association	dataset	threshold value	standardized value
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856745
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OSC20	DepMap CRISPR Gene Dependency	1.0	2.91022
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.491
10-methoxyharmalan-6355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.833794
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02699
Superior central nucleus raphe, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70549
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
etifenin-2838	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UTP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63644
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24794
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.99718
vancomycin-2858	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHA-00851261E-3857	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27451
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K14116382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16542
BRD-K16605233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89962
PMC4271336-13041_2014_88_MOESM6_ESM.xlsx-Genes_in_GENE_CARD_MR_or_ID-Gene_Cards_MR_and_ID_genes_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46653
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.09973
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2548
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6023-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08432
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.990993
LUC7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19547
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMOE-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
layer 4 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39486
pentetic acid-3387	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tranylcypromine-5996	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K77624847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19084
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41434
CSTB_KO_GDS5090_198_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43895
NR3C1	ChEA Transcription Factor Targets	1.0	null
CLPP_KO_GDS4791_374_mouse_Testies	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02152
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18979
SF539	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48
neoplasm of the lung	GWASdb SNP-Phenotype Associations	1.0	0.465228
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12359
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.35382
sirolimus-2667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11902
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
Nidopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.87445
AML193	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.07244
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5907-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03919
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53INP2_OE_GDS5054_387_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
haloperidol-5638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ankylosing spondylitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962855
POU3F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00498
layer 2 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06051
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4644-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62457
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34067
BRD-K30581008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51097
BRD-K50510710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30235
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.30823
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7887-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
786O	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.61882
BRD-K07988588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77327
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	2.03054
PHF8	ENCODE Transcription Factor Targets	1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
LB373-MEL-D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.934278
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHU011	DepMap CRISPR Gene Dependency	1.0	2.29551
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.154474
GSE229231_0_v_1_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26831
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88357881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19324
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101036
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-1.02018
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.645641
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	1.46516
Thymopentin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0147195
chenodeoxycholic acid-6012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K35970781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32124
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.076
homatropine-1684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0802
IGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63573
Facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33015
pathogenesis	GeneRIF Biological Term Annotations	1.0	null
atrophy/degeneration affecting the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.561769
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.038934
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66518
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.96831
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27881
nifenazone-6016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
valproic acid-2669	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40765512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17922
EM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73423
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08171
CRCGN015_MCF10A.TP53.M_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0154
difenidol-2374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2642
KYSE510	CCLE Cell Line Gene Expression Profiles	1.0	1.42213
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
HDAC1	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.051882
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.925971
X-linked intellectual disability-short stature-overweight syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.48
MAPK8IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51938
SW579	CCLE Cell Line Gene CNV Profiles	1.0	1.61691
EFE184	CCLE Cell Line Gene Expression Profiles	1.0	1.45192
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52682
EX229_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0158543
arteriosclerosis	GWASdb SNP-Disease Associations	1.0	0.664902
MTRES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20438
Doxycycline (monohydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191157
flucytosine-3073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02259
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83334
Mouse - Motor Cortex - Cluster - Pvalb+ Reln+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.949975
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00018
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81392
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WXYG-2226-SM-4E3IM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965923
thiamazole-3815	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
NUF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07396
r4 part of pontine raphe cell population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37966
BRD-K76742876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22071
Gemcitabine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0324851
BRD-K85234739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03823
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25341
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96764878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0395
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050012
netilmicin-6005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_7day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.57403
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
promazine-3833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dicycloverine-4405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00307
hsa-miR-875-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849172
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76311
staurosporine-423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CLPP_KO_GSE40207_388_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K13752834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86191
ZNF569	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59402
CA46	CCLE Cell Line Gene Expression Profiles	1.0	1.40124
cytokine receptor activity	GO Molecular Function Annotations 2015	1.0	null
NCI-H1436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-30a	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
tribenoside-3507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69918256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47226
NDUFS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18255
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14991
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8681
GSE164529_0_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2030	CCLE Cell Line Gene CNV Profiles	1.0	1.76791
ciclacillin-3800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931731
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.068548
Adenosine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0311303
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32172
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69766
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12178
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.164736
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37057
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fog2_KO_GDS3659_152_mouse_adult heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8054-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.7071
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24325
medial part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60132
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49401
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7615
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.02463
BRD-K55623459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.01278
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.86924
MALME 3M	BioGPS Cell Line Gene Expression Profiles	1.0	0.859513
dehydrocholic acid-1940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60175505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20445
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46219
ventral posterolateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40821
hypothesis	GeneRIF Biological Term Annotations	1.0	null
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36172
BRD-K20073772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48794
GSE95771_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
monastrol-610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mental Retardation	DisGeNET Gene-Disease Associations	1.0	null
PHF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60161
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX1	ChEA Transcription Factor Targets	1.0	null
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UACC-257	GDSC Cell Line Gene Expression Profiles	-1.0	-1.72412
BRIX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86651
Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Methionine	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0685
disease	GWASdb SNP-Disease Associations	1.0	0.044071
sulfabenzamide-2814	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARNT-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K67520049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24575
hsa-miR-30d	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050047
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32196
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26929
BRD-K21407905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57403
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00772292
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ventral posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46944
0317956-0000-3969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857129
SCAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37632
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02088
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962153
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.848423
FECH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6127
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3913
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0431
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00774
ifosfamide-5805	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
polymyositis	GeneRIF Biological Term Annotations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.857984
single	GeneRIF Biological Term Annotations	1.0	null
Ivermectin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220692
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22135
BRD-K55106539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06691
further	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09611
cellular_component	GO Cellular Component Annotations 2015	1.0	null
POSTN_01_293	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.74598
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104376
idazoxan-3088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arcopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.84912
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A172	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20312
Bed nuclei of the stria terminalis, posterior division, transverse nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15317
Prostate adenocarcinoma_PRAD_TCGA-SU-A7E7-01A-22R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4987-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abiraterone acetate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0397559
ZC3H11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18567
STAT5_01_279	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.36734
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04901
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841827
disease by infectious agent	GWASdb SNP-Disease Associations	1.0	0.151342
bacampicillin-4417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MFE280	DepMap CRISPR Gene Dependency	1.0	3.34274
Cepharanthine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0413599
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
galantamine-4186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21153
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13742
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18358
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08006
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873269
ketoconazole-4624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_14496_KD_BCLIN25_SRP326142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.892009
suloctidil-6675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AT7519_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.039531
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1594
BRD-K70518736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06512
mantle zone of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83947
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36744
diphenhydramine-1830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.904829
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6117
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5457-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Levobupivacaine (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0303202
glucose metabolism disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
HTRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36589
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.90839
BRD-K85802892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44207
KE97	CCLE Cell Line Gene Expression Profiles	1.0	1.49519
Mouse - Motor Cortex - Cluster - Pvalb+ Vipr2+ GABAergic neuron_2	HuBMAP Azimuth Cell Type Annotations	1.0	null
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27524
GTEX-T2IS-1526-SM-32QPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19051
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
IRF1	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47667
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9244
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.181618
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52213
Everolimus_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0305382
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31254
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.245175
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mebendazole_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.037077
BRD-K52254237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0341
USP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05165
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.791213
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pyrimethamine-4194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09314
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867688
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.17958
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JHOS-4	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
FOXD4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01119
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.94027
interleukin-1 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.702
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19597
Pelizaeus-Merzbacher disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.397
BRD-K30625175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2452
BRD-K58168959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07269
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.47803
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07895
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.59631
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.887983
SMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65643
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76788397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6589
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	72.5135
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864412
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39775
betamethasone-dipropionate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01911
ZNHIT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31626
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27542
sulfadimidine-4322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061003
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66879
BMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90655
KCTD20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16016
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.12945
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
metoclopramide-4750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A39521712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21498
MCF7_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213034
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24397
GSE198228,GSE198245_0_v_2_apoe_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.21402
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2684
GTEX-WI4N-1426-SM-3LK7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00268
intermediate stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16642
levobunolol-4016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14956
CAOV4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
lidocaine-4421	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SF126	Achilles Cell Line Gene Essentiality Profiles	1.0	1.74742
loperamide-5267	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89216
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15602
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
Anterior hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06487
galantamine-4772	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USP2_KO_GSE43517_20_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27692
MJ	DepMap CRISPR Gene Dependency	1.0	2.77694
H3K9me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
lithocholic acid-2571	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Human - Motor Cortex - Cluster - RORB+ TNNT2+ Layer 3-5 glutamatergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
Otx2_KO_GDS4440_143_mouse_fourth ventricular choroid plexus tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Ropivacaine (hydrochloride monohydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.023003
ERCC6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53582
periventricular stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03404
beta-escin-2194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24661
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluphenazine-2697	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
telenzepine-2388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K71590663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12655
intermediate stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41895
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4325-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894753
BRD-K74547048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16416
Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.124027
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32314
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89746
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49265
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AHR	ChEA Transcription Factor Targets	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56291
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A5NE-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32731
