association	dataset	threshold value	standardized value
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.2325
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.228333
ARF1	Pathway Commons Protein-Protein Interactions	1.0	null
AC-91-WE67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268221
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238258
7163_RBM19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.860131
PMC5082879__F2	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342381
RPL32	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
HBZ	Pathway Commons Protein-Protein Interactions	1.0	null
Hemoglobin F Disease	DisGeNET Gene-Disease Associations	1.0	null
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0900141
RAVER1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38172
Transthyretin amyloidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
K562_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161864
8769_ELOB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542468
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
activating	GeneRIF Biological Term Annotations	1.0	null
7157_RBM14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.600093
SIX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91708
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0810084
DDOST	Pathway Commons Protein-Protein Interactions	1.0	null
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241527
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205904
cholesterol	GeneRIF Biological Term Annotations	1.0	null
gammaglobin	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4291	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.3438
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138753
9215_TPR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.874879
dred	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98598
6188_PDLIM4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657113
K562_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0451569
Synovial Sarcoma	DisGeNET Gene-Disease Associations	1.0	null
Human - Fetal Development - L1 - Erythroblasts	HuBMAP Azimuth Cell Type Annotations	1.0	null
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563753
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0467126
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0500025
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
NUP214	Pathway Commons Protein-Protein Interactions	1.0	null
PUM1	Pathway Commons Protein-Protein Interactions	1.0	null
gastroenteritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	2.39332
Metabolism of lipids	Reactome Pathways 2024	1.0	null
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320955
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0393558
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0329843
adult	GeneRIF Biological Term Annotations	1.0	null
K562_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.144724
HBG2	Pathway Commons Protein-Protein Interactions	1.0	null
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5969
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Puberty, Precocious	CTD Gene-Disease Associations	1.0	1.1753
sodium	GeneRIF Biological Term Annotations	1.0	null
abnormality of the spleen	HPO Gene-Disease Associations	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902466
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949852
K562_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369532
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2215
Sickle Cell Trait	DisGeNET Gene-Disease Associations	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
4166_IPO9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595954
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08876
HK2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255761
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTF2B	Pathway Commons Protein-Protein Interactions	1.0	null
spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.696989
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961289
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ccaat	GeneRIF Biological Term Annotations	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56354
once	GeneRIF Biological Term Annotations	1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48556
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10498
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0500422
segregation	GeneRIF Biological Term Annotations	1.0	null
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF728	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44209
IEC-18 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994027
Atrophy	CTD Gene-Disease Associations	1.0	1.39338
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900026
PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q734-0226-SM-48U1A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884409
GSTP1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS15A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Intestinal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4241
5302_MTBP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.957479
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0337005
PFKL	Pathway Commons Protein-Protein Interactions	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.706
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03966
Jejunum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.383
Non-Infiltrating Lobular Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90132
Polycythemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
Malaria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
4901_MCM4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.892648
K562_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0502878
generalized abnormality of skin	HPO Gene-Disease Associations	1.0	null
PIMREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78559
disrupting	GeneRIF Biological Term Annotations	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.035304
RWDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11247
ASF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03153
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9802_WDHD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582605
K562_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268844
PSMD11	Pathway Commons Protein-Protein Interactions	1.0	null
2427_DYNLL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675342
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0815981
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3183
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14447
AP2A1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0434558
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053589
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
splenomegaly	HPO Gene-Disease Associations	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7559_RRN3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505249
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0395119
K562_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0329272
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTLL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82989
PSMA1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256292
Blood cell_Pancreas_Human	CellMarker Gene-Cell Type Associations	1.0	null
PMC9556862__F1	PFOCR Pathway Figure Associations 2024	1.0	null
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307419
VTA1	Pathway Commons Protein-Protein Interactions	1.0	null
PI4KA	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0350754
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3325
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0412147
apicidin	GeneRIF Biological Term Annotations	1.0	null
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0698619
HLF	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.39822
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.510495
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
indirectly	GeneRIF Biological Term Annotations	1.0	null
YTHDF2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0821845
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.476589
Enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
BLVRB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
inducing	GeneRIF Biological Term Annotations	1.0	null
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0386516
SMARCA4	Pathway Commons Protein-Protein Interactions	1.0	null
beta thalassemia	GWASdb SNP-Disease Associations	1.0	1.94201
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1426
CRCGN014_HEPG2_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62119
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2854-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.845902
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2861
NUP205	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0619782
SLIK (SAGA-like) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
PMC4490691-13045_2015_154_MOESM1_ESM.docx-0-FKHRL1_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TCERG1	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
bcl11a	GeneRIF Biological Term Annotations	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09609
Crfk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.05
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00607
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08568
K562_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330509
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862261
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960891
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.73485
K562_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0540666
higher	GeneRIF Biological Term Annotations	1.0	null
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027025
Duodenum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.432
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
ESYT1	Pathway Commons Protein-Protein Interactions	1.0	null
GLRX3	Pathway Commons Protein-Protein Interactions	1.0	null
5127_MMS22L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.31036
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17262
6215_PELP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.65919
PPP1R15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39962
CCAAT-binding factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.522
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925842
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21276
4903_MCM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07873
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.935729
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37722
Hypochromic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.798
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0389748
VDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224482
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0870375
CAPRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
LS513	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.18511
2087_DDB1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507323
MRPL19	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0345633
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.163205
reporter	GeneRIF Biological Term Annotations	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.035401
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
affinity	GeneRIF Biological Term Annotations	1.0	null
ARPC3	Pathway Commons Protein-Protein Interactions	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42254
EPN1	Pathway Commons Protein-Protein Interactions	1.0	null
2269_DNA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.644246
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.371994
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
K562_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.036607
progenitor	GeneRIF Biological Term Annotations	1.0	null
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
Sickle cell disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.085
FOXD4L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53311
cell division site part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.103455
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00279
wdr5	GeneRIF Biological Term Annotations	1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56404
8933_TIPIN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515026
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
regulation of body fluid levels	GO Biological Process Annotations 2015	1.0	null
placenta_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.70119
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917078
Infertility, Male	CTD Gene-Disease Associations	1.0	1.36019
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0805914
pallor	HPO Gene-Disease Associations	1.0	null
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166112
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848425
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.910889
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29806
positive regulation of cell death	GO Biological Process Annotations 2023	1.0	null
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291878
number	GeneRIF Biological Term Annotations	1.0	null
nurd	GeneRIF Biological Term Annotations	1.0	null
dynamic	GeneRIF Biological Term Annotations	1.0	null
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0517402
HSPE1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
15297395-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
INPPL1	Pathway Commons Protein-Protein Interactions	1.0	null
4488_L2HGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745102
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49408
agammaglobin	GeneRIF Biological Term Annotations	1.0	null
MYO18A	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
fog1	GeneRIF Biological Term Annotations	1.0	null
region	GeneRIF Biological Term Annotations	1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6408-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.904931
concomitant	GeneRIF Biological Term Annotations	1.0	null
K562_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.100354
2828_RAMAC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519278
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77943
JHH5	CCLE Cell Line Gene CNV Profiles	1.0	1.55146
COA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27302
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.064463
Adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.406
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
K562_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190436
lead	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intestinal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.545739
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
Pharyngeal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.85
16513838-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68488
COLO201	CCLE Cell Line Gene CNV Profiles	1.0	1.58366
ARID3A	ENCODE Transcription Factor Targets	1.0	null
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.654772
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13484
PRMT5	Pathway Commons Protein-Protein Interactions	1.0	null
ITGB1	Pathway Commons Protein-Protein Interactions	1.0	null
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03985
gas transport	GO Biological Process Annotations 2025	1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.322
autosomal dominant inheritance	HPO Gene-Disease Associations	1.0	null
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06187
K562_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214932
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64976
GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCMT1	Pathway Commons Protein-Protein Interactions	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22566
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0407194
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0465184
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
brain cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253191
DLGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43227
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22566
REST_Panc1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTC1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79504
TYMS	Pathway Commons Protein-Protein Interactions	1.0	null
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303241
PMC5819186-13040_2018_163_MOESM3_ESM.xlsx-Lung-TCF21_TCF21	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7338-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
UBE2N	Pathway Commons Protein-Protein Interactions	1.0	null
GB1_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.00864
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.257652
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0218
ZBTB49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58739
promoters	GeneRIF Biological Term Annotations	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33301
PMC11049885__F3	PFOCR Pathway Figure Associations 2024	1.0	null
DNM2	Pathway Commons Protein-Protein Interactions	1.0	null
ALDOA	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0364982
POLR2A	ENCODE Transcription Factor Targets	1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.79371
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.87155
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06698
gut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094162
S100A7	Pathway Commons Protein-Protein Interactions	1.0	null
viral capsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.23088
GALK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31622
noncoding	GeneRIF Biological Term Annotations	1.0	null
thal	GeneRIF Biological Term Annotations	1.0	null
4333_KEAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513536
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06518
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DHRS4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3019
regulated	GeneRIF Biological Term Annotations	1.0	null
lymph node	HPA Tissue Gene Expression Profiles	-1.0	-0.835247
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
low	GeneRIF Biological Term Annotations	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05633
6748_PRIM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75597
thalassemia	GWASdb SNP-Disease Associations	1.0	1.94201
bone marrow	HPA Tissue Protein Expression Profiles	1.0	0.864208
CRKL	Pathway Commons Protein-Protein Interactions	1.0	null
beta-thalassemia	GAD Gene-Disease Associations	1.0	null
SDCBP	Pathway Commons Protein-Protein Interactions	1.0	null
8718_TBC1D31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.603905
developmental	GeneRIF Biological Term Annotations	1.0	null
GSE218060_1_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
RPA1	Pathway Commons Protein-Protein Interactions	1.0	null
provide	GeneRIF Biological Term Annotations	1.0	null
K562_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163653
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
K562_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204646
PHYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72682
THOC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25613
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189782
months	GeneRIF Biological Term Annotations	1.0	null
18811983-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2533
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.36899
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.173355
haplotype	GeneRIF Biological Term Annotations	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16086
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.845902
CRCGN012_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33611
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.447656
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
model	GeneRIF Biological Term Annotations	1.0	null
K562_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0358729
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.135976
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of cellular process	GO Biological Process Annotations 2023	1.0	null
Red blood cell (erythrocyte)_Bone marrow_Human	CellMarker Gene-Cell Type Associations	1.0	null
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959409
RUNX1_01_245	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.68116
Gut cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05487
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02617
ARF5	Pathway Commons Protein-Protein Interactions	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40868
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
K562_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0742493
oxygen transport	GO Biological Process Annotations 2015	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.947019
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
Hemostasis	Reactome Pathways 2014	1.0	null
K562_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.133363
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.941273
chromosome, telomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.007
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.88342
Paralytic poliomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
S100A8	Pathway Commons Protein-Protein Interactions	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18109
inhibitor	GeneRIF Biological Term Annotations	1.0	null
THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.2661
Extracellular ferritin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.897
CHP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45852
KDM1A	ENCODE Transcription Factor Targets	1.0	null
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
LN235	Achilles Cell Line Gene Essentiality Profiles	1.0	1.36082
Factors involved in megakaryocyte development and platelet production	Reactome Pathways 2014	1.0	null
unrelated	GeneRIF Biological Term Annotations	1.0	null
klf1	GeneRIF Biological Term Annotations	1.0	null
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.918183
AKR7A2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0545879
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.578281
PMC7450072-41598_2020_71096_MOESM1_ESM.xlsx-Table1_SS_vs_AA_RBC_lys-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06744
3635_HAUS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535155
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
Lung adenocarcinoma_LUAD_TCGA-73-4676-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02617
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7801
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0550815
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69367
K562_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019449
MOTN1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32275
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
agamma	GeneRIF Biological Term Annotations	1.0	null
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166212
CRCGN009_HEPG2_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03021
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25109
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159935
affect	GeneRIF Biological Term Annotations	1.0	null
Rovs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0323335
2336_DONSON_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.812351
salivary gland	GTEx Tissue Gene Expression Profiles	-1.0	-1.55327
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
4946_MED23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512041
spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.064688
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16771
5205_MRPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.576687
7648_SAP18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564485
SLC8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5781
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09703
OAW42	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18835
PPIH	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57289
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.961465
proximal	GeneRIF Biological Term Annotations	1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
hescsderived	GeneRIF Biological Term Annotations	1.0	null
FLOT1	Pathway Commons Protein-Protein Interactions	1.0	null
