association dataset threshold value standardized value SRRT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00805283 ITPK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00510199 WholeBlood BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01365 Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42492 BRD-K23232542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3757 primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.944164 Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80066561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83988 BRD-A85216385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35287 GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles 1.0 1.26655 RELA JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K99252563_QL-XII-47_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.43524 BDH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00382502 NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.40207 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47102 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03282 COL4A4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00592175 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31754 GTEX-QV31-0126-SM-447BP GTEx Tissue Sample Gene Expression Profiles 1.0 1.07332 BRD-K99034771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.812 SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.07393 GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57548 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06348 BRD-K77903467 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27305 primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.861781 hepatocellular GeneRIF Biological Term Annotations 1.0 null BRD-K62707745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31704 JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.08606 GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 0.849859 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857322 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1384 BRD-K02708799_GSK-1059615_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55D-1126-SM-48FEB GTEx Tissue Sample Gene Expression Profiles 1.0 1.13541 CXCL8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00750211 help GeneRIF Biological Term Annotations 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26986 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.26836 hsa-miR-1266 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 hsa-miR-299-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ASPA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00680213 BRD-A06352508_SB 218078_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00575973 Edema CTD Gene-Disease Associations 1.0 1.09011 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925668 Lung squamous cell carcinoma_LUSC_TCGA-18-3416-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64914 BRD-K11105500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17398 IRF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00713534 RAPGEF6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00601865 TP63 ChEA Transcription Factor Targets 1.0 null reaffirm GeneRIF Biological Term Annotations 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.36521 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7409-01A-31R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K64366758_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-A35588707_TENIPOSIDE_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26304 SNU-449 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.860033 BRD-K32906660_Bis-Tyrphostin_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USP28 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00656832 cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38737 GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42042 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.87376 hepatobiliary disease GWASdb SNP-Disease Associations 1.0 0.846913 GTEX-UTHO-0008-SM-4JBID GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64302 BRD-K38131403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40137 BRD-A84941884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60654 doxorubicin_homo sapiens_gpl10558_gse42531 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K45272675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.40748 Sarcoma_SARC_TCGA-3B-A9HJ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIVF001-013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.7294 GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 1.47331 VDR ChEA Transcription Factor Targets 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08177 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.968788 GRANTA519 CCLE Cell Line Gene Expression Profiles 1.0 1.58701 BRD-K46348476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.85344 CAMA1 CCLE Cell Line Gene CNV Profiles 1.0 1.40303 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43P-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZH-0926-SM-48TBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.34516 AHR_01_283 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.14727 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HD-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K69790201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31304 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831186 BRD-K16304302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98089 BRD-K00209945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46287 Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37459038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.53252 Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.47648 HSF1_KD_GDS1733_757_human_HeLa cells - 4 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.2415 GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles 1.0 0.871701 BRD-K06355852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.05083 TP53 JASPAR Predicted Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68756823_FR-180204_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-4072-01B-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hlaa10 GeneRIF Biological Term Annotations 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59404 BRD-K81175414 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15598 BRD-K49755501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05662 MAPK8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00742222 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles 1.0 1.00931 BRD-K79090631_CGP-60474_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUN-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K87794979 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.16348 behcet syndrome GAD Gene-Disease Associations 1.0 null YBX1_01_64 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.67908 GTEX-P44H-0008-SM-48TDW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50013 MAGED1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00647931 significant GeneRIF Biological Term Annotations 1.0 null BRD-K28079391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62422 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13858 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38718 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.914083 BRD-A37645929 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68135 hsa-miR-4651 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 blood GTEx Tissue Gene Expression Profiles 1.0 1.22225 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KM-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.57759 GLYCTK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00578079 MAP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00456009 BRD-K53547009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21424 GTEX-NFK9-0008-SM-4E3JE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18978 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5675-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hcvrelated GeneRIF Biological Term Annotations 1.0 null Inclusion Body Myositides_Muscle tissue_GSE3112 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.52205 hsa-miR-588 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 SLC25A5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00532565 Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the integument GWASdb SNP-Phenotype Associations 1.0 0.308323 Liver hepatocellular carcinoma_LIHC_TCGA-BC-4073-01B-02R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K92544320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86612 GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60674 hsa-miR-1202 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89975 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970602 IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.86339 BRD-K71944493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17171 drug hypersensitivity; hiv infections; [x]human immunodeficiency virus disease GAD Gene-Disease Associations 1.0 null Setleis syndrome_Skin fibroblast_GSE16524 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.725943 behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.085962 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88069 GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25796 trastuzumab_homo sapiens_gpl6947_gse31432 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hiv-1 control GAD Gene-Disease Associations 1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21116 BRD-K63242692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71581 KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.65066 TUBA1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00819695 BRD-K53281329_SYK-inhibitor_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K25525067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.44232 U2AF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00768792 SETD1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00423885 HNF1A_OE_GDS1499_252_human_HEK293 embryonic kidney cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8638-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.943538 SJCRH30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04797 TSC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00875563 BRD-K36031198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03369 HELA BioGPS Cell Line Gene Expression Profiles 1.0 1.06833 BRD-K44139185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14442 BRD-K22280519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83933 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71862 Essential Thrombocytemia_Thrombocyte_GSE2006 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.60635 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.16705 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13234 BRD-K36282114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22587 GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.147 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null other GeneRIF Biological Term Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4714-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3614-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00533399 Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 1.21988 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4637-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF4_01_185 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.92222 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826019 BRD-K29502299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27873 Fatty Liver CTD Gene-Disease Associations 1.0 1.39535 GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.70138 CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00614 SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.9374 SNU308 CCLE Cell Line Gene CNV Profiles -1.0 -2.08783 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18542 BRD-K21718444_KW-2449_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83726 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879619 GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles 1.0 0.875768 NR2F1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-PWCY-2226-SM-2S1OP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986056 GTEX-SE5C-0008-SM-4B64J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09549 GTEX-XBEW-0008-SM-4AT3Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11757 BRD-K05928130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32744 BRD-K92571446_WZ-3105_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K98490050_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PSDG-0226-SM-33HC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.931996 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21471 BRD-A36630025_-666_VCAP_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.30695 CSGALNACT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00763786 Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YARS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00539056 GTEX-XMK1-0126-SM-4B65F GTEx Tissue Sample Gene Expression Profiles 1.0 1.32624 BRD-K07667918_linsitinib_MCF7_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles -1.0 -2.39956 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0083 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17864 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6219-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PB-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.77756 GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles 1.0 1.16573 BRD-K27849471 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.25216 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.115452 KIR3DL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00727503 GTEX-WFG8-1326-SM-4LVN3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.950763 CASP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00461703 8MGBA CCLE Cell Line Gene CNV Profiles -1.0 -1.86389 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MN-01A-22R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61595867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.50533 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17016 PTPA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00841554 BTNL8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550501 U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SHSYSY-RA BioGPS Cell Line Gene Expression Profiles -1.0 -1.22368 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6406-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMAD9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0140891 BRD-A61522392 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48433 Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Psoriasis GWAS Catalog SNP-Phenotype Associations 1.0 1.20529 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles 1.0 0.918843 GTEX-TSE9-3026-SM-3DB76 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972166 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02143 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67398 lupus erythematosus, systemic GAD Gene-Disease Associations 1.0 null GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846159 BRD-K57497543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03865 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19S-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48711 BRD-K90902537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51215 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles 1.0 1.5411 Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58342 BRD-K25731886_-666_NEU_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02190643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17195 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.856073 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.1629 BRD-K60692685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16639 acquired immunodeficiency syndrome; hiv infections GAD Gene-Disease Associations 1.0 null MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.623872 OccipitalLobe BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.979687 BRD-A20213616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0713 GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11831 BRD-K74305673_IMD 0354_MDST8_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO680N CCLE Cell Line Gene Expression Profiles 1.0 1.58397 primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.96189 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9947 BRD-K31758107 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25632 GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890447 globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.862135 BRD-K03489727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68114 BRD-K28347985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96791 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.76653 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.96612 TLR4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00363116 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.3864 GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41886 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32472782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13241 GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles -1.0 -3.40649 ARIH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0069731 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15207 CPCN CCLE Cell Line Gene CNV Profiles 1.0 1.59779 BRD-K28950508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30229 SHC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00725276 STK32C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00738896 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55548 paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22733 pioglitazone_mus musculus_gpl2897_gse8806 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.119879 suggesting GeneRIF Biological Term Annotations 1.0 null BRD-K94442101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42713 hsa-miR-4753-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 PCBP1_02_137 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.16993 MED1_OE_GDS4846_11_human_LNCaP prostate cancer cell GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991769 BRD-K92093830_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 1.14905 SNUC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.59915 GTEX-WFJO-0926-SM-4LVM2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12266 Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMM1 CCLE Cell Line Gene CNV Profiles 1.0 1.53543 Brain Lower Grade Glioma_LGG_TCGA-HT-8563-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-0008-SM-4BOQG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43402 GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles 1.0 0.950275 BRD-K71605668 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28829 Acute Myeloid Leukemia_LAML_TCGA-AB-2865-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833599 icSARS CoV_54Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.902578 hiv-1 GAD Gene-Disease Associations 1.0 null BRD-K61315077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.57637 SZT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00572206 