association	dataset	threshold value	standardized value
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50985475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08732
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58715359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60934
protein localization to nucleus	GO Biological Process Annotations 2025	1.0	null
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
Hypomyelinating leukodystrophy 16	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.519
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCE4	DepMap CRISPR Gene Dependency	1.0	2.47026
BRD-K02269304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50478
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19046167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33945
BRD-K03810133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37377
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02615
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59565
BRD-K19710723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4128
BRD-K75186244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16212
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.510485
BRD-K31197843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56863
BRD-K89179622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43168
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78297750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38415
BRD-K86911380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13091
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13781
BRD-K06492501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3858
BRD-K44696459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81871
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.1953
BRD-K30201819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91363
intracellular protein transport	GO Biological Process Annotations 2023	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44760023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1367
1943_CTR9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.593968
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95213130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33666
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226306
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78586
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CJM	DepMap CRISPR Gene Dependency	1.0	2.02017
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A24524033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80539
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77324165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1944
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17884
CRCGN011_HEPG2_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4154
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1-bound_promoters_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.18
LPS853	DepMap CRISPR Gene Dependency	1.0	3.20591
BRD-K94685203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58487
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60511
Hypomyelinating leukodystrophy 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.178
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72843176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08211
GSE163052,GSE163198_4_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43316594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17095
Cellular response to heat stress	Reactome Pathways 2024	1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35696
RCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2682
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2807
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53113
Allan-Herndon-Dudley syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1342
BRD-K24523560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05395
BRD-K23434564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28301
EBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46144
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3607
MERO82	DepMap CRISPR Gene Dependency	1.0	2.8998
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40886
BRD-K07501194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15613
RAB8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63219
ELP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0075
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4368
BRD-K70289438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04355
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447129
NCIH1355_LUNG	CCLE Cell Line Proteomics	1.0	2.33552
BRD-K58268854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23667
BRD-K10871135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37531
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80173
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278265
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92124212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28174
BRD-K98535708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19362
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49530286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2007
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12376164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11672
BRD-K41604824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0661
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39864
Drug dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.869
SMN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.678
Granular component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.904
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512276
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.18
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2821
CCL21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005549
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
DETROIT562	DepMap CRISPR Gene Dependency	1.0	2.09587
BRD-K86938753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16242
EFR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0818
BRD-K28140275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12172
BRD-K14778436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10281
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570483
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342151
BRD-K01627964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25454
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28095
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
LRP12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00862043
at1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.886
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62182
Feeding Difficulties	DisGeNET Gene-Phenotype Associations	1.0	null
EA-40-KQ08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205512
BRD-K99221119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.077
Pelizaeus-Merzbacher disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.969
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2921
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07292
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K72721410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02328
A375	DepMap CRISPR Gene Dependency	1.0	2.09319
BRD-K54964687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29849
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Canavan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332221
BRD-K05119275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66906
BRD-K56520977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02242
Plantaris muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8734
Head capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
CCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04429
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cyanosis	MGI Mouse Phenotype Associations 2023	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.655103
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
emphysema	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K41548770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47322
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8426_SRRT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.659418
organic substance transport	GO Biological Process Annotations 2023	1.0	null
BRD-K71368065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33122
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326717
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.94771
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09324
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48629186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20094
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.472448
BRD-K90571714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07966
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04256
CRCGN015_MCF10A.WT.HP_24H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1854
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59188100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47062
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05523
BRD-K76450447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07967
CRCGN017_MCF10A.WT.HP_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.174
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266932
BRD-K05846874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21213
BRD-K82394273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5021
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62807053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37304
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00667983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19152
BRD-K11057086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02261
IF-03-OL58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217191
BRD-K37506332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3724
Nephron	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246786
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRISPLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689271
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.73838
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KP2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.60299
CRCGN011_HEPG2_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24755
PMC10290283-biol-2022-0622-sm3.pdf-409-TIGD6_TIGD6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21119095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41313
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22346
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57147
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98482
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0762
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
BRD-K55237592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38668
BRD-K47349869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13073
GSE135350_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49282125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35361
MCF7_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176511
GSE151782_4_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MB-49-LL22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21983
BRD-K28391526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10915
BRD-K88038091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47443
UK 383367	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
Fever	DisGeNET Gene-Phenotype Associations	1.0	null
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95485901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28302
NPEPPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1749
BRD-K71493640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38917
BRD-K92712225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38791
CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.84631
CD99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21544
BRD-K04992384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12688
BRD-K34425773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94302
BRD-K76023734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31252
BRD-K05068331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44915
Hypomyelinating leukodystrophy 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.449
BRD-K43981353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3731
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8553
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7976
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2386
GOLT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24781
BRD-K80467627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02761
