association	dataset	threshold value	standardized value
PMC6463957__F5	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K92428232_GSK-461364_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.42266
ICC3	DepMap CRISPR Gene Dependency	1.0	3.77085
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
horizontal nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01087
YDJC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00834518
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841686
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GJB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781486
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39136
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.20842
CRCGN017_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0066
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
Magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0143
GTEX-Q734-1626-SM-48U1B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27182
BRD-K73397362_Purmorphamine_A673_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATF2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653959
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.890757
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
breast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063782
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09903493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49847
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GR-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89371
JHH4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.80937
PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
HOXB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68515
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02058
Cytoplasmic vesicle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PSMD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59942
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1355
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4TI-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21651
FRAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054556
LASV_FML29 _4hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.34732
NCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70518
SOBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614558
16849537-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_4302_KO_Serpine1_SRP179032	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.67972
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
NDUFS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0086209
BRD-K55869732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31872
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66361
FABP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78243
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.26021
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856365
CDK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587786
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21011
Pericardial Effusion	CTD Gene-Disease Associations	1.0	1.09011
NECTIN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104207
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21741
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4436
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03126
FDFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2566
Perturb_15037_KD_Eif2ak3_SRP201230	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.86751
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41620124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07525
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
DNAJC5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679081
OB granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14961
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8127234-12885_2021_8319_MOESM2_ESM.docx-0-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
RANGRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2551
mammary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123306
ovary_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.829684
Lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
hsa-miR-4330	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-S4UY-1426-SM-4AD6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19667
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Immunoglobulin subtype 2	InterPro Predicted Protein Domain Annotations	1.0	null
HT1197	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84352
CYB561D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98696
BRD-K63068307_ZSTK-474_HS578T_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13850_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KDM3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19628
BRD-K33272502_DG-041_SW480_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06184
Lung squamous cell carcinoma_LUSC_TCGA-77-8138-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DAPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43076
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43868
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
DLX5_OE_GDS4577_345_mouse_Otic vesicle derived 2B1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0432
BRD-K52075040_-666_A673_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Optic Nerve Diseases	CTD Gene-Disease Associations	1.0	1.07447
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.0894
GTEX-P78B-2226-SM-3P5ZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0754
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10657
BRD-K30488928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75575
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8652
POMC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34934
BPHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27657
KMT2E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00760365
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04344
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC116	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552051
CDH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00778307
FRMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37724
BRD-K37798499_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K24156250_NCGC00182393-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92941354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20559
BRD-K30849099_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0341
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43365
DMS79	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57126
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0426-SM-2TC65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868189
PMC2276341__F3	PFOCR Pathway Figure Associations 2023	1.0	null
cell surface	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.238478
BRD-K78323315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03572
GSE179880_8_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.87859
Perturb_13522_KD_Pbrm1_SRP333303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
FOXP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79554
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0988
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24559
GSE151119_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
oval paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15658
BRD-K48911375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19683
CDC42SE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396454
Perturb_805_KO_Trim28_ERP125317	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.43948
OR5B21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00783226
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
Perturb_163_KD_RAC1_SRP387923	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.293
Cytoplasmic side of lysosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.284
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69526
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.688
PEO4	DepMap CRISPR Gene Dependency	1.0	7.09564
ARMC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18335
MEX3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80532
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10022
SNCA_KO_GDS4153_445_mouse_Striatum - 21 month	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RCBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33828
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.936686
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.46711
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49103536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15562
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6016-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5586_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.9446
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1439
BRD-K14821540_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MOCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66678
KCNN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006002
ZNF257	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97295
BRD-K81418486_vorinostat_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76694128_DCC-2036_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
an3ca	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GTEX-XV7Q-1626-SM-4BRWC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5578
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
NUP210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06454
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13658
DMS153	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86791
E2F7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00741052
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC38A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31017
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
DDX39B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00747161
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55902
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.46961
SLC25A32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72709
BRD-K83509924_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06403
BRD-K46373671_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIK3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67045
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41859756_-666_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7284
NANOG	ChEA Transcription Factor Targets	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.48761
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9608
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04677
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K91470977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08338
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27485
Lung adenocarcinoma_LUAD_TCGA-44-7672-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BLM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565749
DNMT3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00428398
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79090631_CGP-60474_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWN1-2426-SM-48TDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41368
BRD-K41895714_AS-605240_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52293
BRD-K53417444_OTSSP167_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21680192_mitoxantrone_MCF10A_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PLAGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45673
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30651
BACE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687102
BRD-K47582411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2393
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22924
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889316
TIA1_KO_GSE54418_265_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25222
CRCGN016_MCF10A.TP53.M_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78084
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.943333
CDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77329
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GPR37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40885
BRD-K39503511_MK-0591_HT29_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
long radius	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-TKQ2-0926-SM-4DXU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23291
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08345
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08774
Lung squamous cell carcinoma_LUSC_TCGA-46-3766-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34601
TAL1_erythroblast_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Diabetic Nephropathy_Renal Tissue_GSE1009	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.536422
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672331
Main olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41159
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55266
Perturb_17802_KO_ZNF675_SRP305529	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54636
GSE231648_0_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MO-1526-SM-4DM57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37508
CHRNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.705
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.09
BHLHA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53303
KIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0207915
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
fetus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K13534347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44196
TO175T	CCLE Cell Line Gene Expression Profiles	1.0	2.20619
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.99223
ID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666572
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54633
BRD-K13662825_dinaciclib_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CPXCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95052
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7831-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0126-SM-48TZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01392
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05484
Prostate adenocarcinoma_PRAD_TCGA-HC-7081-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE113106_3_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.895484
BRD-K51278788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35567
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K96239538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00776
CD80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558687
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03931
BRD-K12539581_NOCODAZOLE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ERBB2_knockdown_232_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.8037
Perturb_14140_KO_Chsy3_SRP250178	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.29787
TCF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3753
Proteinuria	CTD Gene-Disease Associations	1.0	1.68527
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23982
ZNF708_01_130	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.02906
BRD-K39987650_BISACODYL_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30823
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01988
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DoTc2-4510	GDSC Cell Line Gene Expression Profiles	1.0	1.45652
Headfoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937687
BRD-K83270526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23413
Sarcoma_SARC_TCGA-DX-A1KZ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.23074
BRD-K49328571_dasatinib_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584357
CRCGN014_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13764
COL6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87102
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62S-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13878_OE_ABCC1_SRP301382	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.1477
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PUS10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524248
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64793
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03555
PLAU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80031
Perturb_14043_KD_H2AZ_SRP073488	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HELZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34404
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05701
inner nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.808968
BRD-K50081142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34325
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-8115-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TRPM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711698
PLEKHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45841
r4 part of pontine raphe cell population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03522
HEPG2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.06406
Bone Diseases	CTD Gene-Disease Associations	1.0	1.10769
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931572
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945075
BRD-K93034159_2-chloro-2-deoxyadenosine_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DNMT3L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048568
r1 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65674
temporal muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07826
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68772
BRD-A30435184_Metergoline_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67011787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62672
GSE226249_5_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.91129
GABRD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00971966
APOE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486359
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.82729
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23817660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01925
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior cingulate area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21335
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.6491
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.884036
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35329
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22612
Atrophy	CTD Gene-Disease Associations	1.0	1.42129
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
NME7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485107
TLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460454
NUAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065888
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871995
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	5.24199
precuneus, right, inferior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.927045
GTEX-WEY5-0726-SM-4LMID	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63194
Immunoglobulin I-set	InterPro Predicted Protein Domain Annotations	1.0	null
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
smoothmuscle_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.856035
BRD-K77490065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32946
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68647
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.63155
Perturb_16495_KD_RBM39_SRP301121	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SPEG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596042
Perturb_14141_KO_Chsy3_SRP250178	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.6728
BRD-A67799922_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEACAM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495383
BRD-K94012289_OSI-027_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111035,GSE111040_8_v_13_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFIA_Deficiency_GDS2775_640_mouse_Postnatal brains (at P16)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE195568_2_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CD207	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049969
BRD-K06935782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23276
Periglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
GSE237812,GSE237813_3_v_2_hmgb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
APOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24906
NB10	GDSC Cell Line Gene Expression Profiles	1.0	1.61744
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6934
GSE203308_9_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.45052
CNNM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88842
GSE217115_3_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13939_KO_USP29_SRP329795	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.66681
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.17
BLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497886
KCND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586957
Perturb_12635_KD_SPANX_SRP236602	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55856
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.764
BRD-K54622858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01133
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	2.32792
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9642
OST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42239
BRD4-25478319-HGPS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26342
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.4065
Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.53481
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35722
BRD-K41324679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57824
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08381
FSCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641141
KCNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532738
GALR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85553
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50507
BRD-K55795421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05334
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20504
Lung squamous cell carcinoma_LUSC_TCGA-63-7022-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADGRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549293
HS739T	CCLE Cell Line Gene Expression Profiles	1.0	1.62356
TNFRSF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28211
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
BRD-K67439147_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963707
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67604
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-TM_KO_vs_WT-Supplementary_Table_S2-2_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_TM_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12867552_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2708-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2807-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95537020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23425
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944307
BRD-K49878220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53514
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17972
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
Interstitial lung disease 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965666
H2AC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600391
Mesenchymal stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.788
GSE193999,GSE194000_1_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ITGB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552976
BRD-K15794956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25341
BRD-K05153001_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.9941
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HOXB3_HOXB3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11636255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44073
Ghost	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
CASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13087
BRD-A39646320_H7270_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_427_KD_FOXM1_SRP371675	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.56644
CTHRC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634762
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24563
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
BRD-K37691127_Hinokitiol_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Anterior cingulate area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39357
BRD-K96431636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18265
BRD-K46652470_Nizatidine_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Retrosplenial area, ventral part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76506
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
IVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30347
SKOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22509
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68425
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53610452_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.59567
CRCGN008_HEPG2_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2483
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	1.0	0.825725
ELF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10673
sublayer 6a of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1716
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE264621_1_v_3_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.49915
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03774
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
t66-lung_female_1w	MoTrPAC Rat Endurance Exercise Training	1.0	2.03788
GTEX-X638-0226-SM-47JZ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00355
Prelimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37322
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89338336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33463
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0726-SM-48FCS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15873
BRD-K26620362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29317
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q734-1426-SM-48TZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28672
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80O-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLPP_KO_GSE40207_396_mouse_Muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-UJHI-0226-SM-4IHJL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861737
KPNA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00764106
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.76847
WDR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715803
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-68-7757-01B-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41434
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28216
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48206
Perturb_8990_KD_PSENEN_SRP329252	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.35109
GTEX-S341-1126-SM-4AD6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48432
GTEX-S4P3-0926-SM-4AD54	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987398
BRD-A18419789_Etoposide_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20797
BRD-K56761719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66257
PKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04834
OUMS27	CCLE Cell Line Gene Expression Profiles	1.0	2.47236
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25388
BRD-A19500257_geldanamycin_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52101275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44074
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7177-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21772
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Anterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40479
MKN28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52145
GTEX-PWCY-1326-SM-48TCU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09237
PLXDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608702
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849175
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59666
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KASUMI1	DepMap CRISPR Gene Dependency	1.0	3.28685
Myofibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.031
BRD-K37619154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11161
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-DX-A7EF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40562
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35267
BRD-K14211116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15686
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.808501
COQ7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96846
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46065
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12184916_NVP-BEZ235_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87126326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41949
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77888
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08004
BRD-A75409952_wortmannin_T3M10_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE70935_2_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.17938
ZNF844	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56213
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
DGKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531884
PMC10247733-41408_2023_863_MOESM2_ESM.pdf-213-IRF8_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17529
HSPG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605975
TRPM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584847
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.06442
BRD-A24021119_NCGC00183696-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5507_KO_Nir_SRP114858	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
KIF18B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11651
BRD-K69932463_AZD-8055_MDAMB231_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69600043_Thiethylperazine malate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SP-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06301
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50207
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.970374
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5247-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior cingulate area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01733
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
PPARA_KO_GDS2886_484_mouse_small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20476
TEX101	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630181
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12661646-dmm-18-052290-TableS8.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6914-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01107
METTL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18039
BRD-K67399222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76889
BRD-K02708799_GSK-1059615_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22372
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06846
Fields of Forel	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07331
TPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62728
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5489
NRL_Deficiency_GDS2936_631_mouse_Retinas - 2 months	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Mesothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.51
SP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.989079
PMC6964830__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Supratrigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04053
ATN-1	GDSC Cell Line Gene Expression Profiles	1.0	1.62666
BRD-K46703028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21947
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FLO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
VPS52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0079
BRD-K21672174_Ro 28-1675 ?_A375_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739562
Perturb_11949_KD_NRF2_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.0893
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01598
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.964531
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
liminal part of alar r1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38248
BRD-K41859756_-666_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47349976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12689
TUBG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575506
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.312799
NSD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489541
Immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
PMC10319848-mmc1.pdf-3-FOXS1_FOXS1	Rummagene Transcription Factor Associations 2026	1.0	null
ZDHHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5661
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.13583
BRD-K90864987_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03967
BRD-K13637593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01503
alar part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38824
BRD-K29276696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04865
DNAAF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93347
ADCY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560189
GTEX-PLZ4-2726-SM-3P61A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50581
Perturb_4671_KO_Chaf1a_SRP194975	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.5555
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911713
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.50111
Vision Disorders	CTD Gene-Disease Associations	1.0	1.35676
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08242
ZFP36_Deficiency_GDS2456_707_mouse_Fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12661646-dmm-18-052290-TableS6.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ATF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16754
ZFP57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90916
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26786
BRD-K26756394_VE821_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gallbladder	HPA Tissue Gene Expression Profiles	1.0	0.928931
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858344
FES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86586
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04155
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0635
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2337
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A19037878_trichostatin A_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8547-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RMUGS	DepMap CRISPR Gene Dependency	1.0	6.41278
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79090631_CGP-60474_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36418
Confusion	CTD Gene-Disease Associations	1.0	1.14268
