association	dataset	threshold value	standardized value
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.07983
A549_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170214
HMGB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59602
BRD-K52932858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42966
GTEX-XAJ8-0526-SM-47JYK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54985
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251458
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4995-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XUZC-0526-SM-4BOPF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PF-84-RH50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21114
RELA_01_80	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67554
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12958
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CAKI1	DepMap CRISPR Gene Dependency	1.0	4.89435
Trametinib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0158111
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.4107
ADAMTS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64832
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164458
Sonidegib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190559
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.835261
SRSF11	Pathway Commons Protein-Protein Interactions	1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61223
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5
CCRF-HSB-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
ONECUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38701
DDX53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27041
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43064
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883562
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871598
A549_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145546
felbinac-3398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
mRNA_RHOX6_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Azithromycin (hydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221162
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0261102
BRD-K64827406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9138
Ruboxistaurin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.75
BRD-K88495921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6657
g8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.384
TMEM167A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56988
SMAD4-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
UFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38634
ASPC1	CCLE Cell Line Gene Expression Profiles	1.0	1.71227
PLCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11083
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4581_KO_Carm1_SRP135904	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.87108
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165307_2_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33341
Perturb_3780_KD_POLR2D_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GATA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54697
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59862
CHEMBL:CHEMBL592124	DGIdb Drug Targets 2026	1.0	0.131345
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831427
hsa-miR-320d	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3837_KO_ING3_SRP304782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RPL26	Pathway Commons Protein-Protein Interactions	1.0	null
LIN28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60968
Naproxen_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0330334
GSE128730_7_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.69
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	1.0	null
pyruvate metabolic process	GO Biological Process Annotations 2025	1.0	null
OVCA433	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.87988
Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13636
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156395
BRD-K37176385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67627
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
hexose metabolic process	GO Biological Process Annotations 2025	1.0	null
MGAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36072
A549_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153719
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8176-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-1626-SM-3NB21	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882679
KDM4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04613
GPRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47033
GSE134375_0_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016605
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68688
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
95T1000	DepMap CRISPR Gene Dependency	1.0	2.52274
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95218
Salicylic acid_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255852
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243926
GTEX-P78B-0526-SM-2I5F7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28203
lateral part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85164
Mitochondrial creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Belumosudil (mesylate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265437
TE-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_5959_KD_RPF2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.88937
C1orf115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76829
XRK3F2_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268723
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MSH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58324
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55319
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.875633
ADD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29314
EIF4H	Pathway Commons Protein-Protein Interactions	1.0	null
small intestine	GTEx Tissue Gene Expression Profiles	1.0	1.45911
BRD-K24689407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18869
BRD-K05015930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96504
ZSWIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41537
Triamcinolone_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296871
ME2	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3762
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HA7-RCC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CNIH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40134
SEMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05634
ECC4	DepMap CRISPR Gene Dependency	1.0	2.11747
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
CAPAN-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23717
BRD-K62707745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23713
JUND	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.951624
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323607
GEMIN5	Pathway Commons Protein-Protein Interactions	1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2393
ZSCAN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87155
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241829
ACTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49671
CAL120	CCLE Cell Line Gene CNV Profiles	1.0	1.42909
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70678
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18757
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58171
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brimonidine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0344676
AKAP17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64976
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20848
UQCRFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92574
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-O5YT-0226-SM-32PK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Lidocaine (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0359244
CJ-42794	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
RGS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03144
Mesothelioma_MESO_TCGA-LK-A4O2-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73562260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43496
hsa-miR-3136-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE226770_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PNPLA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48006
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5302
YTHDF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86951121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20118
MRPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92579
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41954
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21868
BRD-K57184082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77926
placenta	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53329
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.871274
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.48371
GTEX-QLQ7-1826-SM-2S1R5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944666
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KIAA1143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43794
KHDRBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41066
layer 1 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04483
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01562
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43007
Ispinesib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.79
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9013
CHD1	ENCODE Transcription Factor Targets	1.0	null
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-13_CD7_CD1a_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22063616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07636
Perturb_8377_KD_MAGEA3_ERP120445	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC8208823-mmc2.xlsx-CDX2-KO_epithelial_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
preopto-hypothalamic band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51998
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
FZD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80795
BRD-A20208638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30187
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18382
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30446
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23374
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.735
Stat5a::Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4712
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20958
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.288
BRD-K12705251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0962
Brain Lower Grade Glioma_LGG_TCGA-F6-A8O3-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Anterior cingulate area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17613
Irinotecan_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.025257
Delamanid_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298995
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.31929
ANGPTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43597
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43788
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23874
Ivabradine (hydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237531
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3492
GTEX-NPJ7-1726-SM-2YUNA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856697
glucose 6-phosphate metabolic process	GO Biological Process Annotations 2025	1.0	null
9-ING-41_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264953
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.5975
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135288
A549_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157831
HK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81977
Cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
CACNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sodium Salicylate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106203
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6714
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060367
SNRNP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69059
ZNF543	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43003
HIST1H1C	Pathway Commons Protein-Protein Interactions	1.0	null
496100529_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.7236
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.92588
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.825115
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09736
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955532
DHX38	Pathway Commons Protein-Protein Interactions	1.0	null
TMED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62243
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956272
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2053
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23535862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16673
NUGC-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.59925
BRD-K85362541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4935
BRD-K29519734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2741
Perturb_11219_KO_SMYD3_SRP396801	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53389
CDX2	ChEA Transcription Factor Targets	1.0	null
CRCGN015_MCF10A_48H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41009
MYO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02873
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30858
Glycyrrhizic acid_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166979
CRLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7971
Brimonidine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243242
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDX2-20551321-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
ATF2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Aspirin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00903702
GTEX-XPVG-2826-SM-4B66J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970291
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29567
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62087
Dabrafenib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0655103
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3684_KD_MEX3A_SRP321087	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156613
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115793
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWCY-0926-SM-48TD7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
Flutamide_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250556
ChIP_REST_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE145249_0_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15007
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57425
GSE189356_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUZC-0126-SM-4BOO6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00141
Trametinib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162356
JIYOYEP-2003	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29241
Ethoxzolamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.63
18949382-Table3	GeneSigDB Published Gene Signatures	1.0	null
Folic acid_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0328023
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18817
Gallic acid (hydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00507124
Small_Intestine-intestinal crypt stem cell of small intestine	Tabula Sapiens Gene-Cell Associations	1.0	0.778831
GFUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30239
glycolytic process	GO Biological Process Annotations 2015	1.0	null
Tolmetin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0310919
ZNF621	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24017
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YP-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.43263
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45142472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16914
vincristine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0705543
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.965
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SPAG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12001
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16019
BRD-K83090041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1094
MDA-MB-231	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
THUMPD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-POMQ-2026-SM-2S1OD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0746
BRD-K71622214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54084
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05754
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869364
BRD-K86448296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3784
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-2.06
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CCHCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19446
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855823
B3GNT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79999
A549_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141913
NCIH526	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
layer 2 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39863
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17796
CLIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06341
Lung adenocarcinoma_LUAD_TCGA-55-8505-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M6PR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28552
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
transferase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K68458302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04798
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45022385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4448
TRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12982
A549_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121635
Perturb_7877_KD_NFYB_SRP264849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
MAD2L1BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41738
Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.212612
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-FOXP3_mod_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8179
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36367
BRD-K24396733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03522
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	3.77588
APTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87012
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
DNAH1	Pathway Commons Protein-Protein Interactions	1.0	null
upper basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97058
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EHHADH	Pathway Commons Protein-Protein Interactions	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4866-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIWIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04908
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Tadalafil_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0227669
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09584
YH13	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73141
Afatinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202423
Brain Diseases	CTD Gene-Disease Associations	1.0	1.10353
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7638
venetoclax_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0198905
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glucosamine	HMDB Metabolites of Enzymes	1.0	null
BRD-K27121064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79425
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
FGF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61369
Ventral tegmental area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27706
MEOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15308
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43483
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58568
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29844
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7473
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Everolimus_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0491102
AZD-7648_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205393
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
Small intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_6850_OE_ZNF37A_SRP273660	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.8485
TAF5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03037
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab6_KDM5C-KD-up_genes-Table_6_Up_regulated_genes_in_KDM5C-KD_KDM5C-KD1_Control_overlap_KDM5C-KD2_Control_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03253
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer SZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845164
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96022
Proglumide_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196966
Perturb_6705_KD_NHERF2_SRP057199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.64117
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.99299
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94791
Ipatasertib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260559
BRD-K54332480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04613
LUC7L2	Pathway Commons Protein-Protein Interactions	1.0	null
Ornidazole_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0346506
ZNF394	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0985
DECR1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SENNOSIDE B	DGIdb Drug Targets 2026	1.0	0.254481
NCIH460_LUNG	CCLE Cell Line Proteomics	1.0	2.17502
Terfenadine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250098
SLC25A19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27732
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252932
hsa-miR-488	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K07011015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52652
KAT2B	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60078
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.912394
BRD-K78907463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39817
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
hexokinase activity	GO Molecular Function Annotations 2015	1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-POMQ-0526-SM-3GADD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17025
MCMBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64259
Megestrol_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240552
ADM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27698
TCF12	ENCODE Transcription Factor Targets	1.0	null
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.069567
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8511
Retinoic acid_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0241383
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.93137
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.226
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X8HC-0726-SM-46MWG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83935
Brivudine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0376253
SRRT	Pathway Commons Protein-Protein Interactions	1.0	null
MK-8353_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0318389
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44652
PRR14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67217
C75	DepMap CRISPR Gene Dependency	1.0	2.33532
BRD-K66748326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90982
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Retinoic acid_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282147
GNG14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14554
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.985613
L-6 myoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
Sulfisoxazole_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0272699
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0323127
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K94582731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0129
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.382
Spliceosomal tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13044
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HK2	CCLE Cell Line Gene Expression Profiles	1.0	2.16613
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60758
ZNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89731
GTEX-WFG7-1626-SM-4LVMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Anteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1774
memantine-2934	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lactate (calcium)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0133637
MKN45	GDSC Cell Line Gene Expression Profiles	1.0	2.11335
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49694
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-ATF2_UP_V1_DN-Ensemble_gene_ID_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
Posterior parietal association areas, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0422
Berbamine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0289153
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
BT549	DepMap CRISPR Gene Dependency	1.0	2.03102
diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.133102
EZH2-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Retinal disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
SP1_01_81	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.40211
BRD-K98953346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63139
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.853215
BRD-K81447429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51737
BRD-K97468369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08491
BRD-K34957967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47319
Tubulin inhibitor 6_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0332363
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18822
attention deficit hyperactivity disorder	GWASdb SNP-Phenotype Associations	1.0	0.699367
GSE70499_5_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132759_4_v_2_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7431913-Table_1.xls-Sheet1-TablesS1_Gene_clusters_highly_co-expressed_with_MNX1_MNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A710-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-PWCY-0226-SM-48TD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
GTEX-OHPL-2426-SM-48TDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
Epirubicin (hydrochloride)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113764
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138085
Lumateperone (tosylate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0303847
HDDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84623
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09857
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
phosphotransferase activity, alcohol group as acceptor	GO Molecular Function Annotations 2015	1.0	null
GTEX-O5YT-1426-SM-3MJHC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28908
progesterone_homo sapiens_gpl570_gse29437	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pyruvate metabolic process	GO Biological Process Annotations 2023	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33063
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893319
A549_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00729743
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16569
PCSK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31487
LRRC42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2123
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
A549_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290894
ES7	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.77892
BTN3A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58781
SARS-CoV_24Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.36753
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37755
LY-2584702 (tosylate salt)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0223591
plasma	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05455
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261899
HMGB3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38705
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039766
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071599
Pi Mi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
Lung adenocarcinoma_LUAD_TCGA-44-6145-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Talc_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0228613
lateral preoptic area, PO1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43002
LIMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77262
JHOS-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NFATC2IP	Pathway Commons Protein-Protein Interactions	1.0	null
NMS-873	DeepCoverMOA Drug Mechanisms of Action	1.0	2.0
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015275
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0726-SM-3GADX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828483
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20165
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3347-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6378_KD_lncRNAHUMT_SRP326145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hsa-miR-3691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
lower basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.44554
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.857975
Dihydroartemisinin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0486091
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AH-0926-SM-48TZK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931173
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08134
NEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98339
H1FX	Pathway Commons Protein-Protein Interactions	1.0	null
Teijin compound 1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
A549_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117944
NUMBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33373
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159748
ACOT9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20847739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28795
HCC2998	BioGPS Cell Line Gene Expression Profiles	1.0	1.27101
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250782
KYSE-520	GDSC Cell Line Gene Expression Profiles	1.0	1.64557
SNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08996
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
CAKI1	CCLE Cell Line Gene Expression Profiles	1.0	1.54361
KP3	CCLE Cell Line Gene Expression Profiles	1.0	2.65243
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K42480393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69738
GTEX-R53T-0526-SM-3GADL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870597
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5-Azacytidine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0247754
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC10A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87348
Perturb_7666_KD_IMP1_DRP003316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.81289
Perturb_15410_KD_GATA2_SRP043960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57997
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
KMT2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80081
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38589
TBC1D7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80365
GTEX-OIZH-1426-SM-3NB1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37713
Perikaryon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9911
PLEKHA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23718
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48754
PDE12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05372
PEBP1_KO_GDS4334_617_mouse_Pancreatic beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XBED-1326-SM-4AT4F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
REST-18959480-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235133
Pimitespib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0407719
EIF2S3	Pathway Commons Protein-Protein Interactions	1.0	null
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01866
OC-314	GDSC Cell Line Gene Expression Profiles	1.0	1.4249
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Penfluridol_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0239385
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164919
A549_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265238
hsa-miR-628-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
WM115	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57851
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
HOXD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.12742
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09021
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13003
phosphate-containing compound metabolic process	GO Biological Process Annotations 2023	1.0	null
AMOTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38377
smallintestine_4d	HPA Tissue Sample Gene Expression Profiles	1.0	1.4599
Capmatinib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161217
UQCRH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5788
PMC10929187-ijbsv20p1547s3.xlsx-XBP1-dependent_genes-AARS_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
PRRC2A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHSB-2026-SM-3LK6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14718
TEAD4	ENCODE Transcription Factor Targets	1.0	null
VARS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_5005_OE_Mnx1_ERP140947	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.21355
Paclitaxel_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233887
MIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25054
PDGFRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81725
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.027656
Sulforaphane	DeepCoverMOA Drug Mechanisms of Action	1.0	1.08
JUN	ENCODE Transcription Factor Targets	1.0	null
MAD2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.4586
TSC22D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69558
CHEMBL:CHEMBL1865517	DGIdb Drug Targets 2026	1.0	4.07169
BRD-K52595962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66612
PMC6360815-supp_gr.239053.118_Supplemental_Table_S2.xlsx-MAFs_targets-Table_of_potential_MAF_targets_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.419
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61172
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5514
PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-Proximal_Tubule_Enriched_Genes_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K92941354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17918
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0631
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ZNF787	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-TM_KO_vs_WT-Supplementary_Table_S2-2_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_TM_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
carbohydrate kinase activity	GO Molecular Function Annotations 2015	1.0	null
ECSCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60599
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13249
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88960810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21834
NR4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07529
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
submammillothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96833
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92138
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49113
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06086
Retrosplenial area, lateral agranular part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27694
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
posteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1861
GSE205070_1_v_4_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1A_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14013
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IGF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12623
Tubastatin A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4827-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4038464__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60268
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.915569
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BxPC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41791
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Fructose galactose metabolism	PANTHER Pathways	1.0	null
BRD-K13515483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61387
TMEM185B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48022
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
ATF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16754
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861093
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456313
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31223
BRD-K79619334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14822
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00411
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6217
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81704
Pentagastrin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210375
L-Eflornithine (monohydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0178284
PMC7217064-IJC-146-3354-s004.xlsx-Table_S5-Supplementary_Table_S5_Genes_significantly_upregulated_in_OC2-transfected_AGS_cell_compared_to_control_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8851354-Table_2.xlsx-Genes_reg_by_FUS-DDIT3-Supplementary_Table_2_Genes_significantly_regulated_by_FUS-DDIT3_expression_in_HT1080_cells_adjusted_p-value_0_05_and_log2_Fold_change_1_or_-1_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84478344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1549
TRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34052
GABRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52313
Fasting Blood Sugar Result	DisGeNET Gene-Phenotype Associations	1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dihydroartemisinin_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0234762
Perturb_6752_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99901
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal dominant nonsyndromic deafness 78	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.714
Perturb_18438_KD_NR2F2_ERP124128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8745
Mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Trifluridine_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237802
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DGKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0668
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.894433
FSCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83757
KNS81	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37251
BEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01618
COG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95034
ZFP41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69302
BRD-K47510632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35734
EZH2-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pexidartinib (hydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250443
Fostamatinib (disodium hexahydrate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0235504
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.0494
Perturb_14364_KD_SCD_SRP352005	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
KMM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35191
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PDLIM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59669
Ovary	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.15
U2AF1L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06644
BRD-K87879912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42928
TRPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10458
CKLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32368
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LY2090314_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00988296
ricinine-6067	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152797
Futibatinib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0339812
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OSGEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54554
RBM10	Pathway Commons Protein-Protein Interactions	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64528
