association	dataset	threshold value	standardized value
TWIST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32192
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876762
HEMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0104
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00428
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
ECHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74593
represents	GeneRIF Biological Term Annotations	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3907
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60054
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2226
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZIK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29788
NEFL	Pathway Commons Protein-Protein Interactions	1.0	null
Neurotransmitter receptor complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77473
SSBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71114
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7247
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05452
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61858
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15719
Cocaine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.18623
UNC13B	Pathway Commons Protein-Protein Interactions	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.162
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14575
ATP2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55269
TNNC1	Pathway Commons Protein-Protein Interactions	1.0	null
candidate	GeneRIF Biological Term Annotations	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
subunits	GeneRIF Biological Term Annotations	1.0	null
CAOV4	DepMap CRISPR Gene Dependency	1.0	4.5099
H2AZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71811
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15247
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23586
EIF4E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98274
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.32398
transmitter-gated monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
Hyperekplexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
Visual Perception	HuGE Navigator Gene-Phenotype Associations	1.0	null
hsa-miR-4309	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
after	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4700-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ZNF37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23222
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3564
colon	GTEx Tissue Gene Expression Profiles	1.0	0.838444
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64922
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92579
Psychomotor Performance	HuGE Navigator Gene-Phenotype Associations	1.0	null
496100456_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35526
ICC2	DepMap CRISPR Gene Dependency	1.0	2.20555
RTL8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12712
DXO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66661
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.0108
ZNF595	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98876
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.272953
EFM19	CCLE Cell Line Gene Expression Profiles	1.0	1.95665
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7296
PYGM	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1449
scale	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.78938
hsa-miR-378d	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7184
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.66454
DDX60L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02813
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54063
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23788
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35939
NCI-H211	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.977
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.51793
spectrum	GeneRIF Biological Term Annotations	1.0	null
anterograde trans-synaptic signaling	GO Biological Process Annotations 2023	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30295
TLCD3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93464
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58507
H3K27me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CAMK2D	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF841	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87216
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36254
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DLG4	Pathway Commons Protein-Protein Interactions	1.0	null
Ion channel transport	Reactome Pathways 2014	1.0	null
ZDHHC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62019
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08489
CALD1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A57M-01A-51R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DBF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52203
CAL33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66808
Barrett's esophagus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
NCIH520	CCLE Cell Line Gene CNV Profiles	1.0	1.97774
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904448
sleep apnea, obstructive	GAD Gene-Disease Associations	1.0	null
HCC1143	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49176
fusiform gyrus, left, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04109
serotonin-activated cation-selective channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.193
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7652-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
JHH5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59829
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
SEC24C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15747
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8848
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TIGD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18936
MZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37816
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UPCISCC152	DepMap CRISPR Gene Dependency	1.0	3.11531
PI4KA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26115
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.09566
ATF7IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03589
SUDHL4	DepMap CRISPR Gene Dependency	1.0	2.1358
transporter activity	GO Molecular Function Annotations 2015	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59483
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081232
NCIH1395	CCLE Cell Line Gene Expression Profiles	1.0	1.98505
Kidney Chromophobe_KICH_TCGA-KN-8436-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fourth ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.557
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A730-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOR4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69423
EFNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81989
Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
Depressive Disorder, Major	HuGE Navigator Gene-Phenotype Associations	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26359
Cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Lung adenocarcinoma_LUAD_TCGA-50-5931-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.683358
RB1CC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86846
TNNT1	Pathway Commons Protein-Protein Interactions	1.0	null
Pregnancy Complications	HuGE Navigator Gene-Phenotype Associations	1.0	null
myenteric	GeneRIF Biological Term Annotations	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9601
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.994669
htr3a	GeneRIF Biological Term Annotations	1.0	null
RERFLCSQ1	DepMap CRISPR Gene Dependency	1.0	5.06964
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98157
HCC70	DepMap CRISPR Gene Dependency	1.0	6.23827
MON	DepMap CRISPR Gene Dependency	1.0	2.02201
Olfactory tubercle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
GRANISETRON	DGIdb Drug Targets 2026	1.0	0.311365
EM2	DepMap CRISPR Gene Dependency	1.0	2.5844
RCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44917
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.40298
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Nausea	DisGeNET Gene-Phenotype Associations	1.0	null
irritable bowel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.70434
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14647
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5414
FOXD4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11486
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
CD164L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04168
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
RASGRF1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
MYL1	Pathway Commons Protein-Protein Interactions	1.0	null
SUM229PE	DepMap CRISPR Gene Dependency	1.0	2.22702
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914707
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059503
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUW-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G6PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87404
MAML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20531
FGFR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1536
H4C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57907
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.221
ZNF491	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11643
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.602
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904448
CAL120	CCLE Cell Line Gene Expression Profiles	-1.0	-2.71507
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25895
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAMOSETRON HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.622729
Neuronal System	Reactome Pathways 2024	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A4BH-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.0883
PECAPJ34CLONEC12	CCLE Cell Line Gene Expression Profiles	-1.0	-2.55383
NSUN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60705
A549	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34583
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997752
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53593
Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.936552
neurotransmitter receptor complex	GO Cellular Component Annotations 2025	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A9DB-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
CDC14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63896
SETD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75208
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6591
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45R-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vagus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.554
VPS4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02408
BTBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08804
Circular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
CXADR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77458
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
QPCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41321
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00478
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM179B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98841
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05134
DCAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58576
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13286
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07325
NANOGP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52743
FOXD4L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.30813
TE441T	CCLE Cell Line Gene CNV Profiles	-1.0	-2.54808
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A2OS-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43605
ZNF548	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24361
CAMK2B	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
icSARS CoV_0Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.83106
TCCSUP	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52472
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.962037
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4819
Serotonergic synapse	KEGG Pathways 2026	1.0	null
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAPSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0682
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.0688