BRD-K32787834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03057
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23573
17456722-TableS1	GeneSigDB Published Gene Signatures	1.0	null
breast epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116175
BRD-K56188606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86436
SMKR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00921768
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25391
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4769
BRD-K99944747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13813
Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF787	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24547
GSE254770_3_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55239
Alexander Disease_CNS - Brain - Olfactory Bulb (MMHCC)_GSE977	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.70459
BRD-K96547094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5866
HDAC6_KO_GDS4375_372_mouse_CD4+CD25+ T-regulatory cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210476_9_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77520720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10517
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12634671-41698_2025_1138_MOESM1_ESM.pdf-10-BCL11B_BCL11B	Rummagene Transcription Factor Associations 2026	1.0	null
IL15RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762507
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885769
SIGLEC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621703
GSE210101,GSE210114_1_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.2997
BRD-K87909389_F3055_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
PLXNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55735
RNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7738
Perturb_6216_KO_Mef2c_SRP227204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.2064
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1777
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15739
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF2E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58853
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.09471
BRD-K45522895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26949
adrenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095142
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RTCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01286
Curli	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
k562	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848427
primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.184218
BRD-K16929626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34962
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.838613
NEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98339
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05629
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-3B-A9HO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5263
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04677
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42455570_NCGC00182380-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871995
FPGS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451396
Perturb_15872_KO_SMARCA4_SRP293781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.11548
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QXCU-0126-SM-2TC5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31138
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57027644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04881
PMC7806814-41598_2020_80145_MOESM3_ESM.xlsx-CombinedResults_TreatbySexMainE-Supplementary_Table_S2_Genes_with_significant_FDR_0_05_sex_by_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Adipocyte	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31829
BRD-K79937734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88028
endometrium_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.28383
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.82785
MYOG	ENCODE Transcription Factor Targets	1.0	null
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K99582188_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
19843711-TableS1	GeneSigDB Published Gene Signatures	1.0	null
mammary epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12733
TYMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554831
NCI-H1770	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.992
HS616T	CCLE Cell Line Gene Expression Profiles	1.0	1.78643
cell adhesion	GO Biological Process Annotations 2015	1.0	null
SNU182	CCLE Cell Line Gene Expression Profiles	1.0	1.4421
GTEX-UPIC-1526-SM-4IHLU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24284
CYYR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18977
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35809
BRD-A19500257_geldanamycin_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FFAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0035919
GSE184892_4_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPL-2426-SM-48TDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01541
ADORA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702697
USP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00348855
BRD-A90451247_KU-60019_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACKR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048059
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K15616905_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96647
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48788
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16431_KD_E2f4_SRP327850	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.78903
BRD-K50234570_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052792
BRD-K05000526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29055
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01234
spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.558457
CA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0101404
BRD-A94420133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44294
liminal part of r2 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15903
PMC6070530-41398_2018_200_MOESM3_ESM.xlsx-regional_cluster_PFC-MSC-age-bin_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Jaundice	CTD Gene-Disease Associations	1.0	1.15122
BRD-K77173942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20282
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29242326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42231
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.07152
BRD-K50710005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04904
Perturb_688_KD_ASAP2_SRP406127	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06047
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44533
MOLP2	CCLE Cell Line Gene Expression Profiles	1.0	1.89907
HDAC6_KO_GDS4375_532_mouse_Foxp3(+) Tregs	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1703	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73438
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.5408
ATP1B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677041
DNAJB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62685
PMC6607389__F3	PFOCR Pathway Figure Associations 2024	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56351
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857962
M6PR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28552
19038878-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
DCUN1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71794
LC1SQSF	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46396
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU1J-1026-SM-46MUR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24958
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.830738
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36226
GRB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00952787
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08312
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67815
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CD2AP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549186
SFMBT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627789
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB1	CCLE Cell Line Gene Expression Profiles	1.0	3.40751
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67665
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59112
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22163
PRMT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66408
CCDC86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057105
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3948
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990994
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FAM83F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53553
16397240-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
Perturb_5873_KO_Xpo4_SRP358780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965009
GTEX-W5X1-0008-SM-4LMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23216
BRD-K00028814_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAKI1	BioGPS Cell Line Gene Expression Profiles	1.0	1.59274
Hypertrophy	CTD Gene-Disease Associations	1.0	1.56288
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.859677
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAL1_01_217	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.58653
BRD-K56536691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17529
DUSP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08819
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
Demyelinating Diseases	CTD Gene-Disease Associations	1.0	1.36706
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SK-N-DZ	GDSC Cell Line Gene Expression Profiles	1.0	1.61422
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MPP-89	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5753
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89064
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DUSP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00354671
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K60918542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16245
ZFPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51232
PDSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639856
Perturb_1300_KO_Foxp1_SRP158103	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.80969
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0185
BRD-K82135108_elesclomol_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H2172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PNCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68804
salivary gland	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
GSE151090_2_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88965
BRD-K20526256_HG-14-10-04_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70981
EDEM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668576
RO60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66146
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17739
TAS1R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691456
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
Microfibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.86
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SH3BGRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32959
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961759
posterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32957
RAB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89972
GTEX-SSA3-0226-SM-32QPN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47543
KMT2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069961
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96322
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_chimp_DRSG_lowerRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
INKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84452
CPEB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67631
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929779
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98542
BRD-K56431031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06869
Perturb_5882_KD_EZH2_SRP106792	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60185
IRS3P_KO_GDS1219_305_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08438
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55092
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986917
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15175
RASGRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614748
HCC1500	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46312
OLR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768969
SMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1784
BXPC3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97438
EVI2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611252
Superior colliculus, motor related, deep white layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10331
BRD-K59130783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09709
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3417
RYBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87555
ZNF827	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75965
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.85091
S100A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662763
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33868
BRD-K36354764_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21129
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14586
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Micrognathism	CTD Gene-Disease Associations	1.0	1.33405
GTEX-XUW1-0126-SM-4BOOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49946
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38116
ARFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94123
CDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48134
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0326-SM-4B66K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905185
G11629QQ	GlyGen Glycosylated Proteins	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02886
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.977728
mantle zone of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15831
BRD-A96308662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3513
PNPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94019
Lung squamous cell carcinoma_LUSC_TCGA-18-3409-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GNLY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682922
BRD-K78477132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45482
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55648
TH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00815117
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3726
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	15.3998
Perturb_13571_KD_Islr_SRP160431	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC12661646-dmm-18-052290-TableS5.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16739
BRD-K55940699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06319
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KMRC1	DepMap CRISPR Gene Dependency	1.0	3.36814
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51518
abnormal osteoid morphology	MGI Mouse Phenotype Associations 2023	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88041
CFL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666884
C11orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12955
RIPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00372534
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13905
BRD-K91120514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19813
precentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832964
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A66927094_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920424
Pericyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.737
GSTA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004747
SLC12A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722586
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052702
Perturb_15232_OE_Zscan4f_SRP229595	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05672
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62327
Orbital area, ventrolateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12482
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OIP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627075
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874617
PMC12254341-41467_2025_60760_MOESM3_ESM.xlsx-MR_of_flat_vs_pillar_D_ipp-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LASV_FML29_8hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.99744
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hematopoietic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
GTEX-XV7Q-1526-SM-4BRWB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07904
BRD-K81266242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01324
B4GALNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540333
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.661
COMMD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52471
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71468,GSE76476_2_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3398_KO_Tcf7_SRP077563	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.97659
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.34489
COX4I1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545937
Perturb_12136_KO_Dlx2_SRP339959	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.2216
Perturb_2952_KD_Celf1_SRP003495	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
DPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40446
HOXC9	ChEA Transcription Factor Targets	1.0	null
Perturb_813_OE_TRIB3_SRP262247	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.84126
OSC20	DepMap CRISPR Gene Dependency	1.0	3.05484
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050915
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65255
CAPAN-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
SLC26A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050226
uterus	GTEx Tissue Gene Expression Profiles	1.0	1.06551
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Turner Syndrome_CNS - Brain (MMHCC)_GSE1606	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.70903
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935637
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23296
CHD1	ENCODE Transcription Factor Targets	1.0	null
TUBB2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619982
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35915
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4483
KCTD16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642956
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21816
KCNQ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457502
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A56020723_CA-074-Me_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TE6	DepMap CRISPR Gene Dependency	1.0	2.32831
SDC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640576
LN18	BioGPS Cell Line Gene Expression Profiles	1.0	1.3561
PPARA_Deficiency_GDS2934_632_mouse_Small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZNF543	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43003
Perturb_8477_KO_FMR1_SRP154204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K36271521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0956
PIP4K2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548158
RBPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73445
CTNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72746
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69389
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904623
ZNF880	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38289
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10633
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52500055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21697
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-1126-SM-4DM6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10385
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45372
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CMK115	DepMap CRISPR Gene Dependency	1.0	2.87843
PDLIM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645853
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82935
BRD-K51363316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41914
TMIGD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619514
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.922983
FNDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88077
NSF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396607
GTEX-P4PP-1726-SM-2S1NS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897217
GSE237040_6_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60527
BRD-K39639513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66476
BRD-K66538826_amuvatinib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93881
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100547_HIP_no dementia_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54538
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NAIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3737
Lassa Fever Virus_4hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.15634
MDAMB157	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8781
BRD-K72161580_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53959
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84152
BRD-K06593056_-666_A375_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92018859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02305
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6932
BRD-A11154023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18158
Lung adenocarcinoma_LUAD_TCGA-44-6777-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.939121
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235682_1_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.866993
Perturb_1324_KD_RBM39_SRP301121	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7673
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.873538
BRD-K23585987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21209
layer 6 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11216
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-2.06114
BRD-K49328571_dasatinib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sleep Initiation and Maintenance Disorders	CTD Gene-Disease Associations	1.0	1.02522
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17824
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
photoreceptor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.425726
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
platelet alpha granule	GO Cellular Component Annotations 2025	1.0	null
SPECC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5405
Perturb_13577_OE_Msx1_SRP261181	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
AGXT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589789
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.663
WDFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65677
U2AF1L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06644
Sarcoma_SARC_TCGA-DX-A1KW-01A-22R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138815,GSE138817_3_v_1_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3611	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
hsa-miR-4510	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PSMB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590274
PMC6964830__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GRK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608584
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10725
NKRF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00860339
OAW28	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07586
Perturb_6428_KD_ADAR1_SRP009659	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K85402309_dovitinib_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Secondary motor area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53661
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34467
gata4_21746915_heart_lof_mouse_gpl6246_gds3931	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.558295
PRPS1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066594
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
FOXP2_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IL17C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712493
SGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665837
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K46739745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13015
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67878
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13462_KD_LncMyod_SRP192468	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38115
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45200389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1024
BRD-K06842972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03444
ALDOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53639
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1803
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLEKHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52133
MPST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16066
lateral wings of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59567
C10	DepMap CRISPR Gene Dependency	1.0	4.15746
Enteroendocrine cell_Small intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1463
BRD-K61829047_7b-cis_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7871_KD_PCF11_SRP258098	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.35938
intermediate stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06597
Fastigial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00833
HS934T	CCLE Cell Line Gene Expression Profiles	1.0	1.35403
JHOS2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72371
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
t66-lung_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.09867
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.26638
hsa-miR-3663-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN016_MCF10A.TP53.M_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00459
BRD-K26241953_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64606589_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G43417UB	GlyGen Glycosylated Proteins	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66851
KYSE-410	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6944_KO_Xirp2_SRP259323	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.699
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.75842
LB1047-RCC	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47378
MICAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76119
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45143
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81954
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832451
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.2895
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.991315
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
Lung squamous cell carcinoma_LUSC_TCGA-39-5030-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00942162
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01559
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K23363278_CYT997_PL21_6.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23808
KARPAS-231	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64948
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF879	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26692
PMC6070530-41398_2018_200_MOESM3_ESM.xlsx-regional_cluster_PFC-MSC-age-bin_5_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
cervix uteri	GTEx Tissue Gene Expression Profiles	1.0	0.864773
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5798892-41421_2017_3_MOESM8_ESM.xlsx-down-regulated-Supplementary_Table_S3_Up-_and_downregulated_genes_in_ATF6-_-_hMSCs_compared_to_ATF6_hMSCs_late_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GMPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46566
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
BRD-A24021119_NCGC00183696-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23642
BRD-K97223487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64498
NXT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45207
hsa-miR-1202	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K28916077_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
METTL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44323
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22196
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
rostral group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.979763
GTEX-RVPV-0226-SM-2TF6W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865518
Hip circumference adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
BRD-K89141455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27599
Perturb_15338_KO_Ldha_SRP255398	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.28349
GDF15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576754
SIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56181
PDE10A_KO_GSE40377_581_mouse_Striatum and hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_4595_KD_Trp53_SRP372551	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
G82830MN	GlyGen Glycosylated Proteins	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92089
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
pc3	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
Perturb_13613_KD_Puf60_SRP342713	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.34641
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79516
Lung squamous cell carcinoma_LUSC_TCGA-56-A4ZJ-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MC1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19267
Blood Protein Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1574
SIPA1L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618281
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3646
BRD-A43331270_niguldipine hydrochloride_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-1426-SM-4AD66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993721
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53366
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.857
BRD-K63770300_NCGC00188740-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64222382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45331
C8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00778567
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.962818
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04086
BRD-K51290057_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VCAP	DepMap CRISPR Gene Dependency	1.0	3.20309
XKR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99473
GSE221004_1_v_0_prdm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38975326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18136
BRD-K15433418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23889
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.057
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7859793__F5	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K97224540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00617
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24848743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.142
Kidney Chromophobe_KICH_TCGA-KO-8405-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88510285_B675700.cdx_T3M10_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21042
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dizziness	CTD Gene-Disease Associations	1.0	1.04721
ALEXANDERCELLS	CCLE Cell Line Gene CNV Profiles	1.0	1.39847
KLHL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494412
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04411
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50961
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54695
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
BRD-K37356599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56008
GSE88819_11_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92180676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02236
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1957
CYBRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58902
PANC-02-03	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K67868012_PI-103_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70518736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07103
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLCNKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00424318
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53369
SH2D2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00873813
CYB5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66717
L1236	CCLE Cell Line Gene Expression Profiles	1.0	2.15896
Perturb_15301_KO_Tet1/Tet2/Tet3_SRP318893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
increased osteoblast cell number	MGI Mouse Phenotype Associations 2023	1.0	null
PMC8481886-Table_1.xlsx-A_subsets-fetal_MSC_UC_MSC_bone_marrow_MSC_adipose_tissue_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91057865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00971
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A85860691_chaetocin_MDST8_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34349
K562	BioGPS Cell Line Gene Expression Profiles	1.0	2.137
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26123
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3137_KO_Celf1_SRP082172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.32969
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A81866333_CGS 21680 hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00854177
GTEX-OXRN-0226-SM-2I5EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943131
EED	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41254
JUND	ENCODE Transcription Factor Targets	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K53816426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26744
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15806
PYGM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00987591
FSHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567576
HTR5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583329
RBBP5	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054642
VARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70785
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59863
SRGN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658825
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CIP2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0088941
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12169
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05726
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06675
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08335
ATP5PF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46193
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21741
