association	dataset	threshold value	standardized value
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IGSF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54563
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146949
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_8C-MLX_3T3_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.863642
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148722
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
choroidal sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
SDC4	Pathway Commons Protein-Protein Interactions	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14468
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cerebellar cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49208
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0466318
MCF7_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163177
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.23296
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.36758
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16112
hsa-miR-539	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
IZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21877
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20957
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	1.33297
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28515
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
neoplasm of head and neck	GWASdb SNP-Phenotype Associations	1.0	0.225071
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dermal microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30894
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50041
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.842454
Mesenchymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
abnormality of male external genitalia	GWASdb SNP-Phenotype Associations	1.0	0.260456
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318741
PMC8755441-mmc3.xlsx-IRF7-Up-JARID2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67695
Diseases of glycosylation	Reactome Pathways 2014	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7562-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85927
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EOMES	ChEA Transcription Factor Targets	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.86614
Kidney Chromophobe_KICH_TCGA-KN-8419-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus subputaminalis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12291
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32838
MCF7_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165408
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.934367
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.00147
Adrenocortical carcinoma_ACC_TCGA-PA-A5YG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.775
MCF7_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306924
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236183
periventricular stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33573
MCF7_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168577
MCF7_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120076
CALU-6	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14593
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58181
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055052
MCF7_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0406655
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269138
Breast pericanalicular fibroadenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923309
H3K27me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EZH2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.33966
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16725
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166149
MCF7_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100125
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73R-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sclerosis of metaphyses of the upper limbs	GWASdb SNP-Phenotype Associations	1.0	0.824663
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0791
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23485
TP63	ChEA Transcription Factor Targets	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875077
H3K9me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57907
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.47711
GSE148494,GSE182513_1_v_0_hoxd13_human	RummaGEO Gene Perturbation Signatures	1.0	null
Plicamycin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0118496
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927048
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.674694
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02921
CREM	ChEA Transcription Factor Targets	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GBX2	ChEA Transcription Factor Targets	1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01798
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03359
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149386
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4205_KO_Top1_SRP072888	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.27899
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0362855
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59583
Purkinje cell layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24224
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258911
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150137
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3859
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
golgi apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.319328
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07537
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64319
GSE130401_6_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11110418-12864_2024_10412_MOESM1_ESM.xlsx-S_Table_3-Supplementary_Table_3_Detailes_of_the_instrumental_variables_of_plasma_proteins_used_in_replication_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41598
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32635
artery disease	GWASdb SNP-Disease Associations	1.0	0.199921
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132966
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00219
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37771
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7370-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01465
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02975
KDM5B	ENCODE Transcription Factor Targets	1.0	null
MCF7_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014294
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40766
Entrectinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0159837
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0319873
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071992
abnormality of limb bone morphology	GWASdb SNP-Phenotype Associations	1.0	0.824663
Primary visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21808
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7069
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44664
CAPAN1	DepMap CRISPR Gene Dependency	1.0	2.01961
Disease	Reactome Pathways 2014	1.0	null
Vinblastine (sulfate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294801
NCIH716	CCLE Cell Line Gene Expression Profiles	1.0	2.6521
GTEX-OOBJ-1826-SM-3NB1C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862504
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159849
superficial stratum of PrS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0356
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.3774
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.18495
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10175
MCF7_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231802
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr13_95995703_A_G_b38	GTEx eQTL 2025	1.0	1.45168
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2415
NCIH526	CCLE Cell Line Gene Expression Profiles	1.0	1.57863
abnormality of the hand	GWASdb SNP-Phenotype Associations	1.0	0.824663
Defective CHST3 causes SEDCJD	Reactome Pathways 2014	1.0	null
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MPS IIID - Sanfilippo syndrome D	Reactome Pathways 2014	1.0	null
Narcolepsy	DisGeNET Gene-Disease Associations	1.0	null
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141166
MCF7_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191881
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189389
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glomerulosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
Cerebellum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37198
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.13118
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49461
chp126	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103237
Anethole trithione_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268654
DEL	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04756
hsa-miR-4766-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Perturb_13878_OE_ABCC1_SRP301382	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.37536
Golgi lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
MCF7_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140625
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22431
SAS acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
U178	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05836
BLUE1	DepMap CRISPR Gene Dependency	1.0	2.68847
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69932
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUDT16L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61048
carbohydrate derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.317805
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237847
MCF7_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0496377
PL21	CCLE Cell Line Gene CNV Profiles	1.0	1.86963
Perturb_8650_KD_GATA4_SRP287180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.121942
MCF7_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231605
MCF7_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177952
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	1.45654
abnormal genital system morphology	GWASdb SNP-Phenotype Associations	1.0	0.189608
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07882
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41799
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.989375
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_17943_KO_Stag1_SRP044099	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.44805
YY1	ENCODE Transcription Factor Targets	1.0	null
Trimetrexate_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0465636
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17309
TFAP2C-20629094-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Sarcoma_SARC_TCGA-HS-A5NA-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MPS VII - Sly syndrome	Reactome Pathways 2014	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03682
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18122
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUJ4-0926-SM-4BOPA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24695
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
anomaly of the upper limb diaphyses	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0368561
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EOMES-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Radotinib_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00935099
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49885
sleep disorder	GWASdb SNP-Disease Associations	1.0	0.471205
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-PHOX2B-fromNode_PHOX2B	Rummagene Transcription Factor Associations 2026	1.0	null
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
MCF7_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182455
H3K27me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36898
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.4
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPM-1826-SM-2YUNF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975551
Panobinostat_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141276
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33537
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	98.8913
Metapathway biotransformation(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06298
KDM4A	ENCODE Transcription Factor Targets	1.0	null
isthmus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09758
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151243
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21459
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR3C1	ChEA Transcription Factor Targets	1.0	null
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33481
(R)-Verapamil (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0465862
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195874
calvarial osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18781
hsa-miR-4323	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
MCF7_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214242
MCF7_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132226
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-N-BE(2) cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65257
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00384
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-181a	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
p-selectin	GAD Gene-Disease Associations	1.0	null
SDC2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180923
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17556
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
sulfur compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259885
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0565785
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019064
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283021
SKNDZ	DepMap CRISPR Gene Dependency	1.0	2.02474
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
arteriosclerotic cardiovascular disease	GWASdb SNP-Disease Associations	1.0	0.451391
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846217
Gallbladder Diseases	dbGAP Gene-Trait Associations	1.0	1.17462
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BV-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Generalized epilepsy with febrile seizures plus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
PPP1R1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99543
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25661
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76873
PMC7481169-277_2020_4194_MOESM7_ESM.xlsx-RUNX1_R174L-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Resveratrol_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0370065
hsa-miR-3692	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
Muscularis mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.821
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30659
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00991415
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72476
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
prostate cancer	GWASdb SNP-Disease Associations	1.0	0.55372
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.386
hsa-miR-4656	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
NCIH2122	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.20935
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5787
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49792
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
muscle tissue disease	GWASdb SNP-Disease Associations	1.0	0.230474
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0555611
hsa-miR-922	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211574
Ventral posterolateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20087
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2332
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
placenta	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.18461
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.32673
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_NM-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20765
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4540	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Medroxyprogesterone acetate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0474703
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302797
abnormality of the humerus	GWASdb SNP-Phenotype Associations	1.0	0.824663
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Defective PAPSS2 causes SEMD-PA	Reactome Pathways 2014	1.0	null
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209636
GTEX-PLZ4-1326-SM-2S1O7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63198
HDAC1	ENCODE Transcription Factor Targets	1.0	null
SARS-CoV MA15_Day2-PFU-10^5_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.41371
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.935501
GSE202434,GSE202438_7_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17904
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12384
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02138
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.892039
GTEX-OHPM-0226-SM-3LK61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09624
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SDC1	Pathway Commons Protein-Protein Interactions	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125995
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5ML-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49731
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29738
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.699793
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.82074
Perturb_13678_KD_DHX9_SRP018815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.9843
MCF7_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0307406
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
M07E	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69181
hsa-miR-4521	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22406
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71151
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.21402
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45769
hsa-miR-3119	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
SUZ12_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAKI2	CCLE Cell Line Gene Expression Profiles	1.0	1.67027
abnormality of the genital system	GWASdb SNP-Phenotype Associations	1.0	0.169653
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10189
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.84482
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.658
abnormality of the liver	GWASdb SNP-Phenotype Associations	1.0	0.26025
MCF7_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152593
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850737
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267386
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35646
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182016
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MV411	DepMap CRISPR Gene Dependency	1.0	3.37778
cleft lip	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.693098
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.98885
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01699
layer 4 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02679
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5U8-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_FEM1B_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Retrosplenial area, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.75822
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.613492
immune system disease	GWASdb SNP-Disease Associations	1.0	0.137931
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834083
EM2	DepMap CRISPR Gene Dependency	1.0	3.82937
Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.24874
PMC8755441-mmc3.xlsx-IRF7-Up-SUZ12_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836969
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
Retrosplenial area, ventral part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04046
HS-GAG biosynthesis	Reactome Pathways 2024	1.0	null
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7317
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290874
Ebolavirus(ZEBOV)_3day_Liver_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.69594
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22864
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
Nucleus reuniens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90822
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67883
hypothalamus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10317
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
NUP205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57783
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03342
hsa-miR-4268	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
HCC1500	CCLE Cell Line Gene Expression Profiles	1.0	1.53452
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6754
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14372
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196805
PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Down-regulated-Supplementary_Table_S2_Down-reguated_genes_expression_in_MESP1_negative_cells_MESP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-2826-SM-4BOQ2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835279
Learning Disorders	CTD Gene-Disease Associations	1.0	1.40595
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76873
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36169
HLE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46108
EFO27	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.46696
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.138535
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the male genitalia	GWASdb SNP-Phenotype Associations	1.0	0.315969
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.811001
Capivasertib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.033584
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55726
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
UROS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29075
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.68316
lung carcinoma	GWASdb SNP-Disease Associations	1.0	0.381186
HOXB4_induction_GDS3036_138_mouse_ES cell-derived embryoid bodies (EBs)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.23025
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.52461
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5985
K562	Achilles Cell Line Gene Essentiality Profiles	1.0	1.74638
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
ZRANB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15469
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.246946
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.048131
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87513
abnormality of the vertebral column	GWASdb SNP-Phenotype Associations	1.0	0.237723
CHD2	ENCODE Transcription Factor Targets	1.0	null
Metabolism of carbohydrates	Reactome Pathways 2014	1.0	null
ZFP322A-24550733-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
breast carcinoma	GWASdb SNP-Phenotype Associations	1.0	0.472241
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15487
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.752484
Perturb_12717_KD_KMT2C_SRP110043	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
heparan sulfate sulfotransferase activity	GO Molecular Function Annotations 2015	1.0	null
cerebellar nuclei of CbV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43477
Neoplasms	CTD Gene-Disease Associations	1.0	1.26825
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.116388
