association	dataset	threshold value	standardized value
GSE247862,GSE247863_2_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-16-ZL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522115
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67508052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3841
Central retinal artery occlusion	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504078
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.44001
CRCGN015_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7124
DEFB4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573348
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45732260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05941
BRD-K35936801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49876
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF4G1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587171
BRD-K42679315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92838
GLI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13439
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32663
BRD-K39913853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1048
FANCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32228
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64499
PMC7441006-41388_2020_1389_MOESM2_ESM.xlsx-Supplementary_Table_1-Prostate-Specific_MYC_Overexpression_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235572
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38094
BRD-K30053194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19101
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A20242387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28011
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.75173
SK-N-MC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
SLC41A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32018
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55417
GSE237812,GSE237813_3_v_2_hmgb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.71471
BRD-K53401077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04715
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-575-REPIN1_REPIN1	Rummagene Transcription Factor Associations 2026	1.0	null
ALPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08774
KP3	DepMap CRISPR Gene Dependency	1.0	2.01614
Eyespot apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27058632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75639
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.58154
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.56775
BRD-K18211442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65504
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.822
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9239
VDAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533139
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02423
TMEM60	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608785
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7493_RPP40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583074
SAOS2	DepMap CRISPR Gene Dependency	1.0	2.22214
BRD-K12524715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86484
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	2.12499
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00911
BRD-K75637705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01583
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16548
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03141963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70227
GSE211177,GSE211178_4_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3343_GFI1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690191
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Epothilone A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130574
BRD-K56729241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60142
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07912534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35514
BRD-K00767817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16612
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.0657
AGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17652
BRD-K68300789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98059
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0365
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97022
BRD-K12106433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15054
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02321382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29523
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78477132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18646
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NLRC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548595
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.3636
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fraser syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10705
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13051
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5059
BRD-K70302892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01693
BRD-K73475697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57739
BRD-K77401804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12542
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302442
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5717
DBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34007
T84	DepMap CRISPR Gene Dependency	1.0	3.71353
A549_Iniparib_1µM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146585
496100439_PCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2628
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15341
KBTBD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633872
PMC5817105-thnov08p0972s2.xls-SIX3_MTA3-GeneName_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33331
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
TAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94044
SUFU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579365
BRD-K33951208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47873
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.683173
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20751
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285284
SELENOM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574012
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33742
BRD-K04192407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41188
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PRKAR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00366342
BRD-K63654001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02108
GTEx Lung 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.11965
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.64157
BRD-K54247106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26689
CACHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574409
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39567
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
CD58	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466959
AD-11-HV98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208895
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-72-CE19_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243472
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4931
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72083510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55989
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39253
SPRY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00848972
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22002184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46404
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63270352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69183
RPL39L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19878
BDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24706
YKG1	DepMap CRISPR Gene Dependency	1.0	2.4669
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7	DepMap CRISPR Gene Dependency	1.0	2.52273
BRD-K37331547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86206
PRKD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509232
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
7734_SEC13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541562
SMS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0088995
BRD-K20377072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07025
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43054
CRCGN017_MCF10A.TP53.M_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0337
BRD-K19516614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00816
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23628
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-397-SATB1_SATB1	Rummagene Transcription Factor Associations 2026	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.892748
BRD-K10178088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.94864
BRD-K28472865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40219
RH30_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.33424
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75738997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37881
BRD-K81110981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21905
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402042
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-54-JC89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221214
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449928
Methionine adenosyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.693
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34262858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33335
BRD-K06573818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17932
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAPN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68411
LD-69-TV81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218173
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K27885839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56156
LILRA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00660798
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392675
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
phospholipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
UBOX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554121
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.922
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PEA1	DepMap CRISPR Gene Dependency	1.0	2.63061
GSE217694_3_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VSIR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457357
CRCGN016_MCF10A.TP53.M_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26033
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79347939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00702
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39398
BRD-K45576113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0852
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712419
BRD-K41323747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41877
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.65809
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223883
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24337
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403524
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
WM115_SKIN	CCLE Cell Line Proteomics	1.0	2.24859
GSE103068_5_v_8_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74676765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68378
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29144
