRNAHUMT_SRP326145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183251_1_v_5_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
DYRK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487566
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71401
KIR2DS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058046
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H660 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.532
ADGRE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00749695
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34213
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347325
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71739
NCIH1693	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89849
Perturb_11151_OE_Aeg1/Myc_SRP048459	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.97977
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11832
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dimethyl fumarate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0379002
GSE147669_2_v_1_tram2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74626943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6417
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38668
Perturb_13915_KD_SLC45A4_SRP173763	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.10008
hsa-miR-665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K18629365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50124
Perturb_1206_KO_Sp3_SRP302435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.79755
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15273
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JW-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6085
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IRF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704218
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51485
GTEX-XQ8I-2126-SM-4BOOM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18916
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.759
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60043
HT-1197	COSMIC Cell Line Gene Mutation Profiles	1.0	null
chlorpromazine-1642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896817
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.46024
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87099
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
20081105-ST-1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970253
PRSS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486267
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-6025-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22341
NVP-BHG712_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266048
Perturb_14268_OE_Mir451a_SRP305305	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.0402
tolazamide-2842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Betamethasone dipropionate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189539
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.17126
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM5_ESM.xlsx-Super_enhancers_in_T-ALL3-OVERLAP_GENES_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
santonin-4531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_Targetome-Genes_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12843
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843948
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAPK8IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49533
RCC-FG2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4583
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23777
TALL1	CCLE Cell Line Gene Expression Profiles	1.0	1.95777
Anemia	CTD Gene-Disease Associations	1.0	1.14954
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01709
hsa-miR-501-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
BRD-K34264024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34928
PAWR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050327
CRCGN015_MCF10A.TP53.M_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00035
GTEX-WHSB-1626-SM-3LK6J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886677
Rifaximin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
GSE96991,GSE97117_3_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWOO-2426-SM-2S1OV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11497
betamethasone-valerate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13058
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-576-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
estrone-6647	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH2073	CCLE Cell Line Gene CNV Profiles	1.0	1.55621
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PBX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81559
Arsenic	CTD Gene-Chemical Interactions	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03171
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19662
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21968
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2212
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02788568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54304
Perturb_16580_KO_Ep300_SRP174041	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.53411
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.915073
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
death	GO Biological Process Annotations 2015	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044046
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE247862,GSE247863_0_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hep-g2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.283545
suxibuzone-7163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.03762
GTEX-S33H-1826-SM-4AD65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32879
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847101
SG231	DepMap CRISPR Gene Dependency	1.0	2.71457
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1444
AdrenalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.71202
NCO2	CCLE Cell Line Gene Expression Profiles	1.0	1.50539
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWCY-0426-SM-48TCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82563
BRD-A89947015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07164
GSE189834,GSE189836_1_v_0_brd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584759
PMC10861538-41467_2024_45669_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_DEGs_upon_KD_of_EVT_TFs_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7161-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072434
ZNF646	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741023
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Migalastat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957018
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
HCC1937	COSMIC Cell Line Gene Mutation Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76K-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WX-01A-22R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18113
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CACHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516867
Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64883
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.99837
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FD-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2592
BRD-K85775326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95191
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290923
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23521
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	1.83818
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05144
hsa-miR-3176	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
HCMV_24Hour-anti_EGFR_treatment_20173022_GSE17948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.09054
Prucalopride	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.59265
GSE88819_6_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92520489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66552
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03736784_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.24206
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
flunixin-3411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.220515
ADAM17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640486
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.13315
GSE169571_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LGR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564875
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80424
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aiolos_NULL MUTATION_GDS3473_572_mouse_Bone marrow pre-BII cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.59613
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37906
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
torasemide-5476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OIZH-3026-SM-3NB1G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02858
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02025
BRD-K47984776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7752
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48129
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23035
MFE296	DepMap CRISPR Gene Dependency	1.0	5.52389
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4789-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
MYEOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662705
hsa-miR-548d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4845-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u138mg	HPA Cell Line Gene Expression Profiles	-1.0	-0.9831
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.853622
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.56979
AKR1C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00731922
GTEX-T2IS-0126-SM-4DM6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0149
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318592
BRD-K21356734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45532
GAK	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.707631
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01702
BRD-K36445086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82173
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19344
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_18hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.82811
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.27689
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00076
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3985
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66857
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A6NN-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A19037878_trichostatin A_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_16740_KO_Gcn5_SRP271119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7754
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37548
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39677043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38345
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.32402
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARG	ChEA Transcription Factor Targets	1.0	null
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.098797
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54154
TGM2_KD_GSE23702_716_human_NB4 cells, 72h ATRA-induced differentiation	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5487
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38413
NUGC-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05769
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4352617__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K07409609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27427
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19567
BRD-K41377239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15391
GSE93156_1_v_0_idelalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU175	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55948
BRD-K23316938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31069
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01796
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25222
Perturb_16700_KO_Blk_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.33172
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.886195
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33003
breast cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060956
NP118809	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47217
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110300,GSE110304_0_v_1_estradiol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99848
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10632
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.899898
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739724
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
CHLA57	DepMap CRISPR Gene Dependency	1.0	3.8207
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17660535-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952929
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A4-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sh-sy5y cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.518859
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11598
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42378
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NRF1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89738
EN	DepMap CRISPR Gene Dependency	1.0	2.28176
colonrectum_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.854365
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MUTZ8	DepMap CRISPR Gene Dependency	1.0	3.64854
ZC3H12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29907
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
diltiazem-5309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207359
FLCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709444
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0833
TP63	ChEA Transcription Factor Targets	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.97918
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6109
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.991699
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EM2	DepMap CRISPR Gene Dependency	1.0	3.32805
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832206
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24371
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
18794137-SuppTable1e	GeneSigDB Published Gene Signatures	1.0	null
PIK3CG_knockdown_96_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.70986
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0761
SNU349	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27129
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.0537
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4469	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17823660-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.13245
quinpirole-7481	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7391
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.908331
BRD-K36055864_CYCLOHEXIMIDE_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10638173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43599
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24624
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.0135
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15788
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.901326
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71352
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63664
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84095
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.28035
gramine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60023
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.76842
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5153-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.25105
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35061
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35681049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0576
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	0.870166
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229274
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.690887
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91836330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00211
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77885
MOLT-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551731
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH441	CCLE Cell Line Gene CNV Profiles	1.0	2.29691
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU46	DepMap CRISPR Gene Dependency	1.0	3.24729
GTEX-VUSG-2326-SM-4KL1U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971354
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-25	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0826-SM-4AD5E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896343
BRD-K04635516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50372
Embryonic carcinoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.856676
SIN3B	ChEA Transcription Factor Targets	1.0	null
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.117164
MAPK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00328137
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10577
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A00420644_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LY-294002-1236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37588
Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
isradipine-6347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25463
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44664
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04206
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67254
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.61284
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21313
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29292
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WK11-2726-SM-3NMAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870204
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866157
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07189
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.884193
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96549
SYNPO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614185
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95501793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00489
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.41573
GSE168807_6_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
homosalate-3797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.843065
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04797
lines	GeneRIF Biological Term Annotations	1.0	null
Mitochondrial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
Balsalazide (sodium hydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181968
Carbamazepine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0195625
acetylsalicylic acid-1204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3484
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97479
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55566
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33387
estradiol-1299	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE120595_0_v_1_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7125_KO_Prkce_SRP049245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.16032
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.904449
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.517
chr22_46586988_C_T_b38	GTEx eQTL 2025	1.0	1.91077
BRD-K51787437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17453
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13835
H3K36me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MERO14	DepMap CRISPR Gene Dependency	1.0	2.27712
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11566
UACC257	DepMap CRISPR Gene Dependency	1.0	2.24145
BRD-K35213218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05405
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.872068
FADU	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3452
SAOS-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
11707567-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.35563
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.03762
LGALS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00902081
BRD-K77627909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32016
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A9QD-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.1595
SKMEL28	CCLE Cell Line Gene CNV Profiles	1.0	1.6683
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	1.51033
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FAM124A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28229
fusiform gyrus, right, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09412
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207914_5_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58359
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2691