Acute Myeloid Leukemia_LAML_TCGA-AB-2965-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
MPS II - Hunter syndrome	Reactome Pathways 2014	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LAMA84	Achilles Cell Line Gene Essentiality Profiles	1.0	1.13864
anomaly of the limb diaphyses	GWASdb SNP-Phenotype Associations	1.0	0.824663
lymph node disease	GWASdb SNP-Disease Associations	1.0	0.798096
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55283
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124154
HCST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08141
Diammonium Glycyrrhizinate_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0252884
H3K27me3_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLI1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33857
MCF7_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171467
hsa-miR-3133	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.99987
Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960139
oral cleft	GWASdb SNP-Phenotype Associations	1.0	0.605341
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275291
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Phosphoadenosine phosphosulfate	HMDB Metabolites of Enzymes	1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11139868-41598_2024_63346_MOESM5_ESM.xlsx-Table_S6-Supplementary_Table_S6_Down-regulated_TCF7L1_target_genes_with_promoter_TCF7L1_binding_TCF7L1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1563	CCLE Cell Line Gene CNV Profiles	1.0	1.79808
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPC2	Pathway Commons Protein-Protein Interactions	1.0	null
L1236	CCLE Cell Line Gene Expression Profiles	1.0	3.40768
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.266678
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53522
MCF7_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216161
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077062
Defective SLC26A2 causes chondrodysplasias	Reactome Pathways 2014	1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4714-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185721
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NIHOVCAR3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05961
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040224
AR-22383394-PROSTATE-CANCER-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44369
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cv-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193984
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312595
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4703-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
hsa-miR-23c	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290534
AGRN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62443
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37964
GTEX-OIZH-0726-SM-3NB1I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05714
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5369
CD63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00702
GTEX-XYKS-2626-SM-4BRUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31685
Adenosine 3',5'-diphosphate	HMDB Metabolites of Enzymes	1.0	null
physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.164786
Muscle myosin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.672
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.03308
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWCY-0826-SM-48TCR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24048
Sarcoma_SARC_TCGA-X6-A7WB-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08794
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0464603
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131161_5_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-550a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92433
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190181
diffuse mesangial sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
hsa-miR-3609	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
substance dependence	GWASdb SNP-Disease Associations	1.0	0.219744
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80K-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4683	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.128
triglyceride	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042656
abnormality of finger	GWASdb SNP-Phenotype Associations	1.0	0.824663
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.86381
Almonertinib (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0233109
lymphatic system disease	GWASdb SNP-Disease Associations	1.0	0.45441
PMC10794186-41598_2024_51947_MOESM16_ESM.xlsx-Supplementary_Table_14_Shared-Supplementary_Table_14_Shared_genes_between_Gong_et_al_clusters_and_SOX9-AS1_regulated_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017118
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02567
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04407
hsa-miR-3185	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3664-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
Perturb_14701_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.37539
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QF-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244505
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013042
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869463
Prostate adenocarcinoma_PRAD_TCGA-M7-A725-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.67957
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CBX2	ENCODE Transcription Factor Targets	1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Myoclonic epilepsy of Lafora	Reactome Pathways 2014	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MMAC-SF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0712456
GTEX-R55G-0926-SM-48FDN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973048
SKMEL30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47455
hsa-miR-1251	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
Field CA1, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11261
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51685
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0304939
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.310783
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.924971
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41799
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08218
NCI-H508	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4772-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19915
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.967401
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MORF4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43084
NCIH1836	CCLE Cell Line Gene CNV Profiles	1.0	1.47747
BPH1	DepMap CRISPR Gene Dependency	1.0	3.13402
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A463-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28515
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927807
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.294413
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2705
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38488
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-7	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
retinal disease	GWASdb SNP-Disease Associations	1.0	0.421889
glaucoma	GWASdb SNP-Disease Associations	1.0	0.691778
MCF7_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261179
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8056
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.891857
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07175
abnormal cortical bone morphology	GWASdb SNP-Phenotype Associations	1.0	0.824663
Entorhinal area, medial part, dorsal zone, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30635
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219643
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0695
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0575
H3K27me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ralimetinib dimesylate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0452015
Lobules IV-V, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21851
hsa-miR-489	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
obesity	GeneRIF Biological Term Annotations	1.0	null
Perturb_6636_KO_SATB1_ERP024525	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.4828
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20437
abnormality of the prostate	GWASdb SNP-Phenotype Associations	1.0	0.472241
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35881
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0453372
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.34203
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0297768
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11332
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0110918
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0543717
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47282
MCF7_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216501
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.299936
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6042
Lung adenocarcinoma_LUAD_TCGA-49-6742-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58105
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28896
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318661
MCF7_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237569
hsa-miR-4531	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23309
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199697
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXA1-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE238018_1_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199427
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC11110418-12864_2024_10412_MOESM1_ESM.xlsx-S_Table_2-Supplementary_Table_2_Detailes_of_the_instrumental_variables_of_plasma_proteins_used_in_discovery_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38025
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0467604
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
dexamethasone_mus musculus_gpl5137_gse10900	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4291	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.841
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04062
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-513a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.658
MMRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43804
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845285
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11309
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.891751
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.907249
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.25368
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cabozantinib (S-malate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183266
SAMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07594
IZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846716
hsa-miR-515-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KS1	CCLE Cell Line Gene Expression Profiles	1.0	1.39318
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062803
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.02167
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.4797
abnormality of upper limb bone	GWASdb SNP-Phenotype Associations	1.0	0.824663
Carbidopa (monohydrate)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0386698
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7617
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.91646
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322667
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3913
KP-N-RT-BM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of digit	GWASdb SNP-Phenotype Associations	1.0	0.824663
Kidney Chromophobe_KICH_TCGA-KO-8411-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neoplasm of the breast	GWASdb SNP-Phenotype Associations	1.0	0.472241
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34968
CCFSTTG1	CCLE Cell Line Gene Expression Profiles	1.0	2.27728
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025042
hsa-miR-3662	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21896
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Hemorrhage	CTD Gene-Disease Associations	1.0	1.06698
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916168
abnormality of granulocytes	GWASdb SNP-Phenotype Associations	1.0	0.297943
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054457
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48535
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28482
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.373869
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.393
HT1376	DepMap CRISPR Gene Dependency	1.0	5.72842
Metabolism of carbohydrates	Reactome Pathways 2024	1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Epothilone A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191034
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850946
PMC9692021-Table_4.xlsx-Table_S4-Table_S4_405_DEGs_of_RA_synovial_tissues_between_NFIL3-high_and_NFIL3-low_group_NFIL3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.394491
MCF7_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025949
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52082
Busulfan_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0115944
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127715
Glycosaminoglycan metabolism	Reactome Pathways 2024	1.0	null
MCF7_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256247
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.959255
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.295739
JK1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.34654
Slit-Robo signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.079528
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19228
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.902387
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075584
Perturb_7741_KD_NOLC1_SRP316009	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18479
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894322
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965137
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-BNC2-gene_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208224
MCF7_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178591
GBX2-23144817-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1287	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905274
GSE232261,GSE232263_0_v_1_usf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0421457
EZH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21987
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE147366_3_v_5_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lactate (calcium)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00794413
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92122
syndrome	GWASdb SNP-Disease Associations	1.0	0.357293
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.79875
Sarcoma_SARC_TCGA-DX-A6Z2-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42848
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0312138
MCF7_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0392603
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853337
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181105
HCC1419	CCLE Cell Line Gene Expression Profiles	1.0	1.80847
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09614
lung disease	GWASdb SNP-Disease Associations	1.0	0.555273
Fastigial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53739
cho-k1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67821
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6309
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09834
MPS IIIB - Sanfilippo syndrome B	Reactome Pathways 2014	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4053969-gb-2013-14-7-r81-S3.XLSX-YB1-targeted-genes-gene_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WEY5-1026-SM-4LMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27977
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.298011
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.177246
GTEX-V955-1326-SM-4JBHR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838676
cancer	GWASdb SNP-Disease Associations	1.0	0.563237
cerebellar white matter	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47622
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03975
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5125
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.50472
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.873606
abnormal diaphysis morphology	GWASdb SNP-Phenotype Associations	1.0	0.824663
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867475
leukopenia	GWASdb SNP-Phenotype Associations	1.0	0.619164
EP300	ENCODE Transcription Factor Targets	1.0	null
MCF7_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254102
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7941
hsa-miR-3675-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4115
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219689
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.244213
MCF7_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0401057
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06147
MCF7_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146541
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205729
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168448
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Table_S4C_Downregulated_genes_in_lesions_and_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_the_mammary_duct_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.663421
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066459
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2308
PMC12582692-medi-104-e45093-s001.xlsx-Table_S1-Table_S1_Genetic_instruments_of_plasma_proteins_for_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37516
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP2C-20629094-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1466
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276213
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170121
TCF4	ChEA Transcription Factor Targets	1.0	null
GSE197117_0_v_1_kdm6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259432
KO52	CCLE Cell Line Gene CNV Profiles	1.0	1.45802
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
neutropenia	GWASdb SNP-Phenotype Associations	1.0	0.619164
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03812
MCF7_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272854
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Meloxicam_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205712
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
DMRTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76792
GTEX-S4Q7-0226-SM-4AD5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24844
MCF7_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0580716
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.177246
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.828658
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.477278
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
olaparib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0338488
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
r4 part of pontine raphe cell population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00532
GSE214382,GSE214383_0_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LB-100_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244221
PMC7204122-4623107.f1.docx-7-GZF1_GZF1	Rummagene Transcription Factor Associations 2026	1.0	null
COV644	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.46722
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	0.932288
Medial habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17458
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Celecoxib_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00706198
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetal Lung	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.27227
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.099659
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-13q34_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
glaucoma	GWASdb SNP-Phenotype Associations	1.0	0.29474
hsa-miR-514b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.006367
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cognitive impairment	GWASdb SNP-Phenotype Associations	1.0	0.601097
MCF7_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023701
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91041
Perturb_4722_KO_Smarcc1/Smarcc2_SRP124677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.27051
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0296738
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1963	CCLE Cell Line Gene CNV Profiles	1.0	1.49326
TMTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25329
Perturb_4014_KD_TCF21_SRP262152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	2.39829
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32097
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19994
PMC11485038-384_2024_4744_MOESM1_ESM.xlsx-Sheet3-Supplementary_Table3_Unique_leader_cis-pQTLs_for_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
lung cancer	GWASdb SNP-Disease Associations	1.0	0.520253
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832665
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73161
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.859817
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6317
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.317234
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0398717
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06365
abnormality of the skull base	GWASdb SNP-Phenotype Associations	1.0	0.824663
GSE135030_3_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_11574_KO_miR375_SRP273175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.19772
NCIH1650	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68392
KMBC2	CCLE Cell Line Gene Expression Profiles	1.0	1.84252
MCF7_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131337
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.96885
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.16967
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
Zygotene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.042939
coronary artery disease	GWASdb SNP-Phenotype Associations	1.0	0.694067
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54284
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14232
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08192
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.276158
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49569
RUSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62171
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141865
Perturb_8612_KO_miR1792_SRP076942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.05622
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47282
TM6SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03627
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_3_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17276
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.09471
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.61094
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040196
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81369
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273917
Entorhinal area, medial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60821
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0385064
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MPS IIIC - Sanfilippo syndrome C	Reactome Pathways 2014	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE130401_4_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34674