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R9-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cystic Fibrosis_Pancreas_GSE769	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.05449
CASTOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01382
KP4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35733
Platelet activation, signaling and aggregation	Reactome Pathways 2024	1.0	null
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15414
DHCR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444884
GSE138097_0_v_2_otx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
ESR1	ChEA Transcription Factor Targets	1.0	null
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
S1PR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60934
BRD-K30288714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21484
SIN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00953991
hsa-miR-339-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8145-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17539
Perturb_13524_KD_Brd9_SRP333303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FCRL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533272
BRD-K99252563_QL-XII-47_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN012_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84948
BRD-A87137733_GSK-690693_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61231
GTEX-QCQG-1226-SM-48U23	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922762
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.58889
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63759
BRD-K11853856_PJ 34 hydrochloride_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MRPL40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19884
hsa-let-7b	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GSE169571_3_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cls1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
RMUGS	CCLE Cell Line Gene CNV Profiles	1.0	2.14108
BRD-K36627718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54697
KCNC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529215
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37583
BRD-K90625171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61029
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
NKX2-5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107632
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11325
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EMILIN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.91
ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.899898
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83333
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35857
hsa-miR-3943	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
DCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65705
CCL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675212
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33414
BRD-K42987166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58772
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
ATF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483664
COPD - Chronic obstructive pulmonary disease_Lung Tissue_GSE1650	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.5811
BRD-K33551950_R2146_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GLYCTK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710868
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12160862-ijbsv21p3573s2.xlsx-Table_S12-Supplementary_Table_S12_Differentially_Expressed_Genes_in_fibroblast_grouped_by_SOX11_expression_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30707190_PNU 74654_WSUDLCL2_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adenocarcinoma in situ	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
RASSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27309
BRD-K64606589_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93697231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35687
intermediate stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32059
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
BBS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00912861
Perturb_14763_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K13662825_dinaciclib_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K54332342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28331
NOX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582729
ANKRD33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99739
BRD-K03816923_Rottlerin_HT29_24.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.43957
Pancreatic adenocarcinoma_PAAD_TCGA-RB-A7B8-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452278
creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.029541
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13963
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25198
BRD-K70941721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44596
BRD-K74688087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77677
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5328
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.72322
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11907
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNNC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108937
LMNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25907
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6305
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00822
PMC6870463-Table_7.xlsx-Family_H_LPS-LPS_treatment_of_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.892
Secretory granule lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Tenascin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
PLPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46097
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71265
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68772
Mural cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-VUSG-2226-SM-4KKZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01904
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05707
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.252
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-U25771771_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NME4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681611
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.989823
Lung adenocarcinoma_LUAD_TCGA-50-5055-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TU-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11089039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28933
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07486
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.62741
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65955264_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
retina	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCIH650	DepMap CRISPR Gene Dependency	1.0	2.98897
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11023
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07693
Spinal Cord Diseases	CTD Gene-Disease Associations	1.0	1.24056
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.922021
KIF21B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00435632
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870309
COX6B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00726538
CUBN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00660848
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.924147
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25615
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44916315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68053
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	2.07552
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085414
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1599	GDSC Cell Line Gene Expression Profiles	1.0	1.49875
layer 6 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31717
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.95537
OXSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83604
MAST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626151
SHARPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50295
BRD-K58846294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73355
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_7_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
OXER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620309
organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K22668106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31617
hsa-miR-1224-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
p4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
BRD-K24343201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52133
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.214
PCCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492185
MDAMB361	DepMap CRISPR Gene Dependency	1.0	3.75155
TMEM107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78639
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03736
BRD-K15940471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3823
Perturb_6447_OE|KD_EGFR|TRIM24_SRP100743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1304
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.907506
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HNF1A_OE_GDS1499_252_human_HEK293 embryonic kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11879
15845616-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4823
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23889
u2197	HPA Cell Line Gene Expression Profiles	1.0	1.13593
ANP32E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674921
SPDYE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32
SEMA7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641541
Cystitis	CTD Gene-Disease Associations	1.0	1.09646
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PML	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713718
BRD-K61522760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18123
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBX2_KO_GDS4445_353_mouse_E11.5 XX embryonic gonads	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Stroke	CTD Gene-Disease Associations	1.0	1.15899
KDM7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34307
u937	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
abnormal osteoblast morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-U43867373_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Intracellular signaling and cell migration supercomplex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
MSMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060392
Perturb_5663_KD_HOXD13_SRP256218	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.2118
Perturb_12030_KD_ADORA1_SRP215261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74952
LMAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8547
FOXA1-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.964204
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97424
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17587
BRD-K76174882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28658
H3K36me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE129465_3_v_2_phf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49566
HN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Primary somatosensory area, lower limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19302
periventricular stratum of m1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18329
GTEx Muscle 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	9.83671
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Heart Failure	CTD Gene-Disease Associations	1.0	1.10665
PTPRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660976
BRD-K35389996_2-(4-(pyrrolidin-1-yl)-6-(p-tolylamino)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-04_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KCNK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055705
spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.173104
PNPLA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669541
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39215
Perturb_13847_KO_Mov10_SRP091426	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.33332
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.36117
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21982
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68094
BRD-K97764662_P2499_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7535
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58901
Perturb_5506_KO_Nir_SRP114858	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832717
BRD-K64992851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20602
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842589
BRD-A80213327_NSC 23766_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE252857_1_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.013
RH18	CCLE Cell Line Gene Expression Profiles	1.0	1.53489
TNFRSF13C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607284
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25895
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04565
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9166
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07721
DLX5_Deficiency_GDS4443_356_mouse_E10.5 embryos otic vesicle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K82135108_elesclomol_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.215653
BRD-K91277001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2443
NTMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83647
Lateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37073
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847425
BRD-K74676765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29931
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypospadias	CTD Gene-Disease Associations	1.0	1.20946
PTEN_01_301	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59188
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
BRD-K50287215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02161
SAP30	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18614
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02147
NRK-49F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981873
TIA1_KO_GSE54418_263_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
WT1-20215353-NEPHRON PROGENITOR-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977633
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40559
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02498
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
THNSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665385
HH	CCLE Cell Line Gene CNV Profiles	-1.0	-2.32243
Mesothelioma_MESO_TCGA-MQ-A4KX-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GJB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545229
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05139
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-98	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DGKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0668
UQCR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6181
PRXL2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106875
BRD-K55187425_ON-01910_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pruritus	CTD Gene-Disease Associations	1.0	1.13895
GTEX-PX3G-2526-SM-48TZV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14245
ARHGAP21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57361
RRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98689
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979059
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.729
TPM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736172
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF91_01_123	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.99226
GTEX-X88G-0226-SM-4GIE4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866837
BRD-K93268593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41216
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hek293	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GSE160293_2_v_4_celf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_3_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47758
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532053
CRCGN017_MCF10A.WT.HP_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36085
Heart Diseases	CTD Gene-Disease Associations	1.0	1.12872
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.950988
BRD-K20526256_HG-14-10-04_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-A4JQ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBQLN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56421
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877311
GTEX-S7SE-0526-SM-2XCD8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860076
H3K9me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03308
VSIG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510363
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNCA_KO_GDS4153_443_mouse_Striatum - 6 months	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6463957__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8068
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998123
PPFIA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565753
GSE137144_3_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
18535662-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0211
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lateral dorsal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
NOTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668053
Anterior cingulate area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74344
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2112
BRD-K32176914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32288
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WSU-DLCL2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.56755
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14716
JMJD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567932
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.795714
Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143316_0_v_5_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AKIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7062
hsa-let-7a	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
KMS26	DepMap CRISPR Gene Dependency	1.0	2.94095
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1000-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1464
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9473
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34258763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4627
GTEX-T6MN-0226-SM-32PMD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848061
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19655
posterior intralaminar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76506
ROBO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058162
BRD-K63987422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32157
BRD-K35209334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04776
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66821
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.072128
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27251
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81927
CCDC85B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554129
endometrium_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.4153
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6087_KD_XRN2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.87429
SMAD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0132105
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4889
MAFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74579
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27859
BRD-K40219231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88165
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.987814
ZNF273	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71292
PDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00675
TMEM18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17187
H19_DEPLETION_GDS4787_92_mouse_C2C12 myoblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
WT1	ChEA Transcription Factor Targets	1.0	null
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10418
CREB3L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059155
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRS1_KO_GDS1219_303_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.23362
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93447
LCP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535847
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054076
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02481
GSE210101,GSE210114_11_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE235682_3_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28305
basointermediate isthmic reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06538
BRD-K68548958_-666_NCIH596_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
Perturb_13429_KO_Usp28_SRP044274	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.67297
CLIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06341
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21741
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94713
TM6SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09518
NCI-H446	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.92354
PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MO-1426-SM-4DM73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77914
WASHC2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32712
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
vascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
POU2F2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673889
REST	ENCODE Transcription Factor Targets	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73822
BRD-K55144248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0465
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055383
BRD-K43922968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89847
postcentral gyrus, right, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.933225
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842169
BRD-K75909618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30157
MARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10855
BRD-K09436313_P5172_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ABCC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00929262
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6103
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
BRD-A41250203_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PBXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02043
Perturb_8874_OE_TCF21_SRP081577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
OXTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25502
TTI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00778858
HP1BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33954
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17146
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07111
CEBPB	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LAMP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656095
PAPOLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59217
YH-13	GDSC Cell Line Gene Expression Profiles	1.0	1.64917
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44965
BRD-A38030642_cyclosporine_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49093
RERFLCAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49785
BRD-K01774461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0322
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YE-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKNFI	CCLE Cell Line Gene CNV Profiles	1.0	1.45444
BRD-K13725475_RHODOMYRTOXIN_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD69	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00949395
GSE175787_8_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49075727_nintedanib_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ANAPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03596
CRCGN015_HEPG2_48H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06555
Anterior cingulate area, ventral part, 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26237
BRD-K41809155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36851
BLCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8817
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82289
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
TMEM205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98597
WNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53765
BRD-K49865102_PD-0325901_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOSTDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471168
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vitamin e_mus musculus_gpl1261_gse42813	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CLPP_KO_GSE40207_380_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
r6 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09447
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.833949
PARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58461
CILK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.82461
Leucine-rich repeat-containing N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K15259307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09503
ABHD17C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37783
BRD-K08554278_Hoechst  33342 (cell permeable) (BisBenzimide)_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.23743
BRD-K64634304_Retinoic acid_RMUGS_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZPBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670298
PRR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88194
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43273
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5461
GTEX-S4UY-1226-SM-4AD51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23337
FBXL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640104
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832821
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWN1-2526-SM-48TDS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00136
Perturb_13183_OE_Cry2_SRP303502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.58599
ORM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606318
RNFT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471646
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
PBX3	ENCODE Transcription Factor Targets	1.0	null
COLO-824	GDSC Cell Line Gene Expression Profiles	1.0	1.84933
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33045404_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942277
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7459
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0988
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
intermediate stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08502
mantle zone of r1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38419
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911713
SPEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80881
COLO205	CCLE Cell Line Gene CNV Profiles	1.0	1.79854
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12543
Perturb_470_KO_MIR21_SRP256391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0729
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PTGES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550153
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23573
Lung adenocarcinoma_LUAD_TCGA-MP-A4T4-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perineurium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.855
PPID	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00717598
BRD-K22010301_JLK 6_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K18978916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02324
DYNLL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470698
BRD-K51573654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26302
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.93596
VPREB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699386
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98805
PCTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490537
FBXL20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578011
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14349
AKT_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE156907,GSE160237_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CPT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538174
BRD-A77216878_manumycin A_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.54427
CEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00808954
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5597
BRD-K49861754_5466528_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20937
GJB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578476
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
S1PR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560131
BRD-K99530743_NCGC00242340-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FAM86C2P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2546
BRD-K21025364_NVP-TAE226_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HTATSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08915
SETSIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0208
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00450505
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911713
Lung squamous cell carcinoma_LUSC_TCGA-85-8582-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A47513740_calyculin A_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K02630367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34011
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.843
Platelet degranulation	Reactome Pathways 2024	1.0	null
GTEX-S4UY-1326-SM-4AD4X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911344
KCNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529744
Perturb_158_KD_Prmt1_SRP360688	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.06891
ZWINT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046402
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
BRD-K48012250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03666
BRD-K24614157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76746
Perturb_18391_KO_923_SRP286259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.52991
TSC1_Deficiency_GDS4572_346_mouse_Naive CD4  T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-QDT8-2526-SM-48TYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26427
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	68.1332
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7386-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30296925_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16335
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2902
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_VCAP_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC70	DepMap CRISPR Gene Dependency	1.0	2.22549
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
GJD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595287
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03389
BRD-K66884694_NCGC00167398-02_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90382497_GW-843682X_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKCO1	CCLE Cell Line Gene CNV Profiles	1.0	1.39941
BRD-K53489056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05317
Perturb_5805_KO_Foxa2_SRP280272	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.66391
17963910-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11424
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16959
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82254
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.22431
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6604
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.977176
PMC6319725-pone.0204197.s006.xlsx-Table_S2-S2_TABLE_-_Operon_Expression_and_SOM_clustering_data_for_Gene_Set_identified_by_ANOVA_p_0_005_1005_genes_FDR_8_8_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF860	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55332
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A6JB-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92964
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968419
SKIDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02125
BRD-K94862255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17578
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34703146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57045
BRD-A47633927_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81241
Developmental Disabilities	CTD Gene-Disease Associations	1.0	1.05126
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.13047
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49865102_PD-0325901_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18355
GSE110440_2_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
slow postnatal weight gain	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K18163752_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K85123403_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCT15	BioGPS Cell Line Gene Expression Profiles	1.0	0.825725
Perturb_8987_KD_HNRNPM_SRP311345	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57223
platelet alpha granule lumen	GO Cellular Component Annotations 2023	1.0	null
C1GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36855
Coma	CTD Gene-Disease Associations	1.0	1.14989
U20S	BioGPS Cell Line Gene Expression Profiles	1.0	0.882151
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.057922
Perturb_6432_OE_RBFOX1_SRP372391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.60202
DUSP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678604
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29544
BRD-K42828737_sutent_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IC-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5166
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31038
BRD-K72636697_QL-X-138_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r2 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2936
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842933
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00051
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.945838
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.8827
ZNF646	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78416
CA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605604
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32545
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3452
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16595
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17076
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Primary motor area, Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3649
GTEX-W5X1-2626-SM-4LMI8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968489
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A84816049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58164