L540	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95759
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MutS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Flumatinib (mesylate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.047436
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09335
GSE210885_3_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07692
GSE140092_2_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124410_6_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76118
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prestwick-689-7173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO Biological Process Annotations 2023	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995568
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
HUNS1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25576
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95034
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
INPP5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691635
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983906
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12894390-Table1.xlsx-Table_S15-Table_S15_184_genes_shared_by_MI_and_HF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A34842997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49369
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.203275
GTEX-XYKS-2226-SM-4E3IU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942698
GTEX-XXEK-1626-SM-4BRUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11389
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12053
AMN 082	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.57
ERMAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701608
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23521
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50863
OXCT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00247861
Hypertension	CTD Gene-Disease Associations	1.0	1.01174
BRD-K73051782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0072
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07972
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983855
BRD-K00057967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11197
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49274
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62681
Perturb_3822_OE_Hras_SRP342740	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
T3M4	CCLE Cell Line Gene CNV Profiles	1.0	1.63272
neuronal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.734323
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.825824
KU812	DepMap CRISPR Gene Dependency	1.0	2.24347
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16482
TTC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25063
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
atracurium besilate-1824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944424
BRD-K90625628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14139
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057932
BRD-A92537424_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K52208857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09515
20460173-ImmPortAnti-IgMvsControl	GeneSigDB Published Gene Signatures	1.0	null
PMC12229841-Table2.xlsx-6mo_NS_vs_6mo_LPS-Negative_logFC_up_at_non-stimulated_Postive_logFC_up_after_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SSTR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00314165
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.23901
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.9622
BRD-K80210288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2053
Weight Loss	CTD Gene-Disease Associations	1.0	1.49941
RIPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00371339
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32782
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K73227539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28793
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.850562
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9946
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2975-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SCL-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00226
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.906729
hydroquinine-6263	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093971
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.842311
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0436
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24395
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.313
Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q5-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987063
BRD-K92431275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66734
BRD-K59633080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01057
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871048
chlorpropamide-6291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60733
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
OCIAML3	CCLE Cell Line Gene Expression Profiles	1.0	1.58925
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46078
gramd4	GeneRIF Biological Term Annotations	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23693
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7514
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37683
16166618-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GSE221386_2_v_0_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lomefloxacin-3723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
clemastine-7485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23404
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.054755
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XPVG-0926-SM-4B651	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933373
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209708
KMS27	CCLE Cell Line Gene Expression Profiles	-1.0	-2.41562
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71754
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49026
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.147543
BCHE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773561
SLC16A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30172
SLC29A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480142
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146074_9_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31210612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25693
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2178
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SRF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K39979171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59946
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.07768
Perturb_11992_KO_Tet2_SRP119769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.2742
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48882
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K66954388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23529
15988020-Table1	GeneSigDB Published Gene Signatures	1.0	null
trichostatin A-1612	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8624-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-527	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
Elimusertib hydrochloride_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0320691
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.911307
BAS-012416453-6876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HLA-DOB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481424
Tofacitinib (citrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0247642
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987269
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4685-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GTEX-U3ZM-1126-SM-4DXUB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918287
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSK2578215	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
NCIH1573	DepMap CRISPR Gene Dependency	1.0	6.67018
CSK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00324288
bisoprolol-1287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.885257
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01605333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22485
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
Goserelin (acetate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226199
RNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03661
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03696
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Docetaxel_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.020974
mafenide-5499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894938
KCNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00440374
BRD-K05357297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23057
hsa-miR-300	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30655
BRD-K45563993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74058
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73075
BRD-K04992384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29937
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21680192_mitoxantrone_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUJ4-1826-SM-4BOOU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830332
C1orf198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22689
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226983_2_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.974
hsa-miR-3922-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25041
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hep-3b cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.706812
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.209546
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.52857
GATA2	ChEA Transcription Factor Targets	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.919418
TMOD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583009
BRD-K52423731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42098
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910724
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845952
JURKAT	BioGPS Cell Line Gene Expression Profiles	1.0	1.15138
AR	ChEA Transcription Factor Targets	1.0	null
apoptosis	GeneRIF Biological Term Annotations	1.0	null
Perturb_1601_KO_Ticam2_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.00671
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A184-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OOBK-2626-SM-2HMKY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897626
COLO829_SKIN	CCLE Cell Line Proteomics	1.0	2.44717
GTEX-OHPM-1426-SM-3TW8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43648
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X638-0126-SM-47JZ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98556
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865102
AML193	CCLE Cell Line Gene Expression Profiles	1.0	2.35427
GTEX-VUSG-1526-SM-4KKZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72521
BRD-K56183302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46063
BRD-K17120673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18239
clioquinol-5258	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
10-methoxyharmalan-1743	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE203308_7_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4458
L33	DepMap CRISPR Gene Dependency	1.0	3.37389
medial geniculate nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.61094
RUNX1	ChEA Transcription Factor Targets	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961791
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0743
BRD-K83190598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.34173
LGMN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00381195
MHHCALL3	CCLE Cell Line Gene Expression Profiles	1.0	1.49196
STX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10769
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921718
AC-80-DI95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258527
vincristine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140647
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1084
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459313
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15815
GSE115363_3_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26691
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07005
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875491
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15847
Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPIC-0326-SM-4IHJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901522
Megalencephalic leukoencephalopathy with subcortical cysts	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-92b	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
BRD-K43170571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05732
BRD-K67931592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76483
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08482
PRMT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00810257
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849993
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.7808
H3K9me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0226-SM-4JBHG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4667
POR_KO_GDS1678_760_mouse_Colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.57006
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62713
GTEX-OOBK-0126-SM-2YUND	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835509
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824741
caffeic acid-6753	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LN235	DepMap CRISPR Gene Dependency	1.0	2.2388
BRD-K88385836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41567
BRD-K61315077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11964
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00076
Sigmoid_Colon	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.92518
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.99837
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33626
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9001
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19219
BRD-K90519599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21708
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2032
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46435
BRD-K15647573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0024
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905765
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Rucaparib (phosphate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189123
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60235
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903242
CACNG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569656
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.7241
icSARS-Cov_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.51267
palbociclib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156977
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.46532
localizes	GeneRIF Biological Term Annotations	1.0	null
Perturb_16713_KO_Prkab1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.81532
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.825927
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52N-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8155
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.06053
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.421
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68984041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1083
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0527
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052011
BRD-K93941597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48097
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.438
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TREX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613011
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tropine-6264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAP4K5_knockdown_199_GSE61497	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.36157
BRD-A39521712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14185
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
clorgiline-6659	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06029
GSE132948,GSE132949_2_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26465
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K06792661_Narciclasine_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38896
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3525
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.848779
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843473
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NCI-H596	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1717
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14889
PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	4.50558
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52961
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845952
BRD-K61092554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23261
ganciclovir-6289	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23816
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19431
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08034
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201815
Perturb_4312_KD_SMRT_ERP126775	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PTPN7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582764
SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.999269
GSE213588_10_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-Unnamed_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC251	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53486
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.46024
Perturb_1895_KO_Trem2_SRP173901	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.01634
RBBP5	ENCODE Transcription Factor Targets	1.0	null
LIF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00932372
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.975296
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088803
BRD-K75745696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66616
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909601
hsa-miR-4667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K64730761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64193
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Nearest_Ensembl_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL29	DepMap CRISPR Gene Dependency	1.0	2.05678
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0583
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Synostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863409
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.48754
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S33H-0826-SM-4AD5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870856
MELHO	CCLE Cell Line Gene CNV Profiles	1.0	1.72824
ARFGAP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452467
CRCGN008_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2792
TGM2_KD_GSE23702_713_human_NB4 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.27718
CORL95	CCLE Cell Line Gene Expression Profiles	1.0	2.24936
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09422
BRD-K53388755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50192
USF1	ENCODE Transcription Factor Targets	1.0	null
vigabatrin-6314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.623089
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.939285
hsa-miR-663b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
hsa-miR-636	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
FAM78A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635621
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7529
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10069
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04969
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.508424
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26373
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CD4+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0814
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MS (Multiple Sclerosis)_B Cell Lymphocyte_GSE10064	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.34525
STH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650807
nicergoline-6251	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Menadione_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0272612
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36345
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53J-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4464	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51785
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
induces	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11164
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0722
BRD-K31883990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21049
ROS	Kinase Library Tyrosine Kinome Atlas	1.0	98.82
12738660-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26136