MYH3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3154	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
DERL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30316
PRDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04936
PRKCA	Pathway Commons Protein-Protein Interactions	1.0	null
LN464	DepMap CRISPR Gene Dependency	1.0	2.06109
SMG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50819
Iron uptake and transport(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
ZNF292	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28047
outer CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.921578
HOXB7-26014856-BT474-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06318
hsa-miR-4667-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ETNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33914
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34366
RH30	DepMap CRISPR Gene Dependency	1.0	3.31986
GLS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90483
OXCT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67987
serotonin-activated cation-selective channel complex	GO Cellular Component Annotations 2023	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905905
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2845
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6419
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
interleukin-9 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.35
cation channel complex	GO Cellular Component Annotations 2025	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84838
Serous carcinoma_Fallopian tube_GSE10971	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.73802
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.965402
OCUB-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DROSHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90776
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEC251	DepMap CRISPR Gene Dependency	1.0	8.30586
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.88046
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.79465
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.61703
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.87574
ITGA1	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17197
receptor activity	GO Molecular Function Annotations 2015	1.0	null
ZNF808	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05247
EME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54334
cellular_component	GO Cellular Component Annotations 2015	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861371
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
DEXFENFLURAMINE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.183156
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13821
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3193
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A729-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
OVCA433	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.327
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22317
KMS34	CCLE Cell Line Gene Expression Profiles	1.0	1.46755
TPM4	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JQ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.850054
TE5	CCLE Cell Line Gene CNV Profiles	1.0	1.34767
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05107
Schizophrenic Psychology	HuGE Navigator Gene-Phenotype Associations	1.0	null
HNF4A_KD_GDS4798_550_human_HepG2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PPP5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29339
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930241
HES4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66291
NFATC3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-422a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Alexithymia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	1.93171
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2301
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07569
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.05578
Esophageal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
CAMK2A	Pathway Commons Protein-Protein Interactions	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
membrane part	GO Cellular Component Annotations 2015	1.0	null
autism	GeneRIF Biological Term Annotations	1.0	null
PRXL2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5807
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09588
NU-DUL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.23271
ZNF200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56968
ZNF844	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56213
SNAP25	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
breast neoplasms; nausea; vomiting	GAD Gene-Disease Associations	1.0	null
VCL	Pathway Commons Protein-Protein Interactions	1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.46809
OCUG1	DepMap CRISPR Gene Dependency	1.0	5.07192
ligand-gated monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
HOXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5436
PRRC2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43409
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
RASGRP1	Pathway Commons Protein-Protein Interactions	1.0	null
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76759
RAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21296
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863281
Raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.19
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
TAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22409
TPM3	Pathway Commons Protein-Protein Interactions	1.0	null
Plasma membrane signaling receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.158
Gastrointestinal system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACTN3	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29567
planum polare, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26962
RNASE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59858
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ARPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95741
OAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75812
ZNF24_01_353	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6534
serotonin receptor activity	GO Molecular Function Annotations 2023	1.0	null
DYNLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49745
SAMHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9993
SPATA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70325
RASGRF2	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-RA-A741-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41458
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34159
serve	GeneRIF Biological Term Annotations	1.0	null
hek-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.452198
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70851
TSPAN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56498
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03489
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
NKTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3035
DOV13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73497
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3288
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GCH1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.573
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.57241
Sarcoma_SARC_TCGA-IW-A3M6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6599263-13073_2019_654_MOESM2_ESM.xlsx-CAR1_tsv-gene_name_NR1I3	Rummagene Transcription Factor Associations 2026	1.0	null
WWC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67985
ZNF202	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47465
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23695
SORBS3	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.996237
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3068
A-VN-1203-2004(H5N1)_Day4-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.59429
THAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73337
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.193915
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11772
496100467_FWM_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.46842
NUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.38349
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.56677
SNU182	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9131
DCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31563
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061776
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5284
HP1BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33954
PMC4172779-13048_2014_87_MOESM1_ESM.pdf-142-ZNF383_ZNF383	Rummagene Transcription Factor Associations 2026	1.0	null
Major depressive disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.297291
MAPKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37815
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54787
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997752
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.37193
hsa-miR-3198	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
KCNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92667
SNU668	CCLE Cell Line Gene Expression Profiles	1.0	1.53684
U2OS	CCLE Cell Line Gene Expression Profiles	-1.0	-2.39224
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
Plasma membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Smooth endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645
ZIMELDINE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.183156
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833829
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02501
Sleep Apnea, Obstructive	HuGE Navigator Gene-Phenotype Associations	1.0	null
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
NCI-H2126	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CLOTHIAPINE	DGIdb Drug Targets 2026	1.0	0.345961
transverse gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.757
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879573
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5004
AZI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3671
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8114
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eating disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.8503
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26584
Neuroactive ligand signaling	KEGG Pathways 2026	1.0	null
Esophageal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
single-organism transport	GO Biological Process Annotations 2015	1.0	null
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16268
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.896458
ZKSCAN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52683
Subpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.948
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31986
PECAPJ41CLONED2	CCLE Cell Line Gene Expression Profiles	1.0	1.689
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.67042
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2973
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62177
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-2.34586
nausea; pregnancy complications	GAD Gene-Disease Associations	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.910995
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LS-1034	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83291
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36405
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.949251
STARD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32506
Mammary myoepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
g-protein coupled amine receptor activity	GO Molecular Function Annotations 2015	1.0	null
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
serotonin-gated monoatomic cation-selective channel activity	GO Molecular Function Annotations 2023	1.0	null
NEMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9128
hsa-miR-4685-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PMC9365857-41598_2022_17887_MOESM1_ESM.docx-1-IKZF4_IKZF4	Rummagene Transcription Factor Associations 2026	1.0	null
breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.222479
HS172T	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
496100652_PCx_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.00916
undergoing	GeneRIF Biological Term Annotations	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
Heroin dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
RIMKLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70275
SLC2A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97691
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2717
