association	dataset	threshold value	standardized value
interleukin1	GeneRIF Biological Term Annotations	1.0	null
Proteinuria	CTD Gene-Disease Associations	1.0	1.31208
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7822
hsa-miR-4731-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
cellular response to stimulus	GO Biological Process Annotations 2015	1.0	null
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_baboon_DRSG_lowerRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_5_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Meloxicam_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00714143
PMC6959184__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC5101451__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Medroxyprogesterone acetate_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0281423
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303365
revealed	GeneRIF Biological Term Annotations	1.0	null
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.702
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X5EB-1026-SM-46MVU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46736
TAK1-dependent IKK and NF-kappa-B activation	Reactome Pathways 2024	1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of digit	GWASdb SNP-Phenotype Associations	1.0	0.60143
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.68912
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
Goserelin (acetate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246361
immune response-activating signal transduction	GO Biological Process Annotations 2015	1.0	null
CDK5RAP3	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-1626-SM-48FF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27972
Perturb_9144_KD_METTL3_SRP280216	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
YTHDC2	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_14832_KD_Scr_SRP017110	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55121
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.455156
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.186397
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37084
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07517
hsa-miR-4700-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pitavastatin (Calcium)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274903
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229009
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71999
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933276
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.951
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the radius	GWASdb SNP-Phenotype Associations	1.0	0.60143
fibroblast-like synoviocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
NB(TU)1-10	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.93705
PMC3672773__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE173873_1_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052588
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.083524
Rhinovirus Infection	DisGeNET Gene-Disease Associations	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04791
regulation of map kinase activity	GO Biological Process Annotations 2015	1.0	null
abnormal innate immunity	MPO Gene-Phenotype Associations	1.0	null
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883198
Activin AB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
TM9SF1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3547332__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Reactome Pathways 2024	1.0	null
hsa-miR-521	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4EGI-1_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0112398
KCL22	CCLE Cell Line Gene Mutation Profiles	1.0	null
MK-8353_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245711
ATF3	ChEA Transcription Factor Targets	1.0	null
GSE123887,GSE123888_3_v_4_hpgd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11461876-42003_2024_6975_MOESM5_ESM.xlsx-Supplementary_Data_3-Supplementary_Data_3_Differentially_Expressed_Genes_HSE_THP1_UV_Vs_HSE_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Acute Myeloid Leukemia_LAML_TCGA-AB-2991-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BAG3	Pathway Commons Protein-Protein Interactions	1.0	null
NOD1/2 Signaling Pathway	Reactome Pathways 2014	1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PELI2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of long bone morphology	GWASdb SNP-Phenotype Associations	1.0	0.60143
16760443-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PMC4369672__F1	PFOCR Pathway Figure Associations 2023	1.0	null
leukemia	GWASdb SNP-Disease Associations	1.0	0.794591
hsa-miR-520e	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
PMC5343938__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84181
interleukin-4 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.703
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.566844
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JQ1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124237
Sarcoma_SARC_TCGA-SI-A71O-06A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3428-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC5390115-mmc7.xlsx-DE_Lists-H1-ECs_Experiment_2_H1-EC2_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01304
hsa-miR-520f	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
positive regulation of map kinase activity	GO Biological Process Annotations 2015	1.0	null
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A5DR-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5039188__F1	PFOCR Pathway Figure Associations 2024	1.0	null
innate immune response-activating signal transduction	GO Biological Process Annotations 2015	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mouse	GeneRIF Biological Term Annotations	1.0	null
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.36648
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.183894
GSE173873_2_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9735758__F3	PFOCR Pathway Figure Associations 2024	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055222
mRNA_KLF4_18264089	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13427
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	Reactome Pathways 2014	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Toll Like Receptor 4 (TLR4) Cascade	Reactome Pathways 2014	1.0	null
CDC37	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09284
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13921
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.22534
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26767
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.268237
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
AA-58-FJ71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430238
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	1.0	3.03613
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897044
FOLH1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41848
MYD88	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182807
PMC7481169-277_2020_4194_MOESM9_ESM.xlsx-RUNX1_R139G-RUNX1_R139_mutant_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
MZ in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71249
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02422
VZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89061
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8466
GTEX-T5JC-1826-SM-4DM6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0482
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839115
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
toll-like receptor 5 signaling pathway	GO Biological Process Annotations 2015	1.0	null
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitoxantrone (dihydrochloride)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206635
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QESD-0626-SM-2I5G4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20517
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13239
PMC3594740__F1	PFOCR Pathway Figure Associations 2023	1.0	null
regulation of nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
intervention	GeneRIF Biological Term Annotations	1.0	null
Eye Diseases	CTD Gene-Disease Associations	1.0	1.41257
Rupatadine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
Histiocytic lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
DT-061_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0606318
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33617
Belzutifan_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024951
olaparib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0420509
ZEB1	ENCODE Transcription Factor Targets	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
Thymol_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0324523
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUZC-0326-SM-4BOO8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07743
Lung adenocarcinoma_LUAD_TCGA-69-7974-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02299
GSE166944_1_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03667
Enteric muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79569
MEC1	DepMap CRISPR Gene Dependency	1.0	2.70219
PMC3923659__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Meningioma	HuGE Navigator Gene-Phenotype Associations	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137914_0_v_5_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of immune system process	GO Biological Process Annotations 2015	1.0	null
RERF-GC-1B	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135703
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
PMC4668848__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NDUFB4	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03764
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
Respiratory allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
PMC6527596__F1	PFOCR Pathway Figure Associations 2023	1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3322338__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC3743959__F1	PFOCR Pathway Figure Associations 2024	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45876
Diabetes Mellitus, Type 2	CTD Gene-Disease Associations	1.0	1.03122
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.854814
PMC3085878__F3	PFOCR Pathway Figure Associations 2024	1.0	null
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12714
urethral sphincter sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC2721684__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC10643282-mmc1.xlsx-diff_genes-RELA_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.07731
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE89032,GSE89033_0_v_1_sfpq_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.18159
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.785
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8639061-pcbi.1009563.s014.xlsx-ST4-S4_Table_Phenotypic_master_regulator_MR_list_with_pleiotropy_count_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HSC3	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26682
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bergenin_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266514
testis_7d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.850405
OCI-M1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X4XY-1026-SM-46MVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22365
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233119
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5570_KO_NFKBIA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.91594
GD-98-WZ24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227506
PMC3890654__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Toll Like Receptor 9 (TLR9) Cascade	Reactome Pathways 2014	1.0	null
Aliskiren_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0272156
PMC6781720__F1	PFOCR Pathway Figure Associations 2024	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295668
PMC2168342__F7	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-S32W-2026-SM-4AD6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972349
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LY2090314_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120284
PMC7883590__F2	PFOCR Pathway Figure Associations 2024	1.0	null
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
collagen disease	GWASdb SNP-Disease Associations	1.0	0.375297
Vilanterol_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0308147
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.863789
Balsalazide (sodium hydrate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0193677
GTEX-XUZC-1226-SM-4BRVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973796
NCIH747	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58372
KASUMI1	DepMap CRISPR Gene Dependency	1.0	3.06608
Larotrectinib sulfate_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0207149
PMC8033157__F1	PFOCR Pathway Figure Associations 2023	1.0	null
HS766T	CCLE Cell Line Gene Expression Profiles	1.0	1.48008
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05377
Tomivosertib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282734
abnormal circulating protein level	MPO Gene-Phenotype Associations	1.0	null
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0259015
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Trifluridine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0316143
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.31716
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15021
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EF-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Toll Like Receptor 2 (TLR2) Cascade	Reactome Pathways 2014	1.0	null
supramarginal gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.68849
GSE246195,GSE246305_4_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2668232__F5	PFOCR Pathway Figure Associations 2023	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30084
GTEX-S7SF-1826-SM-3K2AD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58273
Death-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28618
protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059176
PMC4002811__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Acetohexamide_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.023384
GSE209698_0_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0296129
Seizures	CTD Gene-Disease Associations	1.0	1.49967
LAMTOR1	Pathway Commons Protein-Protein Interactions	1.0	null
Docetaxel_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234341
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_38_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13067
abnormality of the middle ear ossicles	GWASdb SNP-Phenotype Associations	1.0	0.60143
HRAS	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-VT-A80J-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053433
negative regulation of DNA-binding transcription factor activity	GO Biological Process Annotations 2023	1.0	null
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4957230__F4	PFOCR Pathway Figure Associations 2024	1.0	null
fanconi's anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.306672
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41309
testis_7e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.835219
PMC9191825__F4	PFOCR Pathway Figure Associations 2024	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
A549_JNJ-7706621_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172687
PMC3470785-NIHMS377161-supplement-14.pdf-416-KCNIP3_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.543359
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36777
hsa-miR-320d	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
CTCF	ChEA Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.51927
oligomer	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7213-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37917
Temsirolimus_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0137773
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.05301
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6307204__F5	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16783
GSE130437_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.070191
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987604
hsa-miR-4252	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC1999_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0285788
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894031
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
NG25_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0150719
RNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.626
RB1_KD_GSE50532_627_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MYC_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.7535
PMC3552145__F10	PFOCR Pathway Figure Associations 2023	1.0	null
PMC3208682__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5557-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-134-HOXC12_HOXC12	Rummagene Transcription Factor Associations 2026	1.0	null
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48339
hsa-miR-548c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vicriviroc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.49
helical	GeneRIF Biological Term Annotations	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960005
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5200-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4391941-ppat.1004737.s013.pdf-2-SOX6_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-520c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Benztropine (mesylate)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0157512
nucleus	GO Cellular Component Annotations 2025	1.0	null
icSARA deltaORF6_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.3741
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A6YT-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5977009__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HIV Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lipopolysaccharide receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.555
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JVM3	DepMap CRISPR Gene Dependency	1.0	2.19759
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.879523
PMC6966713__F5	PFOCR Pathway Figure Associations 2023	1.0	null
IRAK4	Pathway Commons Protein-Protein Interactions	1.0	null
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.910201
SNU324	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68312
Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.948701
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
Ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24549
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341982
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38205
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	1.0	2.3964
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.53383
abnormality of limb bone	GWASdb SNP-Phenotype Associations	1.0	0.449679
E2F4	ENCODE Transcription Factor Targets	1.0	null
PMC4002811__F2	PFOCR Pathway Figure Associations 2023	1.0	null
alzheimer	GeneRIF Biological Term Annotations	1.0	null
PMC5415836__F2	PFOCR Pathway Figure Associations 2023	1.0	null
colorectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.264011
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_689_KO_CD5L_ERP111466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Cystitis	CTD Gene-Disease Associations	1.0	1.49992
bladder	GTEx Tissue Gene Expression Profiles	1.0	1.38408
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal Diseases	CTD Gene-Disease Associations	1.0	1.02858
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
b220.bcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47564
GSE168797_4_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CMT-93 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
Tofacitinib (citrate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0285236
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.879428
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20192
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC3136902__F1	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059297
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
P68467	Virus MINT Protein-Viral Protein Interactions	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941925
PMC3137974__F1	PFOCR Pathway Figure Associations 2024	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.627889
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q0-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_3_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTNNB1	ChEA Transcription Factor Targets	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
VDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
E2F6	ENCODE Transcription Factor Targets	1.0	null
bewo	HPA Cell Line Gene Expression Profiles	1.0	1.19001
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19218
GSE160246_9_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carboplatin_homo sapiens_gpl570_gse13525	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059781
abnormality of the nephron	GWASdb SNP-Phenotype Associations	1.0	0.409473
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21863
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.635403
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tubulin inhibitor 6_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0372749
Interleukin-1 family signaling	Reactome Pathways 2024	1.0	null
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21724
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Methylthiouracil_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.031655
GSE190186,GSE190188_0_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2573957__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Transforming growth factor beta activated kinase 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.4
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
17683608-TableS5	GeneSigDB Published Gene Signatures	1.0	null
PMC8033157__F1	PFOCR Pathway Figure Associations 2024	1.0	null
abnormal circulating interleukin level	MPO Gene-Phenotype Associations	1.0	null
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18804
membrane part	GO Cellular Component Annotations 2015	1.0	null
PMC9321586__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6093-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vaginal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865942
Legionellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Celecoxib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0121952
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838804
Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLIK (SAGA-like) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.731
lamp1	GeneRIF Biological Term Annotations	1.0	null
GSE233112_2_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the upper limb	GWASdb SNP-Phenotype Associations	1.0	0.498138
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
receptor complex	GO Cellular Component Annotations 2015	1.0	null
Varespladib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
FOXO1_01_321	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.80965
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11349
PMC7764362__F2	PFOCR Pathway Figure Associations 2024	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.946247
mewo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.616586
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.423054
Perturb_11667_KD_PTBP1_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.44052
PMC8625721__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
COP9 signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.728
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.947959
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196962_4_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112762,GSE112767_1_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.21148
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254155_5_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2025	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.945
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.851906
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13918
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.361155
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8827
Dexrazoxane	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.63
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40444
CTCF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pioglitazone_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250335
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17644
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085319
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
Autoimmune disease of gastrointestinal tract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
Carcinoma	CTD Gene-Disease Associations	1.0	1.08762
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6960179__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-U8XE-0226-SM-4E3J3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11728
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.847989
Sinomenine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242344
Hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
HD-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
PMC6966427__F1	PFOCR Pathway Figure Associations 2023	1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.91213
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Clotrimazole_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300496
TOM1L1	Pathway Commons Protein-Protein Interactions	1.0	null
PWR-1E	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.13142
ULK-101_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0259275
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41831
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859366
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.809
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3743959__F1	PFOCR Pathway Figure Associations 2023	1.0	null
increases	GeneRIF Biological Term Annotations	1.0	null
PMC7879300__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PPARG-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.551298
CTV1DM	DepMap CRISPR Gene Dependency	1.0	8.3281
Bestatin_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00952081
Brain Diseases	CTD Gene-Disease Associations	1.0	1.0189
MAGED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5629
positive regulation of innate immune response	GO Biological Process Annotations 2015	1.0	null
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.04676
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955002
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7919-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
craniofacial osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J9-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUZC-0726-SM-4BOPH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00572
Sulfisoxazole_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264044
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.050142
H3K27me3_iPS-20b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of cytokine-mediated signaling pathway	GO Biological Process Annotations 2023	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14941
FE-82-WB22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392645
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923406
LRRC40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5137
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3301
PMC5852779__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	1.89441
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217346
GSE84678,GSE93902_3_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComUP-List-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Salicylic acid_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258583
GATA4-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985228
GSE131565_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180785
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988978
Learning Disorders	CTD Gene-Disease Associations	1.0	1.80077
Acute monocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4B-Supplemental_Table_S4B_Differentially_expressed_genes_upon_ZFX_Knock_down_in_MCF-7_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
interleukin-27 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.214
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of sequence-specific dna binding transcription factor activity	GO Biological Process Annotations 2015	1.0	null
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956889
PMC8591135__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06275
Coronary Artery Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-PWCY-0826-SM-48TCR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24772
NNT	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC128926__F2	PFOCR Pathway Figure Associations 2024	1.0	null
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.906275
PMC6461132__F1	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-FigS7d-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NECTIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71314
GSE159678_6_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of transcription, dna-templated	GO Biological Process Annotations 2015	1.0	null
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45432
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12801
Flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
PMC5579652__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4977549__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_nuc-DEGs_for_hnRNPK_KD_Nuclear_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TAL1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NG25_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0458773
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04222
GSE173873_4_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-663	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormal tumor necrosis factor level	MPO Gene-Phenotype Associations	1.0	null
PMC9465159__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CERS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10761
PMC2573957__F1	PFOCR Pathway Figure Associations 2024	1.0	null
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2776
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.58678
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinarybladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.50046
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02624
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82104
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0535
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.857947
HCC33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59141
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934972
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07697
PMC3131135__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0213
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52214
OV7	CCLE Cell Line Gene CNV Profiles	1.0	1.40678
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0926-SM-3NB2Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28111
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
il1r1	GeneRIF Biological Term Annotations	1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17406
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_17378_KD_Myc_SRP190223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.3653
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37633
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
LU-65	COSMIC Cell Line Gene Mutation Profiles	1.0	null
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-1026-SM-48TZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09056
GSE113221,GSE113968_6_v_1_prdm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33966
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE60367_2_v_1_cxcr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33135
NG25_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0300845
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245681
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891434
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37994
ps1	GeneRIF Biological Term Annotations	1.0	null
Sinomenine_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245966
GTEX-S4Q7-0926-SM-4AD5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60364
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.445275
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
Pyridoxine (hydrochloride)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106086
Perturb_422_KD_FOXM1_SRP371675	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC4345914__F2	PFOCR Pathway Figure Associations 2024	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13824
GSE166169_2_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	1.0	1.94877
DZIP3	Pathway Commons Protein-Protein Interactions	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209706
Perturb_13026_KO_RELA_SRP268648	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.02447
GSE210580_3_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NAA50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07667
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5-Fluorouracil_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0296711
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-320c	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
PMC6167544__F8	PFOCR Pathway Figure Associations 2024	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2696-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46H-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6844187-Table_15.xlsx-deg-S15_Table_Genes_that_exhibited_significant_differences_between_goats_and_sheep_FDR_10_Log2FC_2_in_response_to_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.27687
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.074022
positive regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101989
aspergillosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.40008
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.011
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alpelisib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0331523
abnormal circulating tumor necrosis factor level	MPO Gene-Phenotype Associations	1.0	null
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997209
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051402
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8423-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0336307
EA-02-ZO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217361
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08693
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
PMC11227377-2506586.f2.pdf-8-ARID5A_ARID5A	Rummagene Transcription Factor Associations 2026	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055515
GSE136627_3_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM32	Pathway Commons Protein-Protein Interactions	1.0	null
Balsalazide (sodium hydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.030498
PMC5167032__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PCSK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30876
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21256
HUPT4	CCLE Cell Line Gene CNV Profiles	1.0	1.64515
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25457
PMC6208316__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TRIM36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74561
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10327
MET_knockout_257_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.00091
PMC6307204__F5	PFOCR Pathway Figure Associations 2023	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2377356__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U9-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7994-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4418-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormal leukocyte count	GWASdb SNP-Phenotype Associations	1.0	0.390094
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TOLLIP	Pathway Commons Protein-Protein Interactions	1.0	null
nfkappab	GeneRIF Biological Term Annotations	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04387
KMH-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Heart Failure	CTD Gene-Disease Associations	1.0	1.22948
PMC5569249__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64294
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842572
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7432002__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver Failure	CTD Gene-Disease Associations	1.0	1.10838
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5565-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ctcfbinding	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3QU-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-CoV-1-host interactions	Reactome Pathways 2024	1.0	null
Torkinib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237486
abnormality of the ribs	GWASdb SNP-Phenotype Associations	1.0	0.60143
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CD36	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46335
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.138802
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.069
PMC6384427__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_5_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2907574__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE173810_4_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174701_5_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
PMC4629506__F1	PFOCR Pathway Figure Associations 2024	1.0	null
NR3C1	ChEA Transcription Factor Targets	1.0	null
GTEX-SUCS-0926-SM-4DM4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848237
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
PMC5039587__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3957
DT-061_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0269199
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041091
PMC8086363-12974_2021_2154_MOESM7_ESM.docx-0-ZNF558_ZNF558	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5244336__F9	PFOCR Pathway Figure Associations 2024	1.0	null
sclerotic forearm bones	GWASdb SNP-Phenotype Associations	1.0	0.60143
SF295	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.62823
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60759
GTEX-RWS6-0726-SM-47JXI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37602
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_4_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lipoic acid_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245092
immune	GAD High Level Gene-Disease Associations	1.0	0.293278
Rifaximin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0295045
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34013
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal axial skeleton morphology	GWASdb SNP-Phenotype Associations	1.0	0.359031
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066599
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mastitis	DisGeNET Gene-Disease Associations	1.0	null
HCC-15	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.24847
PMC9389448__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78946
S100A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44532
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.878744
IRAK3	KEA Substrates of Kinases	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3731-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fostamatinib (disodium hexahydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0236722
abnormality of the urethra	GWASdb SNP-Phenotype Associations	1.0	0.379728
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31316
PMC8228919__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.53203
CBX3	ENCODE Transcription Factor Targets	1.0	null
toll-like receptor 4 signaling pathway	GO Biological Process Annotations 2015	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.934982
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
response to interleukin-1	GO Biological Process Annotations 2023	1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33354
NALM-6	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.05147
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
MIS18BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08338
UBE2L6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68787
Spleen cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.285
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RB-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIST1H2AI	Pathway Commons Protein-Protein Interactions	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19099
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.02442
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4427