Hypomyelinating leukodystrophy 22	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.26
BRD-K14359826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20984
Sparganosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32853
BRD-K80807286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08001
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02338
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10035
APCDD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555548
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7471
Aerial root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.972
Hsp70 protein binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2712
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218151
BRD-K27584103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30863
SELENOI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07064
BRD-K56283394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44215
BRD-K65831955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30379
BRD-K24167233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31953
BRD-K72424071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09544
Hypomyelinating leukodystrophy 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.177
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36778
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2276
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289318
HE-84-SC79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213261
BRD-K52202153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07453
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.988
BRD-K34414758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57031
BRD-K10571700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19231
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97540907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11232
BRD-K98088240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2648
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.7759
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fucosidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214301
BRD-K12782513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57947
BRD-K49384706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27687
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.62316
BRD-K85500722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41746
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6234
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-12_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57643011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60427
TDOTT	DepMap CRISPR Gene Dependency	1.0	2.32993
Nuclear stress granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.019
AHI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.004391
ES2	DepMap CRISPR Gene Dependency	1.0	2.94647
Aicardi-Goutieres syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
FBXO46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2299
BRD-K08233096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35213
Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14286
3'-fluorobenzylspiperone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50011
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_HOXC6-gene_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MKS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25639
URB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.061
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14344
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2377
BRD-K19962165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29125
BRD-K22683888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04027
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6194
BRD-K22610244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55722
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11979048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25737
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449801
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30233
5750_NOP58_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540909
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477873
BRD-K67563379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29393
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.18
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95500860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33069
BRD-K11282060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00209
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351894
HAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561362
Nuclear body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pericyte_Lung_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6895
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285875
CA-48-SW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22566
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3462
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01829
BRD-K19755525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09413
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222592
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K70941721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22507
CD84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649548
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88467167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02841
Spastic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441485
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59941
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206916
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44171
CRCGN017_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8532
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
A549_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147084
IM95	DepMap CRISPR Gene Dependency	1.0	2.26461
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28054
BRD-K70533557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25041
PMC12165627-Supplementary_material-Suppl.4-s4.pdf-5-CREB1_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
BRD-K81318113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40219
HIF1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00333969
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.13503
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95543908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06387
LS123	DepMap CRISPR Gene Dependency	1.0	2.42155
NFPS	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
BRD-K62659610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56862
GSE205332_2_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1	DepMap CRISPR Gene Dependency	1.0	2.95693
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412647
PMC9170821-JCMM-26-3183-s001.xlsx-Mic_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00744507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0297
GSE153757,GSE153758_1_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_ITSA-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111072
BRD-K98880643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55131
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323088
BRD-K95455263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05131
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
VSTM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619513
SKNMC	DepMap CRISPR Gene Dependency	1.0	2.44946
BRD-K18944654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53967
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
Hypomyelinating leukodystrophy 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.354
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.872649
BRD-K14520048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63459
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202477
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07550833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16665
RUSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40273
BRD-K32439647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3905
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
PMC3435504-msb201237-s2.xls-Supp_Table_4a-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Interphotoreceptor matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
ING4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634352
BRD-K24369860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06398
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.888
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3438
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51735
Abnormality Of The Periventricular White Matter	DisGeNET Gene-Disease Associations	1.0	null
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36927
EB-66-IH06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208957
Hypomyelinating leukodystrophy 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.289
TMEM140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01994
AC-97-KP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481952
BRD-K16330310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91442
BRD-K19009595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11666
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4926
BEND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11021
BRD-K87803080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37008
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211558
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHL1DM	DepMap CRISPR Gene Dependency	1.0	2.71928
Cell junction	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.411
CD274	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00660938
BRD-K41305193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25458
BRD-K06428422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09001
nitrogen compound transport	GO Biological Process Annotations 2025	1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256121
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1767
BRD-K12867546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17666
BRD-K73014869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02067
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62184784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71043
GSE198165,GSE198166_5_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37276417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84468
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.8071
Hypomyelinating leukodystrophy 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.505
LS	DepMap CRISPR Gene Dependency	1.0	2.75562
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.988155
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0271
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.8084
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20759
BRD-K21327356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28703
NB7	DepMap CRISPR Gene Dependency	1.0	2.34192
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67703
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454783
BRD-K08806664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32732
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87261
BRD-K05135707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01075
Rucaparib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
Bronchiolar epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
u	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
MAJIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20964
BRD-K07667635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00165
KMRC1_KIDNEY	CCLE Cell Line Proteomics	1.0	6.23346
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
2,2'-Biquinoline	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
ONS76	DepMap CRISPR Gene Dependency	1.0	2.44315
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K18978916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02641
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284469
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.1679
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6264
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02699
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.894
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46985581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43302
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3895
BRD-K59335919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58333
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.65167
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.43354
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41866
BRD-K47261271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93717
Terminal bronchiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252345