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64597663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33981
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.85
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9257
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.836462
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Oxaliplatin_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0457177
DT-061_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0426954
RD	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19452
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
BI-3406_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0129336
BRD-K04771555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29129
Sivelestat (sodium tetrahydrate)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270445
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19941
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17662
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80517
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98805845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28408
Pimitespib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0104556
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3889
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
PRCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08832
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
DIABLO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2478
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.531
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86729
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46541
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868626
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54222
GSE201217_3_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE249544,GSE249637_9_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MO-0426-SM-32QOI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865001
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41355
RD_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.29275
Vitamin K4_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122476
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
upper basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31233
ERCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96601
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
macelignan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38079
RRP12	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Darinaparsin_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204562
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.950542
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.12834
GTEX-OHPK-2626-SM-2HMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13047
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.235
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.916053
LSM1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
A549_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019368
G-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K40248932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66705
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013915
PLCPRF5	DepMap CRISPR Gene Dependency	1.0	10.4804
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Goserelin (acetate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0289067
RUNX1T1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82772
FOSL1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLDN1_OE_GDS3510_31_human_CL1-5 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K73463737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38447
A549_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199033
HS2ST1	Pathway Commons Protein-Protein Interactions	1.0	null
ME-180	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.82941
Fatty Liver	CTD Gene-Disease Associations	1.0	1.92801
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4712-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.896928
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208662
SERINC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59355
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
DNAJC9	Pathway Commons Protein-Protein Interactions	1.0	null
SK-HEP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_12234_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.9586
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
DPY19L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22615
LRRC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52963
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1508
ZNF736	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66097
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HECA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26637
TCEA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70216
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59128
Retinitis pigmentosa	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09412
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933379
POU2F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72606
HMMR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26678
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
Trametinib_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216797
Vandetanib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182089
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70945
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.91
EMG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREBBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30069
VAMP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38192
TRAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05318
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A60K-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20108
NAGPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1724
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5226
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Homoharringtonine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0422556
TK10	GDSC Cell Line Gene Expression Profiles	1.0	1.68185
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6951-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97369
BRD-K83783925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21602
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFPI	Pathway Commons Protein-Protein Interactions	1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
anion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K47417426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14702
GSE249544,GSE249637_8_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZDHHC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08648
Lung squamous cell carcinoma_LUSC_TCGA-90-7964-01A-21R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DHX29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45078
Encorafenib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0395606
HEC-1-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Anterior cingulate area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54439
Docetaxel_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106221
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.06981
GTEX-R55G-1126-SM-48FDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.40036
BRD-K65729622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71362
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183606
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20255
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Riluzole hydrochloride_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321333
BRD-K49673270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41985
A549_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166625
PUS7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28472865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48176
Primary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17929
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927904
HSP90AA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33833
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5907-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SART1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60376
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
Perturb_5211_KO_Pten_SRP154291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.5633
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144422
FAM98B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64885
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43064
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99302
GTEX-OIZI-0426-SM-2XCEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14815
gdm1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.136
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3506
SLC35B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3541
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBM42	Pathway Commons Protein-Protein Interactions	1.0	null
SPNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73966
preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11623
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1_02_157	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.90689
CUL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44457
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33447
GOTO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.027774
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
AZD-7648_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0392788
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.904085
PSPC1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07012
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51128
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Secondary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38978
Perturb_8068_KD_NONO_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.4759
Procainamide (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0259412
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
associations	GeneRIF Biological Term Annotations	1.0	null
Autosomal Recessive Retinitis Pigmentosa	DisGeNET Gene-Disease Associations	1.0	null
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00943401
SLC12A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16258
BRD-K24443173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79571
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18657
TAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44733
BRD-K56401968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40628
PPP1R11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64414
GTEX-XQ3S-1726-SM-4BOOD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-Q2AH-1226-SM-48TZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41427
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05431
hippocampus (hippocampal formation)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07224
ARFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94123
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29978
BRD-K22679163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45282
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.97464
Lung adenocarcinoma_LUAD_TCGA-91-6830-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.29646
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827442
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64029
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.828751
SMAD4_01_250	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.90116
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37359
Perturb_15747_KO_Cnga1_SRP327351	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.6383
Photoreceptor outer segment membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856894
Primary visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42491
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33904
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51761
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.578266
BRD-K55946794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1331
PCDH18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03895
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08159
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36875
BRD-K12397820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15225
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
palbociclib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271251
Perturb_224_KD_YBX3_SRP289565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.64024
callosal sling	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.950392
GTEX-NFK9-0426-SM-2YUNK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955035
Irinotecan (hydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0280935
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24261
Elagolix sodium_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113499
GTEX-S3XE-0326-SM-4AD6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826004
PEG3	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
MICU1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20364
BRD-K66016089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65344
REST-18959480-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC6122955-elife-33947-supp2.xlsx-HNF1A_activated_survival-HNF1A-upregulated_genes_association_between_gene_expression_and_survival_in_TCGA_PAAD_tumors_-_related_to_Figure_7-figure_supplement_1A_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59100858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75914
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205332_2_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3779_KD_NFYA_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ACHN	BioGPS Cell Line Gene Expression Profiles	1.0	1.43208
duodenum_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.25706
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43855
BRD-K59250830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6521
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13785
BEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88849
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
attention deficit hyperactivity disorder	GWASdb SNP-Disease Associations	1.0	0.803614
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63491
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09993
GTEX-X5EB-1626-SM-4E3IV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60876
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55467
MBD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10047
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Retinal degeneration	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
SPI1	ENCODE Transcription Factor Targets	1.0	null
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
JVE015	DepMap CRISPR Gene Dependency	1.0	2.31998
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Metabolism of carbohydrates	Reactome Pathways 2024	1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2015
Steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
BRD-K69337311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51438
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61687409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44638
STC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52319
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.84769
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KH-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF122	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01127
GTEX-V955-2526-SM-4JBJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17354
thin retina outer nuclear layer	MGI Mouse Phenotype Associations 2023	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.14879
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97576
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067258
PMC6122955-elife-33947-supp2.xlsx-NY8_and_NY15_HNF1A_binding-HNF1A_binding_status_for_genes_differentially_expressed_in_NY8_and_NY15_cells_-_related_to_Figure_7B_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55562948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07102
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9812
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26694226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31769
Visual areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3255
Thyroid Diseases	CTD Gene-Disease Associations	1.0	1.05573
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62206
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13755
OSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30401
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.346
Tubulin inhibitor 6_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264453
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CG-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53818
acepromazine-4494	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33335
OCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68416
Perturb_11504_KD_TOLLIP_SRP312714	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.922402
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF3D	Pathway Commons Protein-Protein Interactions	1.0	null
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.794899
A549_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186034
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.438494
Rkip1_KO_GDS4331_15_mouse_C57BL/C pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.15189
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845208
HCC1954_BREAST	CCLE Cell Line Proteomics	1.0	3.15513
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80006
ERLEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63428
A549_JQ1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120908
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828746
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.903225
DTP3_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262214
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142041
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275916
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.96245
pallidal islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23025
NNAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82962
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840094
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.967448
TRIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29411
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.830374
BRD-K71778797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44368
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
eye	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
COLO-205	GDSC Cell Line Gene Expression Profiles	1.0	1.65753
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dihydroartemisinin	DeepCoverMOA Drug Mechanisms of Action	1.0	1.53
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
STAT1-17558387-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GATA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18698
MYB-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2H	Pathway Commons Protein-Protein Interactions	1.0	null
MK-8353_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.033819
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Captopril_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0328331
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.587291
STXBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76304
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
glucokinase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-U3ZN-0626-SM-3DB7U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00769
Rhinencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
BRD-K91624805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80378
BRD-K12607407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41332
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42212
Ribociclib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0327462
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58328
BRD-K67348226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69023
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890408
Acetate CoA-transferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.833
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26918
Belzutifan_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0285666
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Elimusertib hydrochloride_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234026
REST-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853647
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stem leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
BRD-K26026745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14163
homeostatic process	GO Biological Process Annotations 2015	1.0	null
Perturb_5338_KO_Haunt_SRP044012	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.17849
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.905866
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23427
BRD-K34910830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63449
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PANO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81654
Aliskiren_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238421
hsa-miR-876-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUN-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21268
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14181
SMU1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PC3	CCLE Cell Line Gene CNV Profiles	1.0	1.95945
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.71701
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24495
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.57571
EJM	DepMap CRISPR Gene Dependency	1.0	4.34565
Norepinephrine (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264438
Fedratinib (hydrochloride hydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0433965
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
A172	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.02481
GTEX-R55C-1126-SM-48FCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00602
Brain Lower Grade Glioma_LGG_TCGA-TM-A84G-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7480-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.54429
A549_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145414
SKMEL3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38215
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.891613
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87537204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.05232
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
SPAG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14423
IGR39	DepMap CRISPR Gene Dependency	1.0	2.04694
Retrosplenial area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10761
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
p2 portion of the parabrachial pigmented nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55533
flurbiprofen-5634	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE207301,GSE207303_1_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zileuton_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0363011
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_REST_18959480	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TFB2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82784
CRCGN008_HEPG2_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14005
GSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87494
DETROIT562_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.01533
chemical homeostasis	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5870-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00997
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
OVISE	CCLE Cell Line Gene CNV Profiles	1.0	1.59418
Sigmoid_Colon	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.867033
EIF2S2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K55256232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1024
THRAP3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.409939
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868511
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
cyproterone-4470	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-2117	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
SEPTIN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31886
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A76W-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAD1	Pathway Commons Protein-Protein Interactions	1.0	null
Gravid adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.295
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U4-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IL2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7284-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25289
BRD-K11715561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67027
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF322	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42377
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04377
CHP-212	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925684
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
BRD-K59491389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14763
CD276	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89985
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4857-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.82343
Pamidronic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
mantle zone of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11848
MPZL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.388
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11236
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.023
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865945
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT1_KD_vs_SCR-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17907
CRCGN015_MCF10A.TP53.M_24H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46185
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23036
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11956
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30125
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8412
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D2REFED4h_641_AR-D-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46971
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.95066
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.979062
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836878
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3697
RPL26L1	Pathway Commons Protein-Protein Interactions	1.0	null
GOLGA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38285
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC5226503__F4	PFOCR Pathway Figure Associations 2024	1.0	null
NABP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05339
PUS7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8546
MYOD1	ENCODE Transcription Factor Targets	1.0	null
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09335
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208741
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865873
A549_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158707
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973066
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3055
BRD-K83012560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16935
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159888
PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr10_69242881_T_C_b38	GTEx eQTL 2025	1.0	5.59691
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.02747
ACSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99309
NME1	Pathway Commons Protein-Protein Interactions	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.71701
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
Doxycycline (monohydrate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0195339
Insulin signaling pathway	KEGG Pathways 2026	1.0	null
Perturb_5890_KD_BCLAF1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.48155
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Betamethasone dipropionate_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0247333
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492146
Malotilate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248917
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CHUK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93533
Prostate adenocarcinoma_PRAD_TCGA-HC-7075-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.49857
BRD-K39761541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67573
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-527	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Paclitaxel_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0361082
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62066
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryoday8.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
Acetohexamide_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0225891
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
U251	GDSC Cell Line Gene Expression Profiles	1.0	1.48142
SMARCA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01711
AIMP1	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.80365
ASAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0888
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHEMBL:CHEMBL600862	DGIdb Drug Targets 2026	1.0	2.03585
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04833
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGFBR1_activemutant_291_GSE14523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.29251
HMBOX1_02_58	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.26167
JUN_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77886
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17365
GTEX-WFG8-2326-SM-3GILF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2347	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.78259
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.862003
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
RECQL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55327
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16729
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	1.10211
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016993
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24263752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30855
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.806
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPINDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79979
RDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56506
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASF1A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VC-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bile duct adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27602
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0515
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70447
USP10	Pathway Commons Protein-Protein Interactions	1.0	null
BI-78D3_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145473
Eye degenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Lipid storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
BRD-K95943192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34739
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01709
carbohydrate derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
SNGM_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.29068
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45041
oxaprozin-3794	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS34	DepMap CRISPR Gene Dependency	1.0	6.21838
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53894
PRDM14-21183938-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.599164
PMC6122955-elife-33947-supp2.xlsx-NY8_v_NY15_DE_Bru-seq-HNF1A-regulated_genes_Bru-seq_after_shRNA_in_NY8_or_NY15_cells_-_related_to_Figure_7A_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
LYZ	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3836_KO_ING3_SRP304782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.9255
BRD-A60487173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11613
ATP metabolic process	GO Biological Process Annotations 2025	1.0	null
CHEMBL:CHEMBL429095	DGIdb Drug Targets 2026	1.0	0.0814338
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.04708
BRD-K18887540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62994
LHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29919
postcentral gyrus, left, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855841
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03824
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02477
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71608
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07233
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35432
SLC25A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56868
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Keratoconus	DisGeNET Gene-Disease Associations	1.0	null
SNU1079	DepMap CRISPR Gene Dependency	1.0	12.1908
EHMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08542
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22564762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23838
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.421
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06924
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03329
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139636
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
rectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.991789
atp binding	GO Molecular Function Annotations 2015	1.0	null
PITPNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06417
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039495
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-1926-SM-3K2BA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57126
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021638
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32583
ABCF1	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism carbohydrate catabolic process	GO Biological Process Annotations 2015	1.0	null
PDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86605
BRD-K19652835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04254
Perturb_470_KO_MIR21_SRP256391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.8549
KU-19-19	GDSC Cell Line Gene Expression Profiles	-1.0	-1.82653
hsa-miR-3144-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
Offspring birth weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.930103
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_26_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79578
Norepinephrine (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0505736
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956586
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963236
GTEX-S4Q7-0326-SM-3K2B1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851505
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.96699
LB-100_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0300853
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.21345
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.111675
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180652
GALK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31622
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35907
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_16833_Mut_Runx3_SRP349093	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.0969
gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.712796
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21092
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12895
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.830042
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
REST-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266184
superficial stratum of FCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11848
Cinacalcet_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295145
ODAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86476
Neoplasms	CTD Gene-Disease Associations	1.0	1.10211
TENT4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42913
layer 3 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57193
JMJD1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01058
Perturb_5432_KD_IGFBP3_SRP377970	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.224
Perturb_5991_KD_ZNF438_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.58708
Lymphocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.75229
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24545
Trametinib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123119
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HT	CCLE Cell Line Gene CNV Profiles	1.0	2.21808
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36613
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ZBTB34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29259
Arbutin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027851
ZNF700	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12127
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
TM6SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09518
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860367
Perturb_7782_KD_ASCC3_SRP023199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.808
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
RDH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67712
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77888
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Pentose phosphate pathway	PANTHER Pathways	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Erdafitinib _COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.04138
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10636
hyperactivity	GWASdb SNP-Phenotype Associations	1.0	0.699367
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K27692586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6762
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17781
BRD-K47391428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93937
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5661
CWC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61678
BRD-K68083867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97705
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65734
CMK115	DepMap CRISPR Gene Dependency	1.0	2.36856
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37227
GTEX-XYKS-2226-SM-4E3IU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903488
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2773-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AZD-7648_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268131
CRCGN016_MCF10A.WT.HP_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31218
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-0826-SM-47JYC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851011
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144161
PMC8881251-18_2022_4183_MOESM2_ESM.xlsx-ERM_vs_P1-DEGs_ERM_versus_P1_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
SERPING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20142
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.17695
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203277
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Trimetrexate_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0247011
TLCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95651
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0526-SM-4DXTG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
BRD-K02802091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21277
BRD-K43449580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16586
ATIC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MMAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23527
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35685
A549_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013647
H1F0	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
PMC12165627-Supplementary_material-Suppl.5-s5.pdf-4-FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
SLVL	DepMap CRISPR Gene Dependency	1.0	2.01249
ICE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43479
KOPT-K1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3008
Intestinal mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3839
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Econazole_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0325637
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7006-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PC-3	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05844