PMC7544743__F1	PFOCR Pathway Figure Associations 2023	1.0	null
immune system disease	GWASdb SNP-Disease Associations	1.0	0.141241
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.541117
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33218
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUZC-0526-SM-4BOPF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05956
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.975502
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.945
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220105
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14523
leukopenia	GWASdb SNP-Disease Associations	1.0	0.491681
bacterial-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
LE-60-VC29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211292
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_2_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amplifier	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38918
ULK-101_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0371167
Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Colitis	DisGeNET Gene-Disease Associations	1.0	null
FBXL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38562
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
patchy changes of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE151612_4_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01489
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Terfenadine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243941
VPS51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68803
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193282
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
postcentral gyrus, left, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.824287
Perturb_6604_KO_STK11_ERP124775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.17548
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887206
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43316
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.22975
regulation of signal transduction	GO Biological Process Annotations 2023	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.97287
PMC2731164__F7	PFOCR Pathway Figure Associations 2023	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
T-98G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
pattern recognition receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
TE1	CCLE Cell Line Gene CNV Profiles	1.0	1.35212
PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S4-Supplemental_Table_S4_Differentially_expressed_genes_between_cases_with_G-CSF-induced_pY-STAT3_DMFI_1_5_STAT3_Low_v_DMFI_1_5_STAT3_High_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H226	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.88376
GSE98755,GSE98756_1_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993684
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168329
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.80077
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.51004
PMC7674197__F1	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10818
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27959
Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4765310__F2a	PFOCR Pathway Figure Associations 2023	1.0	null
hematopoietic system phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
endosomal part	GO Cellular Component Annotations 2015	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102425
ESR1	JASPAR Predicted Transcription Factor Targets	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01614
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25324
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RKN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUIT-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38745
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5569249__F2	PFOCR Pathway Figure Associations 2023	1.0	null
TLR10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
J-774A.1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
appendices_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.00297
PMC7873566__F3	PFOCR Pathway Figure Associations 2023	1.0	null
synovial fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214576
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02834
Endolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.362
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2813
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16887
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.838015
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27375
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4904-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.53559
GSE82032_3_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
H4 neuroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
Fusidic acid_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0335925
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Toll Like Receptor TLR1:TLR2 Cascade	Reactome Pathways 2024	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
superior parietal lobule, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.930037
DT-061_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.031192
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ULK-101_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00942731
Perturb_3758_KD_TSG101_SRP325061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Diseases	CTD Gene-Disease Associations	1.0	1.05237
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLP-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
bone mineral density	GAD Gene-Disease Associations	1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226049
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
activation of innate immune response	GO Biological Process Annotations 2015	1.0	null
PMC4292165__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6553925__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243331
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53651
A549_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135449
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MEIOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33507
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08829
Perturb_1807_KO_lncFAO_SRP192861	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.52222
NR2F2	ENCODE Transcription Factor Targets	1.0	null
NEDD4L	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
opportunistic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.165435
HSF1_01_178	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.08339
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
BV-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.26
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cleavage	GeneRIF Biological Term Annotations	1.0	null
L-Thyroxine (sodium salt pentahydrate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209124
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FUOV1	CCLE Cell Line Gene CNV Profiles	1.0	1.42088
EGR1	ENCODE Transcription Factor Targets	1.0	null
GSE203408_0_v_3_curcumin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5945810__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ranolazine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0354235
FAM83F	Pathway Commons Protein-Protein Interactions	1.0	null
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.360162
Prostate adenocarcinoma_PRAD_TCGA-CH-5761-11A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
consists	GeneRIF Biological Term Annotations	1.0	null
Lopinavir_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.035029
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GE-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
HSF1-23293686-STHDH_STRIATAL-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847022
RAJI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
PMC5748601__F1	PFOCR Pathway Figure Associations 2023	1.0	null
CAL54	CCLE Cell Line Gene Expression Profiles	1.0	1.69588
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.76501
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46588
apoptosis	KEGG Pathways	1.0	null
CBLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02046
SBI-0640756_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.033407
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02246
TLR6	Pathway Commons Protein-Protein Interactions	1.0	null
innate immune response	GO Biological Process Annotations 2015	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4248_KD_IKZF2_SRP326885	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.24955
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985978
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
lymphoma	GWASdb SNP-Disease Associations	1.0	0.794591
Fibrosis	CTD Gene-Disease Associations	1.0	1.65555
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6877906__F1	PFOCR Pathway Figure Associations 2023	1.0	null
HEC108	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9634190__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891294
lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261964
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221677
CTDSPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09796
GSE173873_8_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48055
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
frontal operculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.9068
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.81172
XRK3F2_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266649
Tomivosertib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224306
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84848
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC5415836__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE208254_3_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60783
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2509
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929236
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Neurotrophin signaling pathway	KEGG Pathways 2026	1.0	null
ctcf	GeneRIF Biological Term Annotations	1.0	null
RCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40263
Ft	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mania	GWASdb SNP-Phenotype Associations	1.0	0.680832
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Puberty, Precocious	CTD Gene-Disease Associations	1.0	1.25713
abnormal external genitalia	GWASdb SNP-Phenotype Associations	1.0	0.234104
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
Lung epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.431
PMC11123779__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3902-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-2.08562
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272814
SAP30	ENCODE Transcription Factor Targets	1.0	null
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38334
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2358
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.277264
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32195
GSE205163,GSE205164_9_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3402799__F2	PFOCR Pathway Figure Associations 2023	1.0	null
A549_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025605
TIA1_KO_GSE54418_263_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
MPV17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18196
Lung adenocarcinoma_LUAD_TCGA-49-4488-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X261-1026-SM-3NMDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34269
IL-1 signaling pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE168797_4_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934649
PMC12502296-40246_2025_829_MOESM3_ESM.xlsx-Supplementary_Table_6-Supplementary_Table_6_Significant_eQTLs_MR_results_between_the_expression_of_druggable_genes_and_NSCLC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13702
Skin-endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	4.47971
PMC5664350__F4	PFOCR Pathway Figure Associations 2023	1.0	null
Salmonellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
Lung epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.396
mir373	GeneRIF Biological Term Annotations	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
KMOE-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5006-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC2962956__F1	PFOCR Pathway Figure Associations 2023	1.0	null
TNFSF9	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phosphorylation	GO Biological Process Annotations 2015	1.0	null
PMC6790574__F1	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of response to cytokine stimulus	GO Biological Process Annotations 2015	1.0	null
fallopian tube	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2962956__F1	PFOCR Pathway Figure Associations 2024	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03263
than	GeneRIF Biological Term Annotations	1.0	null
VZ in midcingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2737
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
PMC7367493__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398055
PMC7037830__F4	PFOCR Pathway Figure Associations 2023	1.0	null
PMC2624576__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
Larotrectinib sulfate_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0170897
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lupus Erythematosus	DisGeNET Gene-Disease Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6988-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.854151
GTEX-S32W-2226-SM-2XCAY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833208
PMC3085878__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Larotrectinib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173907
RAP2B	Pathway Commons Protein-Protein Interactions	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Promonocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.138
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168826
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
Respiratory Tract Infections	CTD Gene-Disease Associations	1.0	1.06771
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6581583__F3	PFOCR Pathway Figure Associations 2024	1.0	null
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.881269
GSE211128_2_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.145293
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.071871
choroidal sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
jeg-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297089
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859366
PMC4118962__F1	PFOCR Pathway Figure Associations 2023	1.0	null
cellular response to interleukin-1	GO Biological Process Annotations 2023	1.0	null
Contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
GTEX-XUJ4-0926-SM-4BOPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983003
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59711
Estrone sulfate (potassium)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0128431
PMC7578260__F2	PFOCR Pathway Figure Associations 2024	1.0	null
FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAP2K4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02516
pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.336336
interleukin-23 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.719
abnormality of male external genitalia	GWASdb SNP-Phenotype Associations	1.0	0.234104
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
MZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.86256
ABC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
j-774a.1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.436438
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8526712__F5	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
enhancing	GeneRIF Biological Term Annotations	1.0	null
abnormal cytokine level	MPO Gene-Phenotype Associations	1.0	null
GTEX-PLZ6-0626-SM-3P61B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46957
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7773-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
SYNM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42603
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MGAT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05316
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16332
irak2	GeneRIF Biological Term Annotations	1.0	null
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254133
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.125839
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC6055827__F4	PFOCR Pathway Figure Associations 2024	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.502675
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormal macrophage physiology	MGI Mouse Phenotype Associations 2023	1.0	null
PMC3672773__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
ovary_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27402
GSE173873_5_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUW1-1526-SM-4BOOY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85679
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19164
peritonitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.187415
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.675487
NB6	DepMap CRISPR Gene Dependency	1.0	3.62152
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880297
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14782
organelle part	GO Cellular Component Annotations 2015	1.0	null
Aortic endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33286
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.013
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20327
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.8429
PELI3	Pathway Commons Protein-Protein Interactions	1.0	null
LCLC103H	CCLE Cell Line Gene Expression Profiles	1.0	1.46056
HSF1	ChEA Transcription Factor Targets	1.0	null
GTEX-WZTO-0426-SM-3NM99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40714
ULK1_knockout_198_GSE60778	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.50659
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08862
positive regulation of kinase activity	GO Biological Process Annotations 2015	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LUC7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39472
regulation of cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cepharanthine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210846
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Capivasertib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264704
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_11_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.45389
regulation of cytokine-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.959092
cdkn1b_18180298_3t3_lof_mouse_gpl1261_gse9161	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.291152
PMC4922528__F2	PFOCR Pathway Figure Associations 2024	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Ribonuclease III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal adaptive immunity	MPO Gene-Phenotype Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169896
Protein kinase domain	InterPro Predicted Protein Domain Annotations	1.0	null
ISGF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.223
PMC4364059__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6438015-13148_2019_651_MOESM7_ESM.xlsx-Sheet1-Table_S2_Genes_exhibiting_both_significantly_increased_promoter_methylation_and_significantly_lowered_expression_in_CRISPR_TET2-KO_cells_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133661_0_v_1_c19orf12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.04978
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.38835
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSK2578215	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
PMC5748601__F1	PFOCR Pathway Figure Associations 2024	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.89957
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25953
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071042
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UG-01A-32R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A204	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.4813
Terminal loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
Everolimus_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0294155
attention deficit hyperactivity disorder	GWASdb SNP-Disease Associations	1.0	0.657565
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.466
RUNX1-22343733-PBMC-HUMAN-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKT1	Hub Proteins Protein-Protein Interactions	1.0	null
Terfenadine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0252301
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458335
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	1.7416
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
ES6	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.20412
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17782
positive regulation of protein serine/threonine kinase activity	GO Biological Process Annotations 2015	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97479
Brain Lower Grade Glioma_LGG_TCGA-DU-6395-01A-13R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thrombocytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
ETC-206_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214027
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829021
abnormality of the skull base	GWASdb SNP-Phenotype Associations	1.0	0.60143
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IL-1 Signaling Pathway(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Binimetinib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237314
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60543
Kidney renal clear cell carcinoma_KIRC_TCGA-GK-A6C7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.07721
MRPS25	Pathway Commons Protein-Protein Interactions	1.0	null
GFI1B	ChEA Transcription Factor Targets	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the glomerulus	GWASdb SNP-Phenotype Associations	1.0	0.409473
RLIM	Pathway Commons Protein-Protein Interactions	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73864
GSE227137,GSE227139_2_v_3_themis2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.95003
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42617
Fatigue	CTD Gene-Disease Associations	1.0	1.04684
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41504
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.198991
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865251
GSE203308_1_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
lung epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.495309
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1224-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal sensitivity to induced morbidity/mortality	MPO Gene-Phenotype Associations	1.0	null
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42221
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
PMC4261819__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Ribociclib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0258028
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11856
GSE158743_1_v_2_nfkbia_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9454636__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_752_KD_NPL_SRP360165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.422
Toll Like Receptor 10 (TLR10) Cascade	Reactome Pathways 2014	1.0	null
hsa-miR-4738-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.815
myd88-dependent toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC4765310__F2a	PFOCR Pathway Figure Associations 2024	1.0	null
Premature Birth	CTD Gene-Disease Associations	1.0	1.14885
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
LU65	CCLE Cell Line Gene Mutation Profiles	1.0	null
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Celiac Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176129
496100480_HIP_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3601
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19043
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal inflammatory response	MPO Gene-Phenotype Associations	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Eosinophil count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
irak1	GeneRIF Biological Term Annotations	1.0	null
immune response-regulating signaling pathway	GO Biological Process Annotations 2015	1.0	null
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
u-937 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262304
GSE160246_0_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083095
Lung adenocarcinoma_LUAD_TCGA-55-8091-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11282
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978396
ERG_01_216	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.64549
PMC9027975__F2	PFOCR Pathway Figure Associations 2024	1.0	null
SOX2_01_349	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59355
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT4-19710469-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.725
COX7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17477
Perturb_14563_KD_SULF2_SRP361678	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HCFC1	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16887
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03077
Tirabrutinib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222804
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.680832
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.85852
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16198
osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071631
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.578106
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
toll-like receptor 4 signaling pathway	GO Biological Process Annotations 2025	1.0	null
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9518217__F1	PFOCR Pathway Figure Associations 2024	1.0	null
RC-K8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMAD2	Pathway Commons Protein-Protein Interactions	1.0	null
LS-513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC4273448__F7	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.621
PMC6879454-Data_Sheet_1.xlsx-AA_disease-Unnamed_4_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21373
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
Epstein-Barr virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31673
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28916
PMC7763461__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MLH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28253
Albuminuria	CTD Gene-Disease Associations	1.0	1.05015
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADGRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64942
Toll Like Receptor TLR6:TLR2 Cascade	Reactome Pathways 2024	1.0	null
T-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3118	DepMap CRISPR Gene Dependency	1.0	3.28284
GSE166783_6_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
NB14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.50637
Radotinib_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0111294
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.841044
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Measles	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30228
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135514_8_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50461
19838208-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Toll Like Receptor 9 (TLR9) Cascade	Reactome Pathways 2024	1.0	null
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
Intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.353
VDR-23401126-LCL-AND-THP1-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Amoebocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
KHNYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41639
PMC9582522__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.233539
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_LEUTX	Rummagene Transcription Factor Associations 2026	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20113
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7035
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.458373
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
interleukin-6 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.916
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3402799__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Dabrafenib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240256
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.981975
GSE223008_9_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55C-0726-SM-48FCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928462
Eczema	HuGE Navigator Gene-Phenotype Associations	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.802293
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.326432
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
JHH4	CCLE Cell Line Gene Mutation Profiles	1.0	null
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Darinaparsin_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176576
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
BCAP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36999
VTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57363
GSE114992,GSE114993_0_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
supramarginal gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.951515
A549_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129557
interleukin	GeneRIF Biological Term Annotations	1.0	null
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64247
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMPCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10413
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.677017
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939589
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06615
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
Tucidinostat_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00912447
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52281
Thymol_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0419219
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal blood homeostasis	MPO Gene-Phenotype Associations	1.0	null
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48395
PMC12634441-41375_2025_2771_MOESM7_ESM.xlsx-RNAseq-Table_S2_Bulk_RNA-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
Endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Nose disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6476
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09932
KLF4	ChEA Transcription Factor Targets	1.0	null
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
COLO-684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-0.905861
sclerosis of metaphyses of the upper limbs	GWASdb SNP-Phenotype Associations	1.0	0.60143
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Hashimoto Disease	DisGeNET Gene-Disease Associations	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.76354
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F5-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65098
Temsirolimus_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202173
GSE254155_1_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03803
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002594
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-338-NR4A3_NR4A3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9500_KI_Trp53_SRP201382	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.6618
OTS514_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0241556
TLR7	Pathway Commons Protein-Protein Interactions	1.0	null
A549_2-Methoxyestradiol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225651
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17226
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Verteporfin_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00824849
PMC3144045__F1	PFOCR Pathway Figure Associations 2023	1.0	null
4EGI-1_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212449
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.11466
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109228
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_baboon_DRSG_lowerRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Olanzapine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208914
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.854528
valproic acid_mus musculus_gpl6885_gse35291	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
CJM	CCLE Cell Line Gene Mutation Profiles	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2092
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LC1SQ	DepMap CRISPR Gene Dependency	1.0	2.1753
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55068
Lung adenocarcinoma_LUAD_TCGA-44-6779-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Reactome Pathways 2014	1.0	null
toll-like receptor tlr6:tlr2 signaling pathway	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7794-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5629438__F3	PFOCR Pathway Figure Associations 2023	1.0	null
FZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57154
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fibrin complement receptor 3 signaling	WikiPathways Pathways 2024	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TP53BP1_KD_GSE54268_670_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
HEPG2	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.92141
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
Dehydration_Hypothalamus_GSE3125	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.41039
Hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.028
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239541_8_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84323
PMC4824131__F1	PFOCR Pathway Figure Associations 2023	1.0	null
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08763
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925775
Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A3EE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neutropenia	GWASdb SNP-Phenotype Associations	1.0	0.710458
Systemic scleroderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839704
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30687
toll-like receptor 3 signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Fever	CTD Gene-Disease Associations	1.0	1.26236
Brain Lower Grade Glioma_LGG_TCGA-QH-A6XA-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TLR8	Pathway Commons Protein-Protein Interactions	1.0	null
lung	GeneRIF Biological Term Annotations	1.0	null
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.74541
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BHT101	CCLE Cell Line Gene Expression Profiles	1.0	2.09348
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
regulation of response to cytokine stimulus	GO Biological Process Annotations 2023	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	1.13226
saos-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214954
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24297
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.77943
helper t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174684
EGR1	ChEA Transcription Factor Targets	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	1.0	2.71658
CSE1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54766
ERCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05059
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC2624576__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC11615365-41467_2024_54246_MOESM4_ESM.xlsx-RT4-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5813
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZD-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
first	GeneRIF Biological Term Annotations	1.0	null
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.953373
increased total body fat amount	IMPC Knockout Mouse Phenotypes	1.0	null
Amnion epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
PMC4394028__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3W-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Phagocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.526
Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151119_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Biliary epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
HMGN3	ENCODE Transcription Factor Targets	1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
hESC_Derived_CD184+_Endoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.0754
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC5664350__F3	PFOCR Pathway Figure Associations 2023	1.0	null
activated TAK1 mediates p38 MAPK activation	Reactome Pathways 2014	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057359
Kidney Failure, Chronic	CTD Gene-Disease Associations	1.0	1.03976
DMS454	CCLE Cell Line Gene Mutation Profiles	1.0	null
UBR2	Pathway Commons Protein-Protein Interactions	1.0	null
essential	GeneRIF Biological Term Annotations	1.0	null
PMC84262__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC4261819__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Cytarabine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0290729
abnormality of the rib cage	GWASdb SNP-Phenotype Associations	1.0	0.60143
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16336
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.856
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30818
cervicitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.776977
dds	GeneRIF Biological Term Annotations	1.0	null
PMC8585639__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EI-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3536146__F8	PFOCR Pathway Figure Associations 2023	1.0	null
kinase2	GeneRIF Biological Term Annotations	1.0	null
PMC10984988__F9	PFOCR Pathway Figure Associations 2024	1.0	null
Tofacitinib (citrate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0358222
GTEX-VUSG-2426-SM-4KKZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56049
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDK1_knockout_265_GSE42187	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.87436
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
Trametinib (DMSO_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0422718
Thrombosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
acute myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081665
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36411
urinary bladder	HPA Tissue Gene Expression Profiles	1.0	1.17161
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE119345_2_v_4_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vismodegib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0229098
Azithromycin (hydrate)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024422
REST	ChEA Transcription Factor Targets	1.0	null
regulation of kinase activity	GO Biological Process Annotations 2015	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metolazone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.859209
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of upper limb metaphysis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.259
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15609
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
costochondral joint sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colonic epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
MME	Pathway Commons Protein-Protein Interactions	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.163244
respiratory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.140127
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.9652
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4107957__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC7662392__F2	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-1326-SM-3NB1B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11302
Blood Basophil Count (Lab Test)	DisGeNET Gene-Phenotype Associations	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BI-78D3_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268821
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.896848
Perturb_7872_KD_MYO6_SRP258737	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC8851354-Table_5.xlsx-FUS-DDIT3_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_FUS-DDIT3_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40267
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal immune serum protein physiology	MPO Gene-Phenotype Associations	1.0	null
MRPL44	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.974212
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5039587__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Synovial fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.297
positive regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
nephrosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36712
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01019