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200979
HE-22-JR80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.454972
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Perindopril	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
BRD-K91399333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63136
BRD-K51934291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75508
EE-85-SK26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247051
BRD-K29178949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09118
CYP26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09091
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34116
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246713
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PEO4	DepMap CRISPR Gene Dependency	1.0	2.60444
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5932
NG25_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00864052
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23268
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47409867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81896
SF-67-CJ22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20222
IC-98-UO17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207772
BRD-K75583553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10745
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19536
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Flexion Contracture	DisGeNET Gene-Disease Associations	1.0	null
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41686
BRD-K24965236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42947
PCI6A	DepMap CRISPR Gene Dependency	1.0	2.37348
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065175
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.38988
CRCGN015_MCF10A_48H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27591
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.86955
BRD-K49039223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04798
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455873
Renal tubule	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1369
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8426
BRD-K23241743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78287
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-575-REPIN1_REPIN1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13681383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28252
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243493
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.96697
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24206299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21692
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82638914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54066
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430106
NRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00935202
TC-95-IR96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256973
PATU8902	DepMap CRISPR Gene Dependency	1.0	2.30809
BRD-K44497547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69509
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:H20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26716
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.37874
BRD-K11571815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12393
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93534327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40411
MSTO211H	DepMap CRISPR Gene Dependency	1.0	2.6886
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33197627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34748
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear speck	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SLC11A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683521
CEP95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26979
BRD-K47337578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0816
BRD-K29111485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2814
Umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB 13	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.507377
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.760916
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595259
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-16-VM54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356292
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2772
GSE176093_0_v_1_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50710005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37975
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C19orf12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73044
ZBTB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17989
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44430448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14861
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42865
CRCGN013_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2245
BRD-K39695412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42426
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280141
BRD-K52319351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34079
BRD-K47577519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10666
ED-03-IP48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343447
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62985
OCIM2	DepMap CRISPR Gene Dependency	1.0	2.82486
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588546
Hallucinogen dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.869
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.640829
B3GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78488
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61768
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07486
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415862
BRD-K31110422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02588
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.86056
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
ZNF785	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70418
BRD-K35058762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21365
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17082
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358881
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.7319
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_ID_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
NVP-BEP800	DeepCoverMOA Drug Mechanisms of Action	1.0	0.95
GSE228106_3_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear speckles	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2277
PMC6078963-41467_2018_5311_MOESM9_ESM.xlsx-PPARD_CHIP_vs_RNA_CD34-PPARD_macrophages_Vs_RNA_CD34_OE_DEGs_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.469431
Saccule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.360224
BRD-K15099225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01922
BRD-K04196669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38322
P4HA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541533
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.9995
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4706
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43652
BRD-K17410712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82756
Regulation of HSF1-mediated heat shock response	Reactome Pathways 2024	1.0	null
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5106
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212599
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249644
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04475
BRD-K97157596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34119
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
cellular response to heat	GO Biological Process Annotations 2025	1.0	null
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
TCS 1102	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
BRD-K88625883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.91244
MKN45_STOMACH	CCLE Cell Line Proteomics	1.0	3.42867
BRD-K28354175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69687
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06152379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18843
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.004
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31252
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CL11	DepMap CRISPR Gene Dependency	1.0	2.2098
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9702
BRD-K27147269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07834
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.854944
EGLN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466811
BRD-K51641263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23532
AB-21-VE32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214834
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8298
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73176613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06891
GSE141624_3_v_6_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K70566686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33967
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50905
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64829
BRD-K23533429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89079
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47052171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59928
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.17717
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
ST8SIA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592974
BRD-K24220535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90604
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
import into nucleus	GO Biological Process Annotations 2023	1.0	null
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2349
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1478
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30464
Testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K75557837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11099
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42392619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74832
BRD-K52175660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03297
beta-thalassemia major	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITM2B-related cerebral amyloid angiopathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.73
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7361
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1142
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Bone leiomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
BRD-K64425085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15623
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84995
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3838
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SR 142948	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44271
BRD-K35108166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67331
Cellular responses to stimuli	Reactome Pathways 2024	1.0	null
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22236
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23445
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89199943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04007
Tooth agenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
Lung bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
SNU1077	DepMap CRISPR Gene Dependency	1.0	2.18677
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214598
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45135
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00374411
MMS22L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15206
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1053
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23357
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09168812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18475
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327001
BRD-A56909893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58039
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
USP39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06351
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4297
BXPC3	DepMap CRISPR Gene Dependency	1.0	2.17834
CLN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24337
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3012
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4536
TBX2-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.38
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54738
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312267
