association	dataset	threshold value	standardized value
BRD-K00950228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35915
BRD-K52139780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28458
BRD-A96183603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09727
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K24178822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25503
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.9021
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3131
BRD-K11188962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65857
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1004
IM-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
LUC_FBS	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13316
BRD-K64404450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66194
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ALKBH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60795
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8794
BRD-K20377072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16537
496100303_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.10953
496100545_HIP_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82031
H2BC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08968
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44173
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K11671824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33412
BRD-K30038014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05668
BRD-K91818277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53817
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8226
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K57315740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2692
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1813
BRD-K58333451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10604
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32096
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19348
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36924
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76455
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46069
PPIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5369
BRD-K33151492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08632
BRD-K27915221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1975
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04934
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90446
BRD-K71391283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23593
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.272
BRD-K13637593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79516
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0525
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8049
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.94586
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN008_HEPG2_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19285
BRD-K04232710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60429
BRD-K76336129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98858
BRD-A67697194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00315
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34924
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.1832
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Schizont	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.081
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91054
BRD-K79684522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16608
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98877
BRD-K69984954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42371
BRD-K84178479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19151
BRD-A59995060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05133
BRD-K93486666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13702
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03285
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96995
BRD-K23585987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02245
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33232
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6793
BRD-K95763144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19783
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.3984
BRD-K45153693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47916
Endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-A95480808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18648
GOLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5978
External plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9871
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57542
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9874
BRD-K37144511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61514
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.913
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.1348
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG	Rummagene Transcription Factor Associations 2026	1.0	null
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K52713598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04761
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1941
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.313
GSE166004_7_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FJX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3347
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41196
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04801
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00387
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9508
ADGRG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79734
Dissociative amnesia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.213
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7267
EKC/KEOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
BRD-A26583774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03744
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57813
RTL8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12712
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K65564503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20184
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14189
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5091
BRD-K01286616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77597
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1585
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64147
BRD-K67007076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74839
BRD-K06058625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01319
BRD-K63420290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.423
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.08268
496100570_HIP_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61956
BRD-K33480200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28754
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.73431
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.17125
BRD-K94090114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65404
BRD-K88498468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20415
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74012
Dissociative disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.835
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.25
BRD-K06719105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20763
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6479
chromosome, centromeric core domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VCY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52806
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36515
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.5394
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1819
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.55275
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.54208
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4658
BRD-A83387524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32202
BRD-K72591075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14767
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05943
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75292
IMR-90 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RILPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21253
BRD-K63299069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0422
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9788
BRD-K70923850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50861
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.12435
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1815
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10957
non-Hodgkin lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6672
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4588
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75805
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95595
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7385
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1427
BRD-K76723780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01892
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.533
BRD-K21124684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3036
ZNF565	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59642
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
BRD-K36493118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53741
BRD-K63134971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36864
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4571
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8378
BRD-K02240568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44391
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CREM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28156
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2853
BRD-K54507743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17039
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1818
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64716
BRD-K23835343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07121
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.80164
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70071
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08013
TCL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6009
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2439
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6907
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5852
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33186
BRD-K43224838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14681
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6239
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12744
THBS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80637
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2419
BRD-K56381552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22771
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6526
BRD-K09206831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44288
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0728
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04737
BRD-K70302892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14776
PTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91041
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9758
BRD-A07214340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14504
BRD-K52731672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55692
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54283
PDCD2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46465
Trabecula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7747
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37873
BRD-K39224209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39937
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45471
BRD-A99990159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27966
Outer nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.873
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4366
BRD-K52552873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37308
BRD-K02321382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59403
BRD-K11823863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01219
BRD-K32485819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28369
BRD-K22487336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35642
ARL6IP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37262
PDCD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32813
BRD-K39913853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29803
BRD-K75281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07993
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.6586
BRD-K21937603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15277
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37876
GSE166004_3_v_2_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43524
BRD-K91628074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35134
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Arciform density	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.272
FOXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16462
BRD-K19474742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02649
BRD-K16304302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23195
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79777851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76128
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4203