MCF7_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165665
colchicine_homo sapiens_gpl3386_gds1753	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49933
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07099
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197183
abnormality of facial skeleton	GWASdb SNP-Phenotype Associations	1.0	0.399819
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139455_2_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03618
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05857
hsa-miR-4297	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48264
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933201
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chondrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.699116
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7231-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160758
brain disease	GWASdb SNP-Disease Associations	1.0	0.54368
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUZ12-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26156
SEC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09324
MCF7_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0436548
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63669
IZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846059
PMC11364504-41388_2024_3115_MOESM2_ESM.pdf-205-CREBZF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141014
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7213-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902514
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.12746
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76502
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57742
hsa-miR-766	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
cell type cancer	GWASdb SNP-Disease Associations	1.0	0.236688
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A5KF-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6057
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0257684
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.107756
CTCF_DEPLETION_GDS3294_97_mouse_germinal vesicle (GV) oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.258493
MCF7_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219264
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.22664
REST	ChEA Transcription Factor Targets	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.395
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28121
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93081
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13456
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_6_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42426
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02947
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
layer 3 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05008
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.959972
GTEX-WEY5-1126-SM-4LMIE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969441
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32469
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
F36P	Achilles Cell Line Gene Essentiality Profiles	1.0	1.52283
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81086
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05498
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7777191-pnas.2007991117.sd03.xlsx-E2F1_Q6-PROBE_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2811
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231802
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062312
PSN1	CCLE Cell Line Gene Expression Profiles	1.0	1.49964
PMC8881251-18_2022_4183_MOESM3_ESM.xlsx-ERM_vs_P4-DEGs_ERM_versus_P4_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.351631
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09365
GTEX-XUZC-0226-SM-4BOO7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966682
Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25322
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135349
COL16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06778
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172912
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
palate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.600881
HCC33	CCLE Cell Line Gene CNV Profiles	1.0	1.66471
MCF7_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.053613
H3K27me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0419232
abnormality of the upper arm	GWASdb SNP-Phenotype Associations	1.0	0.462996
clavicular sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
GSE218727_2_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hesperidin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0117148
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18922
SYO1	DepMap CRISPR Gene Dependency	1.0	2.20985
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0413311
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234607
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.90091
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943641
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069427
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0288278
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116525
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869748
Bergenin_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0157375
GTEX-XUJ4-1126-SM-4BOPC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869029
ACER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09225
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Saquinavir_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.022072
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.65094
Cepharanthine_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0339132
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_5_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147912
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3552
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25218
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
MARVELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15198
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13622
E2F	MotifMap Predicted Transcription Factor Targets	1.0	null
HOXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00761
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316543
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
KLF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32199
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.50173
hsa-miR-138	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-203	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.937622
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
GPC1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269856
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0779
nucleotide-excision repair factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.679
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01113
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09194
RAJI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
DM3	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16865
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-328	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A3Y1-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YV-1626-SM-2YUNJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35099
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MPS IX - Natowicz syndrome	Reactome Pathways 2014	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17073
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06507
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the posterior segment of the eye	GWASdb SNP-Phenotype Associations	1.0	0.3707
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.11766
sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lambdoid septal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54459
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88055
layer 2 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.194
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.126
MONOMAC6	CCLE Cell Line Gene CNV Profiles	1.0	1.37062
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053564
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88822
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sclerosis of hand bone	GWASdb SNP-Phenotype Associations	1.0	0.824663
H9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE1	CCLE Cell Line Gene CNV Profiles	1.0	2.16387
ZNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06746
JARID2	ChEA Transcription Factor Targets	1.0	null
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219264
GSE192771_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.33761
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DU-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230579
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.11606
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MM1S	DepMap CRISPR Gene Dependency	1.0	2.42597
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00515
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0388973
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.216936
Inflammation	CTD Gene-Disease Associations	1.0	1.46542
Brain Lower Grade Glioma_LGG_TCGA-HT-7695-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retinal ganglion cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.489447
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93653
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932986
Diseases associated with glycosaminoglycan metabolism	Reactome Pathways 2014	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39782
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-1226-SM-48FCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19431
mantle zone of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0356
NCIH1792	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.44222
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0276151
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07431
abnormality of the mouth	GWASdb SNP-Phenotype Associations	1.0	0.148867
Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.036698
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64745
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831942
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7XC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63509
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
Omeprazole (sodium)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197827
RD	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0765
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
agranulocytosis	GWASdb SNP-Disease Associations	1.0	0.718849
H3255	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LJI308_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0140282
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.24305
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0293208
Glycosaminoglycan biosynthesis - heparan sulfate / heparin	KEGG Pathways 2026	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.152116
Ropivacaine (hydrochloride monohydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0317272
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197114
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.004
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	Reactome Pathways 2014	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
MCF7_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258234
SIRT4_KO_GDS4823_505_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Age at first sexual intercourse	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12234
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4676
PSMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52981
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70299
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
muscular disease	GWASdb SNP-Disease Associations	1.0	0.208705
GTEX-XBED-2426-SM-4AT4O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994437
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047551
RPS6KB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13279
abnormality of the retina	GWASdb SNP-Phenotype Associations	1.0	0.342228
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.244213
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025558
amygdalohippocampal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01209
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.40531
hsa-miR-656	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03513
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958881
MCF7_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021477
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
demyelinating disease	GWASdb SNP-Disease Associations	1.0	0.93638
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53693
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2237
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT4_KO_GDS4823_30_mouse_hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.951736
Lobules IV-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28987
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mental depression	GWASdb SNP-Disease Associations	1.0	0.823951
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5916
Obesity	HuGE Navigator Gene-Phenotype Associations	1.0	null
Systolic Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073382
HCC202	CCLE Cell Line Gene Expression Profiles	1.0	1.53855
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978768
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
heparan sulfate sulfotransferase activity	GO Molecular Function Annotations 2023	1.0	null
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
RAB22A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44885
Binimetinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0281562
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.88832
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormality of the humeral diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.824663
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04315
SJSA-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vitamin K4_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00421451
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7614477-EMS174138-supplement-Supplementary_Material.docx-9-HIVEP1_HIVEP1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36042
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148579
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27103
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24025
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.996635
abnormality of the thorax	GWASdb SNP-Phenotype Associations	1.0	0.824663
AGPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52159
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0434474
NCIH2052	DepMap CRISPR Gene Dependency	1.0	5.13478
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4966
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.04352
FGFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23243
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04861
Perturb_9219_KO_Mecp2_SRP056141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ZNF776	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.65992
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.11676
Niclosamide (olamine)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0243369
TC71	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48032
transferase activity	GO Molecular Function Annotations 2015	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEG01	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99274
MCF7_Decitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025178
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127322
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09682
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mouse - Motor Cortex - Subclass - Layer 5-6 glutamatergic neuron, near-projecting	HuBMAP Azimuth Cell Type Annotations	1.0	null
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LYL1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-3691-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24721
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SNOS-1726-SM-32PLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56621
H3K4me1_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16612
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41894
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.107999
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8698
MCF7_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0317365
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13735
Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33721
Dapagliflozin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205461
LK2	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Perturb_5768_KO_Sip1/Nkx21_SRP010804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.6253
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.5724
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.92197
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.907754
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54708
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
Retrosplenial area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95931
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843883
SF268	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51721
Ixazomib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00768399
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22975
Retrosplenial area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02302
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
depression	GWASdb SNP-Phenotype Associations	1.0	0.719063
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1233
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888817
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
EZH2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0408991
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23615
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03839
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18141
OCIMY5	DepMap CRISPR Gene Dependency	1.0	3.59245
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01565
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tomivosertib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0141566
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100217_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the forearm	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167175
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25501
prostate neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.472241
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83438
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.473486
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00969539
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.371187
abnormality of the clavicle	GWASdb SNP-Phenotype Associations	1.0	0.824663
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chondrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.1452
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.295739
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08151
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129698
MCF7_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217423
hsa-miR-3128	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5430-01A-02R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.865883
Retrosplenial area, ventral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44557
Prostate adenocarcinoma_PRAD_TCGA-HC-7232-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26571
abnormality of the rib cage	GWASdb SNP-Phenotype Associations	1.0	0.824663
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154826
respiratory system cancer	GWASdb SNP-Disease Associations	1.0	0.389412
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197807
MCF7_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018606
Albuminuria	dbGAP Gene-Trait Associations	1.0	0.101028
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870299
presubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03403
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0314
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0401759
18535662-TableS2d	GeneSigDB Published Gene Signatures	1.0	null
MCF7_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186378
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021391
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13381
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in caudal cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01863
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8961
GSE149760_3_v_1_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16149
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETC-206_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0520542
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43084
RXF393	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08296
CDC42EP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84164
UACC812	CCLE Cell Line Gene CNV Profiles	1.0	2.9416
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12944
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03767
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98702
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34011
abnormal axial skeleton morphology	GWASdb SNP-Phenotype Associations	1.0	0.379516
PRDM14-20953172-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of radial diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.824663
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063853
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.208075
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40197
abnormality of the costochondral junction	GWASdb SNP-Phenotype Associations	1.0	0.824663
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Gemcitabine_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0304832
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.917178
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965137
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17391
lung	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
SLC22A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03887
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HS852T	CCLE Cell Line Gene Expression Profiles	1.0	1.71847
hsa-miR-3185	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01054
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46869
AR	ChEA Transcription Factor Targets	1.0	null
GPC4	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64996
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23549
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4533	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MCF7_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111485
Homoharringtonine_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0323743
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_12_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHK1_KD_GSE54268_665_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Creativity	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06676
Kidney	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02795
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WSU-NHL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LOVO	DepMap CRISPR Gene Dependency	1.0	2.84169
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149827
LTBR_INHIBITION - 27 Day_GDS2004_736_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
abnormal renal morphology	GWASdb SNP-Phenotype Associations	1.0	0.419829
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860243
Major depressive disorder (MTAG)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121054
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
ChIP_RNF2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73485
