association	dataset	threshold value	standardized value
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329407
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332718
WDR62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34628
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259709
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GIPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.29381
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.621
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7606
PMC12532594-41380_2025_3119_MOESM1_ESM.pdf-124-ST18_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BCL2L11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24156
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6301
ZNF681	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18834
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09586
GSE122509,GSE122513_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr3_49843701_A_T_b38	GTEx eQTL 2025	1.0	2.16103
Subcortical volume (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.35229
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF722	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77897
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GLS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.857
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HSPA12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64741
TERB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50559
Ink sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243715
PEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.18664
UBE2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72704
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24688
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207049
APOBEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01279
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04491
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Regular attendance at a religious group	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
Mushroom body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51629
ACLY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37287
MST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34806
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.89
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diagonal band	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69922
496100443_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18585
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35798
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
NAA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27084
CARM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31956
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-f_CEBPA_DEGs-Gene_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
PICALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25798
MRPS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73279
Visual pathway disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
Appendicitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
HNRNPA2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1494
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216764
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
B3GNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59135
KIAA1958	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10464
488395315_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13155
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51995
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
chr3_49733256_CAAA_C_b38	GTEx eQTL 2025	1.0	1.22204
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409314
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228038
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SBK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74028
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250755
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251126
GSE186483_6_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADGRG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79734
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529554
NSDHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02573
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
C1orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52051
MCOLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02961
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.609099
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26646
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76766
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37902
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34464
TNFRSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47733
CNOT6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40383
FAM76A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77645
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
CCDC92B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59613
PRKACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29765
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AJM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3931
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CARD19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49425
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381526
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1714
GPSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53676
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.5238
DSEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63828
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Myosin X complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.581
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.2482
Orofacial cleft	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
GSE165678_0_v_5_stat5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ETFRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39314
GSE190534,GSE190536_0_v_2_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
5216_MRPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525272
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305706
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.46909
SMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32979
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310216
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30604
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31252
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11530610-mmc3.xlsx-WGCNA-GLMP_GLMP	Rummagene Transcription Factor Associations 2026	1.0	null
Vascular endothelial cell_Kidney_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3889
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370798
RNF126	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11025
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235148
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1718_CNOT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676836
BRINP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23236
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.573908
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Embryonic brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344634
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22219
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5830929-supp_gad.301887.117_Supplemental_Table_S3.xlsx-Sheet1-Upregulated_genes_in_CHD7-KD_and_CHARGE_NE_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Stomodeum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
CTHRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39933
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5101
UCHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39361
cofilin-actin rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272784
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2556
GSE239578_1_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310527
PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_3_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
INAVA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80292
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9952
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
FAM83H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58091
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4148
BON-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22154
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SPACA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66914
CLBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67697
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP5IF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35184
MORF4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34164
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20999
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.522833
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Checkpoint clamp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
4379_KIF18A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.563024
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCERG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98092
NAA30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36315
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
p3h3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.482
GSE129389_0_v_1_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61534
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NOS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56104
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3218
SNTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21893
SMG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12404
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	170.777
ERLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34646
CLDN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52242
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain morphology (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100643_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41848
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
PMC5682285-41467_2017_1744_MOESM10_ESM.xlsx-HIFI_KD-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RAB1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37325
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10794847-mmc6.xlsx-PIAS1_KD_down-Table_S5_Genes_differentially_expressed_with_PIAS1_knockdown_in_keratinocytes_cultured_in_the_differentiation_condition_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93969
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08992
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.025
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
Cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.948
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.67268
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35428
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38484
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12958
Female reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.291
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258053
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10632
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264747
Brain morphology (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
Subcortical volume (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
THAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5755
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAX1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57614
MKI67	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72482
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
ATP6V1G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.924
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250013
USP34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90361
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9394
H2AC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.43353
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.483
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36896
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406804
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51607