2727_ESCO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526942
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
7891_SHC1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564604
15902281-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
contribute	GeneRIF Biological Term Annotations	1.0	null
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187617
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0282988
GNB1L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131649_4_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
K562_Iniparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0370825
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.08833
GTEX-RTLS-0926-SM-2TF5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921485
abnormality of blood and blood-forming tissues	HPO Gene-Disease Associations	1.0	null
graft-versus-host disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
RK-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
LB2518-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44549
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0343989
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06187
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12756
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43527
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043883
gm95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.062863
microcytic anemia	HPO Gene-Disease Associations	1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4241
3369_GINS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.603006
erythroblasts	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854687
9324_TRPM7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619874
Tou	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.136
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042039
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02545
salivary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139432
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98613
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Erythroblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45206
SOX2-16153702-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
recruits	GeneRIF Biological Term Annotations	1.0	null
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
HCC56	CCLE Cell Line Gene CNV Profiles	1.0	1.61744
GNB1	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93149
NCIH1944_LUNG	CCLE Cell Line Proteomics	1.0	2.25661
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0900573
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18406
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0317219
encoding	GeneRIF Biological Term Annotations	1.0	null
ontogeneticspecific	GeneRIF Biological Term Annotations	1.0	null
UBE2M	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5082879__F2	PFOCR Pathway Figure Associations 2023	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114921
iron ion binding	GO Molecular Function Annotations 2015	1.0	null
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0537229
cofactor	GeneRIF Biological Term Annotations	1.0	null
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43621
Globin, structural domain	InterPro Predicted Protein Domain Annotations	1.0	null
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277287
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PES1	Pathway Commons Protein-Protein Interactions	1.0	null
Gastroenteritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.236
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02637
modulation	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07511
6923_PTPN11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.840295
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056515
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0902525
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994027
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1682
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
PFDN2	Pathway Commons Protein-Protein Interactions	1.0	null
TBC1D15	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0891378
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LMNB1	Pathway Commons Protein-Protein Interactions	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065986
1560_CHD4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.80592
GSE183327,GSE183328_3_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fetal Hemoglobin Quantitative Trait	DisGeNET Gene-Phenotype Associations	1.0	null
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0488476
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
COG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95034
AP2S1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-922	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
K562_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181586
Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07409
gamma	GeneRIF Biological Term Annotations	1.0	null
abnormality of the heme biosynthetic pathway	HPO Gene-Disease Associations	1.0	null
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01236
K562_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0693991
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	3.07781
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163138
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Premonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0717809
there	GeneRIF Biological Term Annotations	1.0	null
6154_PDCD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.511256
D283MED	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77746
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
9174_TOP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.749669
CAPAN2	CCLE Cell Line Gene CNV Profiles	1.0	1.58157
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09937
USP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57371
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.689
TEDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4344
K562_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194443
Acute Myeloid Leukemia_LAML_TCGA-AB-2890-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
creb1	GeneRIF Biological Term Annotations	1.0	null
CRCGN010_HEPG2_24H:N24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02379
9328_TRRAP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35175
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0400945
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583386
K562_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0822721
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.983107
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.24465
treated	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6742-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8866
NCIH2227	CCLE Cell Line Gene CNV Profiles	1.0	1.79069
3134_FOLR3_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622706
Porphyria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
261_ALDOA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564828
autosomal recessive disease	GWASdb SNP-Disease Associations	1.0	1.68221
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0388286
K562_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0458897
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
3722_HIC2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.32684
locus	GeneRIF Biological Term Annotations	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.37505
TTLL12	Pathway Commons Protein-Protein Interactions	1.0	null
IGROV1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.53794
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844245
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75503
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.540878
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180468_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
rna	GeneRIF Biological Term Annotations	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76719
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.291
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12073
TEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70206
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.051242
PMC5647233__F4	PFOCR Pathway Figure Associations 2023	1.0	null
K562_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0455334
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23458
K562_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0525342
oct1	GeneRIF Biological Term Annotations	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64428
Haemoglobin, beta	InterPro Predicted Protein Domain Annotations	1.0	null
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062768
MPV17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51393
ACER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17821
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525019
mediate	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.35527
K562_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0404243
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.049564
4926_MEAF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.282
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994027
CRCGN017_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44647
2297_DNAJC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607748
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73735
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915008
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00201
FKBP4	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1255
K562_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173727
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57812
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22978
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9966
Chorionic villus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
K562_YM155_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165701
AARS	Pathway Commons Protein-Protein Interactions	1.0	null
silenced	GeneRIF Biological Term Annotations	1.0	null
ZNF629	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4542
thalassemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.06123
VCP	Pathway Commons Protein-Protein Interactions	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NE-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0686586
hematological	GAD High Level Gene-Disease Associations	1.0	0.295739
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.11015
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
NQO1	Pathway Commons Protein-Protein Interactions	1.0	null
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828149
cell cortex part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059441
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.906493
6288_PHF23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55557
HEATR1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0400923
5583_NEDD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.668626
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52339
8904_TICRR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.681935
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
coculture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.272649
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
19305503-TableS1	GeneSigDB Published Gene Signatures	1.0	null
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0333806
daily	GeneRIF Biological Term Annotations	1.0	null
cytosolic part	GO Cellular Component Annotations 2015	1.0	null
7407_RNPS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515584
K562_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.026897
Erythroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.277
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89653
Interstitial cell of Cajal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.033501
HIST1H2BL	Pathway Commons Protein-Protein Interactions	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21119
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510661
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.07
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0497342
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.658582
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU5F1-16153702-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0331904
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04776
SART3	Pathway Commons Protein-Protein Interactions	1.0	null
PSMB2	Pathway Commons Protein-Protein Interactions	1.0	null
Blood protein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.977
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	1.0	3.58108
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39718
TRAPPC3	Pathway Commons Protein-Protein Interactions	1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0368133
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223662
TE14_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	3.84143
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0590747
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55921
clustered	GeneRIF Biological Term Annotations	1.0	null
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141962
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14136
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B3-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18172295-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
placenta_3a	HPA Tissue Sample Gene Expression Profiles	1.0	2.32927
SF1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0442299
GTEX-XPVG-0626-SM-4B65B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831837
HIP1	Pathway Commons Protein-Protein Interactions	1.0	null
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
differentiating	GeneRIF Biological Term Annotations	1.0	null
k562clones	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.311
transactivators	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09275
K562_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288642
NuRD complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.754
Congenital dyserythropoietic anemia type IV	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
4899_MCM3AP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.74941
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63496
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.864208
biological_process	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7062-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.403637
GSE76425_1_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.133
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69251
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0944996
PSMA7	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9766_VPS72_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.57798
PSMB6	Pathway Commons Protein-Protein Interactions	1.0	null
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274788
PDCD6IP	Pathway Commons Protein-Protein Interactions	1.0	null
interactions	GeneRIF Biological Term Annotations	1.0	null
Disease by infectious agent	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.748
H3K36me3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26935
Hereditary spherocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
308_ANAPC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595681
Human - Fetal Development - L1 - STC2_TLX1 positive cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
Hemostasis	Reactome Pathways 2024	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528321
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16264
ACSM3	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.924776
7734_SEC13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.822151
alpha-thalassemia myelodysplasia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
absence	GeneRIF Biological Term Annotations	1.0	null
hemoglobin complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
RPL13A	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0368744
6486_PNISR_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510088
4139_INPPL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.88146
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29887
K562_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0596679
K562_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275289
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63496
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
involvement	GeneRIF Biological Term Annotations	1.0	null
regions	GeneRIF Biological Term Annotations	1.0	null
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16459
PSMB1	Pathway Commons Protein-Protein Interactions	1.0	null
recruitment	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83T-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
work	GeneRIF Biological Term Annotations	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31928
1841_INTS11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619958
mapk	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4795-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
SRI	Pathway Commons Protein-Protein Interactions	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.57234
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04625
K562_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.07628
abnormality of the integument	HPO Gene-Disease Associations	1.0	null
GRB2	Pathway Commons Protein-Protein Interactions	1.0	null
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1972
K562_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0671073
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32123
Prostate adenocarcinoma_PRAD_TCGA-VN-A88N-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124803
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825561
Buccal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	6.24357
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0393291
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.22404
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3071
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.10838
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
6123_PCGF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650502
visceromegaly	HPO Gene-Disease Associations	1.0	null
Liver	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
COASY	Pathway Commons Protein-Protein Interactions	1.0	null
83_ACIN1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563565
CBX3	ENCODE Transcription Factor Targets	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.842449
K-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.155
4871_MAX_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	4.39237
AP2B1	Pathway Commons Protein-Protein Interactions	1.0	null
534_ARPC1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.980392
binding	GO Molecular Function Annotations 2015	1.0	null
CACO-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.73118
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0813987
HCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81204
Iron-Refractory Iron Deficiency Anemia	DisGeNET Gene-Disease Associations	1.0	null
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33301
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
GTEX-OOBK-2025-SM-3LK5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01
k562	GeneRIF Biological Term Annotations	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7672319-mmc3.xlsx-Senescence_MSigDB62-TANG_SENESCENCE_TP53_inhibition__TARGETS_UP_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.191
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.1204
PDCD6	Pathway Commons Protein-Protein Interactions	1.0	null
Gamma Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.851934
transport	GO Biological Process Annotations 2015	1.0	null
HMGA1	Pathway Commons Protein-Protein Interactions	1.0	null
325_ANKRD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535503
hemoglobin alpha binding	GO Molecular Function Annotations 2025	1.0	null
skin	HPA Tissue Gene Expression Profiles	-1.0	-1.78129
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.16401
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051425
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81501
point	GeneRIF Biological Term Annotations	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067186
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42043
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
UACC893	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00797
cmyb	GeneRIF Biological Term Annotations	1.0	null
CTSH	Pathway Commons Protein-Protein Interactions	1.0	null
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0963993
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
transgenic	GeneRIF Biological Term Annotations	1.0	null
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.030153
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
HIST3H3	Pathway Commons Protein-Protein Interactions	1.0	null
YARS	Pathway Commons Protein-Protein Interactions	1.0	null
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631334
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57782
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.10562
Beta Thalassemia Trait	DisGeNET Gene-Disease Associations	1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vorinostat_homo sapiens_gpl6884_gse46703	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
detroit551	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMEL28	CCLE Cell Line Gene CNV Profiles	1.0	1.32981
MAPRE1	Pathway Commons Protein-Protein Interactions	1.0	null
ABCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39236
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
Brain cortex cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064953
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
urinary bladder	HPA Tissue Gene Expression Profiles	-1.0	-0.835247
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4926
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94696
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867762
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04553
hsa-miR-4327	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CNOT1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Megakaryocytic Leukemias	DisGeNET Gene-Disease Associations	1.0	null
K562_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0766427
K562_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0946154
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89891
mice	GeneRIF Biological Term Annotations	1.0	null
intermedia	GeneRIF Biological Term Annotations	1.0	null
LRF	MotifMap Predicted Transcription Factor Targets	1.0	null
JURLMK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45375
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
complexes	GeneRIF Biological Term Annotations	1.0	null
exert	GeneRIF Biological Term Annotations	1.0	null
MCM4	Pathway Commons Protein-Protein Interactions	1.0	null
bindings	GeneRIF Biological Term Annotations	1.0	null
19893615-Table3	GeneSigDB Published Gene Signatures	1.0	null
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.9341
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0409359
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2339_DPCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.802305
EIF2S1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886382
ggamma	GeneRIF Biological Term Annotations	1.0	null
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293003
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EK-01A-22R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mode of inheritance	HPO Gene-Disease Associations	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55803
dyskeratosis congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.610057
K562_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.131766
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
K562_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0450921
K562_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174705
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5652
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PHACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47187
PRKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28497
intergenic	GeneRIF Biological Term Annotations	1.0	null
IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.897
1287_CCDC69_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.542272
K562_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0546093
Human - Fetal Development - L2 - Spleen-STC2_TLX1 positive cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.25018