PMC9314667-Table_1.xlsx-Regulons-HES6_HES6	Rummagene Transcription Factor Associations 2026	1.0	null
Hypopharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71352
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5928
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BLOC1S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3038
BRD-K37062347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67089
GSE124471,GSE124488_1_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cinoxacin-6257	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE140651,GSE140653_3_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL1	ENCODE Transcription Factor Targets	1.0	null
H3K9me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ripoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.337
DROSHA-22980978-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K67409155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05753
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42778
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A110-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RS411	CCLE Cell Line Gene Expression Profiles	1.0	1.61509
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24776
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4836-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8899_KD_IQGAP3_SRP359044	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POTEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00921
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344491
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14902
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
naltriben-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75831
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.46262
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926982
ES4	DepMap CRISPR Gene Dependency	1.0	3.09528
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4413
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12591
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06774
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pyrazinamide-2839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_XAV-939_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169312
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10123
Kaempferide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.48
BRD-K01275558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2423
GSE186460_0_v_2_baricitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sulfisoxazole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0280107
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07674
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22712
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC5997167__F5	PFOCR Pathway Figure Associations 2023	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.835317
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2619
organelle part	GO Cellular Component Annotations 2015	1.0	null
death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.708
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.483
Salicylic acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214105
PNU-0251126-3689	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE135309_0_v_1_tcf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3613-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KIJK	DepMap CRISPR Gene Dependency	1.0	2.73776
TRIM24_knockout_300_GSE19675	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.80257
CRCGN015_HEPG2_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19424
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847955
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
characteristics	GeneRIF Biological Term Annotations	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04199
GTEX-XAJ8-0526-SM-47JYK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20979
trichostatin A-1971	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183251_7_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14865132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65587
Perturb_795_KO_Tnfaip3_SRP332632	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.05573
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10486
Prestwick-1100-4534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TYRO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539906
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46203
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469801
DGCR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53837
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
MST1R	Kinase Library Tyrosine Kinome Atlas	1.0	98.1
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.478
GTEX-XUW1-0926-SM-4BONX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995183
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.94616
kidney disease	GWASdb SNP-Disease Associations	1.0	0.928472
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54666
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683511
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051175
BRD-K76415727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58685
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097933
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.81207
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91218
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX2	ChEA Transcription Factor Targets	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23521
hsa-miR-374b	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052177
HS936T	CCLE Cell Line Gene Expression Profiles	1.0	1.64811
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09615
CD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536223
Diammonium Glycyrrhizinate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0248791
icSARA deltaORF6_0Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.5803
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998086
BCL3	ENCODE Transcription Factor Targets	1.0	null
K562_Motesanib Diphosphate_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215762
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
hsa-miR-149-5p	MiRTarBase microRNA Targets	1.0	null
Small_Intestine	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.871005
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.1239
CRCGN009_HEPG2_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1795
AMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489884
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.52622
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.860716
alpha-estradiol-1635	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884089
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K23ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17588104_(-)-JQ1_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4697
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
A549_Triamcinolone Acetonide_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0072171
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18148
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056529
PMC4487811-mmc3.xlsx-siRE_enriched_geneLists-siRE_occupancy_pattern_gene_lists_after_RUNX1_ETO_knock_down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
naftifine-7273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
probucol-5261	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30912
trifluoperazine-1004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-218	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
APOL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663888
BRD-K67016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5494
EHBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82983
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71339292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60993
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K78812892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33497
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
IQSEC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516845
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0077
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AT-A5NU-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03337
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399361
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.89
regulation of apoptotic process	GO Biological Process Annotations 2025	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.10033
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052091
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8615-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TH-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85683
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253205
PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EP-0126-SM-3P5YV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909477
CDC42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1458
GSE110178_2_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01155
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20917
BRD-K97487406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13946
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE143643,GSE143644_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44405
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Clonidine (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173697
chr22_46630931_C_T_b38	GTEx eQTL 2025	1.0	1.91741
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41041
BRD-K90048234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31503
TAL1	ChEA Transcription Factor Targets	1.0	null
danazol-1954	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17715
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bcl2	GeneRIF Biological Term Annotations	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35362
GA-79-ZF28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242072
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88757
H3K36me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828935
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MC-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00734397
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K71561082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63634
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4067
A-Netherlands-602-2009(H1N1)_18Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.19414
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5641-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR0B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57243
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.863004
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.31756
GSE207914_0_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34353
HCC2935	CCLE Cell Line Gene CNV Profiles	1.0	1.38619
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903388
GSE158182_3_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02939
LAMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496237
Nuclear type mitochondrial complex I deficiency 33	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.642
Doxorubicin (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016184
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH292	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38672
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24842
IGF1_OE_GDS3484_542_human_MCF-7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24984
DIXDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17185
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13161
GTEX-XAJ8-0826-SM-47JY6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956722
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.859662
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31962
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26544
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15524
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293499
meropenem-7180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.918649
BRD-K54151058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19942
PILRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520302
hsa-miR-101	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K88636226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09046
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.828032
SKMES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47291
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06617
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.967278
DOCK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706742
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
15735721-SuppTable1a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	3.78163
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61882
BRD-K99470595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50839
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CHRNG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632544
TNFSF18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537065
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_S3I-201_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190133
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829822
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19971
BRD-K53489056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23658
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62221
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.04613
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850275
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-32	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085824
Allantoin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0333374
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2469
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4721
GSE247862,GSE247863_2_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cyclocytidine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69174
hsa-miR-653	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22232
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27711
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17425_OE_Gli2a_SRP141427	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.27652
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214514
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27483
BRD-K25761766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35157
BRD-K04257723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08444
Topotecan (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197429
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3605-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
trichostatin A-3114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7263-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFX_02_172	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60919
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89006
GSE130401_4_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IGR1	CCLE Cell Line Gene Expression Profiles	1.0	1.74724
IRGM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768199
NCI H226	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.882383
19755675-TableS6	GeneSigDB Published Gene Signatures	1.0	null
BRD-K54986816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15063
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
KDM2B-26808549-CHIP-SEQ-SUP-B15-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847203
Decitabine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027269
BRD-K22839533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52012
fulvestrant-7539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A817-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160304
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60460300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23149
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44006
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8I9-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atglistatin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.7
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55192
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84351
BRD-K04361415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66987
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5463
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888898
BRD-K43049540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12465
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JAK1_druginhibition_166_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.1058
BRD-K60107240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38217
GSE196540,GSE196542_4_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62218
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18275
BRD-K15602285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10583
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14337
LTBR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701596
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.03312
CFTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712237
DL-thiorphan-6249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5397
SW954	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RH30	CCLE Cell Line Gene Expression Profiles	-1.0	-2.14786
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Triclosan_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0281012
positive regulation of apoptotic process	GO Biological Process Annotations 2025	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5269
SIX4_01_269	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.17978
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249595
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.96774
SYNCRIP_02_10	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61358
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8507
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45379
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Levobupivacaine (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0178455
Sarcoma_SARC_TCGA-DX-A1KZ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63778487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59724
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.936153
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48306
hsa-miR-2964a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K50443235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53734
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277782
chr22_46626099_G_T_b38	GTEx eQTL 2025	1.0	1.83588
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11267252_CH5424802_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-USF2_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79332
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879534
Retinitis pigmentosa 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22784
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29363
Perturb_16086_KO_Bap1_SRP270239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.53657
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.606722
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67750179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14636
PPARG-20176806-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
anterodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0877
Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.990183
ADSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16936
BRD-K50190949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53307
Lung squamous cell carcinoma_LUSC_TCGA-77-8131-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25811799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94508
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.906156
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166129
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2889
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40536
breast adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092147
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LDLRAD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00750958
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5441-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53540914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59428
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02614439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8827
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.575081
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDR1_knockdown_169_GSE39207	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.97454
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10495
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NUP153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67257
all	GWASdb SNP-Phenotype Associations	1.0	0.033048
TIE2	Kinase Library Tyrosine Kinome Atlas	1.0	99.1
ROCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668703
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232494
PMC12824682-BLOOD_BLD-2025-028954-mmc2.xlsx-Table_S7-Supplementary_Table_S7_-_Consensus_MECOM-regulated_gene_list_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5842026-mmc5.xlsx-HIC1_directTargets_48h-Gene_symbol_HIC1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
BRD-K10505056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15107