PMC10042887-41419_2023_5742_MOESM3_ESM.xlsx-Table_S3-Table_S3_Differently_expressed_genes_in_HOXB3_vs_HOXB3-_aPCA_HOXB3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71572
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338005
ZSWIM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46811
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273412
Ski complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRAPPC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04592
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.1228
CEBPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53998
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPPL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21376
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
MRPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27544
LRRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56514
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47385
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
EIF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19318
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHRNA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.13968
GSE132408_0_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dorsal aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
Resting heart rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.25229
DUSP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44206
GSE120413,GSE120447_4_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0187
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
SLC9A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0468
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_3_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VEZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36102
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
Spina bifida occulta	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ktp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
Sleep duration (short sleep)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
FTCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16991
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXRA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72865
Visual cortex disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3088
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0923
GSE195582_2_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11814113-41467_2024_55326_MOESM3_ESM.xlsx-BP_Dorsalgia_GTExQTL_loci_MR-Unnamed_12_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC9A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43844
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
SMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02283
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13269
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244419
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
protein serine/threonine kinase inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dermatofibroma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CSPG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35525
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39062
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301704
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
UBALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17344
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.953131
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YPEL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97337
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243395
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
NPLOC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0869
GIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20674
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
UBAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75721
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PLK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00114
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07648
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368214
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	51.9594
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348328
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510216
SMARCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00083
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10679662-mmc3.xlsx-NC-D5-ZEB2-Mutant-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
496100301_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04155
NPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33108
Gonadal endothelial cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207433_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CKS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22664
MAPKBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37815
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5066615-supp_30.18.2093_Supplemental_Table_S1.xlsx-GR_YBX1_and_HRSP1_down_1_5_fold-Unnamed_1_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
TNRC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84361
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53898
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NPAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45693
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cecal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8857
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	4.02804
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC25A25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32742
PMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47788
LIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5124
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMIM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84562
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cleft lip	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ciliary basal body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LF-64-NB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218097
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252505
ANAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33777
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02702
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9758
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89471
Perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE122509,GSE122513_2_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FGFR1HighNME5- epithelial cell_Esophagus_Human	CellMarker Gene-Cell Type Associations	1.0	null
ARL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21367
GSE128634,GSE128636_4_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COL6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23742
DHX29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.035
CEND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16079
AP1M2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33418
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D4_vs_D9-Unnamed_2_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
RPL37A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39447
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249335
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227655
Auditory vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
SAP130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63651
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.4906
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11854
GSE63857_3_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11233907-mmc8.xlsx-S7-Table_S7_Heterogeneity_Analysis_and_Egger_Intercept_Test_for_MR_Hits_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ONECUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15673
MAGEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62614
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4293
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14782
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1053
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TSACC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00556
FOXR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82707
protein kinase binding	GO Molecular Function Annotations 2025	1.0	null
HEXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34221
ADGRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65428
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.71
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.8389
MOCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17672
CENPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12943
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-13_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HTRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22748
KIAA0930	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53746
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1772
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58072
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
FSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10141
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3245
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZC3H13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48752
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-441-BPTF_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09075
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3536
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100548_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25576
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
968_C12ORF60_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.740488
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endometriosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.291
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214938
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_16_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.877
GSE182840,GSE182844_0_v_1_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC16A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11489
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162688_1_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.558978
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-123-HOXC11_HOXC11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3475
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
C3orf14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34945
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF830	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07425
PMC5682285-41467_2017_1744_MOESM10_ESM.xlsx-H9_KD-Supplementary_Data_7_qPCR_analysis_in_independent_hESC_lines_and_iPSCs_of_potential_CSDE1-regulated_transcripts_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF330	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13858
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30584
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225411
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80192
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.78902
PITPNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79533
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50441
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40946
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TNNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.369
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PSMD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19927
PPP2R5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31976
ZNF157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19486
SLC30A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68092
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.89
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.8536
GSE114992,GSE114993_0_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03318
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40088
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HS2ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37572
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.89
PMC11055867-41598_2024_60205_MOESM1_ESM.pdf-12-POU2AF1_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cortical blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	2.94672