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.414
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824112
Transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.278
496100386_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.7799
CEP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61051
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41603
hsa-miR-617	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
hsa-miR-378i	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
KASUMI2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96212
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3611
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13142
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6264
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20115
ZNF319	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17244
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
external segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.903059
remained	GeneRIF Biological Term Annotations	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5282
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2969
CITED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57055
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1489
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12169
ZNF829	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42624
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76766
MCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19022
HHEX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27972
PMC4390530-NIHMS667786-supplement-1.xlsx-Sheet1-Supplementary_Table_2_Genes_closest_to_AR_induced_ASH2L_peaks_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_7_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3057
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833829
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	1.0	3.26209
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860833
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863281
PL4	DepMap CRISPR Gene Dependency	1.0	2.12631
MOB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44572
DGKQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57589
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.845246
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834485
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7044-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29092
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28512
Esophageal carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	1.0	7.12438
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.74066
Myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.079
Fibromyalgia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055466
GMPPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74294
ETAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51151
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0735
RTN4RL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36192
Breast Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.3887
EZH2	ENCODE Transcription Factor Targets	1.0	null
HCC202	DepMap CRISPR Gene Dependency	1.0	2.32361
METTL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41421
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861371
Mitochondrial inner membrane assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.253
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051777
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04965
Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1
PPP2R5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06543
SU8686	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56111
MAFK	ENCODE Transcription Factor Targets	1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5376
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99249
PARP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41659
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.972967
ERBB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2685
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7631
PKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31307
Nucleus solitarius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICR6	CCLE Cell Line Gene Expression Profiles	1.0	1.49443
NCIH929	CCLE Cell Line Gene Expression Profiles	1.0	1.78775
GTPBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21053
neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GO Molecular Function Annotations 2025	1.0	null
NAA16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73448
UMUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.48215
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861371
NYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54851
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colon	HPA Tissue Gene Expression Profiles	1.0	1.15011
Neurotransmitter receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.692
PPP3R1	Pathway Commons Protein-Protein Interactions	1.0	null
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05164
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058721
htr3b	GeneRIF Biological Term Annotations	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49327
SLC35B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02703
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
FACINICLINE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.518941
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GRIN2A	Pathway Commons Protein-Protein Interactions	1.0	null
YAMATO	DepMap CRISPR Gene Dependency	1.0	6.08691
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.14797
TPM1	Pathway Commons Protein-Protein Interactions	1.0	null
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6862
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19785
A427	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GOLT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59797
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.09982
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863281
PPFIA2	Pathway Commons Protein-Protein Interactions	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.34303
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44406
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCM1	DepMap CRISPR Gene Dependency	1.0	5.45338
ZNF430	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50475
PRDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31743
MYL2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZBTB46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11342
hsa-miR-512-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
JAGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69426
other	GAD High Level Gene-Disease Associations	1.0	0.293278
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65918
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06741
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46516
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.09284
METTL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44342
TNNI3	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-CoV MA15_Day4-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89035
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10526
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RMDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80291
Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.916343
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuron projection	GO Cellular Component Annotations 2025	1.0	null
NCI-H1304	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
time	GeneRIF Biological Term Annotations	1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66435
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PKN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83714
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
Barrett's esophagus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
FAM111B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8345
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
MYL3	Pathway Commons Protein-Protein Interactions	1.0	null
PPP3CB	Pathway Commons Protein-Protein Interactions	1.0	null
SNUC1	DepMap CRISPR Gene Dependency	1.0	3.1616
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.940819
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.12866
TTN	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1_01_154	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58597
ACSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99309
SEMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05634
HNF4A_KD_GSE29084_694_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
htr3d	GeneRIF Biological Term Annotations	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF563	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82976
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
SULF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89262
IOMMLEE	CCLE Cell Line Gene Expression Profiles	1.0	2.61303
SLC29A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38643
TIGAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01696
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06135
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.886891
NCIH2170	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39288
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DJ-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DCP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93483
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.828266
TPM2	Pathway Commons Protein-Protein Interactions	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61655
PRKCD	Pathway Commons Protein-Protein Interactions	1.0	null
STX1A	Pathway Commons Protein-Protein Interactions	1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0874
TP53_01_10	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.56241
AMISULPRIDE	DGIdb Drug Targets 2026	1.0	0.119756
IQCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87015
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE180	CCLE Cell Line Gene CNV Profiles	1.0	1.7966
SLC9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23935
FZD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77944
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Vomiting	HuGE Navigator Gene-Phenotype Associations	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0206
H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885869
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7237
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27859
pregnancyassociated	GeneRIF Biological Term Annotations	1.0	null
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8448
CASZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70972
FAM131B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38967
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81352
schizophrenia	GAD Gene-Disease Associations	1.0	null
Enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.004
SMG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60408
TBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94226
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932354
LC-1-SQ	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
CAMK2G	Pathway Commons Protein-Protein Interactions	1.0	null
RENZAPRIDE	DGIdb Drug Targets 2026	1.0	0.518941
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00329
Esophageal cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.253127
PDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86605
EVSAT	DepMap CRISPR Gene Dependency	1.0	2.4611
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9755
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52175
C80	DepMap CRISPR Gene Dependency	1.0	4.27164
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0349
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.94124
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90887
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12735
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60347
ACOT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07038
Lung squamous cell carcinoma_LUSC_TCGA-77-7141-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
psych	GAD High Level Gene-Disease Associations	1.0	0.295739
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14793
PABPC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.64871
NCI-H196	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RASGRP2	Pathway Commons Protein-Protein Interactions	1.0	null
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4204
MZ in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.998102
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16847
number	GeneRIF Biological Term Annotations	1.0	null