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Malaria	DisGeNET Gene-Disease Associations	1.0	null
1831_CPNE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.1578
Brain Lower Grade Glioma_LGG_TCGA-HT-7478-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUP155	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0359971
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
1706_CNDP2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.666097
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19987
Red blood cell (erythrocyte)_Placenta_Human	CellMarker Gene-Cell Type Associations	1.0	null
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0453397
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
fetus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.0582
K562_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0645489
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.00928
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
heme binding	GO Molecular Function Annotations 2015	1.0	null
K562_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0796752
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blocks	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42853
TAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18317
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971246
erythroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224993
Chronic myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.158
OVCAR8_OVARY	CCLE Cell Line Proteomics	1.0	3.08533
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0551564
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.855677
Neonate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.763
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.903477
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50585
ABCE1	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abnormal Bone Structure	DisGeNET Gene-Disease Associations	1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	1.0	1.61526
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.127935
fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094712
CRCGN017_MCF10A.WT.HP_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00967
6135_PCNA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504562
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2547
MEL-745A cl. DS19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.429
VCL	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17387
betathalassemia	GeneRIF Biological Term Annotations	1.0	null
isoforms	GeneRIF Biological Term Annotations	1.0	null
connection	GeneRIF Biological Term Annotations	1.0	null
Congenital hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.975
Human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
KPNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34635
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0941
NCIH1355	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81701
K562_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267381
DDX42	Pathway Commons Protein-Protein Interactions	1.0	null
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.059
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the skin	HPO Gene-Disease Associations	1.0	null
1919_CS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534446
Necrosis	CTD Gene-Disease Associations	1.0	1.59661
6667_PPP1R2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515655
K562_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.217029
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7299
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172972
K562_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246683
posttranscriptional	GeneRIF Biological Term Annotations	1.0	null
Severe Beta Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
Delta beta-thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.846
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
tr2tr4	GeneRIF Biological Term Annotations	1.0	null
7898_SHOC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622204
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
ca96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.064
K562_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0335998
ZNF534	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77624
968_C12ORF60_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.997375
TCEAL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55393
GP1BB	Pathway Commons Protein-Protein Interactions	1.0	null
Erythroleukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.291
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27669
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00076
10574_ZNF706_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.6878
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
modeling	GeneRIF Biological Term Annotations	1.0	null
8904_TICRR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.851436
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052804
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962632
GTEX-R45C-1226-SM-48FEE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854692
236_AKIRIN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619489
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82953
K562_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.053011
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17248
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
element	GeneRIF Biological Term Annotations	1.0	null
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44617
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.757755
PDCD10	Pathway Commons Protein-Protein Interactions	1.0	null
Severe combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10728
Blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
CRCGN009_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24665
fetal cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.25112
ITSN2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65S-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10728
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.825
HIST1H2BJ	Pathway Commons Protein-Protein Interactions	1.0	null
lower	GeneRIF Biological Term Annotations	1.0	null
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0358319
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041524
K562_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209232
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
1296_CCDC78_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584625
DECR1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL10	Pathway Commons Protein-Protein Interactions	1.0	null
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
SMCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
specificity	GeneRIF Biological Term Annotations	1.0	null
RNASE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59858
containing	GeneRIF Biological Term Annotations	1.0	null
ZFYVE27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62777
Rectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
Alpha^+^ Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	2.31415
K562_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0567643
RHBDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89598
SIRT6	ENCODE Transcription Factor Targets	1.0	null
Pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.407919
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016244
5970_ORC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510639
hutu80	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.877
GSE228106_3_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU5F1-16153702-HESC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Hyperuricemia	DisGeNET Gene-Disease Associations	1.0	null
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02739
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02617
MAPKAPK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26128
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0677731
MONOMAC6	Achilles Cell Line Gene Essentiality Profiles	1.0	1.45689
glimpse	GeneRIF Biological Term Annotations	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0851771
KCNIP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07312
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0508636
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta thalassemia/hemoglobin e disease	GAD Gene-Disease Associations	1.0	null
2496_EFHD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.654684
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.02085
hydrogen peroxide catabolic process	GO Biological Process Annotations 2025	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.89485
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02823
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96737
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252318
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
REEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93881
K562_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.122609
TRAF3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79478
K562_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322593
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
process	GeneRIF Biological Term Annotations	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PPID	Pathway Commons Protein-Protein Interactions	1.0	null
hydrogen peroxide catabolic process	GO Biological Process Annotations 2023	1.0	null
Subrhabdomeral cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.555
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0523243
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298421
CRCGN015_MCF10A.TP53.M_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85163
IGHG1	Pathway Commons Protein-Protein Interactions	1.0	null
Hemoglobin H disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
PSMA5	Pathway Commons Protein-Protein Interactions	1.0	null
812_BCR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.87432
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836984
Olfactory placode cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.821
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
involving	GeneRIF Biological Term Annotations	1.0	null
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71503
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330785
hsa-miR-362-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08746
regulation of cell death	GO Biological Process Annotations 2023	1.0	null
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
1152_CAD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35973
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0468974
Small intestine mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Sicca Syndrome	DisGeNET Gene-Disease Associations	1.0	null
abnormal hemoglobin	HPO Gene-Disease Associations	1.0	null
butyrate	GeneRIF Biological Term Annotations	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
CTCF-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Beta Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
PNP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	8.53979
NCIH1915	CCLE Cell Line Gene CNV Profiles	1.0	2.07788
observations	GeneRIF Biological Term Annotations	1.0	null
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
KS1	CCLE Cell Line Gene CNV Profiles	1.0	2.93347
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241843
protein-carbohydrate complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.446465
3755_HIST1H2AK_ENST00000330180.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55291
xmni	GeneRIF Biological Term Annotations	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.547
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.461078
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34528
RPL26	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58192
PITX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66928
abnormality of the lymphatic system	HPO Gene-Disease Associations	1.0	null
ITGA4	Pathway Commons Protein-Protein Interactions	1.0	null
10016_ZBTB9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.709037
elevation	GeneRIF Biological Term Annotations	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05226
acetylated	GeneRIF Biological Term Annotations	1.0	null
unique	GeneRIF Biological Term Annotations	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
4686_LSM11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589605
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.55389
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38652
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91512
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0048
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
establish	GeneRIF Biological Term Annotations	1.0	null
X-linked thrombocytopenia with beta-thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
GSE131649_2_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884059
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45691
237_AKIRIN2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.724225
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256734
7252_RFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.837832
multiprotein	GeneRIF Biological Term Annotations	1.0	null
control	GeneRIF Biological Term Annotations	1.0	null
mediates	GeneRIF Biological Term Annotations	1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
adults	GeneRIF Biological Term Annotations	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11643
hep-g2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25858
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
PLCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27922
Gut mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
6842_PSMA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569245
abnormality of erythrocytes	GWASdb SNP-Phenotype Associations	1.0	0.49797
MEL-JUSO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903648
repressing	GeneRIF Biological Term Annotations	1.0	null
solid	GeneRIF Biological Term Annotations	1.0	null
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284078
ACTR2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0458918
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
Buffy coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.411
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065904
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.717433
aminophospholipids	GeneRIF Biological Term Annotations	1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33565
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
markers	GeneRIF Biological Term Annotations	1.0	null
K562_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0578388
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153324
SRP9	Pathway Commons Protein-Protein Interactions	1.0	null
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
7717_ENTR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.21037
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.845902
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.065568
K562_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0360286
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.465335
upstream	GeneRIF Biological Term Annotations	1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.8108
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8467
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Synthesis of very long-chain fatty acyl-CoAs	Reactome Pathways 2024	1.0	null
TMEM120A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11062
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.761797
4897_MCM10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21101
K562_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0489593
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897897
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.691
K562_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197494
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0519
HPFH(-198) complex	CORUM Protein Complexes	1.0	null
one-carbon compound transport	GO Biological Process Annotations 2025	1.0	null
8733_TBKBP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.669659
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
LGALS1	Pathway Commons Protein-Protein Interactions	1.0	null
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.03419
heme binding	GO Molecular Function Annotations 2023	1.0	null
K562_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325845
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-2.35137
ZC3H7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4411
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076308
5587_NEDD8-MDP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.750258
blood coagulation	GO Biological Process Annotations 2015	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
K562_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0377198
EMD	Pathway Commons Protein-Protein Interactions	1.0	null
GOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25211
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873887
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANXA1	Pathway Commons Protein-Protein Interactions	1.0	null
inhibition	GeneRIF Biological Term Annotations	1.0	null
HBG1 POLYMORPH	ClinVar Gene-Phenotype Associations 2025	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEPT7	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0600405
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.165598
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175846
immediately	GeneRIF Biological Term Annotations	1.0	null
CLTA	Pathway Commons Protein-Protein Interactions	1.0	null
second	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A520-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Persistence Of Hemoglobin F	DisGeNET Gene-Phenotype Associations	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886713
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16008
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8401_SREBF1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57195
retrotransposon nucleocapsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.69399
Thalassemia minor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.944
actomyosin contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.183935
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16362
K562_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307711
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0430105
PYCR2	Pathway Commons Protein-Protein Interactions	1.0	null
Hereditary Persistence Of Fetal Hemoglobin Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
heterozygotes	GeneRIF Biological Term Annotations	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971517
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Human - Fetal Development - L2 - Heart-Smooth muscle cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953221
assoicated	GeneRIF Biological Term Annotations	1.0	null
K562_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0416706
K562_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.101068
mucous cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180438
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7162
9587_UMPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.759235
19377508-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
evidence	GeneRIF Biological Term Annotations	1.0	null
DENND4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57904
ARAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Hereditary Gingival Fibromatosis	DisGeNET Gene-Disease Associations	1.0	null
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0660152
K562_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0352734
K562_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325775
K562_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338676
hbf	GeneRIF Biological Term Annotations	1.0	null
5969_ORC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.34829
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896103
K562_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0314168
K562_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0870018
3667_HDAC7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02286
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24341
methemoglobinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.544705
autosomal genetic disease	GWASdb SNP-Disease Associations	1.0	1.17223
ETF1	Pathway Commons Protein-Protein Interactions	1.0	null
Gastrointestinal endocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.205
Hemoglobinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.034
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
PSME3	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29328
Umbilical cord blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.825
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1745
ERLIN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11342215-mmc2.xlsx-Protein_list-Table_S1_Protein_information_of_LC-MS_MS_data_from_one_analysis_between_FXN_KD_and_Ctrl_of_Ovcar5_spheroids_related_to_Figure_4_and_STAR_methods_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.789435
PTPN11	Pathway Commons Protein-Protein Interactions	1.0	null
RPL10A	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339308
1323_CCND3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66413
CLIC1	Pathway Commons Protein-Protein Interactions	1.0	null
Erythroleukemia (Erythroid/Myeloid)	DisGeNET Gene-Disease Associations	1.0	null
CUX1	ChEA Transcription Factor Targets	1.0	null
PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
mucous gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.135477
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63307
K562_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131733
PIN1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0683715
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546152
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75734
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORO1C	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09232
PSMD12	Pathway Commons Protein-Protein Interactions	1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055794
depending	GeneRIF Biological Term Annotations	1.0	null
PMC2813300-pone.0008960.s011.xls-SOX2_targets_in_human_ESCs-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
POMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39897
inner CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15581
HIST1H1E	Pathway Commons Protein-Protein Interactions	1.0	null
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.23363
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
2807_F11R_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745404
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.05089
PPP1CB	Pathway Commons Protein-Protein Interactions	1.0	null
17312329-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
SEPT11	Pathway Commons Protein-Protein Interactions	1.0	null
G3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
Platelet SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
Anemia	DisGeNET Gene-Disease Associations	1.0	null
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32068
LSM3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256614
TCF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81716
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
6515_POLD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02983
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22425
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
A-Netherlands-602-2009(H1N1)_7Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.71935
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Chorion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.177
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950434
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.143
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021291
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046031
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
7246_RFC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712249
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257828
cuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00891
GTEX-VJYA-1326-SM-3GIJC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08041
PMC11049885__F2	PFOCR Pathway Figure Associations 2024	1.0	null
KRT6A	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259621