Benzo[a]pyrene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	2.0101
PCI38	DepMap CRISPR Gene Dependency	1.0	2.96949
BRD-K76618080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15853
NCIH441	DepMap CRISPR Gene Dependency	1.0	2.2556
Hypomyelinating leukodystrophy 19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.101
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68045
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258131
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.607123
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K78816149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20336
KP363T	DepMap CRISPR Gene Dependency	1.0	2.64054
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.5147
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7156
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96502
BRD-K35727000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53898
CRCGN015_HEPG2_48H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30375
import into nucleus	GO Biological Process Annotations 2025	1.0	null
Hypomyelinating leukodystrophy 21	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.254
BRD-K06550516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50807
SHP77	DepMap CRISPR Gene Dependency	1.0	2.35708
BRD-K85525164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21056
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326434
FGFR1OP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20518
BRD-K79937734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93818
BRD-K36422663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06069
protein transport	GO Biological Process Annotations 2025	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248843
PRMT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07529
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68314790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3325
BRD-K87640319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42581
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9967
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35296094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59593
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12092
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF311	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31271
BRD-K56650430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07701
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMN-Sm protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.677
BRD-K61366105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21778
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.594173
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7995
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40175
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1522
Disease Exacerbation	DisGeNET Gene-Phenotype Associations	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575026
Clonus	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K92356505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50229
BRD-K78438852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11308
GSE126127_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-71-YF45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23532
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ES8	DepMap CRISPR Gene Dependency	1.0	2.06898
BRD-K71801719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33378
TMP269	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27859
HA1E	DepMap CRISPR Gene Dependency	1.0	2.65989
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05796207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31073
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45289917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46018
PTPN22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608624
BRD-K77869482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20474
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16164
BRD-K44426506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93454
MMAC	DepMap CRISPR Gene Dependency	1.0	2.09216
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560877
Cognitive performance	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
GPATCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00507074
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4803
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.955476
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58387
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.948954
Hypomyelinating leukodystrophy 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.5
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2604
IM95_STOMACH	CCLE Cell Line Proteomics	1.0	4.09626
PMC4539002__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K04095185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18165
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.46039
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT115	DepMap CRISPR Gene Dependency	1.0	2.2149
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
MDST8	DepMap CRISPR Gene Dependency	1.0	2.19517
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.7179
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.638692
Internal capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
BRD-K11667893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43609
GSU	DepMap CRISPR Gene Dependency	1.0	2.27446
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A66369147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69999
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75990394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06609
NCIH2110_LUNG	CCLE Cell Line Proteomics	1.0	2.9861
BRD-K18181387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30876
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.625
protein import into nucleus	GO Biological Process Annotations 2025	1.0	null
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TSPAN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00562522
BRD-K90526956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28961
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585106
NCIH1793_LUNG	CCLE Cell Line Proteomics	1.0	2.1318
SELE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611636
CRCGN015_MCF10A.WT.HP_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05465
BRD-K72933250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.564
BRD-K98695520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90506
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K96164740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10353
BRD-K60862683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2651
cellular response to heat	GO Biological Process Annotations 2023	1.0	null
Orteronel	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
GSE108500_1_v_0_foxp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PACADD165	DepMap CRISPR Gene Dependency	1.0	2.17914
CORO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25023
BRD-K75738997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05149
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02061146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11157
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77993
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5018
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31023
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26987
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_5_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58729
Annulate lamellae	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577706
BRD-K64182862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08726
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00854
BRD-K63401627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13534
BRD-K13673722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00768
Leukodystrophy	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12194
BRD-A69196860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4969
BRD-K00411149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85095
JAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16874
SNU46	DepMap CRISPR Gene Dependency	1.0	2.23926
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02737
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292819
BRD-K69718434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33873
EBF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524406
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20856
BRD-K32208085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73952
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
UPMD1	DepMap CRISPR Gene Dependency	1.0	2.72131
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6693
BRD-K69048559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3243
BRD-K98189856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08883
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11416
BRD-K36566880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09838
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear splicing speckle	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-K23430114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50855
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.46992
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
substance-related disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.869
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5932
APOBEC3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638179
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A37105798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13725
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56385
Krabbe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
BRD-K71007902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82903
496100472_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25075
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17088
BRD-K12709183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07764
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308151
Sulfanilamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9905
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypomyelinating leukodystrophy 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.42
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86454955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8144
neonatal lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451678
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
QA-50-YO37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390051
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CUL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655549
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79103
establishment of protein localization to organelle	GO Biological Process Annotations 2023	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3889
BRD-K13044705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62174
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A29734477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38432
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121959
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.06088
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1_high-signal_selected_bound_promoters_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAX1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41002
BRD-K48372955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87863
GSE210101,GSE210114_11_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PTK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00323667
BRD-K46877890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45215
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90915
BRD-K47175449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00475
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebral amyloid angiopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08836
BRD-K23664196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2592
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373341
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12123029-41598_2025_3625_MOESM1_ESM.pdf-40-SREBF1_SREBF1	Rummagene Transcription Factor Associations 2026	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.56002
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04513
RPE1SS119	DepMap CRISPR Gene Dependency	1.0	2.17791
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22325
GTEx Colon 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	7.05275
BRD-K93219845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05038
GSE157049,GSE157051_6_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.564172
Substance dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.869