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.33251
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997752
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18898
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49943
ATP5MC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88087
20460173-ImmPortCytokineReceptors	GeneSigDB Published Gene Signatures	1.0	null
U-698-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
duodenum	HPA Tissue Gene Expression Profiles	1.0	1.00827
PIP4P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55512
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36405
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56669
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46927
PNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28566
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.21031
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37839
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71858
ACP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74467
RBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55584
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.04601
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48784
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87171
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.726
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.62792
SNU503	CCLE Cell Line Gene CNV Profiles	1.0	1.76146
CTCF_02_185	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62803
VARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70785
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chemical synaptic transmission	GO Biological Process Annotations 2025	1.0	null
PLEKHH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15489
Apocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2006
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.943614
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
hsa-miR-378h	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228234
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34072
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1238
PRELID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08686
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30024
LMOD1	Pathway Commons Protein-Protein Interactions	1.0	null
SRI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41522
TCAP	Pathway Commons Protein-Protein Interactions	1.0	null
HSD11B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.2762
SOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99377
FLI1	ChEA Transcription Factor Targets	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CAPRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06399
CHDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68716
NCIH82	CCLE Cell Line Gene Expression Profiles	-1.0	-2.49493
serotonin receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
BORCS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49422
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58518
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14544
KYSE-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KLK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77323
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5549-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9685
RNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92939
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYL9	Pathway Commons Protein-Protein Interactions	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.8562
EHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47316
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37914
Mammary myoepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0846
RPL22L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77984
NEB	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH661	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51296
Sarcoma_SARC_TCGA-DX-AB2X-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02451
RAB9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69167
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
GGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10859
VCY1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40782
YIPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6571
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MD-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4294	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25051
BBS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84468
Neurotransmitter-gated ion-channel ligand-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
PPP3CA	Pathway Commons Protein-Protein Interactions	1.0	null
NFATC1	Pathway Commons Protein-Protein Interactions	1.0	null
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.349
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.533861
investigated	GeneRIF Biological Term Annotations	1.0	null
WBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95475
CREM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28156
CCC5	DepMap CRISPR Gene Dependency	1.0	2.0229
angle-closure glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
single-organism localization	GO Biological Process Annotations 2015	1.0	null
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANKRD28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31679
l45	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
MARK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4655
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
RRM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8246
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
MRPL40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19884
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.777
NOL4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6795
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7464
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98237
establishment of localization	GO Biological Process Annotations 2015	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35939
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2928
PHAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26234
FASTKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76406
Adenocarcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
Autistic Disorder	CTD Gene-Disease Associations	1.0	2.88009
C1orf159	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58835
excitatory extracellular ligand-gated monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05787
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1214
FBXO44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30117
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
serotonin-gated cation-selective signaling pathway	GO Biological Process Annotations 2025	1.0	null
inner CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855593
MBNL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91583
TROPISETRON	DGIdb Drug Targets 2026	1.0	0.239511
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889004
BARX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06207
BRICD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04569
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.928
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26807
SNU878	CCLE Cell Line Gene Expression Profiles	1.0	1.37169
Taste transduction	KEGG Pathways 2026	1.0	null
LMNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52991
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37448
HOXC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03952
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30024
Angle Closure Glaucoma	DisGeNET Gene-Disease Associations	1.0	null
TBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28329
LN319	DepMap CRISPR Gene Dependency	1.0	2.52905
CREB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25618
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8876
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15999
pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.480186
ZNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20543
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GGTLC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63979
SYT1	Pathway Commons Protein-Protein Interactions	1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0609
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4463
NDUFS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5249
FAM72B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71919
FBXO21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62149
LMNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25907
Gut wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222224
serotonin	GeneRIF Biological Term Annotations	1.0	null
FAM98C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96323
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.85926
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50924
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06135
COL18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27437
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
TMOD1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CH157MN	DepMap CRISPR Gene Dependency	1.0	4.98277
reproduction	GAD High Level Gene-Disease Associations	1.0	0.293278
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1478
MRNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41711
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neurotransmitter receptor complex	GO Cellular Component Annotations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78843
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2617
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5645-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PXN	Pathway Commons Protein-Protein Interactions	1.0	null
Lung-capillary aerocyte	Tabula Sapiens Gene-Cell Associations	1.0	2.25649
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910868
HS 294T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6688
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04059
KLHL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40915
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.81959
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.6194
ALDH7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01591
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49525
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.91802
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9823
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.933614
PMC8946083__F7	PFOCR Pathway Figure Associations 2024	1.0	null
DACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10298
CIDEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73519
SNU449	CCLE Cell Line Gene Expression Profiles	1.0	1.72346
GPATCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74828
BAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77792
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45361
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.9824
first	GeneRIF Biological Term Annotations	1.0	null
embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451042
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04059
Lung squamous cell carcinoma_LUSC_TCGA-98-8022-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRIN2D	Pathway Commons Protein-Protein Interactions	1.0	null
Pain disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
hsa-miR-3170	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10705
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55072
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COX6B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26079
Obsessive-Compulsive Disorder	DisGeNET Gene-Disease Associations	1.0	null
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.522405
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996718
DOLASETRON	DGIdb Drug Targets 2026	1.0	0.518941
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6403
HOXC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97333
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BGC823	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35466
HCC1897	CCLE Cell Line Gene CNV Profiles	1.0	1.6916
GPAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39925
KATOIII	CCLE Cell Line Gene Expression Profiles	1.0	1.35724
HDGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02554
VASH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57152
hsa-miR-4772-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
hsa-miR-378c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NCIH1299	CCLE Cell Line Gene Expression Profiles	1.0	2.20738
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NAMALWA	CCLE Cell Line Gene Expression Profiles	1.0	1.53232
