association	dataset	threshold value	standardized value
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.4277
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	328.661
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160773
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166823
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.4918
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196046
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5384
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264314
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00042
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149123,GSE149128_1_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55372
DHX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60956
GSE195786_3_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.2971
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.82
PMC12141477-41467_2025_60329_MOESM3_ESM.xlsx-log2FC_0_5_cut_off_-_258_genes-Supplementary_Data_1_Genes_identified_by_both_HLF_overexpression_OE_and_knockout_KO_RNAseq_HLF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0451
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21961
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160203
TMEM138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4024
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12439337-thnov15p9091s1.pdf-45-ENSG00000126561_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163931
PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_AsPC1-Nearest_Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240974
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213285
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
MCF7_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014199
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244253
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156017
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143643
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0420518
MCF7_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247702
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39191
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174378
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
chr8_143782454_GCTTA_G_b38	GTEx eQTL 2025	1.0	3.1007
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	158.474
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0374359
MCM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2945
MCF7_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019699
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121558
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148938
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6938
MCF7_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013832
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5315
MCF7_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142535
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.283
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121127
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00884069
MCF7_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016484
CCT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29895
HAPLN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39119
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2725
PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200242
MCF7_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170231
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00966577
MCF7_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156014
MCF7_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135345
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224078
MCF7_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205118
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203398
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.1822
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195803
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15035
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
QSOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00756
USP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10131
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106553
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NA-16-OJ70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210111
TBCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00732
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247405
RABGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17127
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.5899
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019221
SGPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13297
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174114
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04491
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4886
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019544
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.6136
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261061
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00762931
PPP4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05833
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9838
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014335
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338816
TUBB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39733
MCF7_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211672
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015932
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144254
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.65242
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2236
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4838
GSE201309_4_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260716
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015713
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213799
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10205
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126403
MNAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46833
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154471
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
FHIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58085
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
ZFTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1749
MCF7_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135156
CSNK1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71227
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138544
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021118
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.536
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL27A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48735
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369795
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.746
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224557
PMC8500868-401_2021_2354_MOESM5_ESM.xlsx-GEP_PATZ1-Gene_Symbol_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.4232
MCF7_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232441
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163041
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136483
TRAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19229
MCF7_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193707
GDAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57156
MCF7_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146763
MCM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8136
PMC12611713-Table2.xlsx-Sheet_1-Training_Database_AND_Validation_Database_NOT_Diabetes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217685_0_v_1_ddx20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146473
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136504
TSACC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87852
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.8808
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210438
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12036091-jcav16p2321s1.pdf-10-E2F7_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
SMARCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52744
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	279.54
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178113
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0291413
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161698
MCF7_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270861
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212597
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203564
MCF7_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181689
GSE227698_5_v_3_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119799
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176811
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206099
GSE202587_1_v_2_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179754
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.15
PKMYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19857
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
496100506_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35052
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01934
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.8213
PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253299
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0422086
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132635
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2446
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
EEF1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55667
PMC9950457-mmc3.xlsx-GRHL2_overexpression_UP-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159936
MCF7_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016793
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
496100296_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0895
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	280.722
ACADS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1357
496100553_TCx_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14324
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118935
PHLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8616
MCF7_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142956
MCF7_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244572
SMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10205
CD99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0021
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72383
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
FADS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35032
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128612
MCF7_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179321
CACTIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8044
CLASRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03296
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180449
MCF7_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223738
ATP1B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28595
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47461
GNG12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48745
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166228
NT5DC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67042
MCF7_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137458
MCF7_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238637
Laryngeal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9753
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	178.627
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.32703
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00819661
STOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64024
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	199.613
ARMCX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22124
PABPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15096
PMC10273062-JCMM-27-1708-s001.xlsx-Sheet_1-CESC_AND_UCS_NOT_BRCA_NOT_UCEC_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
MAPK14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08297
MANSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21238
MCF7_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134128
MCF7_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150754
496100411_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00611
MCF7_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144897
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.665
PMC11455910-18_2024_5418_MOESM1_ESM.xlsx-Table_S2-Table_S2_DEGs_identified_in_PC3_cells_with_METTL3-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CPSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92679