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13236 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.887521 BRD-K31616862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89963 BRD-K83481256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18233 FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-S341-0008-SM-4AD6D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07924 Neural Tube Defects CTD Gene-Disease Associations 1.0 1.02151 GTEX-RU72-0008-SM-46MV8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4208 BRD-K05068331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37367 SUDHL1 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.33343 cognitive disorder GWASdb SNP-Disease Associations 1.0 0.090389 GTEX-X4EO-0926-SM-3P5Z2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.834094 BRD-K53783288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14874 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12345 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50174 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88069 BRD-K21081985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09244 Coma CTD Gene-Disease Associations 1.0 1.13484 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87976 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.86106 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49907 Lung adenocarcinoma_LUAD_TCGA-75-5122-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.36112 RREB1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K49865102_PD-0325901_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPR35 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00589685 GTEX-OXRK-0526-SM-3NB2F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09986 BRD-K96704748_7878890_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.87686 GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07506 GTEX-QLQ7-0008-SM-447AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10634 Hepatitis C, Chronic HuGE Navigator Gene-Phenotype Associations 1.0 null PAX6 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K05804044_AZ-628_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QMR6-1426-SM-32PLA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.823945 HSF1_KD_GDS1733_756_human_HeLa cells - 2 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-A36630025_-666_PC3_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06076 GTEX-RU1J-0008-SM-46MV9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64976 Thyroid peroxidase antibody positivity GWAS Catalog SNP-Phenotype Associations 1.0 0.280662 BRD-K68330990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87083 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940495 Prostate adenocarcinoma_PRAD_TCGA-EJ-8470-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44166 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25305 BRD-K15460257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44076 BRD-K14431723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8819 HCV_8week-No IFN-a_None_GSE37715 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.67113 Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.956376 BRD-A35588707_TENIPOSIDE_VCAP_6.0_h_1.25_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G6PC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00567655 NPHS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00649768 BRD-K68056389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70744 BRD-K26664453_-666_WSUDLCL2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K10089296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.23729 Prostate adenocarcinoma_PRAD_TCGA-J4-A83M-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4520a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16772 BRD-K63887881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41963 BRD-K84775364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23623 type i diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 1.81736 GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles 1.0 0.964521 GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5817 BRD-K74285424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10512 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957161 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.982287 BRD-A02481876_Importazole_MCF7_6.0_h_60.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X4XX-0008-SM-46MVK GTEx Tissue Sample Gene Expression Profiles -1.0 -3.1065 GTEX-QLQW-0126-SM-447BK GTEx Tissue Sample Gene Expression Profiles 1.0 1.26859 BRD-K81575721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41503 BRD-K18385869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03609 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.825441 CHRNB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00580483 16293578-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00685 BRD-K12524155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19488 GTEX-Q2AH-1226-SM-48TZL GTEx Tissue Sample Gene Expression Profiles 1.0 0.939529 Pain CTD Gene-Disease Associations 1.0 1.01099 Nasopharyngeal Neoplasms HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K66187822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23358 Liver Neoplasms HuGE Navigator Gene-Phenotype Associations 1.0 null reactions GeneRIF Biological Term Annotations 1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles 1.0 0.91139 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42492 Memory Disorders CTD Gene-Disease Associations 1.0 1.01966 Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OR5B21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00675987 LOXL2_DEPLETION_GDS4884_88_human_MDA-MB-231 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K69932463_AZD-8055_MCF10A_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K22229373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37016 GTEX-U3ZN-0126-SM-4DXUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.34935 BRD-K07025286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2028 A-Vietnam-1203-2004(H5N1)_3Hour_21865398_GSE28166 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.93216 KARPAS422 CCLE Cell Line Gene Expression Profiles 1.0 1.35326 BRD-K32021110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37933 doxorubicin_homo sapiens_gpl550_gse1647 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Drug-induced liver injury (flucloxacillin) GWAS Catalog SNP-Phenotype Associations 1.0 1.31995 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 2.1612 Brain Lower Grade Glioma_LGG_TCGA-HT-7601-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AKT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00315948 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.47048 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.950035 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles 1.0 1.10279 ITPKB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00562214 GTEX-WH7G-0008-SM-4LVNM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36354 BRD-K85720719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02817 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89366259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14812 cSARS Bat SRBD_36Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.39774 GTEX-OHPN-0008-SM-4E3HW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8658 PPIF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00669938 primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13404 Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21680192_mitoxantrone_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K09819684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14391 BRD-K53417444_OTSSP167_HCC515_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00134 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44264 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-2467-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51179 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.911094 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.921502 hsa-miR-1291 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-K56075657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60969 MMP10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00771338 BRD-K36718828 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33985 middle temporal gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08784 BRD-K33863933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26938 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.855551 BRD-K34482448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71749 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.969798 HCC56 CCLE Cell Line Gene Expression Profiles 1.0 1.58029 KIR3DL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00478953 hsa-miR-1914 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 NF-Y MotifMap Predicted Transcription Factor Targets 1.0 null SP3_01_290 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59309 GTEX-U412-0826-SM-3DB9K GTEx Tissue Sample Gene Expression Profiles 1.0 0.937489 BRD-K48263613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53114 WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46045 SFTPD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00951107 amygdaloid complex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35696 GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles 1.0 1.63202 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AV-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWSA-0926-SM-47JXW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909107 BRD-K81956993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.819 Aflatoxin B1 CTD Gene-Chemical Interactions 1.0 null REST JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K87447060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3144 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5164-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09721 DCANP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00696586 G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.826368 HSP90AA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00417838 BRD-K72452130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.21886 TDO2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00787599 HCC4006 CCLE Cell Line Gene CNV Profiles -1.0 -1.88969 BRD-A88237615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59022 COLO205 BioGPS Cell Line Gene Expression Profiles 1.0 1.271 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11346 BRD-K54948591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11772 GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.9347 GTEX-XPVG-0626-SM-4B65B GTEx Tissue Sample Gene Expression Profiles 1.0 1.15934 SUPHD1 CCLE Cell Line Gene CNV Profiles -1.0 -1.83898 Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37940862_NCGC00185684-02_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ABHD6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00388742 likely GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7410-01A-21R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.33761 GTEX-WEY5-0008-SM-4LMKC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06919 EM2 CCLE Cell Line Gene CNV Profiles 1.0 2.03454 GTEX-W5X1-0526-SM-3GILH GTEx Tissue Sample Gene Expression Profiles 1.0 1.04933 BRD-K54080903 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00608 GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953591 GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56062 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles 1.0 1.29203 GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29173 BRD-K73608149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81762 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.906445 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.83859 BRD-K86797399_pracinostat_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VN-A88O-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78004 Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SBNO2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00394172 angular gyrus, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.872164 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.57077 primary motor cortex (area M1, area 4)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.936862 confirmed GeneRIF Biological Term Annotations 1.0 null BRD-K79555196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14854 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CSRP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00605774 FOS JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-140-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 RUNX1T1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00577929 GTEX-PLZ6-0126-SM-48TC6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47419 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49671 hsa-miR-3652 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.08277 BRD-K48046422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.16515 hsa-miR-3152-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K11242872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.65735 GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46367 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44778 hsa-miR-942 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Lupus Erythematosus, Systemic HuGE Navigator Gene-Phenotype Associations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TD-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50822286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6533 Anemia, Hemolytic CTD Gene-Disease Associations 1.0 1.14816 MAP2K2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00626341 GTEX-W5X1-0008-SM-4LMKA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22225 trioxysalen-5736 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SF172 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 Sarcoma_SARC_TCGA-K1-A6RT-01A-32R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.58836 16643655-1300GenesList GeneSigDB Published Gene Signatures 1.0 null POU5F1_01_42 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.69102 vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.977685 human immunodeficiency virus infectious disease GWASdb SNP-Disease Associations 1.0 2.3549 HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88069 GTEX-OHPL-0008-SM-4E3I9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45908 BTN1A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00560505 TRIM22 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00679556 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null ALDH3A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00629402 GTEX-OXRO-0326-SM-33HBM GTEx Tissue Sample Gene Expression Profiles 1.0 0.848946 BRD-A64091909 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71062 GTEX-R55G-0008-SM-48FEX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79973 GTEX-WYVS-2526-SM-3NMAT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06123 GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00175 OE19 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19657 GMPR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00560251 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58179 A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20176 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20787 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63_01_201 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60216 GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05167 Adenocarcinoma CTD Gene-Disease Associations 1.0 1.04201 confirms GeneRIF Biological Term Annotations 1.0 null IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.968064 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24614 MAP3K5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00589334 BRD-K24387065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62947 L1236 CCLE Cell Line Gene CNV Profiles 1.0 1.47316 BRD-K82126187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85019 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40928 Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.051645 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07668 Lung squamous cell carcinoma_LUSC_TCGA-18-5592-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5022-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null STAT5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00683238 KM12 CCLE Cell Line Gene CNV Profiles -1.0 -1.68222 Lung squamous cell carcinoma_LUSC_TCGA-70-6723-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.948267 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 1.51763 BRD-K57035236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01618 hlab5701 GeneRIF Biological Term Annotations 1.0 null cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.68714 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24243 BRD-A77216878_manumycin A_SKMEL1_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A18419789_Etoposide_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-O5YW-0008-SM-4E3IE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59449 BRD-K38081867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42389 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.834783 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2817-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8074-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976016 relationship GeneRIF Biological Term Annotations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KO-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.15657 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35696 dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.927083 Kidney Chromophobe_KICH_TCGA-KL-8332-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K41327620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11099 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31489 BRD-K93747373_HG-5-113-01_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ITPR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550577 Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K75036062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.24668 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53149 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.08766 BRD-K68548958_-666_SW620_6.