BRD-K66254772_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BOC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00851461
KIF3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568189
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
BRD-K36354764_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14675
GSU	DepMap CRISPR Gene Dependency	1.0	3.45879
SMG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60408
SUV39H2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442295
TUSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9587
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53INP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739043
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MONO-MAC-6	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51222
Thrombosis	CTD Gene-Disease Associations	1.0	1.09083
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73395020_ARP 101_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28889
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW626	DepMap CRISPR Gene Dependency	1.0	2.15461
MYPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69663
hsa-let-7c	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r1 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54919
NCIH1568	CCLE Cell Line Gene CNV Profiles	1.0	1.4291
SLC12A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707476
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840348
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0303
GSDMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663087
H3K36me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_348_KO_KDM2B_SRP250460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.50148
GSE238018_3_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44103
Lung squamous cell carcinoma_LUSC_TCGA-56-5897-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZSWIM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46811
BRD-K92093830_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5516
BRD-K94012289_OSI-027_BT20_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DFFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00373677
PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961088
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0372
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41601
CD101	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00748112
prednisolone-265	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPR82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060548
BRD-K53458780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51748
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11238
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5528
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5928-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.840508
BRD-K50387473_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P78B-2526-SM-3P5ZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82215
BRD-K17065706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12973
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24515
BRD-K86111620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79052
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44674
AHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507875
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.004
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05609
BRD-A84524947_1-(3,4-bis(benzyloxy)-2,5-difluorophenyl)-2-(methylamino)ethanol KLK-37_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Platelet alpha granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ZNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6389
SLC16A10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551251
BRD-K76628522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03407
BRD-K39965317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63455
GADD45GIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35177
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911859
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FLT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497966
TNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48036
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.77414
NCIH2196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46256
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.958
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TM2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61813
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868846
BRD-K84457681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22349
BRD-K46609723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02455
ITPRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59331
HS940T	CCLE Cell Line Gene Expression Profiles	1.0	1.37917
Lung adenocarcinoma_LUAD_TCGA-50-5045-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS742T	CCLE Cell Line Gene Expression Profiles	1.0	2.5298
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10234
GSE98705_1_v_0_mdm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.883385
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
MAP3K11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94336
NAA16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73448
BRD-K29684372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01017
BRD-K36627727_T3205_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.2153
BRD-K78431006_crizotinib_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RASSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15223
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAPK1IP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81758
HS606T	CCLE Cell Line Gene Expression Profiles	1.0	1.43846
Perturb_16100_KO_Map3k12_SRP157873	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.87646
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32421
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57968
CYP2S1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713991
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KP2	DepMap CRISPR Gene Dependency	1.0	3.79191
lung	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
Perturb_125_KD_Cebpb_SRP041765	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.94989
BRD-K66416915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20344
Lung adenocarcinoma_LUAD_TCGA-44-2665-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71122
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.189442
LXF289	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60551
BCL2L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00428727
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16355
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47065
BRD-A75409952_wortmannin_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PANX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550229
Heschl's gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.998644
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02758
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00910650_NCGC00242335-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hemostasis	Reactome Pathways 2024	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05201
GTEX-T2IS-2226-SM-4DM65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05842
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYP17A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773814
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CORL23	DepMap CRISPR Gene Dependency	1.0	3.95483
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11219
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC47A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081025
GTEX-T2IS-1926-SM-4DM74	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39717
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4524	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K33697018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00529
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A-498 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
BRD-K29415052_NVP-BGT226_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03974
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-YB-A89D-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39390441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98545
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CORO1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00431639
external cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11073
HLE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_DV90_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7435-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4701050__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GGPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559372
BRD-K07259155_NCGC00182362-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58113140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56177
HSP90AA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33833
A1CF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524913
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59208
COLO741	CCLE Cell Line Gene CNV Profiles	1.0	2.02036
SLC19A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4521
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.37103
BRD-K88510285_B675700.cdx_A549_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH716	DepMap CRISPR Gene Dependency	1.0	12.5579
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52876
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29219
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Main olfactory bulb, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80074
Perturb_6228_KO_Mbnl1/Mbnl2_SRP142522	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.75888
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23573
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824988
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.22625
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26912
Fetal Brain Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.0876
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39012
IGSF10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664118
SK-ES-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.40621
TPST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644421
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.23169
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829729
D-392MG	GDSC Cell Line Gene Expression Profiles	1.0	1.61039
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1558
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41498
GSE113817_2_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A06471483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19668
brain_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04343
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85656316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68049
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-Veh_KO_vs_WT-Supplementary_Table_S2-1_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_Vehicle_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
MTIF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28026
KLRC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620535
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50924
S1PR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00800609
GSE160077,GSE160084_3_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63399
HIVEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577838
BRD-K88119862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14796
Perturb_2750_KO_STING1_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931124
BRD-K21433749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41088
19306436-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K25340465_OSI-930_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RGS7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00970743
GTEX-XYKS-1626-SM-4BRUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59368
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89284
S1PR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00877602
PRRC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81937
GSE203308_1_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03582
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Neoplasms	CTD Gene-Disease Associations	1.0	1.06917
BRD-K21806131_tegaserod_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3116	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62847
ADGRF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00791104
Parafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22989
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05726
PMC12661646-dmm-18-052290-TableS9.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4512-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE441T	CCLE Cell Line Gene Expression Profiles	1.0	1.50238
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8916
ZNF614	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23718
HCC38	GDSC Cell Line Gene Expression Profiles	1.0	1.61403
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3086
FAM136A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19352
TMEM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1723
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34311
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGFBP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621559
BRD-K06685815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48886
BLK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620062
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169571_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TRPV3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639203
15845616-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-3202	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-WL46-0526-SM-3LK7W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953746
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukopenia	CTD Gene-Disease Associations	1.0	1.32667
GPATCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23139
COA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86185
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
ADRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490472
E2F6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32315
EPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96055
BATF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724967
HSP90AB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647181
P2RX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053879
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18213
BRD-K36952018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14602
SSTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553495
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.78146
BRD-A79465854_auranofin_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5815-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heschl's gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11915
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Neutropenia	CTD Gene-Disease Associations	1.0	1.27875
GPX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00435699
BRD-K73581966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75101
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944457
GSE135030_3_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.22893
BRD-K79908599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96968
KLLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70632
DCLK1+ progenitor cell_Large intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
H3K9ac_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63349
17823660-TableS2	GeneSigDB Published Gene Signatures	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848427
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05603
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.687
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14246
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985269
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856843
TNFSF11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669624
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8426
Primary motor area, Layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7402
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.24561
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960086
SLC35B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3541
BRD-K42671261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1511
S100PBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06672
Perturb_15339_KO_Nampt_SRP255398	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.01634
M5 melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
BRD-K92569554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37959
OXCT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52027
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38753
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.915882
Edema	CTD Gene-Disease Associations	1.0	1.6662
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3152
SMIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78483
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2711
CLDN19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29956
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.975537
COR-L32	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MPZL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00869126
BRD-K61555339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69263
BRD-K05653692_DL-PDMP_HT115_6.0_h_64.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Secondary motor area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84265
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19601
17660535-TableS7	GeneSigDB Published Gene Signatures	1.0	null
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2089_OE_hTR_SRP179030	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952185
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	1.93081
GSE162688_1_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900382
Schwalie et al.Nature.P1_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GJA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0046545
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33651
PMC5798892-41421_2017_3_MOESM9_ESM.xlsx-CARGs-MSC-Supplementary_Table_4_Gene_list_for_IARGs_and_CARGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04045
PAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69747
Schwalie et al.Nature.G1_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K48488978_YM-201636_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCaRG_OE_GDS2426_711_human_HEK293 kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
STK17B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470089
CORO1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09353
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196699_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFEMP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683464
Fibroblast_Synovium_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hodgkin's lymphoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0699
PHYKPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768996
BRD-K59626557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06872
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4221
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11086
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.19815
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20952
TCEAL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55393
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32217
hsa-miR-601	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SEPTIN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22873
PHF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596792
GSE126402_2_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985774
BRD-K03406345_5-azacytidine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r2 part of nucleus subcoeruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76183
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486716
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49292348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18106
Perturb_13364_KD_Wwtr1_SRP079400	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.9877
HTR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523644
BRD-K87053028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32817
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04009
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20594
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
FPR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00739555
PNMA6F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66796
TPRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42388
RARA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586803
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08187
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.10013
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834174
TTLL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47942
NHLH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00811186
BRD-A32018906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23544
BRD-K73706189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05852
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914462
Sarcoma_SARC_TCGA-DX-A6B8-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49711
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3544
CRYBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615017
CRCGN014_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05677
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO775	CCLE Cell Line Gene CNV Profiles	1.0	1.34764
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6982-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF726	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86165
BRD-K56214240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24164
RAB11FIP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01014
CDK18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657963
NR4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711013
hsa-miR-3678-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-A70461345_NALOXONE HYDROCHLORIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58902
Mood Disorders	CTD Gene-Disease Associations	1.0	1.13075
SLC4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696624
Perturb_13293_KO_Hdac3_SRP361157	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-XV7Q-2526-SM-4BRV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985684
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28875
intermediate stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62133
RCAF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.915
BRD-K53889798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07812
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68772
GSE179880_4_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56127
LRRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538926
Anterior cingulate area, ventral part, 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40958
BRD-K65598536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56713
BRD-K77547920_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36941
PMC4521181-oncsis201520x8.pdf-50-CSRNP1_CSRNP1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral SC part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22624
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.15223
BRD-K50432649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02999
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atherosclerosis_Aorta Smooth Muscle Tissue_GSE420	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.19068
MTOR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630941
fallopiantube_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.16429
Cytolytic granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IC-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9875
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.958
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6517
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9271
ERN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535648
BRD-A41451487_PK-11195_A375_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_MSC_Huang_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BT-483 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
TRMT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37372
BRD-K28040935_NCGC00241732-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922881
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832895
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06473
BRD-K21841771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13796
BRD-K12929741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2619
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08568
NSD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00880401
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.07947
RORB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81535
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.57018
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868013
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843422
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7376-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807975
PMC7591516-41467_2020_18955_MOESM6_ESM.xlsx-Overlap_DEGs_MSC_Diff_GCTB-Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04714488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19973
placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TUFM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614592
AGRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95411
GTEX-WVLH-0226-SM-3MJG6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10918
HAMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513978
8-MG-BA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Gaucher Disease	DisGeNET Gene-Disease Associations	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.20558
GTEX-XUZC-0926-SM-4BOQF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30831
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Craniofacial Abnormalities	CTD Gene-Disease Associations	1.0	1.41586
BRD-K49810818_S-8599_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A47513740_calyculin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85881
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.85836
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18332228-Table2	GeneSigDB Published Gene Signatures	1.0	null
MAPK1IP1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421388
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FUT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596283
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6224-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3175	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hepg2	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.34162
mnng/hos	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
HK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569154
BRD-K66852478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31128
Perturb_13871_KD_CSTF2T_SRP095849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.40547
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
APOD_OE_GDS3913_489_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_8045_KD_ST18_SRP062868	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.26775
BRD-K51600962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30545
Perturb_4740_KD_Rrpd1b_SRP181219	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.75578
Glioma	CTD Gene-Disease Associations	1.0	1.03901
RUBCNL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646802
H2BC12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18198
Perturb_6502_KO_SOCS3_SRP168556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.42837
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054731
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42666
BRD-K16915521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05089
BRD-K94441949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47937
Pontine reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03818
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.1032
BRD-A55484088_BNTX maleate_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24189
Perturb_11962_KO_Tr1_SRP355815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.3429
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-2126-SM-4JBJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0704
19658189-TableS3	GeneSigDB Published Gene Signatures	1.0	null
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950218
PPDPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03801
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49826
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11629
SLC25A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505776
BRD-K83895653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59995
AADAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662587
15326474-Table2c	GeneSigDB Published Gene Signatures	1.0	null
Perturb_5566_KO_Sorbs2_SRP221026	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.64024
496100313_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.24962
15273739-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
cingulate gyrus, parietal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88766
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BMAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6874
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.203
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05601
PMC4686761-ncomms10068-s3.xlsx-S2G-MSC_down_specific-Supplementary_Data_2G_-_expression_of_down-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
RH-18	GDSC Cell Line Gene Expression Profiles	1.0	2.43512
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.999126
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0075614
DGKD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00763232
HS819T	CCLE Cell Line Gene Expression Profiles	1.0	1.76651
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16197
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6464-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28943
WDR37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96508
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19083
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.56927
BRD-K54224946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34255
Perturb_12699_KO_Ezh2_SRP222765	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.14289
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9449
hsa-miR-3907	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367876
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.903551
hsa-miR-4500	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40115
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3881_OE_HLAC_SRP363812	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.0506
IFNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534795
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963707
ZNF322	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42377
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39058
nasopharynx	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
BRD-K24734706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23333
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15714
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14038
oncostatin-M receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.139
P31-FUJ	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59205
CMK115	CCLE Cell Line Gene CNV Profiles	1.0	1.6952
BRD-K19166598_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.886
RASL11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86942
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32370845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50617
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18629
BRD-A43805296_MLS-0391006_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
platelet alpha granule	GO Cellular Component Annotations 2023	1.0	null
BRD-K77324165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00135
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-ARGFX_UP-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_up_to_an_FPKM_of_at_least_2_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
PKN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.007769
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67878
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88511
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4569
DIFI	DepMap CRISPR Gene Dependency	1.0	2.27996
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10312
Perturb_13045_KO_Tmem259_SRP195618	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.23655
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08559
Inflammation	CTD Gene-Disease Associations	1.0	1.37817
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.29083
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10174
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.891
Ureteropelvic junction obstruction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.06515
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02159857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05995
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02311826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45035
GSE248045,GSE248046_6_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral IC periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26307
GTEX-OIZG-0926-SM-3LK5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833456
NCIH727	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93343
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052977
PRC_DEPLETION_GDS3532_96_human_U2OS cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K67868012_PI-103_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC45A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89689
CEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6056
FFAR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627479
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-CA-geneName_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86776
Ataxia	CTD Gene-Disease Associations	1.0	1.25651
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319848-mmc1.pdf-3-PRRX2_PRRX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27215
TMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3159
Perturb_9489_KO|KD_Prdm16|Appbp2_SRP359770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.6794
ZNF316	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23651
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3392
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus incertus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02247
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76725
GTEX-U3ZN-0726-SM-4DXT5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96825
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1988
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.98887
PLSCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32771
HCC95	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8648