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05104
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30892
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170717
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.253
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38868
MCF7_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163394
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6762
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65502
KANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37854
MCF7_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170724
SEC23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.183
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017498
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
RNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11565
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9148
MAP6D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4331
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148675
MCF7_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152213
ZNF789	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09225
MCF7_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262652
MCF7_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339417
MCF7_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148477
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150651
MCF7_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012679
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12304111-41598_2025_13196_MOESM5_ESM.xlsx-Sheet_1-Table_S4_DEGs_Log2FC_1_and_p_adj_0_05_in_pancreatic_cancer_with_high_versus_low_OVOL1_expression_OVOL1	Rummagene Transcription Factor Associations 2026	1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5571
BD-46-RY02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207874
PMPCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13779
MCF7_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123937
MCF7_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106058
BF-10-IO69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241468
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198877
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208568
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165793
ASNSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18496
MCF7_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197094
TDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34807
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.5
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.37164
496100522_PCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90396
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC25A28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05019
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5322
MCF7_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117659
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169469
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021403
TMEM178A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22374
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213864
MCF7_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255621
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172084
MCF7_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269906
MCF7_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193746
LMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5239
MCF7_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218211
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155166
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028547
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.9905
Hypertrophy of breast	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265619
XRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21413
MCF7_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322947
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187551
SRSF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06966
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.974
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.8653
PPP1R37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08853
MCF7_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191749
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.3878
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242124
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2896
PDXP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48692
MCF7_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016195
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260758
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.3873
POGZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17889
MCF7_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116204
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279472
Gallbladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11661
GSE129648,GSE129650_2_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49539
ACY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72256
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39615
MCF7_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019295
MCF7_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015296
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253078
MCF7_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250657
RAVER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03953
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149118
AD-18-XC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251973
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	192.019
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213575
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6012
MCF7_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0299401
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112068
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016495
TMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07268
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01679
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-639-ENSG00000181135_ZNF707	Rummagene Transcription Factor Associations 2026	1.0	null
SYT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05527
NOP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81349
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.504
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162518
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
BAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09175
496100464_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20227
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103771
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144212
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1773
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.8359
NDUFS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18255
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164611
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4181
ZNHIT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61802
MCF7_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141324
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128839
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9402
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151549
Rumen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
MCF7_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017012
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00800193
POGK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28148
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217374
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0333936
496100369_PCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16959
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49704
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42018
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39373
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193446
ARSI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42989
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	3.23293
GSE166004_1_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180085
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0815
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194798
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	181.286
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91927
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35141
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9261
DUSP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0514
DYNLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62798
MCF7_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148598
OTUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16193
SARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12177
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147199
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0373
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024995
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LHFPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24608
PMC12003195-41591_2024_3486_MOESM1_ESM.pdf-12-ZNF8_ZNF8	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243066
HIVEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33195
MCF7_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136526
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151535
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176475
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165485
MCF7_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00870609
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103208
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6545
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	188.881
MCF7_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127234
MCF7_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028667
PMC7899452-media-3.xlsx-Early_Resp_FOXJ1_high_Ciliated-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12784616-12711_2025_1028_MOESM2_ESM.xlsx-TableS7-Table_S7_Summary_of_significant_MR_associations_in_milk_cells_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1718
MCF7_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218368
MCF7_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173953
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04597
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146208
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4132
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.643
MAK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3498
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267157
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	2.42651
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2497
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2IRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19887
MCF7_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188664
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201579
ZW10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70562
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.34711
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229932
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0827
MCF7_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020455
MCF7_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00933888
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55251
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.966
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0295482
CINP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22656
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163766
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4167
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124549
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2039
MCF7_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165753
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	181.16
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139401
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	4.75747
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	194.826
MCF7_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165066
MCF7_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154395
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198385
DEXI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55275
MCF7_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142358
SERINC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.783
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.1841
MCF7_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015256
MCF7_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160992
ARMC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22838
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8895
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9052
