association dataset threshold value standardized value EDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68389 Lower respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 ADD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3249 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-DREAM_target_genes_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null Lung cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 NFE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25267 CSTF2T CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05404 AGMAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66048 SF3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47493 GPR176 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81532 PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null NUP153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7736 ECHDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60151 PRRC2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81937 BHLHA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53303 SLC25A45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75793 Melancholic depression DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 Lupus erythematosus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 Respiratory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 MAFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05193 NRROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64087 ZNF703 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34724 Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 TFRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28262 GNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54345 PMC7863452-12920_2021_883_MOESM2_ESM.xls-SRG_23_HCC_vs_17_NT-GENENAME_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 496100643_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.37265 RIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71293 PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null PIK3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67045 SCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2496 Anxiety disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.635 CEBPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57804 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 NBPF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75641 ZNF543 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22568 DPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94262 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.13 TBC1D22B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93785 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 ZNF431 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1633 Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.024 MUC3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95812 NUP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37704 AGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26154 PMC7672319-mmc3.xlsx-DREAM_MSigDB62-FISCHER_DREAM_TARGETS_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null NUP188 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26934 EEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59142 GALM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47322 MRNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35765 DFFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30625 UBFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11029 NOM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22973 SLC35A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08087 BNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07189 496100460_TCx_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01208 EPDR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09955 TATDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11762 NIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25569 VHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32837 SNPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11736 C2CD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10494 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.249 APAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.59301 PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9 Rummagene Transcription Factor Associations 2026 1.0 null PMC8554867-12885_2021_8839_MOESM2_ESM.xlsx-Table_S5-Table_S5_Correlation_of_upregulated_genes_Table_S3_with_FOXM1_FPKM_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null Lung carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 ZNF157 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98424 Fanconi renotubular syndrome 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.882 FBXO28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13224 POU6F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30478 ATP8B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32327 MINDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9639 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.351 FAM200A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60822 ZNHIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53634 NDUFS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30984 PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null ASH2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65881 NRBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34421 DLAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04089 TMEM82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73899 SRRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69647 PTPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96635 BRWD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68177 Reproductive system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.915 CDC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39605 PMC4677459-NIHMS65392-supplement-Dataset3.xlsx-HIF1A-Unnamed_2_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null APLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.846 DHX33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4612 Extraocular retinoblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 PARP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55182 SLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2663 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 ASPHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00607 Thyroid GTEx Tissue Gene Expression Profiles 2023 1.0 7.21239 Lymphatic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 POLR1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88402 RAD51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93168 TOP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.539 GGN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49481 GIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33838 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_29_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.024 PMC7863452-12920_2021_883_MOESM5_ESM.xls-SRG_13_GE2-HCC_vs_17NT-GENENAME_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null SFPQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77623 C3orf38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80225 ERGIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46313 MRS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47559 MBD3L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05735 PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B Rummagene Transcription Factor Associations 2026 1.0 null CYP27B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50567 ABT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54274 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.325 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21993 PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59447 CDC42EP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38811 496100490_HIP_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.12079 TTLL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18396 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.248 SLC16A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.93739 ZNF526 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34245 NSUN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38396 MAP3K12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62414 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.264 RHOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14024 NOSIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58368 ZBTB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13369 Nucleotide excision repair in xeroderma pigmentosum WikiPathways Pathways 2024 1.0 null CFAP119 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55415 NEFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72945 PMC6890746-41598_2019_54845_MOESM4_ESM.xlsx-LBX2-AS1-Unnamed_1_LBX2 Rummagene Transcription Factor Associations 2026 1.0 null CTSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13223 TNKS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50383 MFSD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1398 SLC25A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86494 IDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55992 CUTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09273 GTF2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04013 LIG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68769 Depressive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 