TCEAL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48807
Branchial arch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.34
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MT1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96869
UBE2Q2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10969
GSE195513_2_v_1_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2346
SLC37A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06919
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.58813
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291463
7193_RBX1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565991
BE-85-CH49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216867
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202878
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7951
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326977
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8147
GSE168807_6_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMIM10L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75357
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33848
APBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25344
EIF3I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28445
DPPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54405
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComDown-List-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Giant cell tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
PMC4595011-pgen.1005555.s001.xlsx-MITF_DOWN-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319263
ERV3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34765
Conjunctival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
AHCTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85097
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PGAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7623
Glycine encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
TRAPPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45967
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02985
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348896
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06107
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346557
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.789
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cortical surface area (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.6
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3116
GSE148066,GSE157787_11_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54547
SURF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24453
EIF3J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93671
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18301
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.925817
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NUF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43648
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Anterior cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.554
Actin rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
DCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3712
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76736
PMC11003700-pbio.3002240.s011.xlsx-MYCN-IMR32_RawData-Unnamed_2_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.963
GSE188814,GSE188854_0_v_1_wtap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202744_1_v_0_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265267
COIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22247
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241741
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51432
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHST14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80115
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1554
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27642
FHIP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78621
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SRPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0583
ZCCHC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12693
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336111
STPG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34609
GFOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21385
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75654
GSE161295_2_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ABCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73351
PMC5682285-41467_2017_1744_MOESM10_ESM.xlsx-HUES9_KD-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
QARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09249
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
ZNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23469
NRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11434
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDCD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25391
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
PRPF38A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69121
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255983
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ROMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00539
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.417273
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBB4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32027
ZBTB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65514
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-geneName_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15069
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304999
DDX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4417
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307279
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99633
TIPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45584
PIGW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33821
GSE96641_3_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Foregut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Refractive error	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.33979
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28329
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.877
chr3_49813942_C_CCTGGCTCCT_b38	GTEx eQTL 2025	1.0	3.70273
MGAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03324
ATP6V0A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07681
Woronin body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.089
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
HIP1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42094
GSE100316_3_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
2394_DTYMK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50382
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229457
ARSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90967
Blastema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLDIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17043
SPHK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77761
PIK3CD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24736
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Extremely high intelligence	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3448
RNA polymerase I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.029
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221572
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF221	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06676
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1963
MYOZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39956
TMEM80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2523
PINX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49909
UQCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65274
ZNF138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06558
kinase binding	GO Molecular Function Annotations 2025	1.0	null
SHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18816
MCM3AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32819
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NRSN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07431
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.467
SRP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41333
EGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16023
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1468
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228897
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TPMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65066
RDH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04844
Neural tube defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
t30-blood-rna_female_2w	MoTrPAC Rat Endurance Exercise Training	-1.0	-16.0665
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2353
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89385
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DOCK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41912
GSE207787_3_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1182
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.966415
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80281
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.626587
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PRR14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36342
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.2045
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1726
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6226
KRT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99671
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90065
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2181
PHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49455
CEP41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.75812
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7153
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
STRA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8907
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.585457
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4598
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
KLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00249
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Neural crest	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.509
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.539
VAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26953
FAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16356
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322107
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
X-linked cleft palate with or without ankyloglossia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344523
CORO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65492
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00805
DEXI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34403
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239578_2_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Auditory capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
Podosome ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.952
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29907
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5206
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.353111
TTT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60126
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6497
LRFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42546
SRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67064
DEF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.17436
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5281
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr3_49660026_G_A_b38	GTEx eQTL 2025	1.0	3.42113
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47899
GSE129772_2_v_1_runx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8204
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5739
GPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51162
GNG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67833