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SIGLEC6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00578044 EXO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00677115 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16979 Breast Neoplasms CTD Gene-Disease Associations 1.0 1.12495 Lung squamous cell carcinoma_LUSC_TCGA-39-5036-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20883 disease by infectious agent GWASdb SNP-Disease Associations 1.0 0.687343 hsa-miR-1255a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0586 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5331-01A-02R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-UC-A7PF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28138 BRD-K36324810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62957 BRD-K01699883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10517 BRD-K97798118 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36278 Inflammation CTD Gene-Disease Associations 1.0 1.35098 alleles GeneRIF Biological Term Annotations 1.0 null pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02966 Acquired Immunodeficiency Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K92428232_GSK-461364_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRCA1 JASPAR Predicted Transcription Factor Targets 1.0 null SYNM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00593841 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.35401 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-XMK1-0008-SM-4GICF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941405 BRD-K17675924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80871 GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles 1.0 1.29576 OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.944766 SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.916931 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55271 SW 982 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 0.956343 BRD-K42918627_GSK-2126458_HT29_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7857-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.913986 hsa-miR-769-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 BRD-K89837874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1042 cobalt chloride-454 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PIN1_DEPLETION_GDS4070_450_human_MDA-MB-231 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-4769-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13234 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.27936 HS 895.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27813 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.829386 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.228411 MS4A18 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00675774 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87395 NCIH1563 CCLE Cell Line Gene Expression Profiles 1.0 1.79475 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.60186 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16594 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53525 deferoxamine-mesylate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04291 GTEX-X638-0008-SM-47JZ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0383 BRD-K75961186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03264 GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874734 GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles 1.0 0.826723 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00218 locus GeneRIF Biological Term Annotations 1.0 null ETV1_01_35 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.70586 GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles 1.0 0.846359 PIGW LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00653334 Lung adenocarcinoma_LUAD_TCGA-55-8085-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.376528 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5452-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A07214340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.95402 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29P-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K29642620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25891 HIV Seropositivity HuGE Navigator Gene-Phenotype Associations 1.0 null CDC42SE2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00490704 A-CA-04-2009(H1N1)_18Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.18182 GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.676 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06984 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.57542 TNIP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00793924 revealed GeneRIF Biological Term Annotations 1.0 null BRD-K64857848_XMD-885_MCF7_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A48237631_MITOMYCIN C_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K88395026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05119 BRD-K83183132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.42255 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952568 hsa-miR-150 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 BRD-K96069147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35785 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles 1.0 0.853585 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3455-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles 1.0 0.849324 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.386504 GTEX-WFG8-0008-SM-4LVN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24551 GTEX-R53T-0008-SM-48FEW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23202 RB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00627124 CADOES1 CCLE Cell Line Gene Expression Profiles 1.0 1.53539 nucleotide GeneRIF Biological Term Annotations 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-WOFM-1726-SM-3MJFA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08636 Lung adenocarcinoma_LUAD_TCGA-78-7539-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4779 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 BRD-K50713036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.197 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.977424 single GeneRIF Biological Term Annotations 1.0 null yap1_18413746_mcf10a_gof_human_gpl570_gds3220 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.438679 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K18454119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09026 Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3378-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pregnancy Complications CTD Gene-Disease Associations 1.0 1.17431 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05584 Exanthema CTD Gene-Disease Associations 1.0 1.11325 GTEX-XPVG-0008-SM-4GICH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60275 COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.988621 BRD-K08547377_irinotecan hcl )trihydrate)_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-P4PQ-0008-SM-48TDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23146 BRD-K31273080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19478 GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.70635 BRD-K15300571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29923 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4148-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K36099605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04174 BRD-K11589884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04215 HCC1897 CCLE Cell Line Gene CNV Profiles -1.0 -1.5433 golgi apparatus LOCATE Predicted Protein Localization Annotations 1.0 null skin disease GWASdb SNP-Disease Associations 1.0 0.473064 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03082 GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49538 Fibrosis CTD Gene-Disease Associations 1.0 1.11081 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QA-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892875 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00645 BRD-K49108064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08916 nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.190343 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4798-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-1326-SM-4BRV2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.870365 BRD-M86331534_BJM-ctd2-9_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-M86331534_BJM-ctd2-9_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NAP1L4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00568296 throughout GeneRIF Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUNS1 CCLE Cell Line Gene Expression Profiles 1.0 2.12148 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.46031 hypersensitivity GeneRIF Biological Term Annotations 1.0 null BRD-K24124047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.03151 BRD-K92913067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46863 GTEX-T5JW-0126-SM-4DM6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.12846 GTEX-S3XE-0008-SM-3NM8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09086 PADI1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00573523 CD46 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00838745 BRD-A89067742_HTS 10765_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4440 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 BRD-A48237631_MITOMYCIN C_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A-CA-04-2009(H1N1)_36Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.71652 Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03217 GTEX-WFG7-1526-SM-4LVMG GTEx Tissue Sample Gene Expression Profiles 1.0 0.914928 BRD-K10182289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50039 GTEX-R55C-0008-SM-48FCF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16027 BRD-A57474391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7677 AGTR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00466001 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null EB2 CCLE Cell Line Gene Expression Profiles 1.0 1.52179 BRD-K49865102_PD-0325901_HEPG2_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-3656 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 L1CAM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00637537 hsa-miR-490-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 simple GeneRIF Biological Term Annotations 1.0 null BRD-K05649647_-666_COV644_6.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.890637 Hyperplasia CTD Gene-Disease Associations 1.0 1.42321 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15998 Lung adenocarcinoma_LUAD_TCGA-05-4250-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00700348 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles 1.0 1.82407 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948428 BRD-K18190982_COT-10b_VCAP_6.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null critical GeneRIF Biological Term Annotations 1.0 null hsa-miR-4760-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 necrolysis GeneRIF Biological Term Annotations 1.0 null inflammatory abnormality of the skin GWASdb SNP-Phenotype Associations 1.0 0.879094 BRD-K67856917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00628 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VM-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 59M CCLE Cell Line Gene Expression Profiles 1.0 1.5854 BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_NCIH2073_6.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sample GeneRIF Biological Term Annotations 1.0 null BRD-K81120201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04008 BRD-K79807180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27802 BRD-K86694287 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24606 HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MAP4K3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00612219 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.43797 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K64264170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88235 SDK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00567295 BRD-K49865102_PD-0325901_HT29_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.631989 TOB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00702239 mozambique GeneRIF Biological Term Annotations 1.0 null Arthritis, Psoriatic HuGE Navigator Gene-Phenotype Associations 1.0 null outer CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10861 BRD-K12325488 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17228 caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04813 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.927833 Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K26231789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14042 Dhori Virus_48Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.40919 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K55218521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49583 BRD-A47109850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62828 GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1126 BRD-K73001304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6401 Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-0526-SM-4DXTK GTEx Tissue Sample Gene Expression Profiles 1.0 1.19936 BRD-K16279128 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09589 SARS-BatSRBD_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.8194 RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05584 Prostate adenocarcinoma_PRAD_TCGA-HC-8266-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MIR221_KD_GDS4054_455_human_MCF7 breast cancer cells (fulvestrant-resistant) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-A76904477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39278 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892439 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52592505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33564 BRD-K25600773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61009 BRD-K01922054 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03663 19658189-TableS4 GeneSigDB Published Gene Signatures 1.0 null cochlear nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18416 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.5021 BRD-K00909602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.52536 GTEX-W5WG-2226-SM-4LMI3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02619 Anemia CTD Gene-Disease Associations 1.0 1.02783 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A819-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 1.83064 BRD-K05563014_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RUSQ-0326-SM-47JWS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936937 BRD-K37763427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0648 GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles 1.0 0.980569 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11487 REL JASPAR Predicted Transcription Factor Targets 1.0 null KYAT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00901006 gracile nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05261 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBED-0008-SM-47JWO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21267 BRD-K00900096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51343 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.981247 Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K48020855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02923 SUPB15 CCLE Cell Line Gene Expression Profiles 1.0 1.50961 ANGPTL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0060082 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64895 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19M-06A-61R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82433264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04292 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867692 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13347 mexican GeneRIF Biological Term Annotations 1.0 null MRTFA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00518942 BRD-K17474512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30924 Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Epidermal Necrolysis, Toxic HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K99252563_QL-XII-47_MCF10A_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955968 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01365 HIPK2_defectivemutant_29_GDS4233 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.82461 GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46788 BRD-A81392774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51084 GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles 1.0 1.35224 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.76867 BRD-K49404994_levetiracetam_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K94512704_-666_NEU_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18033 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.11856 organelle LOCATE Predicted Protein Localization Annotations 1.0 null principal sensory nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.72495 HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03547 BRD-K60507129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10633 HPRT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00361381 TNFRSF10C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00613278 GTEX-POMQ-0126-SM-48TD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.46024 ADO LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00627217 17312329-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GTEX-T5JC-0226-SM-32PMA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03166 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.13758 GTEX-XV7Q-0126-SM-4BRVK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18206 BRD-K57228212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41566 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4640-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44865 hsa-miR-4430 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Drug Toxicity HuGE Navigator Gene-Phenotype Associations 1.0 null complete GeneRIF Biological Term Annotations 1.0 null GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20887 genetic GeneRIF Biological Term Annotations 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8326-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66818 GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.93135 GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.51521 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.91483 SLC38A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00477745 GTEX-TML8-0008-SM-4DXUI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54314 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890495 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GT-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19688 GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02182 GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12478 GIMAP5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00517794 16651414-Supp4 GeneSigDB Published Gene Signatures 1.0 null CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null control GeneRIF Biological Term Annotations 1.0 null BRD-K75779523 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57555 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15829 GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17606 BRD-K99681648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10923 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41571 BRD-K50603336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.465 BRD-K65440031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1737 abnormality of the skin GWASdb SNP-Phenotype Associations 1.0 0.338738 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.28549 GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 2.18641 Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K81418486_vorinostat_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles 1.0 1.09173 BRD-K37760996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99518 Kidney Diseases CTD Gene-Disease Associations 1.0 1.16434 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3I6-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00692939 