PIAS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04917 Lymphatic system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 CDC25A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3536 PGM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20586 Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 CBLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22188 Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 RPL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16672 H2AC25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47246 EIF4G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13919 TPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22721 CFP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26234 UBE2T CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20142 SCYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07263 PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_BOUND_BY_MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null SMCO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70044 ATXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59609 DOLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31791 CCNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50885 ASPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53386 RNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21369 PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null TIMM17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64336 SSH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35337 METTL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35311 ZNF749 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37397 PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43942 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.29493 CASC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92679 Chronic obstructive pulmonary disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.245 ZNF281 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42152 ZMYM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51593 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.65 MRM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26396 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.065 Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 G3BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39299 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.696 PMC7069022-Table_1.xlsx-MYCN_Cor_Microarray_Analysis-GENE_MYCN Rummagene Transcription Factor Associations 2026 1.0 null PMC2694838-1471-2164-10-241-S3.xls-Sheet1-Commonly_altered_genes_by_ZNF191_overexpression_and_knockdown_ZNF24 Rummagene Transcription Factor Associations 2026 1.0 null PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null PPP1R14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25552 PAQR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43721 PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN Rummagene Transcription Factor Associations 2026 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.279 RAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17238 KRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40218 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.753 SLC12A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61561 PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null RIMKLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7846 PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2 Rummagene Transcription Factor Associations 2026 1.0 null ABCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73351 PURB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30323 NAGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41101 Obstructive lung disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.245 Viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 PMC10879698-mmc1.pdf-12-ZNF432_ZNF432 Rummagene Transcription Factor Associations 2026 1.0 null Juvenile pilocytic astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 PMC11585558-41467_2024_54547_MOESM8_ESM.xlsx-TP53_vs_WT_DEG_FFPE-gene_name_TP53 Rummagene Transcription Factor Associations 2026 1.0 null RNF149 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5899 GTF2H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95795 Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 RECQL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44912 DENND6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43557 MEF2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61455 IQSEC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63768 RAB40AL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.33956 BLM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23343 BCKDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41875 FZD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72893 CSTF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91629 Hereditary spastic paraplegia 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.122 PMC8370976-41467_2021_24932_MOESM6_ESM.xlsx-Annotation-Supplementary_Data_4_GO_and_metascape_analysis_of_the_genes_downregulated_in_U87_cells_upon_ZNF768_knockdown_ZNF768 Rummagene Transcription Factor Associations 2026 1.0 null LSM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3587 Squamous cell carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.574 PRRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54834 Atrial heart septal defect 6 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 DIMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.88683 Lung squamous cell carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.574 EID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69006 FDXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78136 PIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02925 XRCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77053 PRRC2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38147 LRR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2517 PMC11938024-ADMA-37-2413413-s001.xlsx-Table_S1a_DE_Genes_analysis-Table_S1a_Differentailly_expressed_genes_Control_vs_NPs_treated_THP1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null ARHGAP45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19575 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.071 PMC4149371-pone.0105180.s010.xls-OCT4-GENE_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 RPP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44798 UHMK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48273 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 SCG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67403 ZNF43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32799 IER5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16275 SERHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.53885 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.316 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.202 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.218 PHACTR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11409 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 TEKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92586 NKG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62527 ATG16L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4651 WDR83OS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18343 RAB11FIP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89501 UBE4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22593 GMCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58348 PRMT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66408 ZIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44636 KRI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15389 PDCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82919 Immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null GBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.92675 MAPK1IP1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69405 SPATS2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50375 Cell type cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 PYGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23665 ZC3H12C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.782 AP3M2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40594 Systemic lupus erythematosus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 PRRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98754 PMC8755726-42003_2021_2958_MOESM6_ESM.xlsx-489_corr_genes_TWIST1_signature-Gene_name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null LRSAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93446 MRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27225 H3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55374 PMC12480273-12672_2025_3611_MOESM1_ESM.xlsx-csgene-TP53_TP53 Rummagene Transcription Factor Associations 2026 1.0 null FUZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28779 EVX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94143 Carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 PMC8758144-elife-74272-supp3.xlsx-AP1_REP1-GeneName_JUN Rummagene Transcription Factor Associations 2026 1.0 null AAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84187 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.018 FAAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20576 QRSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34554 RASAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4037 Major depressive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 COQ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48148 PMC7863452-12920_2021_883_MOESM6_ESM.xls-SRG_13_GE2-HCC_vs_10_GE1-HCC-GENENAME_CASZ1 Rummagene Transcription Factor Associations 2026 1.0 null VENTX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32188 C21orf91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47576 CHDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30068 ZNF81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29348 CISH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75015 ATXN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01892 PMC4975902-12864_2016_2842_MOESM12_ESM.xlsx-targets_of_IRF8_in_NSCLC-COX7C_IRF8 Rummagene Transcription Factor Associations 2026 1.0 null ATP6V1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01301 USP27X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62236 TMEM240 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61675 ETF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55686 NRIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94459 CNOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64595 Autoimmune disease of musculoskeletal system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.08 DNAAF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32494 PMC7806950-mmc2.xlsx-KRAB_Significant-DEGs-Table_S2_Significant_DEGs_following_targeting_of_dSaCas9-repressors_to_DUX4_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null RFX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43932 ASS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80918 PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 UBXN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05937 SYDE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18305 H3C15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30219 DHPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57021 GRB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33868 TLE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38978 NAGLU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12198 PCGF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07292 CWC25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14796 PMC12821819-40478_2025_2173_MOESM9_ESM.xlsx-Supplementary_Table_3a-Supplementary_Table_3A_List_of_Top_1000_Genes_with_the_Highest_Stochasticity_by_JSD_in_the_ATRT-MYC_Subtype_MYC Rummagene Transcription Factor Associations 2026 1.0 null IRX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09264 PMC9434001-Table_1.XLSX-Sheet_1-ZBTB7B_ZBTB7B Rummagene Transcription Factor Associations 2026 1.0 null SLC25A44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05289 MEF2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24525 GOSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0652 PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2 Rummagene Transcription Factor Associations 2026 1.0 null PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2 Rummagene Transcription Factor Associations 2026 1.0 null R3HDM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54425 PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG Rummagene Transcription Factor Associations 2026 1.0 null SLC17A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45532 496100407_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19697 STIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30027 TPCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94297 FANCM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4225 SLC35B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42312 ETV7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53533 MRPL20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23687 Histone modifications WikiPathways Pathways 2024 1.0 null Acne DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.621 TLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65833 TMEM63A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31952 SLC35D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22101 IRF2BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21002 HDX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52891 FMNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52849 Skin disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.621 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.149 LMAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08398 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 PMC9899501-NIHMS1869252-supplement-Table_S4.xlsx-REACTOME_CUTOFF_2_5_TOTAL-HAND1_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null GINS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83189 ATR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83225 PALS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19868 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 SNRPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28187 496100648_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.15878 SH3BGRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43749 Sebaceous gland disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.621 MLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.53728 Male reproductive system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.915 PTTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48686 NSA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25395 C2orf81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99577 Pervasive developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.65 CCDC137 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14649 ZCCHC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17546 TST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39984 MIS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58648 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.071 Intraocular retinoblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.256 NCOA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48074 ESCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61561 PDHX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00014 PMC11960529-mmc4.xlsx-Atrial_LHX2_KOoverCT-gene_LHX2 Rummagene Transcription Factor Associations 2026 1.0 null PXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97505 Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 Cognitive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 KCNJ14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37215 Prostatic hypertrophy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.915 PTPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31799 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.254 PMC4029819-pone.0098069.s004.xlsx-SAM_FOXA1_h_vs_FOXA1_l-Table_S3_SAM_analysis_of_FOXA1_high_versus_FOXA1_low_cases_FDR_0_01_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF532 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63106 Autism spectrum disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.65 Mood disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 2.037 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 496100358_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.99996 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.812 ZNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25239 PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null GINS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58825 MST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34891 PMC7806950-mmc3.xlsx-Sheet5-Table_S3_Comparison_of_DEGs_following_targeting_of_dSaCas9-repressors_to_DUX4_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null Avoidant personality disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.502 ZNF709 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37849 PDCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30328 PMC11568168-41598_2024_79607_MOESM3_ESM.xls-11-E2F1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null 496100622_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08895 EIF2AK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17494 PANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25499 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 TMEM126A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5389 HSPB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33015 STX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01859 VPS26A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09955 ODF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31018 PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2 Rummagene Transcription Factor Associations 2026 1.0 null LSM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80479 DYRK1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48869 PPP1R2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60839 PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null UCMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78638 PMC11519470-41467_2024_53624_MOESM1_ESM.pdf-52-TWIST1_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null 496100483_FWM_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.55507 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.439 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 EIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88651 POP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30632 UBQLN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44977 