TNNI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711571
BRD-K44052748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37934
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4454
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944673
BRD-K72066653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18692
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3046
GTEX-RN64-0526-SM-2TC5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925412
BCL3	ENCODE Transcription Factor Targets	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09105
BRD-K55442031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28413
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24355
RHCE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00436249
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CORL279	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46987
GTEX-XUZC-1126-SM-4BOPZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869266
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45749
OCUM1	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
GPR12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647675
TNKS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554562
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33828
BRD-K12345912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26039
DNAAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586906
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150634_1_v_0_cd28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060465
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02672
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060662
WI38-VA13 subline 2RA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16041
BRD-K40117723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52924
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49925
HS343T	CCLE Cell Line Gene Expression Profiles	1.0	1.97358
BRD-K64800655_PHA-793887_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LAMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00423402
dermal fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.490229
H2BK20ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05355
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19576
Anorexia	CTD Gene-Disease Associations	1.0	1.43103
intermediate stratum of r1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5473
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4350_KO_Jag1_SRP045701	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Pedunculopontine nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03348
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96
TMPRSS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00793197
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.83064
hsa-miR-765	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JK-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP3R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11573
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24171
Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4458	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
POU5F1_01_05	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60898
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.870195
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34089
BRD-K26997899_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K44432556_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ANXA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465328
BAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95795
12631704-table1	GeneSigDB Published Gene Signatures	1.0	null
NDUFB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544222
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86272
GTEX-P4PP-2026-SM-3P61N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.40495
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16319_KD_HNRNPR_SRP144940	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.24357
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12864860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.289
ETV5_01_304	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62287
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940814
BRD-K02708799_GSK-1059615_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515724
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13087_OE_Kdm6a_SRP225522	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.08406
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
r6 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30459
BRD-A19500257_geldanamycin_BT20_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.941034
Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RSF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
MRC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523419
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53903639_480743.cdx_HCT116_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.928645
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533339
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08464
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85245
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25302
BRD-K19009697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88181
GTEX-S341-1026-SM-4AD71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892726
15326482-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K52361779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43191
PLCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066233
icSARA deltaORF6_72Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.46314
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LB-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00531
BRD-K96799727_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56700933_PEITC_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
LIME1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656504
Cerebellar Diseases	CTD Gene-Disease Associations	1.0	1.24781
Lung adenocarcinoma_LUAD_TCGA-50-8459-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03112
ZBTB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15133
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZSWIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32433
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.93835
GTEX-XOT4-0226-SM-4B66Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871625
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34409
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
TSGA10IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00842572
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06473
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89913
Lung squamous cell carcinoma_LUSC_TCGA-77-8008-11A-01R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46179
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13142
ZNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55748
Memory Disorders	CTD Gene-Disease Associations	1.0	1.68295
SNCA_KO_GDS4153_529_mouse_cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.838421
NR0B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00954956
Cysteine-rich flanking region, C-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
CD27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574265
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5847_KD_Zfp30_ERP109794	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990517
Hodgkin lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48641
BRD-K97943226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89586
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4858740-ncomms11473-s2.xls-HAdV-D9_cr1b_Library_1-Hit_name_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32225
primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.859677
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39406901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04811
BRD-K26272845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51237
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.921215
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26518
hsa-miR-4711-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
BRD-K28512751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05352
FEZ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557497
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PADI4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579384
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62374
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04968881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88522
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.91042
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
NEO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00839495
CBX8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.009923
BRD-K74216068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42827
RBM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19595
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.990793
BRD-K90003650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66539
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.958
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02084
GALE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50989
BNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93901
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923655
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7433-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LDOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32933
GSE252857_1_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17785
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919964
TUNAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52221
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.16833
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23011
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MIX23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66186
GTF2H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4971
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13741
SW1463	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33424
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040142
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03902
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0919
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-11A-12R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FXYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647268
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64444
CENPU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00772494
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Headache	CTD Gene-Disease Associations	1.0	1.2279
REL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752608
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10431
FAAH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619067
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL2L11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04321
BRD-K42918627_GSK-2126458_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88224221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06627
LTBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28221
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.942475
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09825
BRD-K76437403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32441
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39971
GPR87	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690075
GBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578901
ZNF805	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01826
BRD-K32636001_MLS-0437446.0001_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12611713-Table2.xlsx-Sheet_1-Training_Database_AND_Validation_Database_NOT_Diabetes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00891785
SLCO1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055179
BRD-K39913135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08202
Lung adenocarcinoma_LUAD_TCGA-38-4627-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38124
BRD-K78659596_MLN2238_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AMPD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00719744
Mesenchymal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.684
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.07068
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.08421
TNFAIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668766
Perturb_355_KD_MAPK3_SRP308190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.22916
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
17234769-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
CEBPB-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76163
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USP51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.585
CTRC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0075466
Mesenchymal stem cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K99470595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1271
HUWE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459869
AURKAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83564
MSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554247
Duane retraction syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86471
Response to elevated platelet cytosolic Ca2+	Reactome Pathways 2024	1.0	null
GSE137144_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50158
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.966211
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Urinary Retention	CTD Gene-Disease Associations	1.0	1.11809
Perturb_2961_KD_Nsd1/Nsd2/Setd2_SRP058766	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848373
BRSK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655572
F10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676994
ALCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.662
CLCN7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525743
NCIH2122	CCLE Cell Line Gene CNV Profiles	1.0	1.57369
17009876-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.62567
BRD-A96007399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06169
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04028
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30381
RDH13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00824801
BRD-K86937728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26052
GSE198165,GSE198166_8_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29647
SP110	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600381
Lymphoma	CTD Gene-Disease Associations	1.0	1.11639
RAVER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00849873
Vomiting	CTD Gene-Disease Associations	1.0	1.21663
BRD-K36237864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18505
Perturb_1736_OE_NHD13_SRP068420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.2136
CLCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72177
BRD-K68202742_trichostatin A_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WL46-0326-SM-3LK6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26272
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
OVCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7464
TAL1	ENCODE Transcription Factor Targets	1.0	null
bardet-biedl syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.30838
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5236-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00455575
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55041
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838116
BRD-K96764878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.113
BRMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06098
GSE158182_3_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_426_KD_FOXM1/MYBL2_SRP239534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.56644
CD47	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069186
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06213
BRD-K99125195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10888
BRD-K81709173_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28023
KCNJ11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24272
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1361
Perturb_16970_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.78803
G11870QZ	GlyGen Glycosylated Proteins	1.0	null
BRD-K48615268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24754
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829195
GTEX-XQ3S-1026-SM-4BOPJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08477
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91048
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Arteriosclerosis	CTD Gene-Disease Associations	1.0	1.06552
C11orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98306
FDPS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00487899
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.89283
BRD-A36275421_MW-ras12_CORL23_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11571
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34645
LPXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00970435
Lung adenocarcinoma_LUAD_TCGA-75-7030-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6193_KO_Eed_SRP133646	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior cingulate area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21403
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22313
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7825
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35146
Perturb_337_KD_MYC_SRP301562	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.09625
ATG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.443
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.921385
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7636
GTEX-T5JW-1526-SM-4DM5E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35489
GSE198165,GSE198166_5_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WDR82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56877
ZNF418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95233
TNFRSF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14957
Perturb_482_KD_IFI16_SRP298943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.76119
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.30087
BRD-K52560704_methylstat_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10413
ONCODG1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.44858
NB12	GDSC Cell Line Gene Expression Profiles	1.0	1.52929
T3M4	BioGPS Cell Line Gene Expression Profiles	1.0	1.11388
WTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.51871
CD4+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.42228
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7357
DDX25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74553
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22223
secretory granule lumen	GO Cellular Component Annotations 2025	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE125T	CCLE Cell Line Gene Expression Profiles	1.0	1.62842
GTEX-Q734-0726-SM-48TZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55408
Vesicle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
KLKB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21075
PPM1M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53034
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SO-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39707
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-0426-SM-4DXSH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04042
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051328
BRD-K11008696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20677
STAT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069909
GTEX-POMQ-1226-SM-3P61F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965936
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.91679
BRD-K42034238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01379
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.85538
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7367-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.36638
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23R-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09989
Perturb_3397_KO_Tcf7_SRP077563	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.89706
STK19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617824
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POU1F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055175
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07412
terminal paraventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12239
KHDC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527533
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1182
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919491
brain	GTEx Tissue Gene Expression Profiles	-1.0	-0.871447
BRD-K79954583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26135
ARHGEF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59209
BRD-K55399138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.07115
SP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00329
BRD-K99252563_QL-XII-47_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13677_KD_DHX9_SRP018815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.5838
SCA1_Knock-in_GDS3544_562_mouse_Cerebellum - 12 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SSA3-0426-SM-32QPI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951139
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34813
Cleft Palate	CTD Gene-Disease Associations	1.0	1.12838
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.984931
BRD-K30989303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2796
Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.64303
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116930,GSE116935_1_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490427
18332228-TableS5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K10058823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8264
BRD-K49865102_PD-0325901_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.87989
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SQSTM1_OE_GDS2653_651_human_IMR-32 neuroblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XUW1-0226-SM-4BOOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37463
MAP3K4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00974931
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9475
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.89169
intermediate stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09575
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TE6	CCLE Cell Line Gene CNV Profiles	1.0	1.70853
bromopride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29391
FGFR1HighNME5- epithelial cell_Esophagus_Human	CellMarker Gene-Cell Type Associations	1.0	null
PDE10A_KO_GDS4542_291_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-R3RS-0626-SM-48FE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837736
postcentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.971665
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTPN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00932117
BRD-K52075040_-666_OV7_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60875
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
19843711-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K69650333_idarubicin hcl_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5854_KD_SETD2_SRP212710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.28889
BRD-K81651477_Parthenolide_VCAP_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.1136
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889065
CNIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9102
Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BCAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00849883
VSIG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560469
KCNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00690822
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
SBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728345
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A42737819_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF254_01_127	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.41911
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04006
GTEX-UJHI-1626-SM-3DB9A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11206
RABL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74282
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09731
MCF7	CCLE Cell Line Gene CNV Profiles	1.0	1.86614
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084311
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7859793__F5	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K60230970_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86027709_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72255851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46938
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29714
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3B-Up_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5319
BRD-K79072801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31717
BRD-K66870022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31915
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52755
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-R53T-0826-SM-48FCP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11718
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859722
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054175
CALB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42463
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6Z0-01A-13R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33044659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50258
NAGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80091
GTEX-UJHI-0326-SM-4IHJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03109
HS834T	CCLE Cell Line Gene Expression Profiles	1.0	1.53483
SNRPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00937113
Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2629	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.89746
ELK4	JASPAR Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6989-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66826
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02364
ITPR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00801965
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_LOVO_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08084
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51469
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878441
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06972
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18534
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.04913
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4298
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885885
IL22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00705308
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
OTT1_KO_GDS4315_146_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Central Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.04647
ZNF165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80365
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OB inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60975
Perturb_13849_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_14762_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SH3BP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603325
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09256
BRD-K37392901_NSC 632839 hydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC35E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12272
BRD-K15607890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69524
vagina	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932232
GTEX-PWCY-1426-SM-48TCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37196
CTXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51411
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892714
BRD-K68548958_-666_SW948_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Multimerin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
CCHCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19446
BRD-K59045095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.29311
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04546108_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54798
GTEX-SIU8-0426-SM-4BRUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03751
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.926894
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.022
ATP5PB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619701
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	1.0	3.93775
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76428
Sarcoma_SARC_TCGA-DX-A3LY-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.831687
BRD-K62460895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40876
KIAA1143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43794
LIMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536764
ABHD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90799
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14375
increased osteoid volume	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K23280067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10396
lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC11214527-mmc5.xlsx-ADNP-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10269761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25985
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21882
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BZ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82219
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.07625
Perturb_6446_OE|KD_EGFR|TRIM24_SRP100743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ZNF398	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13524
Ventral tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69254
Adenoma of small intestine_Intestinal Epithelium_GSE422	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.16436
TIPRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528676
FLVCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8669
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68182
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58793
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.20691
BRD-K99252563_QL-XII-47_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00859099
BRD-K99525048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63538
BRD-K49294207_BIBU 1361 dihydrochloride_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-2467-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CCDC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74537
FAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512241
icSARS CoV_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.73788
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.68673
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87468
BRD-K71879491_tretinoin_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS822T	CCLE Cell Line Gene Expression Profiles	1.0	1.4761
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29433
SW579	CCLE Cell Line Gene Expression Profiles	1.0	1.39
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18307
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35411
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.901338
BRD-K46155894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.80276
PRDM16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18467
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94580036_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TML8-0926-SM-4DXSJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17413
BRD-K92985620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05554
IFI27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054108
GTEX-PX3G-2426-SM-48TZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18447
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MAFB_MAFB	Rummagene Transcription Factor Associations 2026	1.0	null
POU2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720604
SOAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539054
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25722
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03681
BRD-K84693638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34975
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10732
BRD-K66037923_NCGC00182390-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Middle frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
BRD-K26838195_AST1306_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1279
BRD-K68313733_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DNAJC2	ChEA Transcription Factor Targets	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18665
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67576
BRD-K84518331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33297
GSE88819_6_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43237
BRAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25229
GTEX-N7MS-2326-SM-2HMLD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945184
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30363
GTEX-XV7Q-1426-SM-4BRWA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76747
Perturb_6481_KD_SERBP1_ERP118886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.88829
BRD-K86978618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28506
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
AVPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00819962
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2546
HEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31482
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39437
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33835
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PYGB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622397
GTEX-N7MS-0326-SM-4E3K2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0429
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6019-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.935462
CD81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2023
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38124
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.886717
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
14767473-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
CEBPA-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0268
Perturb_16494_KD_RBM39_SRP301121	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_3571_KO_RAB5C_SRP285142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.41943
BRD-K05649647_-666_HT115_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873191
decreased testis weight	MGI Mouse Phenotype Associations 2023	1.0	null
DDX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45373
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1447
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymph node_CT1_Myofibroblast	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
NUDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79989
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.02922