Anterior cingulate area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01711
BEN	CCLE Cell Line Gene Expression Profiles	1.0	2.25277
BRD-K76477096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13462
CYTH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97257
Dexmedetomidine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0327906
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.10665
ciclosporin-4586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62338
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
5194442-6599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNT34	Achilles Cell Line Gene Essentiality Profiles	1.0	1.65734
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77975
type 2 diabetes mellitus	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.894785
ZNF263	ENCODE Transcription Factor Targets	1.0	null
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45021
R3HDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46643
Orlistat_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240502
RBSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58449
BRD-K76510844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02091
pontine raphe nucleus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0662
PHA-00767505E-6596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69129
membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UQCR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50505
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.850582
Hypomyelinating leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-NR3C1_targets_enrichment-Unnamed_23_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
C2CD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27822
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.9768
BRD-K59455917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64776
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26695
CP-320650-01-4379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6576
CSTB_KO_GDS5089_169_mouse_Cerebrellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86300178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06064
layer 2 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22233
SKCO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.41778
Amyotrophic Lateral Sclerosis	dbGAP Gene-Trait Associations	1.0	0.082851
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17907
BRD-K25822126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1001
GSE95771_0_v_4_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DES_KO_GDS4804_171_mouse_young skeletal muscles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55803
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Pimitespib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0326036
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00622
Somatomotor areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14756
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852345
leflunomide-5884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
merbromin-2577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
interleukin-27 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.189
idoxuridine-4200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CP-320650-01-3905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88727
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28761
NCI-SNU-5	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02325
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00155
HCC1187	DepMap CRISPR Gene Dependency	1.0	11.2382
phenelzine-3802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BECKER	CCLE Cell Line Gene Expression Profiles	1.0	1.83172
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T98G	DepMap CRISPR Gene Dependency	1.0	3.28315
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15844
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1066
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03331449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44815
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05175
SLC38A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14129
Brain Lower Grade Glioma_LGG_TCGA-HT-7474-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
MED23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42893
CDC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4913
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26708
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6426
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21119
clofibrate-444	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26019
BRD-K48228567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67152
fluorocurarine-2521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.11521
Human - Motor Cortex - Cluster - RORB+ MED8+ Layer 5 glutamatergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53147
r3 pontine raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4953
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08112
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9605
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830508
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20267
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-0926-SM-4DXU4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828241
oligomycin-442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FM-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dimethadione-3367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27059
Lung adenocarcinoma_LUAD_TCGA-91-6847-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oxaprozin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0417587
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-H6-8124-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCLFPEDS0008T	DepMap CRISPR Gene Dependency	1.0	3.25485
Interleukin-1 receptor type II	InterPro Predicted Protein Domain Annotations	1.0	null
NO11	DepMap CRISPR Gene Dependency	1.0	5.0739
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8432
receptor activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K84846130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86563
TCF4	ChEA Transcription Factor Targets	1.0	null
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.36246
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
OCIAML3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92896
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896248
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.828958
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09335
BFTC-905	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73825
mecamylamine-3525	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
arthropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.511112
DMS-114	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71184
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wilson-Turner syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.751
BRD-K50976856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55971
E2F1	ChEA Transcription Factor Targets	1.0	null
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.896331
layer 4 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15932
MZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960958
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98176
Lung adenocarcinoma_LUAD_TCGA-97-7554-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36092
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AU565	CCLE Cell Line Gene CNV Profiles	1.0	1.87309
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33244
furaltadone-3932	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K36558227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1235
BRD-K57719270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19059
Idarubicin (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0280971
flecainide-3843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
viral infectious disease	GWASdb SNP-Disease Associations	1.0	0.23831
TBP	ENCODE Transcription Factor Targets	1.0	null
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54086
SUDHL8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34683
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39798
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.03845
KCNIP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04924
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34503
physostigmine-5749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.49001
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.47711
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.16821
DENR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57788
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50941
GSE205976,GSE205978_3_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
sotos syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.38603
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.960568
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38519585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55931
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6339
josamycin-2034	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21732
NCIH747	CCLE Cell Line Gene CNV Profiles	1.0	1.37036
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19635
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7241
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2932
chlorcyclizine-6053	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H841	COSMIC Cell Line Gene CNV Profiles	1.0	2.14702
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17109
cytokine receptor activity	GO Molecular Function Annotations 2025	1.0	null
SNU81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49948
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14608
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Doxorubicin (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0261494
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.22799
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
developmental process	GO Biological Process Annotations 2015	1.0	null
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31504
5155877-6569	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of synapse assembly	GO Biological Process Annotations 2025	1.0	null
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66089
Muckle-Wells syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Fumaric acid_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0225594
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14432
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
butacaine-2728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nystatin-4807	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8381
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6227-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
upper basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05646
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CSTB_KO_GDS5089_486_mouse_Cerebellum and granule neurons	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NCIH841	CCLE Cell Line Gene CNV Profiles	1.0	2.10219
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70605
Fostamatinib (disodium hexahydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0229878
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95537
Mouse - Motor Cortex - Cross-Species Cluster - Sst+ GABAergic neuron_2	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11297914-41389_2024_531_MOESM1_ESM.pdf-228-ZNF277_ZNF277	Rummagene Transcription Factor Associations 2026	1.0	null
homochlorcyclizine-2386	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3331-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01699
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
Bimatoprost_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0341488
Caudoputamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08868
ZR751	CCLE Cell Line Gene Expression Profiles	1.0	2.0902
RWDD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33902
quinpirole-3539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Spastic quadriplegic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
Taproot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
TGFBR2_KO_GDS5008_282_mouse_Embryonic palatal mesenchymal cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
chlormezanone-3235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAB3A_Mutation - D77G point mutation_GDS2483_697_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.5417
EIF4G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22808
phenylpropanolamine-6699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
MUTZ5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32952
MELHO	DepMap CRISPR Gene Dependency	1.0	8.26285
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.64158
HNF4alpha_KO_GDS1915_173_mouse_Small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC10657376-41467_2023_43213_MOESM7_ESM.xlsx-DaNs_EBF1-Unnamed_6_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF7_01_342	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59554
Hyperimmunoglobulinemia D periodic fever syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08252
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46196
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903625
etofylline-1409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIRT1_KO_GDS3666_295_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10524
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.603
SARS-BatSRBD_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89708
Vortioxetine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170969
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K22691925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2952
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pemetrexed_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0314641
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15495
HT29	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.34301
glafenine-2387	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hs-578-T	GDSC Cell Line Gene Expression Profiles	-1.0	-2.70961
Pexidartinib (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152438
r2 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03404
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLPP_KO_GDS4791_107_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K27363274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20335
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Matrilin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33961
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K33767317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22452
BRD-K63197664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29833
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.092
Megestrol_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0214521
stachydrine-6805	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epirizole-1803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE124410_3_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100663_TCx_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03156
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7181
CRCGN009_HEPG2_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01233
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA2	ChEA Transcription Factor Targets	1.0	null
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.836504
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.21762
KP4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7402
GREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14141
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.14562
Protein-protein interactions at synapses	Reactome Pathways 2024	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6562
FEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29256
(-)-MK-801-6657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CP-320650-01-3822	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75557837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41255
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	3.13924
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4651
regulation of presynapse organization	GO Biological Process Annotations 2023	1.0	null
BRD-K00300115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12674
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RH-18	GDSC Cell Line Gene Expression Profiles	1.0	1.93926
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.34265
spiramycin-3844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I4-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28263
Middle temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3498
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64294
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52337
A498	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NEUROD1_Deficiency_GDS3000_612_mouse_Pineal glands of neonates	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04264
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60082
rofecoxib-463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16279128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08782
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.72072
GSE221101_1_v_0_hopx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Auranofin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0566321
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lonafarnib_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00366194
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.955883
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.099166
MDAMB436	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17137
EWSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8918
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4267
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5184
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00861
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.13868
A1BG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.386
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19149
Hidradenitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
LY-294002-2676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40405
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS766T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.605
Sarcoma_SARC_TCGA-MO-A47R-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.92231
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.008
carbarsone-3991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.974709
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55160477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09513
USP2_KO_GDS5079_25_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839852
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.991199
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.36418
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909283
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.55946
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55318
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
trichostatin A-2208	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09622
Malotilate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.047635
HS939T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80228
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.978699
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sulindac sulfide-308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90660470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39343
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A50M-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36935
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37785
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.65302
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
posterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843814
minaprine-4230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
separase-securin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20626
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33459
regulation of presynapse assembly	SynGO Synaptic Gene Annotations	1.0	null
central nervous system development	GO Biological Process Annotations 2023	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4978
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12455
SNU626	DepMap CRISPR Gene Dependency	1.0	2.71073
L-Thyroxine (sodium salt pentahydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0262439
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
MET_knockout_264_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63819
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.90337
Diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98195
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35176035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.539
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OV7	Achilles Cell Line Gene Essentiality Profiles	1.0	1.56236
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.936543
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19351
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.071613
GSE147662_3_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08808
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03719
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r2 part of median raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30962
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.00142
SFMBT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39157
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.723871
BRD-K63252672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2255
mantle zone of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02495
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163052,GSE163198_2_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r3 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0204
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.791213
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966836
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHA-00745360-3824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65587
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69943
Lung adenocarcinoma_LUAD_TCGA-55-6981-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PITPNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0176