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02525
BRD-K83218047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54531
BRD-K86086888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16929
BRD-K96493283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27671
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08718
MYOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09019
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PC-44-DH10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252311
BRD-K06049932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1631
BRD-K61439686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6065
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2493
490_ARID3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597796
BRD-K90475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47457
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
BRD-A57174914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07823
PMC4219345-1471-2121-14-52-S5.xlsx-Sheet1-Transcript_bound_to_BORIS_in_6dN_and_down-regulated_during_differentiation_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73330516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15073
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-9.3624
SASH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562659
BRD-K34377350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05466
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71941064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24894
BRD-K48676303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69308
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MF-17-BD63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239433
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09253654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25139
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7613
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46623934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01715
BRD-K67087027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93231
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50409
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K97236134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4927
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00556
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22800340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51782
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527343
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03007
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34375
BRD-K31460017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5934
DOK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061416
BRD-K73840377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28387
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45265701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41428
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31024887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00815
BRD-K83229680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20339
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.14999
CADM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611218
TMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537738
BRD-K71521842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81521
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29295
BRD-K79697020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59235
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0704
PMC4219345-1471-2121-14-52-S4.xlsx-BORIS_6dN-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48604
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76336129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38842
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.812867
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65996
DA-10-HD17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416669
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ethylmalonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
BC-72-DZ30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245306
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PAK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533887
PMC11385078-jciinsight-9-172336-s278.xlsx-Sheet1-Supplementary_Table_4_A_Differential_proteins_from_AA_BLCA_and_EA_BLCA_tissues_using_mass_spectrometry_based_proteomics_analysis_from_Figure_1C_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88274759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20722
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3083
BRD-K13697445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02417
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269495
BRD-K76426411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01911
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Anal fistula	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3691
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A63503250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8491
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2291
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-72-MJ27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216833
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76755
COGN305	DepMap CRISPR Gene Dependency	1.0	2.98322
BRD-K23593468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20331
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47862
GSE213746_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27092365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68651
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00787853
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32118188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45191
PMC4335056-pone.0116726.s005.xlsx-TX100_NOT_X-ChIP_QE-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72468471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01312
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80052
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21354
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Verbal declarative memory	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6685
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.874286
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_hic_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
SELENOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05405
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
NE-37-JX51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224699
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54845
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.644506
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
DU145	DepMap CRISPR Gene Dependency	1.0	2.256
BRD-K47028303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.007
OSBPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62421
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.60156
BRD-K52391588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12661
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.667195
BRD-K13204142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02069
NYNRIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30628
CB-24-FA25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274632
BRD-K51454545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95241
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
CDKN1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598787
RHJT	DepMap CRISPR Gene Dependency	1.0	2.29457
BRD-K96154586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00612
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TREX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758948
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553051
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7387
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A42536341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16862
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.07099
Gastric cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K69093885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96957
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.74221
BRD-K75529374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87597
BRD-K83459401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34591
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5194
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP5PB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524522
496100425_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25961
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87015
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EPN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432752
BRD-K79688948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40512
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06264262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29811
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-MXE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38211037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36821
BRD-K84517695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26839
Noonan syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	3.91694
d11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573919
GSE210580_4_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32018176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01431
BRD-K83189379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83733
BRD-K65147077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2858
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311158
BRD-K42650945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38718
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6807
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-42-ZNF589_ZNF589	Rummagene Transcription Factor Associations 2026	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-13-WB79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202436
RPS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636369
GSE247862,GSE247863_0_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22229548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71464
BRD-K83755051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37303
496100654_HIP_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61265
BRD-K61522760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43217
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59285
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153443_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
FU97	DepMap CRISPR Gene Dependency	1.0	2.85864
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173810_4_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5368
GSE164874_5_v_13_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.094
SH3BGRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00661
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K22661969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75272
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35487
BRD-K02471501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02324
laminin-11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.684
10442_ZNF554_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50082
IL16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610462
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ADAM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36538
BRD-K21935128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66024
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.754452
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68134791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20872