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF382	CCLE Cell Line Gene Expression Profiles	-1.0	-2.60744
OE33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53503
PMC10993587-12967_2024_4919_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_Genetic_instruments_of_plasma_proteins_for_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118205
Amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UMUC16	DepMap CRISPR Gene Dependency	1.0	11.3249
Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041041
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04407
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28049
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10987
MCF7_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144325
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0309296
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131161_3_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the cerebral white matter	GWASdb SNP-Phenotype Associations	1.0	0.463519
DM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47839
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.970581
Metapathway biotransformation(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24777
hsa-miR-518a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.006367
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.866449
ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Cinacalcet_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106974
metabolic process	GO Biological Process Annotations 2015	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24145
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-13q34_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54362
mania	GWASdb SNP-Phenotype Associations	1.0	0.442285
RNF2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262868
GPATCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54547
Metapathway biotransformation Phase I and II	WikiPathways Pathways 2024	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2818-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14277
Diabetic retinopathy	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
MCF7_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0426581
PMC11518751-Table1.xlsx-Table_S1_IV_for_MR-exposure_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-23b	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
OCI-M1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.74667
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867657
VMRCRCW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43108
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325745
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12107
PPARD	ChEA Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05808
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165689
MONOMAC6	Achilles Cell Line Gene Essentiality Profiles	1.0	1.7222
HCC33	CCLE Cell Line Gene Expression Profiles	1.0	2.04587
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52345
GSE174701_5_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PLCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18119
Prostate adenocarcinoma_PRAD_TCGA-VP-A87J-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4419b	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4299	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
Goserelin (acetate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0249956
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47647
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0674
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07161
MCF7_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152994
GTEX-S4P3-1826-SM-3K2AL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861528
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E0-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nicotine dependence	GWASdb SNP-Disease Associations	1.0	0.578411
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AHR	ChEA Transcription Factor Targets	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72649
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20316
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05295
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04887
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02016
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856306
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0363692
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NMB	DepMap CRISPR Gene Dependency	1.0	15.5831
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66253
JARID2-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Hepatitis B	DisGeNET Gene-Disease Associations	1.0	null
Retrosplenial area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02675
JUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71134
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947884
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TCF7L2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12457
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081321
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.93438
hsa-miR-4504	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lobules IV-V, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43018
diaphyseal sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
H3K27me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28896
SF172	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.1096
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.186816
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.07216
chr13_95997869_A_C_b38	GTEx eQTL 2025	1.0	7.43729
MCF7_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300656
MCF7_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0375593
P31FUJ	CCLE Cell Line Gene CNV Profiles	1.0	1.88567
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.03046
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_11_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073135
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.190772
hsa-miR-181b	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
PMC10657376-41467_2023_43213_MOESM7_ESM.xlsx-DaNs_EBF1-Unnamed_6_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW403	DepMap CRISPR Gene Dependency	1.0	2.40266
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19466
GSE186647,GSE217288_1_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
breast cancer	GWASdb SNP-Disease Associations	1.0	0.55372
abnormality of the gallbladder	GWASdb SNP-Phenotype Associations	1.0	0.757153
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135849
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Total cholesterol levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
VCAP	DepMap CRISPR Gene Dependency	1.0	2.26438
GSE192771_2_v_1_mt1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199974
UBE2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19471
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1515
CEBPA-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01998
EED	ChEA Transcription Factor Targets	1.0	null
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207265
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.174188
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0404736
MCF7_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0417347
PHF8	ENCODE Transcription Factor Targets	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143217
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04417
GSE180525,GSE180528_2_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00487
MT-ND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14033
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.687608
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.768244
metaphyseal sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
Retrosplenial area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27552
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04241
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.920916
Defective CHST14 causes EDS, musculocontractural type	Reactome Pathways 2014	1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9646482-mmc13.xlsx-ST13B_AA-specific-regions-Unnamed_13_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17439
Flutamide_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0150015
NCIH522	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53503
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06053
SBI-0640756_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0305067
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.928068
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861057
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2789
CORL311	CCLE Cell Line Gene Expression Profiles	1.0	1.62388
myopathy	GWASdb SNP-Disease Associations	1.0	0.769887
PMC5828413__F2	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heparan sulfate/heparin (HS-GAG) metabolism	Reactome Pathways 2024	1.0	null
GTEX-SIU7-1326-SM-4BRWW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965336
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MPS IV - Morquio syndrome A	Reactome Pathways 2014	1.0	null
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17955
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1964
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH3122	DepMap CRISPR Gene Dependency	1.0	3.82925
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4QS-1826-SM-2S1NI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43715
SUZ12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35674
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235457
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08193
PMC6930440-jcav11p0520s3.xlsx-MI_vs_FG-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222468
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45695
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20807
MCF7_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161334
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22906
MCF7_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175462
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.357
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the abdomen	GWASdb SNP-Phenotype Associations	1.0	0.13643
HMEC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0345157
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57083
DMRT1	ChEA Transcription Factor Targets	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-282-DZIP1_DZIP1	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10584
abnormality of the lower urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.399819
Avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hsa-miR-4768-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60284
SKNDZ	CCLE Cell Line Gene Expression Profiles	1.0	1.47345
GPC3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.876939
Prostate adenocarcinoma_PRAD_TCGA-HC-7742-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47622
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31844
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Alpelisib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0092822
Perturb_4935_KD_TP53_SRP067400	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161482
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117668
Perturb_4193_KO_Mbnl1_SRP057123	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.24691
hsa-miR-539	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.5323
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09783
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0812269
NUGC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
clinical modifier	GWASdb SNP-Phenotype Associations	1.0	0.367568
internal granular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47333
MCF7_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148331
ACP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16404
MCF7_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322082
CYB561A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38461
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206638
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044279
external segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35371
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
extracellular region	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KMS26	DepMap CRISPR Gene Dependency	1.0	4.58672
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61218
Rapamycin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0185237
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254895
abnormality of phalanx of finger	GWASdb SNP-Phenotype Associations	1.0	0.824663
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6494-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121295
MCF7_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161286
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-2426-SM-4AT55	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10339
MCF7_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195402
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162764
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34968
hsa-miR-3161	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45396
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3999
MCF7_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0415051
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129502
trastuzumab_homo sapiens_gpl570_gse15043	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0663
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260891
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153585
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857904
chr13_96004878_A_G_b38	GTEx eQTL 2025	1.0	5.08015
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178301
abnormal gallbladder physiology	GWASdb SNP-Phenotype Associations	1.0	1.68057
MCF7_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148355
sclerosis of skull base	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0403111
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076496
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07693
LYL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Levobupivacaine (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0285507
TBP	ENCODE Transcription Factor Targets	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_2_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12702048-ijmsv23p0133s1.xlsx-Table_S1-Table_S1_Instrumental_variables_of_plasma_proteins_used_in_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	3.08621
HIRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00584
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95081
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59559
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27034
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	4.41804
Prostate adenocarcinoma_PRAD_TCGA-HC-7736-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IMR-32 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
hsa-miR-636	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
MCF7_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147569
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase	InterPro Predicted Protein Domain Annotations	1.0	null
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.89329
Copula pyramidis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10201
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01304
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCI-LY-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14468
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.265519
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.847906
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60334
Cognitive function	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
NCIH1623	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49552
SMAD3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Tranilast_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222996
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136675
diaphyseal sclerosis of the upper limbs	GWASdb SNP-Phenotype Associations	1.0	0.824663
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057828
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07642
putamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17855
RPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51228
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843934
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
male reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.339425
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Roxadustat_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0232503
Weight Gain	CTD Gene-Disease Associations	1.0	1.25432
GSE174418,GSE174421_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IP-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8452624-41467_2021_25709_MOESM12_ESM.xlsx-ST12-Unnamed_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
EFE184	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93827
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.30493
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPC6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8779_Mut_SMARCB1_SRP223162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.28086
GSE234514,GSE234516_2_v_0_mitf_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156923_2_v_1_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21195
MCF7_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026716
Perturb_9163_KD_Shp2_SRP351122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.21091
MCF7_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018641
Human - Fetal Development - L2 - Stomach-Neuroendocrine cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979222
MCF7_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151607
PMC5828413__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197019
eye and adnexa disease	GWASdb SNP-Disease Associations	1.0	0.30078
ARNT-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25923
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12321
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56838
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54561
RBM38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06135
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24086
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
LEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1639
MCF7_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.037041
SUZ12-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01444
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52461
SK-GT-2	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
urethral sphincter sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
neoplasm of the lung	GWASdb SNP-Phenotype Associations	1.0	0.642942
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58361
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14484
abnormal internal genitalia	GWASdb SNP-Phenotype Associations	1.0	0.134338
MYC	ENCODE Transcription Factor Targets	1.0	null
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	2.37133
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.933661
Memory Disorders	CTD Gene-Disease Associations	1.0	1.17728
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1549
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6Y9-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-24	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1737
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukopenia	GWASdb SNP-Disease Associations	1.0	0.377824
RAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53516
GTEX-QCQG-0126-SM-48U27	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956534
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09703
Retrosplenial area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18157
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19507
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03862
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3447
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.966278
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fulvestrant_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00255424
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
hsa-miR-664	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.82444
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0483061
HIV-1_LAI_12Hour-UV_treatment_None_GSE56484	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.56475
hsa-miR-224	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JJN3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20817
Necrosis	CTD Gene-Disease Associations	1.0	1.54306
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2712-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01466
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Adenoma_Colon_GSE4183	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.37705
MCF7_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0292468
sclerosis of finger phalanx	GWASdb SNP-Phenotype Associations	1.0	0.824663
Adrenocortical carcinoma_ACC_TCGA-OR-A5K3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Human - Kidney - L2 - Vascular Smooth Muscle / Pericyte	HuBMAP Azimuth Cell Type Annotations	1.0	null
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6512-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
GTEX-TMMY-0626-SM-33HBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59885
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51805
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04158
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89509
SDC3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2659-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.6679
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14426
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07861
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0368549
Prostate-hillock-club cell of prostate epithelium	Tabula Sapiens Gene-Cell Associations	1.0	1.10318
MISP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62493
gallbladder diseases	GAD Gene-Disease Associations	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	0.834891
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02195
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48019
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
abnormality of the nephron	GWASdb SNP-Phenotype Associations	1.0	0.462996
NCIH2009	CCLE Cell Line Gene CNV Profiles	1.0	1.49046
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.179059
abnormality of the breast	GWASdb SNP-Phenotype Associations	1.0	0.356312
GTEX-S95S-1626-SM-2XCDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933394
NCIH446	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84288
EW-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-1.07378
MCF7_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012622
transferase activity, transferring sulfur-containing groups	GO Molecular Function Annotations 2015	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.831433
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.877412
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230517
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43826
abnormality of the uvea	GWASdb SNP-Phenotype Associations	1.0	0.289341
RNF2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0425163
GTEX-WOFL-0626-SM-3MJG3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950845
DCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05631
MCF7_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154625
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.177897
Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Caudatenucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0048
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66964
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.089052
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7232
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CL-40	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927807