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mouse - Motor Cortex - Cluster - S100b+ Layer 5 glutamatergic neuron, intratelencephalon-projecting_1	HuBMAP Azimuth Cell Type Annotations	1.0	null
5-Azacytidine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0335708
levobunolol-3015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46309
HCC1187	CCLE Cell Line Gene CNV Profiles	1.0	1.40577
vascular disease	GWASdb SNP-Disease Associations	1.0	0.141971
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.885848
MedullaOblongata	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.06453
GSE204752_2_v_0_sotorasib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bimiralisib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0425704
intermediate stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92724
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.823841
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11988
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.073645
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.92231
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1909
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53445
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38155
dapsone-1827	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gallamine triethiodide-5735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25935
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_858_KO_Lrp2_SRP134101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.31056
convolamine-5876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KELLY	CCLE Cell Line Gene CNV Profiles	1.0	1.52781
altretamine-4627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70668
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signal transduction	GO Biological Process Annotations 2015	1.0	null
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53504
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.94318
LY-294002-461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.82909
Crizotinib (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0205775
hydroxyachillin-2812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964103
molecular_function	GO Molecular Function Annotations 2015	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32912
chlorphenesin-1432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4397
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-30e	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3579
H3K27me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-01A-12R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0521
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
ciclosporin-4411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21714
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19096
BRD-K74324157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66161
A2058	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56147
DDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00951
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67Y-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6873-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827309
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE166004_3_v_2_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833607
lymph node	HPA Tissue Protein Expression Profiles	1.0	1.6135
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887398
PMC12152148-41420_2025_2541_MOESM3_ESM.xlsx-AR-IP-DHT_peak-gene-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
sulfadimidine-3940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trioxysalen-2516	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SUZ12_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TSEN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70758
Glycyrrhizic acid_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0197959
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29A-06A-12R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30467307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8632
Necrosis	CTD Gene-Disease Associations	1.0	1.26825
PMC7005888-41598_2020_58845_MOESM2_ESM.xlsx-Insulinoma-INSM1_INSM1	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.953733
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
telenzepine-5096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	2.0116
scopolamine N-oxide-6335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12578029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20265
LY-294002-429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.42735
Adenine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202703
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52061
Aspirin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0348182
ZXDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10956
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08517
intermediate part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59164
Methylthiouracil_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214344
PMC4591983__F6	PFOCR Pathway Figure Associations 2024	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13999
sisomicin-4014	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
meprylcaine-6123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K60237462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15307
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67899
BRD-K85359206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68213
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.54921
TFAP2A-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01661
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71128
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K33005275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1712
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25522
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
ESRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05312
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5557
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Immunoglobulin-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myositis	DisGeNET Gene-Disease Associations	1.0	null
ARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82131
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
ceforanide-5351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lower dorsal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92374
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Phenylephrine (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0214873
oral mucosa	HPA Tissue Protein Expression Profiles	-1.0	-1.49001
GTF3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24396
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Allopurinol_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0332126
TMEM63B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68164
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09449
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K22597651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68272
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3689
benfotiamine-2177	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
stratum oriens of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.982535
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65841
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09831
bucladesine-5886	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypermobility syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.57913
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2037
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933225
BRD-K02321382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0375
8-Hydroxyquinoline_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146272
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4612
NRK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
TDOTT	DepMap CRISPR Gene Dependency	1.0	2.70561
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r3 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03604
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QT-1726-SM-2S1NQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843827
Systemic lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
MCF7_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120838
Nucleus reuniens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.036395
BRD-K33151492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03224
BRD-K11873306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12445
RAD21	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A6FZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4332
NCI-H1092	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ONDA9	DepMap CRISPR Gene Dependency	1.0	2.05821
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP2A	ChEA Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5875-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of immune system physiology	GWASdb SNP-Phenotype Associations	1.0	0.105755
pioglitazone-7506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64164
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Almonertinib (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0368087
Mouse - Motor Cortex - Cluster - Pvalb+ Kank4+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DMD_Deficiency_GDS2996_614_mouse_Cardiac muscles from 10.5-month (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24687
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5119-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03156
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13011
BRD-K41719231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01954
SW626	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53563
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09988
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
HUNS1	CCLE Cell Line Gene Expression Profiles	1.0	1.55334
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trimethadione-4165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amyotrophic lateral sclerosis	GAD Gene-Disease Associations	1.0	null
CSTB_KO_GSE47516_677_mouse_mouse cerebellum P7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
AHR-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
intermediate part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05488
SMARCA4	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6543-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1299	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33736
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59088
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02152
PMC6754502-41598_2019_50051_MOESM3_ESM.xlsx-Br_to_Fay_Heat_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5459
Familial Mediterranean fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
cicloheximide-2723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05098
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20096
BRD-K53772256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0773
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02918
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
G292CLONEA141B1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95833
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13742
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99588
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5137
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0426-SM-2XCEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22694
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
aclarubicin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5167
orphenadrine-3801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bladder	GTEx Tissue Gene Expression Profiles	1.0	0.899743
SCRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33158
atropine-2761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r8 part of the paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21249
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19835
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.41743
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24987
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.97203
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PA-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARMCX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0838
BMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70986
3-hydroxy-DL-kynurenine-2654	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.4737
RH41	CCLE Cell Line Gene Expression Profiles	1.0	2.65491
Hypermobility syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
Homoharringtonine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146045
BRD-K79032360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51694
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962285
NCIH446	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69997
BRD-K38450726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08965
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11304
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.21212
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
IgSF CAM signaling	KEGG Pathways 2026	1.0	null
Entorhinal area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
Lipoic acid_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0464675
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2508
OTS514_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0449903
proxymetacaine-5433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1372
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.445915
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-01A-32R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.657677
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-SY-A9G5-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11547
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70665
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05168
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98013
sulfadimethoxine-2578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09553491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14182
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1066
IST-MEL1	GDSC Cell Line Gene Expression Profiles	1.0	1.5215
RAB3A_KO_GDS2483_700_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.1268
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99819
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24894
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.22007
Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
Lactate (calcium)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168206
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00212
GATA4_Deletion - for the second exon_GDS2316_712_mouse_Heart ventricles (of GATA4 animals heterozygous)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	2.35448
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAMA84	Achilles Cell Line Gene Essentiality Profiles	1.0	1.08151
hsa-miR-4301	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68285
hsa-miR-30c	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
mantle zone of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59164
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.22484
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51108
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lapatinib ditosylate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0304538
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.937
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Choline	CTD Gene-Chemical Interactions	1.0	null
BLOC1S6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46149
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892828
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55393423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47624
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A43135847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09819
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.15614
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05381
HDAC2	ENCODE Transcription Factor Targets	1.0	null
PMC9692021-Table_4.xlsx-Table_S4-Table_S4_405_DEGs_of_RA_synovial_tissues_between_NFIL3-high_and_NFIL3-low_group_NFIL3	Rummagene Transcription Factor Associations 2026	1.0	null
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.983399
U266B1	CCLE Cell Line Gene Expression Profiles	1.0	1.69365
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trifluoperazine-4448	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41628
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03302
pirenperone-5274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.01505
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
STARD3NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18445
C1QL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21239
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.31169
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1535
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.839625
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XN-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.67687
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102261
BRD-K23840704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55002
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
trifluoperazine-2684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
BRD-K89811208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90651
UMRC6	CCLE Cell Line Gene Expression Profiles	1.0	1.35468
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
p2 part of the zona limitans core population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27327
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.73209
PMC9396374-Table_5.XLSX-Table_S5-AR_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12382
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.1521
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
frontal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02456
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bendroflumethiazide-3934	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858262
DKMG	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04727
MD MB231	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24805
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mouse - Motor Cortex - Cluster - Perivascular macrophage	HuBMAP Azimuth Cell Type Annotations	1.0	null
superior periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77485
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
yohimbic acid-4082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
MTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23855
BRD-K21683946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14129
BRD-K16305571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0661
2,6-dimethylpiperidine-3806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78832647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24021
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841024
PMC11913834-Table2.xlsx-CEBPB_bound_geneset-Gene_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
Chlorhexidine (diacetate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0300031
10-methoxyharmalan-5455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08866
BRD-K76415725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73702
AR	ChEA Transcription Factor Targets	1.0	null
Human - Motor Cortex - Cluster - RORB+ LINC01202+ Layer 3-5 glutamatergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26652
rofecoxib-371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58775
Ectodermal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23935
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201239_6_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Goserelin (acetate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0328857
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830678
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amorolfine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04204
DOT1L_DELETION_GDS4295_428_mouse_AF9 - Mixed Lineage Leukemia (MLL) cells -  7 days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
superficial stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21249
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56577
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.99135
praziquantel-5874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
septostriatal transition area (accumbens)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00254
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05668
CP-690334-01-4558	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A15798299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16091
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02415
Imiquimod (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0121262
NCIH1838	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46853
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
accessory entopeduncular nucleus (post-migratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25875
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyrithyldione-2740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
eldeline-2171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Darinaparsin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0322164
Dorsal premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46645
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04315
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
troglitazone-4456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	2.61568
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.06442
arachidonic acid-441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R3RS-0626-SM-48FE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958988
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27967
CMTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28652
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15643
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62705
H3K9me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TDRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51651
NMC-G1	COSMIC Cell Line Gene CNV Profiles	1.0	2.14702
Lung adenocarcinoma_LUAD_TCGA-95-7948-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of FCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02537
Nucleus accumbens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05975
DOK	DepMap CRISPR Gene Dependency	1.0	2.73414