GTEX-TSE9-0011-R10A-SM-3DB7O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893082 GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.56018 Adrenocortical carcinoma_ACC_TCGA-OR-A5LM-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3188 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20915 BRD-K66735566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33335 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.05931 GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839074 BRD-K39159284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7168 BRD-K18076490 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0146 GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 1.34939 BRD-K47348275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35344 BRD-K40116023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.77948 GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81653 ELK4 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09753 GTEX-T6MN-0826-SM-32PM4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.951361 GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.09503 Lung adenocarcinoma_LUAD_TCGA-86-8671-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null behcet's disease GWASdb SNP-Disease Associations 1.0 1.54476 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.976969 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02846 BRD-K92991072_PAC 1_MDST8_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.895715 BRD-K19946529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.22665 18698033-tableS1-STAT1 GeneSigDB Published Gene Signatures 1.0 null TP53BP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00524284 hsa-miR-1237 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.44845 ATP5F1D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00623986 floxacillin GAD Gene-Disease Associations 1.0 null GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 1.05911 BRD-K56942203 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10292 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8221 BRD-K69932463_AZD-8055_HME1_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-5126-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.13211 GTEX-X5EB-2626-SM-4E3HZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23385 GTEX-TMZS-0008-SM-47JWM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11464 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49907 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.852856 BRD-A09719808_NCGC00188536-01_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FEV JASPAR Predicted Transcription Factor Targets 1.0 null HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.74884 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20176 BRD-K49865102_PD-0325901_HEPG2_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.34268 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.74313 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51364 RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4654 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 SW1990 CCLE Cell Line Gene CNV Profiles 1.0 2.44337 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.91105 Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U138 BioGPS Cell Line Gene Expression Profiles -1.0 -1.18518 SNU1214 CCLE Cell Line Gene CNV Profiles -1.0 -1.71035 HUPT3 CCLE Cell Line Gene CNV Profiles 1.0 2.46149 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MM-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HINT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556195 BRD-K82818427_Chemistry 1735_HT29_24.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K72335238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22414 GTEX-XBEC-0008-SM-4AT3X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35905 GTEX-XLM4-0008-SM-4AT4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35965 Kidney Chromophobe_KICH_TCGA-KL-8343-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K27726273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00828 SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0198 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46586 all GWASdb SNP-Phenotype Associations 1.0 0.118898 BRD-A25775766_Securinine_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-4704-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.979936 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10629 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01107 BRD-K48860650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.7134 BRD-K37764012_PF-3758309_MCF7_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.86287 BRD-K57080016_selumetinib_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.929828 BRD-K50000283_PHA-767491_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null type 1 diabetes mellitus GWASdb SNP-Disease Associations 1.0 1.8787 hsa-miR-4688 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HU-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A56345662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03648 schizophrenia GWASdb SNP-Disease Associations 1.0 0.526676 observed GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A87C-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.230696 BRD-K84706257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90003 hsa-miR-4697-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00385 BRD-K83902026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23468 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.69995 CHIT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00706476 inferior temporal gyrus, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.938991 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.999958 GTEX-POMQ-0826-SM-3P61H GTEx Tissue Sample Gene Expression Profiles 1.0 1.00805 SARS-BatSRBD_72Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.47609 CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35745 BRD-K53293966 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04599 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K88070218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47845 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 0.924699 GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.28468 BRD-K36465335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03666 BRD-A06837695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6497 BRD-A26165232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02998 BRD-K09854848_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K43896262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56382 BRD-K64860662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.25348 A-CA-04-2009(H1N1)_36Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.22574 SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Atherosclerosis CTD Gene-Disease Associations 1.0 1.10562 abnormality of macrophages GWASdb SNP-Phenotype Associations 1.0 0.396722 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4888-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.896161 CCL3L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00673612 Heart Failure dbGAP Gene-Trait Associations 1.0 0.008777 psychotic disorder GWASdb SNP-Disease Associations 1.0 0.2361 BRD-K70198986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40052 BRD-K49865102_PD-0325901_HT29_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54G-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spleen GTEx Tissue Gene Expression Profiles 1.0 1.70528 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67961 hsa-miR-3677-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.27107 Prostate adenocarcinoma_PRAD_TCGA-CH-5745-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10938308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29823 EHEB CCLE Cell Line Gene Expression Profiles 1.0 2.43424 prevalent GeneRIF Biological Term Annotations 1.0 null GTEX-WFG8-0126-SM-4LVMH GTEx Tissue Sample Gene Expression Profiles 1.0 0.84746 COR-L26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.94914 BRD-K64862097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07752 rara_21299862_mcf7_lof_human__gds4065 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.152018 susceptibility GeneRIF Biological Term Annotations 1.0 null GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.46934 GTEX-XAJ8-0526-SM-47JYK GTEx Tissue Sample Gene Expression Profiles 1.0 0.858302 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.60919 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ABL1_mutant_179_GSE45452 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.43179 BRD-K91973560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07736 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19239 Prostate adenocarcinoma_PRAD_TCGA-VP-A87E-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.883715 GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83941 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04657 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899548 STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2688 hsa-miR-619 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05524 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.668836 NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.91333 GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles 1.0 1.04006 HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.895025 Lung squamous cell carcinoma_LUSC_TCGA-18-3415-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12114 BRD-K82194980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91355 BRD-K44692299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15438 Sarcoma_SARC_TCGA-HS-A5N7-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.16551 NHLH1 JASPAR Predicted Transcription Factor Targets 1.0 null FEN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00738742 BRD-K02073410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4173 SNU1077 CCLE Cell Line Gene CNV Profiles 1.0 1.45371 vasculitis GWASdb SNP-Disease Associations 1.0 0.523346 disease GWASdb SNP-Disease Associations 1.0 0.157719 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IS-01A-21R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-0008-SM-4BRW6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3804 A-CA-04-2009(H1N1)_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.09695 BRD-K68086276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35292 PPARD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00345025 diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.572823 BRD-K65774385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43332 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.45987 F5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00546377 primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22056 BRD-K20285085_R406_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GJC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00537889 BRD-A90643929_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41025232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10674 GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69847 Sarcoma_SARC_TCGA-3B-A9HQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Drug Hypersensitivity HuGE Navigator Gene-Phenotype Associations 1.0 null abacavir GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDVN-0008-SM-48U2D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32514 GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 1.31132 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WW-01A-22R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40175214_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null precuneus, right, superior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.850315 abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.138072 BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_VCAP_6.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A820-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K58307544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69698 ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01339 EJM CCLE Cell Line Gene CNV Profiles 1.0 1.68844 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04156 Lung adenocarcinoma_LUAD_TCGA-44-2668-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68006 BRD-K49490091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28005 GTEX-VUSH-0008-SM-47JWK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28851 glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.52854 Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.140022 hsa-miR-4645-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 TNFRSF10B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00831385 GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 1.41896 BRD-K93283197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35606 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11683 hsa-miR-4784 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1454 MAFK_02_183 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65208 BRD-K82839033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41018 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871131 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4346-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4771-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SR BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00649 GBP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00507667 GTEX-T6MN-0008-SM-4DM7H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49226 MDAMB231 CCLE Cell Line Gene CNV Profiles 1.0 1.41793 BRD-K81473043_-666_MDST8_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5630-01A-01R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00495473 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4099-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-CA-04-2009(H1N1)_30Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.36451 SCN7A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00577033 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23922 due GeneRIF Biological Term Annotations 1.0 null LYPD6B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00600577 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.960336 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6779-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02943 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.59681 BRD-A30758703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64896 GTEX-QCQG-0526-SM-48U2A GTEx Tissue Sample Gene Expression Profiles 1.0 1.38283 EHBP1L1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00970561 BRD-K81471597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13211 SP in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22163 GTEX-QMRM-0008-SM-447B1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38605 GTEX-WRHU-0006-SM-3MJF6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4177 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18866 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61929 anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.995609 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22691 BRD-K37680172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16428 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25006 HRAS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0042659 BRD-K95153342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63976 Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13681383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09094 Brain Diseases CTD Gene-Disease Associations 1.0 1.08513 GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.835811 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879619 BRD-K94469522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53919 SW1990 COSMIC Cell Line Gene CNV Profiles 1.0 2.15316 16434974-Table1 GeneSigDB Published Gene Signatures 1.0 null psoriasis GWASdb SNP-Phenotype Associations 1.0 2.13087 BRD-K26766324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44325 principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22267 BRD-K78400597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20667 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.26184 GTEX-UJHI-0126-SM-4IHLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.57911 hsa-miR-4792 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.88793 ventrolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.972218 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13234 gastrointestinal system disease GWASdb SNP-Disease Associations 1.0 0.363792 GTEX-XXEK-0008-SM-4BRW7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6061 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73F-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10781609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14334 BRD-K17175263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18895 MZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13812 BRD-K82764092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72524 BRD-A48237631_MITOMYCIN C_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null Neoplasms CTD Gene-Disease Associations 1.0 1.44382 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.91881 MYB_01_48 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.25758 GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.44934 Hypertrophy CTD Gene-Disease Associations 1.0 1.02746 BRD-K44492160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26936 NKX3-1 JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-589 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 SORL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00712546 RS11846 BioGPS Cell Line Gene Expression Profiles 1.0 1.67882 abnormality of the abdomen GWASdb SNP-Phenotype Associations 1.0 0.279251 BRD-K46739745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0683 HIV-1 control GWAS Catalog SNP-Phenotype Associations 1.0 1.34627 NCIH1092 CCLE Cell Line Gene CNV Profiles -1.0 -1.3561 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K03902789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03494 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10386 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XK-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K96416345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.96087 hsa-miR-4701-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 BRD-A46566149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55178 TYMS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00527104 GTEX-S4Q7-0003-SM-3NM8M GTEx Tissue Sample Gene Expression Profiles 1.0 1.74365 GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3059 OCI-LY-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13858 GTEX-R55D-0008-SM-48FEV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37032 BRD-K27870441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51436 HNT-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.880071 BRD-K19418944 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71242 Urinary Bladder Neoplasms CTD Gene-Disease Associations 1.0 1.40457 GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37104 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 1.14339 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null BRD-K99172965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.75458 GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894899 