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.359089
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200239
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.363941
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-513c	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175439
hsa-miR-499-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11756
SNU668	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46363
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890433
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Defective B3GAT3 causes JDSSDHD	Reactome Pathways 2014	1.0	null
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52492
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.75362
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29897
layer II of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11662
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869976
SOX2	ChEA Transcription Factor Targets	1.0	null
KDM2B-26808549-CHIP-SEQ-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0426-SM-4LVM7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990471
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46032
ARNT	ChEA Transcription Factor Targets	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981283
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00017
Lymphatic edema_Skin tissue_GSE4333	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.71175
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07958
abnormal neutrophil cell number	GWASdb SNP-Phenotype Associations	1.0	0.619164
abnormality of the vertebrae	GWASdb SNP-Phenotype Associations	1.0	0.824663
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7605
Meloxicam_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00921033
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60973
Piccolo NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.65
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843748
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
cos cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233162
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14461
eye and adnexa disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
Betamethasone dipropionate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192946
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.39043
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07365
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
hsa-miR-3977	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1832
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010423
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0936
GSE81803,GSE81912_2_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.040353
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0837606
MCF7_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170639
rhombomere 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09048
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268955
hsa-miR-499a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
hsa-miR-4698	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GTEX-OHPM-0726-SM-3LK7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49947
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08923
esr1_21713035_mcf7_lof_human_gpl570_gds4061	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.97103
Sarcoma_SARC_TCGA-IF-A4AK-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239812
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.063073
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.210115
ARNT-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	0.996021
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155983
Obesity	DisGeNET Gene-Disease Associations	1.0	null
cortex of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32515
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.54368
AHR-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0462914
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye physiology	GWASdb SNP-Phenotype Associations	1.0	0.212684
Wnt signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.523
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.97844
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25666
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0726-SM-4LVM8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995179
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5359-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC4006	CCLE Cell Line Gene Expression Profiles	-1.0	-2.3085
hsa-miR-4472	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02457
STAT3	ChEA Transcription Factor Targets	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6668
LB647-SCLC	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2996
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-383	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
SUZ12-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PWN1-2026-SM-48TD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86952
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.563041
MCF7_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189597
intermediate stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08612
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
sleep disturbance	GWASdb SNP-Phenotype Associations	1.0	0.370368
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0185
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_391_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.442285
GTEX-PWN1-1826-SM-2S1PE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86863
osteosclerosis of the ulna	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158632
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.23025
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271548
CDKN2AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40793
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ETC-206_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204398
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.708
MCF7_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020059
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF829	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02773
RNF2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PSMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69837
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HSPG2	Pathway Commons Protein-Protein Interactions	1.0	null
KMS20	DepMap CRISPR Gene Dependency	1.0	3.29836
NCIH2882	DepMap CRISPR Gene Dependency	1.0	3.51262
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4995-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC3_KO_GDS4886_66_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SK-N-BE(2)C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
GSE146687_2_v_6_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SOX2-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.879066
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24586
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71897
HIPK2_knockout_171_GSE39253	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.687963
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72637
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03442
hsa-miR-3609	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
Piroxicam_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0345961
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119931
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60633
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-875-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
OVK18	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81188
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23658
GTEX-U3ZN-2026-SM-4DXUC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955377
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.217
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.05856
HDAC6	ENCODE Transcription Factor Targets	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18028
hsa-miR-3174	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chondrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
KMT2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80081
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00384
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hypersomnia	GWASdb SNP-Phenotype Associations	1.0	1.20643
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.289654
EZH2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
proteoglycan metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88541
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
18318837-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11801220-NIHMS2038999-supplement-14.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
HUH28	CCLE Cell Line Gene CNV Profiles	1.0	1.36272
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18183
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51315
Lung adenocarcinoma_LUAD_TCGA-55-8616-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0371363
SLC18A3_KD_GDS4325_618_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209823
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01242
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
globe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.297651
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11261
JHUEM7	DepMap CRISPR Gene Dependency	1.0	6.40021
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27457
squamous cell carcinoma	GWASdb SNP-Disease Associations	1.0	0.52866
GSE193993_1_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59166
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.128
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11932
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63669
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072938
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
APTO-253_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0168163
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55028
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
Pentoxifylline_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0189085
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.14455
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0237
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.191126
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200701
hsa-miR-4514	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	1.13459
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.38635
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.80008
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.076073
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33223
eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180725
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19986
OSC19	DepMap CRISPR Gene Dependency	1.0	2.22105
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21659
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MPS I - Hurler syndrome	Reactome Pathways 2014	1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133249
MCF7_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0286277
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9681
Ectorhinal area/Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38689
MCF7_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192627
Sarcoma_SARC_TCGA-JV-A5VE-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81369
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1588
A549	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0668832
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSPOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18065
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.00941
Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81477
KASUMI1	DepMap CRISPR Gene Dependency	1.0	2.76695
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07365
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869764
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4417
EZH2	ENCODE Transcription Factor Targets	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-731-ENSG00000134874_DZIP1	Rummagene Transcription Factor Associations 2026	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.893023
hsa-miR-4518	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04572
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142076
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35758
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.74584
MCF7_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153752
Human - Motor Cortex - Cross-Species Cluster - Lamp5+ GABAergic neuron_5	HuBMAP Azimuth Cell Type Annotations	1.0	null
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0558225
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.828628
H3K27me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
hsa-miR-4501	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143071
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RPS6KA3_knockout_73_GSE22137	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.69043
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04447
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14458
Medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
retinal degeneration	GWASdb SNP-Disease Associations	1.0	0.323969
Culmen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28805
H3K27me3_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
MCF7_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161479
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295627
mood disorder	GWASdb SNP-Disease Associations	1.0	0.433941
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
para-abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21294
mesangial abnormality	GWASdb SNP-Phenotype Associations	1.0	0.824663
mouth neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.450957
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01714
MNX1-26342078-MIN6-4N-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02902
P-Selectin	dbGAP Gene-Trait Associations	1.0	1.0538
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.86
Daidzin_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274909
SW403	CCLE Cell Line Gene CNV Profiles	1.0	2.03986
glycoprotein metabolic process	GO Biological Process Annotations 2015	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.7314
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05497
mRNA_GADD45A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019416
Entorhinal area, medial part, dorsal zone, layer 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04764
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17575
hsa-miR-4262	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
Colonic adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.328
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.841662
IOMMLEE	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.79002
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	2.68961
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.869763
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08484
PMC7825356-8844261.f3.docx-32-ZNF284_ZNF284	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0396453
Gefitinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00903089
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
sclerosis of foot bone	GWASdb SNP-Phenotype Associations	1.0	0.824663
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12516
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8848
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233182
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45257
MCF7_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183057
cortical sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018891
MCF7_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0475381
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.479856
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140298
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.917204
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92248
cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE164529_0_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAB3A_Mutation - D77G point mutation_GDS2482_704_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28834
heparan sulfate proteoglycan metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017074
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19717
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051572
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212346
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882958
Lung squamous cell carcinoma_LUSC_TCGA-43-7656-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92937
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2985
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sulfotransferase activity	GO Molecular Function Annotations 2015	1.0	null
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160233
hsa-miR-181d	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
hsa-miR-3929	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
Prostate adenocarcinoma_PRAD_TCGA-VN-A88N-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
echocardiography	GAD Gene-Disease Associations	1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.990679
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087651
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956266
urethral obstruction	GWASdb SNP-Phenotype Associations	1.0	0.824663
adrenal_4d	HPA Tissue Sample Gene Expression Profiles	1.0	1.15585
PMC11004296-Table_4.xlsx-Sheet2-Supplementary_Table_4_MR_results_of_circulating_proteins_to_XP_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978689
Growth cone membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
h9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09031
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6216
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4744
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4251	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09116
posteroventral (inferior) parietal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02113
hsa-miR-3160-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_1_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
GPC5	Pathway Commons Protein-Protein Interactions	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.246946
Lung adenocarcinoma_LUAD_TCGA-73-4675-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13094
cos-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.345558
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20214
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01491
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00301
Adult body size	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025489
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833436
P-loop containing nucleoside triphosphate hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42905
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.881867
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.28549
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2186
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.327591
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cysteamine (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0348335
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0458185
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20099
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33978
ENSG00000170846	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37112
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20076
ZFP322A-24550733-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
gastrointestinal system disease	GWASdb SNP-Disease Associations	1.0	0.248864
GSE125211_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Uvula (IX)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2962
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58156
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.260677
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10693
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0412444
PPAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0287
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99784
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-0226-SM-4DM6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13533
MCF7_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138931
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.044823
MCF7_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266258
hsa-miR-4768-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
MCF7_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234606
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930892
SBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
H3K9me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.84772
MAX	ENCODE Transcription Factor Targets	1.0	null
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.708
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal bone structure	GWASdb SNP-Phenotype Associations	1.0	0.54521
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927807
RMUGS	DepMap CRISPR Gene Dependency	1.0	3.33431
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chr13_96898391_C_A_b38	GTEx eQTL 2025	1.0	1.44047
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-527	TargetScan Predicted Conserved microRNA Targets	1.0	0.006367
Primary somatosensory area, mouth	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20347
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27245
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	1.61856
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16458
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232521
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
Smoking status (ever vs never smokers)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.822185
abnormality of long bone morphology	GWASdb SNP-Phenotype Associations	1.0	0.824663
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212981
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.88119
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052094
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127824
abducens motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33837
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057677
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068538
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3369932-pgen.1002751.s026.pdf-7-NCOA3_NCOA3	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal appendicular skeleton morphology	GWASdb SNP-Phenotype Associations	1.0	0.662268
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148909
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182024
Heparan sulfate/heparin (HS-GAG) metabolism	Reactome Pathways 2014	1.0	null
Baicalin_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0385396
COLO320	CCLE Cell Line Gene Expression Profiles	1.0	1.34721
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08923
TET1	ChEA Transcription Factor Targets	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.988013
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186736
REH	Achilles Cell Line Gene Essentiality Profiles	1.0	1.434
chronic	GWASdb SNP-Phenotype Associations	1.0	0.522136
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67164
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951926
Piriform-amygdalar area, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02707
LYL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NACA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49262
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08101
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03434
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.75015
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040135
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14521
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997556
MCF7_Rigosertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236774
H2AC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01312
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05575