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.858712
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0226-SM-2TF6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6532
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4401
PMC7921413-41467_2021_21650_MOESM5_ESM.xlsx-002_DE-CD34_Blasts_AP1_high_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967074
KYSE450	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60056
GTEX-O5YT-1426-SM-3MJHC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28304
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00054
puromycin-2448	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GUCY1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486416
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47219
GSE94849_7_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RSV-A2_24Hour-B6.129PF1_J_None_GSE18170	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.24673
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46078
FGFR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00771649
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07365
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
20380719-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17504
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
KLHDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20853
nimodipine-6480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
substantia nigra, pars compacta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.73055
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3356
atracurium besilate-1702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16802
bone disease	GWASdb SNP-Disease Associations	1.0	0.133952
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3655
GSE241108_1_v_0_sulfasalazine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LTBR_INHIBITION - 2 Days_GDS2004_734_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04674
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.997192
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211439
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51448
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.908889
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04389
RPL27A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14839
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23331
Perturb_14293_OE_Batf_SRP401628	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.78132
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14902
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE111102,GSE111105_3_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13235291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06124
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4811
IGSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644233
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HMB-Val-Ser-Leu-VE	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE111035,GSE111040_10_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01408
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7S9-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54922310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19609
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074561
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.623
BRD-K05957858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36217
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2994
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7067-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.06114
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00441017
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.08794
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80753
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.69299
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBL2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00332389
BRD-K00631971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75296
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9673
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.111578
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.246799
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62354
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.86791
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WHPG-2326-SM-3NMBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899435
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
indapamide-4335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Breast_vHMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.88503
hsa-miR-363	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
MYOG	ENCODE Transcription Factor Targets	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65999
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863918
Hyperplasia	CTD Gene-Disease Associations	1.0	1.20361
lithocholic acid-3816	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42911
GATA1	ENCODE Transcription Factor Targets	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080756
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14647
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83095019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24132
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03002
Perturb_8854_OE_ERG3_SRP034736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.40539
NEK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065603
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65481
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862544
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLVL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50707
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23369
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
oxolinic acid-5094	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9314667-Table_1.xlsx-Regulons-IRF4_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IL18R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762815
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S4P3-1226-SM-4AD4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45411
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040438
MPEG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602997
LIVF001-012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41044
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04859
Anastrozole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0311138
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLR20	DepMap CRISPR Gene Dependency	1.0	2.62304
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML3-CLOSEST_GENE_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65583
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM5_ESM.xlsx-Super_enhancers_in_T-ALL3-CLOSEST_GENE_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
tonzonium bromide-5678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADGRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.2492
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JHH7	CCLE Cell Line Gene CNV Profiles	1.0	1.51877
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565577
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877829
Lung squamous cell carcinoma_LUSC_TCGA-56-8622-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mifepristone-5827	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57138
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237689
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
PRRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46562
GTEX-R55C-1126-SM-48FCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36022
Centronuclear myopathy X-linked	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
hsa-miR-495	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
FGFR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571743
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44715
GTEX-T5JC-0426-SM-32PLO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16745
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11164
MET_knockdown_254_GSE38343	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.808059
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11476
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.91227
BRD-K13715646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33455
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447625
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23132
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-1426-SM-2TF4H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879954
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.98947
Perturb_1797_KO_Hif1a_SRP198677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.20677
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22165
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-9	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37238
LY-294002-996	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mimosine-5302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103124_1_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9464
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23521
BRD-K96209756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34583
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28357534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53987
EB-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05957
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897472
Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9096
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.934363
stachydrine-4469	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2043
U937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99631
Pseudomonas Infection_Lung Tissue_GSE923	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.43914
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML1-CLOSEST_GENE_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
KMS11	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6066
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32785
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05998
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
N6-methyladenosine-5332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K66254772_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75009
BRD-K70969650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10951
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SARS-CoV MA15_Day7-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.50098
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054743
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K55766625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76737
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1745
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20241
SLPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494611
hsa-miR-92a	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
L-Eflornithine (monohydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0301632
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.91341
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.30888
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978058
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.23127
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06029
HTR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062213
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL148	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43223
Penis_Foreskin_Fibroblast_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.23116
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A74Q-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LMTK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441776
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.835115
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222298
Perturb_5666_KO_Utx/Jmjd3_SRP339500	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.23123
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00478174
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	2.26545
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC42	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00393323
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1013
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70995
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09788
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050501
GTEX-XMK1-2526-SM-4B666	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14896
MV411	CCLE Cell Line Gene Expression Profiles	1.0	1.91532
GSE147210_3_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.5529
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0182
Mixed sleep apnea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
hsa-miR-135b	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51932
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40005
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.99837
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53981
JM1	DepMap CRISPR Gene Dependency	1.0	3.2783
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.4921
PMC5732738-oncotarget-08-103415-s002.xlsx-MFC-7_DEGs-Genes_with_significantly_different_expression_between_parental_MCF-7_and_GATA3_WT_clones_with_adjusted_P_value_0_05_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05308
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3479
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4311_KD_SMRT_ERP126775	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-18.0044
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.9969
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.18554
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.21014
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.088
LY-294002-1168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Clear cell adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36662285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55363
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03716
SK-MEL-31	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67777
BRD-K20722478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3403
SPACA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27985
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC50A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609111
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-REY6-1026-SM-2TF4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94621
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.832039
CAL72	DepMap CRISPR Gene Dependency	1.0	4.95646
SW948_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	15.7066
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28201
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961151
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.5982
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6922
H2810	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
5-Azacytidine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210487
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
FADU	DepMap CRISPR Gene Dependency	1.0	2.55287
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_1_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10338
HCC1806	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K18737347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12022
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12763
short insular gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13963
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CREM	ChEA Transcription Factor Targets	1.0	null
BRD-K44866331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04774
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XB-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85395
membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79517
PRKD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560176
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00946184
SCL-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53087
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.59511
hsa-miR-4659a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
USE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.239
GTEX-X4EP-0626-SM-3P621	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919526
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85939
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91109
bax	GeneRIF Biological Term Annotations	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1519
EZH2	ENCODE Transcription Factor Targets	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041168
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34388
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
KLF9_01_222	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.64004
Abiraterone acetate_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00956486
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dimenhydrinate-2400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959025
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07662
HDAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538466
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11042
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893548
medial orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.946993
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03865
BRD-K33986184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47286
Perturb_10738_KD_Ddx3_SRP324914	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957329
PMC7617265-EMS137094-supplement-Supplementary_Tables.xlsx-ST18-gene_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01039
GTEX-XUYS-0426-SM-47JX3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933798
PCDHB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36727
BRD-K50950731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0084
Acute Myeloid Leukemia_LAML_TCGA-AB-3000-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-608	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
SLCO4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530636
BRD-K84271229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18723
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.13511
EHHADH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00953304
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15385
BRD-A90249268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87493
DRD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673223
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon	GTEx Tissue Gene Expression Profiles	1.0	0.916206
hsa-miR-4734	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-R55D-1126-SM-48FEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827781
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08379
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.869061
TE10	CCLE Cell Line Gene CNV Profiles	1.0	2.21957
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50177754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00863
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64505
Varespladib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Cerdulatinib_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221784
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.916379
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4C_BATF3_downreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111102,GSE111105_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34525
GTEX-QMRM-1226-SM-447C6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921249
ZNF141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00438306
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAPK11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484556
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02902
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40441
ARL5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584032
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33105
NB10	DepMap CRISPR Gene Dependency	1.0	3.26756
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250025
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A183-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MQ-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EWS-FLI1-20517297-SK-N-MC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFG7-0626-SM-4LMK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840721
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33294
GSE207832_1_v_0_usp22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-361-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
SNRNP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11399
GTEX-UPJH-0726-SM-4IHJW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829088
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70688
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72549
TP53	ChEA Transcription Factor Targets	1.0	null
ebselen-5778	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NBTGR	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.2
TRKB	Kinase Library Tyrosine Kinome Atlas	1.0	97.5
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929454
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RRP7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41356
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13543055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67565
Lung squamous cell carcinoma_LUSC_TCGA-56-7221-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069529