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-85-SK26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549115
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.18
CCDC116	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054885
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-905-ZNF655_ZNF655	Rummagene Transcription Factor Associations 2026	1.0	null
BPH1	DepMap CRISPR Gene Dependency	1.0	2.52178
BRD-K76174882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13952
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41969
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34532
SLC43A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23144
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
protein import into nucleus	GO Biological Process Annotations 2023	1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7527
BRD-K66324291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41243
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234125
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1406
POLR2F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30924
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50604
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21793
Eye cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.846185
BRD-K87479423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70929
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08461
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218428
BRD-K20069402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32005
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303031
CRCGN017_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3808
BRD-K09250647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.216
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301728
Hypomyelinating leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.32
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268847
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6891
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.7538
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3551
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
BRD-K70940767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03775
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35923751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09348
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.728515
8218_SNRNP27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500741
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2458
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8386
BRD-K69355244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03985
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7497
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30184
PSMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03514
BRD-K75807882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63823
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
COLO684	DepMap CRISPR Gene Dependency	1.0	2.96701
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406777
BRD-K11674021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15115
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PRSS53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00766391
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15295
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NLS-dependent protein nuclear import complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
BRD-K26503698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00652
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.618783
BRD-K89300187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69035
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186307
BRD-K77246148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17167
Hypomyelinating leukodystrophy 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.411
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.53222
LHCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0072111
BRD-A13210451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2004
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.805175
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307004
Delayed Myelination	DisGeNET Gene-Phenotype Associations	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312013
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310322
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.75924
Brain disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.52934
PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16862492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57725
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KYSE270	DepMap CRISPR Gene Dependency	1.0	2.02013
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1933
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10259
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312044
BRD-K90625171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4173
5902_NUP88_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.53064
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.701825
BRD-K95160020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20309
TRIP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41739
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8034
BRD-K43610632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40524
BD-63-KJ69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264743
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45909830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50615
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33269
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18801549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2167
8462_SSX2IP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509712
BRD-K21996189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69628
BRD-K07939054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02886
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06685815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28538
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6929
BRD-K14863829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00992
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K46890865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40541
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HIKESHI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74803
ZR751	DepMap CRISPR Gene Dependency	1.0	2.17446
Spasticity, Ctcae	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K86240647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65469
Oculodentodigital dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
BRD-K56618252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8356
ZNF480	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27724
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2837
SIRPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502349
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4996
Nystagmus	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37867
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48242
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05006
BRD-K70941976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36301
BRD-K39397248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10172
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36514
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84689
TFF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00659666
Hypomyelinating leukodystrophy 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.448
SLC7A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06467
BRD-K75625428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07387
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3549
BRD-K67261586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42162
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.18
BRD-K51849151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36872
Leukodystrophy	DisGeNET Gene-Disease Associations	1.0	null
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206101
BRD-K56595246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65446
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.942212
BRD-K96624721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84498
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0079
BRD-K93806272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02224
BRD-A21524347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71548
Hereditary spastic paraplegia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
BRD-K43775480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45757
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378651
BRD-K57724549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75844
APBB1IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591722
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06886551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99487
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646884
OCUM1_STOMACH	CCLE Cell Line Proteomics	1.0	3.07068
BRD-K13320013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98784
Spastic quadriplegic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9929
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.8333
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231279
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7666
Hypomyelinating leukodystrophy 24	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.289
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289555
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54016
BRD-K46703028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41051
BRD-K42809349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65816
GSE61117_0_v_1_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.81
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32499
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74908937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75072
EDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056538
BRD-K11457257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68034
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29773
GSE215314_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0962
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SSP25	DepMap CRISPR Gene Dependency	1.0	2.70285
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0433
HPAFII	DepMap CRISPR Gene Dependency	1.0	2.35901
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51566
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein transport	GO Biological Process Annotations 2023	1.0	null
5493_NCBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.564505
BRD-K87465930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10704
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K39600742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05964
nitrogen compound transport	GO Biological Process Annotations 2023	1.0	null
TARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658211
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24913
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23138
BRD-K91516693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3219
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33047
PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72156149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53705
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320109
BRD-K64347765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39285
BRD-K48739735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1724
BRD-K91796483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43958
SPTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00709405
BRD-K28926538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07408
GSE167004_0_v_3_thpo_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BEND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11112
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22783
Cerebrotendinous xanthomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
BRD-A27080191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21561
BRD-K84745303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20941
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7968
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64049
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
3249_GABARAPL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521448
SYT11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522938
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	1.0	1.25399
BRD-K01512588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57308
BRD-K78904317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04697
BRD-K20185935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4035
SLC4A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12274