regulation of defense response	GO Biological Process Annotations 2015	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052638
PMC8629847__F1	PFOCR Pathway Figure Associations 2024	1.0	null
OVCAR-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
PMC3216306__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC1751079__F1	PFOCR Pathway Figure Associations 2023	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04973
GSE190555,GSE190557_2_v_3_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GATA5_KO_GDS4809_170_mouse_Lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Terfenadine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271561
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-0726-SM-447AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00603
phosphorylation	GO Biological Process Annotations 2025	1.0	null
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50764
nucleus	GO Cellular Component Annotations 2023	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9134593__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Erythromycin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176163
fungal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063261
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3297025__F1	PFOCR Pathway Figure Associations 2024	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65707
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2807
C8166	DepMap CRISPR Gene Dependency	1.0	16.1223
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05748
Marginal zone lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
hsa-miR-4665-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RERFLCAI	CCLE Cell Line Gene CNV Profiles	1.0	2.36098
PMC7697665__F4	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6055827__F4	PFOCR Pathway Figure Associations 2023	1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.84498
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fostamatinib (disodium hexahydrate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146753
ZNF202	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10666
highlights	GeneRIF Biological Term Annotations	1.0	null
SW156	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.46329
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ML264_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0350963
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Omeprazole (sodium)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0341918
T47D	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.88916
abnormal immune system physiology	MPO Gene-Phenotype Associations	1.0	null
JRA - Juvenile rheumatoid arthritis_Peripheral blood mononuclear cell_GSE7753	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.83578
Rapamycin_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0172728
positive regulation of protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
short attention span	GWASdb SNP-Phenotype Associations	1.0	0.560832
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-1426-SM-46MVW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02301
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.416
Perturb_7804_KO_Ythdc1_SRP065329	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
RXR-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC5945810__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE151119_2_v_1_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tendon sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.296
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882407
JM1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.15616
Psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.694
protein kinase activity	GO Molecular Function Annotations 2015	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-302d	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106836
MyD88-dependent toll-like receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
PMC7468443-Data_Sheet_5.xlsx-PolyIC_6h_over_LPS_6h-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
cellular response to stress	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11806
crystal	GeneRIF Biological Term Annotations	1.0	null
decreased interferon-alpha secretion	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Econazole_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0108413
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0686
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47743
LXR-623	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
A549_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142231
HUPT4	CCLE Cell Line Gene Expression Profiles	1.0	1.86274
RAB43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65744
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.21647
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
Clofarabine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0254466
Pulmonary Fibrosis	CTD Gene-Disease Associations	1.0	1.31927
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020735
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6877906__F1	PFOCR Pathway Figure Associations 2024	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
Death domain	InterPro Predicted Protein Domain Annotations	1.0	null
Perturb_13025_KO_REL_SRP268648	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.15409
venetoclax_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024481
traf6	GeneRIF Biological Term Annotations	1.0	null
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CNNM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25527
regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VMRC-MELG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.72344
promonocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262304
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6167544__F8	PFOCR Pathway Figure Associations 2023	1.0	null
PMC11747033-Table1.xlsx-Sup_Table_S1-IFNy_LPS_TREATED_HMEC_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INTS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66669
response to cytokine	GO Biological Process Annotations 2015	1.0	null
Sulfisoxazole_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.019278
ITCH	Pathway Commons Protein-Protein Interactions	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EX229_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.040301
GSE149359_3_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.965075
ZNF774	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.022
Severe acute respiratory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11046693-pnas.2320938121.sapp.pdf-23-HOXC10_HOXC10	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
major	GeneRIF Biological Term Annotations	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.994383
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22466
bone marrow-derived dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221989
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20303
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0263154
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mv.1.lu	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.416
PMC3438932__F7	PFOCR Pathway Figure Associations 2023	1.0	null
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.656464
Acute Myeloid Leukemia_LAML_TCGA-AB-3001-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7303083__F7	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
NGP	DepMap CRISPR Gene Dependency	1.0	2.85922
PMC7993742__F3	PFOCR Pathway Figure Associations 2023	1.0	null
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.412031
SNU1033	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26558
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07517
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24581
GSE196699_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245362
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21276
viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062071
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219707
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08013
Lung squamous cell carcinoma_LUSC_TCGA-56-7731-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4EGI-1_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219796
negative	GeneRIF Biological Term Annotations	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26533
PMC6773509__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Daidzin_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0239264
PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.019
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Belumosudil_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0218226
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8914285__F3	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8359015-Table_1.xlsx-Sheet1-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0362
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCAS	CCLE Cell Line Gene Expression Profiles	1.0	1.47942
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
tretinoin_mus musculus_gpl1261_gds4294	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IRAK1-IRAK2 complex	CORUM Protein Complexes	1.0	null
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965898
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11955568-41467_2025_57429_MOESM9_ESM.xlsx-Data_S7-JUN_OIS_Martinez2020_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173873_8_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4199593__F6	PFOCR Pathway Figure Associations 2023	1.0	null
SARM1	Pathway Commons Protein-Protein Interactions	1.0	null
CA-66-YB17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207007
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929351
Lapatinib ditosylate_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134955
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
FOXM1	ENCODE Transcription Factor Targets	1.0	null
Lumateperone (tosylate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0299375
NOLC1	Pathway Commons Protein-Protein Interactions	1.0	null
TTLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06517
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
immunity	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-1283	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Toll Like Receptor 7/8 (TLR7/8) Cascade	Reactome Pathways 2024	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
tonsil_8e1	HPA Tissue Sample Gene Expression Profiles	1.0	1.66332
Secretory IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.2521
PMC9106063__F7	PFOCR Pathway Figure Associations 2024	1.0	null
PDS5A	Pathway Commons Protein-Protein Interactions	1.0	null
Idarubicin (hydrochloride)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0159577
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160107
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of immune response	GO Biological Process Annotations 2015	1.0	null
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02849
decreased susceptibility to endotoxin shock	MPO Gene-Phenotype Associations	1.0	null
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220378
attention deficit hyperactivity disorder	GWASdb SNP-Phenotype Associations	1.0	0.560832
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2414
Perturb_4012_KD_AHR_SRP262152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC7764362__F2	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56433
PMC7746484__F1	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BT549	CCLE Cell Line Gene CNV Profiles	1.0	1.44764
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0426-SM-3K2BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23174
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AMZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12241
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39191
FB-86-IO73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226959
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.03874
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46671
asthma	GWASdb SNP-Disease Associations	1.0	0.794591
CTAGE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34157
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.90666
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
Allergic contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
abnormal acute inflammation	MPO Gene-Phenotype Associations	1.0	null
structure	GeneRIF Biological Term Annotations	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5245798-pgen.1006538.s023.xlsx-Sheet1-HOXA2_HOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H358	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.07386
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.5015
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hemangioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.503824
otosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
IGR39	CCLE Cell Line Gene CNV Profiles	1.0	1.33403
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.149282
NOD1/2 Signaling Pathway	Reactome Pathways 2024	1.0	null
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09441
GSE223008_0_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.083
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSK189254A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O7-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119533
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.908
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37982
Vitamin K4_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0057222
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60822
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200897_1_v_0_pold1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
protein phosphorylation	GO Biological Process Annotations 2025	1.0	null
Peritonitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
Bentamapimod_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0396369
interleukin-1 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.86
GSE205163,GSE205164_1_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
mortality/aging	MPO Gene-Phenotype Associations	1.0	null
Capmatinib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00938793
PMC9194156__F2	PFOCR Pathway Figure Associations 2024	1.0	null
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-2964a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MJ	DepMap CRISPR Gene Dependency	1.0	15.8098
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.22343
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
BE-28-WW67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200542
TAF7L	ChEA Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T-cell non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24534
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.093238
Perturb_4387_KO_STAG2_SRP348449	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.543
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266821
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Reactome Pathways 2024	1.0	null
Olfactory placode cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
PMC11699082-BLOODA_ADV-2023-012291-mmc1.xlsx-Sheet1-CD37_inv_corr_top100_GSE10846_CHOP_ABC_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
STT3A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3923659__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_15564_KD_ATF6_SRP364933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.3579
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.8775
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Toll signaling pathway	GO Biological Process Annotations 2025	1.0	null
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132604
abnormality of the eye	GWASdb SNP-Phenotype Associations	1.0	0.086457
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60868
16293578-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20536
PCI-38	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91269
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4459	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
DIABLO	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.86509
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10296711__F12	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15301_KO_Tet1/Tet2/Tet3_SRP318893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.0458
Perturb_12579_KD_SMO_SRP254554	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ZFX	ChEA Transcription Factor Targets	1.0	null
SARS-CoV NSP16_Day2_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.7587
PMC3216306__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05772
Perturb_15297_OE_circCUL2_SRP315212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.80239
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Captopril_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0336281
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972865
PMC6773509__F2	PFOCR Pathway Figure Associations 2023	1.0	null
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23504
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.377531
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28128
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Idarubicin (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188046
Perturb_14358_KD_XPR1_SRP347870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.34639
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.838634
SP4	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hypersensitivity reaction type ii disease	GWASdb SNP-Disease Associations	1.0	0.141053
Lung adenocarcinoma_LUAD_TCGA-55-8511-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1618	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96721
GTEX-WFJO-0726-SM-4LVM8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01186
PMC6161786__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Epstein-Barr Virus Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-CoV-2-host interactions	Reactome Pathways 2024	1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
VTP-27999	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40349
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09061
Endothelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03642
Hemorrhage	CTD Gene-Disease Associations	1.0	1.61897
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of nf-kappab transcription factor activity	GO Biological Process Annotations 2015	1.0	null
GSK1059615_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184742
CCRF-CEM	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.45421
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1887
Adult respiratory distress syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
FAAH	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH209	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3367
PMC7205036__F11	PFOCR Pathway Figure Associations 2024	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.20907
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
therapeutic	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18339
PMC4151153__F2	PFOCR Pathway Figure Associations 2023	1.0	null
OAW42	DepMap CRISPR Gene Dependency	1.0	3.13278
PMC8971392-41398_2022_1905_MOESM4_ESM.xlsx-LPS_stimulation-Table_S3_Top_differentially_expressed_genes_FDR-corrected_P-value_0_01_absolute_log2FC_2_identified_in_monocytes_after_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Arbutin_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227391
METTL7A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04103
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSF1-23293686-STHDH-STRIATAL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Exanthema	CTD Gene-Disease Associations	1.0	1.05793
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210580_3_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9-ING-41_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224147
Artesunate_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0463981
PMC5593677__F2	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2,2'-Biquinoline	DeepCoverMOA Drug Mechanisms of Action	1.0	0.69
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65378
SOWAHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05675
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18807
Zileuton_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0158291
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.021429
20215513-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-0926-SM-4DXU4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39878
Flumatinib (mesylate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232463
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
hsa-miR-1915	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE112860_9_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal interleukin level	MPO Gene-Phenotype Associations	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-487-CENPA_CENPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased interferon-alpha secretion	MGI Mouse Phenotype Associations 2023	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
spleen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.231206
positive regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_12_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Temuterkib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256297
HOXA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35179
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12322
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	0.271652
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.51411
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42891
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-PCM-NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4908-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079897
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423978
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2903975__F1	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58001
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37774
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08809
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227708
GATA3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21176
FPGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30291
Polkadots	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.723
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
applicable	GeneRIF Biological Term Annotations	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5582_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.61407
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2907574__F4	PFOCR Pathway Figure Associations 2024	1.0	null
PMC7746484__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CF-81-DS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204742
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Belzutifan_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182518
SARS-CoV-1 activates/modulates innate immune responses	Reactome Pathways 2024	1.0	null
CMAH_KO_GDS4200_114_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE210373_0_v_1_cntnap4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111102,GSE111105_3_v_5_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6124
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4208300__F3	PFOCR Pathway Figure Associations 2023	1.0	null
A549_JQ1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127615
GTEX-XQ3S-0926-SM-4BOPI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0125
hsa-miR-4436a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9168
PPP3CB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6182269__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
DRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24981
Progesterone	CTD Gene-Chemical Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EK-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.6926
SIRT4_KO_GDS4823_22_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Canagliflozin (hemihydrate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0325547
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.15425
PMC5571607__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A7U6-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21706
anomaly of the limb diaphyses	GWASdb SNP-Phenotype Associations	1.0	0.60143
NR3C1-23031785-PC12-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF578	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32385
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.02874
Ropivacaine (hydrochloride monohydrate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029728
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46128
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE222103_0_v_1_ybx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased tumor necrosis factor secretion	MPO Gene-Phenotype Associations	1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934758
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-1.03767
UTRN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148692,GSE148695_1_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU16	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73562
22RV1	CCLE Cell Line Gene Mutation Profiles	1.0	null
Homoharringtonine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0147668
serine/threonine protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.085433
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052307
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.48173
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Monocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.113
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33575
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-20-VA70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289791
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.657243
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPK5-1126-SM-3GAEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16099
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Scleroderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Bpe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2683
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36808
RUNX3	ENCODE Transcription Factor Targets	1.0	null
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
positive regulation of defense response	GO Biological Process Annotations 2015	1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.10625
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3606787__F8	PFOCR Pathway Figure Associations 2024	1.0	null
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
GTEX-U8XE-1426-SM-3DB8Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.6609
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-1470	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ULK-101_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01743
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74731
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.053
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.29657
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Amsacrine_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176551
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
polycythemia vera	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.379997
Perturb_17557_KO_STING1_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.73409
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.093
pleura	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.195639
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11233
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0418
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KH-CB19	DeepCoverMOA Drug Mechanisms of Action	1.0	0.91
receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.327956
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Activated TLR4 signalling	Reactome Pathways 2014	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HR-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.91569
MTA3	ENCODE Transcription Factor Targets	1.0	null
cytokine-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53446
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894263
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.93138
PMC4867367__F4	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6491485-41467_2019_9913_MOESM4_ESM.xlsx-DEGs_Figure_2C_D-Comparison_SS-BAL_CD14_CD16_MP_vs_LPS-BAL_CD14_CD16_MP_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98737
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855824
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.950099
GSE98964_0_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SF3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64203
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
choriocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169021
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FASTKD5	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1770	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.83674
disease	GWASdb SNP-Disease Associations	1.0	0.059101
GATA5_KO_GSE47425_50_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
abnormality of the upper arm	GWASdb SNP-Phenotype Associations	1.0	0.409473
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the hand	GWASdb SNP-Phenotype Associations	1.0	0.60143
TCF7	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8505-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07636
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35728
hsa-miR-519a	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC6330352__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GATA5_KO_GSE47425_386_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S32W-0326-SM-2XCBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68902
lipopolysaccharide-mediated signaling pathway	GO Biological Process Annotations 2015	1.0	null
surprisingly	GeneRIF Biological Term Annotations	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255442
Plasma membrane signaling receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.382
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.18293
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.59474
PMC3821792__F2	PFOCR Pathway Figure Associations 2024	1.0	null
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7412
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.96578
GSE158815_5_v_0_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_568_KD_MYO1C_SRP158445	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.699
Central nervous system lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04168
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3697_KD_FTO_SRP226373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.11655
NCOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64707
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.041
ZC3H12C	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212148
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
short tibia	MGI Mouse Phenotype Associations 2023	1.0	null
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5225
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829066
Acute Myeloid Leukemia_LAML_TCGA-AB-2814-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6588
th2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257907
Gemcitabine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0316923
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG8-0726-SM-3GILP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970572
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Esophageal Neoplasms	CTD Gene-Disease Associations	1.0	1.31506
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.947365
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
DY 131	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
patchy sclerosis of radial diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17795
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58877
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ESET-19884257-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43503
ion binding	GO Molecular Function Annotations 2015	1.0	null
interleukin-1-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
Aprepitant_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0220194
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944629
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52805
Alectinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.75
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4951
PMC5245798-pgen.1006538.s023.xlsx-Sheet1-ENSG00000105996_HOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
choriocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.149889
Perturb_6740_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.1161
Interleukin 1 IL 1 structural pathway	WikiPathways Pathways 2024	1.0	null
PMC9302576__F1	PFOCR Pathway Figure Associations 2024	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01839
GSE192771_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5664350__F3	PFOCR Pathway Figure Associations 2024	1.0	null
NFE2L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31564
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.83701
rectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262986
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary hematopoietic stem cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.850313
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_6910_KD_KLF5_SRP091857	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35296
abnormality of the ulna	GWASdb SNP-Phenotype Associations	1.0	0.60143
hsa-miR-875-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Toll Like Receptor TLR6:TLR2 Cascade	Reactome Pathways 2014	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
endosome membrane	GO Cellular Component Annotations 2015	1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.892708
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929236
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ASPC1	CCLE Cell Line Gene Expression Profiles	1.0	1.94901
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31321
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
19795415-Table1	GeneSigDB Published Gene Signatures	1.0	null
PMC5664350__F4	PFOCR Pathway Figure Associations 2024	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04189
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874788
vertebral body sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
death	GeneRIF Biological Term Annotations	1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13571
RNAi effector complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.421
PMC5863305__F1	PFOCR Pathway Figure Associations 2024	1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062195
BICR31	CCLE Cell Line Gene Expression Profiles	1.0	1.8112
Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS888T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57003
PMC4305100__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GSE215086_3_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
BCAT_BILD_ET_AL	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	2.01227
PMC7646980__F10	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8527892__F2	PFOCR Pathway Figure Associations 2024	1.0	null
PMC10454149__F1	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gingival fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.972
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.48033
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.15847
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00892
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34335
supramarginal gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02814
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
dexamethasone_homo sapiens_gpl570_gse37474	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of limbs	GWASdb SNP-Phenotype Associations	1.0	0.388966
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15024
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00595
PMC5039587__F2	PFOCR Pathway Figure Associations 2023	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42934
BIRC2	Pathway Commons Protein-Protein Interactions	1.0	null
Sapanisertib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0336288
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4629506__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC4985245__F1	PFOCR Pathway Figure Associations 2024	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
Toll-like receptor 1-Toll-like receptor 2 protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.263
PMC7037830__F4	PFOCR Pathway Figure Associations 2024	1.0	null
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291358
Cytoplasmic ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.588
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977662
regulation of innate immune response	GO Biological Process Annotations 2015	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39831
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2525
Ipatasertib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188468
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1239
decreased interleukin-6 secretion	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.892407
lung epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.187596
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.195346
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21625
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
transferase activity, transferring phosphorus-containing groups	GO Molecular Function Annotations 2015	1.0	null
Estrone sulfate (potassium)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237704
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signal transduction	GO Biological Process Annotations 2015	1.0	null
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4524	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
humeral sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC3421232__F5	PFOCR Pathway Figure Associations 2024	1.0	null
alpha	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal chemokine level	MGI Mouse Phenotype Associations 2023	1.0	null
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172086
PMC6695670__F2	PFOCR Pathway Figure Associations 2024	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.11577
MyD88-independent cascade	Reactome Pathways 2014	1.0	null
TAF7L-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Larotrectinib_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197283
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80513
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48507
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228764
Perturb_3339_KO_Cns4_SRP310440	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.9385
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191587
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.84994
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Amsacrine_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015906
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5952219__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Irinotecan_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0198049
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066355
BI-78D3_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0257875
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887851
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.89311
MAP2K7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P78B-0226-SM-3NB1Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927481
U-138MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.65021
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RH41	CCLE Cell Line Gene CNV Profiles	1.0	1.34803
PMC6753331__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Bloch-Sulzberger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Encorafenib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00641171
NLRP1 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.658
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Thymol_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0317188
PMC10296711__F10	PFOCR Pathway Figure Associations 2024	1.0	null
PK59	CCLE Cell Line Gene CNV Profiles	1.0	1.5683
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4A-Supplemental_Table_S4A_Differentially_expressed_genes_upon_ZFX_Knock_down_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	1.47007
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MO-0626-SM-4DM6P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06895
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.666809
PMC8108288-gutjnl-2020-321731supp004.xlsx-LPS_stimulation-gene_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MM-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARG-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_DN_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Carbamazepine_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.034499
PMC7334247-12031_2020_1490_MOESM2_ESM.xls-THAP1_S21T_vs_wt-Gene_Symbol_THAP1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Monocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
receptorassociated	GeneRIF Biological Term Annotations	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUJ4-1326-SM-4BOQ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53253