GTEX-S95S-0008-SM-4AT5M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18752 BRD-A89846380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35461 GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63497 orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10078 SBK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00554951 JHESOAD1 CCLE Cell Line Gene CNV Profiles 1.0 1.89325 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869094 BRD-K49865102_PD-0325901_HT29_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAPK8IP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00549483 ADAMDEC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0055739 acquired immunodeficiency syndrome GAD Gene-Disease Associations 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.14514 MS4A6A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00586507 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61895 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88273 abnormality of skin physiology GWASdb SNP-Phenotype Associations 1.0 0.879094 Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADH7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0044739 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24121 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88069 LOXL2_KD_GSE35600_688_human_MDA-MB-231 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K11003742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56402 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39367 DUSP7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00612792 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.278736 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null hlac GeneRIF Biological Term Annotations 1.0 null GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 1.46739 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36045 OFD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00596083 GTEX-R45C-0008-SM-48FF2 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.11957 Lung squamous cell carcinoma_LUSC_TCGA-68-A59J-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00565139 GTEX-XV7Q-0626-SM-4BRV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927477 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5329-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06792661_Narciclasine_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18541 BRD-K75143842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06915 vascular disease GWASdb SNP-Disease Associations 1.0 0.162041 BRD-K03213425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36814 BRD-K49865102_PD-0325901_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K46924722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29571 GTEX-PLZ4-0008-SM-48TE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22955 HT1376 CCLE Cell Line Gene CNV Profiles 1.0 1.99652 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.06928 cycle GeneRIF Biological Term Annotations 1.0 null PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.942248 BRD-K09720842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.1521 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16279 abnormality of the liver GWASdb SNP-Phenotype Associations 1.0 2.29851 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.881008 BRD-K64902833 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.39843 Lung adenocarcinoma_LUAD_TCGA-44-2657-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09721 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50809 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.26832 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.98898 ncoa_22072566_ly2_lof_human_gpl570_gds4095 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 2.22133 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981201 BRD-K21025364_NVP-TAE226_HT29_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.927647 BRD4_01_311 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.15155 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles 1.0 0.830898 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1597 Hypersensitivity HuGE Navigator Gene-Phenotype Associations 1.0 null Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83751422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7829 BRD-K06569345_HG-5-88-01_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4713-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827043 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ccr5 GeneRIF Biological Term Annotations 1.0 null GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 0.83674 BRD-K34234678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.90409 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GO-06A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K87712055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08287 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.880982 schizophrenia GWASdb SNP-Phenotype Associations 1.0 0.449262 GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998697 BRD-K55399138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47781 set GeneRIF Biological Term Annotations 1.0 null hsa-miR-3150b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893993 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48879 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1665 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45919 DNASE1L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00641067 icSARS CoV_72Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.11619 SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.968251 GTEX-OXRK-1726-SM-3NB16 GTEx Tissue Sample Gene Expression Profiles 1.0 0.98524 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843517 granulomatosis GWASdb SNP-Phenotype Associations 1.0 0.446423 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -1.13002 Kidney Chromophobe_KICH_TCGA-KO-8413-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.29991 Brain Lower Grade Glioma_LGG_TCGA-HT-8106-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Amygdala BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.874114 Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 1.3793 GTEX-RWSA-0526-SM-2XCBC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860324 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.979936 Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K75539052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25266 SUDHL6 CCLE Cell Line Gene CNV Profiles 1.0 1.80341 FUT8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00521409 PLA1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00666764 GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33964 BRD-K41451401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70642 GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 0.853984 GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960121 BRD-K03093950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20801 BRD-K18856772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01056 MJ CCLE Cell Line Gene Expression Profiles 1.0 1.6545 BRD-K74514084_pazopanib_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-P4QS-0008-SM-48TDY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31934 G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K49865102_PD-0325901_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08177 TUBB6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0051314 OVCAR8 BioGPS Cell Line Gene Expression Profiles 1.0 0.857093 BRD-K06243138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.156 haplotype GeneRIF Biological Term Annotations 1.0 null BRD-K93051667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06579 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.827838 FOXO3 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13858 HCMV_24Hour_20173022_GSE17948 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.33045 Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEL4-0008-SM-447AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20175 BRD-K25536815_-666_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K36164005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28077 abnormality of cellular immune system GWASdb SNP-Phenotype Associations 1.0 0.193319 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.32905 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K76088420 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0225 GTEX-PW2O-1926-SM-2S1OB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928093 GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857646 BRD-K12683022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9608 NFIC JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-TSE9-0008-SM-4DXT8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57975 Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCAM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00562387 GTEX-U3ZH-0626-SM-4DXT3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876332 BRD-K39584933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3613 BRD-K68174511_-666_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K19457629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5628 MKN7 CCLE Cell Line Gene CNV Profiles -1.0 -2.34526 acquired immunodeficiency syndrome GWASdb SNP-Disease Associations 1.0 1.97455 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I1-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 1.4818 GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles 1.0 1.14372 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles 1.0 0.936956 BRD-K25177502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03972 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.36991 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.945432 GTEX-U412-0008-SM-4DXTE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18057 BRD-K18601936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30495 Lung adenocarcinoma_LUAD_TCGA-83-5908-01A-21R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00638935 BRD-K29458283_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.03235 GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.37984 cSARS Bat SRBD_60Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.2732 BRD-K31342827_GF 109203X_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31868 FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7415-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1255b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 mRNA_POU5F1_20526341 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K59544784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1699 Bladder Urothelial Carcinoma_BLCA_TCGA-LC-A66R-01A-41R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60188481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20791 BRD-K17232330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74728 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06042 GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 1.72446 GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08451 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.983127 Premature aging_Skin fibroblast_GSE10123 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.06678 RERFLCAD1 CCLE Cell Line Gene CNV Profiles 1.0 1.66273 genotyping GeneRIF Biological Term Annotations 1.0 null BRD-K61278167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32054 BRD-K79748109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39794 BRD-K42526449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06746 AQP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00737828 MYDGF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00816128 BRD-K06310280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06798 Floxacillin dbGAP Gene-Trait Associations 1.0 1.71999 GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839634 BRD-K89328601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07091 BRD-K10784927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27548 BRD-K78245984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29474 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.935584 BRD-K05649647_-666_HCC515_6.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K27287379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2301 OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.38975 hsa-miR-548s TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AG-0011-R3A-SM-2HMJ9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908626 STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null SETD1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0046143 BRD-K04462989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38274 hsa-miR-1343 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 whether GeneRIF Biological Term Annotations 1.0 null A-VN-1203-2004(H5N1)_Day2-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.82794 BRD-K81960205 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55969 Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K59491389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04319 BRD-K09951645_dabrafenib_HT29_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null reticular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43198 19061838-TableS7 GeneSigDB Published Gene Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3924-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null USF1 JASPAR Predicted Transcription Factor Targets 1.0 null TNFSF13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00530965 imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T2IS-1026-SM-32QP1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830732 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.19499 BRD-A75087829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55784 SRF JASPAR Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.860516 TFAP2C_01_312 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.58576 red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08996 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18758 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18837 trovafloxacin_homo sapiens_gpl96_gse9166 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K22508525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.62344 influence GeneRIF Biological Term Annotations 1.0 null ITGA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00534039 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958103 COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13347 CSNK2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00397783 supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.90784 BRD-A79768653_sirolimus_H1299_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18599 ASNS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00345481 BRD-K23835343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07496 SIRT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00341013 Lung squamous cell carcinoma_LUSC_TCGA-22-5474-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null treated GeneRIF Biological Term Annotations 1.0 null STK17B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0050172 BRD-K41655405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.66365 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08682 IRF1 JASPAR Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00639314 psoriasis GWASdb SNP-Disease Associations 1.0 2.18136 GTEX-X4EP-0626-SM-3P621 GTEx Tissue Sample Gene Expression Profiles 1.0 0.862779 BRD-K06500446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81016 GTEX-T8EM-1226-SM-4DM5J GTEx Tissue Sample Gene Expression Profiles 1.0 0.875029 BRD-K47983010_BX-795_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10526 BRD-K82868643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36039 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JT-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRIN3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00694541 GTEX-X4XY-0526-SM-46MW1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995183 Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A2PC-01A-11R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00752 load GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61S-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSTK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0060767 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.87209 BRD-K25039453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42553 BRD-K08730634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01747 P31FUJ CCLE Cell Line Gene CNV Profiles -1.0 -1.47186 AR ChEA Transcription Factor Targets 1.0 null GTEX-U3ZH-0008-SM-4DXT2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.13177 BRD-K61022988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33292 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIFR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00556724 BRD-K07313741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27127 BRD-K73604422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.69346 NCF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00475441 BRD-K46155894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01997 KASUMI1 CCLE Cell Line Gene CNV Profiles -1.0 -1.40922 Hypothalamus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2892 allele GeneRIF Biological Term Annotations 1.0 null BRD-A36630025_-666_SNUC4_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A34806832_Proscillaridin A_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles 1.0 0.854293 BRD-K26122955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14409 Necrosis CTD Gene-Disease Associations 1.0 1.70265 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.879191 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.48093 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-U08759356_EI-346_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WDR87 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00669577 liver disease GWASdb SNP-Disease Associations 1.0 1.4259 homosalate-3797 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null spontaneous GeneRIF Biological Term Annotations 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05071 Leprosy HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K62650632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89588 GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 1.56193 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.829386 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39427 MUTZ5 CCLE Cell Line Gene Expression Profiles 1.0 1.58986 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37104 BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_DV90_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-Q734-0226-SM-48U1A GTEx Tissue Sample Gene Expression Profiles 1.0 1.17788 F10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00450647 MADCAM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00727648 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04151 RV16_0Hour-B2B_None_GSE28904 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.80324 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09602 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881408 Liver hepatocellular carcinoma_LIHC_TCGA-2V-A95S-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2869-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Asthma CTD Gene-Disease Associations 1.0 1.08301 BRD-K18139667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13329 