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74921
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373372
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.707
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74865
GSE101527_3_v_2_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49159670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32638
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
Zellweger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
BRD-A59391763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34819
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Transmembrane actin-associated (TAN) line	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48035
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11254
BRD-K82538319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35374
BRD-K07567566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93745
BRD-K90744477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29468
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.145
BRD-K20426211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58694
BRD-K70050144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1892
BRD-K67531128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76985
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Muscle Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360095
Nuclear pore central transport channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.134
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287917
BRD-K51974360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12233
BRD-K41172555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78882
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.941173
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4361
Hereditary Diffuse Gastric Cancer	DisGeNET Gene-Disease Associations	1.0	null
SPCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44289
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
7585_RTF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.59518
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11424
BRD-K94992087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37706
BRD-K54837058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54891
NICN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15814
IA-76-ZU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366278
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33697018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87644
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
PDXP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03155
TSPAN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34387
BRD-K67725403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08817
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33565
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.63315
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6929
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7129
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67898193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01864
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60458
LF-35-CP32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291779
CRCGN015_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2768
Radicicol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.92
Olodaterol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19039785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09163
Spastic ataxia 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.315
CRCGN012_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10808
Hypogonadotropic hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
HO1U1	DepMap CRISPR Gene Dependency	1.0	2.28771
LC-03-KY64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294138
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223457
BRD-K73290515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00043
496100388_HIP_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0801
ITGAV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00427588
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51876
PMC2813300-pone.0008960.s011.xls-SOX2_targets_in_human_ESCs-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90762344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22947
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.727813
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0
BRD-K07839394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10619
BRD-K91784140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34888
Renal proximal tubule	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0577
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.9833
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487159
Iclaprim	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
ABT-737	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thymus gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3476
QE-48-NG07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334608
Peroxisomal biogenesis disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
No annotation - 6	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81545
PMC3435504-msb201237-s2.xls-Supp_Table_4c-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27416453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32711
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50746465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94501
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393284
SPEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29769
CRCGN013_HEPG2_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43127
Retinoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20107
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276067
BRD-K47283018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24123
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2682
BRD-K17395396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68037
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796854
BRD-K92725027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29411
LS513	DepMap CRISPR Gene Dependency	1.0	2.09397
BRD-K43901257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58327
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377791
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8292
BRD-K70978931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25232
PMC6973177-Table_2.XLSX-LPS_interindividual_differences-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal liver morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2176
Adrenoleukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49995
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43324
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70844489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14704
Alexander disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
BRD-K37892442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49511
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24393110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05215
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9424
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.630598
BRD-K96417480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12434
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371916
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414443
BRD-K70322385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33274
BRD-K14570970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34264
BRD-K89364982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03923
BRD-K77535986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26211
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7456
BRD-K62312047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12206
GD-41-HR28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25788
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23818
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84821804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34003
BRD-K55814495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66393
BRD-K40332193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05255
BRD-K21312826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09371
HCC1143_BREAST	CCLE Cell Line Proteomics	1.0	2.9861
BRD-K00676343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44117
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24769
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.534729
BRD-K36176998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54831
PDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61786
BRD-K47874568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92454
BRD-K01754917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16196
BRD-K15019832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02705
IFT140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22833
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46055
FBXW8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61195
BRD-K07396820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19742
BRD-K24319929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08603
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.640106
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-YY1_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
CP 94253	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8858
LYPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26196
BRD-K08355771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01974
CAMKV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00171
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3023804-pone.0016344.s008.xls-S3_High_Confidence_PPAR_Peaks-Primary_Gene_Name_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
ZDHHC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08179
BRD-K49391713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49635
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHLA57	DepMap CRISPR Gene Dependency	1.0	2.46867
BRD-K13803936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40237
GSE149075_3_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93519076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28788
BRD-K32491833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45874
BRD-K79908599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46764
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5311
CRCGN008_HEPG2_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46505
ZNF410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6884
BRD-K71807663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17359
SHCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47252
BRD-K43324262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49115
Spondyloepimetaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
Prostate small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38048
AA-80-XK94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433497
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1766
BRD-K16154498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48548
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1175
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
U118MG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	5.38822
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227062
PMC8423434-mmc7.xlsx-OCT4_Primed-Genes_n_912_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61087440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34628
GSE183271_5_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17845
TFIP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02885
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
956_HIKESHI_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.9377
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.9742
Stress response complex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
CD300LG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710307
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tay-Sachs disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9192
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2123
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18368
SLC25A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37365
BRD-K55144248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.226
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2383
BRD-K71184289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63611
BRD-K19579217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45178
NCIH1355	DepMap CRISPR Gene Dependency	1.0	3.05183
BRD-K18515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89569
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229455
BRD-K86228587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93506
BRD-K85162983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95101