K562_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0659245
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.24518
PANC1005	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.31576
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17371
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.29589
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
forms	GeneRIF Biological Term Annotations	1.0	null
K562_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180152
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270677
6515_POLD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.757168
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0792879
6912_PTGR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.684084
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882809
organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PLB985	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01988
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0461076
DNMT1	Pathway Commons Protein-Protein Interactions	1.0	null
2990_FBRS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550959
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MPF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.649
UBE2NL	Pathway Commons Protein-Protein Interactions	1.0	null
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
SNU685_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.11802
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.56198
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11353
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25709
chronic myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.162026
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4898_MCM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.979314
17178874-Table1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986199
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54459
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.957509
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
HIST1H1B	Pathway Commons Protein-Protein Interactions	1.0	null
EMSY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53081
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0717564
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884404
PSMD3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155943
6516_POLD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560465
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04099
GANAB	Pathway Commons Protein-Protein Interactions	1.0	null
BJAB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
U118MG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.29693
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76284
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961769
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.03564
Combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
SRSF6	Pathway Commons Protein-Protein Interactions	1.0	null
7950_SLBP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0826
case	GeneRIF Biological Term Annotations	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14869
H1-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71125
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17794
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0844625
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49408
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.705
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
inner CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18352
451_ARFIP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.725628
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06187
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16217
Thoracic thymus_CT1_erythroid	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
K562_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0319084
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
5580_NECAB3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.735658
K562_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298146
Buffy coat cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
NDUFS1	Pathway Commons Protein-Protein Interactions	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325316
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79165
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14059
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07653
K562_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188218
K562_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203422
CAPNS1	Pathway Commons Protein-Protein Interactions	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.08619
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
K562_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242471
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
together	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92065
C8orf82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35718
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03952
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8138
outer CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842498
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
Mantle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
RMGI	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.83469
integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045493
K562_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01505
NUDC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968266
genetic disease	GWASdb SNP-Disease Associations	1.0	0.793714
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.382223
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36536
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
Cord blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.995
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51736
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955027
Juvenile Myelomonocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
5302_MTBP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.582088
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978105
EDC4	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.933
RAB5C	Pathway Commons Protein-Protein Interactions	1.0	null
10746_AC118549.1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549194
extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43633
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.505
Lymphoid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
TWIST1_01_254	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.18027
1560_CHD4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548253
APOE	Pathway Commons Protein-Protein Interactions	1.0	null
temporal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03681
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36137
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10786
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.748
active	GeneRIF Biological Term Annotations	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22566
neonate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31332
Beta^+^ Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
K562_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0682536
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0942
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03706
OLFML2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90726
reticulocytes	GeneRIF Biological Term Annotations	1.0	null
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0838698
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0284836
PMC7450072-41598_2020_71096_MOESM1_ESM.xlsx-Table3_SS_vs_AA_MP-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837188
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
longrange	GeneRIF Biological Term Annotations	1.0	null
BF-31-BY55_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280892
PRDX2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263805
K562_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.113607
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.322
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00738
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5622
oxygen transporter activity	GO Molecular Function Annotations 2015	1.0	null
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167107
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14059
8931_TINF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575731
oligonucleotide	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20P-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0674905
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0S7-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCRIB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12808636-41598_2025_31836_MOESM2_ESM.xlsx-S2-MR-BMI-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
1219_CBFA2T3_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.43885
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250255
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065817
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223882
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643488
VASP	Pathway Commons Protein-Protein Interactions	1.0	null
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83801
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882313
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0577223
DIAPH1	Pathway Commons Protein-Protein Interactions	1.0	null
LYPLA2	Pathway Commons Protein-Protein Interactions	1.0	null
UDP-N-acetylglucosamine transferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883481
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.33642
pkc	GeneRIF Biological Term Annotations	1.0	null
embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MAZ	ENCODE Transcription Factor Targets	1.0	null
GSE146982_0_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212348
MA-104 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.138
GSE107594_0_v_1_hmga2_human	RummaGEO Gene Perturbation Signatures	1.0	null
chronic myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.432608
Neonatal anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04201
MRPL43	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70I-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
clues	GeneRIF Biological Term Annotations	1.0	null
WDR36	Pathway Commons Protein-Protein Interactions	1.0	null
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07505
15843827-TableS6	GeneSigDB Published Gene Signatures	1.0	null
NSUN2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11681
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943995
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.100265
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUP210	Pathway Commons Protein-Protein Interactions	1.0	null
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104195
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241916
ANKHD1	Pathway Commons Protein-Protein Interactions	1.0	null
transacting	GeneRIF Biological Term Annotations	1.0	null
NAA38	Pathway Commons Protein-Protein Interactions	1.0	null
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12276197-18_2025_5784_MOESM1_ESM.xlsx-Sup_Table_10-Supplementary_Table_10_ERK_targets_from_Unal_et_al_2017_mapped_to_human_orthologous_genes_from_KD_and_SC_hypernetworks_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0704285
PROKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11978
k-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.456828
modulating	GeneRIF Biological Term Annotations	1.0	null
CCDC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11966
sb203580	GeneRIF Biological Term Annotations	1.0	null
Splenic sequestration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pleura	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193271
HBB	Pathway Commons Protein-Protein Interactions	1.0	null
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222938
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.044115
RANBP1	Pathway Commons Protein-Protein Interactions	1.0	null
critical	GeneRIF Biological Term Annotations	1.0	null
K562_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248969
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	2.48706
cellular_component	GO Cellular Component Annotations 2015	1.0	null
HBA2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0368308
dr1	GeneRIF Biological Term Annotations	1.0	null
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10X-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Actinobacillosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.606584
REST	ENCODE Transcription Factor Targets	1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13218
SLC38A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96081
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_25_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
directly	GeneRIF Biological Term Annotations	1.0	null
Hereditary persistence of fetal hemoglobin	ClinVar Gene-Phenotype Associations 2025	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BYSL	Pathway Commons Protein-Protein Interactions	1.0	null
Cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.625
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0496359
K562_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243908
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.043883
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204076
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	2.88009
Triple-Negative Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
9328_TRRAP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.623187
MRTO4	Pathway Commons Protein-Protein Interactions	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
YES1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225026
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50479
abnormality of the immune system	HPO Gene-Disease Associations	1.0	null
5933_OGT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22195
RPS5	Pathway Commons Protein-Protein Interactions	1.0	null
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.733673
TGOLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59612
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0804417
STAT5B	Pathway Commons Protein-Protein Interactions	1.0	null
Myeloid Leukemia	DisGeNET Gene-Disease Associations	1.0	null
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0864
stagespecific	GeneRIF Biological Term Annotations	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9616
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232733
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10202
ndhpfh	GeneRIF Biological Term Annotations	1.0	null
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298063
hbe	GeneRIF Biological Term Annotations	1.0	null
persistence of hemoglobin f	HPO Gene-Disease Associations	1.0	null
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0829875
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.665
4871_MAX_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.92621
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
berry	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.575616
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.42135
COPS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49322
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11886
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TWIST1_01_253	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.39391
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0498722
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.387
Mitotic spindle midzone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
Human - Fetal Development - L2 - Liver-Lymphoid cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
K562_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0424282
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.55301
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61732
Red blood cell (erythrocyte)_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28305
intracellular part	GO Cellular Component Annotations 2015	1.0	null
PSMD9	Pathway Commons Protein-Protein Interactions	1.0	null
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0414814
K562_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.205411
inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.401765
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of the abdominal organs	HPO Gene-Disease Associations	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17253
6127_PCID2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55344
stimulation	GeneRIF Biological Term Annotations	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
SOX2-16153702-HESC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
agammapromoterdriven	GeneRIF Biological Term Annotations	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
first	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02398
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
10339_ZNF414_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.13158
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.812309
bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
gallbladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.90408
496100646_TCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23584
CRCGN008_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09993
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36922
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0549651
shortchain	GeneRIF Biological Term Annotations	1.0	null
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19291
CRCGN008_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1243
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-AIRE-HIT_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
virion part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.0413
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0348659
EIF4H	Pathway Commons Protein-Protein Interactions	1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
CNBP	Pathway Commons Protein-Protein Interactions	1.0	null
nondeletional	GeneRIF Biological Term Annotations	1.0	null
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837965
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.713349
K562_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209686
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
Paneth cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
APRT	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-2326-SM-3GILF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847414
Abnormal Hemoglobin Finding	DisGeNET Gene-Phenotype Associations	1.0	null
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885261
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824993
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
Infertility, Female	CTD Gene-Disease Associations	1.0	1.17464
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374243
hydrogen peroxide metabolic process	GO Biological Process Annotations 2025	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.641
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38016
stability	GeneRIF Biological Term Annotations	1.0	null
204_AHCY_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808554
PMC10770899-13048_2023_1338_MOESM2_ESM.xlsx-All_gene_lists-TANG_SENESCENCE_TP53_TARGETS_UP_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
satb2	GeneRIF Biological Term Annotations	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15632
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
atf2	GeneRIF Biological Term Annotations	1.0	null
secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182695
Perturb_17635_KD_YTHDF2_SRP126652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.535
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
CAPN1	Pathway Commons Protein-Protein Interactions	1.0	null
7070_RAD51_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614844
Lung adenocarcinoma_LUAD_TCGA-50-6595-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113682
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096486
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.26547
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0578261
CHCHD3	Pathway Commons Protein-Protein Interactions	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23142
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CYCS	Pathway Commons Protein-Protein Interactions	1.0	null
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
HIP1R	Pathway Commons Protein-Protein Interactions	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
ZNF541	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39605
liver cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
4996_METTL18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547521
TP53	ChEA Transcription Factor Targets	1.0	null
respiratory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069049
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44154
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
Cardiac Arrest	DisGeNET Gene-Disease Associations	1.0	null
6760_PRKCA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534306
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.773934
RD-79-FH72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266152
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13086
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149144
MACROD1	Pathway Commons Protein-Protein Interactions	1.0	null
SW948_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.31415
PANC0203	CCLE Cell Line Gene CNV Profiles	1.0	2.00101
KRT8	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03223
all	HPO Gene-Disease Associations	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123249
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0362784
7648_SAP18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.7007
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.12964
GTEX-NPJ8-2526-SM-2HML8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954976
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
K562_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0481749
induction	GeneRIF Biological Term Annotations	1.0	null
Heme	HMDB Metabolites of Enzymes	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22979
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202431
PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
tetrapyrrole binding	GO Molecular Function Annotations 2015	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0567765
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.747
rb7	GeneRIF Biological Term Annotations	1.0	null
fetuses	GeneRIF Biological Term Annotations	1.0	null
K562_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245162
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0574453
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03945
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10809641-DataSheet3.pdf-156-HAND2_HAND2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836637
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.602
7403_RNMT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67141
K562_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.049971
transcription	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64L-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22487
Mesonephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.096
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
Triple Negative Breast Neoplasms	DisGeNET Gene-Disease Associations	1.0	null
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0566695
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11941
RBM3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178904
virion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.03779
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.74602
KYSE410	CCLE Cell Line Gene CNV Profiles	1.0	2.16957
assay	GeneRIF Biological Term Annotations	1.0	null
PMC9579318-Table_3.xlsx-All_gene_lists-TANG_SENESCENCE_TP53_TARGETS_UP_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54844
Adult Erythroleukemia	DisGeNET Gene-Disease Associations	1.0	null
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
describes	GeneRIF Biological Term Annotations	1.0	null
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.042672
Other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.388
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.067839
6697_PPP4R1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623369
frhk4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
K562_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0413917
