association	dataset	threshold value	standardized value
10348_ZNF423_ENST00000262383.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568462
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2763
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
IMR-90 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0342
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4346
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA splicing, via spliceosome	GO Biological Process Annotations 2025	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE85880,GSE85881_4_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.3586
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1528
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16905
Ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9492
CIAO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04544
496100502_TCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06146
KCMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26338
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5178
PMC5414054-ncomms15013-s11.xlsx-SupplementaryData10-Supplementary_Data_10_Genes_differentially_expressed_due_to_infection_in_IRF5-_-_compared_to_parent_KOLF2_cells_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	GO Biological Process Annotations 2025	1.0	null
VPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92776
BARX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42026
WDR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22377
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE85880,GSE85881_4_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149760_0_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF148	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97339
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32082
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2985
UCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1219
FOXH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03659
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3573
SCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43254
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10626
GIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13714
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.19455
KDR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34121
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.13
MDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6003
MTFR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27116
TIMELESS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12313
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16394
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4652
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9096
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5419
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16991
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ACAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42883
RSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16334
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9963
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3399
SLC35A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17629
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
SRRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27113
ATP2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62177
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.3942
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60117
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2152
PMC7190674-41467_2020_15815_MOESM3_ESM.xlsx-Tab3-Tab3_Detailed_information_of_the_SRG_mutational_landscape_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EXOSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55041
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5635
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3069
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0755
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
TRERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23943
GATA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41235
B3GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52968
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12751
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51135
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04692
TBCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72068
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Henles loop	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
496100283_PCx_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25008
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8497
NUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81992
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4342
ZNF337	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63224
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16056
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100534_FWM_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50191
TTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25298
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20994
GSE143782_6_v_8_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50733
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	4.41049
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6162
MTSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16393
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9885
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0697
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1237
QPRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02218
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9959
496100531_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.09711
FAM210A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25548
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3567
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
MATN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.855
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6661
AURKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22499
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
NDUFB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07428
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4618
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1658
496100419_TCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18704
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3009
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.85807
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648223
ZNF827	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0406
NDRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29527
PSMA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59082
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.182
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2527
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9348
KAT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11112
SUPT4H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09034
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6314
DLGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36078
DAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30575
5054_MICAL3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557618
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85498
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6193
MYO10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07289
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6692
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOWAHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48401
TMEM214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01124
CEP170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27882
Fetal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.23
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.911
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22921
TUT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24274
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8689
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4707
Spliceosome	KEGG Pathways 2026	1.0	null
TBX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12397
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83205
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2127
HSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61342
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1179
TIMM21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67754
MCOLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05835
YIPF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02544
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1189
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0964
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.2175
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MASTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43213
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.057
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
ACKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05421
KCNQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15283
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1393
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.549574
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4396
PRPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34825
TCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07641
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45307
1536_CFL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601912
Amyotrophic lateral sclerosis	KEGG Pathways 2026	1.0	null
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6795
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2262
STAMBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84002
ZNF629	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37706
DHX36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63445
ZHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07641
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9159
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9328
H3C8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36406
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1752
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9617
CDC37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00022
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Catalytic step 2 spliceosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
CYC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65313
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1376
GSE143782_6_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.565
USP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25039
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9408
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02443
496100535_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14687
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA 3'-UTR binding	GO Molecular Function Annotations 2025	1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
KCNK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34884
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3534
PLCXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42247
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19887
NPIPB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76026
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
NMRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6737
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF146	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32703
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6375
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1646
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
IFT52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21972
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2591
496100291_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25896
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7021759-41467_2020_14682_MOESM8_ESM.xlsx-Upregulated_Genes-Table_S5_Upregulated_genes_in_MYCN_amplified_neuroblastoma_relative_to_non-amplified_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
3631_HARS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509568
Spliceosomal complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5267
CTSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03192
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5007
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.631
REM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14913
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1358
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GUF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27032
10062_ZEB2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563189
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
METTL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23723
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8198
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRIPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05294
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6137
GGCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84393
SBK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74633
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
MRPS18B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15116
DHX32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0382
GSE129241_3_v_6_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01124
RNF185	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06308
496100585_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14668
RHBDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45667
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIP13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60481
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6795_PRPF38B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.756039
ZNF90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31049
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.931751
FLVCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8669
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FBXL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49464
Dendritic lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.847
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29762
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0442
PISD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24864
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8822
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3842
PMC6242972-41467_2018_6699_MOESM8_ESM.xlsx-Sheet1-Supplementary_Data_5_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_CLB-GA_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1907
6655_PPP1R12B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507335
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8357
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7846
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.6444
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190316,GSE190324_6_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3283
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4083
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7563
mRNA processing	GO Biological Process Annotations 2025	1.0	null
CDH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71777
SERPINB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19324
DAZAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06161
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32841
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5646
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32608
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2629
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582965
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
TUNAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31132
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6376
5005_METTL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51049
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7203
DDOST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28345
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0029
GSE210101,GSE210114_11_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6424
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3161
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20961
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
11112_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66234
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5883
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5041
CDKN2AIPNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16883
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3934
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30989
NUDCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.41896
OBSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22471
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NDST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38886
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7545
ZC3H7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05052
DENND4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26256
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624817
KCTD21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57171
MINPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1229
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3621
PIMREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72641
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19585
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
SMARCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37791
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
TRRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.026
OSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33781
mRNA binding	GO Molecular Function Annotations 2025	1.0	null
HAGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22445
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630008
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.810281
SUMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12386
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
EIF4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30403
PABIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02507