GTEX-REY6-0626-SM-2TF4G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833113
Utricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
BRD-K86086851_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K14364923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45053
IGLON5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44853
GTEX-S95S-0226-SM-4B656	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994657
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847425
JUP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68334
BRD-A79768653_sirolimus_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6474-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19075
Perturb_15860_KD_ETS1_SRP270313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
hsa-miR-764	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10185
GTEX-TSE9-2826-SM-4DXTF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86736
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.931118
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38355
H3K36me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25609
BRD-K46985581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54562
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NOMO1	DepMap CRISPR Gene Dependency	1.0	3.33587
TIA1_KO_GSE54418_266_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE218580_1_v_3_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HSD17B7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780975
ICAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528114
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.38863
UBE2N	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005341
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5141
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IRAK4_defectivemutant_200_GSE6789	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.35917
GSE199078_1_v_0_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Plasma membrane	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-A55594068_VINBLASTINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
emx2_20962046_e10dot5_urogenital_epithelium_lof_mouse_gpl1261_gds3173	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.094314
BRD-K68086276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07212
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919288
BRD-K15714104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01928
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
Glomerular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Exanthema	CTD Gene-Disease Associations	1.0	1.12495
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928897
Rectum cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
PMC13138062-mmc7.xlsx-DUGs_E2F1_targets-DUGs_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.991667
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189305_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNAJC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90933
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.937
BRD-K38477985_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COX7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97754
ABCB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60441
endometrium	HPA Tissue Gene Expression Profiles	1.0	1.27891
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AFF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46554
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052793
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830031
BRD-K85059356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10873
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00567
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10592
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59704
BRD-A38030642_cyclosporine_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-up-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
TC-YIK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67988
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CK-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACHE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480578
CIRBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559282
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18982
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	1.0	2.69038
GSE95771_0_v_4_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_2958_KD_Fbxl2_SRP162815	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.76388
GTEX-WRHU-1126-SM-4E3I1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10576
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9161
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00615600_AG14361_MCF7_24.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FGFR1_activemutant_58_GSE17916	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.49256
18400362-Figure4a	GeneSigDB Published Gene Signatures	1.0	null
Perturb_1068_OE_PHF19_SRP188592	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.8134
Hemorrhage	CTD Gene-Disease Associations	1.0	1.24812
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.70265
BRD-K21672174_Ro 28-1675 ?_SKMEL28_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_15863_KD_KDM3A_SRP270313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.53308
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NCIH1573	DepMap CRISPR Gene Dependency	1.0	3.77252
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.014
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FBXO11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30108
BRD-K14203360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81489
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08768
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAPRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67408
SNW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33929
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD151	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547129
RSPH9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00738489
GSE211744_8_v_4_gdf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF75D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74617
MED12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.3298
NCI-H446	GDSC Cell Line Gene Expression Profiles	1.0	2.33206
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDGFL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00958659
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29136
BRD-K41135617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14661
Perturb_5653_KD_EWSR1_SRP117628	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.7084
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.901
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.999264
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
14749371-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K08233096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40357
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45193
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69048559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25503
intermediate stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30766
hsa-miR-4649-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K35424586_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9734_OE_ADAR_SRP401122	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.42588
DUSP22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79056
PANX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532313
BRD-K38273742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01309
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90969
GTEX-XUYS-0226-SM-47JX1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846992
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.43913
Lung adenocarcinoma_LUAD_TCGA-55-6978-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A45607610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31306
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMBIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532531
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51177
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05571
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27397
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19614
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49778
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55487965_NCGC00182364-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYTH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416763
BRD-K13839731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37909
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5828
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.87051
BRD-A55594068_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MANSC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600716
GSE203308_7_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2BC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59098
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04466
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14246
ECT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3968
BRD-K06543683_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2992-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0433
BRD-K49403449_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_13678_KD_DHX9_SRP018815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.7943
TNPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71068
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943695
FAM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29615
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49005
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929181
ANTXR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00730027
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06739
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.935836
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01978
BRD-K52075040_-666_HCT116_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-DX-A3LW-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17686_OE_HSD17B1_SRP366068	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.53934
AJUBA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733134
periventricular stratum of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26458
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986669
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K23467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25972
HS688AT	CCLE Cell Line Gene Expression Profiles	1.0	2.06822
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833138
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
OB mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6087
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4769
FCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539323
S100A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573008
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40675
GALNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59607
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
EFM19	DepMap CRISPR Gene Dependency	1.0	6.20769
EMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44225
BRD-K53328210_JW55_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.038
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08322
HCC70	GDSC Cell Line Gene Expression Profiles	1.0	2.69586
Squamous epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.36
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UA-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13949_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.83373
Perturb_11945_KO_BATF_SRP096865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.95627
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857056
DAPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006197
SEC14L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00419559
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6778
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00386665
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052046
ELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92723
BRD-K84987553_MDM2 Inhibitor_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BCDIN3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19887
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
KLF15_Deficiency_GDS2687_648_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93741
TNFRSF18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712791
Acute Myeloid Leukemia_LAML_TCGA-AB-2854-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571777
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.33653
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939913
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6265
appendix	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048757
IMPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0107254
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10032
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GLP1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046758
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K95352812_NCGC00188530-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NQO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722014
BRD-K87909389_F3055_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2BC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586207
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15216
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45707
WT1-20215353-NEPHRON-PROGENITOR-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SLC7A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00391896
Perturb_6476_KO_SETD6_SRP341895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
DUSP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31864
LTBR_INHIBITION - 27 Day_GDS2004_736_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CDK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396106
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1158
Olfactory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01736
KCNE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00838975
SLC25A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24839
Perturb_17806_KO_ZNF675_SRP304971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54636
Seizures	CTD Gene-Disease Associations	1.0	1.2975
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
BRD-K34098590_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SARS-BatSRBD_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.6869
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70941
MGAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744003
BRD-K74797618_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.876699
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.5539
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04515
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.396
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10526
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05724
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
BRD-K97247086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39211
H3K36me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96854
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64908
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.833187
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02507
gallbladder_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.31976
HPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530178
Immunoglobulin-like fold	InterPro Predicted Protein Domain Annotations	1.0	null
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29496
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37133
HTR2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578413
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.874363
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.14218
ORAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33011
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8533
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Cirrhosis	CTD Gene-Disease Associations	1.0	1.29533
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6893
hel	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
BRD-K65392908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27678
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K42008693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2094
SMIM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11463
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22607
SLC22A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00398471
BLTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17486
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81436
GTEX-TSE9-2526-SM-4DXUS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995834
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00451
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.868
15793299-TableC	GeneSigDB Published Gene Signatures	1.0	null
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58067
H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IGR39	DepMap CRISPR Gene Dependency	1.0	2.42345
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19152
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839005
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930324
PMC7591516-41467_2020_18955_MOESM6_ESM.xlsx-Overlap_DEGs_MSC_Diff_GCTB-Gene_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKAA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425724
Primary somatosensory area, barrel field, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08694
PDE3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055868
TE8	CCLE Cell Line Gene CNV Profiles	1.0	1.63421
ZC4H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18487
BRD-K55867695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37779
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.22016
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19689
BRD-K49865102_PD-0325901_HT29_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S341-1326-SM-4AD72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37053
GSE184399_0_v_3_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38374
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964374
celecoxib-482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ASIC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699275
SLC29A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00885513
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinoma, Hepatocellular_Hepatic Tissue_GSE2127	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.63842
Coelom	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.463
BRD-K10649245_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ID1_01_117	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.45728
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949975
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51223
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
ventral pallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13292
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-6175-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872016
hsa-let-7i	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
COX7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066037
GNAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20104
Interstitial lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901605
HS839T	CCLE Cell Line Gene Expression Profiles	1.0	1.70858
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14415
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIGLEC7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770993
BRD-K50941200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0967
PCI-4B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-U51024685_HG-6-64-01_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05877
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841688
BRD-K13038935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32266
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.07269
Weight Loss	CTD Gene-Disease Associations	1.0	1.36961
Perturb_9090_KO_SMILR_SRP155025	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.3035
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OV7	DepMap CRISPR Gene Dependency	1.0	2.74716
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6607389__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
GTEX-P4PP-2426-SM-3P61L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02413
SKMEL19	DepMap CRISPR Gene Dependency	1.0	2.86458
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3501
BRD-K67742177_(4-(2,5-di(furan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)(furan-3-yl)methanone KUC106884N_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rectus femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074053
CEP131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20703
Skin Diseases	CTD Gene-Disease Associations	1.0	1.42047
mp5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
SRPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00392949
ADIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44085
BRD-K55218521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.449
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052821
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85579
BRD-K76617868_Fasudil hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47282
BRD-K37254228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10755
EHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90618
BRD-K06876397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11862
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17652
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00865988
BRD-K09511124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57707
GTEX-P78B-1926-SM-3P616	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16302
Perturb_9091_OE_HUR_SRP293260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.85009
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8941
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07204
Perturb_6484_OE_NEUROG2_SRP292702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.67837
m1Lim (VL) part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18472
BRD-K27354087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03265
BRD-K40760168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25273
SELENOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54223
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.905693
GHRHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535387
PEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56951
IFNA17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0127738
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
18308945-Table2	GeneSigDB Published Gene Signatures	1.0	null
U2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657839
BRD-K29366596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13243
BRD-K81644801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13841
TRPC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571636
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14349
PIGH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00952447
DKC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055658
GSE110038,GSE133995_3_v_0_hic1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
BRD-K47983010_BX-795_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3417-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00591
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05462252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17678
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05652
BRD-K86988191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29615
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45928581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33613
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K01436366_XMD-1150_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JMSU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34218
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE195513_2_v_1_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SEPTIN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37088
FANCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61137
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02989
Acute Myeloid Leukemia_LAML_TCGA-AB-2899-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4688	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.61944
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21931
BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PWWP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7444
FGFR2_activemutant_59_GSE17916	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63063
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QV-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847425
GSE210101,GSE210114_11_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ACBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13581
BEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88849
PMC6070530-41398_2018_200_MOESM3_ESM.xlsx-regional_cluster_PFC-MSC-age-bin_6_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2708
SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55078
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21209
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26766324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43195
GTEX-UJHI-1226-SM-4IHLR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13974
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5049-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08992
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13672
abnormal bone marrow cell morphology/development	MGI Mouse Phenotype Associations 2023	1.0	null
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.934795
uterus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.0219
CBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23854
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892629
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
Stromal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
EHMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695958
C5orf34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39426
NEK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467871
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
BRD-K30895360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15857
LYZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467674
VGLL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480023
MNT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679898
G84452RH	GlyGen Glycosylated Proteins	1.0	null
DPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98231
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.933239
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA2_01_61	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.6796
IL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107597
BRD-A62809825_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.984931
Perturb_13873_KD_ELF4_SRP182698	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.69118
ganglion cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.517678
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88687
EPHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47499
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77042
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01491
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4588
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PFSK-1	GDSC Cell Line Gene Expression Profiles	1.0	1.56268
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.854798
Cerebral Hemorrhage	CTD Gene-Disease Associations	1.0	1.22758
ovary_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.99585
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05913
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12481
NFATC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42591
Uterus-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	10.5409
ZNF514	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.969
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.893553
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77382
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
endometrium_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.52529
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14375
HS600T	CCLE Cell Line Gene Expression Profiles	1.0	1.40715
NFE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614236
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.7046
SIK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67083
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8298
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38447
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-1426-SM-3P61D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56899
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	2.32526
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_2_TBRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K70792160_Akt inhibitor X_HEPG2_6.0_h_24.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EXOSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90244
Lung squamous cell carcinoma_LUSC_TCGA-46-3767-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7802
BRD-A39506880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25466
ANKRD44	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00781462
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997421
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06473
PMC12661646-dmm-18-052290-TableS7.xlsx-Table_S7_related_to_Fig5D-Fig_5D_-_overlap_between_genes_differentially_expressed_in_presence_absence_of_FOXP2_with_cerebellar_organoid_data_FOXP2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-0626-SM-4KL1Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891307
BRD-K77547920_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WL46-2026-SM-3LK7U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941218
TMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00904412
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27869
PMC6964830__F8	PFOCR Pathway Figure Associations 2023	1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6552
IRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617712
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68548958_-666_HCC515_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5872-02A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A41692738_S1169_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TIMD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609485
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.870957
Acute Myeloid Leukemia_LAML_TCGA-AB-2821-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUZC-1026-SM-4BOPY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857159
BRD-K68174511_torin-2_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
orbital frontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.833414
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871995
Perturb_572_KO_Plod1_SRP321648	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.9638
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hydrometra	MGI Mouse Phenotype Associations 2023	1.0	null
EPHA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494311
Perturb_13136_KO_Gadd45a/Ing1_SRP149486	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
DCLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554584
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20448
QA-27-XW03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.577309
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
breast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068371
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29947
Fibroblast_Stomach_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04654
CRCGN015_MCF10A.TP53.M_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2876
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07617
Bladder Urothelial Carcinoma_BLCA_TCGA-SY-A9G5-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6483_OE_ASCL1_SRP292702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.2299
CRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00612836
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0351
SLC2A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527505
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11624
CD8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620724
RPSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76554
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08899
WSUDLCL2	CCLE Cell Line Gene CNV Profiles	-1.0	-2.48935
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987104
SCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29522
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.333964
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.917923
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46099
OCUBM	DepMap CRISPR Gene Dependency	1.0	2.91481
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919964
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58682
Epstein-Barr Virus_Akata BL clone-4hr starve_None_GSE19761	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.2174
Leucine-rich repeat	InterPro Predicted Protein Domain Annotations	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
OSCAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00825589
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX17	JASPAR Predicted Transcription Factor Targets	1.0	null
PCSK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651971
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11688
BRIX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00885686
TBPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46002
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ATRAID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28415
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874664
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.898465
D-283MED	GDSC Cell Line Gene Expression Profiles	-1.0	-1.87857
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5935
GTEX-P4PP-2526-SM-3P61P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08431
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37587
Kidney Diseases	CTD Gene-Disease Associations	1.0	2.00815
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.65271
GTEX-XUYS-0426-SM-47JX3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979569
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985953
BRD-K28115298_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39087188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17147
BRD-K54262203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12818
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8988
Red nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10394
Sarcoma_SARC_TCGA-DX-A6BE-01A-41R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_362_KD_RAC1_SRP387923	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5889-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29648
BRD-K37940862_NCGC00185684-02_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14571
POLE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00867051
skin fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.340019
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.1467