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A686-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Everolimus_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266562
Gallic acid_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024453
abnormality of the fundus	GWASdb SNP-Phenotype Associations	1.0	0.196352
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104301
Bacterial pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
RABGGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77467
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.00386
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45927
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83337
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	1.11651
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COQ10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05583
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22846
PMC7749645__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
NMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49015
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_TMP195_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168132
Cepharanthine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233311
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839336
PANC0213	CCLE Cell Line Gene Expression Profiles	1.0	2.24236
regulator	GeneRIF Biological Term Annotations	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3942-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
bronchus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080548
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.175416
PMC4453536__F8	PFOCR Pathway Figure Associations 2024	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.552093
TIRAP	Pathway Commons Protein-Protein Interactions	1.0	null
CFAP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57331
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
Perturb_10154_KD_ZRSR2_SRP265290	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.24709
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HO-1-N-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23963
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
PMC8905560__F4	PFOCR Pathway Figure Associations 2024	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282253
PMC3514012__F5	PFOCR Pathway Figure Associations 2024	1.0	null
myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.281776
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42831
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.70916
Coelomic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
thp-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.728563
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5521_KD_Apoa4_SRP393880	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.1149
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.112146
GSE173873_2_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.11574
PMC1751079__F1	PFOCR Pathway Figure Associations 2024	1.0	null
ATP5J2	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5250-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7156293__F3	PFOCR Pathway Figure Associations 2024	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68846
hsa-miR-4691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
abnormality of granulocytes	GWASdb SNP-Phenotype Associations	1.0	0.308216
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-BCL9-STAT3_targets_DEG_Control-GeneName_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE157555,GSE157556_5_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
TRIF (TICAM1)-mediated TLR4 signaling	Reactome Pathways 2024	1.0	null
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the humerus	GWASdb SNP-Phenotype Associations	1.0	0.60143
interleukin-1-mediated signaling pathway	GO Biological Process Annotations 2023	1.0	null
Pentamidine (isethionate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0129691
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869234
Lumateperone (tosylate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232573
systemic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.082871
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88467
precuneus, left, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.90769
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C1-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of transferase activity	GO Biological Process Annotations 2015	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GGPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27174
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.78479
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Acetohexamide_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02605
monocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.530298
hsa-miR-922	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
hsa-miR-146a-5p	MiRTarBase microRNA Targets	1.0	null
PMC2852602__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anastrozole_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0357833
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240716
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5710-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3137974__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.18193
smallpox	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.683493
GTEX-QESD-1526-SM-2S1QT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0831
placenta	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
19838208-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Acetohexamide_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232652
PMC2175514__F5	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6360815-supp_gr.239053.118_Supplemental_Table_S2.xlsx-MAFs_targets-Table_of_potential_MAF_targets_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cingulate gyrus, retrosplenial part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834235
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064303
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Norepinephrine (hydrochloride)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0575384
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48428
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.20654
Colitis	CTD Gene-Disease Associations	1.0	1.09401
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67F-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5104-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Amsacrine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136505
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Esophagitis	HuGE Navigator Gene-Phenotype Associations	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.94199
positive regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
Langerhans cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.563147
protein homodimerization activity	GO Molecular Function Annotations 2025	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
promoting	GeneRIF Biological Term Annotations	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.262
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983011
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7827341__F2	PFOCR Pathway Figure Associations 2023	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE141328_1_v_0_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.02262
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210580_5_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.278141
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hiv	GAD Gene-Disease Associations	1.0	null
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20529
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atopic dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
SNB75	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.3644
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48869
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.8128
CLEC4M	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-519b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJMC-1226-SM-4IHLI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975374
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548x	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PMC9505944__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK13	Kinase Library Serine Threonine Kinome Atlas	1.0	null
SARS-CoV MA15_Day1-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8854
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.3827
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.86
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964982
abnormal renal morphology	GWASdb SNP-Phenotype Associations	1.0	0.399972
PMC4887650__F1	PFOCR Pathway Figure Associations 2023	1.0	null
CP21R7_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255983
COLO201	CCLE Cell Line Gene CNV Profiles	-1.0	-2.64062
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167388
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105437
Paclitaxel_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244251
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0358795
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
differential	GeneRIF Biological Term Annotations	1.0	null
PMC7749645__F1	PFOCR Pathway Figure Associations 2024	1.0	null
toll-like receptor tlr1:tlr2 signaling pathway	GO Biological Process Annotations 2015	1.0	null
cellular response to lipopolysaccharide	GO Biological Process Annotations 2025	1.0	null
SP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1691
E2F3_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
kinase	GeneRIF Biological Term Annotations	1.0	null
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
toll-like receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP21R7_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226149
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
temporal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.089
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90751
H2BC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17102
TAL1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20925
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JVE015	DepMap CRISPR Gene Dependency	1.0	2.06428
RBM15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37098
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830054
Sum eosinophil basophil counts	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.822185
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04374
Sarcoma_SARC_TCGA-LI-A9QH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7170-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S3XE-1226-SM-4AD4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46707
AIP1-IRE1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
modification	GeneRIF Biological Term Annotations	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.907
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TIA1_KO_GSE54418_266_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE143790_0_v_1_bcl9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.65357
SOX2_Deficiency_GDS4853_320_human_AZ-521 gastric cancer (GC) cell line - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XMK1-2226-SM-4B673	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46404
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14528
Cholestasis	CTD Gene-Disease Associations	1.0	1.30117
hypersensitivity reaction disease	GWASdb SNP-Disease Associations	1.0	0.12469
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.7003
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02865
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1290	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877453
Neoplasm Invasiveness	CTD Gene-Disease Associations	1.0	1.1607
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42032
AZD1390_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213358
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trif-dependent toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Asthma	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83394
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2837270__F8	PFOCR Pathway Figure Associations 2023	1.0	null
PMC3929246__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01234
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OSBPL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71884
Myocardial Infarction	CTD Gene-Disease Associations	1.0	1.31237
INSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35161
Gallic acid_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282692
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52429
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POMQ-0526-SM-3GADD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06073
CORL88	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81647
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45788
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciclopirox_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233836
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A3OT-06A-23R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
monocyte-derived dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.268
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14269
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10356
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13173
PMC6960179__F5	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE110178_4_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20737
protein modification process	GO Biological Process Annotations 2015	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06305
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65539
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRVI1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5573_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GSE148692,GSE148695_7_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lidocaine (hydrochloride)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0317072
interleukin-35 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.209
Respiratory epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70I-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.905045
Cystic Fibrosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
PMC7662392__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36641
PMC6382076__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45564
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
PMC3606787__F8	PFOCR Pathway Figure Associations 2023	1.0	null
PMC5490603__F2	PFOCR Pathway Figure Associations 2023	1.0	null
KP-N-RT-BM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
decreased interleukin-6 secretion	MPO Gene-Phenotype Associations	1.0	null
Acitretin	DeepCoverMOA Drug Mechanisms of Action	1.0	1.7
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
partners	GeneRIF Biological Term Annotations	1.0	null
JHH-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827509
PMC6182269__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-T6MN-0826-SM-32PM4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19855
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tnf	GeneRIF Biological Term Annotations	1.0	null
endothelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012606
GSE146747_0_v_1_nr4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.944549
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
A549_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114683
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPTOR	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_13328_KD_Mnt_SRP149831	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.95216
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.051854
Perturb_12557_KO_Aire_SRP033579	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.93449
VANGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22974
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TICAM2	Pathway Commons Protein-Protein Interactions	1.0	null
CLGN	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hydroxyfasudil_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0335434
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215928
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of NF-kappaB transcription factor activity	GO Biological Process Annotations 2023	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845868
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Reactome Pathways 2014	1.0	null
obstructive lung disease	GWASdb SNP-Disease Associations	1.0	0.387926
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14941
decreased circulating interleukin-6 level	MGI Mouse Phenotype Associations 2023	1.0	null
regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Ixazomib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321909
NFKBID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19841
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
myd88	GeneRIF Biological Term Annotations	1.0	null
GTEX-W5X1-2526-SM-3GILC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10567
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
BTK	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.52716
specific developmental disorder	GWASdb SNP-Disease Associations	1.0	0.154998
PMC4290680__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153124_4_v_3_dsg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6614373__F2	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849527
regulation of nucleic acid-templated transcription	GO Biological Process Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H6-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TMMY-1226-SM-4DXT6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977117
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847736
Perturb_688_KD_ASAP2_SRP406127	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Imiquimod (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0683851
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.678
GTEX-T5JW-0426-SM-4DM7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08668
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETC-206_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0384611
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.850774
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TIA1_KO_GSE54418_265_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_Ensembl_that_KD_acts_upon_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
Pancreatitis	CTD Gene-Disease Associations	1.0	1.06479
GTEX-V955-1326-SM-4JBHR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30328
abnormal intercellular signaling peptide or protein level	MPO Gene-Phenotype Associations	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55314
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal cytokine secretion	MPO Gene-Phenotype Associations	1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977662
Immune System	Reactome Pathways 2024	1.0	null
Lung epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
Anorexia	CTD Gene-Disease Associations	1.0	1.45089
PMC3579143__F8	PFOCR Pathway Figure Associations 2023	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytokine Signaling in Immune system	Reactome Pathways 2024	1.0	null
Demyelinating Diseases	CTD Gene-Disease Associations	1.0	1.01852
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.25899
MAP2K3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0826-SM-32PMC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10876
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26527
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42223
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8058998__F1	PFOCR Pathway Figure Associations 2024	1.0	null
A549_G007-LK_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168247
blood vessel endothelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2403
Perturb_13679_KD_TFEB_SRP033784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
K562_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182691
Allergic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytokine-mediated signaling pathway	GO Biological Process Annotations 2023	1.0	null
RMGI	CCLE Cell Line Gene Expression Profiles	1.0	1.35827
TCF12	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
PMC4792926-ncomms10810-s3.xlsx-list_2_PHF20-dependent_E2_genes-gene_PHF20	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal immune cell physiology	MPO Gene-Phenotype Associations	1.0	null
regulation of rna metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15485
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Interferon regulatory factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.187
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12917
metaphyseal sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
inflammatory response	GO Biological Process Annotations 2023	1.0	null
GSE157050,GSE157051_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.271652
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121071
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6683136-41598_2019_47363_MOESM4_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_16_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14203
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95519
ARAF	Pathway Commons Protein-Protein Interactions	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	6.64348
intracellular part	GO Cellular Component Annotations 2015	1.0	null
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27117
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
PMC12882559-12894_2026_2046_MOESM2_ESM.docx-0-ZNF770_ZNF770	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39224
PMC3767435__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE159678_4_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP2K6	Pathway Commons Protein-Protein Interactions	1.0	null
Anemia	CTD Gene-Disease Associations	1.0	1.53772
Perturb_5588_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961473
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Demeclocycline_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0325354
toll-like receptor 2 signaling pathway	GO Biological Process Annotations 2015	1.0	null
Toll Like Receptor signaling(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01072
Irinotecan_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219434
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34071
CCDC174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7632
PMC3742913__F5	PFOCR Pathway Figure Associations 2023	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.33551
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164912
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3760_KD_TSG101_SRP325061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
plasmacytoid dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.468436
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18472
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979603
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
GSE233679_12_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862553
PMC3322338__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
PMC7827341__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1070-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MY-M12	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.74175
biomarker	GeneRIF Biological Term Annotations	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.205
lung disease	GWASdb SNP-Disease Associations	1.0	0.233539
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
calvarial osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.78799
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CEBPA-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
NVP-BHG712_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123522
mesenchymal	GeneRIF Biological Term Annotations	1.0	null
Sonidegib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0154042
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.21536
macrophage cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.175601
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25934
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
transferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044195
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7697665__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_3761_KD_VPS28_SRP325061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.7941
PMC8946535__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PC3	CCLE Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48585
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5637	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
PMC9550351__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
RCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46853
Blood vessel endothelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83536
Perturb_293_KO_GPX4_SRP255715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
NCI-H2135	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Doxorubicin (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237577
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3YQ-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFSD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13971
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.493745
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0585
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.765
ZNF713	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13673
NT5DC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09901
Neratinib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0185807
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22123
NCIH1339	CCLE Cell Line Gene CNV Profiles	1.0	1.4568
venetoclax_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0117401
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978152
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.733454
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.92882
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
253JBV	CCLE Cell Line Gene Expression Profiles	1.0	1.39779
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.054294
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.73637
Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.09373
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23449
Pralsetinib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260585
5-Azacytidine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0230154
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36476
Fusidic acid_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0111104
ETV1_01_35	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.67488
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TI-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978922
PMC5418219__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35216
mapk cascade	GO Biological Process Annotations 2015	1.0	null
abnormality of the middle ear	GWASdb SNP-Phenotype Associations	1.0	0.379728
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JE-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_knockout_301_GSE32224	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.45946
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComUP-List-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
abnormality of the forearm	GWASdb SNP-Phenotype Associations	1.0	0.60143
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.29256
Brain Lower Grade Glioma_LGG_TCGA-HT-7857-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07048
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03149
A549_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180191
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
ACT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3504
Carcinoma, Squamous Cell	CTD Gene-Disease Associations	1.0	1.46701
H2AK5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hyperlipidemias	CTD Gene-Disease Associations	1.0	1.19312
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.518742
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27836
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.810638
PMC5852877__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.53942
Perturb_9104_KD_KDM4C_SRP202026	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.48729
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Azithromycin (hydrate)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0228128
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.887313
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pulmonary tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
(R)-Verapamil (hydrochloride)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203308
GPR25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19679
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825876
8305C	CCLE Cell Line Gene Expression Profiles	1.0	1.36691
PMC8466445__F1	PFOCR Pathway Figure Associations 2024	1.0	null
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.208825
PMC5854649__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26652
death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
TLR4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84C-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262236
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
silenced	GeneRIF Biological Term Annotations	1.0	null
abnormality of the vertebral column	GWASdb SNP-Phenotype Associations	1.0	0.213497
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40435
abnormality of forearm bone	GWASdb SNP-Phenotype Associations	1.0	0.60143
EW8	DepMap CRISPR Gene Dependency	1.0	3.26904
Thymol_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282282
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MyD88 cascade initiated on plasma membrane	Reactome Pathways 2024	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.58733
phosphotransferase activity, alcohol group as acceptor	GO Molecular Function Annotations 2015	1.0	null
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9576445-IJG2022-9264555.nxml--Potential_targets_of_hsa-miR-16-5p_AND_hsa-miR-184_NOT_hsa-miR-15b-5p_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.845776
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-320b	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
MAP kinase activation in TLR cascade	Reactome Pathways 2014	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.34606
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Clonidine (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0413454
K562_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211133
CCZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68438
Prostate adenocarcinoma_PRAD_TCGA-EJ-5502-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rheumatic disease	GWASdb SNP-Disease Associations	1.0	0.442858
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.705
ECC4	DepMap CRISPR Gene Dependency	1.0	2.38298
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC5676564__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RSV_24Hour_19459069_GSE3397	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.79689
PMC10380530__F1	PFOCR Pathway Figure Associations 2024	1.0	null
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507269
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.719
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132468
PMC10061014-Table7.XLSX-C_vs_L-Table_S7a_Predicted_upstream_regulators_of_genes_showing_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
traf6irak2	GeneRIF Biological Term Annotations	1.0	null
colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123844
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tucidinostat_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146151
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.98209
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.935859
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6792-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06396
Inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.078
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-U412-0526-SM-3DB9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10461
developmental disorder of mental health	GWASdb SNP-Disease Associations	1.0	0.12814
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02929
PMC5571607__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-63-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2814006__F1	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Vestimentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
ACHN	CCLE Cell Line Gene Mutation Profiles	1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.928309
CHD1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-1.08445
receptormediated	GeneRIF Biological Term Annotations	1.0	null
Human aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
Pralsetinib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0509328
Larotrectinib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0139234
TFAP2C	ChEA Transcription Factor Targets	1.0	null
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
interleukin1rassociated	GeneRIF Biological Term Annotations	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-A47G-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71185
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Microphthalmia with limb anomalies	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
Signaling by Interleukins	Reactome Pathways 2024	1.0	null
BRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31789
KATOIII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC5650615__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Azithromycin (hydrate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0284279
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rosiglitazone_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0133969
PEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52399
ERBB2_knockdown_235_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.90325
GTEX-XPT6-0226-SM-4B65L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936247
Lung Injury	CTD Gene-Disease Associations	1.0	1.61224
PMC3976587__F7	PFOCR Pathway Figure Associations 2024	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Belumosudil_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0383181
WHSC1	ENCODE Transcription Factor Targets	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.278297
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978396
presenilindependent	GeneRIF Biological Term Annotations	1.0	null
Adenosine triphosphate	HMDB Metabolites of Enzymes	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-1.12038
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04487
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SW872	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.69631
SHSY5Y	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73633
Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173873_10_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09588
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A3L1-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163698
GSE178340_5_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.00386
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35403
PMC5593677__F2	PFOCR Pathway Figure Associations 2024	1.0	null
microrna146a	GeneRIF Biological Term Annotations	1.0	null
Toll-like Receptor Cascades	Reactome Pathways 2024	1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833142
Tamibarotene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Eosinophil Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40077
Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
activation of immune response	GO Biological Process Annotations 2015	1.0	null
Belumosudil (mesylate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120594
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.473627
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5390594__F2	PFOCR Pathway Figure Associations 2023	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neurodegenerative Diseases	CTD Gene-Disease Associations	1.0	1.06698
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE173873_8_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-1626-SM-48U26	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969953
abnormality of the cerebrum	GWASdb SNP-Phenotype Associations	1.0	0.260719
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE210476_2_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vaccinia virus (strain Copenhagen)	Virus MINT Protein-Virus Interactions	1.0	null
PMC6534778__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Valdecoxib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0287751
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40731
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38026
PMC3342348__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Estrone sulfate (potassium)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0144481
interleukin-12 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.002
regulation of canonical NF-kappaB signal transduction	GO Biological Process Annotations 2025	1.0	null
abnormal interleukin-6 secretion	MPO Gene-Phenotype Associations	1.0	null
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal circulating interleukin-6 level	MPO Gene-Phenotype Associations	1.0	null
Toll-Like Receptors Cascades	Reactome Pathways 2014	1.0	null
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.20526
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4951
CTCF_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3536146__F8	PFOCR Pathway Figure Associations 2024	1.0	null
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881729
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4447342__F2	PFOCR Pathway Figure Associations 2024	1.0	null
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-Duck_gene_name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6527596__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACA	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283245
PMC4199593__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
tlr	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-6216-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961961
primary motor cortex (area M1, area 4)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10048
PMC7544743__F1	PFOCR Pathway Figure Associations 2024	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
Adrenocortical carcinoma_ACC_TCGA-OR-A5JQ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
histiocytic lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297089
Nilotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
PMC5000685__F2	PFOCR Pathway Figure Associations 2024	1.0	null
defense response	GO Biological Process Annotations 2015	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-510	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
TOMM70A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PIK3R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12216
abnormality of limb bone morphology	GWASdb SNP-Phenotype Associations	1.0	0.60143
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
Everolimus_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0241201
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Systemic lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.22884
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal cortical bone morphology	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC7468443-Data_Sheet_2.xlsx-DEG_2h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.384324
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19729
hsa-miR-4793-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.35618
C99	DepMap CRISPR Gene Dependency	1.0	3.15626
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	1.0	2.95832
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7248557__F1	PFOCR Pathway Figure Associations 2024	1.0	null
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047471
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDH3A2	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.06054
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2968
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7817-01B-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
GTEX-XBED-1226-SM-4AT5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8249
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
A549_Danusertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0338094
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HOXD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76536
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14634
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3767435__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149943_2_v_3_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_42_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GATA3_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Th1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.097
Rheumatoid arthritis disease specific synovial fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