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PH-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891144
BRD-K71585907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23027
Acetohexamide_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0181147
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19314
SP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23691
diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dimenhydrinate-2400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4865-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glycerol kinase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
NUGC4	CCLE Cell Line Gene Expression Profiles	1.0	1.50461
medial part of r2B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18113
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.853126
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.47197
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Connective tissue progenitor cell_Embryo_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02362
Proteinuria	CTD Gene-Disease Associations	1.0	1.49278
olaparib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0280298
BRD-K07536006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42739
Rheaume et al.Nat Commun.33_Retina_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Primary somatosensory area, mouth	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00453
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1011
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13493
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pyloric cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
methapyrilene-4990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bufexamac-2382	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56314
cefadroxil-4161	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26018
Thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849172
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02609
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
A-61603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31396
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26708
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23169
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47404
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19716
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18127
nervous system development	GO Biological Process Annotations 2023	1.0	null
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.00026
Prestwick-682-2819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC-78	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
Lung squamous cell carcinoma_LUSC_TCGA-22-5477-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53954
LNZ308	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.22445
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nipecotic acid-5999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06031
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6646
Azithromycin (hydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0351153
vincamine-3865	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SH3D19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10175
NCIH1693	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-7643-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30058879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86941
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92251
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02082
Prostate adenocarcinoma_PRAD_TCGA-EJ-5501-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.80256
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45196
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Mewo	GDSC Cell Line Gene Expression Profiles	1.0	1.43415
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oxyphenbutazone-6160	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08908
skimmianine-2504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
interleukin-1 receptor activity	GO Molecular Function Annotations 2023	1.0	null
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956948
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.973146
AGS	Achilles Cell Line Gene Essentiality Profiles	1.0	1.29259
lynestrenol-2037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
crizotinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0212495
BRD-K07462139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03735
BRD-A60877539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05386
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
adipiodone-3111	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19716
CRCGN017_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76405
Bergenin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0434897
amyotrophic lateral sclerosis	GWASdb SNP-Disease Associations	1.0	0.658446
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29045
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41879
BDCM	CCLE Cell Line Gene Expression Profiles	1.0	1.41382
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0043
ZNF626	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68531
BRD-K96154586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6816
BRD-K35122752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86881
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02024
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03719
ventral nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44918
NCIH1385	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00401
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	2.04966
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05648
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952832
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
interleukin-1, type ii, blocking receptor activity	GO Molecular Function Annotations 2015	1.0	null
amyotrophic lateral sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.561769
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20094
OCI-AML5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88051295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25836
CORL88	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65081
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.916243
tropine-6147	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27666
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol-4465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02863
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27011
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.25165
fludrocortisone-3866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thioridazine-4085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31447
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953948
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.908514
florfenicol-6701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.830559
hepatitis	GeneRIF Biological Term Annotations	1.0	null
HCC70	COSMIC Cell Line Gene Mutation Profiles	1.0	null
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.41173
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
phenazopyridine-5758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Tegmental reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61013
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.830817
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS870T	CCLE Cell Line Gene Expression Profiles	1.0	1.88475
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.130498
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955695
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
Orbital area, medial part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14523
raloxifene-2738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00554
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.798699
NCI H226	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.26585
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.67845
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.88615
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01952
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.22175
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8024
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4858740-ncomms11473-s2.xls-HAdV-D9_Cr1b_Library_2-Hit_name_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38921908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45062
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
X-linked deafness 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.641
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51355
intermediate stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32919
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5748
Rifaximin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189207
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5807
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30303
Fatty Liver	CTD Gene-Disease Associations	1.0	1.03345
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.826422
Gly-His-Lys-6570	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of body height	GWASdb SNP-Phenotype Associations	1.0	0.702831
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-syndromic X-linked intellectual disability 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16841
SJRH30	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
bromopride-2182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neratinib (maleate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.036113
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MOLP8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37048
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.097407
Pentagastrin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02207
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.921517
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Isocorydine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0208965
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36505
mantle zone of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06319
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33615
vitexin-4413	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848954
Schinzel-Giedion Syndrome	DisGeNET Gene-Disease Associations	1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.2427
BRD-K96970199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28947
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-11A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Selinexor _BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154478
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15967
SW156	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.971255
aminocaproic acid-7258	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.18321
nervous system development	GO Biological Process Annotations 2025	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.833412
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.960568
PMC4591983__F6	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K37457040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61083
inner CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.91584
etanidazole-5730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
xq111q2133	GeneRIF Biological Term Annotations	1.0	null
BRD-K09206831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55431
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24003
CTCF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0073515
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5312
urinary bladder	HPA Tissue Gene Expression Profiles	1.0	1.10694
CTCF_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28228
RNA helicase p68_KD_GDS2152_626_mouse_skeletal muscle cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
diflorasone-4077	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03379
noscapine-1753	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.044156
AFF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06568
Gene duplication disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9163
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.82984
BRD-K37203945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08596
spiramycin-4319	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.08726
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905252
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Mouse - Motor Cortex - Cross-Species Cluster - Layer 6 glutamatergic neuron, intratelencephalon-projecting_1	HuBMAP Azimuth Cell Type Annotations	1.0	null
SCC4	CCLE Cell Line Gene CNV Profiles	1.0	2.36415
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08368
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18181
chlorcyclizine-2197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nucleotide-excision repair factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.55
Mouse - Motor Cortex - Cluster - Pvalb+ Gpr149+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
aminophylline-5395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tubulin inhibitor 6_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188519
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.891912
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
sulfathiazole-4183	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mouse - Motor Cortex - Cluster - Car3+ glutamatergic neuron, intratelencephalon-projecting	HuBMAP Azimuth Cell Type Annotations	1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1275
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8112
controls	GeneRIF Biological Term Annotations	1.0	null
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.49001
Berberine (chloride hydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0330611
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2273
periventricular stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00008
thioridazine-5916	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4244-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00952
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02128
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
OCRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08359
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918577
BRD-K00233837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78427
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926453
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41986
Apalutamide_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0275834
frontal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06372
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95479
BRD-K54837534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55909
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827503
TGFBR2_knockout_295_GSE45968	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.67023
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03827
SKN3	DepMap CRISPR Gene Dependency	1.0	3.98424
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.0588
system development	GO Biological Process Annotations 2015	1.0	null
PLEKHH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16126
NCIH1339	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
vanoxerine-4641	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pontine nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.87216
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99358
IBMX	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3584
PMC4504419-13229_2015_34_MOESM2_ESM.xlsx-Sheet1-Additional_File_2_-_Genes_with_at_least_two_rare_MAF_0_01_damaging_SNVs_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.30931
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43594798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23248
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vilanterol_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0267917
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3609
presubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39971
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
NCI-H1869	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-2726-SM-4BOQ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849191
BRD-K43472599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07023
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4836-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lenalidomide (hemihydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0372453
cancer	GWASdb SNP-Disease Associations	1.0	0.036862
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Subthalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78052
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.992587
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	2.25272
mantle zone of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00008
flunisolide-6023	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hmgn1_KO_GDS5010_407_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65136
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83908
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83859
ZNF143	ENCODE Transcription Factor Targets	1.0	null
DOT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90315
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuronal System	Reactome Pathways 2024	1.0	null
studies	GeneRIF Biological Term Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00419
RAD21_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymecycline-5994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95235
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75024
BRD-K07476637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04023
cyclic adenosine monophosphate-3531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K01973494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50568
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0501
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.06261
KCNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28146
Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66851
Superior central nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85731
hsa-miR-4257	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Quinestrol_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013467
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02585
BRD-K18481678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04456
BRD-K88968415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58468
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5180-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4766-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL120	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42064
BRD-K91470977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62796
Prestwick-674-2179	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
known	GeneRIF Biological Term Annotations	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AZD2858_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.026358
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rhinovirus infection_Nose_GSE11348	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.4065
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944476
TAF15-26573619-CHIP-SEQ-HEK293-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23742
CTCF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIF4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13967
MTF2	ChEA Transcription Factor Targets	1.0	null
RPMI-7951	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65946
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
betahistine-2833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rapamycin vs Ctrl Exp2 MEFs (Mouse) [21659605]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	-1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.8692
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7503
FUS-26573619-CHIP-SEQ-HEK293-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8191
Entorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34344
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0131
BRD-K46211110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32774
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
GLO1_OE_GDS4991_546_mouse_anxiety disorders	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
paracetamol-3364	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
alprostadil-6571	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35151
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71163
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.848423
CLPP_KO_GDS4791_104_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.404931
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3987
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19525
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rostral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71163
thiamphenicol-1826	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RCHY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60952
Superior olivary complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89007
RAGE_knockout_269_GSE22873	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.52662
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
Niclosamide (olamine)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0282279
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metamizole sodium-3835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Familial cold autoinflammatory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3385-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sivelestat (sodium tetrahydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255078
trazodone-2379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.042528
warranted	GeneRIF Biological Term Annotations	1.0	null
LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56314
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7169
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46295
rostromedial tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08388
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01932
NCIH660	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62421
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.071996
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
cerebellar white matter	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00159
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
selegiline-4065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K02199688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01909