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331611
BRD-K84310612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11927
CRCGN014_HEPG2_3H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07075
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF831	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04915
BRD-K00530465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78094
GNG11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053084
496100589_PCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10638
CD1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681316
NCIH2110_LUNG	CCLE Cell Line Proteomics	1.0	2.37345
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20758
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.69311
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7228
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0466
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.431269
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ECGI10	DepMap CRISPR Gene Dependency	1.0	2.1795
BRD-K44052748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72523
TMEM134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09443
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-401-NR4A3_NR4A3	Rummagene Transcription Factor Associations 2026	1.0	null
5205_MRPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61237
MEWO_SKIN	CCLE Cell Line Proteomics	1.0	2.91249
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42558179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1153
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97415
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08423
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8441
2796_EXOSC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.690645
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PKIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520546
OCUM1	DepMap CRISPR Gene Dependency	1.0	2.29584
EF-62-IO23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357711
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244326
EIF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572956
BRD-K17705318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19591
BRD-K34804325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66115
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23505
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399017
PMC11076560-42003_2024_6230_MOESM5_ESM.pdf-42-ENSG00000164048_ZNF589	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RA-49-ZB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259762
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21470524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28728
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55517
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44012257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46948
GSE143643,GSE143644_2_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.0485
VPS26C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648939
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.45691
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346742
BRD-K75281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09103
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69569
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MB-49-LL22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34843
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628409
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28274866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09138
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212289
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00486
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7793
GSE212074_0_v_1_pus1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64215435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04763
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5817105-thnov08p0972s2.xls-SIX3_LSD1-GeneName_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30285881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36507
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200799
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215561
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68583
BRD-K59821372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37155
BRD-K37991633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30636
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4381
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81087
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3087
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Clopidogrel_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0102325
KEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500068
PMC4642629-12864_2015_2169_MOESM10_ESM.xlsx-Hs_TSS_peaks_vs_ZF-Schödel_Genes_with_peaks_-_1Kb_from_TSS_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GA-94-KZ19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220052
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327447
MCF7_Andarine_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133456
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8801
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.09381
BRD-K30601921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30295
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7579
BRD-K14778436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52066
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GAS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561069
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7135
BRD-K71537579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8699
BRD-K11625057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33905
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539905
PLA2G2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739296
Cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49285
ATP1B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711798
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.1756
BRD-K79199168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06727
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480888
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.76898
BRD-K73635724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1583
SLC22A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694601
BRD-K49050984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37278
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260274
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05796780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7924
BRD-K14795621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23327
CYP20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2042
BRD-K98249237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60348
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2879
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42572
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.83699
VACTERL association	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311076
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19354
BRD-K24529791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39602
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.69415
CYP2S1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00758066
BRD-K30655307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04798
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4632
BRD-K50726251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36266
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60785
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60409
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.14241
STAT5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549596
MDAMB436_BREAST	CCLE Cell Line Proteomics	1.0	2.90784
OXCT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00336457
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.30544
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6841
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15999
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A84764193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21162
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03657
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19132
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1721
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE254770_3_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56301
STIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9808
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0023
BRD-K26395018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99958
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18945
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
DNAJB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27672
GCLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81349
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K41561756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34299
BRD-K17675523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41107
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
glycerophospholipid metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59120074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19553
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AD-50-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229411
2313287	DepMap CRISPR Gene Dependency	1.0	2.98312
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42139332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14762
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6817
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.633925
CADM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26542
CSF2RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622445
BRD-K14116382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59406
GSE244199,GSE244200_0_v_1_chmp5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79584
BRD-K76500652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09449
BA-52-FW03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.664344
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72513
Leydig cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7913
BRD-K52157065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40843
GBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00392719
496100503_HIP_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4423
KYSE450	DepMap CRISPR Gene Dependency	1.0	2.18348
PHOSPHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3426
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.158
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K70851631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06588
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285963
BRD-K29130550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54683
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10075
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326912
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_7_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
NELFB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570477
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4174
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00436626
BRD-K06094529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91715
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4164
LS123	DepMap CRISPR Gene Dependency	1.0	2.59122
BRD-K47275094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32883
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0967
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
TMIGD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048869
Epithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256074