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480714
Walker-Warburg syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
Cellular responses to stress	Reactome Pathways 2024	1.0	null
PLCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00669
CCLFUPGI0005T	DepMap CRISPR Gene Dependency	1.0	2.07421
TMC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480893
BRD-K75909618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75097
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8969
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1262
PRPS1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602562
BRD-K75168124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29004
BRD-K10634221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68553
BRD-K88964321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00332
BRD-K50941200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02924
BRD-K46001734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30738
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular protein transport	GO Biological Process Annotations 2025	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228744
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.3682
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10176883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32299
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6686
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07762528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87866
SB-224289	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.71
BRD-K36474885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3227
BRD-K91712163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66014
BRD-K82244940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31192
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70004
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489278
BRD-K57476199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5581
GZMM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503738
BRD-K30252238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11528
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-63-LW25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265289
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266192
IL7R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637124
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K56716645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37195
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11838
BRD-K99522349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84575
IGR1	DepMap CRISPR Gene Dependency	1.0	2.52678
BRD-K72549552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0274
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5174
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38853406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5171
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K02671211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18239
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12183081-41388_2025_3375_MOESM8_ESM.xlsx-Sheet1-Table_S7_List_of_differentially_alternative_splicing_genes_in_osteosarcoma_cell_lines_after_knocking_down_the_YBX1_gene_P_0_05_Related_to_Fig_6C_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67703
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97434
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CENPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1632
Hypomyelinating leukodystrophy 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.342
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27578003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3358
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32638
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K59134599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01385
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Costunolide_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019604
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1355
BRD-K58791506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35895
BRD-K71216961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01424
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235383
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195568_1_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457509
Apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
GSE151782_4_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.503644
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6884
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0139
CRCGN008_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70085
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0637
BRD-K41396351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5045
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76968
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.886108
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5654
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59778279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08072
KRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0044293
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
Hereditary spastic paraplegia 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
MRPS34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10885
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35936
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5493
BRD-K08359838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20367
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
establishment of protein localization to organelle	GO Biological Process Annotations 2025	1.0	null
Leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.075
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02576
TRIM54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14782
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26358
BRD-K92565319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18777
BRD-K04251837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21576
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60543885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84571
BRD-K83477969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02758
BRD-K48029682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.369
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72317601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73944
BRD-K68741898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06111
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7993
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tetrindole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
CHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00396
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K56373119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01442
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
DCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89635
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86104966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45334
GPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54958
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08123
ED-32-VE54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29268
BRD-K64026092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22948
BRD-K01774461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.359
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19101
TMEM106C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07394
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3983
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20285
BRD-A22502911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33859
BRD-K96776591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05739
BRD-K67126097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47372
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE30	DepMap CRISPR Gene Dependency	1.0	2.52318
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
NFILZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27165
BRD-K82112239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30147
Hypomyelinating leukoencephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.752
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284463
HCC827_LUNG	CCLE Cell Line Proteomics	1.0	7.54947
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15697
BRD-K15322427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93787
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.75735
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304719
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06311
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.639818
BRD-K33453127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58348
Hypomyelinating leukodystrophy 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.47
Protein N-acetylglucosaminyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.718
BRD-K32082369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62317
BRD-K49409924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8357
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.951245
SR 3335	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536137
DNMT3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68802
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519119
Clara cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
CRCGN015_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1963
PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14001
BRD-K86070914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40764
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9065_DMAC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.528251
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EF-85-DA07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226884
BRD-K82823857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02136
GSE153757,GSE153758_0_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4869
PMC3023804-pone.0016344.s008.xls-S3_High_Confidence_PPAR_Peaks-Primary_Gene_ID_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
STX11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689168
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87144
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0949
CRCGN014_HEPG2_3H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01424
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482207
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15192
BRD-K68347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0256
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232583
BRD-K73177528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49354
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3574
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57059
PMC8322331-41598_2021_94805_MOESM3_ESM.xlsx-b_STAT3_UP_assoc_transcripts-Gene_Name_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26024910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50782
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
BRD-K05444553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01405
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2398
pravadoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76114
CRCGN015_MCF10A.TP53.M_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08754
BRD-K13973870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36852
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Absent Speech	DisGeNET Gene-Phenotype Associations	1.0	null
Hypomyelinating leukodystrophy 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
abnormal club cell morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K83786559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30329
BRD-K32402344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23326
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1879
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.31013
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.71889
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75775113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.566
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_SIX5-gene_SIX5	Rummagene Transcription Factor Associations 2026	1.0	null
RGS13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689741
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.1992
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP3K14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58843
protein localization to nucleus	GO Biological Process Annotations 2023	1.0	null
BRD-K52468958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2503
SCH	DepMap CRISPR Gene Dependency	1.0	2.22553
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6378
AA-87-EI21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334314