Primary Angle-Closure Glaucoma	DisGeNET Gene-Disease Associations	1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904448
Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1682
fusiform gyrus, left, bank of the its	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.897357
risperidone	GeneRIF Biological Term Annotations	1.0	null
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9643
nausea; vomiting	GAD Gene-Disease Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	1.69104
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3014
Small_Intestine-intestinal tuft cell	Tabula Sapiens Gene-Cell Associations	1.0	0.773734
ZNF705A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56583
KYO1	CCLE Cell Line Gene Expression Profiles	1.0	1.60481
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
KIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80641
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.414
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960571
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40231
HOXC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47685
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.930496
htr3e	GeneRIF Biological Term Annotations	1.0	null
ZBTB38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83218
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.884
cell part	GO Cellular Component Annotations 2015	1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22214
Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8284
icSARA deltaORF6_60Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.0034
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04965
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7565
tested	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superior rostral gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98688
IRF1	ENCODE Transcription Factor Targets	1.0	null
COA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0397
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	1.66026
all	GWASdb SNP-Phenotype Associations	1.0	0.028127
Nausea	HuGE Navigator Gene-Phenotype Associations	1.0	null
inferior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.904858
AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48473
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
ARHGEF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90776
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
MYBPC3	Pathway Commons Protein-Protein Interactions	1.0	null
subcallosal cingulate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12346
TE-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872477
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
subunit	GeneRIF Biological Term Annotations	1.0	null
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10377
TOMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55319
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCDC88B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52977
serotonin receptor activity	GO Molecular Function Annotations 2015	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65648
NCIH510	DepMap CRISPR Gene Dependency	1.0	2.71932
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0937
icSARA deltaORF6_48Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.18263
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09779
Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
should	GeneRIF Biological Term Annotations	1.0	null
indicates	GeneRIF Biological Term Annotations	1.0	null
ZNF287	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52381
BFTC-905	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04056
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.836788
Neurotransmitter-gated ion-channel transmembrane domain	InterPro Predicted Protein Domain Annotations	1.0	null
TE159T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67475
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17027
predictive	GeneRIF Biological Term Annotations	1.0	null
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8138
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81045
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q8-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SP-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46252
Gastroesophageal reflux disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
hsa-miR-631	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Gastrointestinal endocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
superior parietal lobule, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.999156
serotonin-gated monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
NCIH23	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13937
SERPINH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70129
HIF1A_DEPLETION_GDS2760_642_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
THAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66462
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053426
EIF2AK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71722
INKA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26083
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
MARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66308
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11036
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10265
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
VAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70696
ADHD and autism ASD pathways	WikiPathways Pathways 2024	1.0	null
well	GeneRIF Biological Term Annotations	1.0	null
IVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30347
Stress Disorders, Traumatic	HuGE Navigator Gene-Phenotype Associations	1.0	null
BFTC905	DepMap CRISPR Gene Dependency	1.0	2.76449
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.8157
NKIRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79763
PRMT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05195
AKAP9	Pathway Commons Protein-Protein Interactions	1.0	null
ME1	CCLE Cell Line Gene Expression Profiles	1.0	1.46735
WERIRB1	DepMap CRISPR Gene Dependency	1.0	10.5734
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.05281
HCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62236
NCI-H1648	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	2.1437
HCFC1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14245
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56764
Sarcoma_SARC_TCGA-WK-A8XO-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70873
Attention	HuGE Navigator Gene-Phenotype Associations	1.0	null
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8751
AMIGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07751
C127I cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
hsa-miR-3661	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20375
Nicotinic acetylcholine-gated receptor, transmembrane domain	InterPro Predicted Protein Domain Annotations	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6849-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DESI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95306
SPIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71769
ZNF500	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88737
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75201
NDUFS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37688
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.27153
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5311
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7857
EPLC272H	CCLE Cell Line Gene Expression Profiles	1.0	1.46171
RAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2346
GUSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42976
RDES	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43936
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59913
htr3c	GeneRIF Biological Term Annotations	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-5898-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41496
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32493
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6588
ZNF30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42077
KCTD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07083
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15623
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94505
IFIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31526
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
Nicotine dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44525
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02171
CNGA1	Pathway Commons Protein-Protein Interactions	1.0	null
other	GeneRIF Biological Term Annotations	1.0	null
KHM1B	CCLE Cell Line Gene Expression Profiles	1.0	1.44652
ZNF417	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94846
S1PR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71692
NCIH1648	CCLE Cell Line Gene CNV Profiles	1.0	1.40703
TTC642	DepMap CRISPR Gene Dependency	1.0	5.00539
MOSAPRIDE	DGIdb Drug Targets 2026	1.0	0.518941
DDX3Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62084
DDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52068
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SH3GLB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84577
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35834
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.857822
Temporomandibular joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
KLHL25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42296
RERF-LC-SQ1	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.511
neuron projection	GO Cellular Component Annotations 2023	1.0	null
Sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
DLX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73129
TP53BP1_KD_GSE54268_670_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.058
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1049
BCL9L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66214
TDRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8689
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3094
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
TNNT3	Pathway Commons Protein-Protein Interactions	1.0	null
PRKCZ	Pathway Commons Protein-Protein Interactions	1.0	null
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.541
SLC25A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58921
DDX19B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27055
hsa-miR-4270	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3851
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
APOBEC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28111
APREPITANT	DGIdb Drug Targets 2026	1.0	1.24546
ERCC6L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68397
EIF1AY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36266
T47D	CCLE Cell Line Gene CNV Profiles	1.0	1.50142
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01307
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3237
HOPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89516
WDR83OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12282
MZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.905661
NUDUL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95493
ISTMES2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86608
variants	GeneRIF Biological Term Annotations	1.0	null
ZKSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20907
Transmission across Chemical Synapses	Reactome Pathways 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.993439
DNAJB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4087
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30016
Esophageal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
EPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20951
MYL6B	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08486
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.242
hsa-miR-3179	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.69854
AXIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64663
MYH6	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ligand-gated ion channel transport	Reactome Pathways 2014	1.0	null
STXBP1	Pathway Commons Protein-Protein Interactions	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.638859
DCXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48923
NG-108-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.162
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.35607
signal transduction	GO Biological Process Annotations 2015	1.0	null
MDS-L cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INHBE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72965
METTL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88016