BRD-K21610715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58288
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
PSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00797
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-337-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
maturity-onset diabetes of the young type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235844
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157549
Hematocrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.61549
GSE182179_2_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KTC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54703
single-organism catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K49529874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44223
UBAP2L	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K33986892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83195
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5680-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32142
hsa-miR-3130-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60304
TSR1	Pathway Commons Protein-Protein Interactions	1.0	null
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53438
FAM98A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-2426-SM-4B66I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22554
GSE131649_4_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Granulosa cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GTF2B	Pathway Commons Protein-Protein Interactions	1.0	null
Belumosudil_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0336982
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33279
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26653
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.217
Perturb_10691_KD_IGF2BP1_SRP291708	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.96311
Quetiapine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
MB21D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65918
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0277327
HOXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57247
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
DUS3L	Pathway Commons Protein-Protein Interactions	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25075
ELF1	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8533
TSC22D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81722
NSMCE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33054
Gemfibrozil_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0289137
Bimiralisib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0517
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.02814
BRD-K88662980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13213
GTEX-Q2AI-0526-SM-2I3EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65377
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7157
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K71521842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.88086
PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7027-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06538
GTEX-V955-2026-SM-3GAFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POP5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78789413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04248
glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.116537
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.056312
RHOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21277
C14orf28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37053
KYSE-70	GDSC Cell Line Gene Expression Profiles	-1.0	-2.09891
PKBalpha_KO_GDS1784_193_mouse_Embryonic fibroblasts (MEFs) - 0 hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999819
BRD-K40378743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18624
Amebiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
BV-173	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51049
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33387
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59776
Acute Myeloid Leukemia_LAML_TCGA-AB-2936-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49538
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00383
Photoreceptor inner segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.119
PARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10388
BRD-K13970506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23327
BRD-K51228600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2905
FEN1	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878128
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AZD1390_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0146969
H3K27me3_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EML4	Pathway Commons Protein-Protein Interactions	1.0	null
PECR	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2YK-0326-SM-4DM7D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07752
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131519
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.923666
Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P4HB	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7875-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K53356402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18578
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CY-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926045
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34767
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151198
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16749
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5307
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Piccolo NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.039
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74499
ADP	HMDB Metabolites of Enzymes	1.0	null
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.669
ML218	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
Rectum adenocarcinoma_READ_TCGA-EI-6512-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Radicicol	DeepCoverMOA Drug Mechanisms of Action	1.0	1.48
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13129
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89532
A549_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269699
SYNJ2BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35357
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4888-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34894
Esmolol (hydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282761
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39994
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T0-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
MBLAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25905
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73093
Lung squamous cell carcinoma_LUSC_TCGA-43-A474-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.824434
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73477
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.059
2,6-DIMETHOXYQUINONE	DGIdb Drug Targets 2026	1.0	0.58167
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01638
hsa-miR-320b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K45799338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32669
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Small_Intestine-enterocyte of epithelium of small intestine	Tabula Sapiens Gene-Cell Associations	1.0	8.5739
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
9-ING-41_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0304456
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_11090_OE_Alr_SRP153001	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S4-Table_S4_Top_500_differentially_modified_gene_bodies_between_AA_and_EA_patients_with_MM_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9887
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.980686
Diammonium Glycyrrhizinate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0307481
Prostate adenocarcinoma_PRAD_TCGA-VN-A88M-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LSM14B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ovary_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09213
HI-TOPK-032_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270686
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.846014
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27855
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198648
AZD2858_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0111201
organophosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36259
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2935
Glycolysis	PANTHER Pathways	1.0	null
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873031
CCDC152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61193
CHLORHEXIDINE GLUCONATE	DGIdb Drug Targets 2026	1.0	0.2143
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.861163
GSE162276_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25218
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00931116
EIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38894
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834227
CRCGN011_HEPG2_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0154
GABRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88644
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
BRD-K43936610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35398
ZNF174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40686
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13I-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12124
HNF1A-26855178-CACO2-HUMAN-COLON-ADENOCARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K09106444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09228
A 1120	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.4929
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZDHHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43499
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75639
IL21_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
SMARCC1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5023
glucose homeostasis	GO Biological Process Annotations 2025	1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12297505-41598_2025_11704_MOESM4_ESM.xlsx-table_s4_veen-TCGA-GBMLGG_AND_Human_kinases_NOT_GSE16011_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
IK	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K84935293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.93123
GSE210093_3_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fasting Blood Glucose Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carbidopa (monohydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0309788
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OVTOKO	DepMap CRISPR Gene Dependency	1.0	3.72871
UBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.90909
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27068
RAB3A_KO_GDS2483_701_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
intracellular glucose homeostasis	GO Biological Process Annotations 2025	1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.81593
Darinaparsin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0328121
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15409
Prostate adenocarcinoma_PRAD_TCGA-HC-7081-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76503
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47065
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55G-0626-SM-48FDB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94697940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4904
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.724939
Riluzole hydrochloride_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0279661
PMC6533083-elife-44306-supp4.xlsx-Table_S4-Supplementary_File_4_PAX8_gene_signature_expression_PAX8	Rummagene Transcription Factor Associations 2026	1.0	null
Peretinoin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0412741
Lysosomal storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.66755
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.29719
Perturb_5935_KD_MYBBP1A_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.9879
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82601
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_UP-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_up_to_an_FPKM_of_at_least_2_LEUTX	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A814-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111852
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.839153
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.337356
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_11493_OE_Tnfsf15_SRP106312	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65018
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.07797
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.433
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.996272
tcof1_15522210_neuroblastoma_gof_mouse_gpl339_gds998	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.468954
786O	DepMap CRISPR Gene Dependency	1.0	2.04553
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K22471908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75325
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050294
Fluvoxamine (maleate)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0159826
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TOV21G	CCLE Cell Line Gene CNV Profiles	1.0	1.35864
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.903272
9-ING-41_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.044712
NCI-H28	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K89652482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95709
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69922285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13428
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRSF4	Pathway Commons Protein-Protein Interactions	1.0	null
FASTKD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60978
DKMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67269
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.95844
hepg2	HPA Cell Line Gene Expression Profiles	1.0	1.0725
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95460104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02022
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050964
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3098
BRD-A75087829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11029
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22319
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
D-Fructose	HMDB Metabolites of Enzymes	1.0	null
ESF1	Pathway Commons Protein-Protein Interactions	1.0	null
Ralimetinib dimesylate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.032444
FEM1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21318
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11582
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PAX3_01_359	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.63311
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848369
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J2-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96834095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85432
GTEX-XPVG-0526-SM-4B65N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.33638
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34981
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40026
BRD-K07602825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13056
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
hsa-miR-1243	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873762
BRD-K52436508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24549
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oc316	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9407
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SRSF7	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-99-8033-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE209928_0_v_1_kmt2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHRNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8056
inner SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.890845
glucose	GeneRIF Biological Term Annotations	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31667
Perturb_4635_KD_Rbbp7_SRP344781	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.59903
hsa-miR-3123	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
C4orf48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63872
ethotoin-3892	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.19319
REL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52916
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050427
small intestine	HPA Tissue Gene Expression Profiles	1.0	1.17199
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167583
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12579
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46969
Fetal_Intestine_Small	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.23598
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYNE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83122
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175626
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15426
TCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78903
BI-3406_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0299189
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K09521953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07242
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3271
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MEC1	DepMap CRISPR Gene Dependency	1.0	2.26027
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07728
PEBP1_KO_GSE31150_52_mouse_pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010562
BAY1125976_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0534222
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MELAS - Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes_Muscle - Striated (Skeletal) (MMHCC)_GSE1462	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.81211
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209533_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer 5 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23903
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375967
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.4
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43774
PMC8534692__F7	PFOCR Pathway Figure Associations 2024	1.0	null
breast	HPA Tissue Protein Expression Profiles	-1.0	-1.12519
Alanine aminotransferase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.60969
LCMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99876
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TOR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81921
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056219
APOA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23238
glycolytic process	GO Biological Process Annotations 2025	1.0	null
SLC35C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08874
A549_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268587
COL9A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44012
GSE249544,GSE249637_8_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31624501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77761
bace2	GeneRIF Biological Term Annotations	1.0	null
SK-OV-3	GDSC Cell Line Gene Expression Profiles	1.0	2.32653
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.833675
Filgotinib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264973
Encorafenib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258118
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22685
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-SNOS-1026-SM-4DM4Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_13790_KO_Zeb2_SRP066910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421252
SIK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62236
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29314
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36868
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3_Ectopic expression_GDS4080_622_human_Basal Breast Cancer Cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.029779
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870836
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39032
GTEX-UPJH-0626-SM-4IHJN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03505
MIDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76037
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8125
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.34664
BRD-K16403365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39022
UDP-N-acetyl-D-galactosamine biosynthesis II	HumanCyc Pathways	1.0	null
PMC9992472-41467_2023_36735_MOESM5_ESM.xlsx-SOX11_OE_9h_in_SH-EP-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
BRD-A19829191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9089
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K98586629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11925
AZD2858_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0422736
piribedil-6333	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Rimonabant_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0344869
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7666
HOP62	CCLE Cell Line Gene CNV Profiles	1.0	1.32888
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.7569
EX229_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.048973
18504433-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77G-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.889259
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.79841
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM25	Pathway Commons Protein-Protein Interactions	1.0	null
decreased liver triglyceride level	MGI Mouse Phenotype Associations 2023	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56279
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
YKG1	DepMap CRISPR Gene Dependency	1.0	2.20908
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4983-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97445906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41506
Paclitaxel_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0297202
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
cpeptide	GeneRIF Biological Term Annotations	1.0	null
A549_MC1568_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145379
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40099
POLRMT	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-REY6-0426-SM-2TF5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE242199_9_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215472
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947425
GTF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90221
sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10506
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Ray cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63945
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214613
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3074-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K77884956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07885
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02801
GTEX-PLZ6-0426-SM-2I5FG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902842
Brain Lower Grade Glioma_LGG_TCGA-R8-A6ML-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21692
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018052
ENAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56763
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26041
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862062
H1_Derived_Neuronal_Progenitor_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.930907
PMC11544636-CCS3-18-e12047-s001.xlsx-Supplementary_Table_S2-Supplementary_Table_S2_554_differentially_expressed_genes_between_DOX_and_CTR_D0_in_A673pTERshEWS_FLI1_model_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Dopaminergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34438
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21831
Adenosine triphosphate	HMDB Metabolites of Enzymes	1.0	null
GTEX-WVLH-0626-SM-3MJG7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05233
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ERI1	Pathway Commons Protein-Protein Interactions	1.0	null
Darinaparsin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0301985
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41674
Almonertinib (mesylate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0293778
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
CLDN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26915
second (ventral) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58751
GSE168797_4_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
LRP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44991
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.83022
TCS 1102	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21515
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KCNK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02281
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16624
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967075
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UFSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6208
NARS	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66263
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DDX3Y	Pathway Commons Protein-Protein Interactions	1.0	null
CCDC124	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.864
BRD-K42016545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00299
VMRCRCW	CCLE Cell Line Gene Expression Profiles	1.0	1.44564
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.109446
kidney	GTEx Tissue Gene Expression Profiles	1.0	1.05492
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6089
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97479
Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GU-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
maturity-onset diabetes of the young	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K58044926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31667
SNU398	DepMap CRISPR Gene Dependency	1.0	2.36248
JNK_KO_GDS3001_531_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-RU1J-0226-SM-2TF5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861268
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10648
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00862
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9746
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
Lopinavir_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0211649
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48483
carbohydrate phosphorylation	GO Biological Process Annotations 2023	1.0	null
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Rucaparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190489
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
Retinitis Pigmentosa	DisGeNET Gene-Disease Associations	1.0	null
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07883
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188669
GTEX-XUJ4-0726-SM-4BOOP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04964
GIPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29381
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39596
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216493
GTEX-SNOS-1626-SM-3NMA4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933352
Secondary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
CB-88-LG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203726
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86888
PRPF31	Pathway Commons Protein-Protein Interactions	1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.4568
TMED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27661
DDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00068
GTEX-U3ZM-0926-SM-4DXSW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PMC9426234__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Hexokinase, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927549
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
Glucose 6-phosphate	HMDB Metabolites of Enzymes	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
TAF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
GSE86507,GSE86509_7_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206611
HSDL2	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012524
WRNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02755
hsa-miR-518a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.65113
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_14524_KO_LRHt_SRP009598	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Mitochondrial pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
RBM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54489
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4753-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
SLC25A39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15243
CAPRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177447
TMEM240	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53743
A549_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219527
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
8-Hydroxyquinoline_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141403
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168797_2_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Elimusertib hydrochloride_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206146
F8A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52433
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
EIF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59208
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18926
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55C-0526-SM-3GIKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982251
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961699
SUPT5H	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10251551-12885_2023_11010_MOESM4_ESM.pdf-0-ENSG00000125398_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.23435
H290	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NELFB	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
USP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59588
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00718
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.945402
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35035
Tubulin inhibitor 6_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0324858
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.97684
Perturb_3774_KD_CDK10_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29984
Neomycin, kanamycin and gentamicin biosynthesis	KEGG Pathways 2026	1.0	null
RASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65596
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.36361
cisplatin_homo sapiens_gpl6480_gse33482	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61112
GATA1-19941827-MEL-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0446
LS1034	CCLE Cell Line Gene Expression Profiles	1.0	1.73098
GTF2E2	Pathway Commons Protein-Protein Interactions	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8371
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.94935
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K37657049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25037
AZD2858_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0112763
Perturb_8986_KD_OPA1_SRP216831	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78467
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.60032
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.63084
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QV31-1626-SM-2S1QC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MFGE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50723
EMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53761
ML264_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0464774
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33901
Retrosplenial area, lateral agranular part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45867
ANKS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9295
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP2K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33042
RCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60592
Small_Intestine	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.26707
A549_ZM 447439_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191913
GTF2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04013
Bicalutamide_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0128845
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF264	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08064
Perturb_9555_KO_Atg16l1_SRP159288	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.6222
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SRSF5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4237
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20127
glucokinase activity	GO Molecular Function Annotations 2025	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.06143
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2905
Perturb_6474_KD_YAP1_SRP111293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.20493
C2orf49	Pathway Commons Protein-Protein Interactions	1.0	null
SYNCRIP_02_10	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.5025
PLOD1	Pathway Commons Protein-Protein Interactions	1.0	null
Chloro-L-alanine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
BRD-K67597437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42563
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.96412
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7471-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0193
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3029
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.02846
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09679
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SF-2126-SM-3K2B2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881836
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
RCC-FG2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52231520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40689
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995478
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40106
RECQL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0363
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
EIF5B	Pathway Commons Protein-Protein Interactions	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828825
IKBKB_Constitutional activation_GDS4119_621_mouse_Prostate epithelium	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.920525
UBXN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06424
TFB2M	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.897681
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
CWF19L1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12165
Hexokinase, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	2.5925
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169606
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828825
EXOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47601
OXOPURPUREINE	DGIdb Drug Targets 2026	1.0	0.58167
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00338
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901207
ATF2	ENCODE Transcription Factor Targets	1.0	null
MRPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73969
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.34937
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PDF	Pathway Commons Protein-Protein Interactions	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.982567
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8398-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_288_KD_JMJD6_SRP334376	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.40673
APTO-253_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0279274
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Retina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.267
TCF21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81716
KHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22058
hsa-miR-3167	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
DNAJC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97685
Perindopril	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
Neratinib (maleate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0368105
Alpha-D-Glucose	HMDB Metabolites of Enzymes	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.80607
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-FOXP3_mod_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal retina photoreceptor layer morphology	MGI Mouse Phenotype Associations 2023	1.0	null
WT1_01_08	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.84899
MG-132	DeepCoverMOA Drug Mechanisms of Action	1.0	4.34
GTEX-PLZ6-0626-SM-3P61B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859132
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7CZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26443
NCIH1373	CCLE Cell Line Gene CNV Profiles	1.0	1.93147
IGROV-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827823
seizures	GWASdb SNP-Phenotype Associations	1.0	0.710116
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26259
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CCK81	DepMap CRISPR Gene Dependency	1.0	3.64144
PPRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65122
Vemurafenib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224286
Aprepitant_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0402873
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-0426-SM-3GIL4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843158
Mean corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.11549
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34989
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28856
lower dorsal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62543
GSE160077,GSE160084_2_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSG-0426-SM-3GIKD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915216
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68257
USP7	Pathway Commons Protein-Protein Interactions	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37582
mannokinase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23487
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01753
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrosplenial area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3137
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TMN 355	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
CRCGN017_MCF10A.TP53.M_24H:I09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18645
hexose metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Retinitis pigmentosa 73	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49827
MAP1LC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44186
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45842
Larotrectinib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0305032
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35176
BRD-K44304623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19175
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29189
Digitoxin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0286397
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930329
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825997
BRD-K92849826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34472
Retrosplenial area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07858
Clotrimazole_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244174
PMC11746978-41598_2025_86316_MOESM2_ESM.xlsx-sheet2-Only_MR_or_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.63042
GSE102342,GSE102648_1_v_0_curcumin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209202
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871417
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157099
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
DT-061_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0324927
DDX54	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFON-0626-SM-4LVLX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29857
LMAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8547
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GAR1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76555
BRD-K56520530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00814
PRKAG3_Mutation (R225Q)_GSE4067_390_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Everolimus_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264145
EHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90618
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17008