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24229
BRD-K07281036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46311
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
prenatal lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K40760168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67337
abnormal lung development	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94735
BRD-K05639803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79815
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3803
BRD-K68083867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02438
BRD-K28545166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65682
Hsp70 protein binding	GO Molecular Function Annotations 2025	1.0	null
Cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05321
BRD-K29936219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07986
Cannabis dependence	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.869
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6611
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rab9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54622858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15261
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5537
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199056
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6236
OSC19	DepMap CRISPR Gene Dependency	1.0	2.01927
BRD-A70099008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5246
Teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K45134469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06186
COLO679	DepMap CRISPR Gene Dependency	1.0	2.39767
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07805
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34282646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10357
BRD-K53797069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9771
BRD-K32403948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05109
BRD-K71893034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40755
BRD-K03309398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10146
exon-exon junction subcomplex mago-y14	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
JVE015	DepMap CRISPR Gene Dependency	1.0	2.54931
BRD-K50477983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23616
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80965
BRD-K84874502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91635
SCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14647
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05813
Xanthomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354898
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2695
LA-42-CN75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386918
BRD-K37336973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44119
BRD-K34232791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39229
Extrachromosomal rDNA circle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.55
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80639
BRD-K61092554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0716
GD-69-GP37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335909
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13867
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492268
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2082
SAS	DepMap CRISPR Gene Dependency	1.0	2.53952
BC-72-DZ30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203961
BRD-K06459664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00424
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0842
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-76-FL46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329253
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61681
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2804
PMC3435504-msb201237-s2.xls-Supp_Table_4b-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
Alabastrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.495
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3409
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.111
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
MRPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34013
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259831
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84310612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00178
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15876355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21341
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2789
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC25A44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10241
Generalized Hypotonia	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN015_HEPG2_48H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18087
Metachromatic leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31546068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36004
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1463
BRD-K70537701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46858
IL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609341
BRD-K06997715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09258
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50614
STAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00483038
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506618
Hypomyelinating leukodystrophy	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3058
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.025
AB-10-RE65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.851515
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.121
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147240_3_v_1_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45013226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72494
CE-18-AP15_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420685
8100_SLC52A2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547965
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.536959
BRD-K75220555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01603
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227486
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chromosome 18q deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
TMEM45A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536499
BRD-K93486666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13536
BRD-K52225720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29317
BRD-K32617235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43224
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-228357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05066
BRD-K61033092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55102
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5905
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CF-97-KZ12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259005
PCWH syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.641
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.988083
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27248268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41589
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.709
TGFB1I1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477384
BRD-K34311186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0167
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6711
PMC3076323-pone.0018064.s016.xls-MYCN_targets_Marson_GSE6007-Unnamed_1_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
abnormal liver morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03666
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9212
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
PROCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07408
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.593578
Failure To Thrive	DisGeNET Gene-Disease Associations	1.0	null
K562_BMS-536924_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224655
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE410	DepMap CRISPR Gene Dependency	1.0	2.444
HEC251_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.30083
BRD-K24143478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08278
BRD-K18635665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00517
Pomalidomide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
BRD-K82814367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24444
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08297
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462961
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233284
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
HTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09708
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34033
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67014046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20438
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456433
BRD-K10317744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09079
BRD-K05000526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51552
Sphingolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
KIRREL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065813
Cerebral degeneration	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
CAL51_BREAST	CCLE Cell Line Proteomics	1.0	3.241
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35188988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47292
496100456_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50951
Medial longitudinal fasciculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
Bardet-Biedl syndrome 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cestode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.998414
BRD-A31576716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02564
BRD-K45959036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5398
BRD-K39573478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91191
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45203
SNU601	DepMap CRISPR Gene Dependency	1.0	2.4563
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48143921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61947
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45439
BRD-K45077605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00538
BRD-K62324460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02569
CRCGN016_MCF10A.WT.HP_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06147
BRD-K20245846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11833
LE-80-QM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331584
Spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
BRD-K92432769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27393
SREK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00743007
ASTE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68581
CRCGN015_MCF10A_48H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27325
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3128
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RNF112	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588089
hTERT-HPNE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
BRD-K54370483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12603
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268341
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47271260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6145
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
ANO8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31429
BRD-A94698726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05692
BRD-K69031148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01404
RBM12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69398
BRD-K95875837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25869
BRD-K17315445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36706
Nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.768
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34769
PAQR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8187
BRD-K44834268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18703
BRD-K17285268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15102
BRD-K29662589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09341
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.904704
HS852T	DepMap CRISPR Gene Dependency	1.0	2.06056
PMC4539002__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15361
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63960902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1918
MFE296	DepMap CRISPR Gene Dependency	1.0	3.01293
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6721
BRD-K65789952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92196