H3C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14025
autism	GAD Gene-Disease Associations	1.0	null
substantia nigra, reticular part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52072
serotonin-activated cation-selective channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4077-01B-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TDRD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96176
g-protein coupled receptor activity	GO Molecular Function Annotations 2015	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12474
RASGRP4	Pathway Commons Protein-Protein Interactions	1.0	null
SFXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97555
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.71396
hsa-miR-3978	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.59638
PYGB	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
REXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.087
AHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73785
ABHD17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77244
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03826
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10682
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17968
six	GeneRIF Biological Term Annotations	1.0	null
DOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48521
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0355
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23691
RRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10328
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832257
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13328
HCC1419	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TE10	CCLE Cell Line Gene CNV Profiles	1.0	2.36211
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PLA2G4A	Pathway Commons Protein-Protein Interactions	1.0	null
GSTK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57886
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.269753
vomiting	GeneRIF Biological Term Annotations	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.57511
MROH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79293
cation channel complex	GO Cellular Component Annotations 2023	1.0	null
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31332
E2F8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97546
TMEM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14844
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1735
ZNF267	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47511
17823238-TableS5	GeneSigDB Published Gene Signatures	1.0	null
kidney	GTEx Tissue Gene Expression Profiles	-1.0	-1.08348
neurons	GeneRIF Biological Term Annotations	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8424-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935558
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
SEC11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11401
gyrus rectus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.905079
TEDATIOXETINE	DGIdb Drug Targets 2026	1.0	0.283059
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5243
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056404
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.95
HMCB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95595
Lung-capillary endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	4.61145
PMC12046329-cd-24-1509_supplementary_genesets_suppsm.xlsx-prostate_sig_genes-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45218
SNU81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48177
TNNI2	Pathway Commons Protein-Protein Interactions	1.0	null
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
HINT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80654
NFE2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44222
GALNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23769
single-organism process	GO Biological Process Annotations 2015	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20379
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996718
RAB3A	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860048
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0533
BZRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843984
MYBPC2	Pathway Commons Protein-Protein Interactions	1.0	null
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4612
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51907
NCI-H128	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875195
PTPN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45798
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Vomiting	DisGeNET Gene-Phenotype Associations	1.0	null
PMC10243915-uxad037_suppl_supplementary_table_s1a.pdf-326-ZNF714_ZNF714	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996718
TBC1D16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32665
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28794
MRPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4796
biological_process	GO Biological Process Annotations 2015	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02624
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
Amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.557
Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pathogenesis	GeneRIF Biological Term Annotations	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.462237
GPSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47739
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30331
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6861-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APUD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04965
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860048
INA6	DepMap CRISPR Gene Dependency	1.0	4.9907
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.03087
FASTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20835
MYEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94728
disorders	GeneRIF Biological Term Annotations	1.0	null
UCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27677
SKUT1	CCLE Cell Line Gene Expression Profiles	1.0	1.39189
TM-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
ZCCHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47826
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056611
autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.561004
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.876663
Area postrema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.852
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35939
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
planum polare, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.18581
ZBTB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15703
coexpressed	GeneRIF Biological Term Annotations	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
647V	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33331
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
MYH8	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8705244__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Enteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
Corpus epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09419
ZNF541	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39605
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20674
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPFIA3	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-SNU-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE160817_4_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80148
glycine-gated chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.815
ATP6V0A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52663
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.80347
moderately	GeneRIF Biological Term Annotations	1.0	null
Serotonergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.27
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6137
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.56736
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10672
LDLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43612
Neuropsychological Tests	HuGE Navigator Gene-Phenotype Associations	1.0	null
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54088
FKBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02496
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6718
VPS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54107
Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEPHS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54732
Anterior chamber depth	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.809691
BEX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21174
Type 1 diabetes mellitus_Thymic epithelial cell_GSE11	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.767
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4654
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09805
TMEM203	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2204
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39511
HOXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57349
NCI-H520	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
PIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75782
HEXIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78658
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
Caudate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
MYL4	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840181
VPS52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0079
A427	DepMap CRISPR Gene Dependency	1.0	3.6912
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
IGF2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73669
A1CF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82003
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.538604
Neurotransmitter-gated ion-channel, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44747
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
OV7	CCLE Cell Line Gene CNV Profiles	1.0	2.59542
PIK3R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86333
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
FZD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80795
RIMS1	Pathway Commons Protein-Protein Interactions	1.0	null
MZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842557
SHISA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53993
severity	GeneRIF Biological Term Annotations	1.0	null
RIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47495
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3031
Brain Lower Grade Glioma_LGG_TCGA-HT-7608-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
DCTPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79213
chr3_184055413_G_A_b38	GTEx eQTL 2025	1.0	1.45114
EFO21	CCLE Cell Line Gene CNV Profiles	1.0	1.51986
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7393
AR-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16634
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
Autism	DisGeNET Gene-Disease Associations	1.0	null
Apocrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.163
HECTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84278
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29147
BNIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3401
SSBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9576
ARCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59341
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913187
MRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67887
PIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52367
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3671
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
serotonin receptor activity	GO Molecular Function Annotations 2025	1.0	null
NFKB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03179
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24626
GATA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28351
EGR1	ENCODE Transcription Factor Targets	1.0	null
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54147
NFATC2	Pathway Commons Protein-Protein Interactions	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860048
HA1E	DepMap CRISPR Gene Dependency	1.0	2.09641
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7795
GRIN2B	Pathway Commons Protein-Protein Interactions	1.0	null
Primary angle-closure glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.874
CACUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4523
membrane	GO Cellular Component Annotations 2015	1.0	null
MYH11	Pathway Commons Protein-Protein Interactions	1.0	null
TCEAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58548
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2261