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231837
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Choline	CTD Gene-Chemical Interactions	1.0	null
MOGGCCM	CCLE Cell Line Gene Expression Profiles	1.0	1.43462
BHT101	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6238
HS-GAG biosynthesis	Reactome Pathways 2014	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
Adrenocortical carcinoma_ACC_TCGA-OR-A5LP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.4
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35484
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967968
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861362
GTEX-V955-1026-SM-4JBHO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886099
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022662
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.309697
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57808
outer CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.995805
Adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1405
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0575551
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57161
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MGRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26252
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191639
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11878
Asthma_Epithelial Cell_GSE4302	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.57747
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896765
MCF7_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205322
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08504
MCF7_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0395098
TT2609C02	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70463
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P4QT-0226-SM-3LK68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18629
all	GWASdb SNP-Phenotype Associations	1.0	0.197213
ZNF263	ENCODE Transcription Factor Targets	1.0	null
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14547
abnormality of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	0.54521
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0489207
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.984407
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40696
H4K20me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
NTERA-2_CL_D1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_2635_KD_TRIM46_SRP323434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.87674
abnormality of the eye	GWASdb SNP-Phenotype Associations	1.0	0.264161
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14149
SK-N-AS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O7-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the globe	GWASdb SNP-Phenotype Associations	1.0	0.284082
MCF7_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0365573
generalized osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256659
KIF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28154
CBX8	ENCODE Transcription Factor Targets	1.0	null
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23706
MCF7_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224127
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76016
Panobinostat_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0207985
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84852
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275582
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23498
GTEX-P4QT-1326-SM-3NMD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02315
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25992
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072089
GSE132759_4_v_5_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72934
AHR-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831833
hsa-miR-2964a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03836
multiple sclerosis	GWASdb SNP-Disease Associations	1.0	0.93638
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.56762
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00163
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WM115	DepMap CRISPR Gene Dependency	1.0	2.23979
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.82
GTEX-P4PP-1826-SM-2S1NT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854759
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70294
GTEX-XPVG-2926-SM-4B66G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65759
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060576
hypersensitivity reaction disease	GWASdb SNP-Disease Associations	1.0	0.663947
Quinidine (15% dihydroquinidine)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0430407
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917527
G57321FI	GlyGen Glycosylated Proteins	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5807
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.870512
cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34674
dorsolateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47691
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70651
MPS VI - Maroteaux-Lamy syndrome	Reactome Pathways 2014	1.0	null
MCF7_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0299785
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
patchy sclerosis of radial diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.824663
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Mucopolysaccharidoses	Reactome Pathways 2014	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.991136
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lenalidomide (hemihydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0239822
NCI-H929 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.128
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39411
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040826
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201709
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.26607
PMC7430827-12864_2020_6933_MOESM6_ESM.xlsx-Sheet1-Additional_file_6_Table_S6_A_list_of_103_genes_containing_only_non-synonymous_SNPs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
1321N1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.55656
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06071
hsa-miR-3689d	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	1.8999
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heparan sulfate 6-O-sulfotransferase activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33414
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27637
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.957951
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
KAT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06547
Retrosplenial area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34731
NAMALWA	CCLE Cell Line Gene CNV Profiles	1.0	1.56495
GTEX-O5YW-1826-SM-2YUN2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927261
Benztropine (mesylate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0249583
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.353
GSE144500_7_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7064337-elife-51373-supp1.xlsx-SUZ12_targets_shPHF19-List_of_567_genes_marked_by_SUZ12_ChIPseq_iafter_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-1726-SM-2S1PZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09389
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.70642
ZNF322	ChEA Transcription Factor Targets	1.0	null
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43274
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056145
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2576
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lipoic acid_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0289645
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A23B-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_1_PRDM6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CA46	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.850284
orofacial cleft	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.554791
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83615
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10761
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995122
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05791
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.856829
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.948014
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0108392
MCF7_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0434138
overnutrition	GWASdb SNP-Disease Associations	1.0	0.668836
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130569
MCF7_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013716
GSE135400_2_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32539
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07958
Human - Motor Cortex - Cross-Species Cluster - Sst+ GABAergic neuron_2	HuBMAP Azimuth Cell Type Annotations	1.0	null
MCF7_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268246
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.987201
nephrosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06006
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136697
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
IRF4-20064451-CD4+T-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.070308
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855989
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VAChT_KD_GDS4325_361_mouse_Heart from C57BL/6 males	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
craniofacial osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976021
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024328
hsa-miR-3942-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of the glomerulus	GWASdb SNP-Phenotype Associations	1.0	0.462996
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2BK15ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
orbital frontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.955917
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_9701_KD_RTN4R_SRP368642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.20586
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34632
heparan sulfate proteoglycan metabolic process	GO Biological Process Annotations 2023	1.0	null
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.335233
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14394
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.78043
MXI1	ENCODE Transcription Factor Targets	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	2.312
TSPAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08453
MCF7_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205758
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4448	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
costochondral joint sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
septum (resp epith)	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0631
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.954435
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55525
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Encorafenib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00223533
heparan sulfate proteoglycan biosynthetic process	GO Biological Process Annotations 2023	1.0	null
layer 3 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34821
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66222
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65674
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.1311
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234651
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.51545
mRNA_SUZ12_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
albuminuria	GAD Gene-Disease Associations	1.0	null
NCIH2291	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43606
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atherosclerosis	GWASdb SNP-Disease Associations	1.0	0.769887
Hexylresorcinol_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0183792
Hepatitis	CTD Gene-Disease Associations	1.0	1.08584
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC9A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59097
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Achilles bursitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45756
MCF7_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105548
MCF7_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211194
MDAMB361	CCLE Cell Line Gene Expression Profiles	1.0	1.37257
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.223312
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65394
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.72508
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Smoking	DisGeNET Gene-Phenotype Associations	1.0	null
MCF7_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214481
anterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899549
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14376
MCF7_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0404608
within	GeneRIF Biological Term Annotations	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.156723
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT4_KO_GSE56321_391_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hsa-miR-1266	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
Perturb_6446_OE|KD_EGFR|TRIM24_SRP100743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MCF7_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0540593
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Minodronic acid_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0228927
GATA2	ChEA Transcription Factor Targets	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40534
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13167
mRNA_MYBL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE214382,GSE214383_5_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
supragenual nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61816
MCF7_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0336924
hsa-miR-4795-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
Prostate-club cell of prostate epithelium	Tabula Sapiens Gene-Cell Associations	1.0	2.87825
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0286748
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055206
MCF7_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027089
NPIPB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31099
gallbladder disease	GWASdb SNP-Disease Associations	1.0	1.78458
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinitis pigmentosa 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.515
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82706
Pimitespib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0343022
MCF7_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224623
r1 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19497
Prostate adenocarcinoma_PRAD_TCGA-EJ-5532-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_EED_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.04468
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31294
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197356
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RM2N-0626-SM-48FD6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04741
abnormality of the ribs	GWASdb SNP-Phenotype Associations	1.0	0.824663
INO80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00347
abnormality of the metaphyses	GWASdb SNP-Phenotype Associations	1.0	0.824663
biological_process	GO Biological Process Annotations 2015	1.0	null
MPS IIIA - Sanfilippo syndrome A	Reactome Pathways 2014	1.0	null
GTEX-S341-0426-SM-4AD5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0141
heparan sulfate proteoglycan biosynthetic process, enzymatic modification	GO Biological Process Annotations 2023	1.0	null
Benztropine (mesylate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0170876
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197693
carcinoma	GWASdb SNP-Disease Associations	1.0	0.52866
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882873
superficial stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32464
ARID5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69208
increased bone mineral density	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0445173
Exostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
Rectum adenocarcinoma_READ_TCGA-AF-6136-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858148
MCF7_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195475
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65772
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088159
MCF7_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221414
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Larotrectinib sulfate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.01554
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60918
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0367289
DMS79	CCLE Cell Line Gene CNV Profiles	1.0	1.45548
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915661
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019731
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.906386
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08865
SCRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83542
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15542
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27637
VAV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06119
hsa-miR-3130-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
abnormal leukocyte count	GWASdb SNP-Phenotype Associations	1.0	0.381508
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cdx2_20696899_caco2_lof_human_gpl570_gse22572	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.576282
abnormality of myeloid leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.198142
GTEX-XQ8I-0526-SM-4BOPS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98254
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SOCS3_KO_GDS3149_8_mouse_multiple cell types	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE221386_2_v_0_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150176
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAMOXIFEN	DGIdb Drug Targets 2026	1.0	2.30139
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36058
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152782
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
chronic fatigue syndrome	GWASdb SNP-Disease Associations	1.0	0.615118
Perturb_13713_KO_ASXL2_SRP360138	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.37646
H3K27me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0380568
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.92604
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.150562
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0396
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12105
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.633
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2963-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5510-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM28	ChEA Transcription Factor Targets	1.0	null
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08649
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14468
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12434
NRF1	JASPAR Predicted Transcription Factor Targets	1.0	null
MCF7_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161403
APOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47592
Dental caries (decayed and filled deciduous teeth)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59139
HCFC1	ENCODE Transcription Factor Targets	1.0	null
VCAP	Achilles Cell Line Gene Essentiality Profiles	1.0	1.13636
posteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04927
chondrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00152
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066412
Field CA2, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27215
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.70773
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14700_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.22149
SH10TC	DepMap CRISPR Gene Dependency	1.0	3.19277
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162239
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5929-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20427
abnormality of the skull	GWASdb SNP-Phenotype Associations	1.0	0.462996
NCI-H322M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138378
HPAFII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91816
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05995
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09116
cingulate gyrus, parietal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.934095
hsa-miR-3920	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POR_KO_GDS1678_760_mouse_Colon	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040843
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FBXO22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43207
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3648
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878368
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CCNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32349
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0336295
MCF7_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159828
EFM192A	CCLE Cell Line Gene CNV Profiles	1.0	1.7442
MCF7_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013991
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35826
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07314
Lateral posterior nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863867
nucleolus-like body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2941
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
physical disorder	GWASdb SNP-Disease Associations	1.0	0.375859
hsa-miR-203	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.30463
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177003
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18289
MCF7_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177935
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055198
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72099
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.135149
MCF7_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211562
glycan structures biosynthesis 1	KEGG Pathways	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05623
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.206248
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-218	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19736
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2A	ChEA Transcription Factor Targets	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4968
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869295
H3-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00569
E2F6	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23174
abnormality of forebrain morphology	GWASdb SNP-Phenotype Associations	1.0	0.228613
PMC6766969-PATH-249-90-s005.xlsx-S1_b-Supplementary_Table_S1_b_Top_100_upregulated_and_downregulated_genes_in_TAF15-NR4A3_vs_EWSR1-NR4A3_EMC_NR4A3	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.869876
19505326-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
MCF7_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0692614
MCF7_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132226
heparan sulfate 6-o-sulfotransferase activity	GO Molecular Function Annotations 2015	1.0	null
Ouabain (Octahydrate)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260688
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080611
Perturb_8651_KD_GLYR1_SRP287180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.81504
H3K27me3_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126997