TM6SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48677 Unilateral retinoblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 FBLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64254 PMC6890746-41598_2019_54845_MOESM4_ESM.xlsx-LBX2-AS1-Supplementary_data_3_Co-expressed_DE_PCGs_with_top_lncRNA_LBX2-AS1_LBX2 Rummagene Transcription Factor Associations 2026 1.0 null SMAD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31057 UNC119B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85074 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 OTUD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3895 PANK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25617 VAMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43037 CDC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63376 PLCB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27226 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.245 PHTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.232 CREBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33558 Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 CFAP36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26088 RNF170 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48875 WIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33592 THAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36879 PPFIA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43709 PALB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3664 PDE5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07916 CCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20789 XAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52575 Bipolar disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 CLDN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10294 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 EIF2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02647 TOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32238 EXOSC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02704 RPL37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13134 HIKESHI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35717 PMC10290283-biol-2022-0622-sm3.pdf-325-TCF7L1_TCF7L1 Rummagene Transcription Factor Associations 2026 1.0 null Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.065 YDJC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23295 TMEM123 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56253 496100465_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1064 PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR Rummagene Transcription Factor Associations 2026 1.0 null Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 UPF3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92235 496100393_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46664 PMC3029394-pone.0016617.s001.xls-Down-regulated-Table_S1_Genes_down-regulated_by_SOX2_over-expression_0_5-fold_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null SCNN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27382 Respiratory system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 PMC4677459-NIHMS65392-supplement-Dataset3.xlsx-NFKB1-Unnamed_2_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null Lung non-small cell carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.574 FAM168A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79749 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 NOP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5078 C4orf46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47123 POLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62631 ZNF439 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47933 ZNF804B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57323 ZNF148 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74897 PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null ARPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08953 ZNF569 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14016 ACSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35484 Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 ZFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61918 DLGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18473 ALX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83092 Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 C18orf21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0916 DCAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52671 NOCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.923 ABCB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67532 PMC7239701-aba1334_Data_files_S1_to_S3.xlsx-FIG_2J-SHC-MSC_transcriptome_enrichment_genes_MSC Rummagene Transcription Factor Associations 2026 1.0 null GOLIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5978 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null PTF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55654 Lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 SLC25A22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72227 PRPF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3922 TSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62746 KLF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09207 MTLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31328 NF1 copy number variation syndrome WikiPathways Pathways 2024 1.0 null LSM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35001 PMC6433297-pbio.3000178.s012.xlsx-DREAM_targets-BUB1B_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null ZNF682 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81137 TOMM40L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43432 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.245 STAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67922 PLXNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25705 POLR3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21838 post-traumatic stress disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.635 INIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15498 KLHDC7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63323 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF845 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01404 TRMU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01849 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.665 Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.032 CCM2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 496100322_FWM_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19715 YPEL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05356 MTERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02021 ZSWIM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05762 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.366 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.692 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.49 PRKAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64492 ZNF736 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41783 ZNF598 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40169 HBS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67484 CCNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95316 ATAD3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00567 ACTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19056 DDX39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2289 Senescence associated secretory phenotype SASP WikiPathways Pathways 2024 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6309 DDX47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02299 APELA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35762 EMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53761 PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null MGAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33508 FOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63983 Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.286 Alpha thalassemia-X-linked intellectual disability syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 ZNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21118 PPP1R15B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39962 TNFSF13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52866 BCAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62999 UBE2Z CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73414 PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24 Rummagene Transcription Factor Associations 2026 1.0 null HSF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25904 THBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21487 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 ESPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49004 Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 WDR20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04808 Lung disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.38 PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null HAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3218 Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 Prostate disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.915 Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 Integumentary system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.621 CHRNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18835 RPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72383