chemotherapyinduced	GeneRIF Biological Term Annotations	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.55291
SKHEP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43083
PYGL	Pathway Commons Protein-Protein Interactions	1.0	null
LRRC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38214
layer I of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10601
Basal telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
H2AZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70368
TRIM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19522
GNA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69803
Cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.414
NUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7888
transmitter-gated monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
Vestibular hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
SMIM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05504
ZGLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02258
RRAGD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86196
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colo-320 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
MYL12B	Pathway Commons Protein-Protein Interactions	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8229
FUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91017
NCI-H1755	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21909
hsa-miR-4530	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16709
NCIH1869	CCLE Cell Line Gene Expression Profiles	1.0	1.70913
GRHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63941
KPNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34635
JM1	CCLE Cell Line Gene Expression Profiles	1.0	1.9085
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
obsessive-compulsive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
ZNF554	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89233
ITGB5	Pathway Commons Protein-Protein Interactions	1.0	null
KDM4F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37813
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44525
JUND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59694
YIPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2497
KYSE270	DepMap CRISPR Gene Dependency	1.0	2.76973
PLXNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.674
PLPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89867
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64232
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.225395
Somatoform disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
Eca-109 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TXNDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41144
BV173	CCLE Cell Line Gene Expression Profiles	1.0	1.56777
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.06959
METTL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18039
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC56	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83658
ZNF503	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98105
DMD	Pathway Commons Protein-Protein Interactions	1.0	null
Esophageal adenocarcinoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
hsa-miR-378e	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.8128
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Plasma membrane signaling receptor complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
A-VN-1203-2004(H5N1)_Day4-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.91998
EOMES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51252
SMAD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31057
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9375
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226411
Esophagus adenocarcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.571
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
Ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58507
SENP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76378
KYSE-70	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35517
TT	CCLE Cell Line Gene CNV Profiles	1.0	1.42946
ZNF385B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6281
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3964
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929791
YTHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42438
significant	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DAAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87991
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4636
GRIN2C	Pathway Commons Protein-Protein Interactions	1.0	null
inner CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.848216
symptoms	GeneRIF Biological Term Annotations	1.0	null
HSPA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69775
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	2.0157
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
PPFIA4	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16634
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4093
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPFIA1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A4ZT-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3797
SEMA3F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75669
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nausea And Vomiting	DisGeNET Gene-Phenotype Associations	1.0	null
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90446
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-11A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLHL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57104
SYT5	Pathway Commons Protein-Protein Interactions	1.0	null
HCST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16578
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.773
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43131
PHTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02544
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50165
ACCMESO1	DepMap CRISPR Gene Dependency	1.0	2.23494
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7034
lung	GTEx Tissue Gene Expression Profiles	1.0	2.16236
PUSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40921
647-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBE2G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04511
Parahippocampal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
populations	GeneRIF Biological Term Annotations	1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996718
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26A-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65563
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997752
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36405
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860048
Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE-10	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
KMS20	DepMap CRISPR Gene Dependency	1.0	3.92977
SNU475	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51671
Ergoloid mesylate	DrugBank Drug Targets	1.0	null
NEFH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44261
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8257
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04059
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91346
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051904
hsa-miR-3136-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
TNNC2	Pathway Commons Protein-Protein Interactions	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059002
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.52787
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
KMT2E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96052
icSARS CoV_24Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.10521
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5005
FAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12717
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15329
TNNT2	Pathway Commons Protein-Protein Interactions	1.0	null
large	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86776
HEYA8	CCLE Cell Line Gene Expression Profiles	1.0	1.38407
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26584
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
Barrett Esophagus	DisGeNET Gene-Disease Associations	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ACTN2	Pathway Commons Protein-Protein Interactions	1.0	null
Alcohol dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
MED16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89232
HNF4alpha_DEPLETION_GDS4798_91_human_HepG2 hepatocellular carcinoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66775
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86779
hsa-miR-4689	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05134
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902638
NEK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69767
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039899
Neurotransmitter receptors and postsynaptic signal transmission	Reactome Pathways 2024	1.0	null
Vestibular sensory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
TINF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09194
PSME3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49898
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.02607
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6761-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15329
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.798867
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4002
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94999
MYBPC1	Pathway Commons Protein-Protein Interactions	1.0	null
CAL-85-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.36889
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47285
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8145
ion transport	GO Biological Process Annotations 2015	1.0	null
TOMM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61215
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
PPM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36129
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94261
NAP1L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5976
SW1783	CCLE Cell Line Gene Expression Profiles	-1.0	-2.13708
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26722
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06135
ZNF250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75837
ERRFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33874
Inhibited female orgasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inner CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.95761
IFNGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74611
Neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21545
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18898
496100414_TCx_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15741
LHX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03187
PWWP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60301
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843984
CEP170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04892
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58171
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07238
496100610_TCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.70191
ZNF582	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16346
hsa-miR-3690	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19253
SPINDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78715
Neurotransmitter-gated ion-channel	InterPro Predicted Protein Domain Annotations	1.0	null
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.994714
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051415
MKI67	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72482
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936717
Enteric nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
ABHD17C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37783
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
Psychiatric Status Rating Scales	HuGE Navigator Gene-Phenotype Associations	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.894862
SLC4A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03133
plexus	GeneRIF Biological Term Annotations	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BLTP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39812
haloperidol	GeneRIF Biological Term Annotations	1.0	null
RCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00088
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834794
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7644-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FERD3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03761