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03021
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12116
BRD-K27287379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18853
PMC6667477-41467_2019_11105_MOESM2_ESM.xlsx-Primary_screen-HDR_fold_change_relative_to_control_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50121
TUBB4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773447
GATA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.55676
BRD-K24426149_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLITRK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68817
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06473
BRD-K37790543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54301
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7403
MS4A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591624
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
platelet alpha granule lumen	GO Cellular Component Annotations 2025	1.0	null
BRD-K73579545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84229
sublayer 6a of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11597
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66299486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19343
PMC3470785-NIHMS377161-supplement-3.pdf-421-HOXB1_HOXB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.696
ZC3HAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98708
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.931262
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07786
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1187
BRD-K36164005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13796
MAP4K4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00329945
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MPPED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054052
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990994
NOL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491157
GSE203308_6_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4P3-1326-SM-4AD6V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902873
CEBPB-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73808079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66284
TSPAN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56498
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05037
hsa-miR-1245b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54781
ZNF671	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42833
Liver Diseases	CTD Gene-Disease Associations	1.0	1.78416
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.82779
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956067
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911713
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3799
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36262
KDM3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620541
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75904
CLK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619582
BRD-K52551495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07646
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.39855
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09392
CERT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584514
cellular_component	GO Cellular Component Annotations 2015	1.0	null
CLN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630546
Uterine Carcinosarcoma_UCS_TCGA-N6-A4V9-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87656
Anterior cingulate area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2043
NLN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484535
BRD-K48691513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33822
GPBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74624
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226397_0_v_1_cystine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.707
TTI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3255
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19062
NCIH2170	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76679
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
TEAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17686
GSE210101,GSE210114_1_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27762
ZNF620	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93679
Perturb_14846_KO_Zfp36l3_SRP055206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.8989
SNCA_KO_GDS4153_530_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K68336408_Tyrphostin AG 1478_MCF7_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ILF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592339
BRD-K53291208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26003
long insular gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.925132
ZNF397	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52813
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.4049
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10713
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01709
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4896
Pain	CTD Gene-Disease Associations	1.0	1.34782
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13488816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47827
Lymphatic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77473
PMC7585942-mmc5.xlsx-RBM10_OE_upregulated-Supplementary_Table_S5_RBM10-mediated_gene_expression_changes_in_BEAS-2B_and_PC9_cells_Cutoff_P_0_05_log2FoldChange_1_KD_knockdown_OE_overexpression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24694
PRELID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08686
Posterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32899
SCN1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00780782
Protozoan Infection_Intestinal Epithelium_GSE2077	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.47243
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28796
RPS6KA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.254
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47664
TMC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084917
BRD-K05222558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76073
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82697
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DENND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0771
IDH3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73531
CLDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509745
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977123
TRAF3IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57659
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72602
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06218
UHRF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452739
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37787
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75059
Perturb_4504_KO_Hoxa1_SRP174196	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.9903
LRRC8E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01453
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19363
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29127
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Main olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87023
CYP2B6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739916
GTPBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556414
CRCGN015_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07997
LCP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689933
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KCND3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050037
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FGFBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065811
hsa-let-7d	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
CTCF	ENCODE Transcription Factor Targets	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857317
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUJ4-1926-SM-4BOOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904337
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825656
Sarcoma_SARC_TCGA-DX-A48K-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49865102_PD-0325901_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K66032149_VU0365117-1_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86492010_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44455
Hypb_Deficiency_GDS3641_522_mouse_Yolk sac from E9 embryos	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07582
Perturb_13611_KD_Puf60_SRP342713	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.54536
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24815102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99319
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15583_KO_Ctnnb1_SRP251042	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.11861
Hypertension	CTD Gene-Disease Associations	1.0	1.36104
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66558
BRD-A58767537_afatinib_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06665
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.899898
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1329
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40732
Lung squamous cell carcinoma_LUSC_TCGA-56-8503-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08064
BRD-K61033092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50663
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.966
BRD-K81418486_vorinostat_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00847459
BRD-A79768653_sirolimus_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_5678_KO_Pgr_ERP140354	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962484
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36941
BRD-K12089436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13238
stomach_3b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905405
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19614
RBM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78905
NSD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065588
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930977
BRD-K01367715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32773
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.764
BRD-K92457070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98702
BRD-K42032479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00448
EFE184	DepMap CRISPR Gene Dependency	1.0	3.40914
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980728
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29147
BRD-K49530286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50271
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.41174
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7397-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5WG-1326-SM-4LMI9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27417
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.02896
BRD-K66831269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22552
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.52728
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959834
NCIH446	CCLE Cell Line Gene Expression Profiles	1.0	1.60018
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846014
TK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20544
ZFTRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89925
NEK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534153
SOX10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538718
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.21809
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36964
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22544
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41401
spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
15374961-TableS2	GeneSigDB Published Gene Signatures	1.0	null
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07531
Bacterial Infection_Peripheral blood mononuclear cell_GSE3026	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.90022
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38124
MARCKS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479409
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82435
Perturb_13869_KO_LIN28B_SRP284310	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.39888
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34595
IRF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545505
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05698
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72515
SBDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00787397
BRD-K06792661_Narciclasine_TYKNU_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HTR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587927
RAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00759583
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.911953
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Linear nucleus of the medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41725
BRD-K60623809_SU11652_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.04777
GTEX-X4XX-0008-SM-46MVK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985216
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
Collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.083
MTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524891
ZNF780B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69953
CHSA0011	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TMEM238	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85763
PMC4686057-pone.0145107.s001.xlsx-PAA-CAA-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05556
Perturb_7752_KD_YTHDF2_SRP155278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.58121
ARL5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479716
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82928
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21443
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970551
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.848095
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64932
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
BRD-K52406139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1362
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RSL1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655855
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64978
Hematologic Diseases	CTD Gene-Disease Associations	1.0	1.13963
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960129
hsa-let-7f	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
SLC15A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590287
R3HDM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00901316
Perturb_3580_KD_UBE3A_SRP124518	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26434
ZNF43_01_125	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.08987
PMC2276341__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77953978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50895
BRD-K59744424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10054
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
biological adhesion	GO Biological Process Annotations 2015	1.0	null
SHC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0117714
organelle	GO Cellular Component Annotations 2015	1.0	null
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	2.03731
hsa-miR-3150a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
MEG01	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51662
MMP17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1942
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37834
XPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72455
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953484
BRD-K37283718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41749
Perturb_7731_KD_DIS3_SRP062389	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.27699
ovary	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.20427
BRD-K83289131_CAY10618_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148494,GSE182513_1_v_0_hoxd13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TYMS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00414839
SNU840	DepMap CRISPR Gene Dependency	1.0	9.05007
BRD-K35324337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54018
Perturb_13875_KO_LIN28B_SRP335506	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.2446
GUCY1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553041
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69219
ACVR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62299
ADIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78922
Lung squamous cell carcinoma_LUSC_TCGA-22-5489-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628287
STAT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31086
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
secretory granule lumen	GO Cellular Component Annotations 2023	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14375
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.02184
HINT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80654
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97926
BRD-K39624517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26003
GTEX-UJHI-1326-SM-4IHJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02956
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39058
ELF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00764552
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KBTBD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60327
ovary	HPA Tissue Gene Expression Profiles	1.0	1.33835
Perturb_15051_KO_Runx2_SRP302347	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.51598
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_563_KD_MYCN_SRP158473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.53542
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81709
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.825526
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93279
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1729
MRE11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055251
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62066
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-WEY5-0826-SM-4LMIH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25762
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46987
SLC33A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57832
PHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27313
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67825
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.154484
NCIH2170	DepMap CRISPR Gene Dependency	1.0	2.21206
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919964
TRPM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522717
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27564
CDR2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43382
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
SK-MM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2882-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09149805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41835
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89891
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	1.01469
GTEX-P4PQ-0226-SM-2S1NK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11664
RORA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768148
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6115_OE_Cebpb_SRP132418	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.54443
MGME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18126
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857711
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02059
BRD-K99252563_QL-XII-47_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0071687
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02275
FPR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707226
FCGR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007975
Perturb_16969_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.85068
Perturb_5436_KO_Rspo3_SRP363653	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.5613
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.1658
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1368
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09048
BCL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58
TMEM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60291
BRD-K47951404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64919
MFE-296	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929071
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67987
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
BRD-K67868012_PI-103_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24972
ADO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495019
Perturb_13851_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951497
SMTNL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0118288
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRDX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635818
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.2124
KDM5B	ENCODE Transcription Factor Targets	1.0	null
BRD-K89179622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28239
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24393
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877473
BRD-K47314501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21547
USP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0075794
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1048	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.938292
Motor nucleus of trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05699
ARHGEF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79003
Prostate adenocarcinoma_PRAD_TCGA-HI-7170-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51507
HCC-56	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36438
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
BRD-A19500257_geldanamycin_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23176
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.917
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84645
KRTCAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3673
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31499
DMRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7452
ASH1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493413
periventricular stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22368
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MS4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685907
diethylstilbestrol_mus musculus_gpl81_gds982	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04989
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23922020_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40697889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27753
GPR143	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695208
NR3C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485252
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11597
BRD-A76528577_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56533
Lung adenocarcinoma_LUAD_TCGA-MP-A4TK-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902905
Fibroblast_Skin_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.114
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52669
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K76023734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27979
16168083-Table2	GeneSigDB Published Gene Signatures	1.0	null
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.31073
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5823
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.844804
BRD-K37561857_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bj	HPA Cell Line Gene Expression Profiles	1.0	1.20305
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Bacterial biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
RBBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91647
PRKCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693903
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052931
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33511
Senescence_frontal cortex_GSE1572	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.83918
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900017
MCM3AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32819
BRD-K05041614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47255
U138MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71061
Vascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	3.55
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16331
TMEM145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.764
GTEX-WL46-0426-SM-3TW8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5692
Perturb_7747_KD_CNOT1_SRP155278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.10404
Perturb_15714_KD_Ctcf_SRP173291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.21497
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.978836
GTEX-XYKS-2726-SM-4E3IC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981505
BRD-K09871160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17368
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0466
BRD-K63624341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23597
hsa-miR-4433	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ZNF665_01_129	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.25032
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPAIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53795
DCTD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89637
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01947
UGCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82489
BRD-K39709957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07981
DEXI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21949
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
SBK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36211
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IQ-01A-31R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6144
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
EW-13	GDSC Cell Line Gene Expression Profiles	1.0	1.96137
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08878345_MLS-0075347.0001_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4852
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9579
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869063
TOLEDO	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1571
NCI-H1703	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CACNA1S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00776793
Lung adenocarcinoma_LUAD_TCGA-64-1679-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198254_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5006_KO_BACH1_SRP143680	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.35211
NDUFV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73625
NLGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1096
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NB12	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.90601
long tibia	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K09132007_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PAPSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00767672
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54941
HCT8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51513
GSE211955_1_v_0_jmjd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SULT1C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02975
Perturb_1735_KO_Zbtb33_SRP295422	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.09485
GTEX-O5YW-0426-SM-3MJHJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827806
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57259
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Platelet alpha granule lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACY3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466298
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Stellate cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.942
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16884
LRFN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51812
Nausea	CTD Gene-Disease Associations	1.0	1.32103
CTTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33109
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850969
ABCB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00870759
OC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K84106030_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1_01_171	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61116
TMEM117	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437914
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14767
HCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00379289
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K61829047_7b-cis_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paresthesia	CTD Gene-Disease Associations	1.0	1.02114
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5603
NF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00718024
FPGT-TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00748103
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.85297
15980968-Table3b	GeneSigDB Published Gene Signatures	1.0	null
P-22077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05351
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95526
SHANK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40561
Splenomegaly	CTD Gene-Disease Associations	1.0	1.22727
GTEX-XOTO-0226-SM-4B66H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82783
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1391
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.16799
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89176
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DHFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00419235
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00252
GALNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00844527
HCC-4006 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.581
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37909
Mesenchymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
SNU119	CCLE Cell Line Gene Expression Profiles	-1.0	-1.74763
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18308
BRD-K36198653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08859
CRCGN015_MCF10A_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0109
PDILT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568549
COX7A2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90685
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3108
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24793
Perturb_4012_KD_AHR_SRP262152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
NAMPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0033202
CD79B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90974
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_A375_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
U937	CCLE Cell Line Gene CNV Profiles	1.0	1.56703
BRD-K87180723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12586
Lymphatic system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20722
FUT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484294
SUMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489125
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03261
GSE213988_0_v_1_rrm2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2048
BRD-A25736793_everolimus_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CSGALNACT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00824313
CELSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90182
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45969405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1241
Perturb_14758_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TTC642	DepMap CRISPR Gene Dependency	1.0	3.93643
GINS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051139
DHRS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5505
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parkinson's Disease_Substantia Nigra_GSE7621	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.64434
COL1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47188
PLCL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573829
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2233
DARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561963
MKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03541
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17188
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.27409
GTEX-RWS6-1726-SM-47JXP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71557
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37857
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4291
BRD-K34797601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84083
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.445
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10159
GAMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58247
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62591
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF367	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610766
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0364
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.868497
BRD-K35133923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05838
Perturb_4263_KO_OTX2_SRP388433	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.08541
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983555
GSE156115_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17042_KO_Phf6_SRP153916	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.89694
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Olfactory glomerulus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.932
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72456
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48742
BRD-K67835515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35225
FECH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00912347
Proteasome core complex, alpha-subunit complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.995
GTEX-WRHU-1326-SM-4E3K7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869404
adrenal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.435672
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4EP-0826-SM-3P5YK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884257
BRD-K66876909_linezolid_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22612
CBY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97427
FOXO1-32281255-CHONDROCYTES-HUMAN-OSTEOARTHRITIS	ChEA Transcription Factor Targets 2022	1.0	null
ANXA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403955
Lung squamous cell carcinoma_LUSC_TCGA-77-8008-01A-21R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.83231
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73680186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07771
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43729445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43577
DBF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52203
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-07-IZ32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422809