Perturb_7031_KD_Casz1_SRP038989	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.85789
Bone marrow-derived macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.908
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
toll-like receptor 9 signaling pathway	GO Biological Process Annotations 2015	1.0	null
VDR-23401126-LCL-AND-THP1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC4208300__F3	PFOCR Pathway Figure Associations 2024	1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35473
hsa-miR-519c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
Hydroxyfasudil_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244869
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.68266
Regulation of toll-like receptor signaling pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07433
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.160254
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.60196
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
immune response	GO Biological Process Annotations 2015	1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98999
PMC12410147-NIHMS2099518-supplement-3.xlsx-z-scores_DEGs_DGATi_LPS_vs_LPS-Z-scores_for_genes_differentially_expressed_when_comparing_DGATi_LPS_treatment_to_LPS_alone_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VDR-20736230-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228687
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834667
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.08
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49221
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU46	CCLE Cell Line Gene CNV Profiles	1.0	1.91497
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
Periodontitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
hemangioma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.311014
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of response to cytokine stimulus	GO Biological Process Annotations 2025	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118617,GSE118619_2_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cognitive impairment	GWASdb SNP-Phenotype Associations	1.0	0.578819
SMIM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11757
PMC7156293__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Cef cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24549
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6446
CHST12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44787
hsa-miR-4727-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Belumosudil_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205129
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50194
BAY1125976_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0317049
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5244336__F9	PFOCR Pathway Figure Associations 2023	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_53_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
IRAK3	Pathway Commons Protein-Protein Interactions	1.0	null
bacterial meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.471089
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trigeminal	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.20657
abnormality of the stapes	GWASdb SNP-Phenotype Associations	1.0	0.60143
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77845
SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.25513
Innate Immune System	Reactome Pathways 2014	1.0	null
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226106
Gallic acid_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0195699
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
MyD88 dependent cascade initiated on endosome	Reactome Pathways 2014	1.0	null
PMC8269088__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Radotinib_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148382
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242426
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8166-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SBI-0640756_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0273625
SLC9A3R1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Infectious disease	Reactome Pathways 2024	1.0	null
TFAP2C-20629094-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131404
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222283
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.05237
GSE211829_9_v_4_tafasitamab_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.178877
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
pituitary adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.238403
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.63274
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2785474__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.294
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988241
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Olanzapine_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206814
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4290680__F1	PFOCR Pathway Figure Associations 2024	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09838
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral blood mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.829
JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	Reactome Pathways 2024	1.0	null
OSC-19	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
SIRT4_KO_GDS4823_505_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
UBR1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
9-ING-41_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213101
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MR-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
activated TAK1 mediates p38 MAPK activation	Reactome Pathways 2024	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.248
Skin-cd1c-positive myeloid dendritic cell	Tabula Sapiens Gene-Cell Associations	1.0	0.123256
positive regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
SMAD4	ChEA Transcription Factor Targets	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.91895
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64423
hsa-miR-646	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
hsa-miR-3934	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09653
PMC3572906__F3	PFOCR Pathway Figure Associations 2024	1.0	null
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32566
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plasmacytoid dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.814
PMC4985245__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-OXRL-0726-SM-3NM9A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48476
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.24843
bronchial epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.112403
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5039587__F1	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.958077
Allopurinol_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0262898
SBC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.484
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046327
Ligustrazine_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.026468
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
A549_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130989
CAL62	CCLE Cell Line Gene CNV Profiles	1.0	1.80914
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8064355__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Peritoneal exudate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12308
Myocarditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
FLOT2	Pathway Commons Protein-Protein Interactions	1.0	null
Mifepristone	CTD Gene-Chemical Interactions	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.305026
GTEX-P44H-0326-SM-2XCES	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90285
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NF-kappaB p50/p65 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.838
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052297
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846006
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3461-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45935
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Measles	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mood disorder	GWASdb SNP-Disease Associations	1.0	0.335842
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20061
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
identical protein binding	GO Molecular Function Annotations 2015	1.0	null
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07956
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
16818636-TableS1	GeneSigDB Published Gene Signatures	1.0	null
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28063
response to interleukin-1	GO Biological Process Annotations 2015	1.0	null
PMC4292165__F1	PFOCR Pathway Figure Associations 2023	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	1.00386
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9648
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Idarubicin (hydrochloride)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180747
C2CD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54406
Liver	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.04325
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hematuria	CTD Gene-Disease Associations	1.0	1.31119
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV-2 Infection	Reactome Pathways 2024	1.0	null
FAHD1	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-3R-A8YX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8553822__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
NAMALWA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
GTEX-XXEK-0126-SM-4BRVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02931
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.879428
GSE173873_5_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.080812
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
ULK-101_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166965
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.592444
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1443_KO_Cd18_SRP376289	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.31026
SARS-CoV_24Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62598
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22646
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233954
PMC4799985__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Mubritinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.99
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZC3H11A_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05988
NCIH2196	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5498
Lymphoplasmacytic lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.631
Gallic acid_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0239038
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.98347
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.744
Tolcapone_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0275185
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
A549_Azacitidine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201491
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
fetal membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074819
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.912933
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.93138
regulation of cytokine-mediated signaling pathway	GO Biological Process Annotations 2015	1.0	null
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06813
Cowpox	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
Acquired immunodeficiency syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
Capivasertib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0187106
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11551338-pnas.2411189121.sd01.xlsx-AHR-Unnamed_0_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE211128_7_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4824131__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Oleic acid_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0302312
CCDC47	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25177
TAF7L-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_13245_OE_Med24_SRP201000	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.87539
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.986531
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
GEMIN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43431
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05322
PMC5952219__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE126621,GSE126920_1_v_4_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gammasecretase	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUW1-0126-SM-4BOOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833534
Idarubicin (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156707
NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
YTHDF2	Pathway Commons Protein-Protein Interactions	1.0	null
L-Thyroxine (sodium salt pentahydrate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244961
central	GeneRIF Biological Term Annotations	1.0	null
interleukin-1 receptor complex	GO Cellular Component Annotations 2015	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
lung epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.175834
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55505
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372237
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A6FZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-1126-SM-4DXUB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12412
LY96	Pathway Commons Protein-Protein Interactions	1.0	null
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.166
Erythromycin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0367346
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4977549__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-PWCY-1926-SM-3NB25	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982414
GSE196699_7_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QGP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215979
MYC	ChEA Transcription Factor Targets	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.236921
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.038064
unfolded	GeneRIF Biological Term Annotations	1.0	null
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0513843
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983504
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
LIN28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44312
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0999
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.843089
Meningeal Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fluvoxamine (maleate)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216328
YD38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46321
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KC-32-GO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219157
ZNF888	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85427
Interleukin-1 signaling	Reactome Pathways 2014	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Hesperidin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.036705
A549_Iniparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158372
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909744
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.00386
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05566
Homoharringtonine_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0433928
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125011_0_v_2_cd83_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein serine/threonine kinase activity	GO Molecular Function Annotations 2023	1.0	null
Zfp36l2_deficiency_GDS3574_153_mouse_E14.5 fetal liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24656
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55916
IL1 signaling	WikiPathways Pathways 2024	1.0	null
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65188
GTEX-PWN1-0726-SM-48TDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20411
NRARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47119
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35728
hsa-miR-520b	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15924
Infertility, Female	CTD Gene-Disease Associations	1.0	1.6249
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24387
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46538
LY2090314_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0217233
Eosinophil percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.02218
EL-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.764
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5430-01A-02R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66181
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202456
PMC4544004__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic pattern recognition receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
A549_Barasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190242
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64875
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_symbol_that_KD_acts_upon_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66958
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52281
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Talc_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0103663
abnormality of the uvea	GWASdb SNP-Phenotype Associations	1.0	0.260719
PMC5167032__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mL347	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
Smallpox	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
PMC6553925__F6	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ml-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.378372
ML218	DeepCoverMOA Drug Mechanisms of Action	1.0	0.69
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
MYOD1	ENCODE Transcription Factor Targets	1.0	null
IRF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04956
PMC4917669__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tuberculosis	KEGG Pathways 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0526-SM-4AD58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24679
CD95 death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.407
Berberine (chloride hydrate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0381867
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.51
BI-3406_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0176227
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39501
PELI1	Pathway Commons Protein-Protein Interactions	1.0	null
inflammatory response	GO Biological Process Annotations 2015	1.0	null
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849938
Estrone sulfate (potassium)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122859
Perturb_9102_KD_KDM3A_SRP202026	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.5354
PMC7398577__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_12861_KO_Clec4d_SRP282597	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81005
Perturb_14607_KO_SMAD4_SRP255626	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.3047
GTEX-S33H-1826-SM-4AD65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890539
PMC10645393-jci-133-169200-s102.xlsx-Table_S14_AR-V_DNA-PK_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-8470-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neratinib (maleate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141368
Brain Injuries	CTD Gene-Disease Associations	1.0	1.07163
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3069
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.198991
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061144
PMC6790574__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4W6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
PMC5579652__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Innate Immune System	Reactome Pathways 2024	1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
myd88irak4irak2	GeneRIF Biological Term Annotations	1.0	null
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0926-SM-4LVMK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884685
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43546
SNU869	CCLE Cell Line Gene CNV Profiles	-1.0	-2.86943
GSE223008_0_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61451
Atrophy	CTD Gene-Disease Associations	1.0	1.49096
SPI1	ChEA Transcription Factor Targets	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
Hepatitis	CTD Gene-Disease Associations	1.0	1.31
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00059
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.02774
PMC7578260__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Ranolazine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0252434
GTEX-S4P3-1526-SM-3K2AV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02366
H2AC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35833
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Protein kinase-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Larotrectinib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189245
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05407
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24399
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8910759__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-U8T8-2226-SM-3DB95	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00601
RMC-6236_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0160038
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.21148
PPARG	ChEA Transcription Factor Targets	1.0	null
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.989272
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4576153__F1	PFOCR Pathway Figure Associations 2024	1.0	null
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of transferase activity	GO Biological Process Annotations 2015	1.0	null
CDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39605
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Voriconazole_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0339337
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46002
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57559
AM095	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-0926-SM-2I5FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912976
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.049
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC128926__F2	PFOCR Pathway Figure Associations 2023	1.0	null
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
broadly	GeneRIF Biological Term Annotations	1.0	null
RAW-264.7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.817
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3514012__F5	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
lipopolysaccharide-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43737
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34267
PMC5549772__F2	PFOCR Pathway Figure Associations 2024	1.0	null
PMC4447342__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC84262__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE196962_4_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4UY-0926-SM-4AD6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44704
hsa-miR-524-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51F-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.424963
A549_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121302
hsa-miR-548am	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07539
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE195568_2_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170492
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12564
synovial tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.13153
Pravastatin (sodium)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237203
PMC9171412__F3	PFOCR Pathway Figure Associations 2024	1.0	null
SARS-CoV Infections	Reactome Pathways 2024	1.0	null
EX229_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0333635
Leukopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
PMC3521791__F6	PFOCR Pathway Figure Associations 2024	1.0	null
IKKalpha-IKKalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
RERFGC1B	CCLE Cell Line Gene CNV Profiles	1.0	2.15262
Toll Like Receptor 7/8 (TLR7/8) Cascade	Reactome Pathways 2014	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.94504
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07572
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.863341
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08345
GTEX-OXRO-0326-SM-33HBM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53534
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Stereocilium membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.727
Perturb_4010_OE_NFAT2_SRP388821	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.14198
sclerosis of humeral diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
positive regulation of canonical NF-kappaB signal transduction	GO Biological Process Annotations 2025	1.0	null
CHEMBL2431803	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
CDIPT	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ERK5-IN-2_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0286936
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58415
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	2.92071
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.838163
Weight Loss	CTD Gene-Disease Associations	1.0	2.12576
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.95039
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bergenin_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0323989
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837736
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hepatitis B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tgfbeta	GeneRIF Biological Term Annotations	1.0	null
CC-44-MG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249524
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.770266
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.541117
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
Ascites	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.728
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95193
peripheral blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.658272
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240342
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204178
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.02636
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PISD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17435
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170808
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37489
EOMES-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.86337
LFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30952
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_44_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54488
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69366
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cancer	GWASdb SNP-Disease Associations	1.0	0.066509
hsa-miR-490-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased circulating tumor necrosis factor level	MPO Gene-Phenotype Associations	1.0	null
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41238
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3136902__F1	PFOCR Pathway Figure Associations 2024	1.0	null
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60991
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17938
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bacterial-type flagellum filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA2	ChEA Transcription Factor Targets	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	2.08248
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Splenic marginal zone lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22339
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02954
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2031
PMC3821792__F2	PFOCR Pathway Figure Associations 2023	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057393
RK-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
hsa-miR-520a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15571_OE_circCSPP1_SRP286288	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.12461
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83959
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20303
stressed	GeneRIF Biological Term Annotations	1.0	null
COLO-783	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.93669
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.425726
Alveolar epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.114
colorectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276846
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
GATA-1_KD_GDS1245_81_mouse_megakaryocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8297548__F2	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-372	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.151703
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21664
Polycythemia Vera	DisGeNET Gene-Disease Associations	1.0	null
GSE135842_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Barasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142446
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A6G1-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.66392
PMC5852779__F2	PFOCR Pathway Figure Associations 2023	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-8321-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4345914__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_12184_KD_LATS1/LATS2_SRP065500	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.50809
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.917402
5637	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
IRAK2 mediated activation of TAK1 complex	Reactome Pathways 2014	1.0	null
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-X4EP-0526-SM-3P5YW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89191
PMC5450331__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peritoneal macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.484
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.06382
GSE232261,GSE232263_0_v_1_usf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of phalanx of finger	GWASdb SNP-Phenotype Associations	1.0	0.60143
CA-25-LR28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312454
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.24433
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0973
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-8_DEGs_RUNX1-OE_vs_control-Gene_Symbol_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64538
VPS26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44943
negative regulation of intracellular signal transduction	GO Biological Process Annotations 2025	1.0	null
S-Adenosyl-L-methionine (disulfate tosylate)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0199468
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47S-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Aprepitant_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258253
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.93294
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-599	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of upper limb bone	GWASdb SNP-Phenotype Associations	1.0	0.60143
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Everolimus_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0551694
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.27209
NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1908	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040865
Nolatrexed	DeepCoverMOA Drug Mechanisms of Action	1.0	0.79
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28398
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45527
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947141
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_24_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7993742__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF148	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00749
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.184853
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.035
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	1.0	1.00424
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55104
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
respiratory epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553286
IRAK2 mediated activation of TAK1 complex	Reactome Pathways 2024	1.0	null
abnormality of finger	GWASdb SNP-Phenotype Associations	1.0	0.60143
Vemurafenib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0427225
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.180694
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
PMC3742913__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZSWIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05912
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863456
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2829
Fetal_Intestine_Small	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.894797
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
GTEX-XGQ4-2226-SM-4AT4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01777
DNAJB12	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16534
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04332
hsa-miR-4326	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998149
PMC7069124__F4	PFOCR Pathway Figure Associations 2023	1.0	null
regulation of protein kinase activity	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	Reactome Pathways 2014	1.0	null
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Transcription factor AP-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.253
synovial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23011
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4394028__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rabies CVS-11_7day-Spinalcord_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.94238
PMC6382076__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Lung Injury	CTD Gene-Disease Associations	1.0	1.15425
immune system phenotype	MPO Gene-Phenotype Associations	1.0	null
substrate	GeneRIF Biological Term Annotations	1.0	null
16135802-Table1	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5126-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC2721684__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_15482_OE|KD_ERG|EWSR1_SRP075246	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.55386
hsa-miR-4768-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Medroxyprogesterone acetate_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180256
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206013
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.34169
SCGB3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44881
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OTULIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43221
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7838-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
AA-58-FJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402358
CTCF_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06793
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.232836
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26991
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_8_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_18_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.902985
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48173
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Reactome Pathways 2014	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7761-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.21148
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEWO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
nucleotide-binding oligomerization domain containing signaling pathway	GO Biological Process Annotations 2015	1.0	null
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADCK3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acetohexamide_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016779
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
aging	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE242333_0_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07071
leukopenia	GWASdb SNP-Phenotype Associations	1.0	0.710458
prednisolone_homo sapiens_gpl570_gse32962	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2BK12ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC3890654__F1	PFOCR Pathway Figure Associations 2024	1.0	null
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5227
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.09567
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67419
response to stress	GO Biological Process Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6157-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.237559
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36495
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_14329_KD_FOXK2_SRP318251	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Toll Like Receptor 4 (TLR4) Cascade	Reactome Pathways 2024	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Multiple Myeloma	CTD Gene-Disease Associations	1.0	1.19312
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fusidic acid_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256834
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08129
FLI1	ChEA Transcription Factor Targets	1.0	null
Adenosine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216925
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7805
PML	ENCODE Transcription Factor Targets	1.0	null
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary effusion lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
PMC4774101-13024_2016_87_MOESM3_ESM.xlsx-Table_S9-COMMON_DEGs_IN_AT_LEAST_3_OUT_OF_4_CONDITIONS_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I6-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2H5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22478
Poisoning	CTD Gene-Disease Associations	1.0	1.84517
Lung Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
TLR5	Pathway Commons Protein-Protein Interactions	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRIF-mediated TLR3/TLR4 signaling	Reactome Pathways 2014	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27984
urethral obstruction	GWASdb SNP-Phenotype Associations	1.0	0.60143
(R)-Verapamil (hydrochloride)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130605
transcription	GeneRIF Biological Term Annotations	1.0	null
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128642
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.14717
SDAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28705
H3K9ac_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.85656
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951868
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.852
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_189_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Isocorydine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.03336
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12/HEB-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
PERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06676
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15076
regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pentagastrin_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0325874
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFL-0826-SM-3MJG1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36637
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.38384
abnormality of the thorax	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC7432002__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837149
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_358_KD_SIRT5_SRP311327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.3494
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06749
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	1.00386
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.40732
Osteoporosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
intracellular signaling cassette	GO Biological Process Annotations 2025	1.0	null
measles	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.446935
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the clavicle	GWASdb SNP-Phenotype Associations	1.0	0.60143
THG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51996
ARL1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181208
PMC6955051__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.44599
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.368624
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRAF6 Mediated Induction of proinflammatory cytokines	Reactome Pathways 2014	1.0	null