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05487
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
sickle cell anemia	GWASdb SNP-Disease Associations	1.0	1.94201
RIPPLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62732
Chloracne	DisGeNET Gene-Disease Associations	1.0	null
pkcalpha	GeneRIF Biological Term Annotations	1.0	null
betaglobin	GeneRIF Biological Term Annotations	1.0	null
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558441
CBX3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193599
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
Inner mucus layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.609
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63807
HBE1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.047728
transfer	GeneRIF Biological Term Annotations	1.0	null
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.20784
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
MTCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29368
synthesis	GeneRIF Biological Term Annotations	1.0	null
5368_MYB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.78334
5861_NUDC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542766
parolfactory gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24033
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9437
XD-68-MP63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376617
HDAC1	ENCODE Transcription Factor Targets	1.0	null
combined	GeneRIF Biological Term Annotations	1.0	null
K562_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0287005
DRG1	Pathway Commons Protein-Protein Interactions	1.0	null
DMS273_LUNG	CCLE Cell Line Proteomics	1.0	2.0274
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160998
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210545
TOP2A	Pathway Commons Protein-Protein Interactions	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0599
Globin	InterPro Predicted Protein Domain Annotations	1.0	null
PSMA4	Pathway Commons Protein-Protein Interactions	1.0	null
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0307939
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9616
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.14438
2394_DTYMK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508647
MDN1	Pathway Commons Protein-Protein Interactions	1.0	null
U87MG	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04952
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.814
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS21	Pathway Commons Protein-Protein Interactions	1.0	null
Ischemic bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40253
BUB3	Pathway Commons Protein-Protein Interactions	1.0	null
OTUD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31004
K562_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0487357
PIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52367
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8639438-41388_2021_1938_MOESM3_ESM.xlsx-ZNF545-IP_group-Gene_Name_ZFP82	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.706
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051251
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22226
contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.13032
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dbsfrhl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
repeat	GeneRIF Biological Term Annotations	1.0	null
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267756
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60372
K562_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0635585
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5208
Erythroleukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.443
496100332_HIP_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	8.83662
9398_TTI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531563
9219_TPX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76698
Primary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
CHD4	Pathway Commons Protein-Protein Interactions	1.0	null
nli	GeneRIF Biological Term Annotations	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05273
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530535
CRCGN013_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26491
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6471
cation binding	GO Molecular Function Annotations 2015	1.0	null
K562_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287019
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.930133
causes	GeneRIF Biological Term Annotations	1.0	null
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
FSCN1	Pathway Commons Protein-Protein Interactions	1.0	null
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
NAPA	Pathway Commons Protein-Protein Interactions	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.553
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24622
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
nucleoplasm part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048338
other	GeneRIF Biological Term Annotations	1.0	null
promoter	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p38	GeneRIF Biological Term Annotations	1.0	null
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0549003
18199535-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22254
GSE245354_6_v_4_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85287
EIF4G1	Pathway Commons Protein-Protein Interactions	1.0	null
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07136
upregulate	GeneRIF Biological Term Annotations	1.0	null
hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.814283
SRM	Pathway Commons Protein-Protein Interactions	1.0	null
Buccal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
Human - Fetal Development - L2 - Heart-Lymphoid cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0382693
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ADAMTSL4	Pathway Commons Protein-Protein Interactions	1.0	null
2973_FARSA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.502826
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3985
6323_PIAS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538157
MEG-01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835507
DBN1	Pathway Commons Protein-Protein Interactions	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
X-linked severe combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826109
hence	GeneRIF Biological Term Annotations	1.0	null
trans	GeneRIF Biological Term Annotations	1.0	null
Buccal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.882
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50766
coactivator	GeneRIF Biological Term Annotations	1.0	null
K562_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02604
K562_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0549319
496100446_TCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.20158
K562_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250892
upon	GeneRIF Biological Term Annotations	1.0	null
3343_GFI1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525812
Prostate adenocarcinoma_PRAD_TCGA-EJ-7786-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5647233__F4	PFOCR Pathway Figure Associations 2024	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	1.58262
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35597
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0379
CRCGN015_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04585
nfy	GeneRIF Biological Term Annotations	1.0	null
ANP32B	Pathway Commons Protein-Protein Interactions	1.0	null
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0288287
K562_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0729489
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
MONOMAC1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.27197
BOLA2	Pathway Commons Protein-Protein Interactions	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.845902
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197586
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76529
IGF2R	Pathway Commons Protein-Protein Interactions	1.0	null
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8276
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
GOLGA7	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
Mean corpuscular hemoglobin concentration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.583179
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978105
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0446839
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.86792
PPIL1	Pathway Commons Protein-Protein Interactions	1.0	null
SCAP	Pathway Commons Protein-Protein Interactions	1.0	null
Yolk sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46473
EEF1D	Pathway Commons Protein-Protein Interactions	1.0	null
transcriptional	GeneRIF Biological Term Annotations	1.0	null
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
whereas	GeneRIF Biological Term Annotations	1.0	null
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017443
normocytic anemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.682635
hsa-miR-500b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31639
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0994648
FAM89B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7983
ACAT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.34058
autosomal recessive disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.06123
establishment of localization	GO Biological Process Annotations 2015	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	2.04692
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.06433
hbg1	GeneRIF Biological Term Annotations	1.0	null
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
placenta_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.51679
present	GeneRIF Biological Term Annotations	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
Megakaryocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.472
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0141
gut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.507849
K562_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187428
flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.405935
autonomously	GeneRIF Biological Term Annotations	1.0	null
Stem nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
DNAJC7	Pathway Commons Protein-Protein Interactions	1.0	null
different	GeneRIF Biological Term Annotations	1.0	null
monogenic disease	GWASdb SNP-Disease Associations	1.0	0.965063
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0895066
ACP1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMD13	Pathway Commons Protein-Protein Interactions	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.246442
PMC10019818-Table_1.xlsx-GSEA_6-TANG_SENESCENCE_TP53_TARGETS_UP_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
7144_RBBP8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.59107
ZNF143	ENCODE Transcription Factor Targets	1.0	null
RAP2B	Pathway Commons Protein-Protein Interactions	1.0	null
augments	GeneRIF Biological Term Annotations	1.0	null
reports	GeneRIF Biological Term Annotations	1.0	null
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285064
PRDM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49608
Penile disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10728
hemolytic anemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.682635
anemia	HPO Gene-Disease Associations	1.0	null
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244277
globin	GeneRIF Biological Term Annotations	1.0	null
variants	GeneRIF Biological Term Annotations	1.0	null
8645_TACC3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.599891
K562_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0404789
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3792
RPL18A	Pathway Commons Protein-Protein Interactions	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866902
2336_DONSON_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.829097
Malaria	GWAS Catalog SNP-Phenotype Associations 2025	1.0	6.83979
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0341305
10025_ZC3H4_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517982
K562_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0428998
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.11743
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00347
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.06438
Sickle Cell-Ss Disease	DisGeNET Gene-Disease Associations	1.0	null
Autosomal dominant intellectual developmental disorder 43	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061128
Hemoglobin complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.896534
modulate	GeneRIF Biological Term Annotations	1.0	null
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
Enterocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.772
Red blood cell (erythrocyte)_Blood vessel_Human	CellMarker Gene-Cell Type Associations	1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3053
K562_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0650964
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01075
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
methylation	GeneRIF Biological Term Annotations	1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	4.45639
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
MV411	Achilles Cell Line Gene Essentiality Profiles	1.0	2.05062
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
gata2	GeneRIF Biological Term Annotations	1.0	null
alternative	GeneRIF Biological Term Annotations	1.0	null
K562_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0693247
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
1289_CCDC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577371
Lobular Carcinoma In Situ Of Breast	DisGeNET Gene-Disease Associations	1.0	null
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266606
GABARAPL2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291928
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
4221_ITFG2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.722309
CTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22318
EIF4G2	Pathway Commons Protein-Protein Interactions	1.0	null
SNAP29	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7786-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65748
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.501488
Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058321
lung	HPA Tissue Protein Expression Profiles	1.0	0.864208
Delta Beta^0^ Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
interstitial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RCC1	Pathway Commons Protein-Protein Interactions	1.0	null
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
C1orf35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33945
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47373
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136002
10484_ZNF592_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.694672
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.142137
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181996
del	GeneRIF Biological Term Annotations	1.0	null
4646_LRIG2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605016
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4241
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.01212
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3C	Pathway Commons Protein-Protein Interactions	1.0	null
7950_SLBP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04116
cre	GeneRIF Biological Term Annotations	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958259
11132_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524792
PCM1	Pathway Commons Protein-Protein Interactions	1.0	null
gata1	GeneRIF Biological Term Annotations	1.0	null
oxygen transport	GO Biological Process Annotations 2023	1.0	null
Human - Fetal Development - L2 - Liver-Erythroblasts	HuBMAP Azimuth Cell Type Annotations	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065754
19204204-SupplementaryTable1	GeneSigDB Published Gene Signatures	1.0	null
gas transport	GO Biological Process Annotations 2015	1.0	null
ZBTB33_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CL1-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0975
CD2AP	Pathway Commons Protein-Protein Interactions	1.0	null
MCM2	Pathway Commons Protein-Protein Interactions	1.0	null
ATAD3A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869462
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.582784
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-11A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	1.63233
PKP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46936
K562_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.038302
Hematology traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
beta-thalassemia intermedia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.435
EIF3A	Pathway Commons Protein-Protein Interactions	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156696
ZYX	Pathway Commons Protein-Protein Interactions	1.0	null
Human - Fetal Development - L2 - Liver-Mesothelial cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC11923433-BLOOD_BLD-2024-025618-mmc2.xlsx-S3_Specific_genes_in_CEBPA-dm-Supplemental_Table_3_The_subtype-specific_enriched_marker_genes_in_CEBPA-dm_subtype_patients_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174662
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309689
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.682635
Primary polycythemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.68314
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
suggests	GeneRIF Biological Term Annotations	1.0	null
spermatozoon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373118
PTGES3	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
agamma201	GeneRIF Biological Term Annotations	1.0	null
oxygen binding	GO Molecular Function Annotations 2015	1.0	null
variation	GeneRIF Biological Term Annotations	1.0	null
level	GeneRIF Biological Term Annotations	1.0	null
Logical memory (immediate recall) in normal cognition	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
8720_TBC1D4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54624
indicating	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0376431
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
GTEX-X4EP-0526-SM-3P5YW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00524
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
persistence	GeneRIF Biological Term Annotations	1.0	null
CBL	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94613
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
alpha thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.275801
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997925
876_BORA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.875836
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37005
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.810638
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.536183
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864608
bearing	GeneRIF Biological Term Annotations	1.0	null
coagulation	GO Biological Process Annotations 2015	1.0	null
Factors involved in megakaryocyte development and platelet production	Reactome Pathways 2024	1.0	null
1411_CDC7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.5422
PYCR1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFY	Pathway Commons Protein-Protein Interactions	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66622
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.059
K562_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0620485
K562_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0348368
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
K562_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.094339
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20058
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
NCIN87	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39919
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
1545_CHAF1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.755101
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.548982
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0635708
K562_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0374757
brazilian	GeneRIF Biological Term Annotations	1.0	null
KIF2C	Pathway Commons Protein-Protein Interactions	1.0	null
lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0421543
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23919
P4HTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40196
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.421604
8578_SUGT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.982728
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1996
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925367
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902701
goblet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219047
PICALM	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
hba2	GeneRIF Biological Term Annotations	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.26547
hemoglobin complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4695
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22979
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68747
breakpoints	GeneRIF Biological Term Annotations	1.0	null
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13177
factors	GeneRIF Biological Term Annotations	1.0	null
DPRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58998
KCNQ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40428
blood	GTEx Tissue Gene Expression Profiles	1.0	2.18987
Platelet alpha granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.920498
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902466
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.64965
PMC4905481-oncotarget-07-11397-s002.xlsx-CtBP1_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
saliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.39376
A2058	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.31044
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
LPGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83651
Villous cytotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183476
4897_MCM10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.41973
8146_SMARCB1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.833257
abnormality of skin morphology	HPO Gene-Disease Associations	1.0	null
EIF4E	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205274
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
Parasitic infectious disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.748
K562_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0750763
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294055
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
switching	GeneRIF Biological Term Annotations	1.0	null
abnormality of bone marrow cell morphology	HPO Gene-Disease Associations	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05575
fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.324201
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0365768
Globin-like	InterPro Predicted Protein Domain Annotations	1.0	null
K562_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0626117
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67447
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
FERMT3	Pathway Commons Protein-Protein Interactions	1.0	null
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
erythroid	GeneRIF Biological Term Annotations	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
K562_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0338282
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5459-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydroxyurea	GeneRIF Biological Term Annotations	1.0	null
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0472117
structure	GeneRIF Biological Term Annotations	1.0	null
VKORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69721
GSE131649_4_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
chromosome	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65287
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
box	GeneRIF Biological Term Annotations	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16086
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.506816
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_190_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
ATF7IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81306