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89855
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73592
BRD-A55574211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0234
AF-42-MP86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252103
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
T24_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.09432
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243535
CT45A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569771
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K87595216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39168
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288852
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0333
ENTPD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682483
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36804
Neuroepithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56426074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09253
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3378
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.56542
BRD-K67344728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50026
RNF115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92416
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222653
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.881
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0866
5919_STN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565827
CD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697855
BRD-K73874262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38638
ZBTB7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601218
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RPL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01366
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-37-XI06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357184
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14734
BRD-K00950228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63914
GAL3ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38584
WDR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00723092
KCNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572745
GSE151494_10_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VC-19-YG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.46617
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0749
BRD-K24109044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38598
G402	DepMap CRISPR Gene Dependency	1.0	2.46164
SCC9	DepMap CRISPR Gene Dependency	1.0	4.95985
CRCGN015_MCF10A.TP53.M_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1309
BRD-K95943192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67369
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2643
MIER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0116
BRD-K96393402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47942
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.64758
BRD-K46141002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23673
CB-24-FA25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20371
DAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10245
TRMT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05989
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33078
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371213
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75821161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84865
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05246869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22097
BRD-K10058823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49379
GSK3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520531
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467236
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.721914
SH3BP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05848
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
496100643_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2551
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31845
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231871
3635_HAUS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51005
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83823
BRD-K50300854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09008
BRD-K43341506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24098
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44779670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03063
RGS12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671903
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.94945
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3057
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PLAU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56411
AC-97-KP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200988
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243403
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00131
BRD-K16791544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3589
Intracellular anatomical structure	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2033
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.90812
BRD-K97138361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91372
BRD-K66754362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28991
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8364
A388	DepMap CRISPR Gene Dependency	1.0	3.37483
HEG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02302
BRD-K84673192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32775
BRD-A60487173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61419
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64966
SCARA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522702
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50224
BRD-K82244940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37632
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0
BRD-K43674766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41831
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
BRD-K64194889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32674
SCH	DepMap CRISPR Gene Dependency	1.0	3.27964
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7985
BRD-K96198015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0461
METTL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95019
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WNT9B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627109
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09455
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
KNS60	DepMap CRISPR Gene Dependency	1.0	2.42576
QE-35-YE15_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227077
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3074
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16142
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15694
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.86267
PMC9314667-Table_1.xlsx-Regulons-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.04015
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_26_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.0019
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9401
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52922
CRCGN015_MCF10A_48H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05855
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K51181201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84313
HEPG2_LIVER	CCLE Cell Line Proteomics	1.0	5.10188
NKX1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32713
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05050615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24345
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71194915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60934
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.23103
PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03055
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS746T	DepMap CRISPR Gene Dependency	1.0	2.11906
KCL22	DepMap CRISPR Gene Dependency	1.0	2.52385
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00424576
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49164
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.714014
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2625
AC-80-DI95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.700453
BRD-K01894374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32283
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K80469338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53827
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211437
KE-06-DQ22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221579
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7656
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63593
CRCGN015_MCF10A_48H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0104
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.49407
ZNF80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529496
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A96536816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69913
BRD-K46913557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01376
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13724
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323513
BRD-K92246187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32478
BA-15-VE07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210881
BRD-K77417197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19511
GSE146747_0_v_1_nr4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63645840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48959
BRD-A97198094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64208
UMUC9	DepMap CRISPR Gene Dependency	1.0	3.7809
BRD-K59709463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49618
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cyclocytidine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30887
BRD-K68663367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17214
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4773
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17125
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8323
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6383
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4334
BRD-K24752397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14451
CRCGN015_MCF10A_48H:F06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4908
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K15478481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53387
BRD-K68608492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11325
BRD-K82637883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14445
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07075
PMC5985538-mmc2.xlsx-selected_2X_in_2_exp_SALL1_FL-Gene_names_SALL1	Rummagene Transcription Factor Associations 2026	1.0	null
HUO9	DepMap CRISPR Gene Dependency	1.0	2.20268
HDAC10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0043943
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60661821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88147
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392775
SCMH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27775
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUDHL4	DepMap CRISPR Gene Dependency	1.0	2.26943
BRD-K00976973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35801
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61134709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97607
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160817_5_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211403
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317473
QRICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27235
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.822257
SUMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544364
BRD-K63757821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06895
SKNMC	DepMap CRISPR Gene Dependency	1.0	3.32936
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-BETA4-379_common_elements_in_shEP400-1_BETA_shEP400-3_BETA_shMYCL_BETA_and_shEP400-2_BETA_BHLHE23	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50108835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14144
BRD-K33767317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10988
GSE152432_9_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91470977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17473
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94543
BRD-K22471908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45075
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEXA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12644
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5988
AVL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78101
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.3208
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32851
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.28135
CRCGN008_HEPG2_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2722
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6777
BRD-K44007425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82494
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0751
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460007
GSE224131_3_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
TIGIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690182
BRD-K86986466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32059
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73799
CALU1	DepMap CRISPR Gene Dependency	1.0	3.10137
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3822
BRD-K84459640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46256
FB-12-UL66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260201
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.64539
HDHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01229
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1477
KRBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1432
ZBTB38	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00789356
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRPC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00308197
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61657
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07153
BRD-K35716266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3476
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aplasia of lacrimal and salivary glands	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467077
IA-27-CK10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517198
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216147_2_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15546
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4686
QC-10-TY16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346694
BRD-K67229323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55023
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ULK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00440074
BRD-K74767736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44817
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8717
BRD-K03995743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02581
Noonan syndrome with multiple lentigines	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
3-M syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
BRD-K31354456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32526
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.35462
BRD-K89652482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05322
GTF3C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26901
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HUPT4_PANCREAS	CCLE Cell Line Proteomics	1.0	3.10623
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.99301
GSE154940_1_v_0_nbdy_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNA polymerase I upstream activating factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.981
BRD-K52492854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71318
Interstitial cell of Cajal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.658
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.621453
CUX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4531
BRD-K49108064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45955
CCDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17931
BRD-K04791118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15808
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520362
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317253
MBOAT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37888
BRD-K56106571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4556
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59266
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.848816
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140092_2_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59046641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34761
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498911
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2438
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3784
BRD-K99681648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60516
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71411
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311904
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DBNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35873
SLC25A20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00809058
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.382
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80779045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49141
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39447
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203896
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.40828
Anal fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
BRD-K91795767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69633
ADAM30	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609104
BRD-K86586698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78706
CE-04-HT15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245839
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.385
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30373
ZNF184	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584885
CRCGN017_MCF10A.WT.HP_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1275
BC-72-DZ30_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241759
SOWAHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06403
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93310782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29348
BRD-K25842662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52426
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6109
BRD-K66939340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39005
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47371
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63123
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH446	DepMap CRISPR Gene Dependency	1.0	3.58104
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882912
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211924
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98088240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63789
Triglycerides Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K09304381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0092
GSE143643,GSE143644_4_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1272
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330705
MM386	DepMap CRISPR Gene Dependency	1.0	2.42375
BRD-K16268355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63606
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02425
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.831804
BRD-K80816131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53014
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8638
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69606
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.148
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63711467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23485
DD-89-WQ95_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321038
IRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02482
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635543
BRD-K08472586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16847
BRD-K75037209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20657
PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A43135847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28485
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454873
BRD-K04939366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04571
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-42-IC00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203925
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430744
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350384
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12578029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23609
SHISA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499258
BRD-K47508820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86035
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-26-BE29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246621
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278373
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12634441-41375_2025_2771_MOESM7_ESM.xlsx-RNAseq-Table_S2_Bulk_RNA-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A05956997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80711
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B3GAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459427
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hydroxyfasudil_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219075
BRD-K92776249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04046
RASopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FBRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12619
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.638409
SB-94-ZA83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443533
EFHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495809
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
ME-62-IQ37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299519
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8159
BRD-K50417536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.83447
A549_Resveratrol_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150238
BRD-K59744424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15138
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71621
BRD-K89995901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05967
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36376229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32071
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHGDH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00351181
BRD-K17659275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68878
BRD-K30372674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18854
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.62912