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52544
cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.734217
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.402
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mature B-cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
PMC5852877__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.908
nucleus	GO Cellular Component Annotations 2015	1.0	null
lipopolysaccharide receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.98927
KNS60	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80392
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914806
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39131
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54506
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Japanese encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
hsa-miR-1256	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PMC5039188__F1	PFOCR Pathway Figure Associations 2023	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0726-SM-3NMCR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4206
abnormal eye morphology	GWASdb SNP-Phenotype Associations	1.0	0.11781
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.08196
PMC12146336-Data_Sheet_1.pdf-145-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Leukemia, Myeloid, Acute	HuGE Navigator Gene-Phenotype Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75424
colorectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263327
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.837
A549_SRT2104_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251324
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0413032
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838924
PMC6384427__F2	PFOCR Pathway Figure Associations 2024	1.0	null
NVP-BHG712_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0540892
Chronic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Npas4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.9263
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
abnormality of the lower urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.379728
GSE195568_2_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bisoprolol (hemifumarate)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136849
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
downstream	GeneRIF Biological Term Annotations	1.0	null
generalized osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383563
hsa-miR-302a	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.505763
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5698-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver bud hepatic cell_Liver_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE178532_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Toll Like Receptor 2 (TLR2) Cascade	Reactome Pathways 2024	1.0	null
regulation of response to stress	GO Biological Process Annotations 2015	1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosome membrane	GO Cellular Component Annotations 2023	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
GSE186483_1_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441426
aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.130451
Pentagastrin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248233
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IL1R1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84855
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
endosome membrane	GO Cellular Component Annotations 2025	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.052
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Th17 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.328
GSE149943_2_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.15523
PMC3923659__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glomerulosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
Everolimus_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0362216
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70832
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20127
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10986
ARMC10	Pathway Commons Protein-Protein Interactions	1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.558856
FAM115A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3594740__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC7100912-EMS85677-supplement-Suppl__Tables_1_8.xlsx-Table_6-Supplementary_Table_6_Nanostring_gene_expression_profiling_of_memory_T_cells_transduced_with_BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1437	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_3261_KD_TFAM_SRP089927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.244
Bone marrow-derived dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.237
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bergenin_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152445
PMC3342043__F1	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
increased circulating alkaline phosphatase level	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_1080_OE_ZBED2_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413037
Endothelial cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365017
MFE296	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964054
KANK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1507
GSE221742,GSE221743_1_v_2_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NHBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
Bacterial sepsis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Macrophage cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.874
PMC8927970__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8851354-Table_5.xlsx-FUS-DDIT3_ruxo_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_both_FUS-DDIT3_and_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
SLC38A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06272
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CENPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54799
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4822134__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52281
Lung adenocarcinoma_LUAD_TCGA-44-2668-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_12_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WM88	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61157
Prostate adenocarcinoma_PRAD_TCGA-HC-8262-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EX229_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0351172
A549_ZM 447439_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248915
PMC6208316__F2	PFOCR Pathway Figure Associations 2023	1.0	null
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116232
urinarybladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.968752
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06854
HCC1359	CCLE Cell Line Gene Expression Profiles	1.0	1.52424
abnormal neutrophil cell number	GWASdb SNP-Phenotype Associations	1.0	0.710458
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26632
PMC4957230__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMURF1	Hub Proteins Protein-Protein Interactions	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.844216
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61319
asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.522273
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889615
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NOP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40077
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Perturb_13508_OE_Cd274_SRP234708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.78833
GSE130956_0_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.962277
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7716795__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
IQSEC1	Pathway Commons Protein-Protein Interactions	1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
TP53BP1_KD_GSE54268_669_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149091
REST	ENCODE Transcription Factor Targets	1.0	null
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-0926-SM-4DXUV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5814
Alveolar macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.483
PMC3923659__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Leiomyoma	CTD Gene-Disease Associations	1.0	1.01928
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OE-E6/E7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
Cytokine Signaling in Immune system	Reactome Pathways 2014	1.0	null
abnormality of the genital system	GWASdb SNP-Phenotype Associations	1.0	0.097185
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882407
PMC6959184__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC4576153__F1	PFOCR Pathway Figure Associations 2023	1.0	null
LEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15471
ikappab kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.2708
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28236
A549_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144967
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
increased bone mineral density	GWASdb SNP-Phenotype Associations	1.0	0.60143
heart muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.09567
GSE100316_3_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
GSE166767_1_v_2_ctcfl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSU	CCLE Cell Line Gene CNV Profiles	1.0	1.86231
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-1026-SM-4LMK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965168
PMC6966427__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31389
NCIH526	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45234
revealing	GeneRIF Biological Term Annotations	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042357
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-A7TX-01A-33R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL4189 (USP19)	NURSA Protein Complexes	1.0	null
Mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.261
BE2-M17	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.44545
Herpes simplex	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
JVM2	CCLE Cell Line Gene Expression Profiles	1.0	1.81509
Ritonavir_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021185
bronchus	HPA Tissue Protein Expression Profiles	1.0	1.00386
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.783487
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
I-kappaB/NF-kappaB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
polycythemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.296931
Rifaximin_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204487
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.84587
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_22_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.11148
ATP12A	Pathway Commons Protein-Protein Interactions	1.0	null
ITFG3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5977009__F1	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of signal transduction	GO Biological Process Annotations 2025	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0744
abnormal leukocyte physiology	MPO Gene-Phenotype Associations	1.0	null
A549_SRT3025 HCl_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250107
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50434
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Docetaxel_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166308
C8orf76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46988
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.9942
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21133
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
Pain	CTD Gene-Disease Associations	1.0	1.25183
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_24_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930718
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3759_KD_VPS28_SRP325061	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
FK866	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.73
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312595
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35453
PMC3297025__F1	PFOCR Pathway Figure Associations 2023	1.0	null
bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.081033
abnormality of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	0.454773
RISC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.432
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235017_1_v_0_uba52_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-2426-SM-48FF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75556
PMC5825991__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.890002
MCRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11368
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83349
SARS-dORF6_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.27118
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Elagolix sodium_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234708
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29419
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.65204
Massive Hepatic Necrosis	CTD Gene-Disease Associations	1.0	1.21011
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
i-kappab kinase/nf-kappab signaling	GO Biological Process Annotations 2015	1.0	null
urethral stenosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2015	1.0	null
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64861
hs27	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NR1H3	ChEA Transcription Factor Targets	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_15_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
cancer	GAD High Level Gene-Disease Associations	1.0	0.295739
Bimatoprost_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155819
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03385
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89132
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.5143
PMC7056731__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885415
abnormal interferon secretion	MPO Gene-Phenotype Associations	1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69963
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069267
MRPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06695
CHD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918059
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-Thyroxine (sodium salt pentahydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238669
Crohn's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
Renal epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
AP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13548
INPP5D	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6677_KD_ROBO3_ERP130576	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-49-6767-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Abemaciclib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0379663
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28777
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YE-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14092_KD_FOXD3_SRP051544	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833314
diffuse mesangial sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
patchy osteosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25317
abnormal professional antigen presenting cell physiology	MPO Gene-Phenotype Associations	1.0	null
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Resting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.465
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35143
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825148
Calu-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.121
SETDB1	ChEA Transcription Factor Targets	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040754
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_65_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
LOMEGUATRIB	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.63896
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
Integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.354
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
rectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.13122
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Arthritis, Rheumatoid	CTD Gene-Disease Associations	1.0	1.04684
AT7519_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164995
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6683-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDE10A_KO_GDS4542_292_mouse_hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_12271_KD_ANK1_SRP189259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.2465
histone	GeneRIF Biological Term Annotations	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8851354-Table_2.xlsx-Genes_reg_by_FUS-DDIT3-Supplementary_Table_2_Genes_significantly_regulated_by_FUS-DDIT3_expression_in_HT1080_cells_adjusted_p-value_0_05_and_log2_Fold_change_1_or_-1_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250394
ETV5_01_304	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.82767
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26A-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pralsetinib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.018604
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the costochondral junction	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC3421232__F5	PFOCR Pathway Figure Associations 2023	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939986
endothelial cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51734
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RH30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76338
protein dimerization activity	GO Molecular Function Annotations 2015	1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MyD88-dependent toll-like receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU387	CCLE Cell Line Gene CNV Profiles	1.0	1.9786
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02954
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-302b	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
response to organic substance	GO Biological Process Annotations 2015	1.0	null
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PDK1_knockout_80_GSE26290	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.436317
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84879
PMC7911386__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.508
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04691
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.640023
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_11670_KD_RELA_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.31054
T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145323,GSE145324_9_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-0826-SM-4E3J1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13062
increased circulating alkaline phosphatase level	IMPC Knockout Mouse Phenotypes	1.0	null
KIJK	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12909
PMC6581583__F3	PFOCR Pathway Figure Associations 2023	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3552145__F10	PFOCR Pathway Figure Associations 2024	1.0	null
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
Macroglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06841
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Belinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208455
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03974
CORO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34813
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34828
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1157_KO_Myc_SRP150708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.5229
decreased inflammatory response	MPO Gene-Phenotype Associations	1.0	null
Blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RAD21	ChEA Transcription Factor Targets	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06409
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5097-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.96481
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040714
Adenine_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208879
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.12478
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4371
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91731
L-Eflornithine (monohydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0318874
GTEX-WEY5-1026-SM-4LMK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17636
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pitolisant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.215
STAT1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04627
IOSE-29 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.6473
positive regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC10242447-mmc2.xlsx-TI_DEGs-Table_S1_TIGs_Comparison_between_each_trained_monocyte_sub-population_T3m_LPS_with_monocytes_T0_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-373	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
(R)-Verapamil (hydrochloride)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0178829
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.064942
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875679
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_11_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164815
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153232
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93371
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.525
PMC3521791__F6	PFOCR Pathway Figure Associations 2023	1.0	null
Rheumatic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178798
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09772
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DJ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5883109__F9	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990732
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2181
P2URK562	DepMap CRISPR Gene Dependency	1.0	3.64526
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937628
ANKRD13A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01651
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20787
PJA1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3712200-584604.f1.pdf-12-ZNF721_ZNF721	Rummagene Transcription Factor Associations 2026	1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
19139136-TableS2	GeneSigDB Published Gene Signatures	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-WK-A8XX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11630_KD_GPRC5D_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.86509
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10911
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RVH421	DepMap CRISPR Gene Dependency	1.0	2.06244
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
NR3C1-23031785-PC12-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978396
PMC7762867__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE131649_2_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rimonabant_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0313674
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884628
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-1126-SM-48FEB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61786
GSE126463_4_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Econazole_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00748827
hsa-miR-466	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Ubiquitin conjugating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.494
PMC9505944__F2	PFOCR Pathway Figure Associations 2024	1.0	null
COGN305	DepMap CRISPR Gene Dependency	1.0	3.38392
Psoriatic arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.69708
HCC366	CCLE Cell Line Gene Expression Profiles	1.0	1.55872
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350245
Toll Like Receptor 5 (TLR5) Cascade	Reactome Pathways 2014	1.0	null
ZNF414	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33213
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572418
GTEX-RM2N-0826-SM-48FD3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01283
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0217989
JIMT1	CCLE Cell Line Gene CNV Profiles	1.0	1.42822
PMC8452524__F1a	PFOCR Pathway Figure Associations 2024	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07275
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149010_0_v_4_dars2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.16735
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831805
Perturb_451_KD_EMS_SRP171802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.05877
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.61805
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.07406
PF 04447943	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
NCIH510	DepMap CRISPR Gene Dependency	1.0	2.11825
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26359
response to chemical	GO Biological Process Annotations 2015	1.0	null
PMC6781720__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_15035_KD_Ctcflos_SRP311201	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.98036
postcentral gyrus, left, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20323
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22339
bronchial epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248683
AZD2858_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204396
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.96906
HB-54-ZC59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313959
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067308
PMC10852255-pone.0297872.s004.xlsx-LPS_UPstream-Upstream_Regulator_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-GH-A9DA-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5490603__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866844
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
Hepatitis C	DisGeNET Gene-Disease Associations	1.0	null
cytosolic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058553
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CADM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02078
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13238
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30246
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8071_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mifepristone_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202009
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTC549	DepMap CRISPR Gene Dependency	1.0	2.16822
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE120336_0_v_2_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859709
GTEX-WRHU-0226-SM-3MJFV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12419
PMC3208682__F1	PFOCR Pathway Figure Associations 2023	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.833619
PC-3_[JPC-3]	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934972
PMC3144045__F1	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Signal transduction through IL1R	WikiPathways Pathways 2024	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR751	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45752
abnormality of the metaphyses	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.50624
Docetaxel_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0227721
Celecoxib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0287587
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.367
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30147
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263739
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZC3H11A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R2-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148692,GSE148695_7_v_4_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-JV-A5VE-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196962_2_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
697	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86092
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1078_OE_ZBED2_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.66758
cell part	GO Cellular Component Annotations 2015	1.0	null
decreased acute inflammation	MPO Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71D-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-30	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.86449
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5754
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.794591
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250696
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EI-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Familial Mediterranean fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
17699775-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66014
GTEX-U8XE-1226-SM-4E3HN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61469
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171645
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A677-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1340_KD_EMP1_SRP367805	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.5959
Pancreatic adenocarcinoma_PAAD_TCGA-H6-8124-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1437	CCLE Cell Line Gene Mutation Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48381
EOMES	ChEA Transcription Factor Targets	1.0	null
GTEX-S33H-0626-SM-2XCBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937838
SAMHD1	Pathway Commons Protein-Protein Interactions	1.0	null
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0091
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062594
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08379
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859366
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Reactome Pathways 2024	1.0	null
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977662
myelofibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.303059
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902966
GSE242049_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305812
PMC3438932__F7	PFOCR Pathway Figure Associations 2024	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30703
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Daidzin_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213846
Ataluren_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0344031
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31205
NACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7326
Fluvoxamine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162548
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PP-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244959
transcriptional	GeneRIF Biological Term Annotations	1.0	null
Perturb_16523_KO_Ahr_SRP318414	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.15072
GSE120336_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
d431eirak2	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PK-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
PAX5	ENCODE Transcription Factor Targets	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6480119__F9	PFOCR Pathway Figure Associations 2023	1.0	null
SNU213	CCLE Cell Line Gene Expression Profiles	1.0	1.51084
PMC6953314__F3	PFOCR Pathway Figure Associations 2023	1.0	null
abnormality of radial diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_1hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2085
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09566
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01709
decreased circulating interleukin-6 level	MPO Gene-Phenotype Associations	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.80565
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.29502
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
PMC4026397__F4	PFOCR Pathway Figure Associations 2023	1.0	null
canonical NF-kappaB signal transduction	GO Biological Process Annotations 2025	1.0	null
Omeprazole (sodium)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00774477
TPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16921
HHV-8_72Hour_18587055_GSE6489	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.02379
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
I-kappaB kinase/NF-kappaB signaling	GO Biological Process Annotations 2023	1.0	null
RPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.645
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MTDH	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11298
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890381
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11647707-JHA2-5-1201-s004.pdf-11-MBD3_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401627
Perturb_2881_KD_YAP1/WWTR1_SRP201886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.4702
PMC7398577__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE221327_1_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSEN1	Pathway Commons Protein-Protein Interactions	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76399
NLRX1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5584_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
Lidocaine (hydrochloride)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0378156
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.531541
PMC2785474__F2	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-4512	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Docetaxel_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265212
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TE-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.993222
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68811
j-774 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.317679
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.702626
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2533023__F5	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276145
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
ADGRE5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36882
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5629438__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCK81	CCLE Cell Line Gene Mutation Profiles	1.0	null
bone marrow-derived macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.526744
PMC4305100__F3	PFOCR Pathway Figure Associations 2024	1.0	null
HEC251	CCLE Cell Line Gene Mutation Profiles	1.0	null
Th2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.092
abnormality of facial skeleton	GWASdb SNP-Phenotype Associations	1.0	0.379728
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NG25_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258565
CTCF_GM12801_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-M8-A5N4-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Birth Weight	HuGE Navigator Gene-Phenotype Associations	1.0	null
machinery	GeneRIF Biological Term Annotations	1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TLR9	Pathway Commons Protein-Protein Interactions	1.0	null
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Synovium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.299
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0266
SK-N-DZ	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.68361
Abiraterone2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
PMC9317022__F1	PFOCR Pathway Figure Associations 2024	1.0	null
UBAC2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6966713__F5	PFOCR Pathway Figure Associations 2024	1.0	null
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37237
GSE132759_4_v_2_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
emsa	GeneRIF Biological Term Annotations	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
JHUEM2	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68758
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.827595
Disease	Reactome Pathways 2024	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
planum polare, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.950789
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
unexpected	GeneRIF Biological Term Annotations	1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BFTC-905	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TMEM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28275
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Chronic lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
Lung adenocarcinoma_LUAD_TCGA-55-6986-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Balsalazide (sodium hydrate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175566
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-574-ZSCAN1_ZSCAN1	Rummagene Transcription Factor Associations 2026	1.0	null
variant	GeneRIF Biological Term Annotations	1.0	null
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal macrophage physiology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Tolmetin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0424163
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.62916
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73864
RYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60746
ZMPSTE24	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
TRAF6-mediated induction of TAK1 complex within TLR4 complex	Reactome Pathways 2024	1.0	null
PMC4799985__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174701_4_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111102,GSE111105_3_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-TPRX1_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_TPRX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2837270__F8	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.595599
Perturb_11568_OE_SIX4_SRP166969	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.49447
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thrombosis	CTD Gene-Disease Associations	1.0	1.01625
GTEX-T2IS-0226-SM-32QPH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30237
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3655
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978561
abnormality of the choroid	GWASdb SNP-Phenotype Associations	1.0	0.333941
STAT4	ChEA Transcription Factor Targets	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24014
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ixazomib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268678
Movement Disorders	CTD Gene-Disease Associations	1.0	1.37075
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77959
diaphyseal sclerosis of the upper limbs	GWASdb SNP-Phenotype Associations	1.0	0.60143
XIAP	Pathway Commons Protein-Protein Interactions	1.0	null
ADP	HMDB Metabolites of Enzymes	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285843
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
mRNA_MYOD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HEC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.59734
CTCF_CH12.LX_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
Glioma	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90524
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Amsacrine_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184557
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
4EGI-1_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209126
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.41291
5637	CCLE Cell Line Gene Expression Profiles	1.0	3.40795
von hippel-lindau disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.55945
ELK1	ENCODE Transcription Factor Targets	1.0	null
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plasma protein metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60518
uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.231448
GTEX-PWCY-1326-SM-48TCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10814
L-Thyroxine (sodium salt pentahydrate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.022008
regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
Perturb_4402_KO_STING1_SRP191307	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Everolimus_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0337489
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE100316_5_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0926-SM-4AT4U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986656
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045445
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2505
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47451
Pitavastatin (Calcium)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00955974
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12152148-41420_2025_2541_MOESM3_ESM.xlsx-AR-IP-DHT_peak-gene-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4133513__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
decreased sensitivity to induced morbidity/mortality	MPO Gene-Phenotype Associations	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4595011-pgen.1005555.s001.xlsx-MITF_UP-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRC_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_17595_KD_MPI_SRP355455	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.1451