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204422
MCF7_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136029
MCF7_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187433
MCF7_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179785
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178362
HSPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22772
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253218
MCF7_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133642
NCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09097
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-Unnamed_0_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19708
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20942
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	250.547
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01048
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.8999
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177116
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.18
496100502_TCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.10837
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165803
MCF7_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240782
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31976
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79239
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130783
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152301
MED23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24257
MCF7_Fedratinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019217
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Epothilone A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132009
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022248
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220416
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171182
Dopaminergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.928
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59593
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1255
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	187.634
MCF7_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00992081
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.187
ZNF396	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01355
PFDN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03831
NSMAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02454
MCF7_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162972
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	170.481
HESX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20554
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311894
MCF7_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011675
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244789
RAB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18175
MCF7_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00912018
MCF7_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179315
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176016
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00837655
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3015
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35045
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.8313
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118981
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9463
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6621
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	148.063
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11551338-pnas.2411189121.sd01.xlsx-FXR-Unnamed_0_NR1H4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5157
NAPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63197
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6794
MCF7_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210549
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23109
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155538
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133793
GB-94-XG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30893
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	203.818
ARNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29691
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313388
MCF7_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187263
MCF7_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244911
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00775243
Laryngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
IMPACT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05588
GSE215132_1_v_0_ptpn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141977
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163733
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.3922
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207279
SPART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16535
MCF7_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128737
HNRNPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46484
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	213.386
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE243491_3_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PCNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04796
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211809
LINGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18619
TRIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17109
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259084
MCF7_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236862
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177724
MCF7_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214271
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00977437
MCF7_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147683
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019477
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012697
MCF7_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153264
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165553
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-FOXM1_targets_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10614035-2022_281869_LUTGE_SUPPL_TABLES4.xlsx-TP53-ID_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31374
RBM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41644
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6136
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.5022
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-190-ZNF707_ZNF707	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5408
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1772
SRSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07503
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266346
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26345
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.7246
MCF7_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141711
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253949
GSE215132_2_v_0_ptpn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142602
MCF7_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235762
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28329
MCF7_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0331446
HAPLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96248
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.8403
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.5933
RAB5IF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84417
EXOSC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88177
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.4138
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339349
TBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09733
SSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35268
MCF7_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177662
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136408
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.9582
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.801
MCF7_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136113
MCF7_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149245
ACTR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09718
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232813
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219166
MYBPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04709
ZNF581	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31984
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.623
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.7526
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251529
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46929
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275613
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189389
GSE103297_1_v_0_glis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5878
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143977
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.7675
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2687
MCF7_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227885
MCF7_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185266
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139825
CHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35015
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.809
PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8384902-mmc6.xlsx-DEG_3TF_KD_unique-GeneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126601
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50997
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.2853
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012695
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210026
ZC3H18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29818
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167403
496100530_FWM_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.02692
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8006
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	140.059
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.6601
MCF7_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296898
MCF7_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013238
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0333
MCF7_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148992
CDK18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15013
MCF7_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182768
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	177.23
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70558
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245812
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.8956
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DISP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35136
MCF7_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189377
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135122
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152199
PMC8299217-mmc2.xlsx-Early_Resp_FOXJ1_high_Ciliated-Unnamed_6_FOXJ1	Rummagene Transcription Factor Associations 2026	1.0	null
ECSIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66036
MCF7_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176385
chr8_143755160_G_C_b38	GTEx eQTL 2025	1.0	1.85207
RPL36AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13696
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01974
PABIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12978
MCF7_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157312
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	261.088
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127712
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154386
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3934
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SEMA4G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26457
MSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26049
WEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31799
MCF7_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129045
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10644
MCF7_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172195
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4399
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195141
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9151
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.475
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152909
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.2402
PSMD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05593
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208042
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6042