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26169
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.24024
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8564-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGF1R	Kinase Library Tyrosine Kinome Atlas	1.0	98.18
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96968070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22453
hsa-miR-548x	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26572
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of programmed cell death	GO Biological Process Annotations 2025	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.032118
A549_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00777801
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14902
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DL-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL2RG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064247
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.742357
Nephroblastoma_Renal Tissue_GSE2712	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.91241
KCTD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08253
Perturb_14143_KO_Cblif_ERP002279	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.76383
BRD-K08109215_I-BET_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.98607
BRD-K85292767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39154
probenecid-2825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pentamidine-2834	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE84462,GSE84762_0_v_7_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.825007
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML1-OVERLAP_GENES_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17133642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02671
GB-19-AP57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257358
BRD-K01358985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22434
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A1NK-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847101
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hydroxytoluic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10959
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.939255
TOB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059073
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
betulin-7454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A38030642_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.03122
CW-051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66107
PMC9883165-41375_2022_1744_MOESM4_ESM.xlsx-CEBP_gene_module-CEBP_gene_module_with_gene_expression_data_and_ChIP_target_status_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1841
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNHIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0302
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE169571_3_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02419
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNX20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623795
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PTPN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01346
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
C1GALT1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587985
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1901
GSE140965_2_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF614	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21334
Berbamine (dihydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.019471
TBP	ENCODE Transcription Factor Targets	1.0	null
Perturb_4498_KO_Hnf4g_SRP139365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.1221
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.863331
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.66071
hsa-miR-634	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
LRRC15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637869
SLR25	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86554
bretylium tosilate-6674	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78902613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05367
Perturb_17415_OE_Gata3_SRP150425	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.6537
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-RNA-Seq_analysis_of_genes_associated_with_a_DHS_that_has_a_CEBPAx2_specific_Hi-C_interaction_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34738
CNOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20119
chlorhexidine-6302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NEURL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31182
GSE225141,GSE225143_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_CYC116_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248772
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00076
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13229082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60825
SFXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587993
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3128	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882503
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.98107
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17024
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.0847
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.16044
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848682
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	2.10901
GSE196540,GSE196542_2_v_5_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-2.49339
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.992994
Kanzaki disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.11295
Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00693
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE5	DepMap CRISPR Gene Dependency	1.0	4.33845
BRD-K52416366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56533
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829854
ceforanide-6751	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133642
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.940535
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50255
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12757
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24805
EM2	CCLE Cell Line Gene Expression Profiles	1.0	1.43336
H3K79me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-548am	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
Lung squamous cell carcinoma_LUSC_TCGA-96-8169-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_34_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BIRC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08755
TCF12	ENCODE Transcription Factor Targets	1.0	null
BRD-K34737616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12938
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8431
GTEX-S7SF-1926-SM-4AT5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20197
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937749
BRD-K31462164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69147
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12007
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37262
bendroflumethiazide-3415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57698
Perturb_1574_KO_Cul3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.34419
20386565-TableS1	GeneSigDB Published Gene Signatures	1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17823660-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QB-69-QH67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254879
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862424
regulation of toll-like receptor 9 signaling pathway	GO Biological Process Annotations 2023	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anisomycin-1304	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
p107_Deficiency_GDS3176_606_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
20460542-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
hand	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301039
Edema	CTD Gene-Disease Associations	1.0	1.02783
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11914
BRD-K02078984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12148
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4444
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38833
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAL1-20566737-PRIMARY FETAL LIVER ERYTHROID CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PDE-9i	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
Lung squamous cell carcinoma_LUSC_TCGA-56-8626-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Amsacrine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213977
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23923
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51391
BRD-A61864215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18902
GSE146747_0_v_1_nr4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BI-78D3_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0122162
Perturb_6564_KO_Gja1_SRP377031	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.006
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K01250897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06751
Lucanthone_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155767
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33389
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979974
SIN3A	ENCODE Transcription Factor Targets	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15403
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9221
BRD-K29420358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77124
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52745
1br3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7721
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200464
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23521
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.956357
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.30944
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-A83672804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12581
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Gata-6_KO_GDS4782_330_mouse_Adult heart during pressure overload	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5168-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.843022
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WY7C-2326-SM-3NB2U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20954
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
caspasedependent	GeneRIF Biological Term Annotations	1.0	null
BRD-K58245454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5441
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.837028
BRD-K50829918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42887
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58799
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01946
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Bisoprolol (hemifumarate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230206
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Curcumin_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127565
BRD-K07259155_NCGC00182362-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTPase activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.931
blood vessel	GTEx Tissue Gene Expression Profiles	-1.0	-1.43713
GTEX-WZTO-0126-SM-3NM95	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00446
Brain Lower Grade Glioma_LGG_TCGA-TM-A84J-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846963
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89448
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60924
GTEX-X4XX-0126-SM-3NMC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938613
Lung squamous cell carcinoma_LUSC_TCGA-21-1081-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	3.64096
BAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066277
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.864267
RPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89676
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20671
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
DBTRG-05MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01276
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12229841-Table2.xlsx-BL_LPS_vs_6mo_LPS-Negative_logFC_up_at_baseline_Postive_logFC_up_after_6mo_of_heavy_drinking_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50196
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1745
GSE216538_0_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ALK	Kinase Library Tyrosine Kinome Atlas	1.0	96.13
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SARS-BatSRBD_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.34172
GSE130383_1_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VJYA-2026-SM-4KL1K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901449
BRD-K03953354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2476
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82504878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38377
GSE146074_6_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247137
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31837
liver	GTEx Tissue Gene Expression Profiles	1.0	2.18987
SRF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13429
PHA-00816795-7076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE182680,GSE182683_10_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61371
FOXL2NB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19971
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.8597
BRD-K18074484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11595
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32568
BRD-K95712112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28425
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04633
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33589
BRD-K84792324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17139
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962585
HCC70	DepMap CRISPR Gene Dependency	1.0	2.91061
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39
BRD-K98418950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10936
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE146074_1_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CL11	CCLE Cell Line Gene CNV Profiles	1.0	1.66597
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42911
PMC4352617__F3	PFOCR Pathway Figure Associations 2024	1.0	null
ISG15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622588
BRD-K11672894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64844
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28981
GTEX-QLQW-0426-SM-447A7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71429
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210580_4_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14775
tissues	GeneRIF Biological Term Annotations	1.0	null
PMC12824706-BLOOD_BLD-2025-028441-mmc3.xlsx-Fig4B_genes_inc_expr_NRF1-gene_name_NRF1	Rummagene Transcription Factor Associations 2026	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CENPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00347
SARS-CoV_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.81688
Thyroid cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00816304
Lung squamous cell carcinoma_LUSC_TCGA-96-8170-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05995
hsa-miR-4651	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30409
BRD-K28752165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01877
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.23564
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sk-n-sh cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193885
BRD-K60521891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21085
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13368
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149760_0_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
amitriptyline-5453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.17464
BRD-K90694955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72266
C5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00376346
BRD-K13087600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27681
correlated	GeneRIF Biological Term Annotations	1.0	null
EED	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642225
BE-16-UV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287704
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06258
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6300607-41467_2018_7620_MOESM9_ESM.xlsx-common_BRD4-S_KO_MLL-AF9_loci-Unnamed_13_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03801
BRD-K71093375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01439
BRD-K35617935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31316
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
lung_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.01138
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20287
positive regulation of cysteine-type endopeptidase activity	GO Biological Process Annotations 2023	1.0	null
HLA-DQA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739506
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05132
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9500_KI_Trp53_SRP201382	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.61917
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32241
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.917849
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00213
BRD-K74445272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35718
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
GTEX-UPIC-1726-SM-4IHKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23996
WDR33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06271
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
IL6R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537491
GTEX-S32W-0926-SM-4AD5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920762
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4828-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PK59	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32592
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68455
K562_TG101209_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027509
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63188051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3451
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14023
Perturb_263_KO_GPX4_SRP255715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARID3A	JASPAR Predicted Transcription Factor Targets	1.0	null
amoxicillin-6285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
Adenosine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0128575
GSE153923_1_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41762421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34035
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24314
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Autoimmune lymphoproliferative syndrome type 2B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
BRD-K16079077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12994
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28305
SNU840	DepMap CRISPR Gene Dependency	1.0	11.96
fluphenazine-4461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3879
MAZ	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.24266
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.5789
FLT3	Kinase Library Tyrosine Kinome Atlas	1.0	98.99
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LRRC8C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691968
CASP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654609
GSE215314_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23693
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.212173
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
p73 transcription factor network	PID Pathways	1.0	null
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66002
LDHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00349536
GSE114258_3_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05068
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37136
Piroxicam_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185177
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3265
upregulated	GeneRIF Biological Term Annotations	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31868
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95287
GSE152432_1_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fusidic acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298491
hsa-miR-146b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20779
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504428
Perturb_12788_KO_Gba_SRP385574	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.16995
gliclazide-5089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.73934
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
N4BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68695
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.817516
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979162
PROC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531282
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SKMM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74104