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96991,GSE97117_4_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
GSE203308_1_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83101
SSR4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4917669__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein homodimerization activity	GO Molecular Function Annotations 2015	1.0	null
mesangial abnormality	GWASdb SNP-Phenotype Associations	1.0	0.60143
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.520731
Hypertrophy	CTD Gene-Disease Associations	1.0	1.60758
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lidocaine (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0305998
SARS-CoV-1 Infection	Reactome Pathways 2024	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Severe COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prostate	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059326
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.974
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MyD88-independent TLR4 cascade	Reactome Pathways 2024	1.0	null
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123979
TE11	CCLE Cell Line Gene CNV Profiles	1.0	1.418
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.872808
GSE148692,GSE148695_2_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MyD88 cascade initiated on plasma membrane	Reactome Pathways 2014	1.0	null
PMC11356641__F4	PFOCR Pathway Figure Associations 2024	1.0	null
RHOT1	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosomal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-N7MT-0326-SM-48TDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968327
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52582
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal interferon-alpha secretion	MPO Gene-Phenotype Associations	1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268872
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91031
HAUS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89622
negative regulation of sequence-specific dna binding transcription factor activity	GO Biological Process Annotations 2015	1.0	null
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6329
abnormality of the male genitalia	GWASdb SNP-Phenotype Associations	1.0	0.213497
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
KMBC2	CCLE Cell Line Gene Expression Profiles	1.0	1.74724
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of protein serine/threonine kinase activity	GO Biological Process Annotations 2015	1.0	null
Lung Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.20816
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Ras guanyl-nucleotide exchange factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.451
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
sclerosis of skull base	GWASdb SNP-Phenotype Associations	1.0	0.60143
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Econazole_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191902
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.867
KLKB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1139
RBMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79339
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20215513-TableS3	GeneSigDB Published Gene Signatures	1.0	null
SOCS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75971
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Immune System	Reactome Pathways 2014	1.0	null
BRPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16473
increased density of long bones	GWASdb SNP-Phenotype Associations	1.0	0.60143
Elongin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the skull	GWASdb SNP-Phenotype Associations	1.0	0.409473
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tolllike	GeneRIF Biological Term Annotations	1.0	null
PMC6491485-41467_2019_9913_MOESM4_ESM.xlsx-DEGs_Fig_3D_E-Comparison_SS-BAL_DC2_3_vs_LPS-BAL_DC2_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6146-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47259
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S33H-0826-SM-4AD5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827324
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059864
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TRAF6	Hub Proteins Protein-Protein Interactions	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175482
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23449
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1915 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
JUND	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
Peretinoin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0157685
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507579
PMC8914318__F7	PFOCR Pathway Figure Associations 2024	1.0	null
TNFAIP3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8713033__F6	PFOCR Pathway Figure Associations 2024	1.0	null
Doxycycline (monohydrate)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00926324
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lonafarnib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0229586
PDIA5	Pathway Commons Protein-Protein Interactions	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.00148
organelle	GO Cellular Component Annotations 2015	1.0	null
TRAF2	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CINCA Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12448905-vlaf042_supplementary_data.pdf-4-CDX1_CDX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13805
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.928309
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NF-kappaB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.837
A549_Ofloxacin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166656
critical	GeneRIF Biological Term Annotations	1.0	null
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-548ae	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
abnormal genital system morphology	GWASdb SNP-Phenotype Associations	1.0	0.112134
NB17	DepMap CRISPR Gene Dependency	1.0	5.10033
TCS ERK 11e	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.73
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16585_KO_Bmal1_SRP217335	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.30403
SPI1	ENCODE Transcription Factor Targets	1.0	null
Perturb_1356_OE_LINC00665_SRP350264	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1876	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
linkage	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040784
GTEX-S95S-1626-SM-2XCDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10178
SUDHL8	DepMap CRISPR Gene Dependency	1.0	4.4244
Signaling by Interleukins	Reactome Pathways 2014	1.0	null
PMC8403095__F1	PFOCR Pathway Figure Associations 2024	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.904152
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8714953__F1	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.910093
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5192315__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.119
lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064508
MORCPR	DepMap CRISPR Gene Dependency	1.0	2.51742
PMC2799977__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930453
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Busulfan_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203701
toll-like receptor 10 signaling pathway	GO Biological Process Annotations 2015	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal induced morbidity/mortality	MPO Gene-Phenotype Associations	1.0	null
tendon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109108
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HYOU1	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-DX-A8BQ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148252_2_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Clofarabine_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0352808
A549_Tazemetostat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0311944
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
PMC4544004__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC2168342__F7	PFOCR Pathway Figure Associations 2024	1.0	null
atp binding	GO Molecular Function Annotations 2015	1.0	null
Everolimus_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0310727
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219276
sclerosis of finger phalanx	GWASdb SNP-Phenotype Associations	1.0	0.60143
GTEX-QV44-1825-SM-447CF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22777
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26533
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signal transduction through il1r	Biocarta Pathways	1.0	null
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.995311
ARNT_01_240	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.36858
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02141
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039487
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6761_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87814
colonic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.281423
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal diaphysis morphology	GWASdb SNP-Phenotype Associations	1.0	0.60143
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6826-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.76636
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NUCKS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CBM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
abnormality of the globe	GWASdb SNP-Phenotype Associations	1.0	0.11781
UACC812	CCLE Cell Line Gene Expression Profiles	-1.0	-2.11499
abnormality of the humeral diaphysis	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC8851354-Table_6.xlsx-Ruxolitinib_reg_STAT3-bound-Supplementary_Table_6_Genes_regulated_by_ruxolitinib_that_are_STAT3_targets_in_at_least_two_cell_lines_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH2	CCLE Cell Line Gene Expression Profiles	1.0	1.62215
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30174
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.866505
Inflammation	CTD Gene-Disease Associations	1.0	2.30751
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150861
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915338
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4225-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
Fulvestrant_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203682
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.83775
Lipoic acid_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0347247
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
component	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XI-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-0426-SM-4DM5Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01141
Pemigatinib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0327816
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55091
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873426
hsa-miR-520d-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PSMA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52871
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36495
PMC7716795__F1	PFOCR Pathway Figure Associations 2024	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRAF6	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2382
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853049
transferase activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
irak4	GeneRIF Biological Term Annotations	1.0	null
blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.955
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255099
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
Perturb_15361_KO_Tfap4_SRP212619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81733
Perturb_16963_OE_RAB44_SRP305964	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74851
Fusidic acid_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203192
Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.15695
abnormal bone structure	GWASdb SNP-Phenotype Associations	1.0	0.454773
OVCA-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
bronchial disease	GWASdb SNP-Disease Associations	1.0	0.794591
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881647
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung Diseases	CTD Gene-Disease Associations	1.0	1.6169
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3902
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscle-mast cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.193999
PER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01474
YTHDF1	Pathway Commons Protein-Protein Interactions	1.0	null
U-937 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.138
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
lymphopenia	GWASdb SNP-Disease Associations	1.0	0.794591
regulation of immune system process	GO Biological Process Annotations 2015	1.0	null
decreased tumor necrosis factor secretion	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59254
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88765
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWN1-1426-SM-48TDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879146
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-1426-SM-4DM5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15573
rectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262986
regulation of sequence-specific dna binding transcription factor activity	GO Biological Process Annotations 2015	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21968
Skin-macrophage	Tabula Sapiens Gene-Cell Associations	1.0	1.70179
toll-like receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Enhanceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
phenotype	GeneRIF Biological Term Annotations	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62593
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285292
response to cytokine	GO Biological Process Annotations 2025	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
Eczema	DisGeNET Gene-Disease Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-503	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0995
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1805
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Roxadustat_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132386
MOCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10746
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15279
GJD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77993
Balsalazide (sodium hydrate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0288084
PMC4487811-mmc3.xlsx-siRE_enriched_geneLists-siRE_occupancy_pattern_gene_lists_after_RUNX1_ETO_knock_down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.954742
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883198
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medroxyprogesterone acetate_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0344705
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
PMC3572906__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PMC2856775__F1a	PFOCR Pathway Figure Associations 2023	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03892
PMC5101451__F1	PFOCR Pathway Figure Associations 2024	1.0	null
decreased susceptibility to induced morbidity/mortality	MGI Mouse Phenotype Associations 2023	1.0	null
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140741
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14391
sclerosis of hand bone	GWASdb SNP-Phenotype Associations	1.0	0.60143
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81822
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5WG-1726-SM-4LMI5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28724
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	2.11353
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAL1_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923366
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ire1	GeneRIF Biological Term Annotations	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pharmacogenomic	GAD High Level Gene-Disease Associations	1.0	0.293278
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5743-01A-21R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endogenous TLR signaling	PID Pathways	1.0	null
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Interleukin-1 signaling	Reactome Pathways 2024	1.0	null
Trimetrexate_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0381271
hsa-miR-150	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
12471243-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tumor necrosis factor receptor superfamily complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37613
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37557
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
(R)-Verapamil (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245156
GTEX-QV31-0626-SM-447C5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982107
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6508-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Death	CTD Gene-Disease Associations	1.0	1.26856
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.80793
Hypercholesterolemia	CTD Gene-Disease Associations	1.0	1.02596
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30705
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.556467
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.33352
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.040593
GTEX-SIU7-0526-SM-3NM8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02143
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4C_BATF3_downreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC6390351__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869484
Heart Diseases	CTD Gene-Disease Associations	1.0	1.57306
connective tissue disease	GWASdb SNP-Disease Associations	1.0	0.102162
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057012
PMC5945810__F2	PFOCR Pathway Figure Associations 2023	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.901212
agranulocytosis	GWASdb SNP-Disease Associations	1.0	0.814557
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4T-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.640933
Brain Lower Grade Glioma_LGG_TCGA-CS-4941-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLPP_KO_GSE40207_380_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230754
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.41856
DOLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03813
Interferon regulatory factor 7 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.732
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07112
Perturb_14562_KD_SULF2_SRP361678	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lymphoma	GWASdb SNP-Phenotype Associations	1.0	0.690896
OCIM1	CCLE Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7025-01A-12R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Reactome Pathways 2024	1.0	null
PLPP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15631
PMC4026397__F4	PFOCR Pathway Figure Associations 2024	1.0	null
PMC4133513__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Gallic acid (hydrate)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0319925
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24443
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242199_6_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Torkinib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221815
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SESTD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bestatin (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00483186
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.236627
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
clavicular sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
PMC4668848__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
implicates	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940629
UBC13-UEV1A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.883
NDUFA10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.99719
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11542
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10219
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
regulation of immune response	GO Biological Process Annotations 2015	1.0	null
regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
lefthanded	GeneRIF Biological Term Annotations	1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.82585
HCV JFH1_120Hour-Huh7_5_1_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.40222
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.894
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24973
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
A549_Hesperadin_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0488937
ZFTRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25525
GSE86507,GSE86509_7_v_9_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD2	Hub Proteins Protein-Protein Interactions	1.0	null
jnk cascade	GO Biological Process Annotations 2015	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927933
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BI-3406_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0386544
scleroderma	GWASdb SNP-Disease Associations	1.0	0.442858
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLP8	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.970927
positive regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
GTEX-U412-0826-SM-3DB9K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972249
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148483
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GO-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4QR-1026-SM-2I5GP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41441
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
PMC4453536__F8	PFOCR Pathway Figure Associations 2023	1.0	null
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vilanterol_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0133157
PMC12311841-CTM2-15-e70424-s001.pdf-16-EMX2-like_EMX2	Rummagene Transcription Factor Associations 2026	1.0	null
Adult T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
PMC8469693__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Toll-like receptor 2-Toll-like receptor 6 protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.914
PMC4887650__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Dabrafenib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0336074
Perturb_808_KD_LAP2alpha_SRP224617	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.084
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
negative regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
rt4	HPA Cell Line Gene Expression Profiles	1.0	1.42849
19808870-ST1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_8373_OE_AC093797.1_SRP344034	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.7433
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the ear	GWASdb SNP-Phenotype Associations	1.0	0.295751
ASF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68952
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
necrosis	GeneRIF Biological Term Annotations	1.0	null
Trifluridine_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321917
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907537
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
GSE173873_2_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8733666-DataSheet1.xlsx-Table_S6-Supplementary_Table_6_IRRGs_significantly_related_to_OS_of_PDAC_patients_in_the_PACA-AU_cohort_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4718
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TG-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03798
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978396
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
MZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.993531
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.24721
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ipatasertib_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.022347
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myd88-independent toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.123
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09649
abnormality of the vertebrae	GWASdb SNP-Phenotype Associations	1.0	0.60143
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132576
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.832
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.300682
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
systemic scleroderma	GWASdb SNP-Disease Associations	1.0	0.700141
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048185
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070181
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19419
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12301
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.929652
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7143-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of DNA-binding transcription factor activity	GO Biological Process Annotations 2023	1.0	null
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06253
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-0926-SM-48FDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912545
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
depression	GWASdb SNP-Phenotype Associations	1.0	0.387391
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162084,GSE162085_2_v_6_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CD14	Pathway Commons Protein-Protein Interactions	1.0	null
PMC2175514__F5	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5499-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ranolazine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00453526
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20077526-TableS4	GeneSigDB Published Gene Signatures	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6955051__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Longissimus lumborum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
placenta	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.02354
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Clofarabine_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256697
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63599
stress-activated mapk cascade	GO Biological Process Annotations 2015	1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07517
Uterus-endothelial cell	Tabula Sapiens Gene-Cell Associations	1.0	16.961
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2097
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22075
chorion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109371
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834876
protein homodimerization activity	GO Molecular Function Annotations 2023	1.0	null
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28549
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0411
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.237559
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
activation of mapk activity	GO Biological Process Annotations 2015	1.0	null
Ligustrazine_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185775
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCID - Severe combined immunodeficiency_Lung Tissue_GSE3414	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-3.93627
Gallic acid_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0339002
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.935665
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZM-0626-SM-4DXTV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57745
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.019074
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.854411
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal cell-mediated immunity	MPO Gene-Phenotype Associations	1.0	null
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057007
Malotilate_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0305338
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ABCB6	Pathway Commons Protein-Protein Interactions	1.0	null
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0831
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.77
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7252
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129022
PMC7674197__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PYCARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73455
GTEX-R53T-1526-SM-48FEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03123
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02461
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
morphological abnormality of the middle ear	GWASdb SNP-Phenotype Associations	1.0	0.60143
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.039
PMC7248557__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.714
PMC8058998__F1	PFOCR Pathway Figure Associations 2023	1.0	null
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28404
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03148
negative regulation of nf-kappab transcription factor activity	GO Biological Process Annotations 2015	1.0	null
Bursa of Fabricius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
IKBKB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
Human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391373
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MTARC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37142
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	1.0	3.00405
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58438
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.33405
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IN-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Rapamycin_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0319851
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YC-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33994
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.738706
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPAST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05525
Acute Myeloid Leukemia_LAML_TCGA-AB-3012-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2955
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.531484
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3705591__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Lapatinib ditosylate_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208351
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.36128
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plasma membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.301
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Malotilate_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140807
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.70876
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A5QV-01A-22R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_17349_KO_Rora_SRP298165	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.15925
GSE161295_2_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S100A9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.467
caco-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268482
A549_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012621
diaphyseal sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
HEK-293ET cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
AQ-390/43364023	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tomivosertib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232182
icSARS CoV_48Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.66383
PMC5854649__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC2799977__F2	PFOCR Pathway Figure Associations 2023	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Embryo Loss	CTD Gene-Disease Associations	1.0	1.28241
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14342
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45967
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.343829
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of movement	GWASdb SNP-Phenotype Associations	1.0	0.289975
PMC4867367__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20456
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.2393
MyD88:Mal cascade initiated on plasma membrane	Reactome Pathways 2014	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.00386
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_16525_KO_Ahr_SRP318414	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.16559
8-Hydroxyquinoline_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.014981
PMC4420468__F6	PFOCR Pathway Figure Associations 2023	1.0	null
Ulcerative Colitis	DisGeNET Gene-Disease Associations	1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFA9	Pathway Commons Protein-Protein Interactions	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
chorionic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159418
Perturb_9163_KD_Shp2_SRP351122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.42958
Apalutamide_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0295543
Metaplasia	CTD Gene-Disease Associations	1.0	1.25682
Perturb_5571_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61218
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.082
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4115
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06803
rectum	HPA Tissue Protein Expression Profiles	1.0	1.00386
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
calu-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.651777
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187522
GSE210476_9_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244113
RPSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76554
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37238
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.942513
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.889442
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29803
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Juvenile rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
GET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09568
GSE209698_2_v_1_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
bsc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
astroglial	GeneRIF Biological Term Annotations	1.0	null
anomaly of the upper limb diaphyses	GWASdb SNP-Phenotype Associations	1.0	0.60143
protein heterodimerization activity	GO Molecular Function Annotations 2025	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_3_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.18034
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.945037
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Glioblastoma	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SIRT4_KO_GDS4823_30_mouse_hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_263_KO_GPX4_SRP255715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Mebendazole_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0174449
hsa-miR-302e	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
SNU119	CCLE Cell Line Gene Mutation Profiles	1.0	null
Myeloid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
kinase1	GeneRIF Biological Term Annotations	1.0	null
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE165579_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMURF1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.81958
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6534778__F2	PFOCR Pathway Figure Associations 2023	1.0	null
protein serine/threonine kinase activity	GO Molecular Function Annotations 2015	1.0	null
IQCB1	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-4J-AA1J-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	1.0	1.36755
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.12892
PMC5000685__F2	PFOCR Pathway Figure Associations 2023	1.0	null
UACC893	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05188
PMC9414397__F4	PFOCR Pathway Figure Associations 2024	1.0	null
ASIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53069
PMC7468443-Data_Sheet_5.xlsx-LPS_2h_over_6h-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Microglial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.996
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XV7Q-0426-SM-4BRVN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16101
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.691
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.711164
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.95111
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
interleukin-1 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.834138
cell surface toll-like receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.186087
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.85261
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41015
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20329
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6752_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.73285
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SAEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34228
TLR2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.17714
Mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.231
PMC3976587__F7	PFOCR Pathway Figure Associations 2023	1.0	null
abnormal circulating cytokine level	MPO Gene-Phenotype Associations	1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38885
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-302c	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
GSE129244_0_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.831771
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7752859__F15	PFOCR Pathway Figure Associations 2024	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97132
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.600881
ILF3-29590119-K562-HUMAN-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Doxycycline (monohydrate)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01816
EW8	CCLE Cell Line Gene CNV Profiles	1.0	1.6305
RAD21	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66766
PMC3342043__F1	PFOCR Pathway Figure Associations 2023	1.0	null
inflammatory response	GO Biological Process Annotations 2025	1.0	null
PMC7982415__F2	PFOCR Pathway Figure Associations 2023	1.0	null
organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041171
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69065
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06749
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.852835
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13236
GSE226259_0_v_1_scd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIA1_KO_GSE54418_261_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.513802
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9937
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased circulating tumor necrosis factor level	MGI Mouse Phenotype Associations 2023	1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44632
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1876	CCLE Cell Line Gene Mutation Profiles	1.0	null
regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.115256
AD-06-OB47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243044
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.16833
reveals	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
demonstrate	GeneRIF Biological Term Annotations	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29689
PMC9687478__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC5450331__F1	PFOCR Pathway Figure Associations 2023	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3131135__F1	PFOCR Pathway Figure Associations 2024	1.0	null
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.25348
TET1	ChEA Transcription Factor Targets	1.0	null
osteosclerosis of the ulna	GWASdb SNP-Phenotype Associations	1.0	0.60143
Nasal lavage fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
PMC2668232__F5	PFOCR Pathway Figure Associations 2024	1.0	null
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.41735
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IRAK1	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM24_knockout_298_GDS3087	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.70115
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BICR31	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
outer CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00204
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rutin (trihydrate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0291877
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.47776
GTEX-X4EO-0926-SM-3P5Z2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870048
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0290176
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3250_KD_RBM38_SRP091017	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.14646