BRD-K98841583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15072
BRD-K48053776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24839
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFE2L2_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62374815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0408
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9059
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23196
Sperm flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.148
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K83815133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06989
Ku70:Ku80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
BRD-K21936026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64534
BRD-K37900095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41835
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.44485
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01878
MXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40061
PMC4833939-13072_2016_65_MOESM9_ESM.xls-PU_1_KD_SAHA_SigGenes_txt-gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A94465834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89036
Hippocampus minor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
DNAJC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12683
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.514
CRCGN014_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02905
BRD-K07365255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33699
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42612
BRD-K04272258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04753
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56948
GSE217363_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06946
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4631
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2386
TENT4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06558
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7339
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18537
BRD-A17902629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57794
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58127
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.33555
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5491
CRCGN008_HEPG2_24H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27345
heterochromatin formation	GO Biological Process Annotations 2025	1.0	null
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34111
BRD-K11715561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05664
BRD-K66841501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53163
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.4934
BRD-K06162576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23913
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K00265832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22638
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15036
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DFFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7804
BRD-K56588599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58969
NHERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28469
BRD-K23196166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16524
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8214
BRD-K19387722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.01755
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62227
RAB4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60698
CRCGN016_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02622
BRD-K47599758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6693
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.764
BRD-K70618663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3913
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04251
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K08971733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00476
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0016
PAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64186
BRD-K71123535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20123
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.40566
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30541
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3234
furegrelate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05681
496100314_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12142
BRD-K74948793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82151
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.835
BRD-K04371719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25292
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2152
BRD-K49525275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50477
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0764
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3977
BRD-K97138361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1384
BRD-K09521953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24316
BRD-K76672145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47525
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2021
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.TP53.M_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06055
BRD-K47275094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32189
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79828
BRD-K69854611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19694
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23144
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0864
BRD-K05086663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60124
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18601
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00477
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05822
homatropine-methylbromide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12276
ARMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66715
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06772
BAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66013
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75325
IBA57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38436
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18056
IGSF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97917
COX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64307
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57893
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83978
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69785
BRD-K07502463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54589
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61984
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.12255
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0157
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8774
Primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
BRD-A17741195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92333
BRD-K56224420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29969
RNF170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.71153
RIOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.28868
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3177
496100445_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.79334
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.253
BRD-A63503250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26965
BRD-K06243138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08812
amorolfine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34362
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76902
HINT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80654
BRD-K41561756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30354
Subrhabdomeral cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.718
BRD-K96651591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1685
TP53I3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10307
BRD-A48478073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76176
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7729
Scc2-Scc4 cohesin loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.815
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19712135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47523
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3792
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78474
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14708
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24794
CRCGN011_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1027
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.75715
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27404
BRD-K00938872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34472
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77257
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.9758
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.917
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0489
496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.77625
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05038
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20315
BRD-K41033271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21133
BRD-K90877053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16277
BRD-K13350372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60858
ZNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6389
RecQ family helicase-topoisomerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.984
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.505
BRD-K02717912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11328
BRD-K20288742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09006
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37113
BRD-K15879529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07537
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6766
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10236
CRCGN011_HEPG2_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5037
BRD-A44046220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42742
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4444
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5672
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6875
BRD-K70264850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25204
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09332
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7468
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6951
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4624
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.178
CRCGN017_MCF10A.TP53.M_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22445
BRD-K56562541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07854
BRD-K85401814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43104
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7651
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.709
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18577
BRD-K65541951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10214
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3183
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
LIVF001-017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76845
BRD-K20415826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77023
HSPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76502
ZNF311	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98915
BRD-K44777226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13858
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7871
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2834
Peritubular contractile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
ZNF500	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88737
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.03949
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30165
BRD-K09405682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08923
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7454
NBEAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7913
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32906
BRD-K45237033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54426
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.24965
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AJUBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21144
GPAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30707
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1673
BRD-K97540907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22791
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.86083
BRD-A47798787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05702
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.33375
SRD5A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0587
BRD-K21997380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02213
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38742
BRD-K83122599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79756
ZNF362	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46028
BRD-A93436351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23873
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1B_HNF1B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30326216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11938
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0945
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2982
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9816
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98031