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-SKOR2-gene_SKOR2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPJH-0726-SM-4IHJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53724
GSE178714_5_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mouse - Motor Cortex - Subclass - Layer 5 glutamatergic neuron, intratelencephalon-projecting	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
Doxycycline (monohydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190819
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05898
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052708
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08923
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01704
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38594
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
increased body weight	GWASdb SNP-Phenotype Associations	1.0	1.24751
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
Body Mass Index	DisGeNET Gene-Phenotype Associations	1.0	null
Copula pyramidis, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12542
singlenucleotide	GeneRIF Biological Term Annotations	1.0	null
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25907
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08246
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CBP-20019798-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333763
GI-LA-N cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.361
Sarcoma_SARC_TCGA-DX-A3UE-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37613
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_splenic B cell_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FGFR3_druginhibition_36_GDS5023	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.76439
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36984
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73089
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128099,GSE128159_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
RNF2-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0431803
GTEX-TKQ1-1226-SM-4GICJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87342
MCF7_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276675
heparan sulfate proteoglycan biosynthetic process, enzymatic modification	GO Biological Process Annotations 2015	1.0	null
abnormality of the radius	GWASdb SNP-Phenotype Associations	1.0	0.824663
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169216
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Defective B4GALT7 causes EDS, progeroid type	Reactome Pathways 2014	1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40414
retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.781069
mbl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
MCF7_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179075
MCF7_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0387907
JARID2-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Vandetanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168688
PMC12297505-41598_2025_11704_MOESM4_ESM.xlsx-table_s4_veen-GSE16011_AND_TCGA-GBMLGG_NOT_Human_kinases_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182916
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20427
Uterine Carcinosarcoma_UCS_TCGA-N6-A4V9-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial (fastigial) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4354
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE126127_2_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IREB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11911
HCC2157	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67185
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958552
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.035783
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054252
NCIH1563	CCLE Cell Line Gene Expression Profiles	1.0	1.75145
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59754
Neratinib (maleate)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.043063
abnormality of the cerebrum	GWASdb SNP-Phenotype Associations	1.0	0.228613
MCF7_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242124
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EH-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236495
Pravastatin (sodium)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0233218
Uvula (IX), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2192
Acute Myeloid Leukemia_LAML_TCGA-AB-2873-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-1026-SM-46MVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77113
abnormality of the biliary system	GWASdb SNP-Phenotype Associations	1.0	0.360852
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IE-A4EI-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03563
MCF7_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0468089
Metabolism	Reactome Pathways 2014	1.0	null
MCF7_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240956
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221004_1_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4491_KO_Tcf4_SRP072458	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-3908	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
HMGN3	ENCODE Transcription Factor Targets	1.0	null
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10514
retinopathy	GWASdb SNP-Phenotype Associations	1.0	1.45654
NCIH1355	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45194
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Defective CHST6 causes MCDC1	Reactome Pathways 2014	1.0	null
molecular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24374
CCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18486
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86478
ABC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63257
EED-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Obesity	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184438
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.869439
Ataluren_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0275767
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067884
MCF7_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258595
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4709-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vortioxetine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213605
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
blood vessel	GTEx Tissue Gene Expression Profiles	1.0	0.94476
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of upper limb metaphysis	GWASdb SNP-Phenotype Associations	1.0	0.824663
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06211
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSK1059615_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240493
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963252
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1088
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.769887
RS411	Achilles Cell Line Gene Essentiality Profiles	1.0	1.23911
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H0-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5013636-ncomms12601-s5.xlsx-TCF3-Groups_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-1926-SM-2TF6S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879724
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atherosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.306472
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.76562
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07557
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942713
CLDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25162
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.52191
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.08925
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19627
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8076
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03155
hsa-miR-31	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01463
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral septal nucleus, intermedio-ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02597
RC-K8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6683136-41598_2019_47363_MOESM4_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
isthmic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17897
Lung squamous cell carcinoma_LUSC_TCGA-77-8007-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.954589
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EM-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4291	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0502195
MCC26	DepMap CRISPR Gene Dependency	1.0	6.00282
Perturb_12519_KD_IL13RA2_SRP304115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Echocardiography	dbGAP Gene-Trait Associations	1.0	1.09431
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.31133
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.08442
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHP212	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47883
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92772
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49794
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
termporal pattern	GWASdb SNP-Phenotype Associations	1.0	0.522136
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888702
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03131
Carbidopa (monohydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.022613
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.494
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.72809
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34083
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061829
EED-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.47995
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124582
hsa-miR-485-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
MCF7_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0383687
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885429
SARS-CoV MA15_Day4-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.22609
RMC-6236_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0301392
MCF7_Ki16425_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181392
layer 5 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16571
RAD21	ENCODE Transcription Factor Targets	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SW948	CCLE Cell Line Gene CNV Profiles	1.0	1.70968
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87063
PMC10679662-mmc3.xlsx-NC-D5-ZEB2-Mutant-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCPAP	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63997
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.22557
CBX8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	5.24872
obesity	GWASdb SNP-Phenotype Associations	1.0	1.24751
MCF7_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130318
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.16125
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PSDG-0326-SM-48TCP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839356
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150097
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chondrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.882
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09581
SUZ12	ENCODE Transcription Factor Targets	1.0	null
Perturb_12503_KD_ESR1_ERP130561	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.98504
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Altretamine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0231981
sclerosis of humeral diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.824663
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0056
hsa-miR-548ah	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.937683
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053926
TFAP2C	ChEA Transcription Factor Targets	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QXCU-0326-SM-2TC63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20098
hsa-miR-4311	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Methylprednisolone succinate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0265987
chr13_95940252_T_C_b38	GTEx eQTL 2025	1.0	1.34628
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180525,GSE180528_1_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0410803
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.300856
PACADD119	DepMap CRISPR Gene Dependency	1.0	4.70347
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.847683
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06199
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179737
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trametinib (DMSO_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0318567
CL11	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74605
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.32221
Nafamostat (mesylate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0533259
heparan sulfate sulfotransferase activity	GO Molecular Function Annotations 2025	1.0	null
MCF7_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210912
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8A-MLX_3T3_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40766
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0641762
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.25868
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.106479
MCF7_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177377
MCF7_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0358681
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044377
MDAMB435S	DepMap CRISPR Gene Dependency	1.0	4.05334
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027399
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03723
humeral sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.908767
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.28024
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40109
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.90101
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.035481
WSU-DLCL2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47T-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.878135
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.876511
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44991
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844789
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.89828
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41779
embryonic stem cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.750818
chondrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.195129
D425	DepMap CRISPR Gene Dependency	1.0	2.72996
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018505
metaanalysis	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47Y-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWOO-2426-SM-2S1OV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.823984
non-small cell lung carcinoma	GWASdb SNP-Disease Associations	1.0	0.743993
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
CTNNB1	ChEA Transcription Factor Targets	1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.937172
SUZ12	ChEA Transcription Factor Targets	1.0	null
patchy osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253858
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70933
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MPS IV - Morquio syndrome B	Reactome Pathways 2014	1.0	null
MCF7_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160913
Entorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06628
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.884844
salivary gland	GTEx Tissue Gene Expression Profiles	-1.0	-1.02555
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Baicalin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152124
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.198685
Sulfotransferase	InterPro Predicted Protein Domain Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAMD4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72841
Omodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	1.0	2.33718
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-516b	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139797
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11583
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC3_KO_GDS4886_29_mouse_heart - 6 week old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285902
obesity	GWASdb SNP-Disease Associations	1.0	1.42467
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88175
MDAMB175VII	CCLE Cell Line Gene Expression Profiles	1.0	1.63003
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902777
abnormality of the abdominal organs	GWASdb SNP-Phenotype Associations	1.0	0.153395
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of limbs	GWASdb SNP-Phenotype Associations	1.0	0.406495
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40717
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125971
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19426
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021413
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14376
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42006
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860059
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24369
abnormality of the coronary arteries	GWASdb SNP-Phenotype Associations	1.0	0.306472
Tranilast_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00584522
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027886
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055744
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63052
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168886
EZH2	ChEA Transcription Factor Targets	1.0	null
orofacial cleft	GWASdb SNP-Disease Associations	1.0	0.704237
ZNF317	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17533
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ChIP_JARID2_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Glycogen storage diseases	Reactome Pathways 2014	1.0	null
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249162
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-WK-A8XS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861057
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q8-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 2 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22842
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22671
H3K27me3_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61132
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15562
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39377
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.27333
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.380842
MCF7_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016005
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04719
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06298
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0613863
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.492307
diabetic retinopathy	GWASdb SNP-Disease Associations	1.0	1.59609
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.837731
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2662
Diabetic Retinopathy	dbGAP Gene-Trait Associations	1.0	0.965948
mouth disease	GWASdb SNP-Disease Associations	1.0	0.52866
SMARCA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28937
layer 4 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58852
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.965977
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_7_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
Refractive error	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.822185
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30904
Methionine	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.953775
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.846
MCF7_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013644
CORL47	DepMap CRISPR Gene Dependency	1.0	7.25011
GSE239844_7_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.23922
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERA-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6137
MCF7_Crizotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254881
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
golgi apparatus	LOCATE Curated Protein Localization Annotations	1.0	null
SOX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07842
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-1026-SM-4AD5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01236
RNF2	ENCODE Transcription Factor Targets	1.0	null
Enamel organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02412
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860243
L-Thyroxine (sodium salt pentahydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240171
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.407127
SACM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15189
GTEX-P4QS-0226-SM-3NB1U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974695
MCF7_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135048
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891409
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Rucaparib (phosphate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0136953
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.52461
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174645
retinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060332
PMC11799605-jomes-34-1-65-supple.pdf-11-KLF16_KLF16	Rummagene Transcription Factor Associations 2026	1.0	null
lymphadenitis	GWASdb SNP-Disease Associations	1.0	0.798096
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.82695
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	0.299936
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZS-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lonafarnib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0120461
hsa-miR-4427	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872908
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.535562
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136939
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10203
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
VILL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3517
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67463
Clopidogrel_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00405157
Vermal regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28358
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07141
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0957
abnormal eye morphology	GWASdb SNP-Phenotype Associations	1.0	0.284082
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08923
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0315266
patchy changes of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152888
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91961
SUZ12-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HUO9	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135645
ChIP_SUZ12_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137917
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 5 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26946
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCCIT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0427724
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93867
hsa-miR-2052	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
H3K27me3_CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149296
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06944
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61186
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957602
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.935074
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.03276
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0430555
GSE221742,GSE221743_1_v_2_sipa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