CEP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78549
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13487
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.932966
ZNF91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65212
postcentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.973875
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
LIVF001-029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07011
BRD-K57084585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4364
A549_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015886
TEX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.41595
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89304
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9756
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MOLP8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78761
EIF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80291
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184845
BRD-K63654001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79135
PMC9734180-41398_2022_2274_MOESM8_ESM.xlsx-Supplemental_Table_2-Supplemental_Table_2_Genes_regulated_by_TFEB_expression_are_altered_in_MAPT_p_R406W_brains_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06832
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04055
Sapanisertib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0253791
NCIH2030_LUNG	CCLE Cell Line Proteomics	1.0	2.77993
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.49012
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26838
HEC50B	CCLE Cell Line Gene Expression Profiles	1.0	1.55998
GTEX-XPT6-2126-SM-4B66P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910063
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149539
GTEX-QDVJ-0926-SM-2I5FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23231
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49294
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.0766
Decitabine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0328229
NPEPPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85424
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
HL-7702 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.54
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922187
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60997
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6ZZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37273
TRIM71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16946
NANS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84451
BRD-K16355056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16404
BRD-K80602847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3122
NPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53963
GTEX-XGQ4-1226-SM-4AT67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33986
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37702
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU685_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.05186
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31625
RBM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50207
WBSCR22	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Harringtonine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0295953
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cysteamine (hydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265293
ASPH	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85418917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63497
GTEX-PLZ6-1726-SM-2S1O6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11075
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2429
TSPAN17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60282
Birth weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.7699
(R)-Verapamil (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0352814
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
EWSR1_KD_GDS4962_467_human_not specified	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Artemether_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0377145
BRD-K91795767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27932
NOC4L	Pathway Commons Protein-Protein Interactions	1.0	null
Pemigatinib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0236781
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
WFS1_KO_GDS4526_111_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H1-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71636
CHCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2916-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233644
GTEX-S4UY-0826-SM-4AD4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38393
BRD-K95678449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3622
Isocortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00157
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050996
SRSF9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
NOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42354
BRD-K82508779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49224
BRD-K59831227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62124
RAB11FIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31776
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2527
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
LRRC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38214
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.907139
PMC11544636-CCS3-18-e12047-s001.xlsx-Supplementary_Table_S7-Supplementary_Table_S7_Four_cluster_profiles_using_short_time-series_expression_miner_STEM_algorithm_in_A673pTERshEWS_FLI1_model_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5839
REST	ChEA Transcription Factor Targets	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prediabetes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.491
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
FOS	ENCODE Transcription Factor Targets	1.0	null
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149207
GTEX-WFG8-2526-SM-3GILR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847755
TRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22333
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-487-GLI1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Vandetanib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141111
PKNOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01818
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PMC9437810-mmc6.xlsx-Sheet1-Table_S8_Significant_isoform_switches_unique_to_BE_LGD_TP53_WT_vs_BE_HGD_TP53_MUT_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Neratinib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0329419
IFT46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96252
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019916
BRD-K14241686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15947
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_5973_KD_TCF25_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.41289
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
mRNA_RXRA_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193839
Primary visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57978
BRD-A61864215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12544
intracellular glucose homeostasis	GO Biological Process Annotations 2023	1.0	null
Rutin (trihydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262888
cellular carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
TRA2B	Pathway Commons Protein-Protein Interactions	1.0	null
ARID4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81512
GTEX-WL46-0526-SM-3LK7W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SERINC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01383
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44024
KML1	DepMap CRISPR Gene Dependency	1.0	2.74331
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
MERCK544	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
ZNF250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75837
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.626
BRD-K15427120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0102
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269357
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RM2N-0526-SM-2TF4N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831371
GTEX-WFG7-1726-SM-4LVME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94479
epilepsy syndrome	GWASdb SNP-Disease Associations	1.0	0.814185
Trifluridine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0304478
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
SAOS-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
etynodiol-6678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4317_KO_Fmn2_SRP109283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.47482
GP5d	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.02942
LCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67369
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0198
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28057
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0426-SM-2TC65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965154
Brain Lower Grade Glioma_LGG_TCGA-QH-A86X-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1033	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
SF767	CCLE Cell Line Gene CNV Profiles	1.0	2.34417
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
SRP9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K25196723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12981
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K12959846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11556
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
NPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48386
SSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65482
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
AARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08429
PRDM14	ChEA Transcription Factor Targets	1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5285
EPB41L2	Pathway Commons Protein-Protein Interactions	1.0	null
neuroblastoma	GAD Gene-Disease Associations	1.0	null
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93721
RAB5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18609
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25741
preoptic telencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16923
ZNF184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21935
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829005
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3029394-pone.0016617.s001.xls-Down-regulated-Table_S1_Genes_down-regulated_by_SOX2_over-expression_0_5-fold_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3057
SEC14L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69977
HSOS1	DepMap CRISPR Gene Dependency	1.0	4.1451
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
TIMM50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50593
hippocampus (hippocampal formation)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.43172
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
abnormality of movement	GWASdb SNP-Phenotype Associations	1.0	0.30704
BRD-K36104357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12953
IRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51212
hsa-miR-500a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
LRRC8E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01453
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7697
SHQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62367
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11288
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LUC7L	Pathway Commons Protein-Protein Interactions	1.0	null
RAB24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57163
BRD-K50058129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85868
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93176
BRD-K16518464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31695
BARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72461
GTEX-PX3G-2426-SM-48TZZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
TP53_01_10	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60887
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.872936
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
EEF1E1	Pathway Commons Protein-Protein Interactions	1.0	null
BLUE1	DepMap CRISPR Gene Dependency	1.0	2.97907
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4048
HMGB2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ileocecum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7549
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7233
HT29_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.47497
Learning Disorders	CTD Gene-Disease Associations	1.0	1.95919
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200071
GSE249544,GSE249637_9_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NXF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GRHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63941
BRD-K23075656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69254
RPS27L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84338
GTEX-WFG8-0926-SM-3GIKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1488
GTEX-S33H-1126-SM-2XCB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
FAM50A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84378
BRD-K89436979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85291
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220851
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.7881
BRD-K77480803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59022
Hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MAPKAPK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26128
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0753
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACHN	GDSC Cell Line Gene Expression Profiles	1.0	2.18656
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K19227646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02524
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27845
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GMCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81351
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5109
rectal cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55E-1126-SM-48FDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21054
COX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57156
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36499
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62313
BRD-K00010082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50487
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44948
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.916406
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPR162	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26156
Brain Lower Grade Glioma_LGG_TCGA-DU-8164-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05127596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12315
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
Vital Capacity	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K97700172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43292
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38647
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29895
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5324-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM129	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82161
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20884
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50907
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.53367
GSE181521_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34345
Belumosudil_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186047
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09156
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SLC27A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2516
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-5595-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05043
GUF1	Pathway Commons Protein-Protein Interactions	1.0	null
Rimonabant_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0323548
GSE238018_1_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CORT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08633
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.45443
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48517
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
KCTD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27519
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019767
TAL1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K82521348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19862
ARMC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18335
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.55524
Pemigatinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266929
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75639
phosphorylation	GO Biological Process Annotations 2015	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.39394
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135575
PPWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29381
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.894783
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.34891
Goserelin (acetate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222409
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18577
RPS17	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193249_0_v_1_gpx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Econazole_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0100002
Glycolysis / Gluconeogenesis	KEGG Pathways 2026	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZCCHC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15294
GTEX-VJYA-0326-SM-3GAEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34483
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13841
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215074
GTEX-WYBS-0326-SM-3NM8S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08469
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX55	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K72934808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38335
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413666
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_DMOG-Unnamed_5_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Late-Onset Retinal Degeneration (Disorder)	DisGeNET Gene-Disease Associations	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.97084
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
layer 4 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45099
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40997
TXNDC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42981
fructokinase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K73166462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05527
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.940024
Retrosplenial area, ventral part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14136
phosphorylation	GO Biological Process Annotations 2023	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3504
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833732
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19724
intermediate-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903522
A498	CCLE Cell Line Gene Expression Profiles	1.0	1.3721
SARS-BatSRBD_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.57092
Lung adenocarcinoma_LUAD_TCGA-62-A471-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
17683608-TableS4	GeneSigDB Published Gene Signatures	1.0	null
YPEL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89388
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29173
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918396
SOX2	ChEA Transcription Factor Targets	1.0	null
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8153
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R3RS-0626-SM-48FE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05408
OVCAR-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZKSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84941
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
sporozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.663962
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5356-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sublayer 6a of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34825
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7647-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Demeclocycline_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0252321
BRD-K03715233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32965
A549_Barasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135566
JA-63-WB39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204253
HCC2157	CCLE Cell Line Gene CNV Profiles	1.0	2.66555
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
20460542-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
DIS3	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.95864
biological regulation	GO Biological Process Annotations 2015	1.0	null
smallintestine_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.04802
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.976659
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863607
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.857337
HEC108	CCLE Cell Line Gene Expression Profiles	1.0	1.79667
PPAR-26484153-CHIP-SEQ-NCI-H1993-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTF2E1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7429-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33956641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67809
KGN	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.65325
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0684
ANKS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32524
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Newfoundland cone-rod dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871904
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73797
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25322
alpha-TC1.6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
BRD-K31210612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84423
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36674
PGBD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36879
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9781
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_8071_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873762
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24598
H3F3A	Pathway Commons Protein-Protein Interactions	1.0	null
Hepa-RG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
BRD-K59324446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06911
OSC20	DepMap CRISPR Gene Dependency	1.0	2.15311
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tucidinostat_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166815
FKBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08249
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41047
EZH2	ChEA Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00782
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44617
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4748	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
496100490_HIP_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02989
MICAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76119
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lonafarnib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185054
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07121
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE163862_1_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE211866_2_v_1_usp11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEC265_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	4.02364
GSK3B_knockdown_202_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.40784
CRCGN016_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48232
Somatomotor areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28117
chr10_69127206_A_G_b38	GTEx eQTL 2025	1.0	2.15622
POLR3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glucose homeostasis	GO Biological Process Annotations 2023	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869161
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3559
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07931
ATXN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86719
USF2	ENCODE Transcription Factor Targets	1.0	null
Lapatinib ditosylate_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0351117
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.06368
BRD-K88802328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4052
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40252
BRD-K99736408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09612
RINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00275
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192316
Sarcoma_SARC_TCGA-QQ-A8VG-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU761	DepMap CRISPR Gene Dependency	1.0	2.64835
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02986
BRD-K06994380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35924
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.73393
TMEM132B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79562
parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.296211
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.955782
CROCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96578
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43982279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24795
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65473
PMC12248208-bmjgast-12-1-s001.pdf-8-PPARG_PPARG	Rummagene Transcription Factor Associations 2026	1.0	null
CLCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72177
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31702
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MLL1/2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.556
786-0	GDSC Cell Line Gene Expression Profiles	1.0	2.68271
Diseases in Twins	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OIZH-2626-SM-2HMJM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37884
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81607
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QCQG-2026-SM-2S1PH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13298
SUDS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31329
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
A549_SRT3025 HCl_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128619
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20415826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49518
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25098
peritoneal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.466885
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K67087027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.79396
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
MOLT-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Malotilate_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0301876
ZNF226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35431
Paclitaxel_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0660604
GSE169205_3_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ixazomib citrate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204596
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00577
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Salicylic acid_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191536
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RWS6-0226-SM-2XCA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825788
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.175209
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
MBOAT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72352
LUZP1-20508642-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POP4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6200_KO_Firre_SRP076940	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.57354
GTEX-P4QT-2626-SM-2I3FM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885743
QARS	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3494
TCF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74304
ZC3H4	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6847
a549	HPA Cell Line Gene Expression Profiles	1.0	1.12184
Alpelisib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0358595
HIST1H1E	Pathway Commons Protein-Protein Interactions	1.0	null
glucose metabolic process	GO Biological Process Annotations 2025	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A907-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chr10_69215604_G_C_b38	GTEx eQTL 2025	1.0	2.00725
BRD-K83481256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06764
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73906
subcutis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.618603
SAOS2_BONE	CCLE Cell Line Proteomics	1.0	2.71215
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156074
Brain Lower Grade Glioma_LGG_TCGA-R8-A6MO-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCIH358_LUNG	CCLE Cell Line Proteomics	1.0	2.67935
BRD-K54036439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91474
EXOSC6	Pathway Commons Protein-Protein Interactions	1.0	null
Flumatinib (mesylate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219388
GTEX-U8XE-1226-SM-4E3HN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.775
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858692
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883233
Perturb_2055_KD_NR2F2_ERP124128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEN	CCLE Cell Line Gene Expression Profiles	1.0	1.4874
BRD-K50950731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64087
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03466
Elimusertib hydrochloride_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02939
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MOGS	Pathway Commons Protein-Protein Interactions	1.0	null
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233784
TCCSUP_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.71215
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ8I-2126-SM-4BOOM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1825
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K30145193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72956
FOXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16462
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18675
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05934
RNF38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90731
PECAPJ34CLONEC12	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83982
GPR37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40885
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43064
PUF60	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85580909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04648
BRD-K50140257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58131
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11236
mRNA_PRDM14_20953172	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTPN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98953
CDX2-20551321-CACO-2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SF3B5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SBI-0640756_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.032544
Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Temuterkib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0198708
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.883239
OV-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WYJK-1126-SM-3NM9Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.22206
IRGQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5634
Rectal cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RU72-1126-SM-2TF6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03161
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140964
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
H2BC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2021
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17236
emx2_20962046_e10dot5_urogenital_epithelium_lof_mouse_gpl1261_gds3173	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.711891
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_14659_KO_Insm1_ERP127840	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
DYRK1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48869
terminal nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06688
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K45941986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96478
Central carbon metabolism in cancer	KEGG Pathways 2026	1.0	null
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Beta-D-Glucose	HMDB Metabolites of Enzymes	1.0	null
RMND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18766
PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
Citalopram (hydrobromide)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196715
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GSE216538_1_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53612668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30565
NCI-H1688	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_ZFAND3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97369
A549_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218133
BRD-K09232527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07602
FLAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56376
Valdecoxib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120369
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0349
A549_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180026
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	1.32776
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
DDX18	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.81113
ZC3HAV1	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926129
Minodronic acid_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.035409
BRD-K38493972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59269
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.045
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
Pemigatinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.061263
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hoxa11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1663
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
S-Adenosyl-L-methionine (disulfate tosylate)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175751
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Meloxicam_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0331686
eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.102708
SLC1A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9803
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128509
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32937
POLR3C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Clonidine (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250204
TAK-901_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0319331
vincristine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0533325
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
carbohydrate catabolic process	GO Biological Process Annotations 2025	1.0	null
GSE220520_5_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195756
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
retina outer nuclear layer degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TM9SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34906
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Darolutamide_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0344661
glucose 6-phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT2_KD_vs_SCR-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9605
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.867853
BRD-K18211442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00752
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865741
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.832683
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.18301
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C1-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82002014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07081
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840082
EGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87676
BRD-K92446632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20665
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0174
PMC5226503__F4	PFOCR Pathway Figure Associations 2023	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
A549_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118592
CDK11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19507
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.917571
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70082
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.26242
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294374
NME2	Pathway Commons Protein-Protein Interactions	1.0	null
Anastrozole_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251049
c-Kit-IN-1_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0239129
NVP-BHG712_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0479452
BRD-K75821161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18358
Omeprazole_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245197
496100491_HIP_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96452
Epoxomicin	DeepCoverMOA Drug Mechanisms of Action	1.0	5.05
Perturb_15744_KO_Cyp4v3_SRP358013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.00623
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170822
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
small intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Rapamycin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180085
Pralsetinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0499475
TCL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35353
CPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14746
POLR3A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100480_HIP_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01666
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18801
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
Renal proximal tubule epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
BRD-K86036680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06111
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Regorafenib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0338411
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96181
FXR1	Pathway Commons Protein-Protein Interactions	1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7253-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.842396
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42419
GTEX-OOBJ-2626-SM-2I3F6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15386
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UQCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77618
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XAJ8-1126-SM-47JYA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929164
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9494
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30065842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22184
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6927
hsa-miR-320a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OSBPL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24545
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130375
BRD-K44371786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00268
RDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35328
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
Tassel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DLX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98905
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.74321
estradiol-5960	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
UACC257	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.3124
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.912989
BRD-K56738235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4537
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48802
Pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
MYO19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40012
BRD-K46609723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24427
LMX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51737