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.59354
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23775
CST complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
BRD-K20416270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02168
BRD-K97741413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9573
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0923
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93091
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04841
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.2119
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1215
Chromatoid body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
BRD-A77164655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19827
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.2659
BRD-K05796207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23563
BRD-K59841546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07635
BRD-K84277608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50856
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.TP53.M_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1153
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7193
ID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70678
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48608
Photoreceptor inner segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.596
BRD-K30917841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79524
RSP5-BUL ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.731
BRD-K44622259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58243
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CatSper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29171
BRD-K54134201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3165
CNOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88225
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38605
BRD-K75260889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24905
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.507
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39708
albendazole-oxide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91195
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68941
BRD-K04791118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37466
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3538
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05682
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05841284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04561
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47255
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8991
ZNF713	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39699
BRD-K88494268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30526
BRD-K30288714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09421
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.535
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.92853
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K73524144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03456
BRD-K50941255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27338
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06037
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K94442101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26036
BRD-K21232462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34868
CRCGN016_MCF10A.TP53.M_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12361
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STARD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59099
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6841
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K82637883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01427
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3889
BRD-K15940471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02387
FECH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81011
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8174
Galloway-Mowat syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
BRD-K71625503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37142
496100381_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63545
BRD-K91565112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61608
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7355
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DOT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55636
RSPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65604
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7533
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3417
BRD-K51600962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21433
GSE135352_6_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52272
GMPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85234
BRD-K63887881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36075
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.1924
BRD-K95591068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29519
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49771
CRCGN017_MCF10A.WT.HP_24H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03055
BRD-K22915992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25588
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24321898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1835
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6021
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42906
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14375
BRD-K07013504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70941
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.96571
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37977
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.71356
PDIA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52974
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8731
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2999
increased heart rate	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K39237487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12453
ZNF704	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09562
abnormal retina inner nuclear layer morphology	IMPC Knockout Mouse Phenotypes	1.0	null
CRCGN014_HEPG2_3H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5764
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09584
Synaptic ribbon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
Food vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.607
BRD-K82506716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32537
BRD-K45251081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07845
Rad6-Rad18 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
THRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83834
Acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10114
BRD-K63645840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33957
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3496
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF781	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87941
BRD-K37328981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30867
BRD-K99221119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29714
SAP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91125
BRD-K86998514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90342
BRD-A20242387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68133
GSE248858_4_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.6927
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11174
GDF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33704
BRD-K35491869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50663
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.587
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21231
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.39219
CRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23729
GSE210655_3_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5945
BRD-K56531121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1298
GSE143316_3_v_4_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04916
CRCGN016_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02862
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.15807
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.80712
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24303
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9099
BRD-K30615964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1436
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92884
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1576
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91763
BRD-K41798816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50644
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9887
VAC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53464
CRCGN017_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38015
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.108
BRD-K83919473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28871
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83229680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02198
Meiotic cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
BRD-K84239940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37028
BRD-K96505704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41633
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4335
BRD-K86884344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.78733
BRD-K65441343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65115
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65435
RIOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49196
BRD-K76539747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25788
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0379
496100521_HIP_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40616
BRD-K66700691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05936
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.068
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80165
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13547
BRD-K31059261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84334
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68152
BRD-K53632480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38053
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K08138210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55202
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5035
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.92308
BRD-A89575866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78254
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96015
BRD-A71722688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61893
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.7781
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.5403
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59639
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73261
BRD-K92712671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66236
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6563
BRD-K92725027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14447
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.81009
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3574
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9115
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50105
BRD-K16357911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76704
BRD-K57115335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31791
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28715
BRD-K90999585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29593
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76628522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2881
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
METTL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95019
BRD-K12411112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06532
BRD-A77181042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3317
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5694
BRD-K03321770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29487
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3435
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1814
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0653
Creb5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.7502
BRD-K96997646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54647
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84012
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93965
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.00153
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.89825
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.106
BRD-K69826976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15678
BRD-K66717300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22432
BRD-K00767817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34778
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25318
BRD-K75772626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31341
BRD-K48676303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02109
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24892
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5237
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81648
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59846
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01524
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K76197651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34628