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55831
BRD-K77173942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0506
CLEC2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00440614
MKN28	DepMap CRISPR Gene Dependency	1.0	2.62374
DE-62-FI29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200396
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.79504
BRD-K02747732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51608
NID1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476747
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92059157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35037
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SKN3	DepMap CRISPR Gene Dependency	1.0	2.42478
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9675280-12950_2022_317_MOESM3_ESM.xlsx-siPAD2_LPS_vs_siCON_LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29819
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69152679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19579
GSE202603_0_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PACADD119	DepMap CRISPR Gene Dependency	1.0	2.45687
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21234
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BB-28-MC54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460488
CRCGN015_MCF10A_48H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00867
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN4_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01749472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16089
SUPV3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28231
BRD-K66831269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01815
BRD-K13515483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16655
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2695
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73842
BRD-K04810287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02464
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RORA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502465
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74955
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.40475
Wing bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.691914
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66558
Melanophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.658
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05173
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254662
BRD-K33151492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40921
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
TC32	DepMap CRISPR Gene Dependency	1.0	3.33972
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.08339
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.898166
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NADSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17389
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69854611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22744
PMC9714459-DataSheet3.xlsx-Supplement_3A-1037_elements_included_exclusively_in_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41033271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68322
BRD-K26402831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10163
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81457218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1705
BRD-K35133923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30544
SKGII	DepMap CRISPR Gene Dependency	1.0	2.27267
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53396471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81681
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95148987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20898
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6360815-supp_gr.239053.118_Supplemental_Table_S2.xlsx-MAFs_targets-Table_of_potential_MAF_targets_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
glycerolipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
NCIH1650	DepMap CRISPR Gene Dependency	1.0	2.06238
ELAVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3486
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.838852
BRD-K90019187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75856
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449986
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38742
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC12A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13301
MYBBP1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451768
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34722
BRD-K42016545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24916
ZNF646	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00740515
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47874
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54621976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35302
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21176717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18077
VHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25276
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCT15_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.39624
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K88948585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17694
BRD-K54003455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4674
RAD51C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01649
EB-07-JB09_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400562
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-NFYB_NFYB	Rummagene Transcription Factor Associations 2026	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.720743
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25381
BRD-K25954314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07432
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33420995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57943
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3942
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53458780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5241
BRD-K56802897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76394
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
KPL1_BREAST	CCLE Cell Line Proteomics	1.0	2.05108
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-80-GK24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201893
IRF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558278
Pelvic fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.879
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6863
PPP2R2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05342
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPTBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670305
BOKU	DepMap CRISPR Gene Dependency	1.0	2.97593
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7929
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25083
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26858
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A67552019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0385
WEE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512572
PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT1_AKT2_KD_vs_SCR-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
UNCX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064743
CRCGN016_MCF10A.TP53.M_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12442
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS294T_SKIN	CCLE Cell Line Proteomics	1.0	3.22756
4107_IMP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690158
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.1466
BRD-K54538111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2691
OSBPL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44578
BRD-K39081386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1006
BRD-K40018788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06768
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4225
ACSM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650547
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43797
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3391
CASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48667
PMC9927941-jci-133-163612-s045.xlsx-Sheet1-Table_S11_DEGs_with_a_PAX5_binding_motif_as_identified_by_Pscan_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22039769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61828
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370577
BRD-K69699301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24736
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25419
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CCLFPEDS0003T	DepMap CRISPR Gene Dependency	1.0	5.49735
BRD-K59870481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34392
GSE182179_2_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58107
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65115
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260037
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL120_BREAST	CCLE Cell Line Proteomics	1.0	2.05621
BRD-K50815029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28409
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156899
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0959
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22748970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11163
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543299
BRD-K22874335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28402
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
butylated-hydroxytoluene	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13009
PCI6A	DepMap CRISPR Gene Dependency	1.0	2.19749
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598405
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46425
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.869115
ANKRD23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34141
BRD-K33236055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54207
IRF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503004
KYSE410	DepMap CRISPR Gene Dependency	1.0	2.94872
TNFSF18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534143
HSPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11156
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06888
BRD-K47707657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29913
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39752
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.357
BRD-A95239561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03412
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB3IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535723
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70794
BRD-K55286508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04658
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14671528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57725
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17302
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72519034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00258
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225083_0_v_1_kras_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10189430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50759
HCE4	DepMap CRISPR Gene Dependency	1.0	3.56818
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231189
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_8_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCN4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36652
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.526
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
ING3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13935