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65861
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.360277
Omasum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82427
GSE148066,GSE157787_9_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4996
TPD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01025
HLCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39011
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr3_49706959_A_G_b38	GTEx eQTL 2025	1.0	2.25666
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5738693-12944_2017_641_MOESM2_ESM.xls-FPP_vs_Control-Unnamed_2_MSX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02571
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.3214
DPAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67792
AIFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61421
PURB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13892
PMC7780220-12943_2020_1301_MOESM8_ESM.xlsx-Fig_3A_RNA-seq_DEGs-Summary_701_LPS-induced_DEGs_361_THZ1-sensitive_DEGs_in_blue_of_macrophages_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TBC1D2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50245
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10868
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20286
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3823
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-57-FX61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207917
TXNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78441
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20684
PALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15885
KBTBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18079
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
WDR46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42635
BARX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39229
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307866
PPP1R10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44004
2218_DHX9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518972
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
H-NS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.509
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.1657
PDIA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40177
IGF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66289
Regular attendance at a gym or sports club	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.922185
PMC5682285-41467_2017_1744_MOESM10_ESM.xlsx-H1_KD-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.6129
GSE179974_3_v_2_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316682
CGRRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46966
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	4.07759
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214514_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CREB3L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20704
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90708
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
HUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28316
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30795
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27655
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
COLGALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45207
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24012
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MSMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36099
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332706
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PARP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23988
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24892
PDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18302
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27728
LRP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22642
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68677
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0593
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86021_1_v_2_crenolanib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Fibrillar center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
PMC11112608-BLOODA_ADV-2023-011512-mmc1.pdf-24-ZNF471_ZNF471	Rummagene Transcription Factor Associations 2026	1.0	null
TEKT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92586
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25185
SOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10088
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44948
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.57475
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3596
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9278
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77711
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327824
TXNL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33368
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17251
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AHSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19065
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89009
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
WFDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54207
SULT1C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26308
PMC6879454-Data_Sheet_1.xlsx-AA_in_vitro-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2134
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.877
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228413_2_v_5_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF468	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07854
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42455
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.595152
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.6271
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pseudopalisading cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
ANXA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79556
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
1779_COPS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529739
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78593
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39044
ERBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02293
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11233907-mmc9.xlsx-S8-Table_S8_Colocalization_Analysis_for_MR_TWAS_PWAS_Hits_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234375
NODAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37006
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214823,GSE214824_5_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2496
CEP152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09932
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
FARSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34618
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein kinase inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.9737
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4966
KCNJ14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36285
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100328_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4951
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212158
GSE114992,GSE114993_1_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.892
USF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07231
7830_SF3A1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566471
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262309
ORC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95604
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.7087
ADAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21504
GTEx Thyroid 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-7.25271
FGF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17104
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PSMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5378
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02099
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5933
PMC11769988-Table1.xlsx-Table_S3-Table_S3_SCLC-related_genes_screened_by_MR_analyses_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
JMJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46376
MAPK8IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51938
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64987
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
CD164L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19222
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Magnetosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
MTERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04907
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92785
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294702
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.39032
GUF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23247
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345548
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.570959
ZNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1985
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MLLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45238
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02395
MAP3K20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14885
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.623657
DSTYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23083
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.403
GSE184892_0_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298478
PMC8390644-41467_2021_25107_MOESM6_ESM.xlsx-Primed_BRG1-KD_significant-gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6595
Neural ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45642
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252153
External ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.759
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13474
CLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37319
PCCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75697
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2921
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
PTEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0611
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE126219_0_v_1_haloperidol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358583
chr3_49820709_A_G_b38	GTEx eQTL 2025	1.0	5.1469
GSE224131_5_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AGAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57787
TCFL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15668
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8138
ZCCHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18982
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386394
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOMO-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.117
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27937
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7812
TMEM218	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82939
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.567097
Hi-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44625
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5886
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Isolated cleft palate	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
BECN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03728
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54147
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243512
AHSA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03836
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-1_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TSPAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3502
KPNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42233
DNAJB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46201
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WSU-DLCL2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
IDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03611
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Limb bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945