TEAD4	ChEA Transcription Factor Targets	1.0	null
PMC2922045__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Neratinib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01809
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911033
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.932576
Flagellate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.023
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCBL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
Interleukin-17 signaling	Reactome Pathways 2024	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945537
response to cytokine	GO Biological Process Annotations 2023	1.0	null
HEP3B217	CCLE Cell Line Gene Expression Profiles	1.0	1.42638
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.889613
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
anion binding	GO Molecular Function Annotations 2015	1.0	null
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Interferon regulatory factor 5 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.471
Synovial tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
signal transduction by phosphorylation	GO Biological Process Annotations 2015	1.0	null
PMC5549772__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.258917
hsa-miR-4429	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
Encorafenib_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189782
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.946501
endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063287
LB-100_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282524
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267012
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rheumatoid arthritis disease specific synovial tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13061
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Mastitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tucatinib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0380368
PMC4595011-pgen.1005555.s001.xlsx-MITF_UP-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5676564__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.816
positive regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Reactome Pathways 2024	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	2.142
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042664
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40138
Vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WRNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044027
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04022
more	GeneRIF Biological Term Annotations	1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
IkappaB kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.601
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7684
HMCB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56596
Monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.23
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.464
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39462
MyD88 dependent cascade initiated on endosome	Reactome Pathways 2024	1.0	null
BRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05412
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15189_KD_TP63_SRP056637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PEG10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NFK9-1526-SM-3LK7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23944
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.946499
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045263
MTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20805
Bimatoprost_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00973235
BEN	CCLE Cell Line Gene CNV Profiles	1.0	1.50678
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.4167
IKBKG	Pathway Commons Protein-Protein Interactions	1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-A4VJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32467
GSE173873_12_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vagina	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9182
protein heterodimerization activity	GO Molecular Function Annotations 2015	1.0	null
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241356
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NLRP3 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.706
HNF4A	ChEA Transcription Factor Targets	1.0	null
PMC7108734-pone.0230884.s004.xlsx-GHs_with_RELA_TFBS_and_DMR-Gene_Mapped_To_GH_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99884
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23828
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00742
A549_ITSA-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169377
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05742
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
Skin-cd141-positive myeloid dendritic cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.166917
PMC4097957__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Toll Like Receptor 10 (TLR10) Cascade	Reactome Pathways 2024	1.0	null
PMC7646980__F10	PFOCR Pathway Figure Associations 2023	1.0	null
MFE-296	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.888079
regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
NKX2-1_01_66	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.64027
Hypertension	CTD Gene-Disease Associations	1.0	1.65687
immune system process	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
response to interleukin-1	GO Biological Process Annotations 2025	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.901857
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29058
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.912355
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.906008
Rhinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
PMC7911386__F2	PFOCR Pathway Figure Associations 2024	1.0	null
intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.927703
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chronic obstructive pulmonary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45508
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRSF11	Pathway Commons Protein-Protein Interactions	1.0	null
STING complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.622
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234849
GSE173873_12_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7069124__F4	PFOCR Pathway Figure Associations 2024	1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53136
HSD17B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22625
site	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-150	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4118962__F1	PFOCR Pathway Figure Associations 2024	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-1126-SM-4BRVS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34979
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16069
Sapanisertib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224862
59m	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.145
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0795
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.163244
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183319
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4107957__F1	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Parasitic helminthiasis infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.79135
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36487
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7056731__F2	PFOCR Pathway Figure Associations 2024	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8372757__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal tumor necrosis factor secretion	MPO Gene-Phenotype Associations	1.0	null
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
diffuse cerebral sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
NKIRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69131
endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cytokine-mediated signaling pathway	GO Biological Process Annotations 2015	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068289
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12229841-Table2.xlsx-6mo_NS_vs_6mo_LPS-Negative_logFC_up_at_non-stimulated_Postive_logFC_up_after_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Norepinephrine (hydrochloride)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0308507
Rectum adenocarcinoma_READ_TCGA-EI-6511-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1	ChEA Transcription Factor Targets	1.0	null
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15406
SIRT4_KO_GSE56321_391_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE203308_8_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274616
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34954
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.262
Glioblastoma multiforme cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.28303
hsa-miR-4320	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PMC4097957__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Bergenin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216012
Colorectal Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IgA immunoglobulin complex, circulating	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.501
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
nobox_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.182547
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1819
PMC7763461__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TIA1_KO_GSE54418_267_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hsa-miR-520d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Irinotecan_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0303491
MDAMB436	CCLE Cell Line Gene Expression Profiles	1.0	1.6953
Levobupivacaine (hydrochloride)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134672
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6802116-41467_2019_12517_MOESM5_ESM.xlsx-Sheet1-D9_8_GNF2-SERPINB5_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
time	GeneRIF Biological Term Annotations	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Synovial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
PMC7205036__F11	PFOCR Pathway Figure Associations 2023	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.312971
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09069
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the posterior segment of the eye	GWASdb SNP-Phenotype Associations	1.0	0.196352
abnormality of forebrain morphology	GWASdb SNP-Phenotype Associations	1.0	0.260719
JAK1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5883109__F9	PFOCR Pathway Figure Associations 2023	1.0	null
AR_01_278	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59092
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24999
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARPP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69559
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.824986
TEAD4_01_151	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.89565
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6906-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6614373__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
S100A8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.529
Perturb_1736_OE_NHD13_SRP068420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.91445
positive regulation of signaling	GO Biological Process Annotations 2015	1.0	null
regulation of rna biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Irinotecan_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0127303
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
J558L cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
PMC6480119__F9	PFOCR Pathway Figure Associations 2024	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19676
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
neutropenia	GWASdb SNP-Disease Associations	1.0	0.814557
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cortical sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.60143
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22718
Vaccinia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
TLR3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Polymeric IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
SLC16A1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10887283__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5106-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
u87	HPA Cell Line Gene Expression Profiles	1.0	0.919227
abnormal interleukin secretion	MPO Gene-Phenotype Associations	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.60526
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893587
PMC7288929-aging-12-103203-s002..xlsx-upregulated_by_BCL6-TargetID_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3929246__F1	PFOCR Pathway Figure Associations 2024	1.0	null
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276891
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
point	GeneRIF Biological Term Annotations	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25335
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
abnormality of lymphocytes	GWASdb SNP-Phenotype Associations	1.0	0.690896
GSE210580_5_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-REY6-0426-SM-2TF5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17916
OPA1	Pathway Commons Protein-Protein Interactions	1.0	null
Perindopril	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216933
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Trihydroxyisoflavone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GTEX-O5YV-1026-SM-3LK72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09836
hsa-miR-548aj	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Ramelteon	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Perturb_15978_KO_Tsga8_SRP254760	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.50471
Baicalin_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.020653
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22872
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19399
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-323b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052412
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP3K7	Pathway Commons Protein-Protein Interactions	1.0	null
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068366
HS821T	CCLE Cell Line Gene Mutation Profiles	1.0	null
SCC-25 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.16903
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862291
Rabies CVS-11_7day-Brain_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.77308
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.912409
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
OVISE	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.10813
PMC6953314__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Toll Like Receptor 5 (TLR5) Cascade	Reactome Pathways 2024	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
20067540-Table3	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hodgkin's lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897593
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.10849
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.39247
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7873566__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5343938__F1	PFOCR Pathway Figure Associations 2024	1.0	null
WM2664	DepMap CRISPR Gene Dependency	1.0	2.30548
PMC8306625__F1	PFOCR Pathway Figure Associations 2024	1.0	null
DDX46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14252
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63569
interleukin-12 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
tonsil	HPA Tissue Gene Expression Profiles	1.0	1.16686
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CCC5	DepMap CRISPR Gene Dependency	1.0	3.34044
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192771_2_v_1_mt1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	1.0	2.6884
external encapsulating structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.300682
abnormal hematopoietic system physiology	MPO Gene-Phenotype Associations	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52935
HSOS1	DepMap CRISPR Gene Dependency	1.0	2.57267
PMC7432002__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Crizotinib (hydrochloride)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231359
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82829
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4151153__F2	PFOCR Pathway Figure Associations 2024	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42188
Memory Disorders	CTD Gene-Disease Associations	1.0	1.30911
AZD2858_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122626
Chloro-L-alanine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04532
GTEX-OXRN-0526-SM-2I5EN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26713
GHITM	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34547
inferior temporal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88576
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
PMC4922528__F2	PFOCR Pathway Figure Associations 2023	1.0	null
activation of protein kinase activity	GO Biological Process Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6464-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121722
Afatinib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249455
Perturb_1079_OE_ZBED2_SRP235000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3091668__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT4-19710469-TH1 cell mouse-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_5572_KO_NFKBIA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.0814
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15703_KD_JMJD1A/AGE_SRP353924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC4219345-1471-2121-14-52-S4.xlsx-BORIS_6dN-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.236921
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0904
PMC5390594__F2	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40483
GSE179974_3_v_2_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070416
interleukin-1-mediated signaling pathway	GO Biological Process Annotations 2015	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5739
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPR120_KO_GDS4830_414_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8I9-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_34_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Crizotinib (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130496
Extrinsic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
RNPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97338
18358739-Table1b	GeneSigDB Published Gene Signatures	1.0	null
viral integration complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.41143
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.177775
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74885
Cinacalcet_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185605
Synoviocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.197
CA-074	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
NCIH1092	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33548
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03287
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856578
JHOC5	CCLE Cell Line Gene Expression Profiles	1.0	2.65264
ZC3H12A	Pathway Commons Protein-Protein Interactions	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11746
A549_SRT3025 HCl_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123859
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999483
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15002
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.930066
regulation of protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
ED-14-GQ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452363
MAP kinase activation	Reactome Pathways 2024	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7303083__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Ipatasertib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220364
cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.330213
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.257671
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53281
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4822134__F1	PFOCR Pathway Figure Associations 2023	1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-63-ENSG00000170345_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
Hemolysis	CTD Gene-Disease Associations	1.0	1.21435
tendon sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121476
Microprocessor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.088
Trifluridine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164503
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_8_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12229841-Table2.xlsx-BL_NS_vs_BL_LPS-Negative_logFC_up_at_non-stimulated_Postive_logFC_up_after_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
PMC6305442-Table_1.docx-0-IKZF1_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitination	GeneRIF Biological Term Annotations	1.0	null
TUBB8	Pathway Commons Protein-Protein Interactions	1.0	null
colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111751
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.60105
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2C-20629094-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38343
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48395
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHUK	Pathway Commons Protein-Protein Interactions	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45217
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48346
hsa-miR-320a	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
PMC8554124-DataSheet2.XLSX-34-RFX3_RFX3	Rummagene Transcription Factor Associations 2026	1.0	null
protein modification process	GO Biological Process Annotations 2025	1.0	null
RUNX1-22343733-KASUMI1-HUMAN-PERIPHBLOOD-AML	ChEA Transcription Factor Targets 2022	1.0	null
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1442
meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.185313
Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073745
Coelomocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
PMC6491485-41467_2019_9913_MOESM4_ESM.xlsx-DEGs_Fig_3D_E-Comparison_LPS-BAL_DC2_3_vs_HC_blood_DC_2_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9374760__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE182854_2_v_3_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20411
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.944
endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49039
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96991,GSE97117_3_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15007
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19354
PMC3705591__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832132
ChIP_REST_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.987878
bronchial epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.107322
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hyperactivity	GWASdb SNP-Phenotype Associations	1.0	0.560832
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27311
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849738
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Viral Infection Pathways	Reactome Pathways 2024	1.0	null
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909123
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5108-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Benproperine (phosphate)_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0249024
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942428
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
acute myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088994
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.164146
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_Abexinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111268
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
within	GeneRIF Biological Term Annotations	1.0	null
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-merged_Gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2852602__F2	PFOCR Pathway Figure Associations 2023	1.0	null
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.072859
trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081497
PMC6695670__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
posttranscriptional	GeneRIF Biological Term Annotations	1.0	null
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11375
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45136
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-359-NCOA1_NCOA1	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of protein kinase activity	GO Biological Process Annotations 2015	1.0	null
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16887
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6928094-395_2019_765_MOESM6_ESM.xlsx-DEGs_AR11_vs_AR7-List_of_differentially_expressed_genes_in_AR11_vs_AR7_Negative_value_means_down-regulation_in_AR11_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267236
PMC7762867__F1	PFOCR Pathway Figure Associations 2023	1.0	null
kinase activity	GO Molecular Function Annotations 2015	1.0	null
Periodontal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.119561
GT3TKB	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
RMC-6236_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0425142
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0360656
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
PMC2903975__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Myeloid dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
Neratinib (maleate)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0300109
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NOVA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22622
KCIMOH1	CCLE Cell Line Gene Expression Profiles	1.0	2.05409
BFTC905	CCLE Cell Line Gene Mutation Profiles	1.0	null
CLPP_KO_GSE40207_396_mouse_Muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-ARGFX_UP-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_up_to_an_FPKM_of_at_least_2_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
FGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80951
Lymphoproliferative syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2497
PMC2731164__F7	PFOCR Pathway Figure Associations 2024	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tazemetostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168457
Pitavastatin (Calcium)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00835415
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sclerosis of foot bone	GWASdb SNP-Phenotype Associations	1.0	0.60143
Burkitt lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Kaposi's sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
n18	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4420468__F6	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191154
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348524
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-2426-SM-4BRV8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844582
Cytarabine (hydrochloride)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00986206
PMC8615041__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Rheumatoid arthritis disease specific fibroblast-like synoviocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.86633
GATA3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWOO-1226-SM-48TCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907155
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
J-774 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.33966
OP-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31405
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.909293
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.575154
A549_ITSA-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.019329
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPMI-8866	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Autoimmune Diseases	CTD Gene-Disease Associations	1.0	1.01249
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FECH	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137653_2_v_3_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3547332__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241274
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.990782
PMC7432002__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney Neoplasms	CTD Gene-Disease Associations	1.0	1.03752
POTEH	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of myeloid leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.207563
Blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Pentagastrin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0337564
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04882
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4364059__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A817-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCH 530348	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
Radotinib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226116
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29504
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WOFL-0126-SM-3MJG2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00706
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CSTF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08203
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.999096
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KBTBD3	Pathway Commons Protein-Protein Interactions	1.0	null
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.706402
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
occipito-temporal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00538
PMC9088131-13073_2022_1051_MOESM2_ESM.xlsx-Dura_Fibro_PC-GO_BP_regulation_of_cell_population_proliferation_Ex_CD55_HMOX1_FOSL1_regulation_of_DNA_binding_Ex_LIF_NME1_TXN_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8674309__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6433273-pone.0214296.s009.xlsx-Table_C-S3_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_6_hours_of_LPS_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Structural Pathway of Interleukin 1 (IL-1)(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11836325-41467_2025_56634_MOESM8_ESM.xlsx-gene_table_NGS5844-Supplementary_Data_6_Gene_targets_lost_in_resistant_cells_upon_FOSL1_knockdown_and_their_corresponding_hallmark_pathway_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04774
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.906794
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1526
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP3_cds_exp_up-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Eosinophil percentage of granulocytes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
RH00511	DeepCoverMOA Drug Mechanisms of Action	1.0	0.67
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC6491485-41467_2019_9913_MOESM4_ESM.xlsx-DEGs_Figure_2C_D-Comparison_LPS-BAL_CD14_CD16_MP_vs_HC_blood_classical_monocytes_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GAMG	CCLE Cell Line Gene Expression Profiles	1.0	2.39135
epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Large_Intestine-neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	-0.143703
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.540706
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.824013
HOXB7-26014856-BT474-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07289
Pneumonia	CTD Gene-Disease Associations	1.0	1.32399
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49136
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254312
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.858
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.889355
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sulfisoxazole_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.030206
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946978
19605494-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
increased total body fat amount	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-WEY5-1126-SM-4LMIE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871565
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98649
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
synovium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129291
Perturb_1706_KD_Rad21_SRP132608	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
abnormal blood cell physiology	MPO Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7596-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Quisinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162762
Lipopolysaccharides	CTD Gene-Chemical Interactions	1.0	null
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875268
vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BT16	DepMap CRISPR Gene Dependency	1.0	5.52931
abnormal chemokine level	MPO Gene-Phenotype Associations	1.0	null
cellular response to interleukin-1	GO Biological Process Annotations 2025	1.0	null
MZ7-mel	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.16728
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
16288205-GeneTable3	GeneSigDB Published Gene Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7590-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.918416
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.090115
PMC11615365-41467_2024_54246_MOESM4_ESM.xlsx-RT4-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of NF-kappaB transcription factor activity	GO Biological Process Annotations 2023	1.0	null
TAB2	Pathway Commons Protein-Protein Interactions	1.0	null
Imiquimod (hydrochloride)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00666301
COLO849	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48393
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4087
abnormal protein level	MPO Gene-Phenotype Associations	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40453
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6588
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04781
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
SELENOO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72883
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24482
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LTN1	Pathway Commons Protein-Protein Interactions	1.0	null
Toll Like Receptor 3 (TLR3) Cascade	Reactome Pathways 2024	1.0	null
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Extrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
OPM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54459
Toll Like Receptor TLR1:TLR2 Cascade	Reactome Pathways 2014	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
innate	GeneRIF Biological Term Annotations	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
decreased susceptibility to endotoxin shock	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891455
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051434
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297447
GTEX-X8HC-0226-SM-4E3K1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3274
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of neutrophils	GWASdb SNP-Phenotype Associations	1.0	0.390094
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.940923
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70252
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15762
POLR2A	ENCODE Transcription Factor Targets	1.0	null
KASUMI2	CCLE Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Azithromycin (hydrate)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0253788
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM28_knockout_302_GSE32224	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76017
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMSCTR	DepMap CRISPR Gene Dependency	1.0	2.07095
GSE173873_12_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of canonical NF-kappaB signal transduction	GO Biological Process Annotations 2025	1.0	null
ETC-206_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295124
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.15201
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.046346
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144685
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC2922045__F1	PFOCR Pathway Figure Associations 2023	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.56646
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17824
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.569546
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paclitaxel_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184835
Toll Like Receptor 3 (TLR3) Cascade	Reactome Pathways 2014	1.0	null
PMC7982415__F2	PFOCR Pathway Figure Associations 2024	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983816
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4720-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2841148__F6	PFOCR Pathway Figure Associations 2023	1.0	null
SEC61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57501
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukemia	HuGE Navigator Gene-Phenotype Associations	1.0	null
TAL1_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal appendicular skeleton morphology	GWASdb SNP-Phenotype Associations	1.0	0.507984
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.742744
PMC2533023__F5	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-4799-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
RT11284	DepMap CRISPR Gene Dependency	1.0	2.59491
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35458
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10296711__F8	PFOCR Pathway Figure Associations 2024	1.0	null
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068654
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14834_KD_Scr_SRP017110	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
VCB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
GSE211829_9_v_1_tafasitamab_human	RummaGEO Drug Perturbation Signatures	1.0	null
short tibia	IMPC Knockout Mouse Phenotypes	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAGED1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26129
Methotrexate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0108678
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875597
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
protein heterodimerization activity	GO Molecular Function Annotations 2023	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BSC-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFXL1	Pathway Commons Protein-Protein Interactions	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6158
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.51936
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03959
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Calcinosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
HS852T	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1349_KD_UBC9_SRP153825	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4XK-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Ofloxacin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151072
promoter	GeneRIF Biological Term Annotations	1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.482817
GSE121198,GSE129779_0_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bosentan (hydrate)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.025066
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.535409
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00345
PMC7752859__F15	PFOCR Pathway Figure Associations 2023	1.0	null
Cytarabine (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.030912
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nasal cavity disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
BD-69-XG81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244604
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6147-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12169532-pone.0325700.s010.xlsx-Table_S4-Table_S4_List_of_genes_that_upon_knockdown_KD_led_to_transcriptional_signitures_similar_to_the_input_DEG_set_of_CRC_or_LIHC_and_their_KEGG_enrichment_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5945810__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07433
Ripoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115146
GOTO	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.95267
GSE202587_1_v_2_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.915829
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207832_1_v_0_usp22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.073672
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.92254
T3M4	CCLE Cell Line Gene Mutation Profiles	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2594
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.503366
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10553