BRD-K66425065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08571
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.790276
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.59918
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3490_GPATCH2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56241
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91865
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304743
BRD-K15378071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29002
BRD-K74015591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25679
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190384,GSE190386_2_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
THBS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712699
BRD-A69383366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0277
BRD-K83122599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12421
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08165
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VNN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529205
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282059
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02172
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27594
PMC4335056-pone.0116726.s005.xlsx-Biol_2_QE_NOT_FT-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26809097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23095
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21035
Astrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8552
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550567
A549_AICAR_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136106
BRD-K17384993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07793
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
MBNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059486
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0275
BRD-K40248932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60437
GSE144484_0_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50479
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12486367-Supplementary_Data2.pdf-336-ZKSCAN5_ZKSCAN5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.347
JB-48-AO57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278416
DAGLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048904
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288187
GZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03456
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DB	DepMap CRISPR Gene Dependency	1.0	3.26675
BRD-K75610411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8666
BRD-K65934178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26355
PMC3910540-725780.f1.xlsx-Table_S5-MYC_target_genes_in_human_ES_cells_Ji_Wu_et_al_2011_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19983
PMC10594727-13062_2023_428_MOESM14_ESM.xlsx-Sheet1-PPARD_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02661
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69496
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6024
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
SPAG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06522
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_1-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01668
BRD-K01083922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9119
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.22296
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
phospholipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.670306
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.890008
BRD-K37433647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12871
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8269
5103_MKX_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641868
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07979
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
BRD-K61698250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74548
BRD-K97576000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06369
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRKAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23997
CDC25C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16714
BRD-K92524632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04931
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26199
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43982279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3634
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37486
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83659
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39669
BRD-K87259147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25365
BRD-K69291887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15963
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
THG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06929
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.178
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02257
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.43091
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.526
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30744
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4651
CRCGN015_MCF10A.TP53.M_24H:L06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84925
BRD-K95688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12531
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
COPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52738
BRD-K62226454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15318
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67905771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85841
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
p190	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
PMC8758144-elife-74272-supp3.xlsx-AP1_REP2-GeneName_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.876728
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial alpha-ketoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
CEP350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00374
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-63-KC77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237846
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5809
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78121
MFGE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20075
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.47122
UE-90-AA63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27086
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.357
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138024_2_v_3_rgs4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61407677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1099
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230366
BRD-K70262646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66462
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.45059
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53356402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26113
BRD-K03035008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.685
BRD-K61485947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01669
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134375_0_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.26413
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.20186
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25773863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50218
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14132
K562	DepMap CRISPR Gene Dependency	1.0	3.63336
PSMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1588
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50058129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68466
ESO51	DepMap CRISPR Gene Dependency	1.0	2.21785
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21472066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13084
chrysophanic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66013
SUM190PT	DepMap CRISPR Gene Dependency	1.0	2.7272
EPHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0879
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30143
LMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35541
BRD-K17065706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07507
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6788
OC-21-IP52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321026
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A73150064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02141
PWWP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29489
PMC11297914-41389_2024_531_MOESM1_ESM.pdf-278-ZNF488_ZNF488	Rummagene Transcription Factor Associations 2026	1.0	null
DA-58-LZ09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21011
SMTNL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576159
BRD-K88351048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05373
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.619233
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5961
C33A	DepMap CRISPR Gene Dependency	1.0	4.58566
BRD-K89094496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98354
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15267
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205021_3_v_2_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32372
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234568
BRD-K56761719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42343
UBD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646631
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645914
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7842
BRD-K45282766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54865
BRD-K74834319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08522
EB-67-WB79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500446
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SIX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54337
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TSPYL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08779
BRD-K64055457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94206
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204046
GSE144484_2_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30978
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88902
SAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13994
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08285
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61685
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87262
GPATCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25808
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77433
HCC2998	DepMap CRISPR Gene Dependency	1.0	2.36942
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9901
BRD-K19327124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78942
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19586
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2678
EHHADH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00936746
COLO829_SKIN	CCLE Cell Line Proteomics	1.0	2.63602
chr22_17179161_G_C_b38	GTEx eQTL 2025	1.0	1.2427
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_Ref_Can-ZNF205_ZNF205	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43594798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12069
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97067262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98566
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6277
MON	DepMap CRISPR Gene Dependency	1.0	4.2961
SHP77	DepMap CRISPR Gene Dependency	1.0	2.37438
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.72521