urethral stenosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
SLC46A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16368
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RT4	CCLE Cell Line Gene Expression Profiles	1.0	1.44987
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197625
Vemurafenib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183825
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary bladder	HPA Tissue Gene Expression Profiles	1.0	0.943418
GTF2IRD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02658
ATP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41444
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-635	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
Carcass	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2542
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
acquired metabolic disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.52461
C11orf68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54657
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14915
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-1826-SM-2YUNC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862434
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.01776
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142369
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14174
Sunitinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146018
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41988
GBX2-23144817-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015913
OTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0739
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01334
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888676
Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH508	CCLE Cell Line Gene CNV Profiles	1.0	1.7761
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35475
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194839
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860243
Obesity	GWAS Catalog SNP-Phenotype Associations	1.0	0.434785
MCF7_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0345195
cellular_component	GO Cellular Component Annotations 2015	1.0	null
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123879
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
OVISE	Achilles Cell Line Gene Essentiality Profiles	1.0	1.3535
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTF2	ChEA Transcription Factor Targets	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83438
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SF172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35093
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.658
PRKACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77584
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040314
heparan sulfate biosynthesis	KEGG Pathways	1.0	null
HS888T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74261
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0391027
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.559
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45791
hsa-miR-4324	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.128
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116871
hsa-miR-4447	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Eye-lacrimal gland functional unit cell	Tabula Sapiens Gene-Cell Associations	1.0	0.147368
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03947
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25496
MCF7_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0392595
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23498
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03126
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88777
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IE-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25621
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18028
JIMT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Defective EXT2 causes exostoses 2	Reactome Pathways 2014	1.0	null
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GAL3ST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62664
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
prostate	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
H3K27me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4478	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51619
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the ulna	GWASdb SNP-Phenotype Associations	1.0	0.824663
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221004_3_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0463628
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8175-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216692
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0433143
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4741-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115121
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.9351
Belzutifan_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0149137
musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.159302
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278168
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
narcolepsy	GWASdb SNP-Disease Associations	1.0	1.38087
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23383
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70C-01A-21R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05148
vertebral body sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.824663
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77141
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
heparan sulfate 6-sulfotransferase activity	GO Molecular Function Annotations 2025	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CYCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3531
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07058
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18844
L-Eflornithine (monohydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0344997
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14588
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09606
Perturb_7742_KD_NOLC1_SRP316009	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Primary visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5417
carcass	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.430695
MCF7_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189536
abnormal external genitalia	GWASdb SNP-Phenotype Associations	1.0	0.260456
endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486326
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31781
TE-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.09431
GSE173810_4_v_6_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CALML6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55796
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50691
RNF2-27304074-CHIP-SEQ-NSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.862483
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0393235
MCF7_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145013
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53714
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846526
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38534
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Large intestine adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_3D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18018
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0463
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9983
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015649
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.995723
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927807
Fundus of striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10101
Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1961
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Canagliflozin (hemihydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244184
DDRGK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0382
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3351
SCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35648
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912756
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09632
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212761
Glycosaminoglycan synthesis in fibroblasts	WikiPathways Pathways 2024	1.0	null
GSE129648,GSE129650_2_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ropivacaine (hydrochloride monohydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0196443
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2748
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53495
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0758
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3168	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Human - Kidney - L3 - Vascular Smooth Muscle / Pericyte	HuBMAP Azimuth Cell Type Annotations	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Dimethyl fumarate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0213011
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of forearm bone	GWASdb SNP-Phenotype Associations	1.0	0.824663
MCF7_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0380535
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12749580-42003_2025_9274_MOESM5_ESM.xls-Supplementary_Data_2A-Supplementary_Table2A_Full_results_of_the_proteome-wide_MR_in_deCODE_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0385222
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE211128_2_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197707
Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07754
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.183088
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X5EB-1426-SM-46MVW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49732
MCF7_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240472
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168306
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18064
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SKBR3	DepMap CRISPR Gene Dependency	1.0	2.78294
abnormality of the urethra	GWASdb SNP-Phenotype Associations	1.0	0.399819
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248109
Perturb_366_KD_ARID1A_SRP198293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.47104
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10097
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283829
MCF7_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0477719
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023331
neutropenia	GWASdb SNP-Disease Associations	1.0	0.718849
abnormality of the choroid	GWASdb SNP-Phenotype Associations	1.0	0.35429
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84884
layer 2 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67463
Volasertib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295768
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Reactome Pathways 2014	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57196
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0858
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_DPPA5A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907672
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.50763
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40418
thoracic cancer	GWASdb SNP-Disease Associations	1.0	0.410282
kawasaki disease	GWASdb SNP-Disease Associations	1.0	0.798096
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Histaminergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158901
kidney disease	GWASdb SNP-Disease Associations	1.0	1.29628
Pexidartinib (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0100656
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158805
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06749
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.82983
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11589140-41416_2024_2881_MOESM1_ESM.pdf-350-HOXD11_HOXD11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.629497
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.880142
abnormality of limb bone	GWASdb SNP-Phenotype Associations	1.0	0.539165
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14215
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11406
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164945
Lung squamous cell carcinoma_LUSC_TCGA-63-5131-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUP153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6888
abnormality of the cerebral subcortex	GWASdb SNP-Phenotype Associations	1.0	0.354404
hsa-miR-512-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880525
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
YMB1	CCLE Cell Line Gene Expression Profiles	1.0	1.41119
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8588
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of the upper limb	GWASdb SNP-Phenotype Associations	1.0	0.635311
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gallic acid (hydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0302972
PMC11801220-NIHMS2038999-supplement-14.xlsx-Exc-SKOR2-gene_SKOR2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q734-1026-SM-48U16	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0585
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32188
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895661
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197495
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.112453
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908903
Vandetanib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00559861
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835291
RNF2	ChEA Transcription Factor Targets	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978768
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74327
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23297
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04862
MCF7_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018032
GTEX-PLZ6-0626-SM-3P61B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59967
hsa-miR-548ah	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
AZD-7648_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271568
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-23a	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4692	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112116
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lobule II, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03132
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.59858
Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALU6	CCLE Cell Line Gene Expression Profiles	1.0	1.97562
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_2662_KD_CBX2_SRP363588	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Glycosaminoglycan metabolism	Reactome Pathways 2014	1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.934418
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0424895
NEFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49624
MCF7_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139466
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ornidazole_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0088907
abnormality of the fundus	GWASdb SNP-Phenotype Associations	1.0	0.3707
prostate cancer	GWASdb SNP-Phenotype Associations	1.0	0.472241
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RHJT	DepMap CRISPR Gene Dependency	1.0	2.21574
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128757
CALU6	CCLE Cell Line Gene CNV Profiles	1.0	2.52913
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29505
hsa-miR-1207-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
retinal vascular disease	GWASdb SNP-Disease Associations	1.0	1.00275
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03038
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61306
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Enamel epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44921
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18154
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205318
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRL-0726-SM-3NM9A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897281
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
COLO205	CCLE Cell Line Gene CNV Profiles	1.0	1.72756
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
D-247MG	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.39516
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164507
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09131
EFM19	DepMap CRISPR Gene Dependency	1.0	6.06275
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diabetic retinopathy 	GWAS Catalog SNP-Phenotype Associations	1.0	0.612268
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02892
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33475
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258673
NCIH2052	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33158
Perturb_7755_KD_NOLC1_SRP316009	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.301
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.708
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19612
ganglion cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.433374
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73225
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
arteriosclerosis	GWASdb SNP-Disease Associations	1.0	0.384706
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051554
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsalrootganglion	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.91279
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23094
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6339-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243056
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225013
hsa-miR-3913-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Tirabrutinib_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0143592
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191488
SPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04586
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.496
MCF7_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0357781
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.755713
BT483	CCLE Cell Line Gene Expression Profiles	1.0	2.13327
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARID1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31239
increased density of long bones	GWASdb SNP-Phenotype Associations	1.0	0.824663
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063027
hsa-miR-873	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
primary open angle glaucoma	GWASdb SNP-Phenotype Associations	1.0	0.593421
hsa-miR-889	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.33613
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-BNC2-gene_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
eye disease	GWASdb SNP-Disease Associations	1.0	0.30078
Pitavastatin (Calcium)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0185535
SOCS3_KO_GDS3149_297_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00012
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139362
hsa-miR-4277	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5473
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CSNK1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52118
MCF7_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0354225
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PLB985	Achilles Cell Line Gene Essentiality Profiles	1.0	1.12064
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.958207
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.75568
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.42489
IST-MES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OSRC2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59121
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4X-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16149
Primary somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02841
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041465
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	ChEA Transcription Factor Targets	1.0	null
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123231
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
Daidzin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0437054
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
retrosplenial cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02679
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9642
MCF7_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0312486
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIRT4_KO_GDS4823_22_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCIH889	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69772
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08648
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FZD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43583
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17369
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.87042
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17566
hsa-miR-4446-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Menadione_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0121072
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01133
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_overexpression_UP-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0393025
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109444
cho cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.173396
MCF7_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146708
sclerotic forearm bones	GWASdb SNP-Phenotype Associations	1.0	0.824663
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JR-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lean Body Mass	DisGeNET Gene-Phenotype Associations	1.0	null
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019494
TFAP2A-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
globe disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.752991
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1975	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91467
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.58553
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921403
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12285
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Idarubicin (hydrochloride)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0119725
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37769
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0462471
hsa-miR-1272	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
hsa-miR-3688-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Hyperostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09041
Defective CHSY1 causes TPBS	Reactome Pathways 2014	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
Perturb_4181_KO_Foxp1_SRP107214	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.23397
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.952509
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36163
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0384593
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0426-SM-2TF4U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11843
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33496
abnormality of male internal genitalia	GWASdb SNP-Phenotype Associations	1.0	0.472241
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.128
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-181c	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016626
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08859
MCF7_AT9283_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216507
abnormality of neutrophils	GWASdb SNP-Phenotype Associations	1.0	0.381508
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null