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6676
OGFRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61361
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4912
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	62.1777
BRD-K64380616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05131
BRD-K82102352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7297
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22873
BRD-K87080232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02951
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.716
BRD-A26165232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14278
Sex chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.985
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64561
CRCGN014_HEPG2_3H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14364
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4082
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51549
EID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66236
BRD-K77144444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1076
BRD-K52123140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92003
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06615
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.7902
SPDEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57663
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56736
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44617
496100503_HIP_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61558
496100489_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67234
BRD-K81001899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22931
BRD-K05796780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13759
BRD-K68580555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66963
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.6515
CRCGN008_HEPG2_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08185
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1963
BRD-K45042519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32923
ELOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06848
BRD-K33350866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05708
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33564
Gall bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Outer acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.86448
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.145
DNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95115
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6783
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	54.7778
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08615
tylosin-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.12961
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.9069
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2763
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32564
BRD-A53850583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70865
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3372
BRD-K96218183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17644
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41696
BRD-K67096761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85935
BRD-K79982586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07218
BRD-K15742845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20942
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29881
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3468
BRD-K11573765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11425
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02393
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11095
CRCGN011_HEPG2_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37065
BRD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.41136
BRD-K31577322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29038
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13573
PMC3804941-supp_jem.20122709_JEM_20122709_TableS1.xlsx-Suppl_Table_1C-1772_genes-Table_S1_C_1_772_significantly_overexpressed_genes_during_AR_when_combining_p-values_at_FDR_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5597
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0806
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7606
ETHE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27391
GSE191105_0_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86268010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2476
BRD-K22229548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56448
HSD11B1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00463
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.607
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4789
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5545
APOBEC3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89653
ZNF784	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2203
ENPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26821
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0394
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05175
Endocytic patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7445
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3579
BRD-K61553312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0979
Actin cortical patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.544
BRD-A88461048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33601
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74699
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2042
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5002
BRD-K47508820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16611
Ovary	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63992
GSE166004_1_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20552
Npas4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8041
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2366
Slx1-Slx4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71091
PPP2CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66843
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1228
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22154
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0436
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40687
CRCGN008_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13955
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K28510065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42662
negative regulation of gene expression, epigenetic	GO Biological Process Annotations 2025	1.0	null
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28828
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8928
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0056
BRD-K96764878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.84363
CCDC82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20412
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9444
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.209
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.58805
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.845
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.279
Pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K60053695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2113
BRD-K62472719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62338
BRD-K90741031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83519
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8336
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.17513
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_HEPG2_48H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22595
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71819
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26921
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2587
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7486
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.07149
BRD-K33787033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6598
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.65294
BRD-K68665079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64356
BRD-K86192746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.05639
BRD-K64904523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81009
BRD-K96384208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06624
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14415
BRD-K72359187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97626
TRA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77489
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62739
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3412
BRD-K13068347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32511
BRD-K96713984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00692
SACS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94904
BRD-K49328983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.833
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K21176717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22387
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55078
BRD-K13257316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13714
CENP-A containing nucleosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.603
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38245
BRD-K12665145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55042
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53191
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.849
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K78642007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08832
BRD-K39342915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18704
MYT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89743
GSE164726_0_v_1_phf10_human	RummaGEO Gene Perturbation Signatures	1.0	null
LTB4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75568
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K38975326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15728
BRD-K06935782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31374
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85899
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16235
toxin-antitoxin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.562
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9296
CENP-A containing chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8796
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7469
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6679
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.43885
BRD-K54538111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69273
PMC12304111-41598_2025_13196_MOESM5_ESM.xlsx-Sheet_1-Table_S4_DEGs_Log2FC_1_and_p_adj_0_05_in_pancreatic_cancer_with_high_versus_low_OVOL1_expression_OVOL1	Rummagene Transcription Factor Associations 2026	1.0	null
Internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Testicular somatic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
BRD-K94915822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01522
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3118
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.04188
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
496100388_HIP_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40611
BRD-K73874262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78078
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8658
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8311
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24861
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.69649
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9291
496100518_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71765
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32276
Secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.58353
BRD-A48228341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07572
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17621
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16171
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.342
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76323
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1256
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10826
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44705560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8112
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37622
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.75822
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43235
BRD-K33940145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67787
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72328
BRD-K84459640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26366
BRD-K38118226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71819
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HSPA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30301
BRD-K67177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32557
ZC3H12D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61274
BRD-K06845853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01588
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9916
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0958
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10204
Fetal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RAB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52072
TRIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92384
BRD-A23955117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31035
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null