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.407919
AK2	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1118_C7ORF26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.67525
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35022
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86158
spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159166
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
NANOG-16153702-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.01959
family	GeneRIF Biological Term Annotations	1.0	null
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094168
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
COLO-320-HSR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
7176_RBM42_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.667847
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179392
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71754
Endometrial Neoplasms	CTD Gene-Disease Associations	1.0	1.0766
MCF7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42995
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6872_PSMD4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.64023
eto2	GeneRIF Biological Term Annotations	1.0	null
Capsaicin	CTD Gene-Chemical Interactions	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
fetal hemoglobin quantitative trait locus 1	OMIM Gene-Disease Associations	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8061-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
beta0thalassemia	GeneRIF Biological Term Annotations	1.0	null
Brain cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03132
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
Erythroid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.545
SAR1B	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
4329_KDM5C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.822352
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H1FX	Pathway Commons Protein-Protein Interactions	1.0	null
histiocytosis-lymphadenopathy plus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
EIF6	Pathway Commons Protein-Protein Interactions	1.0	null
PHF5A	Pathway Commons Protein-Protein Interactions	1.0	null
snp	GeneRIF Biological Term Annotations	1.0	null
PMC12358259-Image1.pdf-0-ZNF160_ZNF160	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87394
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	1.0	3.27323
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227207
K562_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369478
ion binding	GO Molecular Function Annotations 2015	1.0	null
CWF19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06342
K562_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0426288
GABARAPL2	Hub Proteins Protein-Protein Interactions	1.0	null
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894565
K562_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0296525
DHCR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85564
7636_SAFB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509903
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21913
LI7	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
validating	GeneRIF Biological Term Annotations	1.0	null
inner CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40113
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.682635
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12483
brain cortex cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
4384_KIF20A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16507
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.872029
remaining	GeneRIF Biological Term Annotations	1.0	null
BXPC3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.08369
gata	GeneRIF Biological Term Annotations	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17794
brg1	GeneRIF Biological Term Annotations	1.0	null
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258898
HDAC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74847
camp	GeneRIF Biological Term Annotations	1.0	null
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
MKRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09505
SPI1	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rearrangements	GeneRIF Biological Term Annotations	1.0	null
manner	GeneRIF Biological Term Annotations	1.0	null
NHP2L1	Pathway Commons Protein-Protein Interactions	1.0	null
3246_GAB2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.65921
RAP1B	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177229
part	GeneRIF Biological Term Annotations	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159548
3246_GAB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.91839
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72049
posterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21446
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09891
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0341425
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0289729
K562_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0805738
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173043
PEX16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55428
701_ATXN1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.824917
NCI-H661	COSMIC Cell Line Gene Mutation Profiles	1.0	null
6517_POLD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.3887
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.87155
CHD-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.752
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.361
PDHA1	Pathway Commons Protein-Protein Interactions	1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.898669
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0750161
controls	GeneRIF Biological Term Annotations	1.0	null
ATXN2L	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0369345
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18889
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989079
liver	HPA Tissue Protein Expression Profiles	1.0	1.60187
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
Small intestine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.773
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35376
SYK	Pathway Commons Protein-Protein Interactions	1.0	null
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
Premature Birth	CTD Gene-Disease Associations	1.0	1.08196
1475_CENPA_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744924
Moh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.917
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12409
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83751
K562_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0309446
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927082
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09211
Erythrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.378
2118_DDX39B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.979525
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.05
Inflammation	CTD Gene-Disease Associations	1.0	1.21271
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866503
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0403657
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.403
NXT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45207
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22566
CUX1	ENCODE Transcription Factor Targets	1.0	null
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.132075
MS (Multiple Sclerosis)_B Cell Lymphocyte_GSE10064	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.03002
18308945-Table1	GeneSigDB Published Gene Signatures	1.0	null
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
7154_RBM12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.916848
PTPN23	Pathway Commons Protein-Protein Interactions	1.0	null
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DDX18	Pathway Commons Protein-Protein Interactions	1.0	null
VARS	Pathway Commons Protein-Protein Interactions	1.0	null
ESD	Pathway Commons Protein-Protein Interactions	1.0	null
htta1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
DDX3Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62084
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0581805
COR-L105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.46978
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.841608
Blood-erythrocyte	Tabula Sapiens Gene-Cell Associations	1.0	2.26779
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2322_DOCK11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17497
Weight Gain	CTD Gene-Disease Associations	1.0	1.62335
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
K562_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0329589
diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.70233
K562_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166056
K562_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0532868
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0319545
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.79882
reporters	GeneRIF Biological Term Annotations	1.0	null
PMC4060771-170289.f1.pdf-537-TEAD3_TEAD3	Rummagene Transcription Factor Associations 2026	1.0	null
MDBK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
K562_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0788436
cases	GeneRIF Biological Term Annotations	1.0	null
Perturb_10147_KO_FAM122A_SRP235545	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318162
increases	GeneRIF Biological Term Annotations	1.0	null
8618_SYF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575724
UPF1	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.84527
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242622
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0188
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07103
CHP212	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60447
useful	GeneRIF Biological Term Annotations	1.0	null
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302295
3862_HNRNPDL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.751431
K562_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0559576
K562_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273517
K562_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324591
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263669
PMC10842785-NIHMS1948219-supplement-3.xlsx-GATA2_sense_vs_antisense-Gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
Dietary Fats	CTD Gene-Chemical Interactions	1.0	null
K562_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.217243
ZNF160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13897
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
16964388-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.13845
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37399
increasing	GeneRIF Biological Term Annotations	1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4611
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160866
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147235
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052222
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8866
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.676402
genetic	GeneRIF Biological Term Annotations	1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03465
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0561
K562_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286647
K562_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.055012
PADI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40118
STON2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01473
reduces	GeneRIF Biological Term Annotations	1.0	null
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
same	GeneRIF Biological Term Annotations	1.0	null
BAG3	Pathway Commons Protein-Protein Interactions	1.0	null
HS766T	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.24798
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45565
RCBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33828
Hepatomegaly	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05763
9188_TOX4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54343
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.115206
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
CSNK1A1	Pathway Commons Protein-Protein Interactions	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.509186
Thoracic thymus_CT1_erythroid	HuBMAP ASCT+B Annotations	1.0	null
5317_MTHFD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.644631
UCK2	Pathway Commons Protein-Protein Interactions	1.0	null
RAC2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.050101
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1CC	Pathway Commons Protein-Protein Interactions	1.0	null
LYPLA1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1703	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77674
pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268828
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29678
SARS-CoV MA15_Day2-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.57919
5945_OPA3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544661
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
HCC364	Achilles Cell Line Gene Essentiality Profiles	1.0	1.62939
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0329186
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54324
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Chorionic plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828149
Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
10250_ZNF267_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582652
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Sickle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.406
7127_RASSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574254
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0974452
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.141232
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0404711
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.649615
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2938
activates	GeneRIF Biological Term Annotations	1.0	null
PPA1	Pathway Commons Protein-Protein Interactions	1.0	null
Fatty acyl-CoA biosynthesis	Reactome Pathways 2024	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
Thalassemia Intermedia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72098
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
CSNK2B	Pathway Commons Protein-Protein Interactions	1.0	null
RAB3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43274
Chloracne	CTD Gene-Disease Associations	1.0	2.88009
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0318039
primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.175384
8438_SRSF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522897
AB-17-DF74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231898
MST1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13356
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0703721
Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32123
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
Extravillous trophoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
NCIH1975_LUNG	CCLE Cell Line Proteomics	1.0	8.94173
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
hereditary	GeneRIF Biological Term Annotations	1.0	null
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209501
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
anemia of inadequate production	HPO Gene-Disease Associations	1.0	null
normoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224993
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1786
Axillary bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0347991
very	GeneRIF Biological Term Annotations	1.0	null
gas transport	GO Biological Process Annotations 2023	1.0	null
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.945306
ribonucleoside-diphosphate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
K562_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0492848
cochlear nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29881
K562_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.04859
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0399976
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.409479
fetal	GeneRIF Biological Term Annotations	1.0	null
18786252-TableS1	GeneSigDB Published Gene Signatures	1.0	null
differentiate	GeneRIF Biological Term Annotations	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903648
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26096
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63359
2276_DNAJA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557583
UC-52-SS41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262462
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TARS	Pathway Commons Protein-Protein Interactions	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15943
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061124
Outer mucus layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
EIF3D	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53182
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16086
abnormality of erythrocytes	HPO Gene-Disease Associations	1.0	null
TNKS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53593
1440_CDK6_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.971105
ACO2	Pathway Commons Protein-Protein Interactions	1.0	null
Bone marrow_CT2_late erythroid	HuBMAP ASCT+B Annotations	1.0	null
Peripheral blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
GTEX-REY6-0426-SM-2TF5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845344
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34559
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0314892
GTEX-RTLS-0726-SM-46MV4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876331
APP	Pathway Commons Protein-Protein Interactions	1.0	null
K562_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250292
Cutaneous porphyria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7601
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
8913_TIMELESS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523386
hemoglobinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.04251
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37059
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
major	GeneRIF Biological Term Annotations	1.0	null
Jejunal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08303
Intestinal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.643
pathways	GeneRIF Biological Term Annotations	1.0	null
genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.06123
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.032533
K562_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0467963
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642196
Distal tubular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
Prostate adenocarcinoma_PRAD_TCGA-CH-5741-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.06123
PMC9437808-mmc5.xlsx-Upstream_regulators-IPA_Upstream_regulator_analysis_genes_that_were_downregulated_in_the_cf-mRNA_of_AZD_treated_group_at_2-hour_post_LPS_time_point_were_used_as_inputs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.046772
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.165
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56783
NAA15	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.101371
camppka	GeneRIF Biological Term Annotations	1.0	null
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029829
heart	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171655
NR2F2	ENCODE Transcription Factor Targets	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965286
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0659628
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.592895
K562_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0552485
sickle cell anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.899924
7163_RBM19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626867
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0357255
lowdose	GeneRIF Biological Term Annotations	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.534937
Edema	CTD Gene-Disease Associations	1.0	1.51734
K562_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132759
EIF4A3	Pathway Commons Protein-Protein Interactions	1.0	null
hbd	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0199
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
2426_DYNLL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.70527
decoy	GeneRIF Biological Term Annotations	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.051419
IRF1	ENCODE Transcription Factor Targets	1.0	null
MACF1	Pathway Commons Protein-Protein Interactions	1.0	null
7144_RBBP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528974
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50732
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-8121-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TALDO1	Pathway Commons Protein-Protein Interactions	1.0	null
DLD1	CCLE Cell Line Gene CNV Profiles	1.0	1.39942
OVCAR8	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33616
ACACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36165
K562_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206844
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
Venezuelan equine encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00754
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Splenomegaly	DisGeNET Gene-Phenotype Associations	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
5653_NFU1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554178
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
L363	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09318
MYL4	Pathway Commons Protein-Protein Interactions	1.0	null
PANC1	CCLE Cell Line Gene CNV Profiles	1.0	1.95515
blood microparticle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Human - Fetal Development - L2 - Spleen-Mesothelial cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
nocgmp	GeneRIF Biological Term Annotations	1.0	null
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226945
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Sarcoma_SARC_TCGA-IW-A3M4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0655119
3369_GINS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.13982
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29699
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
PSMA3	Pathway Commons Protein-Protein Interactions	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.733592
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cis	GeneRIF Biological Term Annotations	1.0	null
1325_CCNE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529425
K562_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.132923
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16667
Acute Myeloid Leukemia_LAML_TCGA-AB-2979-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AGFG1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30955
SKHEP1_LIVER	CCLE Cell Line Proteomics	1.0	2.39047
3216_FUBP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.582275
abnormality of the liver	HPO Gene-Disease Associations	1.0	null
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4093
Alpha-Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8795
K562_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169378
5826_NSL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.6908
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47566
QKI	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198848
GSE131649_6_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.196587
K562_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.074842
2414_DUT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06038
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.910096
plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086233
K562_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0415907
1482_CENPI_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602915
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80497
K562_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227775
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.520099
hba	GeneRIF Biological Term Annotations	1.0	null
2426_DYNLL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546019
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
jun	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.225
PAFAH1B3	Pathway Commons Protein-Protein Interactions	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.968044