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gemcitabine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0241755
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
edrophonium chloride-5001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06029
EIF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4427
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11706
theobromine-3334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-A4SR-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30298864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3683
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054049
JAK2	Kinase Library Tyrosine Kinome Atlas	1.0	96.17
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K48864953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62958
BRD-K51858914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2403
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1516
BRD-K77345736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25789
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.827807
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.65854
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.029947
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53932
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28956
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058502
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07024
TSC22D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24803
GTEX-XQ8I-0926-SM-4BOOF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09215
BRD-K66729666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40915
promethazine-6477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3049	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62361
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.315729
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.791557
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-A63501481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12059
ketotifen-5842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22661
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208318
Prestwick-1085-5774	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DGKE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30406
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-1826-SM-3NB1C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1153
Ivabradine (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232621
BRD-K70193997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21325
Cervical intraepithelial neoplasia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
WHSC1	ENCODE Transcription Factor Targets	1.0	null
IFRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82211
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GW311616	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869993
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0472
Pemetrexed_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0235258
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DROSHA-22980978-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC6300607-41467_2018_7620_MOESM9_ESM.xlsx-common_BRD4-S_KO_MLL-AF9_loci-Unnamed_12_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
20035825-TableS7a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K90852412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33815
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17814
Drospirenone_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0339357
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5132
BRD-K56131419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89245
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159128
GSE131425_2_v_3_arg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.479807
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256014
hsa-miR-211	TargetScan Predicted Conserved microRNA Targets	1.0	0.131849
BRD-K87213231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23564
BRD-K90359063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00605
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BN-01A-61R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.93103
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
18794137-SuppTable1c	GeneSigDB Published Gene Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
SAA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638251
BRD-K26461918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25384
HS751T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46899
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09999
Neoplasms	CTD Gene-Disease Associations	1.0	1.06808
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
SIK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485342
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72804
DNAJC2	ChEA Transcription Factor Targets	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901604
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3047
BRD-K32423836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24362
GTEX-RWSA-0826-SM-2XCBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5179
GSE114992,GSE114993_0_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939369
PMC7921413-41467_2021_21650_MOESM5_ESM.xlsx-002_DE-CD34_Blasts_AP1_low_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
dihydroergotamine-2081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51967
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05936
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZGPAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592222
Perturb_1079_OE_ZBED2_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06198
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16199
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50502
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07833
CFPAC1	DepMap CRISPR Gene Dependency	1.0	3.86233
localized	GeneRIF Biological Term Annotations	1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62256869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27512
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79261
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.4333
BRD-K19672435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46746
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87617
PRUNE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00814212
Phelan-McDermid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TCF3_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-2467-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-A67508925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01491
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.040763
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44675576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07269
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14775
flufenamic acid-5059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PAT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
PMC5390115-mmc7.xlsx-DE_Lists-H1-ECs_Experiment_2_H1-EC2_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34986
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150693
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95306
Lung adenocarcinoma_LUAD_TCGA-86-7701-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A61014366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36126
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.867623
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53744
PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_3_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
KNS42	CCLE Cell Line Gene Expression Profiles	-1.0	-3.33583
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67735
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71671197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15414
rheumatoid arthritis	GWASdb SNP-Disease Associations	1.0	0.714954
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XV7Q-1826-SM-4BRUV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01148
toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180652
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13969
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.17217
UBD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067809
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
embryonic cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE143643,GSE143644_3_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28765
Kidney Chromophobe_KICH_TCGA-KL-8346-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13439
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SERP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60695
BRD-K29728947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05498
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204154
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84952
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.434
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN011_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1354
K562_Carmofur_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177371
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09255
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A10523515_GSK-429286A_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10309
BRD-K32918816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24877
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06034
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40606
Carbidopa (monohydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231225
NRIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00800178
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941565
DUSP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0037681
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3TX-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rheumatoid arthritis	GWASdb SNP-Phenotype Associations	1.0	0.615542
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3356
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899006
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	1.42885
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46092
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885715
ADAM15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658295
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.87103
mcf-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223906
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38955
ADAM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661162
BRD-K56653679_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KIR2DL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485576
Familial isolated trichomegaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64392
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37818
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08687
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HL60	CCLE Cell Line Gene Expression Profiles	1.0	1.99248
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77104
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.880049
K562_BMS-911543_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185954
A-Vietnam-1203-2004(H5N1)_0Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.18667
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
nabumetone-5428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AZIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519957
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220262
GTEX-OIZH-1426-SM-3NB1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57946
MRC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506051
BRD-K56591923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12053
Triamcinolone_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210427
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-137	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98329
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	1.0	0.933612
ZG16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577785
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10076
NCIH1581_LUNG	CCLE Cell Line Proteomics	1.0	4.4195
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2569
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-1.03762
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18857
Canagliflozin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0170259
BRD-K28319429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87758
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200018
dichlorophen	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40361
2-Bromophenethylamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
17234769-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
BRD-K47869605_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tetracycline (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0327199
CRELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23649
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-374a	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4727-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49086
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85196
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212781
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11399565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24024
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05229696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09303
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16727
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.965608
hsa-miR-3119	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133683_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85110576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7973
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE248858_5_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00185
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of toll-like receptor 9 signaling pathway	GO Biological Process Annotations 2025	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.938
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272007
TTC38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10801
BRD-K24689407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44534
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28486
GTEX-TMZS-0126-SM-3DB9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877464
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	57.1034
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927483
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34963
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37594
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3153
BRD-K79090631_CGP-60474_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC44	DepMap CRISPR Gene Dependency	1.0	2.68346
STK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03707
BRD-K29331543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81928
UGCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576449
GSE151160_0_v_1_cd36_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897613
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.827897
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4748	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321977
CHD2	ENCODE Transcription Factor Targets	1.0	null
BRD-K03116744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23821
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21785
Pancreatic adenocarcinoma_PAAD_TCGA-M8-A5N4-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562593
BRD-K27008344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21209
Lopinavir_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0293939
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896542
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27055
BRD-K74971765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03371
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05052
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	2.02229
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FLOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14302
GTEX-NPJ8-0126-SM-2YUNR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979495
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04223
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	1.37434
BRD-K19590405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79919
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NCIH1869	CCLE Cell Line Gene CNV Profiles	1.0	1.4982
NOMO-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.034
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34929
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5248-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03229
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.8265
hsa-miR-500a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
LMBR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650514
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K22443456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49037
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548z	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
hMPV_12Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.51638
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	0.883708
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.225229
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06535
GTEX-W5WG-2426-SM-4LMI6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44524
Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0427
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052265
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1043
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21680192_mitoxantrone_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MALME 3M	BioGPS Cell Line Gene Expression Profiles	1.0	1.06189
BRD-A59985574_T542500_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A25687296_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5361-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glufosinate	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887778
Dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37185
GSE205021_3_v_1_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Abiraterone acetate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00921444
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1478
trichostatin A-2949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19641
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47374
ACTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04262
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC6A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03704
BRD-K92736140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27769
BRD-K13071687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9197
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12867
SLC35A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.057
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60483
TUBGCP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10734
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.940426
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70331
L-NIL	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4337-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NO10	DepMap CRISPR Gene Dependency	1.0	3.45787
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.825775
fenoterol-6331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CASP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551055
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217776,GSE217829_2_v_0_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860954
PMC9675280-12950_2022_317_MOESM2_ESM.xlsx-LPS_vs_control-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
azapropazone-7277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_11120_KO_Erg|Fli1_SRP402910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08905
KDM6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684396
Medroxyprogesterone acetate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0201528
lansoprazole-2967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01278504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00002
CRCGN014_HEPG2_3H:A11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17985
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.15865
Small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OU-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207914_3_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8941
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20152
Perturb_6385_KO_Tet2_SRP135297	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.37044
AU565	CCLE Cell Line Gene CNV Profiles	-1.0	-2.40057
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KAT6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00334135
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18139
sirolimus-6967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EIF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52678
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919749
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RET	Kinase Library Tyrosine Kinome Atlas	1.0	95.21
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10654
decamethonium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.72593
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27797