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7714-01A-12R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97276563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10149
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9601_KO_Satb2_SRP307576	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Lipoic acid_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0108892
Perturb_7152_Mut_RNF43_SRP237436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.81571
AE-13-CX28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.769903
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17194
NCIH2122	CCLE Cell Line Gene Expression Profiles	1.0	2.21494
H2BC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95119
Perturb_7048_KO_Dll4_SRP057171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.75556
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.587
PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT1_AKT2_KD_vs_SCR-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WY7C-2626-SM-3NB2P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33382
SCNN1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35832
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Subfornical organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.26236
BRD-K66838288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77052
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09756
CERS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49463
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K56658444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73833
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.96412
BRD-K32118188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66229
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050502
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25173
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
NUGC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00826049
OARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59453
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269068
SAMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48154
C16orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01454
GTEX-S7SF-0426-SM-3K2B7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26084
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Radotinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271979
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01256
GSE185163_3_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.45617
RPP38	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72505
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43177
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23374
PMC9314667-Table_1.xlsx-Regulons-ATF4_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6145927-41467_2018_5729_MOESM6_ESM.xlsx-TF_Activity_Genesets-Chu_GATA3__UP_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11648256-mmc3.xlsx-Tab_S2_AA_Mod_27_SNP_BMI_INT-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81G-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15411_KD_GATA2_SRP043960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.33564
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39805
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8451_KD_EphA2_SRP237314	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Everolimus_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0938679
A549_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023344
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
JPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02358
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
trophozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.757845
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05537
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ_02_199	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.66051
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.3777
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43390655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33531
Nafamostat (mesylate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0301547
GTEX-RN64-1626-SM-48FD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55846
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-OXRK-1426-SM-3NB19	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.08904
CPLANE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29269
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
A549_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171306
BRD-K66973998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90464
GSE211357_2_v_0_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
6-phosphofructokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.138
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86291
GMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88218
CPSF2	Pathway Commons Protein-Protein Interactions	1.0	null
MTDH_DEPLETION_GDS3179_98_human_LM2 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.44129
HIST1H1B	Pathway Commons Protein-Protein Interactions	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
AE-05-CB45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201357
BRD-K33221810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10205
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856561
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fructose and mannose metabolism	KEGG Pathways 2026	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74185
CLDND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9804
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44735
TPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21026
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.012754
Procainamide (hydrochloride)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02349
Starch and sucrose metabolism	KEGG Pathways 2026	1.0	null
GTEX-X4EO-0126-SM-3P5YN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17947
CHEMBL:CHEMBL2095095	DGIdb Drug Targets 2026	1.0	0.226205
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888055
COBLL1	Pathway Commons Protein-Protein Interactions	1.0	null
PTPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64978
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3189
cellular homeostasis	GO Biological Process Annotations 2015	1.0	null
Hesperidin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203179
EIF4E	Pathway Commons Protein-Protein Interactions	1.0	null
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7281
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-27-XF09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320943
MAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34179
BRD-A02501536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91622
AKT2_knockdown_44_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.59323
GSE164884_2_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185012
(R)-Verapamil (hydrochloride)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0328635
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Panobinostat_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0229152
Lumateperone (tosylate)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209528
BRD-K25773863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19284
oxaliplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60955
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169493
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.807
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6955
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.676
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161811
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0826-SM-4AD5E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861593
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19634
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4455
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U5-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K61274359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55084
RAB5IF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09202
oval paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11027
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05246
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_12Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.79169
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05058
Lung adenocarcinoma_LUAD_TCGA-97-A4M6-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MGST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5133
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPC	Pathway Commons Protein-Protein Interactions	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE86507,GSE86509_4_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEXIM2	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
inner SZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910778
LOXIMVI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE210476_2_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48927
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Geep	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.321
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79837
Perturb_15819_KO_PINK1_SRP343083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.70713
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
KLRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9212
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191110_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
VAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07787
intermediate stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29855
Norepinephrine (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0213957
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Amino sugar and nucleotide sugar metabolism	KEGG Pathways 2026	1.0	null
BRD-K83254798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18906
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.782
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.662218
WFS1_KO_GSE33372_395_mouse_hypothalamus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RAB11FIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97782
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Metabolic dysfunction-associated steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29209
PRPF4B	Pathway Commons Protein-Protein Interactions	1.0	null
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K89891928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09352
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.80983
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2527
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926129
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Tafluprost	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49573242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31623
A498	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.18126
PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	5.06466
CYB561D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99363
Finasteride_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0325001
ZFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91446
adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.175279
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
SOX4_01_260	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.06245
BRD-K03116744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7585
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DALRD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76292
SNU840	CCLE Cell Line Gene CNV Profiles	1.0	1.63388
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0466
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37826
thp1	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
PDCD6IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36578
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6296
Brain Lower Grade Glioma_LGG_TCGA-HT-7677-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78071
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959431
Gefitinib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0218416
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25676
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.972157
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
A549_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143305
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MITF_01_79	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.09671
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.996708
Perturb_1355_KO_circSCL38A1_SRP342299	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.59795
Bile duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
BCAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62999
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.61577
Sodium Salicylate_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0170073
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19362
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SN-56 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
XRN2	Pathway Commons Protein-Protein Interactions	1.0	null
GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52492854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53454
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57193
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.267
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24598
BRD-K25280080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3158
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19889
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15373
BRD-K15947051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06993
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00543
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14376
MANBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98959
PURA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28021
KYSE-50	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182812
Erdafitinib _CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216302
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21784
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Hexokinase, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0704
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53639
KDM5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88617
GTEX-W5WG-1426-SM-4KKZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960831
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.11233
PHF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20959
NACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56753
BRD-K77554584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05946
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
FOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13935
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAK-733_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.073443
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
N4BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29388
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46533
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
EIF3F	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04680784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27539
cefalexin-5250	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051153
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARID1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92579
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.29383
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333417
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GSE176305_0_v_1_rotenone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60492
PU.1-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39049
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63591
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9746
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71797
GSE193993_0_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76308
PBXIP1	Pathway Commons Protein-Protein Interactions	1.0	null
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
Primary visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15828
r2 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04019
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210554
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905296
ALEXIDINE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.239511
PGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13476
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24471
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64483847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22088
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157433
MRPL44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40045
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153249
mantle zone of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2855
BRD-K56939159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51278
COL1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97412
NARS2	Pathway Commons Protein-Protein Interactions	1.0	null
Silodosin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224326
Sodium Salicylate_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145981
Sinomenine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242921
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76917
IGSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9006
BRD-A89983325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34684
Perturb_9584_KO_Vdr_SRP115411	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.00552
alpha-yohimbine-5800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U8XE-1426-SM-3DB8Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91555
Abemaciclib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0312347
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.3163
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-66-OE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.564394
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73093
GJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34505
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Demeclocycline_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0199803
PMC8031408-pone.0249773.s002.xlsx-ST12-S12_Table_Genes_with_selection_signals_located_at_GeneHancer_elements_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.04586
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5905-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPACA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04052
EXOSC4	Pathway Commons Protein-Protein Interactions	1.0	null
SKMEL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48227
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
subcutaneous adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.647721
JMSU1	CCLE Cell Line Gene CNV Profiles	1.0	1.42044
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
RBM12	Pathway Commons Protein-Protein Interactions	1.0	null
OVOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42741
18787218-tableS1	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UB-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Divalproex Sodium_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118045
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77809
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46379
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32549
GSE205332_1_v_0_queuine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP5ME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77994
DBR1	Pathway Commons Protein-Protein Interactions	1.0	null
DYNC2I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55305
MYB-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Tucidinostat_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244083
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12233_KD_STAT3_SRP081918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.6459
ACO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00725
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4Z8-0426-SM-3K2AH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22502
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDIT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75242
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	1.0	1.68029
GTEX-QEL4-0426-SM-3GACZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959013
Acetazolamide_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0456004
PJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24272
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57531
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02765
BRD-K80424876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45309
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.14954
HUH6	DepMap CRISPR Gene Dependency	1.0	2.16426
CTV1DM	DepMap CRISPR Gene Dependency	1.0	3.60505
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217729
GSE168807_6_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23704908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22202
BRD-K71420819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45286
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.352227
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC5509726__F3	PFOCR Pathway Figure Associations 2024	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.04622
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12329
DISP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52616
GTEX-RUSQ-0626-SM-2TF5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.394
639-V	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.94761
Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-D1-D3_643_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22433
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.05828
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
C19orf53	Pathway Commons Protein-Protein Interactions	1.0	null
JADE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.95961
CRCGN015_HEPG2_48H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69445
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8253
BRD-A57174914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47016
PCDHGC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49595
Fusidic acid_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0369262
BRD-K45348630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57213
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PJVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68736
PINX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46738
PRDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39791
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Internal plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.95
YES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1592
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89434
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ileocecum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TRMT6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
B3GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07339
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
bed nucleus of the stria terminalis, medioseptal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00279
4mu8C	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
CHD7	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01355
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBX20-22328084-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
SNX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69649
CLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15946
MAF-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_01-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
RBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11139
mRNA_TUBA1A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Mean corpuscular hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.7
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.777
hsa-miR-124-3p	MiRTarBase microRNA Targets	1.0	null
A549_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196311
carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
D-Glucose	HMDB Metabolites of Enzymes	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
parasubthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60151
ARRB1	Pathway Commons Protein-Protein Interactions	1.0	null
CHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14277
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aspartate aminotransferase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3699
ZNF536	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21859
CCDC28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14572
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69933
CEBPB-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17062
EIF4G1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4082364-supp_ddu111_ddu111supp_table11.xls-Table_S1-Table_S11_MSC_wtWT1_-_top_100_genes_up-regulated_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GOLM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63233
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DL-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94621
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41101
Loperamide (hydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255138
SMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1784
CLPB	Pathway Commons Protein-Protein Interactions	1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871524
hexokinase activity	GO Molecular Function Annotations 2025	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192862
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Binimetinib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0391095
BRD-K26376097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2234
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115915
adhd	GAD Gene-Disease Associations	1.0	null
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	2.87875
BATF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25064302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66264
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.658
18614019-TableS4d	GeneSigDB Published Gene Signatures	1.0	null
DPY30	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Rapamycin_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0339414
UBE2L6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68787
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC142	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54606
NR1I3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85089
Methotrexate_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0312429
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTNNBIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69543
Cyclosporin A_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0285553
A549_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178854
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A8NY-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-REY6-2426-SM-48FF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
CDK9_knockdown_71_GSE21751	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.852104
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09782
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23968
RPS15A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87H-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HMGCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34028
BYSL	Pathway Commons Protein-Protein Interactions	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212353
Alcoholic hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3622a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
NELFA	Pathway Commons Protein-Protein Interactions	1.0	null
DKC1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.442037
IMP3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144500_7_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sinomenine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021296
ZNF426	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30281
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.6699
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4009_KD_NFAT2_SRP388821	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.5087
Artesunate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189279
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
transferase activity, transferring phosphorus-containing groups	GO Molecular Function Annotations 2015	1.0	null
GTEX-X4XY-0526-SM-46MW1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161266
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11236
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carbohydrate homeostasis	GO Biological Process Annotations 2015	1.0	null
GTEX-SUCS-1726-SM-32PM8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11528
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00999661
HK-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144584
D-Mannose	HMDB Metabolites of Enzymes	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29391
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-ATF2_UP_V1_DN-Gene_name_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66107
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
carbohydrate phosphorylation	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
occipital cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28691
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3115
A549_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0335182
HS888T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78532
Gemcitabine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0440986
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28517
Crizotinib (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248257
CCAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66246
PTDSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85252
NCIH524	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7069
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.717052
hsa-miR-4740-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29044
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960741
GTEX-VJYA-0926-SM-4KL1N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.64733
glucose metabolic process	GO Biological Process Annotations 2023	1.0	null
Fusidic acid_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0381648
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JO-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36643302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42356
CRCGN014_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07377
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05312
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
ARF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48558
TOLLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19026
BRD-K53199675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57632
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140045
Glucose metabolism	Reactome Pathways 2024	1.0	null
JVM-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Anastrozole_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0492211
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38916
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.8803
BRD-K27823380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21669
METTL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34888
CCDC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14621
BRD-K14250524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29092
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45271
Posaconazole_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0297719
CRCGN017_MCF10A.TP53.M_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18841
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39699
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4658
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A2PC-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07274638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07212
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862062
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66773
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH1_02_08	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.66297
GTEX-SNMC-1626-SM-4DM52	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41944
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tofacitinib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0115687
TBX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59064
layer 6 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20662
NOS2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6021240-oncotarget-09-27605-s009.xlsx-Sheet1-RREB1_RREB1	Rummagene Transcription Factor Associations 2026	1.0	null
PCYOX1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83569
NUP50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85684
ZDHHC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11158
Perturb_13378_KD_SFRP2_SRP115559	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.644
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168328
SNU761	CCLE Cell Line Gene Expression Profiles	1.0	1.4395
Eye disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52893
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108828
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9179
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
FOSL1	ENCODE Transcription Factor Targets	1.0	null
brain disease	GWASdb SNP-Disease Associations	1.0	0.170518
Sonidegib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0283672
CRCGN014_HEPG2_3H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16323
TMEM214	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19431
MDA-MB-175-VII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OE19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4433-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H6-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47995281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33389
BRD-K27092365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1654
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48918
GTEX-W5WG-2426-SM-4LMI6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76303
decreased a-wave amplitude	MGI Mouse Phenotype Associations 2023	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.558931
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157815
BRD-K32170456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10945
CRCGN017_MCF10A.TP53.M_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5742
Perturb_1364_OE_FOXP3_SRP074426	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bortezomib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186345
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7003
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.96085
hsa-miR-4772-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
NRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06446
BRD-K18449990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60601
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59125
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
SNU1272	CCLE Cell Line Gene CNV Profiles	1.0	1.48324
BRD-K15690866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78306
Icatibant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.96
Trametinib (DMSO_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0379425
A549_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169702
UNC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39924
GTEX-PWOO-0926-SM-2I3EC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893906
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830273
Retrosplenial area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30201
A1CF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82003
Type II diabetes mellitus	KEGG Pathways 2026	1.0	null
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K09594570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14282
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77418
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-0226-SM-3NMB9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899875
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0411
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9988
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RTLS-0726-SM-46MV4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
CTSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67338
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37614
amebiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.21175
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830273
TOV-21G	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.9388
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5069
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438329
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4436a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
451LU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RPL36A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54089081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70003
Tofacitinib (citrate)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.030627
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
outer SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.980047
Perturb_6847_KO_PHGDH_SRP261092	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.039
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82907
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
SKMM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84088
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37931
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851794
SKN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-VJYA-2026-SM-4KL1K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02227
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057162
TOMM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46643
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845208
SREK1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
HELZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55233
Aliskiren_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212009
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24123
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ropivacaine (hydrochloride monohydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0366814
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	1.0	null
KBTBD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60327
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02016
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29308
Berberine (chloride hydrate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0378862
CHEMBL:CHEMBL1707907	DGIdb Drug Targets 2026	1.0	1.01792
GTEX-VUSG-2726-SM-4KKZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892045
Benproperine (phosphate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016031
CCSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75212
BRD-K56125296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66603
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.964131
SKNMC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52541
BRD-K45010872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55729
Ehrlich ascites carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
layer 5 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31883
rnf2_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.0079
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
AP2A1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10822
POLR2A	ENCODE Transcription Factor Targets	1.0	null
QC-76-GI57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259915
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899257
monocarboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.83836
D-Galactose	HMDB Metabolites of Enzymes	1.0	null
Short Stature	DisGeNET Gene-Phenotype Associations	1.0	null
mRNA_STAT3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K62294866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73175
MELK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56256
TBX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80314
BRD-K96807219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43558
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1688
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.90359
GTEX-X3Y1-2426-SM-3P5Z7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02195
mRNA_ATF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8047
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7584
Citalopram (hydrobromide)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156245
Perturb_12371_KO_NR4A1_SRP293165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.8274
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865817
Baicalin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191496
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
AZD2858_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161495
Orbital area, medial part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34438