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27755
Excitatory synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.176
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36994
calcium folinate-2579	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
epirizole-5995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K93956318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77343
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EH-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K62511324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.354
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44818
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33603
SMAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43393
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.0561
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69454
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880399
BRD-K16588281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26415
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.6888
Artesunate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0276634
PMC3827940-2045-3329-3-12-S1.docx-1-Supplementary_Table_2_Minor_allele_frequencies_MAF_and_p-values_for_comparison_of_genotype_frequencies_Z9001_genotyped_whites_n_273_versus_non-whites_n_58_1_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20807411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1267
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53489056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48809
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Autism	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-GK-A6C7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Interleukin-1 receptor family	InterPro Predicted Protein Domain Annotations	1.0	null
epitiostanol-4204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
JUND	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MR-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.30029
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33549
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8311
diphenylpyraline-2205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	0.978433
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.512
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84239
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cell surface	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02006
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14212
GTEX-S4UY-0926-SM-4AD6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07738
HSPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27762
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129208
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.07324
MOLT4	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.954142
AGS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0195
Entrectinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221492
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75502
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953734
glutamatergic synapse	GO Cellular Component Annotations 2025	1.0	null
strychnine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46247
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
SARM_KO_GDS4842_412_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Brimonidine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0385194
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
moracizine-6000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
furaltadone-2554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
biological_process	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83581
amrinone-2724	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83451
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9009
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8678
L-428	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A770-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.902115
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11266
BRD-K65541951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03621
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28911
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
diperodon-4498	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052622
HCC1599	CCLE Cell Line Gene CNV Profiles	1.0	1.93542
Fatty Liver, Alcoholic	CTD Gene-Disease Associations	1.0	1.06588
GTEX-TML8-1226-SM-32QON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05333
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANKMY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75607
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0843
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919129
six	GeneRIF Biological Term Annotations	1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9617
ANKRD27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22811
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849172
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02317
RAD21_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A91404865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84413
striatum (corpus striatum)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11858
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	1.67545
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SF172	CCLE Cell Line Gene Expression Profiles	-1.0	-1.551
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RAD21_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
securinine-2729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ALX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14191
iopamidol-2732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
motor neuron disease	GWASdb SNP-Disease Associations	1.0	0.658446
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03056
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2296
ERG_01_17	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59637
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO680N	CCLE Cell Line Gene CNV Profiles	1.0	2.20038
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64043
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79295
H3K27me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pdx1_22135308_duodenum_lof_mouse_gpl1261_gds4348	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.963879
PMC10828500-41467_2024_44701_MOESM4_ESM.xlsx-ST12-Unnamed_7_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0426-SM-3TW8J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83423
anabasine-2512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LCLC-97TM1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1976
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33706
Daudi	GDSC Cell Line Gene Expression Profiles	1.0	2.20505
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.063745
KLF7_KO_GDS2069_68_mouse_olfactory epithelia	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.081075
lung cancer	GWASdb SNP-Disease Associations	1.0	0.545697
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.723871
SAP30	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP400	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73985
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886169
NCIH1355	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
Striatum dorsal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08735
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	1.84615
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840732
MFE319	DepMap CRISPR Gene Dependency	1.0	3.47866
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37742
dexamethasone-6271	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cabozantinib (S-malate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0571142
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5034
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86511
Fusidic acid_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0477494
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72591
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.3696
IGR1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.15046
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
lipid metabolism disorder	GWASdb SNP-Disease Associations	1.0	0.664902
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
KML1	DepMap CRISPR Gene Dependency	1.0	2.82712
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Vemurafenib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0299322
Perturb_4166_KO_Bcl11a_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.8623
NCIH1755	DepMap CRISPR Gene Dependency	1.0	8.32525
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98913
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
artery disease	GWASdb SNP-Disease Associations	1.0	0.18842
BRD-K43384508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03702
saquinavir-6246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
COLO205	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.53505
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56609
Parasubthalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35104
Child Development Disorders, Pervasive	CTD Gene-Disease Associations	1.0	1.09471
OVCAR-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.93541
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94938
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain_CT2_Splat 238	HuBMAP ASCT+B Annotations	1.0	null
KMS20	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00062
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.909946
nadolol-4139	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04965
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Aprepitant_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284239
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4208
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
piribedil-5434	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.57536
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2983
BT20	CCLE Cell Line Gene CNV Profiles	1.0	1.73006
RAB3A_KO_GDS2483_701_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
KLE	DepMap CRISPR Gene Dependency	1.0	2.09451
fludrocortisone-4342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pentoxifylline-2127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.023
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
central nervous system development	GO Biological Process Annotations 2015	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L8-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5883-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE-50	COSMIC Cell Line Gene Mutation Profiles	1.0	null
regulation of synapse assembly	GO Biological Process Annotations 2023	1.0	null
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAK-901_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0141167
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08523
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.800744
ADAM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49231
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03048
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.994916
NCIH854	CCLE Cell Line Gene Expression Profiles	1.0	1.98648
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.984782
Tubulin inhibitor 6_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0213337
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
LS411N	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.77184
cyclopentolate-6132	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2191
triamterene-1819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22486
clopidol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8919
geldanamycin-611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRDM16-22522345-PALATE_MESENCHYMAL-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69992
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40189164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78519
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28478559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53383
TOMM40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10925
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3792
superficial stratum of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40042
NCIH647	CCLE Cell Line Gene Expression Profiles	1.0	1.37184
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834021
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.95462
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09267
POM121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74012
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02002
KM12	CCLE Cell Line Gene Expression Profiles	1.0	1.55501
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-2672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16902
RAMOS-2G6-4C10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mestranol-3346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.5396
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
molindone-4199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OTX2_KO_GDS4440_424_mouse_brain (fourth ventricular choroid plexus)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19096
Fingolimod (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.015191
BRD-K36841620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34946
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04618
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10781
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00804747
biperiden-5644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Syndromic X-linked intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
skin	GTEx Tissue Gene Expression Profiles	1.0	1.22654
thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.538
bucladesine-2741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Toll/interleukin-1 receptor homology (TIR) domain	InterPro Predicted Protein Domain Annotations	1.0	null
estradiol-1633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Meningococcal infection_Umbilical vein_GSE4646	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.12571
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44577
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.5116
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10735
Abemaciclib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204252
Hexylresorcinol_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217526
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63199400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10129
Fetal Kidney	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.933229
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05236
BRD-K28446462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87202
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19286929-SuppTable2j	GeneSigDB Published Gene Signatures	1.0	null
intermediate stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01549
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48131
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58487
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.905159
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33603
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PIK3R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35393
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47021
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
COLO684	DepMap CRISPR Gene Dependency	1.0	3.81348
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5552-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.754934
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SBI-0640756_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0441682
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30367
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
positive	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7899
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836604
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01059
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
il1	GeneRIF Biological Term Annotations	1.0	null
BRD-K27616520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41412
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43545
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8526
CHD2	ENCODE Transcription Factor Targets	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33271
Pasireotide (acetate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0190804
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.596626
SUZ12_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992935
Tumor necrosis factor receptor superfamily complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.891
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08689
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935592
mantle zone of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11947
putamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32393
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00816
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01847
mantle zone of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18301
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.89973
Methotrexate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244033
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.49001
SW1573	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43414
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
Schinzel Giedion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32706
BC3C	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54659
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
acquired metabolic disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69955
Omeprazole_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191738
Lung squamous cell carcinoma_LUSC_TCGA-77-6843-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.259
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13486
GTEX-PLZ6-0226-SM-3P61I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887038
hsa-miR-30b	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Ralimetinib dimesylate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0521035
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.26558
PFDN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.234934
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
flupentixol-1288	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49365
TSHZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29259
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
3-acetamidocoumarin-4426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Norepinephrine (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0374366
PA-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K91577886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06008
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2548
A2780	GDSC Cell Line Gene Expression Profiles	1.0	2.67454
Allantoin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0590526
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41077
inherited metabolic disorder	GWASdb SNP-Disease Associations	1.0	0.181004
BRD-K70751829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52634
SNU1076	CCLE Cell Line Gene Expression Profiles	1.0	1.46774
l35	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SN12C	GDSC Cell Line Gene Expression Profiles	-1.0	-2.35193
hydrastine hydrochloride-6011	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Polymyositis	DisGeNET Gene-Disease Associations	1.0	null
Cell junction	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64169
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atazanavir (sulfate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.024805
PRDM16	ChEA Transcription Factor Targets	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20069
BRD-A94366206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49589
BRD-K60337438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93163
AZD1390_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.039694
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Receptor-type tyrosine-protein phosphatases	Reactome Pathways 2024	1.0	null
oxolamine-3344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Topotecan (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0614375
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFE319	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50266
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r2 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2652
flecainide-2557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24373
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50614
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE90754_0_v_1_foxo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K27885839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34189
nadide-2529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ESO51	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUPHD1	CCLE Cell Line Gene Expression Profiles	1.0	1.73197
reciprocal	GeneRIF Biological Term Annotations	1.0	null
eticlopride-4634	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YJ-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carbamazepine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0127922
tanespimycin-432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Loperamide (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0248569
JMSU1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.49072
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99208
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.791213
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03071
HCC2218	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.885993
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.85759
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964636
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66704
regulation of presynapse organization	GO Biological Process Annotations 2025	1.0	null
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18857
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARNT-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7382-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH508	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6792
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.15614
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00561
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
colocalization	GeneRIF Biological Term Annotations	1.0	null