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.876014
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F4-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1918
H3K9me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72414522_AZD-5438_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22679163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.108
TAL1-20566737-PRIMARY-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42F-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137914_4_v_5_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35735
hsa-miR-204	TargetScan Predicted Conserved microRNA Targets	1.0	0.131849
SLR26	DepMap CRISPR Gene Dependency	1.0	2.88419
GTEX-RN64-0526-SM-2TC5P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834314
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15805
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10541973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19621
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6571
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24465
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nifedipine-7303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956956
Perturb_1902_KO_Malat1_SRP125035	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.25917
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05936
ARID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635691
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24414
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945306
noretynodrel-7471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00076
DCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688177
RXFP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520633
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02674
12086872-Table12g	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.30813
KCNK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674476
tanespimycin-1225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.847602
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.73493
Raltitrexed_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0382095
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831454
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
ENPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680102
hsa-miR-543	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00921
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54594
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8356
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12573
SNU410	CCLE Cell Line Gene CNV Profiles	1.0	1.74661
aklomide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68183
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989163
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316535
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4633
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929454
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.82427
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
praziquantel-3189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DROSHA	ChEA Transcription Factor Targets	1.0	null
CI-1040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68301
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.82087
GTEX-XXEK-2226-SM-4BRUM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986335
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	0.833463
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146074_10_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76335
helveticoside-3770	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XV7Q-1326-SM-4BRWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84356
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69229416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66375
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8431-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00006
EWSR1	ChEA Transcription Factor Targets	1.0	null
benfluorex-6727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04046
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0226-SM-3NMB9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95506
MDAMB453	CCLE Cell Line Gene Expression Profiles	1.0	1.53531
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Syndactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
RXRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00446
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33078
Sarcoma_SARC_TCGA-DX-A3UA-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
norethisterone-5055	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HTR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00809049
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00604
BRD-K06308228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54
CRCGN017_MCF10A.TP53.M_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0247
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5255
connective tissue disease	GWASdb SNP-Disease Associations	1.0	0.103086
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.11496
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.927761
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25702540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35926
BRD-K01916633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05096
BRD-K72135530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6021
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.11881
GSE132408_0_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051218
dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.504207
BRD-K36197756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21172
CRCGN014_HEPG2_3H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02164
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PIK3CA_knockdown_182_GSE46869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.1784
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3038
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11503
BRD-K88890050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04966
GSDMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51143
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3356
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.972765
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.02196
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03801
NUP54	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692527
BRD-K31275250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0072
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24292260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35499
HAPLN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499981
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1325
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.938755
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23197
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.886494
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252343
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4688
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.88286
PMC10350077-media-8.xlsx-PPM1D_tr_LPS_vs_Cont_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-4943-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K73364700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05132
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_3_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50278697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03048
finger	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301758
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21676
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36521
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.20719
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857897
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054835
Perturb_643_KD_FASTKD1_SRP299834	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.88074
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213746_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67830713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03498
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70237
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59941
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13688
Urate levels in obese individuals	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
SLC9A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505647
Perturb_16725_KO_Ncor2_ERP131241	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18233
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
19061838-TableS3	GeneSigDB Published Gene Signatures	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
vorinostat_homo sapiens_gpl6947_gse41504	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842782
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.85683
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8479
lung squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.892538
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600826
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87617
Lung squamous cell carcinoma_LUSC_TCGA-34-8454-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180951_6_v_5_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478047
GSE228181_0_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
METTL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575008
hsa-miR-3143	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.981541
ebselen-3458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.99111
GSE216538_0_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915805
BRD-K64571715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2734
MOLM-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31719
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
thiostrepton-2823	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hif2a_16565084_mcf7_lof_human_gpl2507_gds2761	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.28503
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19924
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976929
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11053
KLRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572355
Relugolix_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0300776
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52945
T24	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.21394
GSE248858_5_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72967
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85809
CRCGN017_MCF10A.WT.HP_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2566
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05999
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-A40504327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45058
ES3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10602
BRD-K77290793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60013
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15026
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.30538
GSE111102,GSE111105_3_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-330-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
BRD-K39348592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43339
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0035
HEC265_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.31409
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26872
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
JAK2_druginhibition_168_GSE38335	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.1058
BRD-K70712582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09284
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
naltrexone-2047	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_17423_KO_Cic_SRP126501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.9789
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75493
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921923
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TP-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89324382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07632
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223177
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12418
PSG6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674798
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.844692
prostate_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.828552
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thrombocytopenia_Megakaryocyte_GSE2527	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.751596
BRD-K47391428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03525
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180951_1_v_5_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-1126-SM-3NMBY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873581
LPS510	DepMap CRISPR Gene Dependency	1.0	2.56152
AH-6809-7075	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8669-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20247
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22541
Perturb_1176_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K07781799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76785
arthritis	GWASdb SNP-Disease Associations	1.0	0.286061
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-8116-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41009039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26489
Lung squamous cell carcinoma_LUSC_TCGA-85-8071-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mifepristone_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0428009
BRD-K67526257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.02181
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3397
Perturb_170_KO_Cebpd_SRP316336	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRAM domain	InterPro Predicted Protein Domain Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDUFS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91066
Perturb_3409_KD_Zbtb10_ERP123680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.301
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05593
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CADOES1	CCLE Cell Line Gene Expression Profiles	1.0	1.68344
H3K36me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4276	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.943217
hsa-miR-561	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4752
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30323
BRD-A50774520_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34143
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2974
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K43206373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26342
CRCGN017_MCF10A.WT.HP_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1544
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.844719
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.988828
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.883136
lynestrenol-1953	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_11925_KD_SPI1_SRP090090	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04302
Heart Diseases	CTD Gene-Disease Associations	1.0	1.10317
PMC4872073-supp_gkv1528_nar-02930-x-2015-File004.xlsx-Table_S2A-CREB1_Target_Genes_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGF1_OE_GDS3484_540_human_MCF-7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE143643,GSE143644_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06926
GTEX-XGQ4-2426-SM-4AT55	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04807
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00987
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9773_KO_Tkt_SRP313974	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.88671
hsa-miR-3656	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_JK_LPS-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04013
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61026
negative regulation of toll-like receptor 9 signaling pathway	GO Biological Process Annotations 2023	1.0	null
A549	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.44619
15-delta prostaglandin J2-2691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Berbamine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296006
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01602
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1869
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01641
Cardiac Hypertrophy_Myocardial tissue_GSE5500	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.941307
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966081
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.73694
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6293073-LSA-2018-00153_TableS1.xlsx-A_KD_Tr_1_3_DNAm-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
sulfanilamide-4474	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U8XE-1226-SM-4E3HN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834969
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18412
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83244
16622258-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21936
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8734
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
programmed cell death	GO Biological Process Annotations 2015	1.0	null
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54457
hsa-miR-367	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
CRCGN008_HEPG2_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.377
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22414
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922945
WDR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639255
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
YKG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12461113-HEM3-9-e70217-s002.xlsx-Table_S3-Model_4_top_50_genes_IKZF5_IKZF5	Rummagene Transcription Factor Associations 2026	1.0	null
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12025
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.891463
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.930569
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.908577
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MED6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04605
GTEX-R45C-1226-SM-48FEE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898758
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3232_KO_Pou2af1_SRP293293	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.191
RVH421	CCLE Cell Line Gene CNV Profiles	1.0	1.80038
Embryonic cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26288
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
endometrium_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05071
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89395
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94479
TLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15721
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900728
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06522
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.07266
BRD-K43271856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11963
GSE225656_2_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6497_KD_PIEZO1_SRP392492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_5_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17893
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824549
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16469
Chlorhexidine (diacetate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213078
valproic acid-1060	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25675728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3155
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.867
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K31479652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27497
BRD-K74677971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17419
TOR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27089
BRD-K18562194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66147
BRD-K08389897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09964
FGFR1	Kinase Library Tyrosine Kinome Atlas	1.0	97.53
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.661
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
intracellular part	GO Cellular Component Annotations 2015	1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57786028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13028
furaltadone-4313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRHR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665634
GSE205021_3_v_2_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ST6GAL1_Deficiency_GDS3151_608_mouse_Mammary tumors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00977
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17299
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.865383
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11405
COPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60049
TMIGD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630645
BRD-A77907596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28318
Perturb_6982_KO_Nlrp3_SRP173143	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35604
abnormal joint morphology	GWASdb SNP-Phenotype Associations	1.0	0.183719