BRD-K75840180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14416 GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00563 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.5615 GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22599 BRD-K09191014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05219 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A3X6-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ROBO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00484682 E2A MotifMap Predicted Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.02042 icSARS CoV_60Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.24178 GTEX-S3XE-0626-SM-4AD6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.16364 ZNRF3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00616357 GTEX-S7SE-0926-SM-2XCD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19591 BRD-K05496005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00361 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.895646 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939166 BRD-A63894585_Clobetasol propionate_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K05128360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.4188 BRD-K72414522_AZD-5438_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K95921201_RESERPINE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K21680192_mitoxantrone_A549_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42486632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19945 BRD-K65932559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15991 Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60052521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25139 ITGAL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00592238 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03775 GTEX-T2IS-0008-SM-4DM75 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29034 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD4+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.37085 cuneus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24848 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.990266 BRD-A22502289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09419 BRD-K31806725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84444 GTEX-X5EB-0008-SM-46MU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37704 Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FGF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00480553 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.871734 GTEX-Q2AG-0526-SM-2S1PW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11434 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.051838 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22505 NCIH1395 CCLE Cell Line Gene Expression Profiles 1.0 2.19084 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles 1.0 0.85087 GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865242 heart failure GAD Gene-Disease Associations 1.0 null drug-induced hepatitis GWASdb SNP-Disease Associations 1.0 2.31741 GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53969 BRD-K35693854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74101 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.64492 BRD-K98490050_AMSACRINE_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPI-PLD_OE_GDS2049_176_human_Hepatoma HepG2 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K28790383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.66421 BRD-A07870296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41165 Lung adenocarcinoma_LUAD_TCGA-50-5941-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K81888673 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48923 ESR1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K61681480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4904 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11084 abnormality of leukocytes GWASdb SNP-Phenotype Associations 1.0 0.193319 BRD-K97805186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1876 BRD-K08300592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96035 COLEC11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00631141 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29471 BRD-K03191078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0949 chronic GeneRIF Biological Term Annotations 1.0 null GTEX-WH7G-1626-SM-4LVMY GTEx Tissue Sample Gene Expression Profiles 1.0 0.898027 GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54763 BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_WSUDLCL2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TAF1L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00710908 SNU1197 CCLE Cell Line Gene CNV Profiles -1.0 -1.3976 GTEX-X4XY-1026-SM-46MVX GTEx Tissue Sample Gene Expression Profiles 1.0 0.91755 inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.996338 BRD-K99311962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04859 HIV Infections HuGE Navigator Gene-Phenotype Associations 1.0 null JUND JASPAR Predicted Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GJ-01A-21R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GJB6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00616629 BRD-K95575699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17073 GTEX-WYVS-0526-SM-3NM9W GTEx Tissue Sample Gene Expression Profiles 1.0 0.93901 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28322 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.51531 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09852 Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K08036779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14922 Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.26732 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32772 BRD-K26620362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.76267 BRD-K25718133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73319 MTCH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00821388 TIAM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00588296 GTEX-VJYA-0126-SM-4KL1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.44202 GTEX-XAJ8-0126-SM-47JYG GTEx Tissue Sample Gene Expression Profiles 1.0 1.44502 hepatitis GWASdb SNP-Disease Associations 1.0 1.88019 GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25178 BRD-K85907501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17829 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47777 hsa-miR-2355-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 hsa-miR-4518 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-U3ZN-0008-SM-4DXTL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12279 BRD-K34026318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67932 increases GeneRIF Biological Term Annotations 1.0 null hsa-miR-1273f TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 BRD-K60758969 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26146 GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.861147 striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17309 WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.89467 stratum pyramidale of rostral CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.921416 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A35588707_TENIPOSIDE_VCAP_24.0_h_1.25_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-M86331534_BJM-ctd2-9_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.904374 COLO792 CCLE Cell Line Gene CNV Profiles 1.0 1.33679 HLF JASPAR Predicted Transcription Factor Targets 1.0 null GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63193 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57184 Sarcoma_SARC_TCGA-DX-A7EL-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07283 BRD-K47801291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28628 region GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-6851-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.844777 population GeneRIF Biological Term Annotations 1.0 null GTEX-XV7Q-0008-SM-4BRWL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34557 assessed GeneRIF Biological Term Annotations 1.0 null NQO2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00738086 Vascular Diseases CTD Gene-Disease Associations 1.0 1.39338 GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14142 Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLA2G2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00590694 16651414-Supp3 GeneSigDB Published Gene Signatures 1.0 null Dysuria CTD Gene-Disease Associations 1.0 1.02708 AP5B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00581437 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66445 demonstrate GeneRIF Biological Term Annotations 1.0 null DLAT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00606798 GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.61004 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1373 SLC44A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00692517 JVM2 CCLE Cell Line Gene Expression Profiles 1.0 1.71612 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.50458 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.979936 J82 CCLE Cell Line Gene CNV Profiles 1.0 1.74735 anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1954 BRD-K49865102_PD-0325901_HEPG2_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ID1_01_117 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.06648 clarify GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KA-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null KCNA7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00746859 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886423 GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 2.06606 GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.6771 hepatic granulomatosis GWASdb SNP-Phenotype Associations 1.0 1.39971 BRD-K26552461 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38223 Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Drug Hypersensitivity CTD Gene-Disease Associations 1.0 1.04574 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29384 TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917808 gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.089608 Lung adenocarcinoma_LUAD_TCGA-73-4666-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null variant GeneRIF Biological Term Annotations 1.0 null BRD-K02078984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22349 PDE8A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00479382 SEMA4C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00794979 hsa-miR-4650-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00077 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.876786 GTEX-WK11-0526-SM-3NB3O GTEx Tissue Sample Gene Expression Profiles 1.0 0.99898 GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.70408 JUN JASPAR Predicted Transcription Factor Targets 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null small intestine GTEx Tissue Gene Expression Profiles 1.0 0.83149 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles 1.0 0.949217 NFYA JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K43159427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.32484 fenbufen-3721 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.312808 BRD-K55479099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89542 BRD-K16733272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.54658 GTEX-PWOO-2426-SM-2S1OV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.924682 Lung Neoplasms CTD Gene-Disease Associations 1.0 1.4275 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A44A-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55093 BRD-K22420708 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17697 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1871 HCC1419 CCLE Cell Line Gene CNV Profiles 1.0 1.70444 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.893785 GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870145 superior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.851186 hsa-miR-595 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 ANXA5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00434255 GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles 1.0 1.11154 GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896852 rs2395029g GeneRIF Biological Term Annotations 1.0 null hsa-miR-3127-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.04611 BRD-K98490050_AMSACRINE_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K49075727_nintedanib_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03121 ZFX_KD_GSE43021_130_human_NOMO1 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.44467 GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44463 BRD-K83832060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44497 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14026 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.921068 KP4 CCLE Cell Line Gene CNV Profiles -1.0 -2.20613 A-CA-04-2009(H1N1)_48Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.82686 GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894378 Mesothelioma_MESO_TCGA-MQ-A6BQ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSK3B_knockdown_204_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.44466 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K54606188_(+)-JQ1_PC3_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K59369769_tozasertib_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S33H-0008-SM-4AD6C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13991 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K45028867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39084 GTEX-XOT4-0008-SM-4B664 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11593 GTEX-XXEK-0126-SM-4BRVU GTEx Tissue Sample Gene Expression Profiles 1.0 1.70396 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GU-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62325456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00042 BRD-A09349126_NORETHINDRONE ACETATE_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 1.98999 GTEX-U8XE-0008-SM-4E3K4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44391 COX7C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00830739 Cholestasis CTD Gene-Disease Associations 1.0 1.01437 GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860328 MAP3K12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599005 SARS-CoV_60Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.23818 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44245 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6954-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K69093885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06687 hsa-miR-4758-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 BRD-K45367466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22417 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.35639 BRD-A34205397_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SFRP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00548997 hypersensitivity GAD Gene-Disease Associations 1.0 null CDH11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00668473 ZNF354C JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K67096761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39099 mestizos GeneRIF Biological Term Annotations 1.0 null GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78591 SOX9 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K83846772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49117 GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84723 OR2L13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00833059 FOSL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00756537 BRD-K62460895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36919 alpha-CP1 MotifMap Predicted Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78P-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WTAP_KD_GDS2010_69_human_HUVEC (umbilical vein endothelial cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.836568 GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01336 BRD-K81144230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17214 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles 1.0 0.979612 subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26138 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles 1.0 0.857589 BRD-A36630025_-666_HT29_24.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K36855468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09197 markers GeneRIF Biological Term Annotations 1.0 null STAT1_01_154 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.92505 BRD-U61997977_WZ-4-145_HA1E_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SKM1 CCLE Cell Line Gene Expression Profiles 1.0 1.68265 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92859 PTPN14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00625289 FOXP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00508467 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.947132 hsa-miR-4757-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Acquired Immunodeficiency Syndrome dbGAP Gene-Trait Associations 1.0 1.36815 Stevens-Johnson Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A0TN-01A-21R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.931003 Mesothelioma_MESO_TCGA-LK-A4O5-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A19037878_trichostatin A_PHH_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles 1.0 1.07188 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q7-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4673 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 BRD-K33805195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55839 Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC78 CCLE Cell Line Gene Expression Profiles 1.0 1.71044 hsa-miR-3130-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SF1_01_146 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58773 abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.099708 GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles 1.0 1.07238 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930676 Carcinoma CTD Gene-Disease Associations 1.0 1.03678 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8221 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98529 UBE2N LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497736 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 1.23994 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06234 ADCK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00474458 integumentary system disease GWASdb SNP-Disease Associations 1.0 0.436575 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acquired immunodeficiency syndrome; hiv seropositivity GAD Gene-Disease Associations 1.0 null BRD-K13662825_dinaciclib_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29206 generalized abnormality of skin GWASdb SNP-Phenotype Associations 1.0 0.375137 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles 1.0 1.11678 Hepatitis C HuGE Navigator Gene-Phenotype Associations 1.0 null SHSYSY+RA BioGPS Cell Line Gene Expression Profiles -1.0 -1.12404 PBX1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K42145213 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84982 BRD-K79982586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87637 Rectum adenocarcinoma_READ_TCGA-AF-3911-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2865 BRD-K20009653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22459 BRD-K41513047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12526 GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles 1.0 1.76261 GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91611 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WX-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GART LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00759978 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.53279 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles 1.0 1.2425 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41122 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96325 points GeneRIF Biological Term Annotations 1.0 null GTEX-WFG7-0008-SM-4LMKB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15942 GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 1.74671 alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K96096022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86023 syndrometoxic GeneRIF Biological Term Annotations 1.0 null dorsolateral prefrontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.878714 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.05404 HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88069 disease of mental health GWASdb SNP-Disease Associations 1.0 0.04128 SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.692313 BRD-K79259477_KIN001-265_HEPG2_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null serve GeneRIF Biological Term Annotations 1.0 null BRD-K15108141_gemcitabine_PC3_24.