LS-1034	GDSC Cell Line Gene Expression Profiles	1.0	1.48642
SOX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49299
metabolic process	GO Biological Process Annotations 2015	1.0	null
DNAAF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93347
Glycemic traits (pregnancy)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.2
SUPV3L1	Pathway Commons Protein-Protein Interactions	1.0	null
GNPDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66227
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25459
BRD-K63950697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59385
AMMECR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66325
AIMP2	Pathway Commons Protein-Protein Interactions	1.0	null
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.435
CHSA0011	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.37293
Cambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40717
POLR3A	ENCODE Transcription Factor Targets	1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_upregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51266
hsa-miR-4711-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Olanzapine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0465404
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VAMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52857
generation of precursor metabolites and energy	GO Biological Process Annotations 2015	1.0	null
Tomivosertib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0386243
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06907
hsa-miR-4503	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
Entrectinib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0098244
EWSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77336
layer 4 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60466
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.86405
FUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87164
NCI-H1666	GDSC Cell Line Gene Expression Profiles	-1.0	-2.26953
OTS514_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0111523
BRD-K92579151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30461
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05505
BRD-K73769678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12199
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877352
TJP2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4735693-ncomms10380-s2.xlsx-Sheet1-Supplementary_Data_1_BESC_and_GSC_gene_signature_131_genes_2_5_fold_and_p_0_001_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41674
AKAP8	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4667_KO_Setd5_ERP110684	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.47178
SNU5	CCLE Cell Line Gene Expression Profiles	1.0	1.82986
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119481
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3341
STRAP	Pathway Commons Protein-Protein Interactions	1.0	null
LN-308 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
GSTK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57886
BRD-K11625057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68731
GTEX-OOBK-0526-SM-2HMJJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847544
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.728
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Terfenadine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0350654
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98527
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90332
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65987370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64226
Tolcapone_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245122
PCM6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63828
all	GWASdb SNP-Phenotype Associations	1.0	0.044817
Galactose metabolism	KEGG Pathways 2026	1.0	null
NOA1	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.95806
PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42445
KGN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	2.0844
lateral preoptic nucleus, PO2 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36353
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02367
LU-134-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
Trametinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0199289
Dorsal premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5836
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91714
GATA1-19941827-MEL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K63436783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46029
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2729
PMC10915192-ab-23-0304-Supplementary-Table-S6.pdf-6-TEF_TEF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5509726__F3	PFOCR Pathway Figure Associations 2023	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58298
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29053
BRD-K38955287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01667
G402_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.99027
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08352
HNRNPAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45198
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
5-Azacytidine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0527793
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Tirabrutinib (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183978
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.165217
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
C2BBE1	CCLE Cell Line Gene CNV Profiles	1.0	1.92693
Brain Lower Grade Glioma_LGG_TCGA-DB-A64Q-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.77321
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22681
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225311
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SGPL1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27884
ASCC3	Pathway Commons Protein-Protein Interactions	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3641
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
RNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7738
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19083
PNPLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14675
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.777
ZNF563	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87242
8305C	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74084
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23031
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
KC-36-DK23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338492
GTEx Lung 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-8.80088
ARHGAP39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19845
A549_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160044
JB-14-ZM03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395668
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_11474_OE_SOX9_SRP341040	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.3977
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65976
GPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84227
H3K9me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
NCIH2170	DepMap CRISPR Gene Dependency	1.0	2.37713
BRD-K68497273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40304
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2134
p3 portion of parabrachial pigmented nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03851
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15225
LSM6	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152913
mantle zone of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58751
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00933790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18268
UHRF1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16485
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4740-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
horizontal nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12396
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81137
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3255
Acute Myeloid Leukemia_LAML_TCGA-AB-2888-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
SPATS2L	Pathway Commons Protein-Protein Interactions	1.0	null
OTS514_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0284043
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Meloxicam_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00668688
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16991
FOXQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82069
hsa-miR-4326	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.893974
GTEX-XQ8I-0726-SM-4BOPU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868788
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
ARHGAP17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21689
TMEM54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7054
carbohydrate catabolic process	GO Biological Process Annotations 2023	1.0	null
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278547
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160817_0_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
PNCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70509
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.80356
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatitis	CTD Gene-Disease Associations	1.0	1.12461
BATF	ENCODE Transcription Factor Targets	1.0	null
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129388
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56612
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab10_KDM5C-KD-up-DKD-rescued-Table_10_Up-regulated_genes_in_KDM5C-KD_and_rescued_genes_in_DKD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.88132
EW-12	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73168
GTEX-S32W-1326-SM-4AD5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13396
GTEX-RWSA-0926-SM-47JXW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
AUH	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13984
BRD-A98208100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75794
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
TCL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6009
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850568
USP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33971
SPTY2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78526
BRD-K73831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19733
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CUTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09273
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22661969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72769
RAD51B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82938
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19685
GTEX-WYVS-0526-SM-3NM9W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830896
BRD-K29525414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04301
DCAF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54802
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.828575
Minodronic acid_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245798
BRD-K07035171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30358
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67D-01A-31R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CHMP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30469
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TIA1	Pathway Commons Protein-Protein Interactions	1.0	null
CNFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04028
18318837-TableS1	GeneSigDB Published Gene Signatures	1.0	null
SENP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76378
GTEX-WOFM-1626-SM-3MJFX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33367
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.23265
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.931492
GTEX-XOTO-0326-SM-4B66K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0753
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K61209548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28773
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90383
CHGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14866
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13627844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31661
Perturb_16966_KD_Ezh2_SRP050542	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.36642
GTEX-VJYA-1726-SM-3NMDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00512
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-320c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2798_KD_TRPS1_SRP125141	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.7938
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CESS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020263
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
retina	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
KDM5A	ENCODE Transcription Factor Targets	1.0	null
C1orf159	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58835
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05957
BRD-K56563145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34529
km3	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16074
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.989395
GSE164463_3_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ileum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148692,GSE148695_7_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.28364
NPLOC4	Pathway Commons Protein-Protein Interactions	1.0	null
AZD2858_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295588
GATA2-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TARS2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF3	ChEA Transcription Factor Targets	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Glucosamine 6-phosphate	HMDB Metabolites of Enzymes	1.0	null
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.905757
TAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79359
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
Vemurafenib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0102831
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ALG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97493
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
ACAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23863
BRD-K21081985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07078
HIF-1 signaling pathway	KEGG Pathways 2026	1.0	null
TIGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01599
OE21	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
NOP9	Pathway Commons Protein-Protein Interactions	1.0	null
SNRNP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41306
Ralimetinib dimesylate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0390845
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SLC8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5781
Temsirolimus_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132135
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08024
MED13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83956
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
TOX_01_331	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.5945
GSE128730_3_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nimesulide_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224065
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969255
ACHN	CCLE Cell Line Gene Expression Profiles	1.0	2.05099
TRMT61A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBED-2326-SM-47JYR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2773
rhein	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09596
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64421
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.70405
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1267
Perturb_10374_KO_Fdft1_SRP285919	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.80674
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.861
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49965
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.861665
HIF1A_01_156	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67184
GSE254526,GSE254528_0_v_1_phf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
Ebolavirus(EBOV)_7day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.55571
SDAD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RNMT	Pathway Commons Protein-Protein Interactions	1.0	null
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06697
SOCS3_DELETION_GDS1254_80_mouse_ES (embryonic stems cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956148
Brain Lower Grade Glioma_LGG_TCGA-DB-5278-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INO80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02775
SP1	ENCODE Transcription Factor Targets	1.0	null
ERK5-IN-2_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0313949
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147626_2_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PA-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_DMOG-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Relugolix_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0328804
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3978_KD_KAT5_SRP128080	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HOXD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39323
P2RY11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
H3C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50218
SNRPA	Pathway Commons Protein-Protein Interactions	1.0	null
APLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.846
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39026
BRD-K14763154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09589
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.114058
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
ASPRV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52734
496100434_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.1973
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279793
hkdc1	GeneRIF Biological Term Annotations	1.0	null
LUC7L3	Pathway Commons Protein-Protein Interactions	1.0	null
Histamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
PER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52683
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Levobupivacaine (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294757
ISHIKAWA(HERAKLIO)02ER-	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MTDH	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
HCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63789
WIPI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67623
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54199
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF3C2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
inner CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869216
GTEX-U8XE-0426-SM-3DB91	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Anisakiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
short attention span	GWASdb SNP-Phenotype Associations	1.0	0.699367
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
glucose homeostasis	GO Biological Process Annotations 2015	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.875175
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62114
Goserelin (acetate)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0411588
C3orf38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80225
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08094
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PIP4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.555
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.983334
Ebolavirus(EBOV)_3day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.79708
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
Dasatinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.8
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.045072
BRD-A99402294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19842
Perturb_3783_KD_SAP130_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SMARCAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66854
PMC8596853-41586_2021_4103_MOESM4_ESM.xlsx-ST12-Unnamed_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.86586
ARL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55874
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3915
TPBG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33507
NG25_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0349736
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A641-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 6b of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04847
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2455
NCI-H929 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
BRD-K25149224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50844
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.895554
KRAS.PROSTATE_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K89805341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77943
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195784
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09597
ZNF385C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67873
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
COASY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11307
A549_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195624
Phenytoin (sodium)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0380037
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.23389
CTAGE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9923
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
SF-295 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
specific developmental disorder	GWASdb SNP-Disease Associations	1.0	0.1694
Estrone sulfate (potassium)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175205
crotamiton-4628	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3664-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Perturb_6039_KD_MRTO4_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.07084
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HUNK_knockout_240_GSE14226	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.45727
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11332
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200281
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294124
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tetracycline (hydrochloride)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179404
SMAD3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129644
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34412
CRCGN015_MCF10A_48H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32731
T84	GDSC Cell Line Gene Expression Profiles	1.0	1.5019
Tofacitinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156984
BRD-K12836153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21903
BRD-K78400597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23732
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824694
Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KARPAS299	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42408
ADGRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47199
Attention Deficit Disorder with Hyperactivity	HuGE Navigator Gene-Phenotype Associations	1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
ZC3H15	Pathway Commons Protein-Protein Interactions	1.0	null
outer SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.974245
BRD-K68162101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21388
MAGED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51735
SQSTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21527
Binimetinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024546
Hypertrophy	CTD Gene-Disease Associations	1.0	1.70368
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPN-2926-SM-3LK65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830435
OCIC4P	DepMap CRISPR Gene Dependency	1.0	2.85566
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOV21G	CCLE Cell Line Gene Expression Profiles	1.0	1.43444
PMC7591516-41467_2020_18955_MOESM6_ESM.xlsx-Overlap_DEGs_MSC_Diff_GCTB-Gene_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20884
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Pup	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
CREBZF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65516
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30858
FARP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7577
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLD1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04438
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.76982
APOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4137
GTEX-X4XY-0926-SM-4E3JD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Demeclocycline_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0275732
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.1397
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33448
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8E_Het1A-GATA6_2d_5x_open-Gene_Name_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024072
Gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.954
GTEX-PW2O-0526-SM-2I3DX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16962
KIF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18678
hsa-miR-4691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TEX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49992
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12136
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	2.05673
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83566
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
MEG01	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79521
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PH-797804_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0389524
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.839047
Encorafenib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0315994
binding	GO Molecular Function Annotations 2015	1.0	null
KRAP_Deficiency_GDS3527_566_mouse_Brown adipose tissues	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE183251_7_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.002
BRD-K90052868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1184
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45136330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06267
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Oxaprozin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0410933
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20063
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40634
BRD-A46631350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1909
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65996
BRD-K36134372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05605
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05624
MSH6	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPB2	Pathway Commons Protein-Protein Interactions	1.0	null
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.872829
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.558059
mRNA_SUZ12_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K68618894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22038
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.25807
BRD-K52335877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49246
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
A549_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160011
Vilanterol_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0215732
PMC12502296-40246_2025_829_MOESM3_ESM.xlsx-Supplementary_Table_6-Supplementary_Table_6_Significant_eQTLs_MR_results_between_the_expression_of_druggable_genes_and_NSCLC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.74168
mRNA_FEM1B_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K80290360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27918
IRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95357
GTEX-S4P3-1226-SM-4AD4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10278
PR, GR	MotifMap Predicted Transcription Factor Targets	1.0	null
A549_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167184
GGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96437
PDZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76407
Abemaciclib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0893508
PHLDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41594
DTYMK	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
SAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.935232
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPAG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63628
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49872883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2678
PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE80182_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM27	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30858
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138281
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42609
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
NA-29-UI75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280661
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7588-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14026
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22189
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K07588901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64758
Glycolysis	Reactome Pathways 2024	1.0	null
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37326
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00383
HNRNPLL	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91373
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50522
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	0.698407
PMC9530161-41419_2022_5296_MOESM2_ESM.xlsx-Tab8_TRIM11-KD-up_genes-Table_8_Up-regulated_genes_in_TRIM11-KD_TRIM11-KD1_Control_overlap_TRIM11-KD2_Control_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62728
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NELFCD	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gigantocellular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.890875
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912931
Aliskiren_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208749
cytosol	GO Cellular Component Annotations 2015	1.0	null
Perturb_4673_KO_Taf3_SRP007832	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9584
CRCGN011_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18795
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22643
Docetaxel (Trihydrate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274537
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.893974
PHLDA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29067
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
PATU8902	CCLE Cell Line Gene CNV Profiles	1.0	1.61075
Cabozantinib (S-malate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0302588
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157221
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
IMPDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42905
Temsirolimus_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0309551
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.972283
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.692655
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39264
central part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26814
SPHK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99853
ventral linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03976
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1183
esr1_21299862_mcf7_lof_human_gpl570_gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.181379
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923391
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62449
GATA6_01_247	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.71412
decreased cellular glucose uptake	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11157
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
impaired glucose tolerance	MGI Mouse Phenotype Associations 2023	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D1FED24h_vs_D1FAST24h_259_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GNRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79704
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57441
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148041
SNRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD2_01_248	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-2.01059
Perturb_11878_OE_miR30a5p_SRP238971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
CRCGN015_HEPG2_48H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40005
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fasting	GeneRIF Biological Term Annotations	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968196
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Sarcoma_SARC_TCGA-SI-A71O-06A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEZ6L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33399
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.83046
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08675
CTCF	ENCODE Transcription Factor Targets	1.0	null
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285742
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05476
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45112
FASTKD2	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65631
BRD-K05586628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11205
GTEX-P4PP-1826-SM-2S1NT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PPP6R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28427
AZD-8055_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0187354
JAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59215
BRD-K09487932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22947
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70395
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.84061
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61323
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126364
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14226
GTEX-OIZH-0526-SM-2HMKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838013
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
NOB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23164928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33086
Brain Lower Grade Glioma_LGG_TCGA-HW-7495-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.34463
BRD-K46790201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26623
Tucatinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0263872
GTEX-XGQ4-2526-SM-4AT57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02746
HT1197_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.41697
KYSE450_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	5.92922
RTCA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16012
SLC12A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6073
COQ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9681
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chr10_69222380_T_TCA_b38	GTEx eQTL 2025	1.0	1.10772
L-Thyroxine (sodium salt pentahydrate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02921
Sinomenine_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321105
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44426
Gastric adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385176
Fenofibrate_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0117556
KMS-12-BM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
Enzalutamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE132948,GSE132949_2_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LSM14A	Pathway Commons Protein-Protein Interactions	1.0	null
PLK1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Naproxen_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0242783
HMGN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54632
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0515
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DMRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83248
protozoan form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.538604
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.684
PMC4823830-ncomms11171-s2.xlsx-GATA3_repressed_genes-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77252933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01451
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8006
Idarubicin (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0228585
GTEX-OHPL-3026-SM-3MJGS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SNU449	DepMap CRISPR Gene Dependency	1.0	6.05526
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840387
Perturb_9554_KO_Atg16l1_SRP159288	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.84622
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23836
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0943
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-1326-SM-48U1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15335
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.835307
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TUBA1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10137
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883867
Dabrafenib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242469
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05093
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PGD	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1401
RXF393	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Metabolic dysfunction-associated steatohepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24714
FHIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86227
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4498
SCAF4	Pathway Commons Protein-Protein Interactions	1.0	null
H2BC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.031
c-Kit-IN-1_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0275986
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_3969_KO_S100A2_SRP344838	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
lateral anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29232
API5	Pathway Commons Protein-Protein Interactions	1.0	null
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
G3BP2	Pathway Commons Protein-Protein Interactions	1.0	null
Afatinib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206169
primary auditory cortex (core)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72799
GTEX-XOT4-0726-SM-4GIAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.883958
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13843
Belinostat_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0287195
mRNA_NANOG_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1727
Perturb_486_KD_ELAVL1_SRP339781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34125
CAPAN2	CCLE Cell Line Gene Expression Profiles	1.0	1.77822
SPTSSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3408
Heschl's gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.981682
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.982587
BRD-K69082321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26935
PC-14	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.63408
Perturb_3934_KO_TFAP2A_SRP273704	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.8186
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.893337
ileal mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9998
Voriconazole_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212551
SURF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24453
MLL1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146078
cell part	GO Cellular Component Annotations 2015	1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08141
Beta-D-Glucose 6-phosphate	HMDB Metabolites of Enzymes	1.0	null
BRD-K86293440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89398
Macitentan_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0187834
A549_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135992
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91199
MTMR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87466
BRD-K49662642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24537
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52616
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.959235
PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45931
RHBDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89598
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83111
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19685
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98224452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23413
ARFGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4014
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CFPAC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
significant	GeneRIF Biological Term Annotations	1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
EFM-192A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UPK3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89632
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68946
Levobupivacaine (hydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0292755
EPCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40051
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CNOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64595
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43169
PMC8316210__F8	PFOCR Pathway Figure Associations 2024	1.0	null
HUH1	CCLE Cell Line Gene Expression Profiles	1.0	1.86575
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06078
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anterior cingulate area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2636
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-1326-SM-4DXU7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34236
GTEX-XBED-2426-SM-4AT4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
RPP30	Pathway Commons Protein-Protein Interactions	1.0	null
Auranofin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145941
S-Adenosyl-L-methionine (disulfate tosylate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0367796
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BBL023172	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26537
largeintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
LJI308_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206711
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.809
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.825888
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
GTEX-NPJ8-0226-SM-48TBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15984
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC36A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46821
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4742
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00308
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE1	CCLE Cell Line Gene CNV Profiles	1.0	1.79153
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67288
NID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2043
ZNF28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37156
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9971
BRD-K99000702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3924
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8E_Het1A-GATA6_2d_5x_open-Nearest_Ensembl_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.700054
late-onset retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
A549_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152159
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARL6IP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53387
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1921
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57831
Infigratinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146167
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.988506
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86065
TEX261	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38809
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136583
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K66963616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70248
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0489
REST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84617
BRD-K62072978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67503
venetoclax_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0322063
TAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.795
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05246
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11194
Cloxacillin (sodium)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179118
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45488
GTPBP10	Pathway Commons Protein-Protein Interactions	1.0	null
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ADP catabolic process	GO Biological Process Annotations 2025	1.0	null
MYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29119
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48733
HCC202	DepMap CRISPR Gene Dependency	1.0	2.39693
primary visual cortex (striate cortex, area V1/17)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14376
PMC4201688-12864_2014_6557_MOESM3_ESM.xlsx-Liver-PPAR_signaling_pathway_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44055
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164601
TMEM198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99468
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS746T	CCLE Cell Line Gene CNV Profiles	1.0	1.6423
JRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59812
Pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.672
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NO36	DepMap CRISPR Gene Dependency	1.0	10.7621
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825631
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6574
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900471
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8918
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02245
carbohydrate metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.113168
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.36562
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DHX16	Pathway Commons Protein-Protein Interactions	1.0	null
DK-MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83X-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99638698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0884
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE215086_4_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056989
Torkinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0404928
BRD-K93945680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86014
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.87014
GPKOW	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	3.15316
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175361
GSE131377_4_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0032
Defactinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.63
GSE131161_3_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03463
Perturb_4788_OE_Gadd45g_SRP315685	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.13616
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75735
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.958913
Saquinavir_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0559879
Poisoning	CTD Gene-Disease Associations	1.0	1.5528
14673169-TableA1-1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2186
ZNF728	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41212
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EWSR1_KD_GDS4962_466_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22831
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K82729862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39319
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
decreased b-wave amplitude	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K32444429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09276
ADD3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78294
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.24718
SOX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99352
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_6095_KD_ZNF207_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MARCKSL1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3sh_DEGs-DEGs_in_HeLa_IER3sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200205
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15149
Busulfan_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01235
hsa-miR-3978	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
A549_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145007
BRD-K61704278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56492
duodenum	HPA Tissue Gene Expression Profiles	1.0	1.19694
GTEX-PWCY-1026-SM-48TD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49497
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01437
BRD-K26184956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43028
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	5.68439
thin retina inner nuclear layer	MGI Mouse Phenotype Associations 2023	1.0	null
A1CF	Pathway Commons Protein-Protein Interactions	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9164
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991664
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.83624
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03606830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91214
Bisoprolol (hemifumarate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271964
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5629
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Saquinavir_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216031
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58378
Perturb_3820_KO_Satb2_SRP307573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	HPA Tissue Protein Expression Profiles	-1.0	-1.03826
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32243
BRD-K18828858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04427
SPI1	ChEA Transcription Factor Targets	1.0	null
FOXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1166
CKS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4759
L-540	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.278052
Perturb_13188_KO_Rbfox2_SRP216887	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.50821
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877411
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K40228963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33353
MTCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91853
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77425312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51127
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
developmental disorder of mental health	GWASdb SNP-Disease Associations	1.0	0.141233
NCIH929	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70352
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34625
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glucose Tolerance Test	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_6666_OE_EYA2_SRP291665	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.991685
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31832
U178	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43232
Proplastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
BRD-K95365728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18188
DUSP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49197
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91714
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.973478
SMARCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88841
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.12226
GTEX-U3ZH-0226-SM-3DB7B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04103
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35355
ESC_J1_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25169
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUJ4-1326-SM-4BOQ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DDX46	Pathway Commons Protein-Protein Interactions	1.0	null
4EGI-1_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0258698
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3102
NAA38	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.75542
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19777
BRD-K78748401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20714
CEBPA-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K02361314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65643
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS29	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7501700__F6	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-4273	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS12	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
preopto-hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5439
Binimetinib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0392214
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Indacaterol (maleate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0228
GTEX-S95S-1526-SM-2XCDH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965958
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323419
MPHOSPH10	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47853
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K01951210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04247
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MARCKS	Pathway Commons Protein-Protein Interactions	1.0	null
Paclitaxel_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192487
METTL1	Pathway Commons Protein-Protein Interactions	1.0	null
KLF5-20875108-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08668
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Berbamine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0388334
BRD-K83845379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0487
BTBD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80087
IFITM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60253
NMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54015
Lung adenocarcinoma_LUAD_TCGA-78-7154-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDGFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88412
NRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03155
Perturb_14084_KD_FGF13_SRP114701	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.33444
GTEX-XUZC-0326-SM-4BOO8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-7774-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-249-ZNF578_ZNF578	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6506_KO_PTEN_SRP299373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.40826
Guanfacine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65184008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87172
Hereditary spastic paraplegia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Volasertib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0412006
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.70715
A549_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111996
BRD-K28579021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14625
BRD-K49755501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08936
SNW1_02_49	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	5.20945
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Pioglitazone_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0467687
TPPB	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.75
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10366
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Macitentan_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0200542
Flight muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
nicotinamide nucleotide metabolic process	GO Biological Process Annotations 2025	1.0	null
POLR3A	Pathway Commons Protein-Protein Interactions	1.0	null
A 967079	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRMT112	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K53379620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65401
RPS4Y2	Pathway Commons Protein-Protein Interactions	1.0	null
PIP4K2A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866848
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21553
GSE227592_10_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.5191
KLC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84727
OVCAR8	BioGPS Cell Line Gene Expression Profiles	1.0	0.857093
GTEX-X4LF-0426-SM-3NMB5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862242
5-Fluorouracil_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.023847
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227432
intermediate stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45725
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3869
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203949
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989146
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
SUB1	Pathway Commons Protein-Protein Interactions	1.0	null
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02174
RCC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89094496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1756
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13116
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
MCAS	CCLE Cell Line Gene CNV Profiles	1.0	1.43148
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07077
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139632
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19985
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.267
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
P493-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
BRD-K77401804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01156
BRD-K33283629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28466
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
PHF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97368
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09465
Dexamethasone_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0415989
DSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6551
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.877361
BRD-K91820608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76934
Carbohydrate digestion and absorption	KEGG Pathways 2026	1.0	null
Perturb_15769_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.9666
GTEX-WFG8-1626-SM-4LVMB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07105
PVRIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54347
CTNND1	Pathway Commons Protein-Protein Interactions	1.0	null
ZMYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75331
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48408404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03577
Secondary motor area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06489
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188991
Perturb_6605_KO_STK11|KEAP1_ERP124775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.6498
PMC10251551-12885_2023_11010_MOESM4_ESM.pdf-0-SOX9_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59893572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43076
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0515
RALB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53796
POP1	Pathway Commons Protein-Protein Interactions	1.0	null
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44337
ZNF134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.514
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCAR1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98728
MPST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16066
XYLT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18985
hsa-miR-3622b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.983334
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12142_KO_Lgals9_ERP122370	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.60397
GJB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12938
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Budesonide_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0419709
TTLL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71007
CRLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71564
J82	GDSC Cell Line Gene Expression Profiles	-1.0	-2.05818
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204897
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RI-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8346_KD_IGF2BP1_SRP252414	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.96311
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular chemical homeostasis	GO Biological Process Annotations 2015	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.626
GSE200099_2_v_0_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91941
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
COBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76209
Prostate adenocarcinoma_PRAD_TCGA-Y6-A8TL-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14407_KD_PGK1_SRP252531	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.4838
STAT3_01_84	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.47263
Neratinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0156493
CCDC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15518
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
KIF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09943
Perturb_5971_KD_TAF15_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.69402
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNASEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70563
BRD-K44858727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64385
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840387
EX229_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0745915
TCIRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63435
hsa-miR-4742-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Fluvoxamine (maleate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214206
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.03295
RING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71584
NCIH716	DepMap CRISPR Gene Dependency	1.0	6.05035
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.14926
Elagolix sodium_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0207966
SRSF6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18179332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62802
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5704
Lysosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.519
posteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54625
Liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
transverse gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.959264
Posterior parietal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2404
hexose metabolic process	GO Biological Process Annotations 2023	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-PPARA_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
H4C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16595
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16733
CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Idarubicin (hydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244445
Bimatoprost_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016651
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.904085
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IB-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACO2	CCLE Cell Line Gene CNV Profiles	1.0	1.78312
SNU1079	CCLE Cell Line Gene Expression Profiles	1.0	2.45543
Naproxen_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226999
NCIH2052_PLEURA	CCLE Cell Line Proteomics	1.0	2.84504
AICDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9433
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136407
smallintestine_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.27029
GTEX-OHPK-1726-SM-48TC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00233
GTEX-WEY5-0526-SM-3GIKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920858
CCDC90B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77832
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02451
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65511
REC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44758
GSE110178_2_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0328589
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96555
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14347
A549_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227234
BRD-K27653895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33709
HDAC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08096
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50838
MTHFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15163
PSME3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97219
Atrophy	CTD Gene-Disease Associations	1.0	1.57522
TBX20-22080862-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
Sepsis_Splenocyte_GSE4479	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.61551
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29142
BRD-K37000177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44326
Oleic acid_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0410768
Everolimus_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295695
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3833_KO_Satb2_SRP307575	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.03876
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34125
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2759
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3194-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K29379469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18132
BRD-K03243737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2379
APEX1	Pathway Commons Protein-Protein Interactions	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10495
GSE240896,GSE240899_5_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.842396
HCFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69033
hippocampus (hippocampal formation)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48584
496100539_HIP_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.09493
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S01_LF_C1_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
RBMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45078
GSE193027_1_v_0_krt19_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QESD-1726-SM-2S1R7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02977
GSE148658_1_v_0_six6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.629
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
POLR2B	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22725
GATA4-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.84205
OE33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PFI-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177926
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.891513
GSE182680,GSE182683_10_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Azithromycin (hydrate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0310904
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8368
GSE130715_1_v_0_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53379
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20_vs_D1_815_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837275
inner SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15187
BRD-K59821372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77888
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K38273665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51246
Larotrectinib sulfate_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240734
PMC11961801-12672_2025_2262_MOESM2_ESM.xlsx-Sheet_1-WGCNA_AND_DEGs_NOT_CSGs_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K40745976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15384
GSE149760_0_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K27026825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83643
intestinal mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_JQ1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150228
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.94024
Perturb_5891_KD_C5orf41_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.43424
ALPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75942
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30625
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6754917-4202563.f1.docx-1-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01953
monosaccharide metabolic process	GO Biological Process Annotations 2015	1.0	null
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
NDUFA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18045
NP8	DepMap CRISPR Gene Dependency	1.0	5.32155
Perturb_5892_KD_CBX1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.90149
BMPR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71505
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890563
NHEK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39188
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.915661
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Elimusertib hydrochloride_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0320969
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.87153
Budesonide_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210278
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-dep_XBP1_signature-ABLIM3_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
CCLFPEDS0001T	DepMap CRISPR Gene Dependency	1.0	2.33493
BRD-K37803976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52128
Glycogen synthesis and degradation	WikiPathways Pathways 2024	1.0	null
SF3A1	Pathway Commons Protein-Protein Interactions	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-134-HOXC12_HOXC12	Rummagene Transcription Factor Associations 2026	1.0	null
caco2	HPA Cell Line Gene Expression Profiles	1.0	1.25116
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19634
RAB9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69167
NMT1	Pathway Commons Protein-Protein Interactions	1.0	null
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.428
Ovary	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.28881
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180871
mRNA_GADD45A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TARDBP_02_169	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63743
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.836531
Elimusertib hydrochloride_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231514
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
intermediate stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36449
SBI-0640756_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0405121
SNAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35967
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tideglusib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
RPS4Y1	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.923666
D283MED	CCLE Cell Line Gene Expression Profiles	1.0	2.9196
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MEPCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33175
G3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNRNPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69445
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.859293
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05365
CELSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80644
ABT1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_1365_OE_FOXP3_SRP074426	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.7496
oxolamine-6624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82215
BRD-K92432769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8851
lateral periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.34182
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
Dexamethasone_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.022721
GTEX-TMMY-0526-SM-33HBC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881957
BRD-K59159023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26469
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.868
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75582
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166111
Supramammillary nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31462
CAKI1	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
maturity-onset diabetes of the young type 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
PMC4038464__F3	PFOCR Pathway Figure Associations 2023	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	2.74409
PERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23623
GTEX-S4Q7-0426-SM-3K2BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20292
ETS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08153
CHEMBL2041153	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
hel	HPA Cell Line Gene Expression Profiles	-1.0	-1.15888
PNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8152
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11728
AKT1_OE_GDS2308_498_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_8459_KO_SOX9_SRP399992	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
fructokinase activity	GO Molecular Function Annotations 2025	1.0	null
TMED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55973
parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.355604
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
CD74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36201
Perturb_1426_OE_Mir10a_ERP106848	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61989
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Econazole_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0383278
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.682
ARPC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14833
Perturb_5180_KO_Lb1/Lmnb2/Lmna_SRP092589	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.7686
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15813
6-Aminochrysene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.6
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251969
SUB1_02_161	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.16993
TRIM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26031
TOX4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37703
Ralimetinib dimesylate_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0246638
BRD-K62152527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77256
SKUT1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19858
Tucatinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232837
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42077
fisetin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16133
Pancreatic islet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.662
HARS	Pathway Commons Protein-Protein Interactions	1.0	null
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65513
BRD-K94411351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84992
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63027
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MORCPR	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03407
GTEX-QLQW-1426-SM-2S1QU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975583
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12047
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K99446825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08577
BRD-K24004917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11879
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140693
BRD-K25993054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0479
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2374
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K61711624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00917
RAVER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03953
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134353
PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
POR_KO_GDS1678_762_mouse_Jejunum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56126
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GTEX-QLQW-0426-SM-447A7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90597
CRCGN008_HEPG2_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05055
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.152
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2317
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RXF393	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
CLDN1_OE_GDS3510_393_human_CL1-5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11014
GTEX-WOFM-0726-SM-3MJF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
LJI308_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0392968
STAT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22646
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
HEXIM1	Pathway Commons Protein-Protein Interactions	1.0	null
PTF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55654
DDX42	Pathway Commons Protein-Protein Interactions	1.0	null
H1-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71125
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K32854540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57247
SAS acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
MITF_02_85	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.6845
Perturb_12740_KD_WDR5_SRP261594	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.3078
BRD-K70543679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02478
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192737
EIF3A	Pathway Commons Protein-Protein Interactions	1.0	null
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.966837
PES1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13396
Ataluren_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0387838
nicotine_mus musculus_gpl1261_gse31004	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell lysate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306805
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CIRBP	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19292
Verapamil_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0409969
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21131
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K92468187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13788
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05997
BRD-K69668461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21995
EIF3C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59865704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06724
N6AMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50084
BRD-K72083510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28768
Regorafenib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245537
FOSL2	ENCODE Transcription Factor Targets	1.0	null
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
A3-KAW	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.96388
Lung adenocarcinoma_LUAD_TCGA-86-7954-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05483
TSN	Pathway Commons Protein-Protein Interactions	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE249544,GSE249637_6_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08678
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZRANB2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
A549_MLN8054_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0326324
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869071
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.897906
Lapatinib ditosylate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266865
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211151_2_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Afatinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0297145
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.96249
BATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74987
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26234
NCI-H2023	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146223
LS1034	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.05836
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3826
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62087
cellular glucose homeostasis	GO Biological Process Annotations 2015	1.0	null
DT-061_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0276395
A549_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100404
Erythromycin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00758387
Retrosplenial area, ventral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01919
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50347
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34894
OS-RC-2	GDSC Cell Line Gene Expression Profiles	1.0	1.6227
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828825
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44735
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27684
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, trunk, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08244
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03655
BRD-K79148949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21046
CES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37544
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043296