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GGPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27174
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.85641
RCOR1	ENCODE Transcription Factor Targets	1.0	null
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cycloserine-7134	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.02503
GSE203131_0_v_1_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.845946
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93998
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79555018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53618
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50356
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.80568
miR-124_OE_GDS2657_771_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SUDHL5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61523
fenspiride-2106	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWCY-1026-SM-48TD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46413
lung disease	GWASdb SNP-Disease Associations	1.0	0.690819
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14087001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44939
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TD-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.878862
GTEX-OXRO-1726-SM-3LK6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939705
hl60	HPA Cell Line Gene Expression Profiles	1.0	1.85736
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZNF628	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08959
trichostatin A-1835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K98758203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16433
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNASE3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045672
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64542
RAD21	ChEA Transcription Factor Targets	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mozavaptan_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270271
HEXA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579668
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69768
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917602
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52104866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33651
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905711
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.914354
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10739_KD_Ddx3_SRP324914	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.48604
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170145
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22828
Roxadustat_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0311658
SW837_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.2948
GCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530368
PGAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646629
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18793
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0965
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43978
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76124
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00044
OCIAML2	CCLE Cell Line Gene Expression Profiles	1.0	1.59141
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900195
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.93008
Fluvoxamine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0278286
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15842
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.18824
GSE233679_6_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35326
GTEX-S3XE-1326-SM-4AD4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93448
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02915
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0827
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1099
imipramine-5440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sitosterol-4073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
verapamil-161	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cefazolin-7385	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59273
BRD-K20271299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33964
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66825
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04523
verapamil-6287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Edoxaban (tosylate monohydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0728422
Poisoning	CTD Gene-Disease Associations	1.0	1.11431
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846654
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A44S-01A-12R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Entrectinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0144327
GTEX-XPVG-2926-SM-4B66G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906767
GTEX-WHPG-2626-SM-3NMBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20378
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.931042
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1619
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JAK1	Kinase Library Tyrosine Kinome Atlas	1.0	96.43
D502MG	DepMap CRISPR Gene Dependency	1.0	7.4177
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
monocrotaline-7127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
apoptotic process	GO Biological Process Annotations 2015	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AML - Acute myeloid leukemia_Mononuclear Leukocyte_GSE2191	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.113289
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240205
GTEX-X4XY-0526-SM-46MW1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1903
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.831956
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06223
BRD-K64836560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19654
GTEX-P78B-1026-SM-3NMC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04634
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41605
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04895
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160373_5_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932013
GYPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542528
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02326
GSE149880_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39158
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77986
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858052
BRD-K77108738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22758
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27114
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61494
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-A78085235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53197
Perturb_5806_KO_GPR31_SRP117665	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.5018
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36748
GTEX-PWN1-1426-SM-48TDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2728
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231799_2_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251606
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27225
ICAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481855
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55804
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20069402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.525
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55F-0126-SM-48FCK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999667
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04253
CLOCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18654
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956589
Necrosis	CTD Gene-Disease Associations	1.0	1.35821
TXNRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629441
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84951
REC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27582
cellular process	GO Biological Process Annotations 2015	1.0	null
breast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056591
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989414
KIF21B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00450693
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4757-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
19605494-TableS3	GeneSigDB Published Gene Signatures	1.0	null
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6011-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43546
ECHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22172
SLC37A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90352
GSE196699_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14414396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50717
MYT1	Kinase Library Tyrosine Kinome Atlas	1.0	99.34
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223058
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KNS60	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88093
BRD-K36812047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24117
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
SUZ12	ChEA Transcription Factor Targets	1.0	null
HCC1195	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67025
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57167256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53807
POR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599277
midecamycin-1943	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3182	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062397
ADCY2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065151
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cefapirin-7142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985333
PMC9288051-13046_2022_2428_MOESM5_ESM.xlsx-Super_enhancers_in_T-ALL1-CLOSEST_GENE_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912009
Lung squamous cell carcinoma_LUSC_TCGA-98-8023-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
accumulates	GeneRIF Biological Term Annotations	1.0	null
remoxipride-6342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Posaconazole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265782
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.55774
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8087-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DKK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482176
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17285234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11569
BRD-K65166009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95548
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.4432
ZNF143	ENCODE Transcription Factor Targets	1.0	null
UMUC9	DepMap CRISPR Gene Dependency	1.0	10.7811
SCLY	ChEA Transcription Factor Targets	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.96866
profenamine-6697	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NALM19	CCLE Cell Line Gene Expression Profiles	1.0	1.41856
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06168
TEF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643457
CTBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14806
RBBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.40764
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100464,GSE100465_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38428
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HMCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89814
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00391791
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20192
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951913
A4FUK	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64383
TMIGD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621657
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-224	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
K562_Iniparib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170728
hsa-miR-4652-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K91084609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07852
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894152
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40939137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01463
hsa-miR-4652-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
Prostate	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.39973
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7251
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pralidoxime-6283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LM3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.939
KMS34	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7573
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	1.66037
AFD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722646
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
convolamine-5876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00428689
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ventral posterior inferior nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.16028
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1168
negative regulation of toll-like receptor 9 signaling pathway	GO Biological Process Annotations 2025	1.0	null
BRD-K16604360_R(-)-2,10,11-TRIHYDROXY-N-PROPYL-NORAPORPHINE_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5064
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3009-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81199760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55899
AAAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04975
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845952
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dip	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08249
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	1.0	2.8565
hsa-miR-548aj	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-VT-A80G-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052775
hsa-miR-2116	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-1926-SM-4E3IW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29378
BRD-K60918542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15118
RARG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101717
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2366
EJM	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12368
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
18537972-TableS2	GeneSigDB Published Gene Signatures	1.0	null
DNAAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32494
SIPA1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44748
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SK-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.3359
BRD-K95963125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34297
Idoxuridine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0286464
MAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692126
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.775
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05816
GSE111102,GSE111105_2_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181966_0_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11397
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HG-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITPKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665161
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.15154
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53301
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916907
CRCGN012_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0562
Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prostate_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.00694
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-518a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
INF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739292
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18163
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5124
HCMV_TB40E_24Hour_19951172_GSE14816	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.07097
Rhabdomyocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.07
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC25A20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535366
GTEX-U8XE-0226-SM-4E3J3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28877
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46482
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PDGFRA	Kinase Library Tyrosine Kinome Atlas	1.0	97.66
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923982
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-1233	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
e2f1	GeneRIF Biological Term Annotations	1.0	null
SKOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.655
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
zomepirac-4479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hepatocellular	GeneRIF Biological Term Annotations	1.0	null
changes	GeneRIF Biological Term Annotations	1.0	null
SMAD4-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80577041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35161
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06673
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20975
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1-FLI1-KDM6B_genes-Genes_associated_to_EWSR1_FLI1-KDM6B_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211963_0_v_3_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
u251mg	HPA Cell Line Gene Expression Profiles	-1.0	-0.966727
chr22_46611481_G_A_b38	GTEx eQTL 2025	1.0	1.27257
membrane	GO Cellular Component Annotations 2015	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.37015
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
MPZL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486501
Adrenocortical carcinoma_ACC_TCGA-OR-A5LG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63093217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40674
TSPAN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01583
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18546
pimosertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15771
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.899089
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
acetazolamide-1808	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
PLA2G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29647
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.61522
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89801935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38712
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glycopyrronium bromide-7386	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050782
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877905
RERF-LC-SQ1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K75618633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1787
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67893
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.88688
BRD-K78659596_MLN2238_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6-azathymine-3987	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.161999
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0436
CTCF	ENCODE Transcription Factor Targets	1.0	null
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47814
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39835
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.83661
Perturb_3389_KO_Tcf7_SRP217200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.70583
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838202
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.45439
hsa-miR-381	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055081
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70176
BRD-K10545066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66755
NCIH1092	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1633
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.972147
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5527
TYK2	Kinase Library Tyrosine Kinome Atlas	1.0	97.64
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_11256_KO_Nek7_SRP375473	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.78144
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Trametinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0124558
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0258
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52256
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39719
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.972314
Metachromatic leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48491
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23874
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8-azaguanine-1833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.811
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00805
BRD-K05400180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04268
IPCEF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613333
hsa-miR-223	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
DL-thiorphan-2752	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ1-1226-SM-4GICJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884844
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null