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58890106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94821
CD68	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692274
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00464658
ANLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58428
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THADA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674379
BRD-K11516621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34613
chr22_17158409_A_C_b38	GTEx eQTL 2025	1.0	2.30783
Intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2419
BRD-K18310625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35219
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.920031
BRD-K47348275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08101
Intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.259
SGCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44521
HLA-DQA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084025
PFKFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594153
RIEG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780373
SORL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066651
KCNJ10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482463
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86421
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.961072
C17orf75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48651
Gastric adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.44118
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228741
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02628
ADRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08746
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.935996
BRD-K82446079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32593
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385963
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_2-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
QDPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044815
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K89432538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58039
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC13A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549527
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07589203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41299
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396978
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581497
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S01_LF_C1_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHLDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3594
LCAM1	DepMap CRISPR Gene Dependency	1.0	2.66754
GSE193624_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00565
HS695T	DepMap CRISPR Gene Dependency	1.0	3.10871
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.55785
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6753
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81544
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54372
GTEx Lung 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-9.35408
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25305749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0827
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0258
PMC9927941-jci-133-163612-s047.xlsx-Sheet1-Table_S13_Co-expression_analysis_on_the_395_T2D_DEGs_showed_that_PAX5_is_part_of_a_gene_network_containing_87_genes_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39406901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47165
glycerophospholipid metabolic process	GO Biological Process Annotations 2025	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2241
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_BREAST	CCLE Cell Line Proteomics	1.0	3.76829
CRCGN017_MCF10A.WT.HP_24H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1214
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9646
HT144	DepMap CRISPR Gene Dependency	1.0	2.80299
BRD-K36493118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35421
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46994278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0579
C18orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0131
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255733
BRD-K83307202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16843
CRCGN008_HEPG2_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1098
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07265
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.25208
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.178
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.511406
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.526
S100A16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08562
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220257
RAP1GAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93565
CRCGN015_MCF10A.WT.HP_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08044
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9574
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28943
Anchoring collagen complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
BRD-K70992537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45073
LADD syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.957088
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
KALRN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629321
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02922
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04758
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52352
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07278381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71574
MCF7_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01276
PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_2_MAF_downregulated_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82379643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51812
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0627
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13335
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ELOVL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683485
NCIH727	DepMap CRISPR Gene Dependency	1.0	2.35088
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98953112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04465
BE-66-UB12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23722
BRD-K05444553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39959
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OBSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601657
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MELHO	DepMap CRISPR Gene Dependency	1.0	2.03735
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-42-ZV45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238438
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K86988191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23442
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.62047
GSE158834_10_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10886
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384983
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397049
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1298
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663864
BRD-K73430970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11598
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24757
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.505099
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.529708
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADGRE5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544322
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4472
BRD-K72801689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14714
TRIP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19129
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2161
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
TC-95-IR96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907302
BRD-K07230804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73443
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456811
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8201
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.60564
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227992
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-442_common_elements_in_HIF1_peaks_and_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
TFB2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04916
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494032
BRD-K00078503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12277
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A55025683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47765
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.511226
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2561
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.63023
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	61.3085
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49573242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07736
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47709
SMSCTR	DepMap CRISPR Gene Dependency	1.0	3.7731
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6424098-mmc5.xlsx-CEBP_Binder-Gene_names_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501912
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4449
PARP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00327017
BRD-K82102352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84556
glycerolipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50325214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03114
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.16599
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.910751
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518649
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.562
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01978082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73712
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pituitary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.20861
UF-61-QB73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466149
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-8.70578
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.3674
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6469
ACTR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00386674
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489146
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S0-EE-XMXE_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288568
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN3_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648574
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208415
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3476
BRD-K07665396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45446
BRD-K34360192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25621
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34515
Xanthophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.852
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.6105
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314779
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KNS81	DepMap CRISPR Gene Dependency	1.0	3.13159
FUT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545384
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K18452866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00977
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null