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0514788
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24622
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52133
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01749
hematopoietic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.682635
K562_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220463
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4452
PMC9203980-NIHMS1797220-supplement-Supplementary_Table_1-5.xlsx-S2-Supplementary_Table_2_Differentially_expressed_genes_in_Control_and_NFIA_depleted_HUDEP2_cells_NFIA	Rummagene Transcription Factor Associations 2026	1.0	null
VCAM1	Pathway Commons Protein-Protein Interactions	1.0	null
FUBP3	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5088-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0552852
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1772
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.01856
embryonic	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15497
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32106
AIMP2	Pathway Commons Protein-Protein Interactions	1.0	null
Alpha thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.676
hematopoietic	GeneRIF Biological Term Annotations	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30105
RAPGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68867
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3173
289_AMD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545422
PLEC	Pathway Commons Protein-Protein Interactions	1.0	null
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
hpfh	GeneRIF Biological Term Annotations	1.0	null
Microcytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.153
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03303
K562_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0388897
7068_RAD51C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.789338
Beta thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.286
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28264
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.091081
PSMA6	Pathway Commons Protein-Protein Interactions	1.0	null
spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.189621
NFYA	JASPAR Predicted Transcription Factor Targets	1.0	null
derivatives	GeneRIF Biological Term Annotations	1.0	null
GTEX-XV7Q-0005-SM-4BRWI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2395
Chromosomal region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.795
KU-812 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.06123
19922785-Table3	GeneSigDB Published Gene Signatures	1.0	null
K562_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0359544
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3468-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPS15L1	Pathway Commons Protein-Protein Interactions	1.0	null
Delta-Beta Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
K562_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155226
14768006-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267679
Perinatal necrotizing enterocolitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
SNX3	Pathway Commons Protein-Protein Interactions	1.0	null
cytosolic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3948_HSD17B10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.657576
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01184
HDAC2	ENCODE Transcription Factor Targets	1.0	null
K562_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0471579
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.85839
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75938
eklf	GeneRIF Biological Term Annotations	1.0	null
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851787
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34541
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of cells of the erythroid lineage	GWASdb SNP-Phenotype Associations	1.0	0.49797
3518_GPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636295
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03465
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5055
SLR25	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13006
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.2156
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
3371_GINS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597225
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0608092
Erythroid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.154
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96003
Glucosidase II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.543
sites	GeneRIF Biological Term Annotations	1.0	null
identifying	GeneRIF Biological Term Annotations	1.0	null
K562_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0512683
ZNF559	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51874
9502_UBE2F_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641549
3706_HESX1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50052
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77665
SLC2A1	Pathway Commons Protein-Protein Interactions	1.0	null
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
629_ATIC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.561558
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
OP-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050629
Acute chest syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.111
MLLT4	Pathway Commons Protein-Protein Interactions	1.0	null
RAC1	Pathway Commons Protein-Protein Interactions	1.0	null
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.30969
B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.142
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74255
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.866125
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33217
6842_PSMA2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00842
NCIH1650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49455
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.047214
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7851
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161863
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44032
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177658
K562_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0659441
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.277
K562_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208375
TFRC	Pathway Commons Protein-Protein Interactions	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.54656
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSTK1	Pathway Commons Protein-Protein Interactions	1.0	null
elevated	GeneRIF Biological Term Annotations	1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48479
Erythroid cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
K562_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0444212
RPS20	Pathway Commons Protein-Protein Interactions	1.0	null
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55956
Erythroleukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955461
496100295_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43449
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075482
PABPC4	Pathway Commons Protein-Protein Interactions	1.0	null
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.596069
GTEX-OIZH-0726-SM-3NB1I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999971
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.41251
synergism	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
Endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.396
8098_SLC4A7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55217
histone	GeneRIF Biological Term Annotations	1.0	null
SH3BGRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32959
satb	GeneRIF Biological Term Annotations	1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932519
vitro	GeneRIF Biological Term Annotations	1.0	null
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247463
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of cells of the erythroid lineage	HPO Gene-Disease Associations	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.669171
3195_FOXS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.979323
Beta Thalassemia Intermedia	DisGeNET Gene-Disease Associations	1.0	null
K562_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262365
CHD4	ENCODE Transcription Factor Targets	1.0	null
K562_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187262
K562_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146111
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
STRAP	Pathway Commons Protein-Protein Interactions	1.0	null
cytosolic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.502288
Human - Fetal Development - L2 - Liver-Myeloid cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.14964
cl-48 cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
812_BCR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.942979
SDHB	Pathway Commons Protein-Protein Interactions	1.0	null
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09296
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050855
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18109
15090461-Table4	GeneSigDB Published Gene Signatures	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0518831
vp8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	3.135
EIF3K	Pathway Commons Protein-Protein Interactions	1.0	null
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0436767
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Human - Fetal Development - L2 - Spleen-Erythroblasts	HuBMAP Azimuth Cell Type Annotations	1.0	null
K562_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159392
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2039
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
RBM4	Pathway Commons Protein-Protein Interactions	1.0	null
beta-thalassemia major	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.52
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02617
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96995
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993417
496100653_PCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3833
GTEX-SUCS-0226-SM-32PLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13226
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244252
granulation tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.360036
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31907
CSNK1A1L	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.046591
repressor	GeneRIF Biological Term Annotations	1.0	null
K562_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226039
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0561
erythroid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224993
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
tbp	GeneRIF Biological Term Annotations	1.0	null
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182334
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0491872
interstitial cell of cajal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
prmt5dependent	GeneRIF Biological Term Annotations	1.0	null
KRT18	Pathway Commons Protein-Protein Interactions	1.0	null
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
TM9SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69191
functions	GeneRIF Biological Term Annotations	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03465
PMC10842785-NIHMS1948219-supplement-3.xlsx-GATA1_Sense_vs_Neg-Gene_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
7641_SALL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611723
2031_DAXX_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55644
correlated	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-11A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154961,GSE154963_4_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1411_CDC7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.625465
Hemoglobin E disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0561896
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.9883
4384_KIF20A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12265
K562_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0511298
computational	GeneRIF Biological Term Annotations	1.0	null
CCT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42327
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75624
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214017
Alpha^0^ Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0363306
K562_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185709
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.826444
Acute diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.791
Hemoglobin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.985
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1584
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18929
Methemoglobinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.666
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
FARSB	Pathway Commons Protein-Protein Interactions	1.0	null
19933690-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
VAMP8	Pathway Commons Protein-Protein Interactions	1.0	null
1569_CHEK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.646575
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.906086
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0602498
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06362
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.559
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30536
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44503
healthy	GeneRIF Biological Term Annotations	1.0	null
K562_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0556869
CRCGN014_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24827
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882809
CE-72-GF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492096
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889898
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018311
Hypertrophy	CTD Gene-Disease Associations	1.0	1.39142
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
CIRBP	Pathway Commons Protein-Protein Interactions	1.0	null
TPR	Pathway Commons Protein-Protein Interactions	1.0	null
erythropoiesis	GeneRIF Biological Term Annotations	1.0	null
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530438
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280477
GNAI3	Pathway Commons Protein-Protein Interactions	1.0	null
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180442
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0433838
GSE146982_0_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
beta-Thalassemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.38254
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.182661
Human - Fetal Development - L2 - Intestine-Erythroblasts	HuBMAP Azimuth Cell Type Annotations	1.0	null
carbon dioxide transport	GO Biological Process Annotations 2025	1.0	null
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27842
llcmk2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.315
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05267
K562_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0820742
K562_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019992
villus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180438
MYL12B	Pathway Commons Protein-Protein Interactions	1.0	null
HEMOGLOBIN F	ClinVar Gene-Phenotype Associations 2025	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314409
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.794792
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0416428
GTPBP4	Pathway Commons Protein-Protein Interactions	1.0	null
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6913
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3731_HINFP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.942673
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6992
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49569
Malaria	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.748
Golgi cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
CTSD	Pathway Commons Protein-Protein Interactions	1.0	null
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12073
one-carbon compound transport	GO Biological Process Annotations 2023	1.0	null
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
FBXO27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90672
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0423269
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58937
7255_RFT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.5926
single-organism transport	GO Biological Process Annotations 2015	1.0	null
K562_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.128821
ACTN4	Pathway Commons Protein-Protein Interactions	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.940364
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053006
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58516
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48431
TMUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98075
K562_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216177
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949503
8019_SLC27A4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.68352
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7572
PIK3R2	Pathway Commons Protein-Protein Interactions	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.824
STOM	Pathway Commons Protein-Protein Interactions	1.0	null
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07114
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22566
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903648
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0600668
Cholera	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.322
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03909
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0458514
site	GeneRIF Biological Term Annotations	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910557
K562_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.036206
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
KRT2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330299
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0644214
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.024
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29225
bone marrow	HPA Tissue Gene Expression Profiles	1.0	1.24888
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0391097
OSBPL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76485
Hyperplasia	CTD Gene-Disease Associations	1.0	1.20881
TOMM34	Pathway Commons Protein-Protein Interactions	1.0	null
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212735
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.533309
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978105
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0505298
CRCGN015_MCF10A.WT.HP_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08614
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903648
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0571398
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.903075
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
Human - Fetal Development - L2 - Adrenal-Erythroblasts	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_153_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hemoglobin C disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0825169
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
K562_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0499257
developmentally	GeneRIF Biological Term Annotations	1.0	null
PIKFYVE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18713
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0614849
7484_RPLP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.642396
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052179
GTEX-XQ8I-1426-SM-4BOPW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836736
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46276
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
UBL5	Pathway Commons Protein-Protein Interactions	1.0	null
Human - Bone Marrow - L2 - Late Erythroid	HuBMAP Azimuth Cell Type Annotations	1.0	null
K562_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0548698
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.19927
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35224
UBTF	ENCODE Transcription Factor Targets	1.0	null
TTC9C	Pathway Commons Protein-Protein Interactions	1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
CLDN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27842
KELLY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53389
K562_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0622662
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STIP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0919198
Extravillous trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0370765
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.99954
general	GeneRIF Biological Term Annotations	1.0	null
autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.06123
CRCGN017_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19453
GALK1	Pathway Commons Protein-Protein Interactions	1.0	null
GART	Pathway Commons Protein-Protein Interactions	1.0	null
SF268	CCLE Cell Line Gene CNV Profiles	1.0	1.56216
abnormality of the abdomen	HPO Gene-Disease Associations	1.0	null
K562_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210395
hemoglobin	GeneRIF Biological Term Annotations	1.0	null
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.811001
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986474
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994027
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286306
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0411507
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2009_LUNG	CCLE Cell Line Proteomics	1.0	3.90104
produced	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49088
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0351819
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal dominant beta thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
LARP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0587364
DNPEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38313
IB-08-VY61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.66647
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22832
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
days	GeneRIF Biological Term Annotations	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5141
K562_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0669266
chromatin	GeneRIF Biological Term Annotations	1.0	null
acid	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-137	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
8382_SPTA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.731483
Beta thalassemia/hemoglobin E disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.45229
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32064
3370_GINS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.799894
Disorders of Sex Development	CTD Gene-Disease Associations	1.0	1.1129
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60423
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01712
Interstitial cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.511
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744841
Hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.795
presence	GeneRIF Biological Term Annotations	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973005
SSRP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32473
gpcrs	GeneRIF Biological Term Annotations	1.0	null
RT4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35643
Lung squamous cell carcinoma_LUSC_TCGA-60-2698-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056262
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Congenital dyserythropoietic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
subcallosal cingulate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49243
abnormality of metabolism/homeostasis	HPO Gene-Disease Associations	1.0	null
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta	GeneRIF Biological Term Annotations	1.0	null
K562_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310861
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0314874
cause	GeneRIF Biological Term Annotations	1.0	null