Citalopram (hydrobromide)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0194038
Lung adenocarcinoma_LUAD_TCGA-44-A4SU-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02572
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160246_0_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lansoprazole-6009	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24425
BRD-K01850737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08291
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
methylbenzethonium chloride-3850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lincomycin-2380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61772
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873846
GTEX-X5EB-2526-SM-4E3HY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967217
sulfadimethoxine-7400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ataluren_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0428052
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45695
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976542
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.977575
fulvestrant-7495	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Benproperine (phosphate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017539
Lung adenocarcinoma_LUAD_TCGA-78-7154-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mouse - Motor Cortex - Cross-Species Cluster - Layer 5 glutamatergic neuron, intratelencephalon-projecting_2	HuBMAP Azimuth Cell Type Annotations	1.0	null
propidium iodide-5803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OTX2_KO_GSE27630_51_mouse_brain (fourth ventricular choroid plexus, E13)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tribenoside-6328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
THP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PIK3R4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39259
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10805
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8633
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.985671
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19177
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31227
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K36340167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99027
posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14178
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.8181
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886609
hemicholinium-1601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AMIGO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02157
colecalciferol-6656	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ketotifen-5842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PF-06260933_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0248135
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mouse - Motor Cortex - Cluster - Pvalb+ Il1rapl2+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2787-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.04794
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.89222
pramocaine-2198	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35261
BRD-K88539660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44205
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.980644
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01269
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942616
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.907884
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.831488
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.22047
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41497
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053592
Secondary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21986
Ixazomib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00946533
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.93525
dapsone-1705	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nitrendipine-336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A3KAW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40546
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EI-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00776638
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79164
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
adiphenine-1831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of lipid metabolism	GWASdb SNP-Phenotype Associations	1.0	0.209821
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4286	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lateral part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06319
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45041
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04379
KYSE220	DepMap CRISPR Gene Dependency	1.0	2.45535
NCI-H1838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WYBS-0926-SM-3NM94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24359
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.214
interleukin-1 receptor activity	GO Molecular Function Annotations 2025	1.0	null
nucleotide	GeneRIF Biological Term Annotations	1.0	null
dobutamine-3206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
(+)-chelidonine-5760	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PNU-0293363-6568	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18354
artemisinin-1714	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.81439
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A78236793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06667
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08175
CHAGO-K-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.039339
Psoriatic arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16488
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28425
GTEX-T5JC-2126-SM-32PMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15989
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45136
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OSC19	DepMap CRISPR Gene Dependency	1.0	2.5456
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
foliosidine-3739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46694
BRD-K06834318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11741
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3102
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7909
Flumatinib (mesylate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0253069
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04692
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57295
lysergol-1325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Temuterkib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0497422
SUZ12	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1096
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12337
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0768
SKMM2	DepMap CRISPR Gene Dependency	1.0	2.87017
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4536
Prostate adenocarcinoma_PRAD_TCGA-EJ-5519-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41008930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90981
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
POR_KO_GDS1349_497_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GI-ME-N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49911
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.33805
Brain_CT2_Splat 238	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
Perturb_14497_KD_BCLIN25_SRP326142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
YAPC	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61845
Mouse - Motor Cortex - Subclass - Pvalb+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
Lake et al.Science.Ex5_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
cefsulodin-4148	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HD-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25854
YKG1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.44652
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.645641
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839877
BRD-K72345505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62892
posterior intralaminar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18335
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22603
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08615
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.85231
TP53INP2_OE_GDS5054_385_mouse_Muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919035
ifenprodil-7404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02317
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28797
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6166
liothyronine-3324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nilutamide-5362	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55929
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IE-A4EJ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905097
candidate	GeneRIF Biological Term Annotations	1.0	null
DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	5.27656
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562	BioGPS Cell Line Gene Expression Profiles	1.0	1.324
atracurium besilate-1824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33391
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97675
BRD-K26257310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01439
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19731
PMC8528285-pbio.3001085.s010.xlsx-Fig_8C-MLX_3T3_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
cytokine receptor activity	GO Molecular Function Annotations 2023	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LDB1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01085
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.273104
podophyllotoxin-5841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.873703
norfloxacin-5985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15868
BRD-K13091682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52536
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
CLPP_KO_GSE40207_392_mouse_Testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K16064200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03065
cefotetan-3997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
troglitazone-2692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
upper basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75872
HPAF-II	GDSC Cell Line Gene Expression Profiles	1.0	1.53983
flurbiprofen-5269	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TIG3TD	CCLE Cell Line Gene Expression Profiles	-1.0	-3.07047
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40887
glipizide-6645	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.466172
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8916
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.848423
Primary somatosensory area, upper limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04111
SMC3	ENCODE Transcription Factor Targets	1.0	null
Hepatitis C	DisGeNET Gene-Disease Associations	1.0	null
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HT1376	DepMap CRISPR Gene Dependency	1.0	5.09545
Perturb_1768_KO_Asxl2_SRP124824	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.17065
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11807
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84485
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 6 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08604
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14143
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.664902
circulating	GeneRIF Biological Term Annotations	1.0	null
PNPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68953
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06879
BRD-K55648964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17152
PAQR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21939
YMB1	CCLE Cell Line Gene Expression Profiles	1.0	2.40871
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1355	DepMap CRISPR Gene Dependency	1.0	3.59866
BRD-K51207618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.05331
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.916346
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14079892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40898
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9396374-Table_4.XLSX-AR_related_genes_from_GeneCards-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prestwick-864-3994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41927
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26C-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW1783	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96447
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mephenytoin-6158	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878296
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12846
superficial stratum of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27971
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859101
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	1.42332
Heschl's gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36384
myositis	GeneRIF Biological Term Annotations	1.0	null
Ouabain (Octahydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244017
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
methyldopa-5637	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AG-013608-5909	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKN	DepMap CRISPR Gene Dependency	1.0	7.53919
SC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20B-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3333
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Indolent plasma cell myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
RAD21_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.944106
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0714
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992723
CRCGN013_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31977
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89785
viomycin-2979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16198
biological regulation	GO Biological Process Annotations 2015	1.0	null
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37319
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3828
Hereditary spastic paraplegia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
SNRNP27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24725
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.86004
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953718
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Oxaliplatin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0314151
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11322
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63726
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.854103
Hydroxyfasudil_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0256639
estrone-3071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78372
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_11_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72821236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00669
Tranilast_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00602633
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anchored component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.585
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pelizaeus-merzbacher disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.21695
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27841
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
KYAE1	DepMap CRISPR Gene Dependency	1.0	5.75266
LS123	DepMap CRISPR Gene Dependency	1.0	5.47534
E2F1-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17063
atractyloside-2573	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
prasterone-3097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0974
BRD-K28314528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04574
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61174
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14588
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
naproxen-5457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16791544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35248
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9667
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.10308
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02152
CA46	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80972
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0973
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1179
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal neuron morphology	GWASdb SNP-Phenotype Associations	1.0	0.561769
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6AW-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957403
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11678
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33791
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	2.00662
human immunodeficiency virus infectious disease	GWASdb SNP-Disease Associations	1.0	0.831584
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.902865
NCIH23	CCLE Cell Line Gene CNV Profiles	1.0	1.58471
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-HMGA1_HMGA1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.56337
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.08055
Adagrasib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0376447
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1433
GTEX-RU72-0626-SM-46MUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3192
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08982
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08366
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041546
BRD-K29756429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0732
Fc-epsilon receptor I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87723
H4K20me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01667
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4456
SLR20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57548
Perturb_8646_KO_Fndc5_SRP319261	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.9312
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05011
BRD-K10716948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46168
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Nearest_Ensembl_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
immunodeficiency	GWASdb SNP-Phenotype Associations	1.0	0.726078
Cinacalcet_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0283704
CRCGN015_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44845
cinchonidine-2772	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOLM13	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99250186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26158
Canagliflozin (hemihydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0351886
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0975
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1185
BRD-K89376690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06622
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.80708
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Darolutamide_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0206512
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27185
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47827
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.68352
AHR-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.04823
BRD-K00793226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00921
nordihydroguaiaretic acid-1648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KG-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Meloxicam_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0279362
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69184209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11921
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6954
5666823-609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96839404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09259
ZNF606	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12787
rilmenidine-3133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3VY-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4046
superficial stratum of r5Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17952
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08613
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0617
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.681
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00795
MDAMB435S	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87879
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5903
pentetic acid-5629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55251
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95957
isoflupredone-1832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95419
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876082
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70412800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64576
ERGIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33961
monorden-4443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSK1059615_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244199
PHA-00851261E-3968	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AZD-7648_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0214685
BRD-K72808738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79261
(-)-atenolol-6725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04172
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09711841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10409
TUBB2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2698
PMC11839186-CPR-58-e13756-s004.pdf-30-IKZF2_IKZF2	Rummagene Transcription Factor Associations 2026	1.0	null
MFE296	DepMap CRISPR Gene Dependency	1.0	4.29399
SNU719	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86997
GSE195568_3_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041712
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A89554862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14435
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76437
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76678