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Pancytopenia	CTD Gene-Disease Associations	1.0	1.16633
VCAP	CCLE Cell Line Gene CNV Profiles	1.0	1.60086
BRD-K68202742_trichostatin A_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00773404
ALDH1B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515622
Human - Fetal Development - L2 - Thymus-Stromal cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
ZBTB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02947
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4728-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS153	CCLE Cell Line Gene Expression Profiles	-1.0	-3.14012
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13038
S100A16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94671
PMC6279925__F4	PFOCR Pathway Figure Associations 2023	1.0	null
TTBK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642631
BRD-K52075040_-666_A375_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-2226-SM-46MUE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02794
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995237
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14952_OE_Tnfsf14_SRP148550	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Perturb_7652_KD_RRP40_SRP126942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.46926
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32421
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLINT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78567
hsa-let-7g	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
MORCPR	CCLE Cell Line Gene CNV Profiles	1.0	1.85111
BRD-K16189898_CHIR-99021_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.854758
cholecalciferol_mus musculus_gpl6246_gse41184	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
subiculum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.869924
DNLZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587932
Perturb_15772_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
hsa-miR-4493	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.970165
BRD-K16705434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42216
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K29458283_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DAGLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668778
BRD-A35869383_ibrutinib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C99	DepMap CRISPR Gene Dependency	1.0	2.1921
Tripartite ATP-independent periplasmic transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
BRD-A20968261_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984289
BRD-K13662825_dinaciclib_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADORA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745791
Immunoglobulin-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
MMAC-SF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K86574132_-666_A375_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951067
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06288
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE71468,GSE76476_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
IGF1R_knockout_151_GSE32936	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.2298
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.7395
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84553
GSE143316_0_v_6_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PKN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403004
BRD-A42246453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6421
Lung squamous cell carcinoma_LUSC_TCGA-66-2737-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
VIRMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2249
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2748_KO_STING1_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.836219
ovary	GTEx Tissue Gene Expression Profiles	1.0	0.93762
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06317
SIGLEC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639998
HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PORCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00738156
AR	ChEA Transcription Factor Targets	1.0	null
STRBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08574
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35520972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22591
BRD-A27080191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49057
RCAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95717
hsa-miR-1254	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69046
STIMATE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97515
KYSE-450	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CARD11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549392
BRD-K01436366_XMD-1150_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UMUC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3981
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883485
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88988134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1723
IRAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649977
RELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00616693
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53011
BRD-K93060291_TL_HRAS24 BRD-K93060291_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593186
PMC6279925__F4	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K26838195_AST1306_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AFF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581333
ZBED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24224
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5515
GTEX-PWN1-2026-SM-48TD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08979
BRD-K10882151_BO2 (inhibits RAD51)_LOVO_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.22599
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940398
BRD-K42392619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14329
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55951
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
COPS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18368
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837072
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
PMC4701050__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Muscle stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
hsa-miR-4419a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K24292260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73759
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51217
ICAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00352392
COL4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00876057
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839314
Thrombocytopenia	CTD Gene-Disease Associations	1.0	1.49533
BRD-K34531548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29286
WNT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00829
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TWF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50391
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MMUT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588034
PMC6964830__F8	PFOCR Pathway Figure Associations 2024	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11983
BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-TML8-1126-SM-4DXSS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853865
BRD-K60337438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30934
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_3_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051105
hsa-miR-1321	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6773
ZXDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34383
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32458
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11634954_GBR 13069 dihydrochloride_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SNU1272	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81861
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847965
BRD-K83935370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87828
BRD-K64376499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07418
TRIM69	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522564
BRD-K66884694_NCGC00167398-02_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953571
CBR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705186
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10319848-mmc1.pdf-3-HEYL_HEYL	Rummagene Transcription Factor Associations 2026	1.0	null
MEIOSIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97133
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BSPRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82643
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ES3	GDSC Cell Line Gene Expression Profiles	1.0	1.50218
hydrometra	IMPC Knockout Mouse Phenotypes	1.0	null
RTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49487
BRD-K84935903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13393
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57238
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.022
GSE233256_0_v_1_rbms1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51816706_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55027
IRS2_KO_GDS1219_304_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K43775480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28877
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81528515_nilotinib_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13294
DNAJC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58217
Interstitial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
mantle zone of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12036
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847425
KP1N	DepMap CRISPR Gene Dependency	1.0	5.77005
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01454
BRD-K44946060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19933
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_14382_KD_PAX8_SRP276625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.85707
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.66912
Chondroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.263
rostral secondary prosencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06315
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LATS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05902
IFIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15877
HSD17B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559855
NBAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625222
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04854
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61312
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27254
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K51520673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06873
FDX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590608
PPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00498433
Mesenchymal stem cell_Bone marrow_Human	CellMarker Gene-Cell Type Associations	1.0	null
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.969
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.30032
Hyperplasia	CTD Gene-Disease Associations	1.0	1.9439
PMC12631116-ijbsv21p6674s5.csv--Differential_analysis_of_RNA-Seq_data_in_HCT116-ETV4_cells_combined_with_correlation_analysis_of_LOXL2_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
mammary epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.610138
GTEX-X15G-1626-SM-3NMB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18262
GRIN3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662227
PUM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623691
PLEKHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89513
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67075780_TGX-115_MDST8_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SF3B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32694
BRD-K67868012_PI-103_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFP36L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55757
Subceruleus nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42163
SLC48A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21165
RAB23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070505
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63274
BRD-K85909950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90665
GTEX-OOBJ-3026-SM-3NB1D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901237
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
morphine_mus musculus_gpl6246_gse17731	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A79768653_sirolimus_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
Islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09353
BRD-A97701745_PINDOLOL_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BCL9L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66214
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01227
TNFRSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828346
DICER1_Deficiency_GDS3685_518_mouse_Hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CCDC181	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059043
BRD-A19195498_TRIMIPRAMINE MALEATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-1626-SM-48FF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00246
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92073
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.832348
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PXYLP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406255
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1488
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65304
Mesenchymal stromal cell_Bone marrow_Human	CellMarker Gene-Cell Type Associations	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.564
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902663
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62105
BRD-K59870481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.84718
CRCGN008_HEPG2_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0702
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16375
lateral IC periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21543
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11265
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840709
Fibroblast_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13602
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6871-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26217579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46953
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34092
BRD-K46872340_KUC103672 KUC103672N_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14914_KD_RARRES1_SRP265304	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.94622
CX-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
RNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88738
Brain Diseases	CTD Gene-Disease Associations	1.0	1.52413
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SPINK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00436913
FADU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ovary_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.876882
POMC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00776379
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65527
Perturb_16915_KD_Brf1_SRP375944	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.19523
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37933
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23425
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.2065
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
AZIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501947
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5106
BRD-K21680192_mitoxantrone_A549_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03296
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09638
LIG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0079294
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A08759443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56734
FGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02616
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10202654-mmc3.xlsx-MSC_markers-COMMON_MSC_MARKERS_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97973
ALDH9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57535
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Leucine-rich repeat, typical subtype	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K41925105_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953541
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4756-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K49635910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60969
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41082
WNT_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21632
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14246
Perturb_13428_KO_Usp28_SRP044274	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.415
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840007
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039363
BRD-K74402642_Chemistry 2804_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226249_2_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881009
BRD-K79090631_CGP-60474_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23417
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56316
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50023
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
AIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14429
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PLIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57754
BRD-K85606544_neratinib_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MAML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20531
PRDM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00446797
EHF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00375156
NME3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482005
hydrocortisone_homo sapiens_gpl570_normal scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
CER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04528
BRD-K30993697_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0253
Anemia	CTD Gene-Disease Associations	1.0	1.69254
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.056
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561178
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
15869706-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K48727830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00694
IL12RB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00735912
NTRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479915
hsa-let-7e	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP1R15A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051526
hsa-miR-3188	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4997
Interstitial lung disease 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
SAMD4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00367435
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866336
CRCGN015_HEPG2_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05797
CD79B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621254
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6667477-41467_2019_11105_MOESM8_ESM.xlsx-Fig_1d_e-HDR_fold_change_relative_to_control_Figure_1d_e_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phosphopantothenoylcysteine decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.987
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.49864
BRD-K50140147_NVP-TAE684_BT20_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Leydig precursor cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
CLEC14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26651
ECH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24605
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_4471_KO_Prdm12_SRP334439	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.23725
TBC1D7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00790339
BRD-K99220724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22192
BRD-A22089150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34412
KCNJ15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00891375
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ARPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25912
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834357
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
BRD-K12994359_Valdecoxib_CL34_6.0_h_177.6_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cardiovascular Abnormalities	CTD Gene-Disease Associations	1.0	1.29164
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31374
BLZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603247
BRD-K49075727_nintedanib_LNCAP_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K32259584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54063
CAPAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.178829
CD1E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677179
BRD-K34310783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24684
TRERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.673
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77883
vesicle	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-3972	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	2.13399
FOSL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569131
GJA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520418
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JUND	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774327
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.778
BRD-K70537701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2132
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19023
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930323
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PGRMC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441282
MYC	ENCODE Transcription Factor Targets	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29282
TC205	DepMap CRISPR Gene Dependency	1.0	2.84234
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70568
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054547
CDK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657039
GARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83865
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.984091
GTEX-WRHU-0326-SM-3MJFY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859466
PI4K2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621535
Lung squamous cell carcinoma_LUSC_TCGA-56-8625-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640732
18698033-tableS1-PLAU	GeneSigDB Published Gene Signatures	1.0	null
E2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55058
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469824
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.16533
ZNF691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42096
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K27864398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51584
ACACB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710952
GSE189336_1_v_0_nitric oxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42827
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19719
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6417
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98684
CELSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58066
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32062
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.424
DNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95115
HDAC6_KO_GSE27896_383_mouse_Foxp3+ T-regulatory cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cholestasis	CTD Gene-Disease Associations	1.0	1.44001
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06213
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99499
BRD-K81206010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2653
GSE114685_1_v_0_grin2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_chimp_DRSG_lowerRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88378636_withaferin-a_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
15958557-TableS1	GeneSigDB Published Gene Signatures	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35297
NP5	DepMap CRISPR Gene Dependency	1.0	3.24611
GSE210580_0_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUMBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33373
KIF5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583776
hsa-miR-4739	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9055
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NUDT16L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24594
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42913
para-abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16316
SPPL2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00769181
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51899
VCAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725438
Retina	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K51662849_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4259	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K17904341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1157
NFAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647934
TP53_01_68	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59715
MRPL30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55379
ACKR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618067
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35869
BRD-K92008394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69253
IST-MES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNCA_KO_GDS4153_527_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61842
GUCY2F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535162
ZNF80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0089095
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.85637
TXNDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9638
GTSF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539375
TTLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23845
Perturb_1669_KO_Rigi/Mda5_SRP119759	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.10101
NCOA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618927
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20440082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58277
DYRK1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48869
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057835
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.41585
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21896
NCIH322	CCLE Cell Line Gene CNV Profiles	1.0	2.30415
BRD-K87743988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60957
FKBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61221
OCUM-1	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25379
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52399
BRD-K56700933_PEITC_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676012
Multiple Myeloma	CTD Gene-Disease Associations	1.0	1.06625
BRD-A37837077_C247_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78659596_MLN2238_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39314
HSF1_KD_GDS1733_752_human_HeLa cells - 2 Hour by siHSF1_1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1549
Perturb_17319_KO_Dazl_SRP128645	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09137
BRD-K25737009_-666_SKMEL1_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05846874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44875
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3632
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6695
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0859
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43610632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28856
BRD-K56241426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05424
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
19605494-TableS3	GeneSigDB Published Gene Signatures	1.0	null
MDAMB453	CCLE Cell Line Gene CNV Profiles	-1.0	-2.85417
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
SLC5A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676402
HEYL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0443
ZNF512B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60523
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22911
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscular Dystrophy_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE3252	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.49909
Lung Diseases	CTD Gene-Disease Associations	1.0	1.33346
Lung adenocarcinoma_LUAD_TCGA-44-6775-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18768614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13109
BRD-K59028365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18786
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857165
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19025
BRD-K00191683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61435
Hematuria	CTD Gene-Disease Associations	1.0	1.04831
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99226
C1QTNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06698
CRABP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89782
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22024
Perturb_3001_KO_Lrp6_SRP116923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.8633
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3409
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18409585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09755
HSF1_01_155	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59347
MDST8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CACNG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00841603
GTEX-W5WG-1026-SM-4LMIF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19995
TE159T	CCLE Cell Line Gene Expression Profiles	1.0	1.85598
PSG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572068
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
substantia nigra compacta, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04704
ZMAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613939
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.45917
r2 part of the ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30927
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848427
BRD-K00910650_NCGC00242335-01_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0635
THRAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00074
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.872356
GTEX-XUJ4-1526-SM-4BONU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21344
estradiol_mus musculus_gpl81_gse1839	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32853527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28741
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69918256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61541
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.48847
LTC4S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694676
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.54257
ABI3BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00857155
CTSA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062339
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828095
Hodgkin's lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.298
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFE184	CCLE Cell Line Gene CNV Profiles	-1.0	-1.563
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20785
GSE193351_4_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79576342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71654
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842317
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05383
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.05932
PRKAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0036286
NUDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612733
PRRX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588002
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11309
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.00728
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K96799727_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_12690_KD_GRASLND_SRP192895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
KPL1	DepMap CRISPR Gene Dependency	1.0	5.1204
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8842
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.87084
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879867
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54837058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27883
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07716
ZNF544	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98491
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAB5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92439
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A21814529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28225
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052514
BRD-K20026212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.63215
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_812_OE_TRIB3_SRP262247	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.85231
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35147
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987799
BRD-K04853698_-666_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8323949-pcbi.1009228.s004.xlsx-LUM-N10_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78599730_manumycin A_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TGFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508635
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65792
MYOCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3963
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4R-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15348_KD_SMARCD3_SRP329316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.95592
KLK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60687
Perturb_4416_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.97131
ZBTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49129
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848427
BRD-K92317137_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05567
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840347
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCL4L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658027
NCKIPSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64626
KYM1	CCLE Cell Line Gene Expression Profiles	1.0	1.65178
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5133
BRD-K69093885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43149
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.989823
GSE196699_7_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98834634_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC13138062-mmc7.xlsx-DUGs_ESR1_targets-DUGs_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
USP27X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62236