EBNA1BP2	Pathway Commons Protein-Protein Interactions	1.0	null
jvm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
K562_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0791967
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999641
9548_UBR5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.955814
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.14977
polymorphism	GeneRIF Biological Term Annotations	1.0	null
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0459149
hemoglobin alpha binding	GO Molecular Function Annotations 2023	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965286
3650_HBG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.507958
supports	GeneRIF Biological Term Annotations	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35512
ARL2	Pathway Commons Protein-Protein Interactions	1.0	null
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060944
K562_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0721502
POU5F1	ChEA Transcription Factor Targets	1.0	null
H3K36me3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35593
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
VAPA	Pathway Commons Protein-Protein Interactions	1.0	null
1784_COPS7B_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.910549
JIMT1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03062
anemia	GWASdb SNP-Phenotype Associations	1.0	1.87878
K562_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0301157
Amniotic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
coopted	GeneRIF Biological Term Annotations	1.0	null
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0821126
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.974839
hemoglobin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.575912
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0708406
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
22RV1_PROSTATE	CCLE Cell Line Proteomics	1.0	3.08533
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.967471
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.728
Cooley'S Anemia	DisGeNET Gene-Disease Associations	1.0	null
inhibited	GeneRIF Biological Term Annotations	1.0	null
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.059407
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980802
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8814
HP1BP3	Pathway Commons Protein-Protein Interactions	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.96158
Fatty acid metabolism	Reactome Pathways 2024	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.722809
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.03868
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167459
RCC2	Pathway Commons Protein-Protein Interactions	1.0	null
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.90094
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16813
PMVK	Pathway Commons Protein-Protein Interactions	1.0	null
NUP93	Pathway Commons Protein-Protein Interactions	1.0	null
differential	GeneRIF Biological Term Annotations	1.0	null
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052033
PRDX6	Pathway Commons Protein-Protein Interactions	1.0	null
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36796
congenital hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05639
RBBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91647
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257592
silences	GeneRIF Biological Term Annotations	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06714
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52
IPC298_SKIN	CCLE Cell Line Proteomics	1.0	2.0274
K562_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0651567
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
ITGA5	Pathway Commons Protein-Protein Interactions	1.0	null
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29563
7417_RP9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75493
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.505537
QARS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898697
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52582
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0398577
JUN	ENCODE Transcription Factor Targets	1.0	null
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061333
K562_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0537919
8635_SYTL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.658051
haptoglobin-hemoglobin complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0824
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56965
CTCF	ENCODE Transcription Factor Targets	1.0	null
237_AKIRIN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.707719
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0647124
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	5.34921
tata	GeneRIF Biological Term Annotations	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
CCAR1	Pathway Commons Protein-Protein Interactions	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.0776
RPL7	Pathway Commons Protein-Protein Interactions	1.0	null
TF-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
Melorheostosis, Isolated	DisGeNET Gene-Disease Associations	1.0	null
T24_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.75046
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07126
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55884
6290_PHF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.938376
HEL-92.1.7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PPT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1876
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0495966
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.313
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990647
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0761995
placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.556
direct	GeneRIF Biological Term Annotations	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08624
K562_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275961
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMC5	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.058661
PLEKHO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92628
Beta^0^ Thalassemia	DisGeNET Gene-Disease Associations	1.0	null
approach	GeneRIF Biological Term Annotations	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286507
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252708
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05326
Pallor	DisGeNET Gene-Phenotype Associations	1.0	null
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
Thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.254
hepatomegaly	HPO Gene-Disease Associations	1.0	null
ALDH18A1	Pathway Commons Protein-Protein Interactions	1.0	null
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90906
PMC8490503-thnov11p9519s3.xlsx-Proteins_High_MLL-Gene_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03273
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0745134
OVCAR4	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.06493
GTEX-QEL4-0426-SM-3GACZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06991
ggamma196	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.79383
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
K562_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0498561
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66074
epsilon	GeneRIF Biological Term Annotations	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.52148
9391_TTC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510094
EPS15	Pathway Commons Protein-Protein Interactions	1.0	null
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09517
DHX16	Pathway Commons Protein-Protein Interactions	1.0	null
inner CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.880644
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.133
alphagamma	GeneRIF Biological Term Annotations	1.0	null
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0376932
K562_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298936
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896302
16542501-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
RPL15	Pathway Commons Protein-Protein Interactions	1.0	null
FL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
albanian	GeneRIF Biological Term Annotations	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1827
cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208973
outer CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26272
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997353
Sweet Syndrome	DisGeNET Gene-Disease Associations	1.0	null
K562_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0434279
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12549
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0466223
cooperative	GeneRIF Biological Term Annotations	1.0	null
K562_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.104048
K562_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029373
STMN1	Pathway Commons Protein-Protein Interactions	1.0	null
SEC31A	Pathway Commons Protein-Protein Interactions	1.0	null
FUOV1	CCLE Cell Line Gene CNV Profiles	1.0	1.66797
GNB2L1	Pathway Commons Protein-Protein Interactions	1.0	null
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33733
subunits	GeneRIF Biological Term Annotations	1.0	null
CHMP2A	Pathway Commons Protein-Protein Interactions	1.0	null
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	7.10404
Pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.954
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07381
SK-MEL-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CACYBP	Pathway Commons Protein-Protein Interactions	1.0	null
hbg2	GeneRIF Biological Term Annotations	1.0	null
compound	GeneRIF Biological Term Annotations	1.0	null
postulated	GeneRIF Biological Term Annotations	1.0	null
HMGB2	Pathway Commons Protein-Protein Interactions	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04088
NANOG-16153702-HESC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
3979_HSPA8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.821218
K562_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0528878
repressive	GeneRIF Biological Term Annotations	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47T-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1790_COQ10B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.762994
UTP18	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892471
intestine-407 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
abnormality of bone marrow cell morphology	GWASdb SNP-Phenotype Associations	1.0	0.401802
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.858783
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974367
Retrotransposon nucleocapsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.804
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191351
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
MBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95527
Renal epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.551
VCAP_PROSTATE	CCLE Cell Line Proteomics	1.0	5.59512
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0705213
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890175
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2742
K562_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222416
Hpfh Deletion Type	DisGeNET Gene-Disease Associations	1.0	null
Logical memory (delayed recall) in normal cognition	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.7
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Ghosal hematodiaphyseal syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
KIF5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80057
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240216
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47029
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.46097
Tobacco Smoke Pollution	CTD Gene-Chemical Interactions	1.0	null
3651_HBG2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.580065
K562_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0348665
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904203
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
4900_MCM3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736386
7070_RAD51_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.709603
Intussusception	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.89129
binds	GeneRIF Biological Term Annotations	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.19412
biological regulation	GO Biological Process Annotations 2015	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.904989
MCM6	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.85412
activator	GeneRIF Biological Term Annotations	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21353
anemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.682635
K562_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.070839
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
recruitments	GeneRIF Biological Term Annotations	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05487
3084_FIGLA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587976
325_ANKRD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12107
IMR-90 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
2966_FANCI_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631239
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08239
UBAP2L	Pathway Commons Protein-Protein Interactions	1.0	null
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
silencing	GeneRIF Biological Term Annotations	1.0	null
NDUFA2	Pathway Commons Protein-Protein Interactions	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051358
8154_SMARCE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507155
UBR4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27032
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0748467
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0418556
Myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.977
roles	GeneRIF Biological Term Annotations	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56445
Acute Myeloid Leukemia_LAML_TCGA-AB-2915-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
3286_GART_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.973006
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45812
Reticulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.891
Saliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.421
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262218
PRRC2C	Pathway Commons Protein-Protein Interactions	1.0	null
pre-eclampsia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33107
4902_MCM5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553986
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
1972_CWC22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.840154
carbon dioxide transport	GO Biological Process Annotations 2023	1.0	null
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0507261
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29888
formation	GeneRIF Biological Term Annotations	1.0	null
3372_GINS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.56123
IPO7	Pathway Commons Protein-Protein Interactions	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610864
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5896
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Golgi cisterna membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
HEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
consistent	GeneRIF Biological Term Annotations	1.0	null
CHMP4B	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
beta thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01512
TE1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88431
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.087388
CRCGN016_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01963
Osteonecrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
Blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9616
revealed	GeneRIF Biological Term Annotations	1.0	null
ATP5I	Pathway Commons Protein-Protein Interactions	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.12703
placenta	HPA Tissue Gene Expression Profiles	1.0	2.24804
MAPK1	Pathway Commons Protein-Protein Interactions	1.0	null
KRT19	Pathway Commons Protein-Protein Interactions	1.0	null
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889984
provides	GeneRIF Biological Term Annotations	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MSN	Pathway Commons Protein-Protein Interactions	1.0	null
allele	GeneRIF Biological Term Annotations	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.12193
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70801
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.37505
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54303
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.84582
molecular_function	GO Molecular Function Annotations 2015	1.0	null
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0414542
K562_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0366133
result	GeneRIF Biological Term Annotations	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.46172
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
SUDHL6	CCLE Cell Line Gene CNV Profiles	1.0	1.32761
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
stem	GeneRIF Biological Term Annotations	1.0	null
mi2	GeneRIF Biological Term Annotations	1.0	null
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5077-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0994848
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20082
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0750078
5933_OGT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.39402
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08058
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38723
SRSF9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
zona incerta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17014
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1036
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-01B-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18480837-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Fetal hemoglobin quantitative trait locus 1	ClinVar Gene-Phenotype Associations	1.0	null
erythrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.644074
NCIH292_LUNG	CCLE Cell Line Proteomics	1.0	3.08172
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903648
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
Parasitic protozoa infectious disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.748
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.157943
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
remodeling	GeneRIF Biological Term Annotations	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0508222
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0421396
fatty	GeneRIF Biological Term Annotations	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.24683
continued	GeneRIF Biological Term Annotations	1.0	null
Gut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636024
Sickle cell anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.741
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16803
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430304
DIMT1	Pathway Commons Protein-Protein Interactions	1.0	null
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.721
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829307
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
K562_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151319
VPS35	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0645744
NUP188	Pathway Commons Protein-Protein Interactions	1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18202
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81821
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
OV90	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05607
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294297
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0326885
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6197
CRCGN016_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06373
APUD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53856
IST1	Pathway Commons Protein-Protein Interactions	1.0	null
RT11284	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33624
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
Labellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.764
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Bone marrow_CT2_late erythroid	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
APC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26958
NTPCR	Pathway Commons Protein-Protein Interactions	1.0	null
Acute erythroid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
MBNL1	Pathway Commons Protein-Protein Interactions	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836261
K562_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0453022
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59862
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901906
Normoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77418
RCC-JW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
8499_STAT5B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10224
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
KDM5B	ENCODE Transcription Factor Targets	1.0	null
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
sickle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03829
MEMO1	Pathway Commons Protein-Protein Interactions	1.0	null
168_ADSS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609853
HCC2814	CCLE Cell Line Gene CNV Profiles	1.0	1.45712
connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185617
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347242
hemostasis	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0386721
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.06543
MSI2	Pathway Commons Protein-Protein Interactions	1.0	null
definitive	GeneRIF Biological Term Annotations	1.0	null
KIFBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42997
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275032
Adrenal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
MKN7	CCLE Cell Line Gene CNV Profiles	1.0	2.27973
activate	GeneRIF Biological Term Annotations	1.0	null
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
MCM7	Pathway Commons Protein-Protein Interactions	1.0	null
IGF2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73669
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055913
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4149371-pone.0105180.s010.xls-OCT4-GENE_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIDINS220	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0507512
PRPF3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0598522
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.455613
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.542215
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Priapism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
mir210	GeneRIF Biological Term Annotations	1.0	null
SARS	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07365
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0529839
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21806
K562_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022506
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291176
Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
10213_ZNF219_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.647322
anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.580828
oxygen transport	GO Biological Process Annotations 2025	1.0	null
posterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.940259
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.849771
ACTR3	Pathway Commons Protein-Protein Interactions	1.0	null
NPIPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75638
K562_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0975381
where	GeneRIF Biological Term Annotations	1.0	null
K562_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236197
ANKRD17	Pathway Commons Protein-Protein Interactions	1.0	null
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.646631
derivative	GeneRIF Biological Term Annotations	1.0	null
RAB35	Pathway Commons Protein-Protein Interactions	1.0	null
SIRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73248
regulator	GeneRIF Biological Term Annotations	1.0	null
Endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091