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A266-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Robust nucleus of arcopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.283
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.19832
Entorhinal area, medial part, dorsal zone, layer 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78882
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22569
SNU216	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67645
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84589
PL21	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09288
thalidomide-1411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26084
accessory	GeneRIF Biological Term Annotations	1.0	null
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050311
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_01_238	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.76835
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.49001
subthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60767
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6362
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3608
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42693
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58902
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60166659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56984
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.92231
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7933
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.942576
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61213827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8971
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29656
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055254
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47512
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6488-01A-12R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49807
acepromazine-2769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-11A-12R-A26B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GLIPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75746
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.995112
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849172
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05394
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86439
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.86825
interleukin-18 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.92
BRD-K93195567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13274
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT55	Achilles Cell Line Gene Essentiality Profiles	1.0	1.12206
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.866264
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30304
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950223
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4499
OC315	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71
Trimetrexate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0418241
PMC12068594-pgen.1011693.s007.xlsx-MCR_vs_MCW-gene_id_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3854
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068022
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KNS62	CCLE Cell Line Gene CNV Profiles	1.0	1.68909
TP53	ChEA Transcription Factor Targets	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67832115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48345
mexiletine-3862	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lobules IV-V, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20071
NB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60749
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94099
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.95208
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.39965
BRD-K25608271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17414
HCC366	DepMap CRISPR Gene Dependency	1.0	2.95735
PAPA syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23017938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6256
BRD-K08971733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23798
Lung squamous cell carcinoma_LUSC_TCGA-39-5021-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ventilator-associated lung injury_Lung Tissue_GSE2411	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.16057
support	GeneRIF Biological Term Annotations	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00746353
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3714
Entorhinal area, medial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.16372
BEN	CCLE Cell Line Gene CNV Profiles	1.0	1.81985
Harringtonine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00977967
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49004
Lung adenocarcinoma_LUAD_TCGA-J2-8192-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3989
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBGCP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01019
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
lincomycin-5992	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CSTB_KO_GDS5089_565_mouse_cerebellum and granule neurons	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.15191
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4635
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.79132
496100285_TCx_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07793
NR1I2	ChEA Transcription Factor Targets	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19149
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61987
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
PMC11932929-41388_2024_3264_MOESM4_ESM.xlsx-p_0_05_FC_0_5_n_675-Differentially_expressed_genes_in_MCF7_AR-isolated_BCSCs_after_4_days_GSK591_500nM_AR	Rummagene Transcription Factor Associations 2026	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.039149
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863093
cytokine-mediated signaling pathway	GO Biological Process Annotations 2015	1.0	null
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36613
NCIH2009	CCLE Cell Line Gene CNV Profiles	1.0	1.44885
Perturb_12682_KD_miR243p_ERP110145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
virus	GeneRIF Biological Term Annotations	1.0	null
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05805
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32555
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.21724
BRD-K92159000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39934
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05807
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08689
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5288
BRD-K18416855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36245
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
LOVO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37723
BRD-K88385836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14859
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68575551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49123
RAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15126
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5511
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53684
spectinomycin-3327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16611997-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K64632606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65147
nifedipine-603	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
iopromide-2739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A375	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58676
MAZ	ENCODE Transcription Factor Targets	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tinidazole-3896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08881
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3546
PMC11328671-jitc-12-4-s003.pdf-151-IKZF4_IKZF4	Rummagene Transcription Factor Associations 2026	1.0	null
calcium pantothenate-3248	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mouse - Motor Cortex - Cluster - Pvalb+ Gabrg1+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
163 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
metitepine-3231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Immunoglobulin subtype	InterPro Predicted Protein Domain Annotations	1.0	null
Pioglitazone_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0289738
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.042896
Afatinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0264063
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.64109
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924331
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.853126
carbohydrate metabolism disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.791213
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34958
KDM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60425
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11902
BRD-K44422244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14289
Betamethasone dipropionate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.021
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5103
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3-acetylcoumarin-5624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00212
Immunoglobulin-like fold	InterPro Predicted Protein Domain Annotations	1.0	null
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.894005
BRD-K59159285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18403
middle temporal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.87937
CINCA Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
ARNT	ChEA Transcription Factor Targets	1.0	null
droperidol-1290	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61134709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26542
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
alpha-estradiol-4434	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.714
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-0.848987
crucial	GeneRIF Biological Term Annotations	1.0	null
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19319
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08424
Tomivosertib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0406476
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IN-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71842353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00442
BRD-K45525014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00803
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08332
Bestatin (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0361207
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13435
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CWC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33755
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REH	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4452
Ponatinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0391535
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.18815
TP53INP2_OE_GDS5053_312_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Mozavaptan_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145376
BRD-K14799424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31223
bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.104049
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Glasdegib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0231246
PMC4053969-gb-2013-14-7-r81-S3.XLSX-YB1-targeted-genes-gene_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Anastrozole_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0155046
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.18779
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46034
Mouse - Motor Cortex - Cluster - Layer 6 glutamatergic neuron, intratelencephalon-projecting_1	HuBMAP Azimuth Cell Type Annotations	1.0	null
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58775
Prestwick-1085-6131	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
piperacillin-4320	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00829074
NCI-H211	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03414
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13829
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58563
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.851549
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08801
genistein-382	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07639
pralidoxime-3066	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37218
MEL-JUSO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TP53INP2_OE_GDS5054_276_mouse_SKM-Tg - Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54722
Penfluridol_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.022005
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67896
Cloxacillin (sodium)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0563644
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.234934
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.522749
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09193
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2895
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6024
17676974-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19355
bemegride-3389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02382
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15654812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13834
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59571
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.956
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.52567
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857775
PHA-00851261E-3854	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14143
EP300	ENCODE Transcription Factor Targets	1.0	null
vincristine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0175836
interleukin-1 receptor activity	GO Molecular Function Annotations 2015	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.857291
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Altretamine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.011422
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Gene_Name_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RQ-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16149312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09362
SUZ12	ChEA Transcription Factor Targets	1.0	null
debrisoquine-6688	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841024
Ectorhinal area/Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06491
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A20A-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FTC-133	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K89447678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53779
DCBLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63332
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1299	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
terbutaline-1585	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE193027_1_v_0_krt19_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.32812
CAL-120	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46562
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.71738
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.77313
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2112
Zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
azlocillin-2727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8A-MLX_3T3_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of cholesterol metabolism	GWASdb SNP-Phenotype Associations	1.0	0.568635
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.20196
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EK-01A-22R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A54R-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20203758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73885
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8646
Trachea	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.871059
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.875947
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53343
chlorpropamide-5391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCO2	CCLE Cell Line Gene Expression Profiles	1.0	1.54534
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847127
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63285694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78534
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06864
Lung squamous cell carcinoma_LUSC_TCGA-33-4583-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
E2F1-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dabrafenib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0379248
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.853126
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90326
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15484
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5025
intermediate stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36068
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11611
RUNX2	ChEA Transcription Factor Targets	1.0	null
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4495	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
genistein-4459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DDX39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.29206
isosorbide-2183	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
19808871-TableS3	GeneSigDB Published Gene Signatures	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04276
regulation of presynapse assembly	GO Biological Process Annotations 2023	1.0	null
BRD-K76513704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28869
NDUFA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66123
H3K27me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH82	DepMap CRISPR Gene Dependency	1.0	2.03
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963866
BRD-K02299361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23887
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.84694
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.998353
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940237
neurod1_17630985_pineal_gland_lof_mouse_gpl1261_gds3000	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.039779
GTEX-X4EO-0126-SM-3P5YN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1075
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
COLO-783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28512751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55019
Mouse - Motor Cortex - Cluster - Pvalb+ Vipr2+ GABAergic neuron_1	HuBMAP Azimuth Cell Type Annotations	1.0	null
Elimusertib hydrochloride_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0201736
POLR1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1507
vinpocetine-3174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sirolimus-4466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1650	Achilles Cell Line Gene Essentiality Profiles	1.0	1.59869
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K25710391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12631
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.086
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mantle zone of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60132
UMUC14	DepMap CRISPR Gene Dependency	1.0	2.29417
CRCGN015_MCF10A.TP53.M_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23155
BRD-K71197999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02422
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01366
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01071579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65003
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A952-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prestwick-675-2187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84533
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1996
ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ciprofibrate-5740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHU022	DepMap CRISPR Gene Dependency	1.0	2.48284
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5967
LOVO	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93929
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66739
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mimosine-6703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fluvoxamine (maleate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0295866
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.155
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06419
BRD-K60144139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0197
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62384
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40679
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K89459607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08245
Sweat gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
regulation of presynapse assembly	GO Biological Process Annotations 2025	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02577
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIAML5	Achilles Cell Line Gene Essentiality Profiles	1.0	1.80602
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Berbamine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0330324
HSPA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93624
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.951198
dermatomyositis	GeneRIF Biological Term Annotations	1.0	null
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
Methylprednisolone succinate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171921
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.276704
CRCGN015_MCF10A.TP53.M_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30395
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857933
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58423
X-linked adrenal hypoplasia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
H3K9me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.3555
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12755
C-75-6428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
motor neuron atrophy	GWASdb SNP-Phenotype Associations	1.0	0.561769
Inflammation	CTD Gene-Disease Associations	1.0	1.01324
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39861