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
Fundus of striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08361
PMC7501700__F6	PFOCR Pathway Figure Associations 2024	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.794899
A549_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141958
A549_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157262
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50154
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.915569
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.01146
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.969
PGR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56461
BRD-K68379391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16812
TRMT2A	Pathway Commons Protein-Protein Interactions	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050621
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19305
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.942462
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3385
Perturb_14282_KD_NUAK1_ERP105393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
LM3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATP5MK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1848
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Hexokinase	InterPro Predicted Protein Domain Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.977445
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44551
A549_TMP195_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119845
frontal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11848
LTBR_INHIBITION - 1 Day_GDS2004_733_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
EVI5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59448
Pancreatic adenocarcinoma_PAAD_TCGA-IB-8127-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mb03	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
Bed nuclei of the stria terminalis, anterior division, ventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4915
Temsirolimus_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255978
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48806
LDB1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SF3A3	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.34729
MRM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4QT-1726-SM-2S1NQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925619
Small_Intestine-mature enterocyte	Tabula Sapiens Gene-Cell Associations	1.0	0.48838
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84M-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TD-40-ZR64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265423
GTEX-OHPM-1426-SM-3TW8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972391
carbohydrate catabolic process	GO Biological Process Annotations 2015	1.0	null
Non-Alcoholic Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
FLOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29663
DRG1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Celecoxib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0102193
Neratinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0239404
SUPT11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39282
ETS1_01_76	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.36841
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
prostate_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
BMI-1_DEPLETION_GDS2445_115_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-P4QS-1826-SM-2S1NI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
BRD-K71274071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.83675
BRD-K95578456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79792
ZNF789	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91925
GAS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77188
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147528
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051153
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96708
LARP1	Pathway Commons Protein-Protein Interactions	1.0	null
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3888
TMEM126B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67292
CSDE1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	3.04413
FOXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20477
IP6K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79516
COX5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47355
RXRB	Pathway Commons Protein-Protein Interactions	1.0	null
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182539
MEL-HO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
fructokinase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-XYKS-0526-SM-4BRW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5234
SW1783_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.48608
A549_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217301
Keratoconus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900321
Gestational Diabetes	DisGeNET Gene-Phenotype Associations	1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	1.0	1.35864
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06824
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83648
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
4EGI-1_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270187
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Mesothelioma_MESO_TCGA-LK-A4NW-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMRC20	CCLE Cell Line Gene Expression Profiles	1.0	1.50067
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45432
BRD-K96449536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08652
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7422
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
DAGLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64452
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29047
HDLBP	Pathway Commons Protein-Protein Interactions	1.0	null
RBM3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_352_OE_JUNB_SRP287831	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852485
periventricular stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62195
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0914
BRD-K94936556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10353
ESPNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42107
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDST8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
CHEMBL:CHEMBL1503190	DGIdb Drug Targets 2026	1.0	1.01792
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fenofibrate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0234699
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19927
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
DUSP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44206
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.933522
Chlorhexidine (diacetate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284199
OVCAR4	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.34301
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43364707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09284
NUP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18627
Glycosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
CHST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6506
Retinoic acid_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0108715
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.11639
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-PITX1-HIT_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
5-Azacytidine_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196661
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K30372674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61593
GTEX-WHPG-1426-SM-3NMBB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917035
GSE226408_2_v_3_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.0
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08352
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15024
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.015754
CDR2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43382
LIG3	Pathway Commons Protein-Protein Interactions	1.0	null
TSKU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03604
DMD_Deficiency_GDS2996_614_mouse_Cardiac muscles from 10.5-month (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PTGFRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26532
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prelimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55756
HCC1428	CCLE Cell Line Gene CNV Profiles	1.0	1.55713
Memory Disorders	CTD Gene-Disease Associations	1.0	1.32637
BRD-K91897530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0672
SBI-0640756_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0468025
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052484
Tolcapone_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0259337
MDA-MB-436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FHOD1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-1526-SM-4KKZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
HDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73941
GTEX-XYKS-2526-SM-4BOPX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23257
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05228
AE-13-CX28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373569
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3732
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44199
253J	CCLE Cell Line Gene Expression Profiles	1.0	1.66387
preoptic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1701
MEF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4705
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.472
ZNRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82246
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20361257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26937
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45037
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
blastocysts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959223
EXTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01755
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCV JFH-1_24Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.28202
organophosphate metabolic process	GO Biological Process Annotations 2025	1.0	null
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.991138
GTEX-SE5C-1526-SM-4BRWU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840642
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1347
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37339
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22966
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927219
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55438
GSE145323,GSE145324_1_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.03322
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vincristine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0471945
Terfenadine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0324282
polymorph layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0057
PMC8851354-Table_5.xlsx-FUS-DDIT3_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_FUS-DDIT3_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
RMC-6236_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206972
PA2G4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11414
Lung adenocarcinoma_LUAD_TCGA-55-8089-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRPR	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15777_KO_Nmnat1_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.2193
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.452
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Gallic acid (hydrate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0252047
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dihydroartemisinin_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232093
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0327704
PMC7591516-41467_2020_18955_MOESM6_ESM.xlsx-Overlap_DEGs_MSC_Diff_GCTB-Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.33
sublayer 6b of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14856
GTEX-S3XE-1926-SM-3K2B3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03865
Perturb_4587_KO_Socs3_SRP074146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.40401
Bed nucleus of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56248
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
Brimonidine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210018
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39139
AKAP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3496
Resveratrol_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0191687
PPARD	ChEA Transcription Factor Targets	1.0	null
EOL-1-CELL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PLZ6-0926-SM-3P5ZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17549
BRD-K17675523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42875
hsa-miR-4429	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
lingual gyrus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867428
glucose 6-phosphate metabolic process	GO Biological Process Annotations 2023	1.0	null
Baicalin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214267
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78691
Perturb_6761_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.75479
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Cytarabine_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0367471
Area postrema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S23_LF_C1_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-0426-SM-32PMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48855
A549_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211005
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79902
A549_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167283
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06044
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202864
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16165
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
esophagus_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
Perturb_11075_KO_Rictor_SRP097622	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.8312
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Birth Weight	DisGeNET Gene-Phenotype Associations	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039674
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.21812
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175096
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216325
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.825
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62453
Endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.671
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.155113
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205582
GGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49481
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865514
INAVA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80292
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25391
BRD-K99022424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22281
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YX-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8175556-42003_2021_2140_MOESM6_ESM.txt--BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
Posaconazole_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0380235
crizotinib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0205045
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
superior parietal lobule, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.90679
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.97195
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27123
NCIH2172_LUNG	CCLE Cell Line Proteomics	1.0	5.90468
Gemfibrozil_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0376722
GTEX-QDVN-0626-SM-2I3FP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913924
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Atazanavir (sulfate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0458493
pancreas	HPA Tissue Protein Expression Profiles	-1.0	-0.915569
ZNF473	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7009
GTEX-Q734-0526-SM-2I3EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02703
BRD-K21990111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56202
SH3D21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98034
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A46R-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CCT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42327
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBM19	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
UTX-26944678-CHIP-SEQ-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221657
CREBBP	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03884
HI-TOPK-032_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0371409
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.122
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05054
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61981
Perturb_6377_KD_lncRNAHUMT_SRP326145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Capivasertib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0314929
ADISSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57564
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GNA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7578
BRD-K28795679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4041
CUX1	ENCODE Transcription Factor Targets	1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-6215-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventral striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39385
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229973_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41368
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16788
SNAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80207
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
GSE197948_2_v_1_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	1.0	2.03695
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.0766
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152613
superficial stratum of OCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28477
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5303
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04384
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MRPS12	Pathway Commons Protein-Protein Interactions	1.0	null
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34134
EIF4B	Pathway Commons Protein-Protein Interactions	1.0	null
genomewide	GeneRIF Biological Term Annotations	1.0	null
BRD-K33400588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75039
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Selinexor _SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0356602
BRD-K64567083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36974
CNP	Pathway Commons Protein-Protein Interactions	1.0	null
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
FOXA2	ENCODE Transcription Factor Targets	1.0	null
ABHD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74356
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4264
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2228	GDSC Cell Line Gene Expression Profiles	1.0	1.7028
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ileal mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYBL2	ENCODE Transcription Factor Targets	1.0	null
17683608-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
HEC6	CCLE Cell Line Gene Expression Profiles	1.0	1.35755
PrPC_KO_GDS4352_359_mouse_Developing hippocampus from adults (3-mo-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SLC16A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31552
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EFO21	CCLE Cell Line Gene Expression Profiles	1.0	1.80134
BRD-K00530465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5176
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XV7Q-0926-SM-4BRVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1423
hsa-miR-770-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10099
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
PUS1	Pathway Commons Protein-Protein Interactions	1.0	null
ATAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38839
Acute Myeloid Leukemia_LAML_TCGA-AB-2859-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IQCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08041
Mesothelioma_MESO_TCGA-MQ-A4LI-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_2-Methoxyestradiol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117489
ECPAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7001
Posaconazole_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0357767
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.09646
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57965
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914572
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
BRD-K70856965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78722
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33343
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.917718
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.65571
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88394
GTEX-SIU7-0526-SM-3NM8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47378
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24714
TTLL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05207
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80921954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25271
TBL2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE157233_2_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA4	ChEA Transcription Factor Targets	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831008
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB-20176806-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54558
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.809
TNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17189
BRD-K14570970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02117
H4/H2A histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32337
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.39817
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52143
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5460-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33294
Prestwick-664-3715	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_6603_KO_KEAP1_ERP124775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.06
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Torkinib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0306773
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.893974
KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.863985
SAP30	ENCODE Transcription Factor Targets	1.0	null
DHRS2	Pathway Commons Protein-Protein Interactions	1.0	null
SR	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.99026
KYSE-220	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56194
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF385A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74204
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IF-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69491845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02909
Pentamidine (isethionate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0125257
INS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
Neuroblastoma	dbGAP Gene-Trait Associations	1.0	0.337794
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
A549_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189439
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.01977
PF-06260933_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0326853
THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.42545
KP-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.37365
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Perturb_6011_KD_ERH_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.38995
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14666
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11516621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55915
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10423475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00367
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039942
Mannose 6-phosphate	HMDB Metabolites of Enzymes	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2706-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04928505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16408
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.855747
NCIH28	CCLE Cell Line Gene Expression Profiles	1.0	1.56245
PEG10	Pathway Commons Protein-Protein Interactions	1.0	null
GTF3C2	ENCODE Transcription Factor Targets	1.0	null
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
Methyl aminolevulinate (hydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219311
Sinomenine_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136457
4-Benzylpyridine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
BRD-K71452779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26231
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11113
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134665
S100PBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06672
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54985
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.806
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_33_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31897
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.01168
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238921
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
A549_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163599
PPP1R2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.663
RCC10RGB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RAJI	DepMap CRISPR Gene Dependency	1.0	2.05138
LSM7	Pathway Commons Protein-Protein Interactions	1.0	null
CKAP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28762
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
Lung adenocarcinoma_LUAD_TCGA-05-5425-01A-02R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93900188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44462
ADAMTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17553
c-Kit-IN-1_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0324973
BRD-K21232462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07502
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11152
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
postcentral gyrus, right, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4339
SEPTIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44267
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
KSR2_knockout_60_GSE17923	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.994216
Futibatinib_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0211172
C2CD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10494
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52778
Perturb_2176_KO_Nlrp3_SRP366634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.94997
Sulfisoxazole_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.018745
CPSF1	Pathway Commons Protein-Protein Interactions	1.0	null
ileum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20971
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54776
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40475
Triclosan_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234132
AMBRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73803
ADAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38351
glucokinase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K90960272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45032
CL34	CCLE Cell Line Gene Expression Profiles	1.0	1.56446
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174649
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.721243
pyruvate metabolic process	GO Biological Process Annotations 2015	1.0	null
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
flumetasone-3610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATRAID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28415
FOSL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLT-13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58405
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.946046
NCI-SNU-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174621
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19997
ARHGEF35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28593
MAP4K4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247971
GTEX-OXRK-0426-SM-3NB2E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934912
BRD-K77417197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.78593
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281619
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11236
TMEM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25735
BRD-K83180232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14777
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR3D	Pathway Commons Protein-Protein Interactions	1.0	null
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273787
Perturb_13975_KO_H3f3a_ERP109384	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76591
Talc_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0223569
STAT5A	ENCODE Transcription Factor Targets	1.0	null
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110538
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
efo21	HPA Cell Line Gene Expression Profiles	1.0	1.05427
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21176
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF2S1	Pathway Commons Protein-Protein Interactions	1.0	null
Hyperinsulinemic hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
heart	GTEx Tissue Gene Expression Profiles	-1.0	-1.06981
BRD-K01278504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63567
NVP-BHG712_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270255
RGS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27163
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3835
SK-MEL-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
GSE249544,GSE249637_8_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8584-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMURF2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3455_KO_Mecp2_SRP017936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.42089
DEOXYVASICINONE	DGIdb Drug Targets 2026	1.0	0.370154
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28703
BCLAF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01853144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05581
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6773-01A-41R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 2 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0952
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Abemaciclib_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0349525
Elagolix sodium_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0376546
Hyperglycemia	DisGeNET Gene-Disease Associations	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS422	DepMap CRISPR Gene Dependency	1.0	2.43803
SH3PXD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01766
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K65737790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0372
Beta-D-Fructose 6-phosphate	HMDB Metabolites of Enzymes	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11236
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA4-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27975
NOLC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
pyridine nucleotide catabolic process	GO Biological Process Annotations 2025	1.0	null
CRCGN015_HEPG2_48H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2244
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K36055854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15838
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4464	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61385
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226429
EEF1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2911
Verapamil_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.028066
Futibatinib_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232362
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934651
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_DMOG-HIF1_-related_miRNA_targets_expression_during_hypoxia_based_on_micorarray_FC_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SMG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60408
MYOG	ENCODE Transcription Factor Targets	1.0	null
c-Kit-IN-1_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295654
LAMA2_Deficiency_GDS1778_747_mouse_Diaphragm (from dystrophia muscularis -dy/dy- mouse model)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ANP32B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33643
LSM3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Shigellosis	KEGG Pathways 2026	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81291
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hexokinase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K02809100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5244
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.829129
BRD-K72609226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04478
external cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0422
glycolytic process	GO Biological Process Annotations 2023	1.0	null
NSUN2	Pathway Commons Protein-Protein Interactions	1.0	null
Carbamazepine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249381
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
HARS2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bicalutamide_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0308691
posteroventral (inferior) parietal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14114
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150863
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193292
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3311
RRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40371
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Everolimus_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.041674
intracellular part	GO Cellular Component Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.722
FEZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52078
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4538_KO_Mtf2_SRP103933	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.71701
Mifepristone_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0293099
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233317
GTEX-UPIC-1726-SM-4IHKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27576
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Torkinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0455566
PRKCI	Pathway Commons Protein-Protein Interactions	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.892882
GTEX-O5YV-1826-SM-2YUNI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929362
Quinestrol_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0133445
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I2-06A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71817712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20337
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
mRNA_ETV3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CSNK2B	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147173
Perturb_3764_KD_CHD7_SRP352803	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.74611
BRD-K01067435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20168
TJP1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
progesterone_homo sapiens_gpl570_gse29435	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068648
nucleus of the stria terminalis, medial division, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11923
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12528
ZKSCAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54049
CDC5L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04227
GTEX-XUZC-1026-SM-4BOPY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
XIAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23656
Anteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28975
FADS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72995
Mitoxantrone (dihydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0197834
Ixazomib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0459081
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRB7	Pathway Commons Protein-Protein Interactions	1.0	null
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.33983
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5591
Perturb_5192_KO_Nanog_SRP116119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.74173
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.964823
Perturb_14715_KO_Tbx3_SRP305624	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.7219
prostate_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12776
A549_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169854
MTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61078
disease	GWASdb SNP-Disease Associations	1.0	0.047609
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VO-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52052
TM9SF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8779
C14orf166	Pathway Commons Protein-Protein Interactions	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052069
Intrahepatic cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77711
ZBTB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02947
Bentamapimod_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0314445
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.26365
venetoclax_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0485247
Neratinib (maleate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.03196
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Fusidic acid_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237989
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6181
RNF216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79138
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
HS281T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49296
Capmatinib_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0472631
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
SHP77	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36297
BRD-K65829768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77423
phosphate-containing compound metabolic process	GO Biological Process Annotations 2025	1.0	null
H3C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42201
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
TIMM21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44181
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33156
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7711-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.831973
kinase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117928
RECQL	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1R10	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29762
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.859293
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20445
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.42786
BRD-K36697652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27787
HTR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57928
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155661
Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35659
PDCD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00549
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162276_4_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BEL-7404 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
Epimastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.877098
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urapidil-3078	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2236
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14136
ZNF625	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.812
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047099
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82117
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24551
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.28214
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.904626
PMC6122955-elife-33947-supp2.xlsx-HNF1A_activated_bound_survival-HNF1A-upregulated_and_-bound_genes_association_between_gene_expression_and_survival_in_TCGA_PAAD_tumors_-_related_to_Figure_7E_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null