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K37890730_Camptothecine (S,+)_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Behcet Syndrome dbGAP Gene-Trait Associations 1.0 1.03781 aids progression GAD Gene-Disease Associations 1.0 null GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.56727 BRD-K89260735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00832 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13379 TNFSF13B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0106408 BRD-K87875370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41841 CEBPB JASPAR Predicted Transcription Factor Targets 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01472 GTEX-NL3H-0011-R3a-SM-2I3GL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875146 Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A61P-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prediction GeneRIF Biological Term Annotations 1.0 null GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59058 GTEX-P4PP-0926-SM-48TBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.26722 CCRF-SB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.76647 BRD-K21680192_mitoxantrone_SKBR3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null brain GTEx Tissue Gene Expression Profiles -1.0 -1.06894 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54D-01A-21R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31939603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07869 restriction GeneRIF Biological Term Annotations 1.0 null carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.52854 ZNF300 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00463919 MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8419-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K78837609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54441 GTEX-XMD3-0008-SM-4AT4V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1464 BRD-K27824953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57177 BRD-K21680192_mitoxantrone_SKBR3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SARS-CoV_84Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.00446 GTEX-XOTO-3026-SM-4B65M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828466 BRD-A88691416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18613 HUT102 CCLE Cell Line Gene Expression Profiles 1.0 1.937 BRD-A56592690_PX12_VCAP_6.0_h_30.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles 1.0 1.15071 Brain Lower Grade Glioma_LGG_TCGA-HW-A5KM-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of immune system physiology GWASdb SNP-Phenotype Associations 1.0 0.359333 NF-kappaB MotifMap Predicted Transcription Factor Targets 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -1.63443 FOXP1_01_210 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60206 BRD-K56126872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1318 SPIB JASPAR Predicted Transcription Factor Targets 1.0 null BRD-A30437061_Camptothecin_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K53343197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46965 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B4-01A-12R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38019 Lung adenocarcinoma_LUAD_TCGA-55-7994-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-638 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 BRD-K67592986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68503 BRD-K44427106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.63367 GTEX-QDVN-2026-SM-3GAEP GTEx Tissue Sample Gene Expression Profiles 1.0 0.853427 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.05289 STAT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00742547 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963826 B4GALT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00492381 BRD-A75409952_wortmannin_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K17743125_belinostat_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7R7-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K78747341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34257 BRD-K49401787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2876 GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33671 HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.930205 SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.28656 BRD-K26647686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08975 viral infectious disease GWASdb SNP-Disease Associations 1.0 1.37604 tagging GeneRIF Biological Term Annotations 1.0 null 15897907-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null polish GeneRIF Biological Term Annotations 1.0 null TIFAB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00614233 GTEX-T6MO-0008-SM-4DM6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19869 TBX21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00723595 GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25277 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18758 Ebolavirus(EBOV)_2day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.00409 Lung Diseases CTD Gene-Disease Associations 1.0 1.15763 ELK1 JASPAR Predicted Transcription Factor Targets 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.9338 KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9088 Lung squamous cell carcinoma_LUSC_TCGA-22-5480-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ML-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null screening GeneRIF Biological Term Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4869-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12868556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03174 P4HB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00684231 BRD-K09975370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34471 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 1.24837 BRD-K80630598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03433 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23075 BRD-K59851511 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09695 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4173-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM98 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00723241 BRD-K03015524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04175 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9088 hsa-miR-4488 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06486 GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00373 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49851 GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60286 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24406 GTEX-Q734-0008-SM-48U2I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78623 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5875-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.853714 MYC_01_231 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.34929 BRD-K74540252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02743 BRD-K67353973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36031 BRD-K69516039_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NFIL3 JASPAR Predicted Transcription Factor Targets 1.0 null paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1139 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10873 cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1805 primary motor-sensory cortex (samples)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82815 CTLA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00518121 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09721 SPI1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00700034 BRD-K97943226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44735 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27325 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38021 HLA-DRA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.004957 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13234 VNN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00703125 BRD-K01329192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15221 polymorphism GeneRIF Biological Term Annotations 1.0 null LAIR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00885184 Atrophy CTD Gene-Disease Associations 1.0 1.23296 GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988626 CEACAM8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00713055 BRD-K81665173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.65741 BRD-K53943097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21546 BRD-A02481876_Importazole_PC3_24.0_h_60.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4734 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 hsa-miR-516b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 hsa-miR-3913-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 NR4A2 JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-3189-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 BRD-K23467057 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1451 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18599 FGFBP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0056685 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SH3BP5L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00532314 BRD-K01793276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39955 BRD-U51024685_HG-6-64-01_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K12929741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00923 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles 1.0 1.07214 icSARA deltaORF6_60Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.53971 GTEX-QEL4-0826-SM-3GAF2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.890811 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1057 hiv GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6356-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44797874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04059 Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.910683 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null Fetal Growth Retardation CTD Gene-Disease Associations 1.0 1.06952 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7068-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CALU3 CCLE Cell Line Gene CNV Profiles 1.0 1.65325 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01304 BRD-K92929998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52784 motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.957023 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-CA-04-2009(H1N1)_36Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.12784 SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14003 GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34258 dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.83792 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.980376 GI1 CCLE Cell Line Gene CNV Profiles -1.0 -1.61256 AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.36494 BRD-K55638368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02518 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.43413 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29384 SNUC2A CCLE Cell Line Gene CNV Profiles -1.0 -1.52453 BRD-K32896438_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4756-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles 1.0 0.850704 hlab44 GeneRIF Biological Term Annotations 1.0 null effect GeneRIF Biological Term Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J9-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U5-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.953218 TNFRSF6B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00628656 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2727 Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JMJD6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0051181 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.140136 sodium-phenylacetate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28939 GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77809 GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.25781 SERPINB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00551867 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.038486 FBN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00631934 BRD-K63624341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19018 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50908 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41122 GTEX-S7SE-0008-SM-33HB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90644 GTEX-O5YV-0008-SM-4E3HP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53091 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.7116 GTEX-QDVN-0526-SM-48TZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08103 GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982987 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7XN-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSMB8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00576071 BRD-K13792178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84002 AR-19668381-PC3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K54256913_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 1.56427 TADA2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00687462 AIDS progression GWAS Catalog SNP-Phenotype Associations 1.0 1.00661 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5261-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fetal Brain Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.29318 BRD-K60762818_DESIPRAMINE HYDROCHLORIDE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06693 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.54961 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VG-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21680192_mitoxantrone_A549_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26C-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16247913 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.92407 Liver Diseases CTD Gene-Disease Associations 1.0 1.19477 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40133 IL9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00469408 GTEX-X585-0008-SM-46MU4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12915 LN18 BioGPS Cell Line Gene Expression Profiles -1.0 -1.23415 BRD-K35897342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32304 STK39 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00531228 posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05062 nevirapine GeneRIF Biological Term Annotations 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles 1.0 0.863643 GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 2.4416 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SARS-BatSRBD_96Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.29288 SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46415 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.829386 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52535 BRD-K87737963_CYT387_BT20_3_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OR2L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00612584 BRD-K23196166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54072 BRD-K92498491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0167 BRD-K90157100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05359 BRD-K97741413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74581 GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26045 BRD-K04623885_BIBR1532_RKO_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57045 stevens GeneRIF Biological Term Annotations 1.0 null GLP1R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00519649 BRD-K55171585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.43336 BRD-K47895166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16816 BRD-K96120749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.4835 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.898884 cochlear nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4758 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD163 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00772476 BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.83122 BRD-K54495109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1136 GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 1.56351 BRD-K10989739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47108 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.882731 Brain Lower Grade Glioma_LGG_TCGA-FG-A87Q-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Proteinuria CTD Gene-Disease Associations 1.0 1.02188 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K39649723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14369 BRD-K58674774_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QDT8-0008-SM-48U2F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29605 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K03810133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23979 BRD-K11251396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19061 GTEX-Q2AI-1126-SM-48U19 GTEx Tissue Sample Gene Expression Profiles 1.0 0.833091 GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 1.48662 GTEX-UJHI-1126-SM-4IHLN GTEx Tissue Sample Gene Expression Profiles 1.0 1.02461 VCAN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00403252 NET1_KD_GDS4196_436_human_AGS - gastric adenocarcinoma cells - (63 shRNA Knock-Down) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-UPK5-0008-SM-4IHJD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26809 GTEX-OIZI-0008-SM-2XCFD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07894 SVEP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0046099 Brain Lower