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.5528
PMC9396374-Table_4.XLSX-AR_related_target_genes-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58180017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12327
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.830885
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71563
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3684
SARS-CoV_12Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.57396
Orbital area, medial part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00694
Sulfatinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.022237
Prestwick-1103-6019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50973
total	GeneRIF Biological Term Annotations	1.0	null
Entorhinal area, medial part, dorsal zone, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95237
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41379
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.73489
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
appendix	HPA Tissue Protein Expression Profiles	1.0	1.6135
RBL1_KO_GDS1932_739_mouse_Neurospheres	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04315
acetylsalicylic acid-2664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14991
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ivabradine (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0161738
chlorpromazine-1822	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
fluoxetine-5356	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63401195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62441
layer 5 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.13818
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64748
analyze	GeneRIF Biological Term Annotations	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043863
Lateral posterior nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85051145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48796
non-syndromic X-linked intellectual disability 63	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cyclosporin A_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0283909
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.56044
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10903
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9-ING-41_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0247244
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
liothyronine-4947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
haloperidol-1203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00835653
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61612
probucol-3223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TET2_KO_GDS4287_429_mouse_LSK - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.72645
BRD-K05432839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13115
UBA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39373
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.89973
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08743
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04673
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	1.417
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18146
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.854164
GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62708
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03718
cSARS Bat SRBD_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.02545
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93264
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.3647
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OC314	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48388
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.124027
Belumosudil_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258771
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2764
sulfachlorpyridazine-6046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r10 part of vagal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12382
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08182
BRD-K56373119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33901
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21056
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HSD17B12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21308
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29935
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.003
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04193
joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.444115
15-delta prostaglandin J2-4455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DEXI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11291
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dermatomyositis	DisGeNET Gene-Disease Associations	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Idiopathic fibrosing alveolitis_Lung Tissue_GSE21369	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.54085
intermediate stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32347
Indacaterol (maleate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0488818
CUL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25297
rolitetracycline-3369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95521279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42294
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
indoprofen-3345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KHM1B	CCLE Cell Line Gene Expression Profiles	1.0	1.36183
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferior temporal gyrus, right, bank of the its	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.824609
layer 3 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18159
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998143
r10 part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02152
NCI-H146	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K76892938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25619
INIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57183
beta-escin-3807	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52081
HCT-116	GDSC Cell Line Gene Expression Profiles	-1.0	-2.01662
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ICC2	DepMap CRISPR Gene Dependency	1.0	2.85062
r5 part of A5 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18335
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.930185
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875024
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864185
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23224
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-24	GDSC Cell Line Gene Expression Profiles	1.0	2.20823
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.85324
PRDM16-22522345-PALATE-MESENCHYMAL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15994
HS172T	CCLE Cell Line Gene Expression Profiles	1.0	2.04727
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.851646
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-692-4424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
healthy	GeneRIF Biological Term Annotations	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.716
haloperidol-5241	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monorden-544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUJ4-1926-SM-4BOOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992266
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7928
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
NCIH1437	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.71822
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44622259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84363
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.53056
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60598
beta-escin-6050	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brivudine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0316644
Medroxyprogesterone acetate_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0485197
Busulfan_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0139511
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
glutamatergic synapse	GO Cellular Component Annotations 2023	1.0	null
ALPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20249
ARFGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0433
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1662
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25705
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25667
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25751
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
icSARS CoV_7Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.86355
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875311
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A8YO-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophagus squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1424
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.041
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02553
BRD-K50272743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07648
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08845
r4 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03652
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tolmetin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237264
CYTH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25375
heptaminol-1825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
diabetes mellitus	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.080593
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40185
RB1_KD_GSE50532_657_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NB69	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1675
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861486
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nomegestrol-5461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.255265
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2874
TEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83316
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055678
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5838
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CLPP_KO_GSE40207_378_mouse_Testies	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Mouse - Motor Cortex - Subclass - Layer 6 glutamatergic neuron, intratelencephalon-projecting	HuBMAP Azimuth Cell Type Annotations	1.0	null
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78994
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.12665
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ranitidine-6324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fedratinib (hydrochloride hydrate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0164099
dorsal periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30758
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1801
TMED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1114
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40025
DDX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21355
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.3137
Hidradenitis suppurativa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
Peretinoin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0341724
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02598
High vocal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3738
intermediate stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49067
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.86825
TE5	DepMap CRISPR Gene Dependency	1.0	2.61672
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4187
Tofacitinib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0148221
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63911
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13637
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23491
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
respiratory system cancer	GWASdb SNP-Disease Associations	1.0	0.241675
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.01814
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KP-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63726
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36624
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10172
Prostate adenocarcinoma_PRAD_TCGA-2A-A8W3-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERK5-IN-2_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029065
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903992
Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39064
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ethaverine-3375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0027
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DHX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3872
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.749
BRD-K65314728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09041
Epirubicin (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0422877
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962855
Becker	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50705
SARS-CoV MA15_Day2-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.79909
WM1552C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28393
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44956
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050047
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4905
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.869889
MAD2L1BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73197
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825591
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01325
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24489
PH-797804_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00925424
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ligands	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8655-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08077
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.345
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902757
vidarabine-2706	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18041
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25214
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12036
pepstatin-4206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ECSCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20773
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A498	GDSC Cell Line Gene Expression Profiles	-1.0	-1.97154
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49348
Lopinavir_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0219842
Glutamatergic synapse	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Ribociclib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0532327
Cytarabine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.039718
Budesonide_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0371755
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
phenindione-5991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69729196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64895
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11629
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850279
central nervous system development	GO Biological Process Annotations 2025	1.0	null
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06754
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04608
Sickle Cell Anemia_Endothelial cell_GSE9877	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.151925
apramycin-4959	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPHB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38134
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6458
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.10412
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.86993
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855417
GTEX-TSE9-2526-SM-4DXUS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17349
SKMEL3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.31763
BRD-K85722065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13445
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4543
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.95237
GOTO	GDSC Cell Line Gene Expression Profiles	-1.0	-2.72122
BRD-K14266419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39796
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QESD-1726-SM-2S1R7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885704
Lung squamous cell carcinoma_LUSC_TCGA-22-5485-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.51919
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02002
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.276425
abnormal motor neuron morphology	GWASdb SNP-Phenotype Associations	1.0	0.561769
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2743
DAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21395
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.78669
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853475
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16165
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25388
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CLPP_KO_GDS4791_537_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SPATA25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7954
cytisine-5739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
metrizamide-4156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K00086692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37101
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.985867
flutamide-3803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.915124
Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A2780	CCLE Cell Line Gene Expression Profiles	1.0	3.4079
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0448
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862424
methanthelinium bromide-6254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K38274933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3312
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0385
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19264
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-7	GDSC Cell Line Gene Expression Profiles	1.0	1.75307
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15936
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.981682
Benztropine (mesylate)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.020629
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
Sulfisoxazole_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204024
BRD-K09511124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71133
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.848423
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01751
sulfamonomethoxine-5843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01278504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25371
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.927463
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.916
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1631
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-HMGA1_HMGA1	Rummagene Transcription Factor Associations 2026	1.0	null
diphemanil metilsulfate-4416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901122
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98913
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74784
nifenazone-2285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86136
GSPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1933
ZNF536	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01664
layer II of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24895
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5470-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05616
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12168
BRD-K85568664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79874
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03709
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNA helicase p68_KD_GDS2152_625_mouse_skeletal muscle cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1928
CTCF_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43N-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
triamcinolone-5835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6515-01A-21R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11835238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20685
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0863
Primary somatosensory area, unassigned	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09088
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977254
Lung squamous cell carcinoma_LUSC_TCGA-18-3419-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.2118
monorden-489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.16855
econazole-6008	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.955203
PMC11825621-210_2024_3353_MOESM2_ESM.xlsx-AR-IL13_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85101781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39426
Human - Motor Cortex - Subclass - Layer 5 glutamatergic neuron, intratelencephalon-projecting	HuBMAP Azimuth Cell Type Annotations	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.884566
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
tonsil	HPA Tissue Protein Expression Profiles	1.0	2.26126
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4EP-2926-SM-3P5YQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2354
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.261135
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PrS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39971
mantle zone of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05646
MEOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51016
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09267
Mouse - Motor Cortex - Cluster - Sst+ Myh8+ GABAergic neuron_1	HuBMAP Azimuth Cell Type Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7029484-13041_2020_561_MOESM3_ESM.xlsx-Table_S8-Table_S8_The_extracted_upregulated_genes_in_SBMA-MNs_in_GSEA_AR	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07226
layer 5 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2652
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911409
phentolamine-3860	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null