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42861
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.065775
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Circumventricular organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
TRIM36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74561
BLACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71428
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83568
FOXA1-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Motion sickness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
VAMP2	Pathway Commons Protein-Protein Interactions	1.0	null
Schizophrenia	HuGE Navigator Gene-Phenotype Associations	1.0	null
REP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55643
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.12152
TNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48036
BBC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44711
DDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66356
correction	GeneRIF Biological Term Annotations	1.0	null
ACTG2	Pathway Commons Protein-Protein Interactions	1.0	null
Cognition Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6832
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62739
NUP155	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7521
C6orf89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44367
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.223192
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55568
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15999
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87039
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9046
MOLP2	CCLE Cell Line Gene Expression Profiles	1.0	3.40796
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XRCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31217
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05134
ALX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43293
assessed	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VILL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3517
Colon sigmoideum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.029
C1GALT1C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12391
RHO	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10042887-41419_2023_5742_MOESM3_ESM.xlsx-Table_S3-Table_S3_Differently_expressed_genes_in_HOXB3_vs_HOXB3-_aPCA_HOXB3	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56171
PUMOSETRAG	DGIdb Drug Targets 2026	1.0	0.622729
ARMCX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59088
NCIH1573	DepMap CRISPR Gene Dependency	1.0	2.76741
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3424
BHLHE40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28463
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.839698
STAT6_01_50	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58542
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7043
Esophagus adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18835
Insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.871
KDM5B	ENCODE Transcription Factor Targets	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44525
SORBS1	Pathway Commons Protein-Protein Interactions	1.0	null
TVP23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00833
PRKCB	Pathway Commons Protein-Protein Interactions	1.0	null
SMAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07061
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.258064
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLDN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79478
GGCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84393
NCIH446	DepMap CRISPR Gene Dependency	1.0	7.67152
DDP-225	DGIdb Drug Targets 2026	1.0	0.518941
TP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22411
submucosal	GeneRIF Biological Term Annotations	1.0	null
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5001
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.935603
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11113
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1651
Ec	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26359
Adrenocortical carcinoma_ACC_TCGA-OR-A5JZ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Obsessive-Compulsive Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
SLC17A7	Pathway Commons Protein-Protein Interactions	1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28812
hsa-miR-378	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CNGB1	Pathway Commons Protein-Protein Interactions	1.0	null
PAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35661
KYSE70	CCLE Cell Line Gene CNV Profiles	1.0	1.8913
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84608
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
MIDEAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33774
syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.550134
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51J-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2546
LYPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63665
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.94786
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.773
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AMO1	DepMap CRISPR Gene Dependency	1.0	9.23191
Avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.581
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906637
inner CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.904304
Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular ligand-gated monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
ADM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18578
NB17	DepMap CRISPR Gene Dependency	1.0	3.1936
hsa-miR-4441	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
bodies	GeneRIF Biological Term Annotations	1.0	null
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.8256
serotonin-activated cation-selective channel complex	GO Cellular Component Annotations 2025	1.0	null
RTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60959
HDAC2	ENCODE Transcription Factor Targets	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.81924
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9048
tsA-201 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
MRPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95651
Serotonin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.494
RASA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94826
nausea	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-382	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34111
chemotherapy	GeneRIF Biological Term Annotations	1.0	null
ZNF329	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25489
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.989577
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49I-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
channel activity	GO Molecular Function Annotations 2015	1.0	null
ligand-gated monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-349-TFE3_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03749
NEIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02442
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.682
Personality disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
SGSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59247
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.05393
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
coding	GeneRIF Biological Term Annotations	1.0	null
TBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35593
SETDB1	ENCODE Transcription Factor Targets	1.0	null
intestine	GeneRIF Biological Term Annotations	1.0	null
Nausea In Pregnancy	DisGeNET Gene-Phenotype Associations	1.0	null
LAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65455
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996718
TIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54604
lung	HPA Tissue Gene Expression Profiles	1.0	2.08767
Myenteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.436
Muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.036
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A49H-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAR-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GO Molecular Function Annotations 2025	1.0	null
Autistic Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8132
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3578
TNNI1	Pathway Commons Protein-Protein Interactions	1.0	null
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57965
GRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5849
OLANZAPINE	DGIdb Drug Targets 2026	1.0	0.0915778
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1868
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16526
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SIGIRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71598
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.922461
Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27657
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.58545
Perturb_15525_OE_PIM1_SRP331248	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.46488
TIPRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78437
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95205
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845452
MRPL20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8438
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39512
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26251
Irritable bowel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.099
short insular gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1673
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
STX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34673
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.487106
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40101
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100373_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.66957
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5697
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860048
RERFLCAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5472
RBM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79558
DRAXIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67487
GSE111247_14_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ischemic colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.864204
Esophageal squamous epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00092
OCILY18	DepMap CRISPR Gene Dependency	1.0	3.04776
localization	GO Biological Process Annotations 2015	1.0	null
GLIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99486
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19736
HMGXB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66907
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.75223
ligand-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996718
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8543
anterograde trans-synaptic signaling	GO Biological Process Annotations 2025	1.0	null
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71257
biological regulation	GO Biological Process Annotations 2015	1.0	null
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SN12C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
locus	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastric fundus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.717
DES	Pathway Commons Protein-Protein Interactions	1.0	null
SLC27A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84733
IGROV-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10491
DIFI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
INO80C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44033
chemical synaptic transmission	GO Biological Process Annotations 2023	1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.786075
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.3546
ADO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50603
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.922993
HEY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26964
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02832
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A64Z-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30024
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.996824
ACCMESO1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07057
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0018
thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.222136
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46516
ZNF497	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92643
CPLX1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35939