Grade Glioma_LGG_TCGA-CS-4941-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KPNRTBM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.58629 hlab57 GeneRIF Biological Term Annotations 1.0 null GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.02985 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null LIN28B_01_153 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.5901 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 1.49234 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91419355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07998 BRD-K98490050_AMSACRINE_VCAP_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K36352298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.57332 urticaria GeneRIF Biological Term Annotations 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00382 BRD-K16988512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59204 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.90534 GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05109 HL60 BioGPS Cell Line Gene Expression Profiles 1.0 0.947481 GTEX-QESD-0008-SM-447B2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54024 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles 1.0 0.908259 GTEX-QMR6-0008-SM-447AV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76013 znrd1 GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-0008-SM-4DXUW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44513 MAD2L1BP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00476856 hiv infections GAD Gene-Disease Associations 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06343 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6018-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.56919 BRD-M86331534_BJM-ctd2-9_SKLU1_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A-CA-04-2009(H1N1)_48Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.45878 BRD-K42126874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00352 GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.4724 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.84966 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5966-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23531 GTEX-OXRK-0008-SM-3NB28 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8064 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YJ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K99036206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64552 BRD-K80336250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3226 BRD-K43989220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18459 FOXI1 JASPAR Predicted Transcription Factor Targets 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14753 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07160586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88593 Sarcoma_SARC_TCGA-JV-A5VE-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 16424041-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null abnormality of the abdominal organs GWASdb SNP-Phenotype Associations 1.0 0.301765 BRD-K70412800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93155 tool GeneRIF Biological Term Annotations 1.0 null GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08811 MYB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00362734 GTEX-TKQ2-0226-SM-4DM6V GTEx Tissue Sample Gene Expression Profiles 1.0 0.83485 HUG1N CCLE Cell Line Gene CNV Profiles 1.0 2.09647 CTCF JASPAR Predicted Transcription Factor Targets 1.0 null BRD-A36774080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42134 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67F-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-450b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 drug-induced liver injury (flucloxacillin) GAD Gene-Disease Associations 1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1612 BRD-K77820762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63821 GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.83822 Prostate adenocarcinoma_PRAD_TCGA-HC-7233-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K56405136 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10861 GTEX-TMMY-0008-SM-4DXU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.519 TNFRSF1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00391679 BRD-K25226763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20787 BRD-K22874335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58017 BRD-K49415484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00746 BRD-K93040255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04457 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.82047 cell part LOCATE Predicted Protein Localization Annotations 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17309 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01161 BRD-K96101240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73003 BRD-K83935370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49592 BRD-K59701963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15384 BRD-K87815532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07728 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.47158 cSARS Bat SRBD_72Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.77593 NCIN87 CCLE Cell Line Gene CNV Profiles -1.0 -1.36732 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20176 GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913262 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958122 GTEX-XXEK-1626-SM-4BRUZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.99913 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 1.41939 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.66275 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08221 BRD-K90918886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31463 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles 1.0 1.25551 BRD-K31542390_Mycophenolic acid_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K74892102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00298 BRD-K03884263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07414 BRD-K42679315 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.99228 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10232 BRD-K53414658_tivozanib_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2688 BRD-K19231873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8368 BRD-K96893659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27365 hsa-miR-4476 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27736 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23136 AZIN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00552419 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.30482 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7585-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K46056750_AZD-7762_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-UJHI-0008-SM-4IHL1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31321 Psoriasis dbGAP Gene-Trait Associations 1.0 1.5935 16617318-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950902 BRD-K68119260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00772 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles 1.0 1.01088 BRD-K79829201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61094 OE19 COSMIC Cell Line Gene CNV Profiles -1.0 -3.24687 GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95124 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.737335 Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21584435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10307 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860055 abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.392709 BRD-K02708799_GSK-1059615_A375_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FLNB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00634888 BRD-K92978173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04193 TRPM3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00543729 Prostate adenocarcinoma_PRAD_TCGA-V1-A8WN-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spinal trigeminal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.840024 BRD-K02822062_CT-200783_H1299_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K86143816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79028 BRD-K50891186_GR 103691_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K92991072_PAC 1_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HV-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K05645536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86967 BRD-K06203932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.01306 AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52864 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09083 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.82597 BRD-K06148621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00092 Cardiovascular Diseases CTD Gene-Disease Associations 1.0 1.06188 GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles 1.0 1.17757 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K79239947_PF 573228_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NET1_KD_GDS4196_437_human_AGS - gastric adenocarcinoma cells - (65 shRNA Knock-Down) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 19749795-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null attributable GeneRIF Biological Term Annotations 1.0 null GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles 1.0 1.23814 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7100-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epidermal GeneRIF Biological Term Annotations 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995494 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2688 BRD-K93927229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22728 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04668 Weight Gain CTD Gene-Disease Associations 1.0 1.27378 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.99118 BRD-A48237631_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FI-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRY JASPAR Predicted Transcription Factor Targets 1.0 null variants GeneRIF Biological Term Annotations 1.0 null icSARS CoV_48Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.919948 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02836 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MJ-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.07142 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 2.24532 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.985286 Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPATA33 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00645879 Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERFLCKJ CCLE Cell Line Gene CNV Profiles 1.0 1.32968 BRD-A86977540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21611 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null life GeneRIF Biological Term Annotations 1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26521 BRD-K32043305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15801 STK36 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00747238 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06628 caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06086 GM2313 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.485079 dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.878142 GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.58687 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43196 BRD-A48237631_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.945914 FOXD1 JASPAR Predicted Transcription Factor Targets 1.0 null INSM1 JASPAR Predicted Transcription Factor Targets 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H4-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.863118 BRD-A67788537_Salermide_HT29_24.0_h_120.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XUJ4-0008-SM-4BOQI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45169 A-CA-04-2009(H1N1)_24Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.31778 identifies GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4488-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.42906 anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60698 E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K59369769_tozasertib_MCF7_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HSC3 CCLE Cell Line Gene CNV Profiles -1.0 -2.004 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917228 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44096 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null immunodeficiency GWASdb SNP-Phenotype Associations 1.0 2.32949 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.08231 KCND1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00540429 BRD-K21990111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22632 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NJ-01A-22R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07278815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13949 hsa-miR-608 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 viral GeneRIF Biological Term Annotations 1.0 null hiv1 GeneRIF Biological Term Annotations 1.0 null BRD-K87909389_alvocidib_SKBR3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XOTO-0008-SM-4GICE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.74722 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51179 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96848 CTCF_02_185 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.24793 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.615641 BRD-K74039237 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.477 PLAG1 JASPAR Predicted Transcription Factor Targets 1.0 null CL11 CCLE Cell Line Gene CNV Profiles -1.0 -1.5382 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47738 BRD-K81586131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06327 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.865155 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20533 GTEX-QV44-0008-SM-447AX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28325 S1PR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00526675 snp GeneRIF Biological Term Annotations 1.0 null GTEX-X3Y1-0626-SM-3P5YS GTEx Tissue Sample Gene Expression Profiles 1.0 0.865143 GTEX-XUYS-0008-SM-47JYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69957 BRD-K26760349_HG-9-91-01_MCF7_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4916-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26219 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.214784 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 1.27599 GTEX-XQ3S-0008-SM-4GIDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48604 occipito-temporal gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.959228 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00404 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86724 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05236 PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.947132 THP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.67783 abnormality of myeloid leukocytes GWASdb SNP-Phenotype Associations 1.0 0.316989 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-V955-0926-SM-4JBJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08598 BRD-A09975616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30504 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81874 GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911449 rates GeneRIF Biological Term Annotations 1.0 null HIV-1 dbGAP Gene-Trait Associations 1.0 1.74868 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5365-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hcp5 GeneRIF Biological Term Annotations 1.0 null RDH13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00463231 BRD-K22314621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03232 BRD-K46994278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07273 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829867 HS611T CCLE Cell Line Gene Expression Profiles 1.0 2.08392 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3255 ESR2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K47599661 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.02353 not applicable_cell type comparison_GSE49439_365_human_podocytes and progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5092-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A620-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUP-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00696243 IZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.906801 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37814 Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06117861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05964 PDE10A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00723897 Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RH-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52854560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57493 BRD-K85284710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13161 SOX4_01_260 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.00971 MYO3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00475332 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles 1.0 0.827475 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4781-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 NUDUL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.37541 16651414-Supp2 GeneSigDB Published Gene Signatures 1.0 null BRD-K69147598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43305 MAX JASPAR Predicted Transcription Factor Targets 1.0 null HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.948502 RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.889811 GTEX-W5WG-2426-SM-4LMI6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848085 BRD-K35101110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30423 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01365 BRD-K37961770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34043 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.494531 GTEX-RWS6-0008-SM-47JYV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06495 GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.68166 HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.01331 BRD-K35132745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03055 KMRC3 CCLE Cell Line Gene Expression Profiles 1.0 1.41229 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.15269 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12585 BRD-K09777330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81527 BRD-K62288678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7437 Lung squamous cell carcinoma_LUSC_TCGA-66-2765-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALDH5A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00678971 BRD-K62965247_Tipifarnib-P2_PL21_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K36740062_GSK-1070916_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EB1 CCLE Cell Line Gene Expression Profiles 1.0 2.06195 DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.43413 BRD-K86065375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17824 psoriasis GAD Gene-Disease Associations 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962968